{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T20:20:49Z","timestamp":1788466849658,"version":"build-2803163510"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R35GM118337 and R01HL076179"],"award-info":[{"award-number":["R35GM118337 and R01HL076179"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflamm. Res."],"DOI":"10.1007\/s00011-026-02315-5","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T07:52:12Z","timestamp":1788421932000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Role of DLL4 in Neutrophil Aging and Impaired Clearance in Sepsis"],"prefix":"10.1007","volume":"75","author":[{"given":"Hui","family":"Jin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saoirse","family":"Holland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alok","family":"Jha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8195-4505","authenticated-orcid":false,"given":"Monowar","family":"Aziz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1557-0394","authenticated-orcid":false,"given":"Ping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"issue":"8","key":"2315_CR1","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1001\/jama.2016.0287","volume":"315","author":"M Singer","year":"2016","unstructured":"Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016;315(8):801\u201310.","journal-title":"JAMA"},{"key":"2315_CR2","doi-asserted-by":"publisher","first-page":"2536","DOI":"10.3389\/fimmu.2019.02536","volume":"10","author":"NL Denning","year":"2019","unstructured":"Denning NL, Aziz M, Gurien SD, Wang P. DAMPs and NETs in sepsis. Front Immunol. 2019;10:2536.","journal-title":"Front Immunol"},{"issue":"1","key":"2315_CR3","doi-asserted-by":"publisher","first-page":"e1170","DOI":"10.1002\/ctm2.1170","volume":"13","author":"H Zhang","year":"2023","unstructured":"Zhang H, Wang Y, Qu M, Li W, Wu D, Cata JP, et al. Neutrophil, neutrophil extracellular traps and endothelial cell dysfunction in sepsis. Clin Transl Med. 2023;13(1):e1170.","journal-title":"Clin Transl Med"},{"issue":"2","key":"2315_CR4","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.ccc.2023.12.003","volume":"40","author":"P Yang","year":"2024","unstructured":"Yang P, Sjoding MW. Acute respiratory distress syndrome: definition, diagnosis, and routine management. Crit Care Clin. 2024;40(2):309\u201327.","journal-title":"Crit Care Clin"},{"key":"2315_CR5","doi-asserted-by":"crossref","unstructured":"Verma N, Hochhegger B, Mukhopadhyay S, Teixeira ESTPP, Mohammed TL. Acute lung injury. J Thorac Imaging 2025;40(3).","DOI":"10.1097\/RTI.0000000000000820"},{"issue":"6","key":"2315_CR6","doi-asserted-by":"publisher","first-page":"e20220011","DOI":"10.1084\/jem.20220011","volume":"219","author":"DF Quail","year":"2022","unstructured":"Quail DF, Amulic B, Aziz M, Barnes BJ, Eruslanov E, Fridlender ZG, et al. Neutrophil phenotypes and functions in cancer: a consensus statement. J Exp Med. 2022;219(6):e20220011.","journal-title":"J Exp Med"},{"key":"2315_CR7","doi-asserted-by":"publisher","first-page":"1347453","DOI":"10.3389\/fimmu.2024.1347453","volume":"15","author":"A Murao","year":"2024","unstructured":"Murao A, Jha A, Aziz M, Wang P. Transcriptomic profiling of immune cells in murine polymicrobial sepsis. Front Immunol. 