{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T02:33:59Z","timestamp":1773801239913,"version":"3.50.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Cultivation grant for clinical and basic integration research of Shanghai Tenth People's Hospital","award":["SYYYRH-2025-019"],"award-info":[{"award-number":["SYYYRH-2025-019"]}]},{"name":"General Program of the National Natural Science Foundation of China","award":["82272184"],"award-info":[{"award-number":["82272184"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflamm. Res."],"DOI":"10.1007\/s00011-026-02201-0","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T11:19:40Z","timestamp":1773746380000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrative transcriptomic analysis reveals alternative splicing programs in sepsis-induced myocardial injury across dual mouse models"],"prefix":"10.1007","volume":"75","author":[{"given":"Shuqin","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongfeng","family":"Zong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Nie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songjuan","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanzhuo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinxia","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingming","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hu","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,17]]},"reference":[{"issue":"6","key":"2201_CR1","doi-asserted-by":"publisher","first-page":"1952","DOI":"10.1007\/s10753-024-02017-2","volume":"47","author":"B Abuduaini","year":"2024","unstructured":"Abuduaini B, Jiyuan Z, Rehati A, Liang Z, Yunlin S. Regulation of alternative splicing of lipid metabolism genes in sepsis-induced liver damage by RNA-binding proteins. Inflammation. 2024;47(6):1952\u201368. https:\/\/doi.org\/10.1007\/s10753-024-02017-2.","journal-title":"Inflammation"},{"issue":"9","key":"2201_CR2","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1056\/NEJMra1208623","volume":"369","author":"DC Angus","year":"2013","unstructured":"Angus DC, van der Poll T. Severe sepsis and septic shock. N Engl J Med. 2013;369(9):840\u201351. https:\/\/doi.org\/10.1056\/NEJMra1208623.","journal-title":"N Engl J Med"},{"issue":"7","key":"2201_CR3","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1038\/nrm.2017.27","volume":"18","author":"FE Baralle","year":"2017","unstructured":"Baralle FE, Giudice J. Alternative splicing as a regulator of development and tissue identity. Nat Rev Mol Cell Biol. 2017;18(7):437\u201351. https:\/\/doi.org\/10.1038\/nrm.2017.27.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"2201_CR4","doi-asserted-by":"publisher","first-page":"R6","DOI":"10.1186\/gb-2004-6-1-r6","volume":"6","author":"RB Caldwell","year":"2005","unstructured":"Caldwell RB, Kierzek AM, Arakawa H, Bezzubov Y, Zaim J, Fiedler P, Kutter S, Blagodatski A, Kostovska D, Koter M, Plachy J, Carninci P, Hayashizaki Y, Buerstedde J. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Genome Biol. 2005;6(1):R6. https:\/\/doi.org\/10.1186\/gb-2004-6-1-r6.","journal-title":"Genome Biol"},{"key":"2201_CR5","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/j.jss.2022.03.030","volume":"278","author":"HJ Chen","year":"2022","unstructured":"Chen HJ, Meng SP, Liu C, Liu FR, Ding FY, Hu YL, Cheng ZY. Silencing of long noncoding RNA MIAT contributes to relieving sepsis-induced myocardial depression via the NF-kappaB axis. J Surg Res. 2022;278:282\u201392. https:\/\/doi.org\/10.1016\/j.jss.2022.03.030.","journal-title":"J Surg Res"},{"key":"2201_CR6","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.bbrc.2023.03.002","volume":"655","author":"YZ Chen","year":"2023","unstructured":"Chen YZ, Liu D, Li XF, Nie K, Yan SJ, Peng H, Zhuang YG, Sun MM. Aggressive alternative splicing events discovered in cecum ligation and puncture induced lung injury. Biochem Biophys Res Commun. 