{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T14:12:16Z","timestamp":1785247936316,"version":"3.55.0"},"reference-count":109,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflamm. Res."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sepsis and septic shock are major causes of mortality in critically ill patients. They are linked to widespread metabolic and immune dysregulation, including alterations in calcium and phosphate homeostasis. The calcium-sensing receptor (CaSR) not only plays a role in mineral balance, but also modulates key immune pathways and may contribute to the pathogenesis of sepsis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic literature review was conducted according to PRISMA 2020 guidelines. Four databases (PubMed, EMBASE, Cochrane Library, and Google Scholar) were searched for studies published since 1990. To be eligible for inclusion, articles had to be original research, reviews, or clinical trials involving adult models (mammalian or human). Full-text availability was required. Risk of bias was assessed for all studies included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixty-six articles met the inclusion criteria: 49 original studies and 17 reviews. No randomized controlled trials or meta-analyses were identified. Most studies relied on in vitro or in vivo models. CaSR was consistently reported to be upregulated or activated following exposure to bacterial and inflammatory stimuli in immune cells, including monocytes and lymphocytes. CaSR activation promotes proinflammatory cytokine release, notably IL-1\u03b2 via the NOD like receptor family 3 (NLRP3) inflammasome although results in intestinal epithelial models remain inconsistent. In non-septic models, CaSR activation was associated with tissue and organ injury, including renal and cardiac damage, as well as vasoplegia related to endothelial dysfunction. Preclinical models of pneumonia and endotoxemia suggest that CaSR antagonists may effectively mitigate inflammation and organ injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This systematic review identifies the CaSR as an amplifier of the host inflammatory response across both septic and non-septic preclinical models The lack of robust clinical data underscores the need for translational studies assessing CaSR expression or activity in patients with sepsis or septic shock, alongside in vivo validation of CaSR inhibition as a therapeutic strategy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00011-026-02227-4","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T20:02:15Z","timestamp":1776456135000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The calcium-sensing receptor in sepsis and septic shock, mechanistic pathways and translational perspectives: a systematic review"],"prefix":"10.1007","volume":"75","author":[{"given":"Valentine","family":"Janssen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sa\u00efd","family":"Kamel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Slama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osama","family":"Abou-Arab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Brazier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romuald","family":"Mentaverri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lien","family":"Mary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,17]]},"reference":[{"key":"2227_CR1","unstructured":"WHO calls for global action on sepsis - cause. of 1 in 5 deaths worldwide [Internet]. [cited 2025 Jan 2]. https:\/\/www.who.int\/news\/item\/08-09-2020-who-calls-for-global-action-on-sepsis---cause-of-1-in-5-deaths-worldwide. Accessed 2 Jan 2025."},{"key":"2227_CR2","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1007\/s00134-021-06506-y","volume":"47","author":"L Evans","year":"2021","unstructured":"Evans L, Rhodes A, Alhazzani W, Antonelli M, Coopersmith CM, French C, et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Intensive Care Med. 2021;47:1181\u2013247. https:\/\/doi.org\/10.1007\/s00134-021-06506-y.","journal-title":"Intensive Care Med"},{"key":"2227_CR3","doi-asserted-by":"publisher","first-page":"e1071","DOI":"10.1097\/CCE.0000000000001071","volume":"6","author":"D Chaudhuri","year":"2024","unstructured":"Chaudhuri D, Israelian L, Putowski Z, Prakash J, Pitre T, Nei AM, et al. Adverse effects related to corticosteroid use in sepsis, acute respiratory distress syndrome, and community-acquired pneumonia: a systematic review and meta-analysis. Crit Care Explor. 2024;6:e1071. https:\/\/doi.org\/10.1097\/CCE.0000000000001071.","journal-title":"Crit Care Explor"},{"key":"2227_CR4","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1177\/1060028018812940","volume":"53","author":"JM Allen","year":"2019","unstructured":"Allen JM, Feild C, Shoulders BR, Voils SA. Recent updates in the pharmacological management of sepsis and septic shock: a systematic review focused on fluid resuscitation, vasopressors, and corticosteroids. Ann Pharmacother. 2019;53:385\u201395. https:\/\/doi.org\/10.1177\/1060028018812940.","journal-title":"Ann Pharmacother"},{"key":"2227_CR5","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1186\/s13054-024-04964-6","volume":"28","author":"MA Slim","year":"2024","unstructured":"Slim MA, van Mourik N, Bakkerus L, Fuller K, Acharya L, Giannidis T, et al. Towards personalized medicine: a scoping review of immunotherapy in sepsis. Crit Care. 2024;28:183. https:\/\/doi.org\/10.1186\/s13054-024-04964-6.","journal-title":"Crit Care"},{"key":"2227_CR6","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1001\/archsurg.1992.01420030027005","volume":"127","author":"KW Burchard","year":"1992","unstructured":"Burchard KW, Simms HH, Robinson A, DiAmico R, Gann DS. Hypocalcemia during sepsis. Relationship to resuscitation and hemodynamics. Arch Surg. 1992;127:265\u201372. https:\/\/doi.org\/10.1001\/archsurg.1992.01420030027005.","journal-title":"Arch Surg"},{"key":"2227_CR7","doi-asserted-by":"publisher","first-page":"R106","DOI":"10.1186\/cc12756","volume":"17","author":"T Steele","year":"2013","unstructured":"Steele T, Kolamunnage-Dona R, Downey C, Toh C-H, Welters I. Assessment and clinical course of hypocalcemia in critical illness. Crit Care. 2013;17:R106. https:\/\/doi.org\/10.1186\/cc12756.","journal-title":"Crit Care"},{"key":"2227_CR8","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1177\/0310057X1704500106","volume":"45","author":"T Greulich","year":"2017","unstructured":"Greulich T, Regner W, Branscheidt M, Herr C, Koczulla AR, Vogelmeier CF, et al Altered blood levels of vitamin D, cathelicidin and parathyroid hormone in patients with sepsis\u2014a pilot study. Anaesth Intensive Care. 2017;45:36\u201345. . https:\/\/doi.org\/10.1177\/0310057X1704500106.","journal-title":"Anaesth Intensive Care"},{"key":"2227_CR9","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/s41574-018-0115-0","volume":"15","author":"FM Hannan","year":"2018","unstructured":"Hannan FM, Kallay E, Chang W, Brandi ML, Thakker RV. The calcium-sensing receptor in physiology and in calcitropic and noncalcitropic diseases. Nat Rev Endocrinol. 