{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T21:49:19Z","timestamp":1776462559949,"version":"3.51.2"},"reference-count":134,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82471312"],"award-info":[{"award-number":["82471312"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Chongqing Natural Science Foundation Joint Fund for Innovation and Development","award":["CSTB2023NSCQ-LZX0041"],"award-info":[{"award-number":["CSTB2023NSCQ-LZX0041"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflamm. Res."],"DOI":"10.1007\/s00011-026-02243-4","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T19:49:41Z","timestamp":1776455381000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Roles of mitophagy and immune infiltration in Parkinson\u2019s disease: new perspectives from bioinformatics analysis and A53T transgenic mice"],"prefix":"10.1007","volume":"75","author":[{"given":"Xuesong","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianwen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junwei","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ningning","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zongduo","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,4,17]]},"reference":[{"issue":"3","key":"2243_CR1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-05672-9","volume":"14","author":"P Calabresi","year":"2023","unstructured":"Calabresi P, Mechelli A, Natale G, Volpicelli-Daley L, Di Lazzaro G, Ghiglieri V. Alpha-synuclein in Parkinson\u2019s disease and other synucleinopathies: from overt neurodegeneration back to early synaptic dysfunction. Cell Death Dis. 2023;14(3):176.","journal-title":"Cell Death Dis"},{"issue":"10423","key":"2243_CR2","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/S0140-6736(23)01478-2","volume":"403","author":"HR Morris","year":"2024","unstructured":"Morris HR, Spillantini MG, Sue CM, Williams-Gray CH. The pathogenesis of Parkinson\u2019s disease. Lancet. 2024;403(10423):293\u2013304.","journal-title":"Lancet"},{"issue":"1","key":"2243_CR3","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/S1474-4422(21)00330-6","volume":"21","author":"D Weintraub","year":"2022","unstructured":"Weintraub D, Aarsland D, Chaudhuri KR, Dobkin RD, Leentjens AF, Rodriguez-Violante M, et al. The neuropsychiatry of Parkinson\u2019s disease: advances and challenges. Lancet Neurol. 2022;21(1):89\u2013102.","journal-title":"Lancet Neurol"},{"issue":"7","key":"2243_CR4","doi-asserted-by":"publisher","first-page":"e464","DOI":"10.1016\/S2666-7568(24)00094-1","volume":"5","author":"J Zhu","year":"2024","unstructured":"Zhu J, Cui Y, Zhang J, Yan R, Su D, Zhao D, et al. Temporal trends in the prevalence of Parkinson\u2019s disease from 1980 to 2023: a systematic review and meta-analysis. Lancet Healthy Longev. 2024;5(7):e464\u201379.","journal-title":"Lancet Healthy Longev"},{"key":"2243_CR5","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2024-080952","volume":"388","author":"D Su","year":"2025","unstructured":"Su D, Cui Y, He C, Yin P, Bai R, Zhu J, et al. Projections for prevalence of Parkinson\u2019s disease and its driving factors in 195 countries and territories to 2050: modelling study of Global Burden of Disease Study 2021. BMJ. 2025;388:e080952.","journal-title":"BMJ"},{"issue":"12","key":"2243_CR6","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1038\/s41582-024-01034-x","volume":"20","author":"F Stocchi","year":"2024","unstructured":"Stocchi F, Bravi D, Emmi A, Antonini A. Parkinson disease therapy: current strategies and future research priorities. Nat Rev Neurol. 2024;20(12):695\u2013707.","journal-title":"Nat Rev Neurol"},{"issue":"10","key":"2243_CR7","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/j.tcb.2016.05.008","volume":"26","author":"TN Nguyen","year":"2016","unstructured":"Nguyen TN, Padman BS, Lazarou M. Deciphering the molecular signals of PINK1\/Parkin mitophagy. Trends Cell Biol. 2016;26(10):733\u201344.","journal-title":"Trends Cell Biol"},{"issue":"4","key":"2243_CR8","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.tibs.2020.11.007","volume":"46","author":"AB Malpartida","year":"2021","unstructured":"Malpartida AB, Williamson M, Narendra DP, Wade-Martins R, Ryan BJ. Mitochondrial dysfunction and mitophagy in Parkinson\u2019s disease: from mechanism to therapy. Trends Biochem Sci. 2021;46(4):329\u201343.","journal-title":"Trends Biochem Sci"},{"issue":"5","key":"2243_CR9","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.1080\/15548627.2022.2139080","volume":"19","author":"R Han","year":"2023","unstructured":"Han R, Liu Y, Li S, Li XJ, Yang W. PINK1-PRKN mediated mitophagy: differences between in vitro and in vivo models. Autophagy. 2023;19(5):1396\u2013405.","journal-title":"Autophagy"},{"issue":"1","key":"2243_CR10","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-020-01062-w","volume":"8","author":"PMJ Quinn","year":"2020","unstructured":"Quinn PMJ, Moreira PI, Ambr\u00f3sio AF, Alves CH. PINK1\/PARKIN signalling in neurodegeneration and neuroinflammation. Acta Neuropathol Commun. 2020;8(1):189.","journal-title":"Acta Neuropathol Commun"},{"issue":"1","key":"2243_CR11","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s13024-020-00367-7","volume":"15","author":"P Ge","year":"2020","unstructured":"Ge P, Dawson VL, Dawson TM. PINK1 and Parkin mitochondrial quality control: a source of regional vulnerability in Parkinson\u2019s disease. Mol Neurodegener. 2020;15(1):20.","journal-title":"Mol Neurodegener"},{"issue":"2","key":"2243_CR12","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1042\/BST20211107","volume":"50","author":"S Masaldan","year":"2022","unstructured":"Masaldan S, Callegari S, Dewson G. Therapeutic targeting of mitophagy in Parkinson\u2019s disease. Biochem Soc Trans. 2022;50(2):783\u201397.","journal-title":"Biochem Soc Trans"},{"key":"2243_CR13","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1016\/j.freeradbiomed.2024.10.281","volume":"225","author":"X Han","year":"2024","unstructured":"Han X, Zhang B, Gong Q, Liu T, Wang C, Sun Y, et al. The tolerable upper intake level of manganese alleviates Parkinson-like motor performance and neuronal loss by activating mitophagy. Free Radic Biol Med. 2024;225:665\u201376.","journal-title":"Free Radic Biol Med"},{"issue":"2","key":"2243_CR14","doi-asserted-by":"publisher","first-page":"2250","DOI":"10.1007\/s12035-024-04367-2","volume":"62","author":"J Zhao","year":"2025","unstructured":"Zhao J, Wang J, Zhao K, Yang S, Dong J, Zhang Y, et al. Palmatine ameliorates motor deficits and dopaminergic neuron loss by regulating NLRP3 inflammasome through mitophagy in Parkinson\u2019s disease model mice. Mol Neurobiol. 2025;62(2):2250\u201363.","journal-title":"Mol Neurobiol"},{"key":"2243_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154250","volume":"104","author":"LK Wu","year":"2022","unstructured":"Wu LK, Agarwal S, Kuo CH, Kung YL, Day CH, Lin PY, et al. Artemisia leaf extract protects against neuron toxicity by TRPML1 activation and promoting autophagy\/mitophagy clearance in both in vitro and in vivo models of MPP+\/MPTP-induced Parkinson\u2019s disease. Phytomedicine. 