2023;655:90\u20136. https:\/\/doi.org\/10.1016\/j.bbrc.2023.03.002.","journal-title":"Biochem Biophys Res Commun"},{"issue":"11","key":"2201_CR7","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1038\/nsmb.1912","volume":"17","author":"M Dutertre","year":"2010","unstructured":"Dutertre M, Sanchez G, De Cian M, Barbier J, Dardenne E, Gratadou L, Dujardin G, Le Jossic-Corcos C, Corcos L, Auboeuf D. Cotranscriptional exon skipping in the genotoxic stress response. Nat Struct Mol Biol. 2010;17(11):1358\u201366. https:\/\/doi.org\/10.1038\/nsmb.1912.","journal-title":"Nat Struct Mol Biol"},{"issue":"10","key":"2201_CR8","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1038\/nrg3778","volume":"15","author":"XD Fu","year":"2014","unstructured":"Fu XD, Ares MJ. Context-dependent control of alternative splicing by RNA-binding proteins. Nat Rev Genet. 2014;15(10):689\u2013701. https:\/\/doi.org\/10.1038\/nrg3778.","journal-title":"Nat Rev Genet"},{"key":"2201_CR9","doi-asserted-by":"publisher","unstructured":"Gao HQ, Xie R, Huang R, Wang CL, Wang Y, Wang DD, Liu KM, Yang CH, Yang QX, Chen L. (2022) CIRBP regulates pancreatic cancer cell ferroptosis and growth by directly binding to p53. J Immunol Res 2022;2527210. https:\/\/doi.org\/10.1155\/2022\/2527210","DOI":"10.1155\/2022\/2527210"},{"issue":"4","key":"2201_CR10","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1161\/ATVBAHA.120.315373","volume":"41","author":"Z Hu","year":"2021","unstructured":"Hu Z, Liu WD, Hua XM, Chen X, Chang Y, Hu YQ, Xu ZY, Song JP. Single-cell transcriptomic atlas of different human cardiac arteries identifies cell types associated with vascular physiology. Arterioscler Thromb Vasc Biol. 2021;41(4):1408\u201327. https:\/\/doi.org\/10.1161\/ATVBAHA.120.315373.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"3","key":"2201_CR11","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1038\/ng.3192","volume":"47","author":"MK Iyer","year":"2015","unstructured":"Iyer MK, Niknafs YS, Malik R, Singhal U, Sahu A, Hosono Y, Barrette T, Barrette T, Evans J, Zhao S, Poliakov A, Cao XH, Dhanasekaran S, Wu YM, Robinson D, Beer DG, Feng FY, Iyer HK, Chinnaiyan AM. The landscape of long noncoding RNAs in the human transcriptome. Nat Genet. 2015;47(3):199\u2013208. https:\/\/doi.org\/10.1038\/ng.3192.","journal-title":"Nat Genet"},{"issue":"6","key":"2201_CR12","doi-asserted-by":"publisher","first-page":"3437","DOI":"10.1002\/jsfa.13229","volume":"104","author":"W Jiang","year":"2024","unstructured":"Jiang W, Tan J, Zhang JC, Deng X, He XY, Zhang J, Liu LT, Sun R, Sun MX, Chen K, Xu TJ, Yan YL, Moazzami A, Wu EJ, Zhan JS, Hu, BH. Polysaccharides from dendrobium officinale improve obesity-induced insulin resistance through the gut microbiota and the SOCS3-mediated insulin receptor substrate-1 signaling pathway. J Sci Food Agric. 2024;104(6):3437\u201347. https:\/\/doi.org\/10.1002\/jsfa.13229.","journal-title":"J Sci Food Agric"},{"issue":"2","key":"2201_CR13","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1161\/CIRCGENETICS.109.904698","volume":"3","author":"SW Kong","year":"2010","unstructured":"Kong SW, Hu YW, Ho JWK, Ikeda S, Polster S, John R, Hall JL, Bisping E, Pieske B, Dos Remedios CG, Pu WT. Heart failure-associated changes in RNA splicing of sarcomere genes. Circ Cardiovasc Genet. 