2018;15:33\u201351. https:\/\/doi.org\/10.1038\/s41574-018-0115-0.","journal-title":"Nat Rev Endocrinol"},{"key":"2227_CR10","doi-asserted-by":"publisher","first-page":"257","DOI":"10.15212\/CVIA.2021.0009","volume":"5","author":"W Liu","year":"2021","unstructured":"Liu W, Guo Y, Liu YM, Sun J, Yin X. Calcium-sensing receptor of immune cells and diseases. Cardiovascular innovations and applications. Compuscript. 2021;5:257. https:\/\/doi.org\/10.15212\/CVIA.2021.0009.","journal-title":"Compuscript"},{"key":"2227_CR11","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1038\/nature11588","volume":"492","author":"G-S Lee","year":"2012","unstructured":"Lee G-S, Subramanian N, Kim AI, Aksentijevich I, Goldbach-Mansky R, Sacks DB, et al. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2\u2009+\u2009and cAMP. Nature. 2012;492:123\u20137. https:\/\/doi.org\/10.1038\/nature11588.","journal-title":"Nature"},{"key":"2227_CR12","doi-asserted-by":"publisher","first-page":"11284","DOI":"10.1038\/ncomms11284","volume":"7","author":"J Canton","year":"2016","unstructured":"Canton J, Schlam D, Breuer C, G\u00fctschow M, Glogauer M, Grinstein S. Calcium-sensing receptors signal constitutive macropinocytosis and facilitate the uptake of NOD2 ligands in macrophages. Nat Commun Nat Publishing Group. 2016;7:11284. https:\/\/doi.org\/10.1038\/ncomms11284.","journal-title":"Nat Commun Nat Publishing Group"},{"key":"2227_CR13","doi-asserted-by":"publisher","unstructured":"Werner LE, Wagner U. Calcium-sensing receptor-mediated NLRP3 inflammasome activation in rheumatoid arthritis and autoinflammation. Frontiers in Physiology [Internet]. 2023 [cited 2023 Nov 14];13. https:\/\/www.frontiersin.org\/articles\/https:\/\/doi.org\/10.3389\/fphys.2022.1078569. Accessed 14 Nov 2023.","DOI":"10.3389\/fphys.2022.1078569"},{"key":"2227_CR14","unstructured":"Malecki R, Fiodorenko-Dumas Z, Jakobsche-Policht U, Malodobra M, Adamiec R. ALTERED MONOCYTE CALCIUM-SENSING RECEPTOR EXPRESSION IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AND ATHEROSCLEROSIS."},{"key":"2227_CR15","unstructured":"PRISMA statement [Internet]. PRISMA statement. [cited 2025 Nov 6]. https:\/\/www.prisma-statement.org. Accessed 6 Nov 2025."},{"key":"2227_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0197-2456(95)00134-4","volume":"17","author":"AR Jadad","year":"1996","unstructured":"Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJM, Gavaghan DJ, et al. Assessing the quality of reports of randomized clinical trials: Is blinding necessary? Control Clin Trials. 1996;17:1\u201312. https:\/\/doi.org\/10.1016\/0197-2456(95)00134-4.","journal-title":"Control Clin Trials"},{"key":"2227_CR17","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/1471-2288-7-10","volume":"7","author":"BJ Shea","year":"2007","unstructured":"Shea BJ, Grimshaw JM, Wells GA, Boers M, Andersson N, Hamel C, et al. Development of AMSTAR: a measurement tool to assess the methodological quality of systematic reviews. BMC Med Res Methodol. 2007;7:10. https:\/\/doi.org\/10.1186\/1471-2288-7-10.","journal-title":"BMC Med Res Methodol"},{"key":"2227_CR18","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1038\/ncomms2339","volume":"3","author":"M Rossol","year":"2012","unstructured":"Rossol M, Pierer M, Raulien N, Quandt D, Meusch U, Rothe K, et al. Extracellular Ca2\u2009+\u2009is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors. Nat Commun Nat Publishing Group. 2012;3:1329. https:\/\/doi.org\/10.1038\/ncomms2339.","journal-title":"Nat Commun Nat Publishing Group"},{"key":"2227_CR19","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.molimm.2012.09.010","volume":"53","author":"T Li","year":"2013","unstructured":"Li T, Sun M, Yin X, Wu C, Wu Q, Feng S, et al. Expression of the calcium sensing receptor in human peripheral blood T lymphocyte and its contribution to cytokine secretion through MAPKs or NF-\u03baB pathways. Mol Immunol. 2013;53:414\u201320. https:\/\/doi.org\/10.1016\/j.molimm.2012.09.010.","journal-title":"Mol Immunol"},{"key":"2227_CR20","doi-asserted-by":"publisher","first-page":"4253","DOI":"10.1007\/s11033-014-3296-1","volume":"41","author":"K Zhang","year":"2014","unstructured":"Zhang K, Wang P, Huang S, Wang X, Li T, Jin Y, et al. Different mechanism of LPS-induced calcium increase in human lung epithelial cell and microvascular endothelial cell: a cell culture study in a model for ARDS. Mol Biol Rep. 2014;41:4253\u20139. https:\/\/doi.org\/10.1007\/s11033-014-3296-1.","journal-title":"Mol Biol Rep"},{"key":"2227_CR21","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.molimm.2014.10.018","volume":"64","author":"Q Wu","year":"2015","unstructured":"Wu Q, Sun M, Wu C, Li Y, Du J, Zeng J, et al. Activation of calcium-sensing receptor increases TRPC3\/6 expression in T lymphocyte in sepsis. Mol Immunol. 2015;64:18\u201325. https:\/\/doi.org\/10.1016\/j.molimm.2014.10.018.","journal-title":"Mol Immunol"},{"key":"2227_CR22","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.molimm.2014.08.007","volume":"63","author":"C Wu","year":"2015","unstructured":"Wu C, Wu Q, Du J, Zeng J, Li T, Xu C, et al. Calcium-sensing receptor in the T lymphocyte enhanced the apoptosis and cytokine secretion in sepsis. Mol Immunol. 2015;63:337\u201342. https:\/\/doi.org\/10.1016\/j.molimm.2014.08.007.","journal-title":"Mol Immunol"},{"key":"2227_CR23","doi-asserted-by":"publisher","first-page":"5953","DOI":"10.1021\/acs.jafc.7b02109","volume":"65","author":"ME Chee","year":"2017","unstructured":"Chee ME, Majumder K, Mine Y. Intervention of dietary dipeptide gamma-l-Glutamyl-l-Valine (\u03b3-EV) ameliorates inflammatory response in a mouse model of LPS-induced sepsis. J Agric Food Chem. 2017;65:5953\u201360. https:\/\/doi.org\/10.1021\/acs.jafc.7b02109.","journal-title":"J Agric Food Chem"},{"key":"2227_CR24","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.molimm.2017.07.012","volume":"90","author":"J-W Lee","year":"2017","unstructured":"Lee J-W, Park HA, Kwon O-K, Park J-W, Lee G, Lee HJ, et al. NPS 2143, a selective calcium-sensing receptor antagonist inhibits lipopolysaccharide-induced pulmonary inflammation. Mol Immunol. 