2022;104:154250.","journal-title":"Phytomedicine"},{"key":"2243_CR16","doi-asserted-by":"publisher","first-page":"1250532","DOI":"10.3389\/fnins.2023.1250532","volume":"17","author":"K Hou","year":"2023","unstructured":"Hou K, Liu T, Li J, Xian M, Sun L, Wei J. Liquid-liquid phase separation regulates alpha-synuclein aggregate and mitophagy in Parkinson\u2019s disease. Front Neurosci. 2023;17:1250532.","journal-title":"Front Neurosci"},{"issue":"11","key":"2243_CR17","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1038\/s41419-023-06251-8","volume":"14","author":"O Lurette","year":"2023","unstructured":"Lurette O, Mart\u00edn-Jim\u00e9nez R, Khan M, Sheta R, Jean S, Schofield M, et al. Aggregation of alpha-synuclein disrupts mitochondrial metabolism and induce mitophagy via cardiolipin externalization. Cell Death Dis. 2023;14(11):729.","journal-title":"Cell Death Dis"},{"issue":"Database issue","key":"2243_CR18","first-page":"D991","volume":"41","author":"T Barrett","year":"2013","unstructured":"Barrett T, Wilhite SE, Ledoux P, Evangelista C, Kim IF, Tomashevsky M, et al. NCBI GEO: archive for functional genomics data sets\u2013update. Nucleic Acids Res. 2013;41(Database issue):D991\u20135.","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"2243_CR19","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s10048-006-0077-6","volume":"8","author":"DC Duke","year":"2007","unstructured":"Duke DC, Moran LB, Pearce RK, Graeber MB. The medial and lateral substantia nigra in Parkinson\u2019s disease: mRNA profiles associated with higher brain tissue vulnerability. Neurogenetics. 2007;8(2):83\u201394.","journal-title":"Neurogenetics"},{"issue":"1","key":"2243_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10048-005-0020-2","volume":"7","author":"LB Moran","year":"2006","unstructured":"Moran LB, Duke DC, Deprez M, Dexter DT, Pearce RK, Graeber MB. Whole genome expression profiling of the medial and lateral substantia nigra in Parkinson\u2019s disease. Neurogenetics. 2006;7(1):1\u201311.","journal-title":"Neurogenetics"},{"issue":"52","key":"2243_CR21","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3001059","volume":"2","author":"B Zheng","year":"2010","unstructured":"Zheng B, Liao Z, Locascio JJ, Lesniak KA, Roderick SS, Watt ML, et al. PGC-1\u03b1, a potential therapeutic target for early intervention in Parkinson\u2019s disease. Sci Transl Med. 2010;2(52):52ra73.","journal-title":"Sci Transl Med"},{"key":"2243_CR22","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1471-2105-14-7","volume":"14","author":"S H\u00e4nzelmann","year":"2013","unstructured":"H\u00e4nzelmann S, Castelo R, Guinney J. GSVA: gene set variation analysis for microarray and RNA-seq data. BMC Bioinform. 2013;14:7.","journal-title":"BMC Bioinform"},{"issue":"3","key":"2243_CR23","volume":"2","author":"T Wu","year":"2021","unstructured":"Wu T, Hu E, Xu S, Chen M, Guo P, Dai Z, et al. clusterProfiler 4.0: a universal enrichment tool for interpreting omics data. Innovation (Camb). 2021;2(3):100141.","journal-title":"Innovation (Camb)"},{"issue":"4","key":"2243_CR24","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1093\/bioinformatics\/btu684","volume":"31","author":"G Yu","year":"2015","unstructured":"Yu G, Wang LG, Yan GR, He QY. DOSE: an R\/Bioconductor package for disease ontology semantic and enrichment analysis. Bioinformatics. 2015;31(4):608\u20139.","journal-title":"Bioinformatics"},{"key":"2243_CR25","doi-asserted-by":"publisher","first-page":"1.30.1","DOI":"10.1002\/cpbi.5","volume":"54","author":"G Stelzer","year":"2016","unstructured":"Stelzer G, Rosen N, Plaschkes I, Zimmerman S, Twik M, Fishilevich S, et al. The GeneCards Suite: from gene data mining to disease genome sequence analyses. Curr Protoc Bioinform. 2016;54:1.30.1-1.30.33.","journal-title":"Curr Protoc Bioinform"},{"issue":"D1","key":"2243_CR26","doi-asserted-by":"publisher","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","volume":"51","author":"D Szklarczyk","year":"2023","unstructured":"Szklarczyk D, Kirsch R, Koutrouli M, Nastou K, Mehryary F, Hachilif R, et al. The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest. Nucleic Acids Res. 2023;51(D1):D638-d646.","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"2243_CR27","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1021\/acs.jproteome.8b00702","volume":"18","author":"NT Doncheva","year":"2019","unstructured":"Doncheva NT, Morris JH, Gorodkin J, Jensen LJ. Cytoscape StringApp: network analysis and visualization of proteomics data. J Proteome Res. 2019;18(2):623\u201332.","journal-title":"J Proteome Res"},{"issue":"Web Server issu","key":"2243_CR28","doi-asserted-by":"publisher","first-page":"W214","DOI":"10.1093\/nar\/gkq537","volume":"38","author":"D Warde-Farley","year":"2010","unstructured":"Warde-Farley D, Donaldson SL, Comes O, Zuberi K, Badrawi R, Chao P, et al. The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function. Nucleic Acids Res. 2010;38(Web Server issue):W214\u201320.","journal-title":"Nucleic Acids Res"},{"issue":"W1","key":"2243_CR29","doi-asserted-by":"publisher","first-page":"W234","DOI":"10.1093\/nar\/gkz240","volume":"47","author":"G Zhou","year":"2019","unstructured":"Zhou G, Soufan O, Ewald J, Hancock REW, Basu N, Xia J. NetworkAnalyst 3.0: a visual analytics platform for comprehensive gene expression profiling and meta-analysis. Nucleic Acids Res. 2019;47(W1):W234-w241.","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"2243_CR30","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.celrep.2016.12.019","volume":"18","author":"P Charoentong","year":"2017","unstructured":"Charoentong P, Finotello F, Angelova M, Mayer C, Efremova M, Rieder D, et al. Pan-cancer immunogenomic analyses reveal genotype-immunophenotype relationships and predictors of response to checkpoint blockade. Cell Rep. 2017;18(1):248\u201362.","journal-title":"Cell Rep"},{"issue":"6","key":"2243_CR31","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1093\/bioinformatics\/bts034","volume":"28","author":"JT Leek","year":"2012","unstructured":"Leek JT, Johnson WE, Parker HS, Jaffe AE, Storey JD. The sva package for removing batch effects and other unwanted variation in high-throughput experiments. Bioinformatics. 2012;28(6):882\u20133.","journal-title":"Bioinformatics"},{"issue":"5","key":"2243_CR32","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1038\/s41593-022-01061-1","volume":"25","author":"T Kamath","year":"2022","unstructured":"Kamath T, Abdulraouf A, Burris SJ, Langlieb J, Gazestani V, Nadaf NM, et al. Single-cell genomic profiling of human dopamine neurons identifies a population that selectively degenerates in Parkinson\u2019s disease. Nat Neurosci. 2022;25(5):588\u201395.","journal-title":"Nat Neurosci"},{"issue":"8","key":"2243_CR33","doi-asserted-by":"publisher","first-page":"2847","DOI":"10.1093\/brain\/awaf066","volume":"148","author":"G Moquin-Beaudry","year":"2025","unstructured":"Moquin-Beaudry G, Andriamboavonjy L, Audet S, Hamilton LK, Duquette A, Chouinard S, et al. Mapping the peripheral immune landscape of Parkinson\u2019s disease patients with single-cell sequencing. Brain. 