{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T05:00:54Z","timestamp":1775019654457,"version":"3.50.1"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflamm. Res."],"DOI":"10.1007\/s00011-026-02232-7","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T03:04:26Z","timestamp":1775012666000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The role of PD-1 and Tim-3 in regulating the suppressive activity of myeloid-derived suppressor cells in axial spondyloarthritis: association with clinical and laboratory parameters"],"prefix":"10.1007","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7987-2017","authenticated-orcid":false,"given":"Tamara Viktorovna","family":"Tyrinova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3290-7910","authenticated-orcid":false,"given":"Ludmila Vasilievna","family":"Sakhno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1065-9234","authenticated-orcid":false,"given":"Ivan Vladimirovich","family":"Savkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8997-3586","authenticated-orcid":false,"given":"Ekaterina Jakovlevna","family":"Shevela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2366-1667","authenticated-orcid":false,"given":"Marina Aleksandrovna","family":"Tikhonova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0980-1157","authenticated-orcid":false,"given":"Anastasiia Yurievna","family":"Morenkova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8633-0662","authenticated-orcid":false,"given":"Nadezhda Aleksandrovna","family":"Ilina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3797-6392","authenticated-orcid":false,"given":"Oksana Aleksandrovna","family":"Chumasova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7676-6166","authenticated-orcid":false,"given":"Nadezhda Sergeevna","family":"Shkaruba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3285-0568","authenticated-orcid":false,"given":"Anastasia Valerievna","family":"Fedorova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7080-777X","authenticated-orcid":false,"given":"Yulia Dmitrievna","family":"Kurochkina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6606-7185","authenticated-orcid":false,"given":"Vitaly Olegovich","family":"Omelchenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6275-2924","authenticated-orcid":false,"given":"Elena Alekseevna","family":"Letyagina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4890-0847","authenticated-orcid":false,"given":"Maxim Aleksandrovich","family":"Korolev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7213-7482","authenticated-orcid":false,"given":"Aleksey Eduardovich","family":"Sizikov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2346-6279","authenticated-orcid":false,"given":"Elena Removna","family":"Chernykh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,4,1]]},"reference":[{"key":"2232_CR1","doi-asserted-by":"publisher","first-page":"3753","DOI":"10.1038\/s41598-018-21856-2","volume":"8","author":"MJ Park","year":"2018","unstructured":"Park MJ, Lee SH, Kim EK, et al. Interleukin-10 produced by myeloid-derived suppressor cells is critical for the induction of Tregs and attenuation of rheumatoid inflammation in mice. Sci Rep. 2018;8:3753. https:\/\/doi.org\/10.1038\/s41598-018-21856-2.","journal-title":"Sci Rep"},{"key":"2232_CR2","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.clim.2014.04.006","volume":"153","author":"F Whitfield-Larry","year":"2014","unstructured":"Whitfield-Larry F, Felton J, Buse J, et al. Myeloid-derived suppressor cells are increased in frequency but not maximally suppressive in peripheral blood of Type 1 Diabetes Mellitus patients. Clin Immunol. 2014;153:156\u201364. https:\/\/doi.org\/10.1016\/j.clim.2014.04.006.","journal-title":"Clin Immunol"},{"key":"2232_CR3","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.clim.2015.02.001","volume":"157","author":"H Zhang","year":"2015","unstructured":"Zhang H, Wang S, Huang Y, et al. Myeloid-derived suppressor cells are proinflammatory and regulate collagen-induced arthritis through manipulating Th17 cell differentiation. Clin Immunol. 