2017;90:150\u20137. https:\/\/doi.org\/10.1016\/j.molimm.2017.07.012.","journal-title":"Mol Immunol"},{"key":"2227_CR25","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.4049\/jimmunol.1701212","volume":"200","author":"Z Li","year":"2018","unstructured":"Li Z, Zeppa JJ, Hancock MA, McCormick JK, Doherty TM, Hendy GN, et al. Staphylococcal Superantigens Use LAMA2 as a Coreceptor To Activate T Cells. J Immunol. 2018;200:1471\u20139. https:\/\/doi.org\/10.4049\/jimmunol.1701212.","journal-title":"J Immunol"},{"key":"2227_CR26","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1091\/mbc.E17-06-0419","volume":"29","author":"DS Redka","year":"2018","unstructured":"Redka DS, G\u00fctschow M, Grinstein S, Canton J. Differential ability of proinflammatory and anti-inflammatory macrophages to perform macropinocytosis. MBoC Am Soc Cell Biology (mboc). 2018;29:53\u201365. . https:\/\/doi.org\/10.1091\/mbc.E17-06-0419","journal-title":"MBoC Am Soc Cell Biology (mboc)"},{"key":"2227_CR27","doi-asserted-by":"publisher","first-page":"570872","DOI":"10.3389\/fimmu.2020.570872","volume":"11","author":"Y Su","year":"2020","unstructured":"Su Y, Zhang Y, Hu Z, He L, Wang W, Xu J, et al. Prokineticin 2 via calcium-sensing receptor activated NLRP3 inflammasome pathway in the testicular macrophages of uropathogenic escherichia coli-induced orchitis. Front Immunol. 2020;11:570872. https:\/\/doi.org\/10.3389\/fimmu.2020.570872.","journal-title":"Front Immunol"},{"key":"2227_CR28","doi-asserted-by":"publisher","first-page":"748497","DOI":"10.3389\/fimmu.2021.748497","volume":"12","author":"G Liu","year":"2021","unstructured":"Liu G, Gu K, Wang F, Jia G, Zhao H, Chen X, et al. Tryptophan ameliorates barrier integrity and alleviates the inflammatory response to enterotoxigenic Escherichia coli K88 through the CaSR\/Rac1\/PLC-\u03b31 signaling pathway in porcine intestinal epithelial cells. Front Immunol. 2021;12:748497. https:\/\/doi.org\/10.3389\/fimmu.2021.748497.","journal-title":"Front Immunol"},{"key":"2227_CR29","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1006\/bbrc.1997.7207","volume":"238","author":"PK Nielsen","year":"1997","unstructured":"Nielsen PK, Rasmussen \u00c5K, Butters R, Feldt-Rasmussen U, Bendtzen K, Diaz R, et al. Inhibition of PTH secretion by interleukin-1\u03b2 in bovine parathyroid Glandsin VitroIs associated with an up-regulation of the calcium-sensing receptor mRNA. Biochem Biophys Res Commun. 1997;238:880\u20135. https:\/\/doi.org\/10.1006\/bbrc.1997.7207.","journal-title":"Biochem Biophys Res Commun"},{"key":"2227_CR30","doi-asserted-by":"publisher","first-page":"F963","DOI":"10.1152\/ajprenal.00108.2002","volume":"283","author":"D Wang","year":"2002","unstructured":"Wang D, Pedraza PL, Abdullah HI, McGiff JC, Ferreri NR. Calcium-sensing receptor-mediated TNF production in medullary thick ascending limb cells. Am J Physiology-Renal Physiol Am Physiological Soc. 2002;283:F963\u201370. https:\/\/doi.org\/10.1152\/ajprenal.00108.2002.","journal-title":"Am J Physiology-Renal Physiol Am Physiological Soc"},{"key":"2227_CR31","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1677\/jme.0.0310609","volume":"31","author":"RE Toribio","year":"2003","unstructured":"Toribio RE, Kohn CW, Capen CC, Rosol TJ. Parathyroid hormone (PTH) secretion, PTH mRNA and calcium-sensing receptor mRNA expression in equine parathyroid cells, and effects of interleukin (IL)-1, IL-6, and tumor necrosis factor-alpha on equine parathyroid cell function. J Mol Endocrinol BioScientifica. 2003;31:609\u201320. https:\/\/doi.org\/10.1677\/jme.0.0310609.","journal-title":"J Mol Endocrinol BioScientifica"},{"key":"2227_CR32","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1002\/jcb.20511","volume":"96","author":"I Dal Pra","year":"2005","unstructured":"Dal Pra I, Chiarini A, Nemeth EF, Armato U, Whitfield JF. Roles of Ca2\u2009+\u2009and the Ca2+-sensing receptor (CASR) in the expression of inducible NOS (nitric oxide synthase)-2 and its BH4 (tetrahydrobiopterin)-dependent activation in cytokine-stimulated adult human astrocytes. J Cell Biochem. 2005;96:428\u201338. https:\/\/doi.org\/10.1002\/jcb.20511.","journal-title":"J Cell Biochem"},{"key":"2227_CR33","doi-asserted-by":"publisher","first-page":"14177","DOI":"10.1074\/jbc.M408587200","volume":"280","author":"L Canaff","year":"2005","unstructured":"Canaff L, Hendy GN. Calcium-sensing receptor gene transcription is up-regulated by the proinflammatory cytokine, interleukin-1\u03b2: ROLE OF THE NF-\u03baB PATHWAY AND \u03baB ELEMENTS*. J Biol Chem. 2005;280:14177\u201388. https:\/\/doi.org\/10.1074\/jbc.M408587200.","journal-title":"J Biol Chem"},{"key":"2227_CR34","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1161\/01.RES.0000178787.59594.a0","volume":"97","author":"AH Weston","year":"2005","unstructured":"Weston AH, Absi M, Ward DT, Ohanian J, Dodd RH, Dauban P, et al. Evidence in favor of a calcium-sensing receptor in arterial endothelial cells: studies with calindol and Calhex 231. Circ Res. 2005;97:391\u20138. https:\/\/doi.org\/10.1161\/01.RES.0000178787.59594.a0.","journal-title":"Circ Res"},{"key":"2227_CR35","doi-asserted-by":"publisher","first-page":"F1110","DOI":"10.1152\/ajprenal.00223.2005","volume":"290","author":"HI Abdullah","year":"2006","unstructured":"Abdullah HI, Pedraza PL, Hao S, Rodland KD, McGiff JC, Ferreri NR. NFAT regulates calcium-sensing receptor-mediated TNF production. Am J Physiology-Renal Physiol Am Physiological Soc. 2006;290:F1110\u20137. https:\/\/doi.org\/10.1152\/ajprenal.00223.2005.","journal-title":"Am J Physiology-Renal Physiol Am Physiological Soc"},{"key":"2227_CR36","doi-asserted-by":"publisher","first-page":"F1082","DOI":"10.1152\/ajprenal.90316.2008","volume":"295","author":"HI Abdullah","year":"2008","unstructured":"Abdullah HI, Pedraza PL, McGiff JC, Ferreri NR. Calcium-sensing receptor signaling pathways in medullary thick ascending limb cells mediate COX-2-derived PGE2 production: functional significance. Am J Physiology-Renal Physiol Am Physiological Soc. 2008;295:F1082\u20139. https:\/\/doi.org\/10.1152\/ajprenal.90316.2008.","journal-title":"Am J Physiology-Renal Physiol Am Physiological Soc"},{"key":"2227_CR37","doi-asserted-by":"publisher","first-page":"13586","DOI":"10.1074\/jbc.M708087200","volume":"283","author":"L Canaff","year":"2008","unstructured":"Canaff L, Zhou X, Hendy GN. The proinflammatory cytokine, interleukin-6, up-regulates calcium-sensing receptor gene transcription via Stat1\/3 and Sp1\/3. J Biol Chem. 2008;283:13586\u2013600. https:\/\/doi.org\/10.1074\/jbc.M708087200.","journal-title":"J Biol Chem"},{"key":"2227_CR38","doi-asserted-by":"publisher","first-page":"F345","DOI":"10.1152\/ajprenal.00509.2006","volume":"294","author":"HI Abdullah","year":"2008","unstructured":"Abdullah HI, Pedraza PL, McGiff JC, Ferreri NR. CaR activation increases TNF production by mTAL cells via a Gi-dependent mechanism. Am J Physiol Ren Physiol. 