2025;148(8):2847\u201360.","journal-title":"Brain"},{"issue":"2","key":"2243_CR34","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/s41587-023-01767-y","volume":"42","author":"Y Hao","year":"2024","unstructured":"Hao Y, Stuart T, Kowalski MH, Choudhary S, Hoffman P, Hartman A, et al. Dictionary learning for integrative, multimodal and scalable single-cell analysis. Nat Biotechnol. 2024;42(2):293\u2013304.","journal-title":"Nat Biotechnol"},{"issue":"3","key":"2243_CR35","first-page":"346","volume":"3","author":"J Xu","year":"2023","unstructured":"Xu J, Farsad HL, Hou Y, Barclay K, Lopez BA, Yamada S, et al. Human striatal glia differentially contribute to AD- and PD-specific neurodegeneration. Nat Aging. 2023;3(3):346\u201365.","journal-title":"Nat Aging"},{"issue":"D1","key":"2243_CR36","doi-asserted-by":"publisher","first-page":"D721","DOI":"10.1093\/nar\/gky900","volume":"47","author":"X Zhang","year":"2019","unstructured":"Zhang X, Lan Y, Xu J, Quan F, Zhao E, Deng C, et al. Cell Marker: a manually curated resource of cell markers in human and mouse. Nucleic Acids Res. 2019;47(D1):D721-d728.","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"2243_CR37","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1902\/jop.1990.61.3.180","volume":"61","author":"TE Van Dyke","year":"1990","unstructured":"Van Dyke TE, Warbington M, Gardner M, Offenbacher S. Neutrophil surface protein markers as indicators of defective chemotaxis in LJP. J Periodontol. 1990;61(3):180\u20134.","journal-title":"J Periodontol"},{"issue":"5","key":"2243_CR38","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1007\/s10384-011-0060-0","volume":"55","author":"HF Wang","year":"2011","unstructured":"Wang HF, Liu JL, Jiang XL, Lu JM, Li XL, Song XJ. Suppressive effect of aqueous humor on lipopolysaccharide-induced dendritic cell maturation. Jpn J Ophthalmol. 2011;55(5):558\u201364.","journal-title":"Jpn J Ophthalmol"},{"issue":"2","key":"2243_CR39","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1097\/QAI.0b013e31829d4d50","volume":"64","author":"Y Guo","year":"2013","unstructured":"Guo Y, Siewe B, Epeldegui M, Detels R, Landay AL, Mart\u00ednez-Maza O. TLR2-activated B cells are phenotypically similar to the abnormal circulating B cells seen preceding the diagnosis of AIDS-related NHL diagnosis. J Acquir Immune Defic Syndr. 2013;64(2):204\u201310.","journal-title":"J Acquir Immune Defic Syndr"},{"key":"2243_CR40","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21020678","author":"DG Walker","year":"2020","unstructured":"Walker DG, Tang TM, Mendsaikhan A, Tooyama I, Serrano GE, Sue LI, et al. Patterns of expression of purinergic receptor P2RY12, a putative marker for non-activated microglia, in aged and Alzheimer\u2019s disease brains. Int J Mol Sci. 2020. https:\/\/doi.org\/10.3390\/ijms21020678.","journal-title":"Int J Mol Sci"},{"issue":"7926","key":"2243_CR41","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1038\/s41586-022-05111-3","volume":"609","author":"Z Wei","year":"2022","unstructured":"Wei Z, Oh J, Flavell RA, Crawford JM. LACC1 bridges NOS2 and polyamine metabolism in inflammatory macrophages. Nature. 2022;609(7926):348\u201353.","journal-title":"Nature"},{"issue":"5","key":"2243_CR42","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1080\/15548627.2020.1749490","volume":"17","author":"Y Hu","year":"2021","unstructured":"Hu Y, Chen H, Zhang L, Lin X, Li X, Zhuang H, et al. The AMPK-MFN2 axis regulates MAM dynamics and autophagy induced by energy stresses. Autophagy. 2021;17(5):1142\u201356.","journal-title":"Autophagy"},{"issue":"13","key":"2243_CR43","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.15252\/embj.201593102","volume":"35","author":"W Wu","year":"2016","unstructured":"Wu W, Lin C, Wu K, Jiang L, Wang X, Li W, et al. FUNDC1 regulates mitochondrial dynamics at the ER-mitochondrial contact site under hypoxic conditions. EMBO J. 2016;35(13):1368\u201384.","journal-title":"EMBO J"},{"key":"2243_CR44","doi-asserted-by":"publisher","DOI":"10.3390\/biom11020222","author":"V Manganelli","year":"2021","unstructured":"Manganelli V, Capozzi A, Recalchi S, Riitano G, Mattei V, Longo A, et al. The role of cardiolipin as a scaffold mitochondrial phospholipid in autophagosome formation: in vitro evidence. Biomolecules Basel. 2021. https:\/\/doi.org\/10.3390\/biom11020222.","journal-title":"Biomolecules Basel"},{"issue":"6","key":"2243_CR45","doi-asserted-by":"publisher","first-page":"2624","DOI":"10.7150\/thno.105591","volume":"15","author":"X Liu","year":"2025","unstructured":"Liu X, Zhao J, Sun Q, Xue Z, Tang Z, Liu W, et al. Calnexin promotes glioblastoma progression by inducing protective mitophagy through the MEK\/ERK\/BNIP3 pathway. Theranostics. 2025;15(6):2624\u201348.","journal-title":"Theranostics"},{"issue":"5","key":"2243_CR46","doi-asserted-by":"publisher","first-page":"e98410","DOI":"10.1172\/jci.insight.98410","volume":"3","author":"J Jung","year":"2018","unstructured":"Jung J, Eggleton P, Robinson A, Wang J, Gutowski N, Holley J, et al. Calnexin is necessary for T cell transmigration into the central nervous system. JCI Insight. 2018;3(5):e98410.","journal-title":"JCI Insight"},{"issue":"12","key":"2243_CR47","doi-asserted-by":"publisher","first-page":"16662","DOI":"10.1096\/fj.202001539RR","volume":"34","author":"T Paskevicius","year":"2020","unstructured":"Paskevicius T, Jung J, Pujol M, Eggleton P, Qin W, Robinson A, et al. The Fabp5\/calnexin complex is a prerequisite for sensitization of mice to experimental autoimmune encephalomyelitis. FASEB J. 2020;34(12):16662\u201375.","journal-title":"FASEB J"},{"issue":"8","key":"2243_CR48","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202100235R","volume":"35","author":"J Zheng","year":"2021","unstructured":"Zheng J, Yang T, Gao S, Cheng M, Shao Y, Xi Y, et al. miR-148a-3p silences the CANX\/MHC-I pathway and impairs CD8(+) T cell-mediated immune attack in colorectal cancer. FASEB J. 2021;35(8):e21776.","journal-title":"FASEB J"},{"issue":"1","key":"2243_CR49","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-04435-0","volume":"15","author":"S Menon","year":"2025","unstructured":"Menon S, Rais N. Meta-analysis and in-silico functional characterization of the SNCA variant rs356220 in Parkinson\u2019s disease. Sci Rep. 2025;15(1):23358.","journal-title":"Sci Rep"},{"issue":"10","key":"2243_CR50","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.4161\/auto.7.10.15904","volume":"7","author":"JN Le Grand","year":"2011","unstructured":"Le Grand JN, Chakrama FZ, Seguin-Py S, Fraichard A, Delage-Mourroux R, Jouvenot M, et al. GABARAPL1 (GEC1): Original or copycat? Autophagy. 2011;7(10):1098\u2013107.","journal-title":"Autophagy"},{"issue":"6","key":"2243_CR51","doi-asserted-by":"publisher","first-page":"986","DOI":"10.4161\/auto.28390","volume":"10","author":"M Boyer-Guittaut","year":"2014","unstructured":"Boyer-Guittaut M, Poillet L, Liang Q, B\u00f4le-Richard E, Ouyang X, Benavides GA, et al. The role of GABARAPL1\/GEC1 in autophagic flux and mitochondrial quality control in MDA-MB-436 breast cancer cells. Autophagy. 