2010;3(2):138\u201346. https:\/\/doi.org\/10.1161\/CIRCGENETICS.109.904698.","journal-title":"Circ Cardiovasc Genet"},{"issue":"8","key":"2201_CR14","doi-asserted-by":"publisher","first-page":"168497","DOI":"10.1016\/j.jmb.2024.168497","volume":"436","author":"FFY Lee","year":"2024","unstructured":"Lee FFY, Harris C, Alper S. RNA binding proteins that mediate LPS-induced alternative splicing of the MyD88 innate immune regulator. J Mol Biol. 2024;436(8):168497. https:\/\/doi.org\/10.1016\/j.jmb.2024.168497.","journal-title":"J Mol Biol"},{"issue":"2","key":"2201_CR15","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.resinv.2024.12.016","volume":"63","author":"YL Liu","year":"2025","unstructured":"Liu YL, Zhu H, Chen H, Gao Y, Wang TY, Wang XD, Xie H. LPS-induced TMBIM6 splicing drives endothelial necroptosis and aggravates ALI. Respir Investig. 2025;63(2):191\u20139. https:\/\/doi.org\/10.1016\/j.resinv.2024.12.016.","journal-title":"Respir Investig"},{"issue":"7","key":"2201_CR16","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1161\/CIRCULATIONAHA.106.678359","volume":"116","author":"MW Merx","year":"2007","unstructured":"Merx MW, Weber C. Sepsis and the heart. Circulation. 2007;116(7):793\u2013802. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.106.678359.","journal-title":"Circulation"},{"issue":"11","key":"2201_CR17","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1016\/j.jacc.2020.01.014","volume":"75","author":"SP Murphy","year":"2020","unstructured":"Murphy SP, Kakkar R, McCarthy CP, Januzzi JLJ. Inflammation in heart failure: JACC state-of-the-art review. J Am Coll Cardiol. 2020;75(11):1324\u201340. https:\/\/doi.org\/10.1016\/j.jacc.2020.01.014.","journal-title":"J Am Coll Cardiol"},{"key":"2201_CR18","doi-asserted-by":"publisher","first-page":"113878","DOI":"10.1016\/j.intimp.2024.113878","volume":"146","author":"K Nie","year":"2025","unstructured":"Nie K, Kadier A, Jia S, Liu D, Tong N, Tuerxun M, Aisha A, Peng H, Zhuang YG, Chen YZ, Jiang JX, Sun MM, Fang Y, Chen H. Comparative study of transcriptomic alterations in sepsis-induced acute liver injury: deciphering the role of alternative splicing in mouse models. Int Immunopharmacol. 2025;146:113878. https:\/\/doi.org\/10.1016\/j.intimp.2024.113878.","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"2201_CR19","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1021\/pr400820","volume":"13","author":"CNI Pang","year":"2014","unstructured":"Pang CNI, Tay AP, Aya C, Twine NA, Harkness L, Hart-Smith G, Chia SZ, Chen ZL, Deshpande NP, Kaakoush NO, Mitchell HM, Kassem M, Wilkins MR. Tools to covisualize and coanalyze proteomic data with genomes and transcriptomes: validation of genes and alternative mRNA splicing. J Proteome Res. 2014;13(1):84\u201398. https:\/\/doi.org\/10.1021\/pr400820.","journal-title":"J Proteome Res"},{"issue":"7","key":"2201_CR20","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/j.tcm.2004.08.001","volume":"14","author":"H Prentice","year":"2004","unstructured":"Prentice H, Webster KA. Genomic and proteomic profiles of heart disease. Trends Cardiovasc Med. 2004;14(7):282\u20138. https:\/\/doi.org\/10.1016\/j.tcm.2004.08.001.","journal-title":"Trends Cardiovasc Med"},{"issue":"1","key":"2201_CR21","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/s13054-021-03481-0","volume":"25","author":"XX Qi","year":"2021","unstructured":"Qi XX, Yu Y, Sun R, Huang JM, Liu L, Yang YX, Rui T, Sun BW. Identification and characterization of neutrophil heterogeneity in sepsis. Crit Care. 2021;25(1):50. https:\/\/doi.org\/10.1186\/s13054-021-03481-0.","journal-title":"Crit Care"},{"key":"2201_CR22","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.abb.2016.05.009","volume":"603","author":"DH Ran","year":"2016","unstructured":"Ran DH, Chen LX, Xie WY, Xu Q, Han Z, Huang HP, Zhou XD. Cold-inducible RNA binding protein regulates mucin expression induced by cold temperatures in human airway epithelial cells. Arch Biochem Biophys. 