2024;15:1347453.","journal-title":"Front Immunol"},{"issue":"1","key":"2315_CR8","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1002\/JLB.3MIR1118-443R","volume":"106","author":"M Aziz","year":"2019","unstructured":"Aziz M, Brenner M, Wang P. Extracellular CIRP (eCIRP) and inflammation. J Leukoc Biol. 2019;106(1):133\u201346.","journal-title":"J Leukoc Biol"},{"issue":"11","key":"2315_CR9","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1038\/nm.3368","volume":"19","author":"X Qiang","year":"2013","unstructured":"Qiang X, Yang WL, Wu R, Zhou M, Jacob A, Dong W, et al. Cold-inducible RNA-binding protein (CIRP) triggers inflammatory responses in hemorrhagic shock and sepsis. Nat Med. 2013;19(11):1489\u201395.","journal-title":"Nat Med"},{"key":"2315_CR10","doi-asserted-by":"publisher","first-page":"791648","DOI":"10.3389\/fphar.2021.791648","volume":"12","author":"A Murao","year":"2021","unstructured":"Murao A, Tan C, Jha A, Wang P. Exosome-mediated eCIRP release from macrophages to induce inflammation in sepsis. Front Pharmacol. 2021;12:791648.","journal-title":"Front Pharmacol"},{"issue":"9","key":"2315_CR11","doi-asserted-by":"publisher","first-page":"2184","DOI":"10.4049\/jimmunol.2101004","volume":"208","author":"C Tan","year":"2022","unstructured":"Tan C, Reilly B, Jha A, Murao A, Lee Y, Brenner M, et al. Active release of eCIRP via gasdermin D channels to induce inflammation in sepsis. J Immunol. 2022;208(9):2184\u201395.","journal-title":"J Immunol"},{"issue":"2","key":"2315_CR12","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1097\/SHK.0000000000001894","volume":"57","author":"T Borjas","year":"2022","unstructured":"Borjas T, Jacob A, Yen H, Patel V, Coppa GF, Aziz M, et al. Inhibition of the interaction of TREM-1 and eCIRP attenuates inflammation and improves survival in hepatic ischemia\/reperfusion. Shock. 2022;57(2):246\u201355.","journal-title":"Shock"},{"issue":"5","key":"2315_CR13","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.3892\/ijmm.2013.1501","volume":"32","author":"M Aziz","year":"2013","unstructured":"Aziz M, Ishihara S, Ansary MU, Sonoyama H, Tada Y, Oka A, et al. Crosstalk between TLR5 and Notch1 signaling in epithelial cells during intestinal inflammation. Int J Mol Med. 2013;32(5):1051\u201362.","journal-title":"Int J Mol Med"},{"key":"2315_CR14","doi-asserted-by":"publisher","first-page":"116892","DOI":"10.1016\/j.bcp.2025.116892","volume":"236","author":"Z Liu","year":"2025","unstructured":"Liu Z, Lei Y, Zuo J, Zhang R, Du H, Hu H, et al. Activated Notch1 promotes macrophage polarization and exacerbates sepsis-induced acute lung injury via \u03b2-catenin\/NF-\u03baB signaling. Biochem Pharmacol. 2025;236:116892.","journal-title":"Biochem Pharmacol"},{"issue":"24","key":"2315_CR15","doi-asserted-by":"publisher","first-page":"e194310","DOI":"10.1172\/JCI194310","volume":"135","author":"H Jin","year":"2025","unstructured":"Jin H, Holland S, Jha A, Ma G, Li J, Murao A, et al. DLL4\u2009+\u2009neutrophils promote Notch1-mediated endothelial PANoptosis to exacerbate acute lung injury in sepsis. J Clin Invest. 2025;135(24):e194310.","journal-title":"J Clin Invest"},{"issue":"7","key":"2315_CR16","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1038\/ni.2304","volume":"13","author":"H Xu","year":"2012","unstructured":"Xu H, Zhu J, Smith S, Foldi J, Zhao B, Chung AY, et al. Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization. Nat Immunol. 