2014;10(6):986\u20131003.","journal-title":"Autophagy"},{"issue":"7","key":"2243_CR52","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1011548","volume":"19","author":"MT Vo","year":"2023","unstructured":"Vo MT, Choi CY, Choi YB. The mitophagy receptor NIX induces vIRF-1 oligomerization and interaction with GABARAPL1 for the promotion of HHV-8 reactivation-induced mitophagy. PLoS Pathog. 2023;19(7):e1011548.","journal-title":"PLoS Pathog"},{"key":"2243_CR53","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2024.110855","volume":"389","author":"J Si","year":"2024","unstructured":"Si J, Sun L, Qin Y, Peng L, Gong Y, Gao C, et al. Cannabinoids improve mitochondrial function in skeletal muscle of exhaustive exercise training rats by inhibiting mitophagy through the PINK1\/PARKIN and BNIP3 pathways. Chem Biol Interact. 2024;389:110855.","journal-title":"Chem Biol Interact"},{"issue":"1","key":"2243_CR54","doi-asserted-by":"publisher","DOI":"10.1186\/s41065-025-00424-5","volume":"162","author":"JY Li","year":"2025","unstructured":"Li JY, Chen HK, Huang YH, Zhi YP, Li YE, Lin KY, et al. Identification of mitophagy-related genes in patients with acute myocardial infarction. Hereditas. 2025;162(1):70.","journal-title":"Hereditas"},{"key":"2243_CR55","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2023.1101216","volume":"15","author":"T Mei","year":"2023","unstructured":"Mei T, Li Y, Ordu\u00f1a Dolado A, Li Z, Andersson R, Berliocchi L, et al. Pooled analysis of frontal lobe transcriptomic data identifies key mitophagy gene changes in Alzheimer\u2019s disease brain. Front Aging Neurosci. 2023;15:1101216.","journal-title":"Front Aging Neurosci"},{"issue":"20","key":"2243_CR56","doi-asserted-by":"publisher","first-page":"12123","DOI":"10.3390\/ijms232012123","volume":"23","author":"C Liu","year":"2022","unstructured":"Liu C, Wu Z, Wang L, Yang Q, Huang J, Huang J. A mitophagy-related gene signature for subtype identification and prognosis prediction of hepatocellular carcinoma. Int J Mol Sci. 2022;23(20):12123.","journal-title":"Int J Mol Sci"},{"key":"2243_CR57","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2020.144454","volume":"738","author":"S El Haddad","year":"2020","unstructured":"El Haddad S, Serrano A, Moal F, Normand T, Robin C, Charpentier S, et al. Disturbed expression of autophagy genes in blood of Parkinson\u2019s disease patients. Gene. 2020;738:144454.","journal-title":"Gene"},{"issue":"2","key":"2243_CR58","doi-asserted-by":"publisher","first-page":"707","DOI":"10.3390\/ijms25020707","volume":"25","author":"M Salemi","year":"2024","unstructured":"Salemi M, Ravo M, Lanza G, Schillaci FA, Ventola GM, Marchese G, et al. Gene expression profiling of post mortem midbrain of Parkinson\u2019s disease patients and healthy controls. Int J Mol Sci. 2024;25(2):707.","journal-title":"Int J Mol Sci"},{"issue":"6","key":"2243_CR59","doi-asserted-by":"publisher","first-page":"801","DOI":"10.4161\/cbt.7.6.6281","volume":"7","author":"F Cappello","year":"2008","unstructured":"Cappello F, Conway de Macario E, Maras\u00e0 L, Zummo G, Macario AJ. Hsp60 expression, new locations, functions and perspectives for cancer diagnosis and therapy. Cancer Biol Ther. 2008;7(6):801\u20139.","journal-title":"Cancer Biol Ther"},{"key":"2243_CR60","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2022.100888","volume":"65","author":"B Parma","year":"2022","unstructured":"Parma B, Wurdak H, Ceppi P. Harnessing mitochondrial metabolism and drug resistance in non-small cell lung cancer and beyond by blocking heat-shock proteins. Drug Resist Updat. 2022;65:100888.","journal-title":"Drug Resist Updat"},{"issue":"10","key":"2243_CR61","doi-asserted-by":"publisher","first-page":"2962","DOI":"10.1080\/15548627.2020.1848130","volume":"17","author":"CJ Choong","year":"2021","unstructured":"Choong CJ, Okuno T, Ikenaka K, Baba K, Hayakawa H, Koike M, et al. Alternative mitochondrial quality control mediated by extracellular release. Autophagy. 2021;17(10):2962\u201374.","journal-title":"Autophagy"},{"issue":"12","key":"2243_CR62","doi-asserted-by":"publisher","first-page":"4102","DOI":"10.1080\/15548627.2021.1904488","volume":"17","author":"H Song","year":"2021","unstructured":"Song H, Tian X, Liu D, Liu M, Liu Y, Liu J, et al. CREG1 improves the capacity of the skeletal muscle response to exercise endurance via modulation of mitophagy. Autophagy. 2021;17(12):4102\u201318.","journal-title":"Autophagy"},{"issue":"4","key":"2243_CR63","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1093\/cvr\/cvaa158","volume":"117","author":"H Enomoto","year":"2021","unstructured":"Enomoto H, Mittal N, Inomata T, Arimura T, Izumi T, Kimura A, et al. Dilated cardiomyopathy-linked heat shock protein family D member 1 mutations cause up-regulation of reactive oxygen species and autophagy through mitochondrial dysfunction. Cardiovasc Res. 2021;117(4):1118\u201331.","journal-title":"Cardiovasc Res"},{"issue":"11","key":"2243_CR64","doi-asserted-by":"publisher","DOI":"10.1111\/eci.14054","volume":"53","author":"T Svagusa","year":"2023","unstructured":"Svagusa T, Sikiric S, Milavic M, Sepac A, Seiwerth S, Milicic D, et al. Heart failure in patients is associated with downregulation of mitochondrial quality control genes. Eur J Clin Invest. 2023;53(11):e14054.","journal-title":"Eur J Clin Invest"},{"issue":"3\u20134","key":"2243_CR65","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1007\/s10495-024-02061-1","volume":"30","author":"F Tian","year":"2025","unstructured":"Tian F, He X, Wang S, Liang Y, Wang Z, Hu M, et al. Integrating single-cell sequencing and machine learning to uncover the role of mitophagy in subtyping and prognosis of esophageal cancer. Apoptosis. 2025;30(3\u20134):1021\u201341.","journal-title":"Apoptosis"},{"key":"2243_CR66","doi-asserted-by":"publisher","DOI":"10.3390\/cells11233720","author":"M Park","year":"2022","unstructured":"Park M, Shin HA, Duong VA, Lee H, Lew H. The role of extracellular vesicles in optic nerve injury: Neuroprotection and mitochondrial homeostasis. Cells. 2022. https:\/\/doi.org\/10.3390\/cells11233720.","journal-title":"Cells"},{"issue":"1","key":"2243_CR67","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-024-07326-8","volume":"7","author":"N Ghahari","year":"2024","unstructured":"Ghahari N, Shegefti S, Alaei M, Amara A, Telittchenko R, Isnard S, et al. HSP60 controls mitochondrial ATP generation for optimal virus-specific IL-21-producing CD4 and cytotoxic CD8 memory T cell responses. Commun Biol. 2024;7(1):1688.","journal-title":"Commun Biol"},{"issue":"1","key":"2243_CR68","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1161\/ATVBAHA.114.304342","volume":"35","author":"A Liu","year":"2015","unstructured":"Liu A, Ming JY, Fiskesund R, Ninio E, Karabina SA, Bergmark C, et al. Induction of dendritic cell-mediated T-cell activation by modified but not native low-density lipoprotein in humans and inhibition by annexin a5: involvement of heat shock proteins. Arterioscler Thromb Vasc Biol. 2015;35(1):197\u2013205.