2015;157:175\u201386. https:\/\/doi.org\/10.1016\/j.clim.2015.02.001.","journal-title":"Clin Immunol"},{"key":"2232_CR4","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1186\/s13075-018-1654-4","volume":"20","author":"YF Liu","year":"2018","unstructured":"Liu YF, Zhuang KH, Chen B, et al. Expansion and activation of monocytic-myeloid-derived suppressor cell via STAT3\/arginase-I signaling in patients with ankylosing spondylitis. Arthritis Res Ther. 2018;20:168. https:\/\/doi.org\/10.1186\/s13075-018-1654-4.","journal-title":"Arthritis Res Ther"},{"key":"2232_CR5","doi-asserted-by":"publisher","first-page":"5474828","DOI":"10.1155\/2018\/5474828","volume":"2018","author":"J Zhu","year":"2018","unstructured":"Zhu J, Chen S, Wu L, et al. The expansion of myeloid-derived suppressor cells is associated with joint inflammation in rheumatic patients with arthritis. Biomed Res Int. 2018;2018:5474828. https:\/\/doi.org\/10.1155\/2018\/5474828.","journal-title":"Biomed Res Int"},{"key":"2232_CR6","doi-asserted-by":"publisher","first-page":"300","DOI":"10.47360\/1995-4484-2024-300-308","volume":"62","author":"TV Morenkova AYu, Tyrinova","year":"2024","unstructured":"Morenkova AYu, Tyrinova TV, Fedorova AV, et al. Myeloid-derived suppressor cells in axial spondyloarthritis patients with different types of therapy. Rheumatol Sci Pract. 2024;62:300\u20138. (In Russ.).","journal-title":"Rheumatol Sci Pract"},{"key":"2232_CR7","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1007\/s10147-016-0958-0","volume":"21","author":"S Chikuma","year":"2016","unstructured":"Chikuma S. Basics of PD-1 in self-tolerance, infection, and cancer immunity. Int J Clin Oncol. 2016;21:448\u201355. https:\/\/doi.org\/10.1007\/s10147-016-0958-0.","journal-title":"Int J Clin Oncol"},{"key":"2232_CR8","doi-asserted-by":"publisher","first-page":"645","DOI":"10.3390\/ijms18030645","volume":"18","author":"W Du","year":"2017","unstructured":"Du W, Yang M, Turner A, et al. TIM-3 as a target for cancer immunotherapy and mechanisms of action. Int J Mol Sci. 2017;18:645. https:\/\/doi.org\/10.3390\/ijms18030645.","journal-title":"Int J Mol Sci"},{"key":"2232_CR9","doi-asserted-by":"publisher","first-page":"8695157","DOI":"10.1155\/2018\/8695157","volume":"2018","author":"R Oca\u00f1a-Guzman","year":"2018","unstructured":"Oca\u00f1a-Guzman R, V\u00e1zquez-Bola\u00f1os L, Sada-Ovalle I. Receptors that inhibit macrophage activation: mechanisms and signals of regulation and tolerance. J Immunol Res. 2018;2018:8695157. https:\/\/doi.org\/10.1155\/2018\/8695157.","journal-title":"J Immunol Res"},{"key":"2232_CR10","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1051\/medsci\/20183403011","volume":"34","author":"C Granier","year":"2018","unstructured":"Granier C, Gey A, Dariane C, et al. Tim-3 - Biomarqueur et cible th\u00e9rapeutique en canc\u00e9rologie [Tim-3: a novel biomarker and therapeutic target in oncology]. Med Sci (Paris). 2018;34:231\u20137. (French.).","journal-title":"Med Sci (Paris)"},{"key":"2232_CR11","first-page":"296","volume":"21","author":"TA Tyrinova","year":"2024","unstructured":"Tyrinova TA, Sakhno LV, Morenkova, AYu, et al. Cytokine production by myeloid suppressor cells depending on the expression of PD-1 and Tim-3 receptors. J Ural Med Acad Sci. 2024;21:296\u2013307. (in Russ).","journal-title":"J Ural Med Acad Sci"},{"key":"2232_CR12","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1111\/j.1476-5381.2009.00291.x","volume":"158","author":"M Munder","year":"2009","unstructured":"Munder M. Arginase: an emerging key player in the mammalian immune system. Br J Pharmacol. 2009;158:638\u201351. https:\/\/doi.org\/10.1111\/j.1476-5381.2009.00291.x.","journal-title":"Br J Pharmacol"},{"key":"2232_CR13","doi-asserted-by":"publisher","first-page":"eaar3721","DOI":"10.1126\/scisignal.aar3721","volume":"11","author":"B Cai","year":"2018","unstructured":"Cai B, Kasikara C, Doran AC, et al. MerTK signaling in macrophages promotes the synthesis of inflammation resolution mediators by suppressing CaMKII activity. Sci Signal. 2018;11:eaar3721. https:\/\/doi.org\/10.1126\/scisignal.aar3721.","journal-title":"Sci Signal"},{"key":"2232_CR14","doi-asserted-by":"publisher","first-page":"78653","DOI":"10.18632\/oncotarget.11823","volume":"7","author":"MR Crittenden","year":"2016","unstructured":"Crittenden MR, Baird J, Friedman D, et al. Mertk on tumor macrophages is a therapeutic target to prevent tumor recurrence following radiation therapy. Oncotarget. 2016;7:78653\u201366. https:\/\/doi.org\/10.18632\/oncotarget.11823.","journal-title":"Oncotarget"},{"key":"2232_CR15","first-page":"2825","volume":"12","author":"F Pedregosa","year":"2011","unstructured":"Pedregosa F, Varoquaux G, Gramfort A, et al. Scikit-learn: machine learning in Python. J Mach Learn Res. 2011;12:2825\u201330.","journal-title":"J Mach Learn Res"},{"key":"2232_CR16","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1093\/biomet\/87.4.954","volume":"87","author":"IK Yeo","year":"2000","unstructured":"Yeo IK, Johnson RA. A new family of power transformations to improve normality or symmetry. Biometrika. 