2008;294:F345\u2013354. https:\/\/doi.org\/10.1152\/ajprenal.00509.2006.","journal-title":"Am J Physiol Ren Physiol"},{"key":"2227_CR39","doi-asserted-by":"publisher","first-page":"F1494","DOI":"10.1152\/ajprenal.90436.2008","volume":"296","author":"S Hao","year":"2009","unstructured":"Hao S, Zhao H, Darzynkiewicz Z, Battula S, Ferreri NR. Expression and function of NFAT5 in medullary thick ascending limb (mTAL) cells. Am J Physiology-Renal Physiol Am Physiological Soc. 2009;296:F1494\u2013503. https:\/\/doi.org\/10.1152\/ajprenal.90436.2008.","journal-title":"Am J Physiology-Renal Physiol Am Physiological Soc"},{"key":"2227_CR40","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1007\/s11010-010-0489-3","volume":"342","author":"Y Xi","year":"2010","unstructured":"Xi Y, Li H, Zhang W, Wang L, Zhang L, Lin Y, et al. The functional expression of calcium-sensing receptor in the differentiated THP-1 cells. Mol Cell Biochem. 2010;342:233\u201340. https:\/\/doi.org\/10.1007\/s11010-010-0489-3.","journal-title":"Mol Cell Biochem"},{"key":"2227_CR41","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1161\/CIRCRESAHA.112.266361","volume":"111","author":"A Yamamura","year":"2012","unstructured":"Yamamura A, Guo Q, Yamamura H, Zimnicka AM, Pohl NM, Smith KA, et al. Enhanced Ca2+-sensing receptor function in idiopathic pulmonary arterial hypertension. Circulation Res Am Heart Association. 2012;111:469\u201381. https:\/\/doi.org\/10.1161\/CIRCRESAHA.112.266361.","journal-title":"Circulation Res Am Heart Association"},{"key":"2227_CR42","doi-asserted-by":"publisher","first-page":"e74800","DOI":"10.1371\/journal.pone.0074800","volume":"8","author":"J Paccou","year":"2013","unstructured":"Paccou J, Boudot C, Mary A, Kamel S, Dr\u00fceke TB, Fardellone P, et al. Determination and modulation of total and surface calcium-sensing receptor expression in monocytes in vivo and in vitro. PLoS ONE. 2013;8:e74800. https:\/\/doi.org\/10.1371\/journal.pone.0074800.","journal-title":"PLoS ONE"},{"key":"2227_CR43","doi-asserted-by":"publisher","first-page":"4158","DOI":"10.1016\/j.febslet.2014.05.007","volume":"588","author":"SX Cheng","year":"2014","unstructured":"Cheng SX, Lightfoot YL, Yang T, Zadeh M, Tang L, Sahay B, et al. Epithelial CaSR deficiency alters intestinal integrity and promotes proinflammatory immune responses. FEBS Lett. 2014;588:4158\u201366. https:\/\/doi.org\/10.1016\/j.febslet.2014.05.007.","journal-title":"FEBS Lett"},{"key":"2227_CR44","doi-asserted-by":"publisher","first-page":"284ra60","DOI":"10.1126\/scitranslmed.aaa0282","volume":"7","author":"PL Yarova","year":"2015","unstructured":"Yarova PL, Stewart AL, Sathish V, Britt RD, Thompson MA, Lowe APP, et al. Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma. Sci Transl Med. 2015;7:284ra60. https:\/\/doi.org\/10.1126\/scitranslmed.aaa0282.","journal-title":"Sci Transl Med"},{"key":"2227_CR45","doi-asserted-by":"publisher","first-page":"16719","DOI":"10.1038\/srep16719","volume":"5","author":"D Quandt","year":"2015","unstructured":"Quandt D, Rothe K, Baerwald C, Rossol M. GPRC6A mediates Alum-induced Nlrp3 inflammasome activation but limits Th2 type antibody responses. Sci Rep Nat Publishing Group. 2015;5:16719. https:\/\/doi.org\/10.1038\/srep16719.","journal-title":"Sci Rep Nat Publishing Group"},{"key":"2227_CR46","doi-asserted-by":"publisher","first-page":"10437","DOI":"10.1021\/acs.jafc.5b03812","volume":"63","author":"Y Mine","year":"2015","unstructured":"Mine Y, Zhang H. Anti-inflammatory effects of poly-L-lysine in intestinal mucosal system mediated by calcium-sensing receptor activation. J Agric Food Chem. 2015;63:10437\u201347. https:\/\/doi.org\/10.1021\/acs.jafc.5b03812.","journal-title":"J Agric Food Chem"},{"key":"2227_CR47","doi-asserted-by":"publisher","first-page":"2483","DOI":"10.1159\/000374048","volume":"35","author":"W Liu","year":"2015","unstructured":"Liu W, Zhang X, Zhao M, Zhang X, Chi J, Liu Y, et al. Activation in M1 but not M2 macrophages contributes to cardiac remodeling after myocardial infarction in rats: a critical role of the calcium sensing receptor\/NRLP3 inflammasome. Cell Physiol Biochem. 2015;35:2483\u2013500. https:\/\/doi.org\/10.1159\/000374048.","journal-title":"Cell Physiol Biochem"},{"key":"2227_CR48","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1016\/j.bbadis.2014.12.023","volume":"1852","author":"H Zhang","year":"2015","unstructured":"Zhang H, Kovacs-Nolan J, Kodera T, Eto Y, Mine Y. \u03b3-Glutamyl cysteine and \u03b3-glutamyl valine inhibit TNF-\u03b1 signaling in intestinal epithelial cells and reduce inflammation in a mouse model of colitis via allosteric activation of the calcium-sensing receptor. Biochim Biophys Acta. 2015;1852:792\u2013804. https:\/\/doi.org\/10.1016\/j.bbadis.2014.12.023.","journal-title":"Biochim Biophys Acta"},{"key":"2227_CR49","doi-asserted-by":"publisher","first-page":"3458","DOI":"10.3390\/ijms19113458","volume":"19","author":"H Rammal","year":"2018","unstructured":"Rammal H, Bour C, Dubus M, Entz L, Aubert L, Gangloff SC, et al. Combining calcium phosphates with polysaccharides: a bone-inspired material modulating monocyte\/macrophage early inflammatory response. Int J Mol Sci. 2018;19:3458. https:\/\/doi.org\/10.3390\/ijms19113458.","journal-title":"Int J Mol Sci"},{"key":"2227_CR50","doi-asserted-by":"publisher","first-page":"3585","DOI":"10.1016\/j.bbadis.2018.08.020","volume":"1864","author":"P Mattar","year":"2018","unstructured":"Mattar P, Bravo-Sagua R, Tobar N, Fuentes C, Troncoso R, Breitwieser G, et al. Autophagy mediates calcium-sensing receptor-induced TNF\u03b1 production in human preadipocytes. Biochim et Biophys Acta (BBA) - Mol Basis Disease. 2018;1864:3585\u201394. https:\/\/doi.org\/10.1016\/j.bbadis.2018.08.020.","journal-title":"Biochim et Biophys Acta (BBA) - Mol Basis Disease"},{"key":"2227_CR51","doi-asserted-by":"publisher","first-page":"6232","DOI":"10.1002\/jcp.26490","volume":"233","author":"A D\u2019Espessailles","year":"2018","unstructured":"D\u2019Espessailles A, Mora YA, Fuentes C, Cifuentes M. Calcium-sensing receptor activates the NLRP3 inflammasome in LS14 preadipocytes mediated by ERK1\/2 signaling. J Cell Physiol. 