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"6","key":"2243_CR69","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1159\/000330786","volume":"3","author":"R Ohue","year":"2011","unstructured":"Ohue R, Hashimoto K, Nakamoto M, Furukawa Y, Masuda T, Kitabatake N, et al. Bacterial heat shock protein 60, GroEL, can induce the conversion of na\u00efve T cells into a CD4 CD25(+) Foxp3-expressing phenotype. J Innate Immun. 2011;3(6):605\u201313.","journal-title":"J Innate Immun"},{"issue":"1","key":"2243_CR70","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-79927-2","volume":"11","author":"K Shirsath","year":"2021","unstructured":"Shirsath K, Joshi A, Vohra A, Devkar R. HSP60 knockdown exerts differential response in endothelial cells and monocyte derived macrophages during atherogenic transformation. Sci Rep. 2021;11(1):1086.","journal-title":"Sci Rep"},{"key":"2243_CR71","doi-asserted-by":"publisher","DOI":"10.1038\/npjregenmed.2016.13","volume":"1","author":"W Pei","year":"2016","unstructured":"Pei W, Tanaka K, Huang SC, Xu L, Liu B, Sinclair J, et al. Extracellular HSP60 triggers tissue regeneration and wound healing by regulating inflammation and cell proliferation. npj Regen Med. 2016;1:16013-.","journal-title":"npj Regen Med"},{"key":"2243_CR72","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.bbrc.2021.06.079","volume":"569","author":"D Hu","year":"2021","unstructured":"Hu D, Liu Z, Qi X. UPR(mt) activation protects against MPP(+)-induced toxicity in a cell culture model of Parkinson\u2019s disease. Biochem Biophys Res Commun. 2021;569:17\u201322.","journal-title":"Biochem Biophys Res Commun"},{"issue":"10","key":"2243_CR73","doi-asserted-by":"publisher","first-page":"2180","DOI":"10.1007\/s11064-013-1127-8","volume":"38","author":"M Feng","year":"2013","unstructured":"Feng M, Zhang L, Liu Z, Zhou P, Lu X. The expression and release of Hsp60 in 6-OHDA induced in vivo and in vitro models of Parkinson\u2019s disease. Neurochem Res. 2013;38(10):2180\u20139.","journal-title":"Neurochem Res"},{"issue":"6","key":"2243_CR74","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1007\/s11064-015-1816-6","volume":"41","author":"C Zhao","year":"2016","unstructured":"Zhao C, Li H, Zhao X-J, Liu Z-X, Zhou P, Liu Y, et al. Heat shock protein 60 affects behavioral improvement in a rat model of Parkinson\u2019s disease grafted with human umbilical cord mesenchymal stem cell-derived dopaminergic-like neurons. Neurochem Res. 2016;41(6):1238\u201349.","journal-title":"Neurochem Res"},{"key":"2243_CR75","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21010047","author":"H Yamamoto","year":"2019","unstructured":"Yamamoto H, Fukui N, Adachi M, Saiki E, Yamasaki A, Matsumura R, et al. Human molecular chaperone Hsp60 and its apical domain suppress amyloid fibril formation of \u03b1-Synuclein. Int J Mol Sci. 2019. https:\/\/doi.org\/10.3390\/ijms21010047.","journal-title":"Int J Mol Sci"},{"issue":"3\u20134","key":"2243_CR76","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1159\/000514506","volume":"24","author":"P Chaudhuri","year":"2021","unstructured":"Chaudhuri P, Das M, Lodh I, Goswami R. Role of metabolic risk factors, family history, and genetic polymorphisms (PPAR\u03b3 and TCF7L2) on type 2 diabetes mellitus risk in an Asian Indian population. Public Health Genomics. 2021;24(3\u20134):131\u20138.","journal-title":"Public Health Genomics"},{"issue":"6","key":"2243_CR77","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1080\/15548627.2021.1975914","volume":"18","author":"T Zhang","year":"2022","unstructured":"Zhang T, Liu Q, Gao W, Sehgal SA, Wu H. The multifaceted regulation of mitophagy by endogenous metabolites. Autophagy. 2022;18(6):1216\u201339.","journal-title":"Autophagy"},{"key":"2243_CR78","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24054696","author":"X Han","year":"2023","unstructured":"Han X, Wang J, Li R, Huang M, Yue G, Guan L, et al. Placental mesenchymal stem cells alleviate podocyte injury in diabetic kidney disease by modulating mitophagy via the SIRT1-PGC-1alpha-TFAM pathway. Int J Mol Sci. 2023. https:\/\/doi.org\/10.3390\/ijms24054696.","journal-title":"Int J Mol Sci"},{"issue":"1","key":"2243_CR79","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s40001-025-02280-5","volume":"30","author":"Y Rui","year":"2025","unstructured":"Rui Y, Guo Y, He L, Wang ME, Wu H. SIRT1\/PGC-1\u03b1-mediated mitophagy participates the improvement roles of BMAL1 in podocytes injury in diabetic nephropathy: evidences from in vitro experiments. Eur J Med Res. 2025;30(1):29.","journal-title":"Eur J Med Res"},{"issue":"3","key":"2243_CR80","doi-asserted-by":"publisher","DOI":"10.1111\/cns.70346","volume":"31","author":"Y Wang","year":"2025","unstructured":"Wang Y, Ge Y, Hua S, Shen C, Cai B, Zhao H. Aloe-Emodin improves mitophagy in Alzheimer\u2019s Disease via activating the AMPK\/PGC-1\u03b1\/SIRT3 signaling pathway. CNS Neurosci Ther. 2025;31(3):e70346.","journal-title":"CNS Neurosci Ther"},{"key":"2243_CR81","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2024.177091","volume":"985","author":"Y Liu","year":"2024","unstructured":"Liu Y, Jin X, Li C, Bu J, Wang B, Bai M, et al. Baicalin attenuates corticosterone-induced hippocampal neuronal injury by activating mitophagy in an AMPK-dependent manner. Eur J Pharmacol. 2024;985:177091.","journal-title":"Eur J Pharmacol"},{"issue":"8","key":"2243_CR82","doi-asserted-by":"publisher","first-page":"4952","DOI":"10.1074\/jbc.M113.512566","volume":"289","author":"T Neill","year":"2014","unstructured":"Neill T, Torres A, Buraschi S, Owens RT, Hoek JB, Baffa R, et al. Decorin induces mitophagy in breast carcinoma cells via peroxisome proliferator-activated receptor \u03b3 coactivator-1\u03b1 (PGC-1\u03b1) and mitostatin. J Biol Chem. 2014;289(8):4952\u201368.","journal-title":"J Biol Chem"},{"issue":"6","key":"2243_CR83","doi-asserted-by":"publisher","first-page":"2315","DOI":"10.1096\/fj.14-268409","volume":"29","author":"UH Beier","year":"2015","unstructured":"Beier UH, Angelin A, Akimova T, Wang L, Liu Y, Xiao H, et al. Essential role of mitochondrial energy metabolism in Foxp3\u207a T-regulatory cell function and allograft survival. FASEB J. 2015;29(6):2315\u201326.","journal-title":"FASEB J"},{"key":"2243_CR84","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2025.104985","volume":"414","author":"LEA Damasceno","year":"2025","unstructured":"Damasceno LEA, Barbosa GAC, Sparwasser T, Cunha TM, Cunha FQ, Alves-Filho JC. PGC1\u03b1-mediated mitochondrial fitness promotes T(reg) cell differentiation. Cell Immunol. 