2012;13(7):642\u201350.","journal-title":"Nat Immunol"},{"key":"2315_CR17","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1016\/j.jss.2019.06.060","volume":"244","author":"H Huang","year":"2019","unstructured":"Huang H, Feng H, Zhuge D. M1 Macrophage activated by notch signal pathway contributed to ventilator-induced lung injury in chronic obstructive pulmonary disease model. J Surg Res. 2019;244:358\u201367.","journal-title":"J Surg Res"},{"key":"2315_CR18","doi-asserted-by":"publisher","first-page":"115385","DOI":"10.1016\/j.bcp.2022.115385","volume":"208","author":"V Krauth","year":"2023","unstructured":"Krauth V, Bruno F, Pace S, Jordan PM, Temml V, Preziosa Romano M, et al. Highly potent and selective 5-lipoxygenase inhibition by new, simple heteroaryl-substituted catechols for treatment of inflammation. Biochem Pharmacol. 2023;208:115385.","journal-title":"Biochem Pharmacol"},{"key":"2315_CR19","doi-asserted-by":"publisher","first-page":"111143","DOI":"10.1016\/j.intimp.2023.111143","volume":"125","author":"CM Yu","year":"2023","unstructured":"Yu CM, Wang Y, Ren SC, Liu ZL, Zhu CL, Liu Q, et al. Caffeic acid modulates activation of neutrophils and attenuates sepsis-induced organ injury by inhibiting 5-LOX\/LTB4 pathway. Int Immunopharmacol. 2023;125:111143.","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"2315_CR20","doi-asserted-by":"publisher","first-page":"2483551","DOI":"10.1080\/16078454.2025.2483551","volume":"30","author":"X Xie","year":"2025","unstructured":"Xie X, Liu Y, Yang L, Zhang Z, Li H, Zhang W, et al. Impaired LTB4-induced neutrophil chemotactic directionality in myelodysplastic neoplasms patients. Hematology. 2025;30(1):2483551.","journal-title":"Hematology"},{"key":"2315_CR21","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.bbrc.2022.02.028","volume":"599","author":"S Koutsogiannaki","year":"2022","unstructured":"Koutsogiannaki S, Okuno T, Kobayashi Y, Ogawa N, Yuki K. Isoflurane attenuates sepsis-associated lung injury. Biochem Biophys Res Commun. 2022;599:127\u201333.","journal-title":"Biochem Biophys Res Commun"},{"issue":"6","key":"2315_CR22","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1016\/j.immuni.2015.05.010","volume":"42","author":"B Colom","year":"2015","unstructured":"Colom B, Bodkin JV, Beyrau M, Woodfin A, Ody C, Rourke C, et al. Leukotriene B4-neutrophil elastase axis drives neutrophil reverse transendothelial cell migration in vivo. Immunity. 2015;42(6):1075\u201386.","journal-title":"Immunity"},{"issue":"14","key":"2315_CR23","doi-asserted-by":"publisher","first-page":"e164585","DOI":"10.1172\/JCI164585","volume":"133","author":"H Jin","year":"2023","unstructured":"Jin H, Aziz M, Murao A, Kobritz M, Shih AJ, Adelson RP, et al. Antigen-presenting aged neutrophils induce CD4\u2009+\u2009T cells to exacerbate inflammation in sepsis. J Clin Invest. 2023;133(14):e164585.","journal-title":"J Clin Invest"},{"issue":"2","key":"2315_CR24","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1097\/SHK.0000000000002019","volume":"59","author":"A Murao","year":"2023","unstructured":"Murao A, Aziz M, Wang P. Neutrophil heterogeneity in sepsis: the role of damage-associated molecular patterns. Shock. 2023;59(2):239\u201346.","journal-title":"Shock"},{"issue":"5","key":"2315_CR25","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1080\/19768354.2020.1818618","volume":"24","author":"P Leclair","year":"2020","unstructured":"Leclair P, Lim CJ. CD47 (Cluster of differentiation 47): an anti-phagocytic receptor with a multitude of signaling functions. Anim Cells Syst (Seoul). 2020;24(5):243\u201352.","journal-title":"Anim Cells Syst (Seoul)"},{"issue":"1","key":"2315_CR26","doi-asserted-by":"publisher","first-page":"4564","DOI":"10.1038\/s41467-025-59621-5","volume":"16","author":"P Dai","year":"2025","unstructured":"Dai P, Sun Y, Huang Z, Liu YT, Gao M, Liu HM, et al. USP2 inhibition unleashes CD47-restrained phagocytosis and enhances anti-tumor immunity. Nat Commun. 