2018;233:6232\u201340. https:\/\/doi.org\/10.1002\/jcp.26490.","journal-title":"J Cell Physiol"},{"key":"2227_CR52","doi-asserted-by":"publisher","first-page":"3437","DOI":"10.3892\/ijmm.2018.3924","volume":"42","author":"J Zeng","year":"2018","unstructured":"Zeng J, Pan Y, Cui B, Zhai T, Gao S, Zhao Q, et al. Calcium\u2013sensing receptors in human peripheral T lymphocytes and AMI: cause and effect. Int J Mol Med Spandidos Publications. 2018;42:3437\u201346. https:\/\/doi.org\/10.3892\/ijmm.2018.3924.","journal-title":"Int J Mol Med Spandidos Publications"},{"key":"2227_CR53","doi-asserted-by":"publisher","first-page":"e8945850","DOI":"10.1155\/2018\/8945850","volume":"2018","author":"L Song","year":"2018","unstructured":"Song L, Gao L-N, Wang J, Thapa S, Li Y, Zhong X-B, et al. Stromal cell-derived factor-1\u03b1 alleviates calcium-sensing receptor activation-mediated ischemia\/reperfusion injury by inhibiting caspase-3\/caspase-9-induced cell apoptosis in rat free flaps. BioMed Res Int Hindawi. 2018;2018:e8945850. https:\/\/doi.org\/10.1155\/2018\/8945850.","journal-title":"BioMed Res Int Hindawi"},{"key":"2227_CR54","doi-asserted-by":"publisher","first-page":"3072","DOI":"10.3390\/nu11123072","volume":"11","author":"T Elajnaf","year":"2019","unstructured":"Elajnaf T, Iamartino L, Mesteri I, M\u00fcller C, Bassetto M, Manhardt T, et al. Nutritional and pharmacological targeting of the calcium-sensing receptor influences chemically induced colitis in mice. Nutr Multidiscip Digit Pub Inst. 2019;11:3072. https:\/\/doi.org\/10.3390\/nu11123072.","journal-title":"Nutrients Multidisciplinary Digit Publishing Inst"},{"key":"2227_CR55","doi-asserted-by":"publisher","first-page":"H59","DOI":"10.1152\/ajpheart.00308.2019","volume":"318","author":"W Zhang","year":"2020","unstructured":"Zhang W, Zhu T, Chen L, Luo W, Chao J. MCP-1 mediates ischemia-reperfusion-induced cardiomyocyte apoptosis via MCPIP1 and CaSR. Am J Physiol Heart Circ Physiol. 2020;318:H59\u201371. https:\/\/doi.org\/10.1152\/ajpheart.00308.2019.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2227_CR56","doi-asserted-by":"publisher","first-page":"4243","DOI":"10.1038\/s41467-020-17749-6","volume":"11","author":"E J\u00e4ger","year":"2020","unstructured":"J\u00e4ger E, Murthy S, Schmidt C, Hahn M, Strobel S, Peters A, et al. Calcium-sensing receptor-mediated NLRP3 inflammasome response to calciprotein particles drives inflammation in rheumatoid arthritis. Nat Commun Nat Publishing Group. 2020;11:4243. https:\/\/doi.org\/10.1038\/s41467-020-17749-6.","journal-title":"Nat Commun Nat Publishing Group"},{"key":"2227_CR57","doi-asserted-by":"publisher","first-page":"3273","DOI":"10.1002\/ptr.6777","volume":"34","author":"R Feng","year":"2020","unstructured":"Feng R, He M-C, Li Q, Liang X-Q, Tang D-Z, Zhang J-L, et al. Phenol glycosides extract of Fructus Ligustri Lucidi attenuated depressive-like behaviors by suppressing neuroinflammation in hypothalamus of mice. Phytother Res. 2020;34:3273\u201386. https:\/\/doi.org\/10.1002\/ptr.6777.","journal-title":"Phytother Res"},{"key":"2227_CR58","doi-asserted-by":"publisher","first-page":"9139","DOI":"10.1021\/acs.jafc.0c04526","volume":"68","author":"S Guha","year":"2020","unstructured":"Guha S, Paul C, Alvarez S, Mine Y, Majumder K. Dietary \u03b3-glutamyl valine ameliorates TNF-\u03b1-induced vascular inflammation via endothelial calcium-sensing receptors. J Agric Food Chem. 2020;68:9139\u201349. https:\/\/doi.org\/10.1021\/acs.jafc.0c04526.","journal-title":"J Agric Food Chem"},{"key":"2227_CR59","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1111\/iej.13386","volume":"53","author":"M Kuramoto","year":"2020","unstructured":"Kuramoto M, Kawashima N, Tazawa K, Nara K, Fujii M, Noda S, et al. Mineral trioxide aggregate suppresses pro-inflammatory cytokine expression via the calcineurin\/nuclear factor of activated T cells\/early growth response 2 pathway in lipopolysaccharide-stimulated macrophages. Int Endod J. 2020;53:1653\u201365. https:\/\/doi.org\/10.1111\/iej.13386.","journal-title":"Int Endod J"},{"key":"2227_CR60","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1016\/j.cjca.2019.09.026","volume":"36","author":"Z Ren","year":"2020","unstructured":"Ren Z, Yang K, Zhao M, Liu W, Zhang X, Chi J, et al. Calcium-sensing receptor on neutrophil promotes myocardial apoptosis and fibrosis after acute myocardial infarction via NLRP3 inflammasome activation. Can J Cardiol. 2020;36:893\u2013905. https:\/\/doi.org\/10.1016\/j.cjca.2019.09.026.","journal-title":"Can J Cardiol"},{"key":"2227_CR61","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41419-022-04507-3","volume":"13","author":"S Murthy","year":"2022","unstructured":"Murthy S, Karkossa I, Schmidt C, Hoffmann A, Hagemann T, Rothe K, et al. Danger signal extracellular calcium initiates differentiation of monocytes into SPP1\/osteopontin-producing macrophages. Cell Death Dis Nat Publishing Group. 2022;13:1\u201315. https:\/\/doi.org\/10.1038\/s41419-022-04507-3.","journal-title":"Cell Death Dis Nat Publishing Group"},{"key":"2227_CR62","doi-asserted-by":"publisher","first-page":"1114129","DOI":"10.3389\/fimmu.2023.1114129","volume":"14","author":"Y Tang","year":"2023","unstructured":"Tang Y, Yu Y, Li R, Tao Z, Zhang L, Wang X, et al. Phenylalanine promotes alveolar macrophage pyroptosis via the activation of CaSR in ARDS. Front Immunol. 2023;14:1114129. https:\/\/doi.org\/10.3389\/fimmu.2023.1114129.","journal-title":"Front Immunol"},{"key":"2227_CR63","doi-asserted-by":"publisher","first-page":"G438","DOI":"10.1152\/ajpgi.00066.2023","volume":"326","author":"SM Abdulnour-Nakhoul","year":"2024","unstructured":"Abdulnour-Nakhoul SM, Kolls JK, Flemington EK, Ungerleider NA, Nakhoul HN, Song K, et al. Alterations in gene expression and microbiome composition upon calcium-sensing receptor deletion in the mouse esophagus. Am J Physiol Gastrointest Liver Physiol. 2024;326:G438\u201359. https:\/\/doi.org\/10.1152\/ajpgi.00066.2023.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"2227_CR64","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/S0049-3848(03)00381-5","volume":"110","author":"NR Ferreri","year":"2003","unstructured":"Ferreri NR, McGiff JC, Vio CP, Carroll MA. TNF\u03b1 regulates renal COX-2 in the rat thick ascending limb (TAL). Thromb Res. 2003;110:277\u201380. https:\/\/doi.org\/10.1016\/S0049-3848(03)00381-5.","journal-title":"Thromb Res"},{"key":"2227_CR65","doi-asserted-by":"publisher","first-page":"457","DOI":"10.3945\/an.111.000745","volume":"2","author":"GL Klein","year":"2011","unstructured":"Klein GL. Burns. Where has all the calcium (and Vitamin D) Gone? Adv Nutr. 2011;2:457\u201362. https:\/\/doi.org\/10.3945\/an.111.000745","journal-title":"Adv Nutr"},{"key":"2227_CR66","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.prostaglandins.2011.11.002","volume":"98","author":"NR Ferreri","year":"2012","unstructured":"Ferreri NR, Hao S, Pedraza PL, Escalante B, Vio CP. Eicosanoids and tumor necrosis factor-alpha in the kidney. Prostaglandins Other Lipid mediat. 