2025;414:104985.","journal-title":"Cell Immunol"},{"issue":"10","key":"2243_CR85","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.1158\/2326-6066.CIR-23-0092","volume":"11","author":"X Zhong","year":"2023","unstructured":"Zhong X, Wu H, Ouyang C, Zhang W, Shi Y, Wang YC, et al. Ncoa2 promotes CD8+ T cell-mediated antitumor immunity by stimulating T-cell activation via upregulation of PGC-1\u03b1 critical for mitochondrial function. Cancer Immunol Res. 2023;11(10):1414\u201331.","journal-title":"Cancer Immunol Res"},{"issue":"2","key":"2243_CR86","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.immuni.2016.07.009","volume":"45","author":"NE Scharping","year":"2016","unstructured":"Scharping NE, Menk AV, Moreci RS, Whetstone RD, Dadey RE, Watkins SC, et al. The tumor microenvironment represses T cell mitochondrial biogenesis to drive intratumoral T cell metabolic insufficiency and dysfunction. Immunity. 2016;45(2):374\u201388.","journal-title":"Immunity"},{"issue":"7","key":"2243_CR87","doi-asserted-by":"publisher","first-page":"2652","DOI":"10.1111\/cas.14930","volume":"112","author":"X Hu","year":"2021","unstructured":"Hu X, Que W, Hirano H, Wang Z, Nozawa N, Ishii T, et al. 5-Aminolevulinic acid\/sodium ferrous citrate enhanced the antitumor effects of programmed cell death-ligand 1 blockade by regulation of exhausted T cell metabolism in a melanoma model. Cancer Sci. 2021;112(7):2652\u201363.","journal-title":"Cancer Sci"},{"issue":"2","key":"2243_CR88","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1016\/j.immuni.2016.07.008","volume":"45","author":"B Bengsch","year":"2016","unstructured":"Bengsch B, Johnson AL, Kurachi M, Odorizzi PM, Pauken KE, Attanasio J, et al. Bioenergetic insufficiencies due to metabolic alterations regulated by the inhibitory receptor PD-1 are an early driver of CD8(+) T cell exhaustion. Immunity. 2016;45(2):358\u201373.","journal-title":"Immunity"},{"issue":"11","key":"2243_CR89","doi-asserted-by":"publisher","first-page":"5083","DOI":"10.1172\/JCI120245","volume":"128","author":"SA Younes","year":"2018","unstructured":"Younes SA, Talla A, Pereira Ribeiro S, Saidakova EV, Korolevskaya LB, Shmagel KV, et al. Cycling CD4+ T cells in HIV-infected immune nonresponders have mitochondrial dysfunction. J Clin Invest. 2018;128(11):5083\u201394.","journal-title":"J Clin Invest"},{"issue":"1","key":"2243_CR90","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1177\/0300891619868287","volume":"106","author":"H Wan","year":"2020","unstructured":"Wan H, Xu B, Zhu N, Ren B. PGC-1\u03b1 activator-induced fatty acid oxidation in tumor-infiltrating CTLs enhances effects of PD-1 blockade therapy in lung cancer. Tumori. 2020;106(1):55\u201363.","journal-title":"Tumori"},{"issue":"6","key":"2243_CR91","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202100339R","volume":"35","author":"JL Larson-Casey","year":"2021","unstructured":"Larson-Casey JL, Gu L, Davis D, Cai GQ, Ding Q, He C, et al. Post-translational regulation of PGC-1\u03b1 modulates fibrotic repair. Faseb J. 2021;35(6):e21675.","journal-title":"Faseb J"},{"issue":"5","key":"2243_CR92","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1161\/CIRCRESAHA.115.303829","volume":"115","author":"GC Rowe","year":"2014","unstructured":"Rowe GC, Raghuram S, Jang C, Nagy JA, Patten IS, Goyal A, et al. PGC-1\u03b1 induces SPP1 to activate macrophages and orchestrate functional angiogenesis in skeletal muscle. Circ Res. 2014;115(5):504\u201317.","journal-title":"Circ Res"},{"issue":"3","key":"2243_CR93","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2021.101058","volume":"297","author":"X Zhang","year":"2021","unstructured":"Zhang X, Li X, Jia H, An G, Ni J. The m(6)A methyltransferase METTL3 modifies PGC-1\u03b1 mRNA promoting mitochondrial dysfunction and oxLDL-induced inflammation in monocytes. J Biol Chem. 2021;297(3):101058.","journal-title":"J Biol Chem"},{"key":"2243_CR94","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.exger.2018.05.014","volume":"110","author":"D Miranda","year":"2018","unstructured":"Miranda D, Jara C, Mejias S, Ahumada V, Cortez-San Martin M, Iba\u00f1ez J, et al. Deficient mitochondrial biogenesis in IL-2 activated NK cells correlates with impaired PGC1-\u03b1 upregulation in elderly humans. Exp Gerontol. 2018;110:73\u20138.","journal-title":"Exp Gerontol"},{"key":"2243_CR95","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00387","volume":"9","author":"CH Shi","year":"2018","unstructured":"Shi CH, Cheng Y, Tang MB, Liu YT, Yang ZH, Li F, et al. Analysis of single nucleotide polymorphisms of STK32B, PPARGC1A and CTNNA3 gene with sporadic Parkinson\u2019s disease susceptibility in Chinese Han population. Front Neurol. 2018;9:387.","journal-title":"Front Neurol"},{"key":"2243_CR96","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.nbd.2018.09.016","volume":"121","author":"SM Soyal","year":"2019","unstructured":"Soyal SM, Zara G, Ferger B, Felder TK, Kwik M, Nofziger C, et al. The PPARGC1A locus and CNS-specific PGC-1\u03b1 isoforms are associated with Parkinson\u2019s disease. Neurobiol Dis. 2019;121:34\u201346.","journal-title":"Neurobiol Dis"},{"issue":"7","key":"2243_CR97","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1007\/s00018-011-0850-z","volume":"69","author":"G Mud\u00f2","year":"2012","unstructured":"Mud\u00f2 G, M\u00e4kel\u00e4 J, Di Liberto V, Tselykh TV, Olivieri M, Piepponen P, et al. Transgenic expression and activation of PGC-1\u03b1 protect dopaminergic neurons in the MPTP mouse model of Parkinson\u2019s disease. Cell Mol Life Sci. 2012;69(7):1153\u201365.","journal-title":"Cell Mol Life Sci"},{"issue":"4","key":"2243_CR98","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1016\/j.freeradbiomed.2012.05.024","volume":"53","author":"A Siddiqui","year":"2012","unstructured":"Siddiqui A, Chinta SJ, Mallajosyula JK, Rajagopolan S, Hanson I, Rane A, et al. Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: implications for Parkinson\u2019s disease. Free Radic Biol Med. 2012;53(4):993\u20131003.","journal-title":"Free Radic Biol Med"},{"key":"2243_CR99","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2024.115001","volume":"383","author":"Y Qi","year":"2025","unstructured":"Qi Y, Dong Y, Chen J, Xie S, Ma X, Yu X, et al. Lactiplantibacillus plantarum SG5 inhibits neuroinflammation in MPTP-induced PD mice through GLP-1\/PGC-1\u03b1 pathway. Exp Neurol. 2025;383:115001.","journal-title":"Exp Neurol"},{"key":"2243_CR100","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2025.109954","volume":"143","author":"Y Qi","year":"2025","unstructured":"Qi Y, Xie S, Chen J, Zhang C, Ma X, Yu Y, et al. Gut microbiota regulation by Lactiplantibacillus plantarum SG5 enhances mitochondrial function in Parkinson\u2019s disease mice via the GLP-1\/PGC-1\u03b1 pathway. J Nutr Biochem. 2025;143:109954.","journal-title":"J Nutr Biochem"},{"key":"2243_CR101","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-12-82","volume":"12","author":"Q Ye","year":"2012","unstructured":"Ye Q, Ye L, Xu X, Huang B, Zhang X, Zhu Y, et al. Epigallocatechin-3-gallate suppresses 1-methyl-4-phenyl-pyridine-induced oxidative stress in PC12 cells via the SIRT1\/PGC-1\u03b1 signaling pathway. BMC Complement Altern Med. 2012;12:82.","journal-title":"BMC Complement Altern Med"},{"issue":"26","key":"2243_CR102","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2200158119","volume":"119","author":"J Su","year":"2022","unstructured":"Su J, Liu D, Yang F, Zuo MQ, Li C, Dong MQ, et al. Structural basis of Tom20 and Tom22 cytosolic domains as the human TOM complex receptors. Proc Natl Acad Sci U S A. 2022;119(26):e2200158119.