2025;16(1):4564.","journal-title":"Nat Commun"},{"issue":"2","key":"2315_CR27","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.cell.2009.05.046","volume":"138","author":"S Jaiswal","year":"2009","unstructured":"Jaiswal S, Jamieson CH, Pang WW, Park CY, Chao MP, Majeti R, et al. CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis. Cell. 2009;138(2):271\u201385.","journal-title":"Cell"},{"issue":"1","key":"2315_CR28","doi-asserted-by":"publisher","first-page":"3666","DOI":"10.1038\/s41467-024-47963-5","volume":"15","author":"S Moon","year":"2024","unstructured":"Moon S, Han S, Jang IH, Ryu J, Rha MS, Cho HJ, et al. Airway epithelial CD47 plays a critical role in inducing influenza virus-mediated bacterial super-infection. Nat Commun. 2024;15(1):3666.","journal-title":"Nat Commun"},{"issue":"6","key":"2315_CR29","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.1016\/j.cell.2025.01.021","volume":"188","author":"AY Hsu","year":"2025","unstructured":"Hsu AY, Huang Q, Pi X, Fu J, Raghunathan K, Ghimire L, et al. Neutrophil-derived vesicles control complement activation to facilitate inflammation resolution. Cell. 2025;188(6):1623\u2013e4126.","journal-title":"Cell"},{"issue":"1","key":"2315_CR30","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/1423-0127-18-56","volume":"18","author":"PN Tsao","year":"2011","unstructured":"Tsao PN, Wei SC, Huang MT, Lee MC, Chou HC, Chen CY, et al. Lipopolysaccharide-induced Notch signaling activation through JNK-dependent pathway regulates inflammatory response. J Biomed Sci. 2011;18(1):56.","journal-title":"J Biomed Sci"},{"issue":"5","key":"2315_CR31","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1097\/SHK.0000000000001257","volume":"51","author":"H Jin","year":"2019","unstructured":"Jin H, Aziz M, Ode Y, Wang P. CIRP induces neutrophil reverse transendothelial migration in sepsis. Shock. 2019;51(5):548\u201356.","journal-title":"Shock"},{"key":"2315_CR32","doi-asserted-by":"crossref","unstructured":"Jin H, Aziz M, Murao A, Kobritz M, Shih AJ, Adelson RP et al. Antigen-presenting aged neutrophils induce CD4\u2009+\u2009T cells to exacerbate inflammation in sepsis. J Clin Invest 2023;133(14).","DOI":"10.1172\/JCI164585"},{"issue":"6","key":"2315_CR33","doi-asserted-by":"publisher","first-page":"1918","DOI":"10.1007\/s10753-024-02014-5","volume":"47","author":"S Guo","year":"2024","unstructured":"Guo S, Fu L, Yin C, Shao W, Sun Q, Chen L, et al. ROS-induced gingival fibroblast senescence: implications in exacerbating inflammatory responses in periodontal disease. Inflammation. 2024;47(6):1918\u201335.","journal-title":"Inflammation"},{"key":"2315_CR34","doi-asserted-by":"publisher","first-page":"118190","DOI":"10.1016\/j.biopha.2025.118190","volume":"188","author":"PM Jordan","year":"2025","unstructured":"Jordan PM, Peltner LK, Bachmann V, Dahlke P, Pace S, Thost L, et al. Uncovering anti-inflammatory natural products that synergize with supplemented omega-3 PUFA for eliciting endogenous inflammation resolution signals. Biomed Pharmacother. 