2012;98:101\u20136. https:\/\/doi.org\/10.1016\/j.prostaglandins.2011.11.002.","journal-title":"Prostaglandins Other Lipid mediat"},{"key":"2227_CR67","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1097\/SHK.0000000000000261","volume":"43","author":"IA Hobai","year":"2015","unstructured":"Hobai IA, Edgecomb J, LaBarge K, Colucci WS. Dysregulation of intracellular calcium transporters in animal models of sepsis-induced cardiomyopathy. Shock. 2015;43:3\u201315. https:\/\/doi.org\/10.1097\/SHK.0000000000000261.","journal-title":"Shock"},{"key":"2227_CR68","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.semcdb.2015.11.006","volume":"49","author":"GN Hendy","year":"2016","unstructured":"Hendy GN, Canaff L. Calcium-sensing receptor, proinflammatory cytokines and calcium homeostasis. Semin Cell Dev Biol. 2016;49:37\u201343. https:\/\/doi.org\/10.1016\/j.semcdb.2015.11.006.","journal-title":"Semin Cell Dev Biol"},{"key":"2227_CR69","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.pupt.2016.09.010","volume":"41","author":"J Singh","year":"2016","unstructured":"Singh J, Shah R, Singh D. Inundation of asthma target research: untangling asthma riddles. Pulm Pharmacol Ther. 2016;41:60\u201385. https:\/\/doi.org\/10.1016\/j.pupt.2016.09.010.","journal-title":"Pulm Pharmacol Ther"},{"key":"2227_CR70","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.pharmthera.2016.04.002","volume":"164","author":"T Pera","year":"2016","unstructured":"Pera T, Penn RB. Bronchoprotection and bronchorelaxation in asthma: new targets, and new ways to target the old ones. Pharmacol Ther. 2016;164:82\u201396. https:\/\/doi.org\/10.1016\/j.pharmthera.2016.04.002.","journal-title":"Pharmacol Ther"},{"key":"2227_CR71","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.semcdb.2015.08.006","volume":"49","author":"GL Klein","year":"2016","unstructured":"Klein GL, Castro SM, Garofalo RP. The calcium-sensing receptor as a mediator of inflammation. Seminars Cell Dev Biology. 2016;49:52\u20136. https:\/\/doi.org\/10.1016\/j.semcdb.2015.08.006.","journal-title":"Seminars Cell Dev Biology"},{"key":"2227_CR72","doi-asserted-by":"publisher","first-page":"69","DOI":"10.3390\/biom8030069","volume":"8","author":"GL Klein","year":"2018","unstructured":"Klein GL. The role of calcium in inflammation-associated bone resorption. Biomolecules. 2018;8:69. https:\/\/doi.org\/10.3390\/biom8030069.","journal-title":"Biomolecules"},{"key":"2227_CR73","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.lfs.2018.08.016","volume":"209","author":"Y Guo","year":"2018","unstructured":"Guo Y, Yang X, He J, Liu J, Yang S, Dong H. Important roles of the Ca2+-sensing receptor in vascular health and disease. Life Sci. 2018;209:217\u201327. https:\/\/doi.org\/10.1016\/j.lfs.2018.08.016.","journal-title":"Life Sci"},{"key":"2227_CR74","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1080\/17476348.2020.1756779","volume":"14","author":"CJ Corrigan","year":"2020","unstructured":"Corrigan CJ. Calcilytics: a non-steroidal replacement for inhaled steroid and SABA\/LABA therapy of human asthma? Expert Rev Respir Med. 2020;14:807\u201316. https:\/\/doi.org\/10.1080\/17476348.2020.1756779.","journal-title":"Expert Rev Respir Med"},{"key":"2227_CR75","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1002\/ddr.21797","volume":"82","author":"S Yadav","year":"2021","unstructured":"Yadav S, Gupta K, Deshmukh K, Bhardwaj L, Dahiya A, Krishan P, et al. Calcium sensing receptor as a novel target for treatment of sepsis induced cardio-renal syndrome: Need for exploring mechanisms. Drug Dev Res. 2021;82:305\u20138. https:\/\/doi.org\/10.1002\/ddr.21797.","journal-title":"Drug Dev Res"},{"key":"2227_CR76","doi-asserted-by":"publisher","first-page":"2478","DOI":"10.3390\/ijms22052478","volume":"22","author":"SS Sundararaman","year":"2021","unstructured":"Sundararaman SS, van der Vorst EPC. Calcium-sensing receptor (CaSR), its impact on inflammation and the consequences on cardiovascular health. Int J Mol Sci Multidisciplinary Digit Publishing Inst. 2021;22:2478. https:\/\/doi.org\/10.3390\/ijms22052478.","journal-title":"Int J Mol Sci Multidisciplinary Digit Publishing Inst"},{"key":"2227_CR77","doi-asserted-by":"publisher","unstructured":"Iamartino L, Brandi ML. The calcium-sensing receptor in inflammation: Recent updates. Frontiers in Physiology [Internet]. 2022 [cited 2023 Nov 19];13. https:\/\/www.frontiersin.org\/articles\/https:\/\/doi.org\/10.3389\/fphys.2022.1059369. Accessed 19 Nov 2023.","DOI":"10.3389\/fphys.2022.1059369"},{"key":"2227_CR78","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1002\/ddr.21959","volume":"83","author":"A Sood","year":"2022","unstructured":"Sood A, Singh G, Singh TG, Gupta K. Pathological role of the calcium-sensing receptor in sepsis-induced hypotensive shock: Therapeutic possibilities and unanswered questions. Drug Dev Res. 2022;83:1241\u20135. https:\/\/doi.org\/10.1002\/ddr.21959.","journal-title":"Drug Dev Res"},{"key":"2227_CR79","doi-asserted-by":"publisher","first-page":"7851","DOI":"10.1021\/acs.jafc.2c01712","volume":"70","author":"S Guha","year":"2022","unstructured":"Guha S, Majumder K. Comprehensive review of \u03b3-glutamyl peptides (\u03b3-GPs) and their effect on inflammation concerning cardiovascular health. J Agric Food Chem Am Chem Soc. 2022;70:7851\u201370. https:\/\/doi.org\/10.1021\/acs.jafc.2c01712.","journal-title":"J Agric Food Chem Am Chem Soc"},{"key":"2227_CR80","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1006\/bbrc.1998.8648","volume":"246","author":"T Yamaguchi","year":"1998","unstructured":"Yamaguchi T, Olozak I, Chattopadhyay N, Butters RR, Kifor O, Scadden DT, et al. Expression of extracellular calcium (Ca2\u2009+\u2009o)-sensing receptor in human peripheral blood monocytes. Biochem Biophys Res Commun. 1998;246:501\u20136. https:\/\/doi.org\/10.1006\/bbrc.1998.8648.","journal-title":"Biochem Biophys Res Commun"},{"key":"2227_CR81","doi-asserted-by":"publisher","first-page":"110654","DOI":"10.1016\/j.mce.2019.110654","volume":"501","author":"A D\u2019Espessailles","year":"2020","unstructured":"D\u2019Espessailles A, Santillana N, Sanhueza S, Fuentes C, Cifuentes M. Calcium sensing receptor activation in THP-1 macrophages triggers NLRP3 inflammasome and human preadipose cell inflammation. Mol Cell Endocrinol. 