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"9","key":"2243_CR103","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1016\/j.tcb.2007.07.010","volume":"17","author":"MJ Baker","year":"2007","unstructured":"Baker MJ, Frazier AE, Gulbis JM, Ryan MT. Mitochondrial protein-import machinery: correlating structure with function. Trends Cell Biol. 2007;17(9):456\u201364.","journal-title":"Trends Cell Biol"},{"issue":"7","key":"2243_CR104","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.1002\/tox.23523","volume":"37","author":"Q Zhang","year":"2022","unstructured":"Zhang Q, Bian ZX, Song Y, Wang X, Zhang H, Ren Q, et al. Regulation of mitophagy through HIF-1\u03b1\/miR-140-5p\/PARKIN axis in acute kidney injury. Environ Toxicol. 2022;37(7):1759\u201367.","journal-title":"Environ Toxicol"},{"issue":"12","key":"2243_CR105","doi-asserted-by":"publisher","first-page":"4363","DOI":"10.1080\/15548627.2021.1917129","volume":"17","author":"W El Manaa","year":"2021","unstructured":"El Manaa W, Duplan E, Goiran T, Lauritzen I, Vaillant Beuchot L, Lacas-Gervais S, et al. Transcription- and phosphorylation-dependent control of a functional interplay between XBP1s and PINK1 governs mitophagy and potentially impacts Parkinson disease pathophysiology. Autophagy. 2021;17(12):4363\u201385.","journal-title":"Autophagy"},{"issue":"4","key":"2243_CR106","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1080\/15548627.2015.1034408","volume":"11","author":"Y Wang","year":"2015","unstructured":"Wang Y, Serricchio M, Jauregui M, Shanbhag R, Stoltz T, Di Paolo CT, et al. Deubiquitinating enzymes regulate PARK2-mediated mitophagy. Autophagy. 2015;11(4):595\u2013606.","journal-title":"Autophagy"},{"key":"2243_CR107","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101671","volume":"36","author":"ZJ Fu","year":"2020","unstructured":"Fu ZJ, Wang ZY, Xu L, Chen XH, Li XX, Liao WT, et al. HIF-1\u03b1-BNIP3-mediated mitophagy in tubular cells protects against renal ischemia\/reperfusion injury. Redox Biol. 2020;36:101671.","journal-title":"Redox Biol"},{"key":"2243_CR108","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2024.111942","volume":"219","author":"RM Piergiorge","year":"2024","unstructured":"Piergiorge RM, Vasconcelos ATR, Santos-Rebou\u00e7as CB. Understanding the (epi)genetic dysregulation in Parkinson\u2019s disease through an integrative brain competitive endogenous RNA network. Mech Ageing Dev. 2024;219:111942.","journal-title":"Mech Ageing Dev"},{"issue":"11","key":"2243_CR109","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1038\/s41419-018-1154-0","volume":"9","author":"S Franco-Iborra","year":"2018","unstructured":"Franco-Iborra S, Cuadros T, Parent A, Romero-Gimenez J, Vila M, Perier C. Defective mitochondrial protein import contributes to complex I-induced mitochondrial dysfunction and neurodegeneration in Parkinson\u2019s disease. Cell Death Dis. 2018;9(11):1122.","journal-title":"Cell Death Dis"},{"issue":"342","key":"2243_CR110","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaf3634","volume":"8","author":"R Di Maio","year":"2016","unstructured":"Di Maio R, Barrett PJ, Hoffman EK, Barrett CW, Zharikov A, Borah A, et al. \u03b1-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson\u2019s disease. Sci Transl Med. 2016;8(342):342ra78.","journal-title":"Sci Transl Med"},{"issue":"13","key":"2243_CR111","doi-asserted-by":"publisher","first-page":"8968","DOI":"10.1073\/pnas.132197599","volume":"99","author":"MK Lee","year":"2002","unstructured":"Lee MK, Stirling W, Xu Y, Xu X, Qui D, Mandir AS, et al. Human alpha-synuclein-harboring familial Parkinson\u2019s disease-linked Ala-53 Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice. Proc Natl Acad Sci U S A. 2002;99(13):8968\u201373.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2243_CR112","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.104538","volume":"150","author":"Y Zhang","year":"2019","unstructured":"Zhang Y, Wu Q, Zhang L, Wang Q, Yang Z, Liu J, et al. Caffeic acid reduces A53T \u03b1-synuclein by activating JNK\/Bcl-2-mediated autophagy in vitro and improves behaviour and protects dopaminergic neurons in a mouse model of Parkinson\u2019s disease. Pharmacol Res. 2019;150:104538.","journal-title":"Pharmacol Res"},{"issue":"1","key":"2243_CR113","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1111\/nan.12298","volume":"42","author":"K Del Tredici","year":"2016","unstructured":"Del Tredici K, Braak H. Review: sporadic Parkinson\u2019s disease: development and distribution of \u03b1-synuclein pathology. Neuropathol Appl Neurobiol. 2016;42(1):33\u201350.","journal-title":"Neuropathol Appl Neurobiol"},{"issue":"4","key":"2243_CR114","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1136\/jnnp.2004.046425","volume":"76","author":"AW Michell","year":"2005","unstructured":"Michell AW, Barker RA, Raha SK, Raha-Chowdhury R. A case of late onset sporadic Parkinson\u2019s disease with an A53T mutation in alpha-synuclein. J Neurol Neurosurg Psychiatry. 2005;76(4):596\u20137.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2243_CR115","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a041645","author":"K Vekrellis","year":"2024","unstructured":"Vekrellis K, Emmanouilidou E, Xilouri M, Stefanis L. \u03b1-Synuclein in Parkinson\u2019s disease: 12 years later. Cold Spring Harb Perspect Med. 2024. https:\/\/doi.org\/10.1101\/cshperspect.a041645.","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"6","key":"2243_CR116","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1007\/s00702-024-02788-w","volume":"131","author":"H Mochizuki","year":"2024","unstructured":"Mochizuki H. Pathological mechanisms and treatment of sporadic Parkinson\u2019s disease: past, present, and future. J Neural Transm (Vienna). 2024;131(6):597\u2013607.","journal-title":"J Neural Transm (Vienna)"},{"issue":"1","key":"2243_CR117","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1021\/acs.biomac.5c00967","volume":"27","author":"Y Sun","year":"2026","unstructured":"Sun Y, Cui L, Peng W, Chen R, Guan X, Liu J. Butyrate-modified hyaluronic acid ameliorates MPTP-induced Parkinson\u2019s disease via modulating PINK1\/parkin-involved mitophagy and intestinal flora. Biomacromol. 2026;27(1):134\u201349.","journal-title":"Biomacromol"},{"key":"2243_CR118","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.154866","volume":"116","author":"Z Wang","year":"2023","unstructured":"Wang Z, Cui J, Li D, Ran S, Huang J, Chen G. Morin exhibits a neuroprotective effect in MPTP-induced Parkinson\u2019s disease model via TFEB\/AMPK-mediated mitophagy. Phytomedicine. 2023;116:154866.","journal-title":"Phytomedicine"},{"issue":"9","key":"2243_CR119","doi-asserted-by":"publisher","first-page":"2178","DOI":"10.1080\/15548627.2021.2022360","volume":"18","author":"X Qin","year":"2022","unstructured":"Qin X, Wang R, Xu H, Tu L, Chen H, Li H, et al. Identification of an autoinhibitory, mitophagy-inducing peptide derived from the transmembrane domain of USP30. Autophagy. 