2016;603:81\u201390. https:\/\/doi.org\/10.1016\/j.abb.2016.05.009.","journal-title":"Arch Biochem Biophys"},{"issue":"1","key":"2201_CR23","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/nprot.2008.214","volume":"4","author":"D Rittirsch","year":"2009","unstructured":"Rittirsch D, Huber-Lang MS, Flierl MA, Ward PA. Immunodesign of experimental sepsis by cecal ligation and puncture. Nat Protoc. 2009;4(1):31\u20136. https:\/\/doi.org\/10.1038\/nprot.2008.214.","journal-title":"Nat Protoc"},{"issue":"6","key":"2201_CR24","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.1097\/01.CCM.0000266683.64081.02","volume":"35","author":"A Rudiger","year":"2007","unstructured":"Rudiger A, Singer M. Mechanisms of sepsis-induced cardiac dysfunction. Crit Care Med. 2007;35(6):1599\u2013608. https:\/\/doi.org\/10.1097\/01.CCM.0000266683.64081.02.","journal-title":"Crit Care Med"},{"issue":"8","key":"2201_CR25","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1001\/jama.2016.0287","volume":"315","author":"M Singer","year":"2016","unstructured":"Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, Bellomo R, Bernard GR, Chiche JD, Coopersmith CM, Hotchkiss RS, Levy MM, Marshall JC, Martin GS, Opal SM, Rubenfeld GD, van der Poll T, Vincent JL, Angus DC. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016;315(8):801\u201310. https:\/\/doi.org\/10.1001\/jama.2016.0287.","journal-title":"JAMA"},{"issue":"2","key":"2201_CR26","doi-asserted-by":"publisher","first-page":"99","DOI":"10.2220\/biomedres.29.99","volume":"29","author":"T Suzuki","year":"2008","unstructured":"Suzuki T, Sato F, Kondo J, Liu Y, Kusumi T, Fujimoto K, Kato Y, Sato T, Kijima H. Period is involved in the proliferation of human pancreatic MIA-PaCa2 cancer cells by TNF-alpha. Biomed Res. 2008;29(2):99\u2013103. https:\/\/doi.org\/10.2220\/biomedres.29.99.","journal-title":"Biomed Res"},{"issue":"10","key":"2201_CR27","doi-asserted-by":"publisher","first-page":"1676","DOI":"10.1091\/mbc.E15-11-0798","volume":"27","author":"WY Tarn","year":"2016","unstructured":"Tarn WY, Kuo HC, Yu HI, Liu SW, Tseng CT, Dhananjaya D, Hung KY, Tu CC, Chang SH, Huang GJ, Chiu IM. RBM4 promotes neuronal differentiation and neurite outgrowth by modulating numb isoform expression. Mol Biol Cell. 2016;27(10):1676\u201383. https:\/\/doi.org\/10.1091\/mbc.E15-11-0798.","journal-title":"Mol Biol Cell"},{"issue":"1","key":"2201_CR28","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1038\/nbt.2450","volume":"31","author":"C Trapnell","year":"2013","unstructured":"Trapnell C, Hendrickson DG, Sauvageau M, Goff L, Rinn JL, Pachter L. Differential analysis of gene regulation at transcript resolution with RNA-seq. Nat Biotechnol. 2013;31(1):46\u201353. https:\/\/doi.org\/10.1038\/nbt.2450.","journal-title":"Nat Biotechnol"},{"issue":"6728","key":"2201_CR29","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1038\/19323","volume":"398","author":"GT van der Horst","year":"1999","unstructured":"van der Horst GT, Muijtjens M, Kobayashi K, Takano R, Kanno S, Takao M, de Wit J, Verkerk A, Eker AP, van Leenen D, Buijs R, Bootsma D, Hoeijmakers JH, Yasui A. Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms. Nature. 1999;398(6728):627\u201330. https:\/\/doi.org\/10.1038\/19323.","journal-title":"Nature"},{"issue":"7221","key":"2201_CR30","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1038\/nature07509","volume":"456","author":"ET Wang","year":"2008","unstructured":"Wang ET, Sandberg R, Luo SJ, Khrebtukova I, Zhang L, Mayr C, Kingsmore SF, Schroth GP, Burge CB. Alternative isoform regulation in human tissue transcriptomes. Nature. 