2020;501:110654. https:\/\/doi.org\/10.1016\/j.mce.2019.110654.","journal-title":"Mol Cell Endocrinol"},{"key":"2227_CR82","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3389\/fphys.2016.00394","volume":"7","author":"GN Hendy","year":"2016","unstructured":"Hendy GN, Canaff L. Calcium-Sensing Receptor Gene: Regulation of Expression. Front Physiol. 2016;7:394. https:\/\/doi.org\/10.3389\/fphys.2016.00394.","journal-title":"Front Physiol"},{"key":"2227_CR83","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1134\/S0026893319050108","volume":"53","author":"KV Korneev","year":"2019","unstructured":"Korneev KV. Mouse models of sepsis and septic shock. Mol Biol. 2019;53:704\u201317. https:\/\/doi.org\/10.1134\/S0026893319050108.","journal-title":"Mol Biol"},{"key":"2227_CR84","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1080\/1061186X.2025.2546487","volume":"34","author":"O Akele","year":"2026","unstructured":"Akele O, Rana F, Acharya S, LeDoux D, Chalhoub M. Targeting lipopolysaccharides in gram-negative sepsis: therapeutic advances and challenges. J Drug Target Taylor Francis. 2026;34:202\u201314. https:\/\/doi.org\/10.1080\/1061186X.2025.2546487.","journal-title":"J Drug Target Taylor Francis"},{"key":"2227_CR85","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1007\/s11010-013-1637-3","volume":"379","author":"H Wang","year":"2013","unstructured":"Wang H, Liu X, Han G, Wang Z, Li X, Jiang Z, et al. LPS induces cardiomyocyte injury through calcium-sensing receptor. Mol Cell Biochem. 2013;379:153\u20139. https:\/\/doi.org\/10.1007\/s11010-013-1637-3.","journal-title":"Mol Cell Biochem"},{"key":"2227_CR86","doi-asserted-by":"publisher","first-page":"287","DOI":"10.4196\/kjpp.2020.24.4.287","volume":"24","author":"K-S Hong","year":"2020","unstructured":"Hong K-S, Lee M-G. Endothelial Ca2\u2009+\u2009signaling-dependent vasodilation through transient receptor potential channels. Korean J Physiol Pharmacol. 2020;24:287\u201398. https:\/\/doi.org\/10.4196\/kjpp.2020.24.4.287.","journal-title":"Korean J Physiol Pharmacol"},{"key":"2227_CR87","doi-asserted-by":"publisher","first-page":"4613","DOI":"10.3892\/mmr.2017.7164","volume":"16","author":"Y-Y Qu","year":"2017","unstructured":"Qu Y-Y, Wang L-M, Zhong H, Liu Y-M, Tang N, Zhu L-P, et al. TRPC1 stimulates calcium\u2013sensing receptor\u2013induced store\u2013operated Ca2\u2009+\u2009entry and nitric oxide production in endothelial cells. Mol Med Rep. 2017;16:4613\u20139. https:\/\/doi.org\/10.3892\/mmr.2017.7164.","journal-title":"Mol Med Rep"},{"key":"2227_CR88","doi-asserted-by":"publisher","unstructured":"Rybczynska A, Lehmann A, Jurska-Jasko A, Boblewski K, Orlewska C, Foks H et al. Hypertensive effect of calcilytic NPS 2143 administration in rats. 2006 [cited 2025 Sep 25]; https:\/\/doi.org\/10.1677\/joe.1.06924","DOI":"10.1677\/joe.1.06924"},{"key":"2227_CR89","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1002\/jbmr.3747","volume":"34","author":"MS Roberts","year":"2019","unstructured":"Roberts MS, Gafni RI, Brillante B, Guthrie LC, Streit J, Gash D, et al. Treatment of autosomal dominant hypocalcemia type 1 with the calcilytic NPSP795 (SHP635). J Bone Min Res. 2019;34:1609\u201318. https:\/\/doi.org\/10.1002\/jbmr.3747.","journal-title":"J Bone Min Res"},{"key":"2227_CR90","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1056\/NEJMc2302708","volume":"389","author":"RI Gafni","year":"2023","unstructured":"Gafni RI, Hartley IR, Roszko KL, Nemeth EF, Pozo KA, Lombardi E, et al. Efficacy and safety of encaleret in autosomal dominant hypocalcemia type 1. N Engl J Med. 2023;389:1245\u20137. https:\/\/doi.org\/10.1056\/NEJMc2302708.","journal-title":"N Engl J Med"},{"key":"2227_CR91","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.bone.2013.05.021","volume":"56","author":"S Caltabiano","year":"2013","unstructured":"Caltabiano S, Dollery CT, Hossain M, Kurtinecz MT, Desjardins JP, Favus MJ, et al. Characterization of the effect of chronic administration of a calcium-sensing receptor antagonist, ronacaleret, on renal calcium excretion and serum calcium in postmenopausal women. Bone. 2013;56:154\u201362. https:\/\/doi.org\/10.1016\/j.bone.2013.05.021.","journal-title":"Bone"},{"key":"2227_CR92","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/S0022-3565(24)29333-2","volume":"299","author":"EF Nemeth","year":"2001","unstructured":"Nemeth EF, Delmar EG, Heaton WL, Miller MA, Lambert LD, Conklin RL, et al. Calcilytic compounds: potent and selective Ca2\u2009+\u2009receptor antagonists that stimulate secretion of parathyroid hormone. J Pharmacol Exp Ther. 2001;299:323\u201331.","journal-title":"J Pharmacol Exp Ther"},{"key":"2227_CR93","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181e8ac36","author":"SM Smith","year":"2010","unstructured":"Smith SM. Magnesium activation of the calcium-sensing receptor, a mechanism to reduce infarction and vasospasm in subarachnoid hemorrhage. Crit Care Med. 2010. https:\/\/doi.org\/10.1097\/CCM.0b013e3181e8ac36. 38:2083.","journal-title":"Crit Care Med"},{"key":"2227_CR94","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.3390\/vaccines11061122","volume":"11","author":"F Saglietti","year":"2023","unstructured":"Saglietti F, Girombelli A, Marelli S, Vetrone F, Balzanelli MG, Tabaee Damavandi P. Role of magnesium in the intensive care unit and immunomodulation: a literature review. Vaccines (Basel). 2023;11:1122. https:\/\/doi.org\/10.3390\/vaccines11061122.","journal-title":"Vaccines (Basel)"},{"key":"2227_CR95","doi-asserted-by":"publisher","first-page":"9987","DOI":"10.1021\/acs.jafc.5b03749","volume":"63","author":"Y Mine","year":"2015","unstructured":"Mine Y, Zhang H. Calcium-sensing receptor (CaSR)-mediated anti-inflammatory effects of l-Amino acids in intestinal epithelial cells. J Agric Food Chem Am Chem Soc. 2015;63:9987\u201395. https:\/\/doi.org\/10.1021\/acs.jafc.5b03749.","journal-title":"J Agric Food Chem Am Chem Soc"},{"key":"2227_CR96","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1017\/S0007114518002891","volume":"120","author":"H Liu","year":"2018","unstructured":"Liu H, Tan B, Huang B, Li J, Wang J, Liao P, et al. Involvement of calcium-sensing receptor activation in the alleviation of intestinal inflammation in a piglet model by dietary aromatic amino acid supplementation. Br J Nutr. 2018;120:1321\u201331. https:\/\/doi.org\/10.1017\/S0007114518002891.","journal-title":"Br J Nutr"},{"key":"2227_CR97","doi-asserted-by":"publisher","first-page":"e17433","DOI":"10.7717\/peerj.17433","volume":"12","author":"Y Qin","year":"2024","unstructured":"Qin Y, Huang J, Ping X, Zheng H, Zhang K, Xu X, et al. No benefit of higher protein dosing in critically ill patients: a systematic review and meta-analysis of randomized controlled trials. PeerJ. 