2022;18(9):2178\u201397.","journal-title":"Autophagy"},{"issue":"3","key":"2243_CR120","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1080\/15548627.2022.2114765","volume":"19","author":"D Lv","year":"2023","unstructured":"Lv D, Yang K, Rich JN. Growth factor receptor signaling induces mitophagy through epitranscriptomic regulation. Autophagy. 2023;19(3):1034\u20135.","journal-title":"Autophagy"},{"issue":"1","key":"2243_CR121","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1161\/CIRCRESAHA.124.323698","volume":"135","author":"Y Li","year":"2024","unstructured":"Li Y, Wei X, Xiao R, Chen Y, Xiong T, Fang ZM, et al. SMYD2-methylated PPAR\u03b3 facilitates hypoxia-induced pulmonary hypertension by activating mitophagy. Circ Res. 2024;135(1):93\u2013109.","journal-title":"Circ Res"},{"issue":"4","key":"2243_CR122","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1080\/15548627.2019.1656957","volume":"16","author":"K Niu","year":"2020","unstructured":"Niu K, Fang H, Chen Z, Zhu Y, Tan Q, Wei D, et al. USP33 deubiquitinates PRKN\/parkin and antagonizes its role in mitophagy. Autophagy. 2020;16(4):724\u201334.","journal-title":"Autophagy"},{"issue":"6","key":"2243_CR123","doi-asserted-by":"publisher","first-page":"2151","DOI":"10.7150\/ijbs.92525","volume":"20","author":"H Yan","year":"2024","unstructured":"Yan H, Ju X, Huang A, Yuan J. Advancements in technology for characterizing the tumor immune microenvironment. Int J Biol Sci. 2024;20(6):2151\u201367.","journal-title":"Int J Biol Sci"},{"issue":"5","key":"2243_CR124","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1038\/nmeth.3337","volume":"12","author":"AM Newman","year":"2015","unstructured":"Newman AM, Liu CL, Green MR, Gentles AJ, Feng W, Xu Y, et al. Robust enumeration of cell subsets from tissue expression profiles. Nat Methods. 2015;12(5):453\u20137.","journal-title":"Nat Methods"},{"issue":"7269","key":"2243_CR125","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1038\/nature08460","volume":"462","author":"DA Barbie","year":"2009","unstructured":"Barbie DA, Tamayo P, Boehm JS, Kim SY, Moody SE, Dunn IF, et al. Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1. Nature. 2009;462(7269):108\u201312.","journal-title":"Nature"},{"issue":"7","key":"2243_CR126","doi-asserted-by":"publisher","first-page":"1916","DOI":"10.1080\/15548627.2022.2162798","volume":"19","author":"B Zhang","year":"2023","unstructured":"Zhang B, Xu S, Liu M, Wei Y, Wang Q, Shen W, et al. The nucleoprotein of influenza A virus inhibits the innate immune response by inducing mitophagy. Autophagy. 2023;19(7):1916\u201333.","journal-title":"Autophagy"},{"issue":"12","key":"2243_CR127","doi-asserted-by":"publisher","first-page":"2438","DOI":"10.1016\/j.cmet.2025.09.010","volume":"37","author":"P Han","year":"2025","unstructured":"Han P, Chu S, Shen J, Li L, Zhang Y, Wang S, et al. Quercetin-derived microbial metabolite DOPAC potentiates CD8(+) T cell anti-tumor immunity via NRF2-mediated mitophagy. Cell Metab. 2025;37(12):2438-2454.e8.","journal-title":"Cell Metab"},{"key":"2243_CR128","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1310376","volume":"15","author":"CW Tie","year":"2024","unstructured":"Tie CW, Zhu JQ, Yu Z, Dou LZ, Wang ML, Wang GQ, et al. Revealing molecular and cellular heterogeneity in hypopharyngeal carcinogenesis through single-cell RNA and TCR\/BCR sequencing. Front Immunol. 2024;15:1310376.","journal-title":"Front Immunol"},{"issue":"19","key":"2243_CR129","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1042\/CS20256705","volume":"139","author":"S Tian","year":"2025","unstructured":"Tian S, Zhang Y, Liu C, Zhang H, Lu Q, Zhao Y, et al. Double-edged mitophagy: balancing inflammation and resolution in lung disease. Clin Sci (Lond). 2025;139(19):1047\u201372.","journal-title":"Clin Sci (Lond)"},{"key":"2243_CR130","doi-asserted-by":"publisher","DOI":"10.3390\/life11070648","author":"AL Reid","year":"2021","unstructured":"Reid AL, Alexander MS. The interplay of mitophagy and inflammation in Duchenne Muscular Dystrophy. Life Basel. 2021. https:\/\/doi.org\/10.3390\/life11070648.","journal-title":"Life Basel"},{"key":"2243_CR131","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.mito.2023.07.002","volume":"72","author":"AV Blagov","year":"2023","unstructured":"Blagov AV, Summerhill VI, Sukhorukov VN, Popov MA, Grechko AV, Orekhov AN. Type 1 diabetes mellitus: inflammation, mitophagy, and mitochondrial function. Mitochondrion. 2023;72:11\u201321.","journal-title":"Mitochondrion"},{"key":"2243_CR132","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1460286","volume":"15","author":"Y Zhu","year":"2024","unstructured":"Zhu Y, Zhang J, Deng Q, Chen X. Mitophagy-associated programmed neuronal death and neuroinflammation. Front Immunol. 2024;15:1460286.","journal-title":"Front Immunol"},{"issue":"1","key":"2243_CR133","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1007\/s00018-025-05873-9","volume":"82","author":"Z Su","year":"2025","unstructured":"Su Z, Shu H, Huang X, Ding L, Liang F, Xu Z, et al. Rhapontigenin attenuates neurodegeneration in a Parkinson\u2019s disease model by downregulating mtDNA-cGAS-STING-NF-\u03baB-mediated neuroinflammation via PINK1\/DRP1-dependent microglial mitophagy. Cell Mol Life Sci. 2025;82(1):337.","journal-title":"Cell Mol Life Sci"},{"key":"2243_CR134","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2025.113950","volume":"384","author":"Y Tian","year":"2025","unstructured":"Tian Y, Wang F, Ma J, Huang W, Zhang X, Du C, et al. Targeting ferroptosis and mitophagy with neutrophil-inspired nanozyme for Parkinson\u2019s disease therapy. J Control Release. 2025;384:113950.","journal-title":"J Control Release"}],"container-title":["Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00011-026-02243-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00011-026-02243-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00011-026-02243-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T21:02:16Z","timestamp":1776459736000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00011-026-02243-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,17]]},"references-count":134,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2243"],"URL":"https:\/\/doi.org\/10.1007\/s00011-026-02243-4","relation":{},"ISSN":["1420-908X"],"issn-type":[{"value":"1420-908X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,17]]},"assertion":[{"value":"28 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 March 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 March 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 April 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The Ethics Committee of the First Affiliated Hospital of Chongqing Medical University approved all animal experiments in this study in compliance with the National Animal Protection and Use Guidelines. Human ethics approval was not required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"95"}}