2000;87:954\u20139.","journal-title":"Biometrika"},{"key":"2232_CR17","first-page":"2579","volume":"9","author":"L Van der Maaten","year":"2008","unstructured":"Van der Maaten L, Hinton G. Visualizing data using t-SNE. J Mach Learn Res. 2008;9:2579\u2013605.","journal-title":"J Mach Learn Res"},{"key":"2232_CR18","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.it.2010.10.002","volume":"32","author":"T Condamine","year":"2011","unstructured":"Condamine T, Gabrilovich DI. Molecular mechanisms regulating myeloid-derived suppressor cell differentiation and function. Trends Immunol. 2011;32:19\u201325. https:\/\/doi.org\/10.1016\/j.it.2010.10.002.","journal-title":"Trends Immunol"},{"key":"2232_CR19","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1016\/j.jid.2015.12.036","volume":"136","author":"DC Soler","year":"2016","unstructured":"Soler DC, Young AB, Fiessinger L, et al. Increased, but functionally impaired, CD14(+) HLA-DR(-\/low) myeloid-derived suppressor cells in psoriasis: a mechanism of dysregulated T cells. J Invest Dermatol. 2016;136:798\u2013808. https:\/\/doi.org\/10.1016\/j.jid.2015.12.036.","journal-title":"J Invest Dermatol"},{"key":"2232_CR20","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1136\/annrheumdis-2014-205508","volume":"75","author":"C Guo","year":"2016","unstructured":"Guo C, Hu F, Yi H, et al. Myeloid-derived suppressor cells have a proinflammatory role in the pathogenesis of autoimmune arthritis. Ann Rheum Dis. 2016;75:278\u201385. https:\/\/doi.org\/10.1136\/annrheumdis-2014-205508.","journal-title":"Ann Rheum Dis"},{"key":"2232_CR21","doi-asserted-by":"publisher","first-page":"63","DOI":"10.4062\/biomolther.2018.201","volume":"27","author":"S Nam","year":"2019","unstructured":"Nam S, Lee A, Lim J, et al. Analysis of the expression and regulation of PD-1 protein on the surface of myeloid-derived suppressor cells (MDSCs). Biomol Ther (Seoul). 2019;27:63\u201370. https:\/\/doi.org\/10.4062\/biomolther.2018.201.","journal-title":"Biomol Ther (Seoul)"},{"key":"2232_CR22","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/nm.2106","volume":"16","author":"EA Said","year":"2010","unstructured":"Said EA, Dupuy FP, Trautmann L, et al. Programmed death-1-induced interleukin-10 production by monocytes impairs CD4\u2009+\u2009T cell activation during HIV infection. Nat Med. 2010;16:452\u20139. https:\/\/doi.org\/10.1038\/nm.2106.","journal-title":"Nat Med"},{"key":"2232_CR23","doi-asserted-by":"publisher","first-page":"449","DOI":"10.3389\/fimmu.2013.00449","volume":"4","author":"G Han","year":"2013","unstructured":"Han G, Chen G, Shen B, et al. Tim-3: an activation marker and activation limiter of innate immune cells. Front Immunol. 2013;4:449. https:\/\/doi.org\/10.3389\/fimmu.2013.00449.","journal-title":"Front Immunol"},{"key":"2232_CR24","doi-asserted-by":"publisher","first-page":"e12755","DOI":"10.1111\/sji.12755","volume":"89","author":"J Wang","year":"2019","unstructured":"Wang J, Li C, Fu J, et al. Tim-3 regulates inflammatory cytokine expression and Th17 cell response induced by monocytes from patients with chronic hepatitis B. Scand J Immunol. 2019;89:e12755. https:\/\/doi.org\/10.1111\/sji.12755.","journal-title":"Scand J Immunol"},{"key":"2232_CR25","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.placenta.2021.08.060","volume":"114","author":"S Dong","year":"2021","unstructured":"Dong S, Shah NK, He J, et al. The abnormal expression of Tim-3 is involved in the regulation of myeloid-derived suppressor cells and its correlation with preeclampsia. Placenta. 2021;114:108\u201314. https:\/\/doi.org\/10.1016\/j.placenta.2021.08.060.","journal-title":"Placenta"}],"container-title":["Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00011-026-02232-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00011-026-02232-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00011-026-02232-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T03:04:32Z","timestamp":1775012672000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00011-026-02232-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,1]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2232"],"URL":"https:\/\/doi.org\/10.1007\/s00011-026-02232-7","relation":{},"ISSN":["1420-908X"],"issn-type":[{"value":"1420-908X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,1]]},"assertion":[{"value":"12 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 March 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 March 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Approval was obtained from the ethics committee of Federal State Budgetary Scientific Institution Research Institute of Fundamental and Clinical Immunology (Protocol No. 1, approved February 9, 2021). The procedures used in this study adhere to the tenets of the Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical considerations"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}],"article-number":"81"}}