2024;12:e17433. https:\/\/doi.org\/10.7717\/peerj.17433.","journal-title":"PeerJ"},{"key":"2227_CR98","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38028.520995.63","author":"M Paul","year":"2004","unstructured":"Paul M, Benuri-Silbiger I, Soares-Weiser K, Leibovici L. \u03b2 lactam monotherapy versus \u03b2 lactam-aminoglycoside combination therapy for sepsis in immunocompetent patients: systematic review and meta-analysis of randomised trials. Br Med J Publishing Group. 2004. https:\/\/doi.org\/10.1136\/bmj.38028.520995.63. [cited 2025 Nov 13].","journal-title":"Br Med J Publishing Group"},{"key":"2227_CR99","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1681\/ASN.2004080631","volume":"16","author":"DT Ward","year":"2005","unstructured":"Ward DT, Maldonado-P\u00e9rez D, Hollins L, Riccardi D. Aminoglycosides induce acute cell signaling and chronic cell death in renal cells that express the calcium-sensing receptor. J Am Soc Nephrol. 2005;16:1236\u201344. https:\/\/doi.org\/10.1681\/ASN.2004080631.","journal-title":"J Am Soc Nephrol"},{"key":"2227_CR100","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1186\/s13054-020-03284-9","volume":"24","author":"J-F Llitjos","year":"2020","unstructured":"Llitjos J-F, Meslin S, Bredin S, Jamme M, P\u00e8ne F. Aminoglycosides for the treatment of septic shock: a propensity-based study. Crit Care. 2020;24:567. https:\/\/doi.org\/10.1186\/s13054-020-03284-9.","journal-title":"Crit Care"},{"key":"2227_CR101","doi-asserted-by":"publisher","first-page":"1516","DOI":"10.1056\/NEJMoa031633","volume":"350","author":"GA Block","year":"2004","unstructured":"Block GA, Martin KJ, de Francisco ALM, Turner SA, Avram MM, Suranyi MG, et al. Cinacalcet for secondary hyperparathyroidism in patients receiving hemodialysis. N Engl J Med. 2004;350:1516\u201325. https:\/\/doi.org\/10.1056\/NEJMoa031633.","journal-title":"N Engl J Med"},{"key":"2227_CR102","doi-asserted-by":"publisher","first-page":"e352","DOI":"10.1097\/CCM.0b013e31828cf436","volume":"41","author":"RD Collage","year":"2013","unstructured":"Collage RD, Howell GM, Zhang X, Stripay JL, Lee JS, Angus DC, et al. Calcium supplementation during sepsis exacerbates organ failure and mortality via calcium\/calmodulin-dependent protein kinase kinase signaling. Crit Care Med. 2013;41:e352\u2013360. https:\/\/doi.org\/10.1097\/CCM.0b013e31828cf436.","journal-title":"Crit Care Med"},{"key":"2227_CR103","doi-asserted-by":"publisher","first-page":"2520695","DOI":"10.1155\/2022\/2520695","volume":"2022","author":"W He","year":"2022","unstructured":"He W, Huang L, Luo H, Chen J, Li W, Zhang Y, et al. The positive and negative effects of calcium supplementation on mortality in septic ICU patients depend on disease severity: a retrospective study from the MIMIC-III. Crit Care Res Pract. 2022;2022:2520695. https:\/\/doi.org\/10.1155\/2022\/2520695.","journal-title":"Crit Care Res Pract"},{"key":"2227_CR104","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.1001\/jama.2014.13204","volume":"312","author":"K Amrein","year":"2014","unstructured":"Amrein K, Schnedl C, Holl A, Riedl R, Christopher KB, Pachler C, et al. Effect of high-dose vitamin D3 on hospital length of stay in critically ill patients with vitamin D deficiency: the VITdAL-ICU randomized clinical trial. JAMA. 2014;312:1520\u201330. https:\/\/doi.org\/10.1001\/jama.2014.13204.","journal-title":"JAMA"},{"key":"2227_CR105","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.3892\/ijmm.2016.2516","volume":"37","author":"AS Lee","year":"2016","unstructured":"Lee AS, Jung YJ, Thanh TN, Lee S, Kim W, Kang KP, et al. Paricalcitol attenuates lipopolysaccharide-induced myocardial inflammation by regulating the NF-\u03baB signaling pathway. Int J Mol Med Spandidos Publications. 2016;37:1023\u20139. https:\/\/doi.org\/10.3892\/ijmm.2016.2516.","journal-title":"Int J Mol Med Spandidos Publications"},{"key":"2227_CR106","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1111\/febs.17308","volume":"292","author":"Y Jiang","year":"2025","unstructured":"Jiang Y, Xing W, Li Z, Zhao D, Xiu B, Xi Y, et al. The calcium-sensing receptor alleviates endothelial inflammation in atherosclerosis through regulation of integrin \u03b21-NLRP3 inflammasome. FEBS J. 2025;292:191\u2013205. https:\/\/doi.org\/10.1111\/febs.17308.","journal-title":"FEBS J"},{"key":"2227_CR107","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/j.jare.2024.06.004","volume":"71","author":"Y Zhu","year":"2025","unstructured":"Zhu Y, Guo Y, Guo P, Zhang J, He Y, Xia Y, et al. Estrogen receptor \u03b2 activation alleviates inflammatory bowel disease by suppressing NLRP3-dependent IL-1\u03b2 production in macrophages via downregulation of intracellular calcium level. J Adv Res. 2025;71:571\u201384. https:\/\/doi.org\/10.1016\/j.jare.2024.06.004.","journal-title":"J Adv Res"},{"key":"2227_CR108","doi-asserted-by":"publisher","first-page":"509","DOI":"10.3390\/biom15040509","volume":"15","author":"K Wolffs","year":"2025","unstructured":"Wolffs K, Li R, Mansfield B, Pass DA, Bruce RT, Huang P, et al. Calcium-sensing receptor as a novel target for the treatment of idiopathic pulmonary fibrosis. Biomolecules. 2025;15:509. https:\/\/doi.org\/10.3390\/biom15040509.","journal-title":"Biomolecules"},{"key":"2227_CR109","doi-asserted-by":"publisher","first-page":"e70009","DOI":"10.1002\/biof.70009","volume":"51","author":"YM Yoon","year":"2025","unstructured":"Yoon YM, Woo S-M, Guim H, Kim JA. Effects of calciprotein particles on EMT induction in an in vitro 3D-cultured proximal tubule epithelial cell model of CKD. BioFactors. 2025;51:e70009. https:\/\/doi.org\/10.1002\/biof.70009.","journal-title":"BioFactors"}],"container-title":["Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00011-026-02227-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00011-026-02227-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00011-026-02227-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T20:02:19Z","timestamp":1776456139000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00011-026-02227-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,17]]},"references-count":109,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2227"],"URL":"https:\/\/doi.org\/10.1007\/s00011-026-02227-4","relation":{},"ISSN":["1420-908X"],"issn-type":[{"value":"1420-908X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,17]]},"assertion":[{"value":"1 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}},{"value":"All authors approved the manuscript for publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"99"}}