2008;456(7221):470\u20136. https:\/\/doi.org\/10.1038\/nature07509.","journal-title":"Nature"},{"issue":"1","key":"2201_CR31","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1203\/PDR.0b013e3181c13326","volume":"67","author":"S Wellmann","year":"2010","unstructured":"Wellmann S, Truss M, Bruder E, Tornillo L, Zelmer A, Seeger K, Buhrer C. The RNA-binding protein RBM3 is required for cell proliferation and protects against serum deprivation-induced cell death. Pediatr Res. 2010;67(1):35\u201341. https:\/\/doi.org\/10.1203\/PDR.0b013e3181c13326.","journal-title":"Pediatr Res"},{"issue":"2","key":"2201_CR32","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1080\/10425170400020373","volume":"16","author":"MQ Wu","year":"2005","unstructured":"Wu MQ, Gu SH, Xu J, Zou XQ, Zheng HR, Jin Z, Xie Y, Ji CN, Mao YM. A novel splice variant of human gene NPL, mainly expressed in human liver, kidney and peripheral blood leukocyte. DNA Seq. 2005;16(2):137\u201342. https:\/\/doi.org\/10.1080\/10425170400020373.","journal-title":"DNA Seq"},{"issue":"1","key":"2201_CR33","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1038\/s41420-021-00563-4","volume":"7","author":"SJ Wu","year":"2021","unstructured":"Wu SJ, Zhang Y, You SL, Lu S, Zhang NJ, Sun YX. Septin4 promotes cardiomyocytes apoptosis by enhancing the VHL-mediated degradation of HIF-1alpha. Cell Death Discov. 2021;7(1):172. https:\/\/doi.org\/10.1038\/s41420-021-00563-4.","journal-title":"Cell Death Discov"},{"key":"2201_CR34","doi-asserted-by":"publisher","first-page":"7682","DOI":"10.12659\/MSM.909909","volume":"24","author":"ZH Xiao","year":"2018","unstructured":"Xiao ZH, Jia BS, Zhao XS, Bi SW, Meng W. Attenuation of lipopolysaccharide-induced acute lung injury by cyclosporine-A via suppression of mitochondrial DNA. Med Sci Monit. 2018;24:7682\u20138. https:\/\/doi.org\/10.12659\/MSM.909909.","journal-title":"Med Sci Monit"},{"key":"2201_CR35","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1016\/j.omtn.2019.07.020","volume":"17","author":"TN Zhang","year":"2019","unstructured":"Zhang TN, Goodwin JE, Liu B, Li D, Wen R, Yang N, Xia J, Zhou H, Zhang T, Song WL, Liu CF. Characterization of long noncoding RNA and mRNA profiles in sepsis-induced myocardial depression. Mol Ther Nucleic Acids. 2019;17:852\u201366. https:\/\/doi.org\/10.1016\/j.omtn.2019.07.020.","journal-title":"Mol Ther Nucleic Acids"},{"key":"2201_CR36","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1681\/asn.20223311s1360b","volume":"33","author":"A Zollman","year":"2022","unstructured":"Zollman A, Halim A, Myslinski J, Dagher PC, Hato T. Transcript isoform switching in sepsis-induced AKI. J Am Soc Nephrol. 2022;33:360. https:\/\/doi.org\/10.1681\/asn.20223311s1360b.","journal-title":"J Am Soc Nephrol"}],"container-title":["Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00011-026-02201-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00011-026-02201-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00011-026-02201-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T23:02:34Z","timestamp":1773788554000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00011-026-02201-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,17]]},"references-count":36,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2201"],"URL":"https:\/\/doi.org\/10.1007\/s00011-026-02201-0","relation":{},"ISSN":["1420-908X"],"issn-type":[{"value":"1420-908X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,17]]},"assertion":[{"value":"18 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 January 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 March 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"50"}}