2025;188:118190.","journal-title":"Biomed Pharmacother"},{"key":"2315_CR35","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/j.freeradbiomed.2021.02.034","volume":"166","author":"S Xie","year":"2021","unstructured":"Xie S, Qi X, Wu Q, Wei L, Zhang M, Xing Y, et al. Inhibition of 5-lipoxygenase is associated with downregulation of the leukotriene B4 receptor 1\/ Interleukin-12p35 pathway and ameliorates sepsis-induced myocardial injury. Free Radic Biol Med. 2021;166:348\u201357.","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"2315_CR36","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1111\/imr.13196","volume":"317","author":"T Yokomizo","year":"2023","unstructured":"Yokomizo T, Shimizu T. The leukotriene B(4) receptors BLT1 and BLT2 as potential therapeutic targets. Immunol Rev. 2023;317(1):30\u201341.","journal-title":"Immunol Rev"},{"key":"2315_CR37","doi-asserted-by":"publisher","first-page":"113165","DOI":"10.1016\/j.intimp.2024.113165","volume":"142Pt B","author":"D Das","year":"2024","unstructured":"Das D, Thacker H, Priya K, Jain M, Singh S, Rai G. Complement component 5a receptor 1 and leukotriene B4 receptor 1 regulate neutrophil extracellular trap (NET) formation through Rap1a\/B-Raf\/ERK signaling pathway and their deficiency in term low birth weight newborns leads to deficient NETosis. Int Immunopharmacol. 2024;142Pt B:113165.","journal-title":"Int Immunopharmacol"},{"issue":"10","key":"2315_CR38","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1016\/j.it.2011.06.008","volume":"32","author":"CD Sadik","year":"2011","unstructured":"Sadik CD, Kim ND, Luster AD. Neutrophils cascading their way to inflammation. Trends Immunol. 2011;32(10):452\u201360.","journal-title":"Trends Immunol"},{"issue":"6","key":"2315_CR39","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1002\/JLB.3A0218-050R","volume":"104","author":"Y Hirano","year":"2018","unstructured":"Hirano Y, Ode Y, Ochani M, Wang P, Aziz M. Targeting junctional adhesion molecule-C ameliorates sepsis-induced acute lung injury by decreasing CXCR4(+) aged neutrophils. J Leukoc Biol. 2018;104(6):1159\u201371.","journal-title":"J Leukoc Biol"},{"issue":"3","key":"2315_CR40","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1097\/SHK.0000000000002512","volume":"63","author":"M M\u00f6senlechner","year":"2025","unstructured":"M\u00f6senlechner M, Schl\u00f6sser D, Braum\u00fcller S, D\u00f6rfer L, Mannes M, Kawach R, et al. Induction of early pulmonary senescence in experimental sepsis. Shock. 2025;63(3):448\u201355.","journal-title":"Shock"},{"issue":"2","key":"2315_CR41","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1038\/s41385-020-0316-4","volume":"14","author":"V Azcutia","year":"2021","unstructured":"Azcutia V, Kelm M, Luissint AC, Boerner K, Flemming S, Quiros M, et al. Neutrophil expressed CD47 regulates CD11b\/CD18-dependent neutrophil transepithelial migration in the intestine in vivo. Mucosal Immunol. 2021;14(2):331\u201341.","journal-title":"Mucosal Immunol"},{"issue":"24","key":"2315_CR42","doi-asserted-by":"publisher","first-page":"e194310","DOI":"10.1172\/JCI194310","volume":"135","author":"H Jin","year":"2025","unstructured":"Jin H, Holland S, Jha A, Ma G, Li J, Murao A, et al. DLL4\u2009+\u2009neutrophils promote Notch1-mediated endothelial PANoptosis to exacerbate acute lung injury in sepsis. J Clin Investig. 2025;135(24):e194310.","journal-title":"J Clin Investig"},{"issue":"1","key":"2315_CR43","doi-asserted-by":"publisher","first-page":"12","DOI":"10.4161\/viru.26982","volume":"5","author":"MK Angele","year":"2014","unstructured":"Angele MK, Pratschke S, Hubbard WJ, Chaudry IH. Gender differences in sepsis: cardiovascular and immunological aspects. Virulence. 2014;5(1):12\u20139.","journal-title":"Virulence"},{"issue":"2","key":"2315_CR44","first-page":"137","volume":"9","author":"Y Yokoyama","year":"2003","unstructured":"Yokoyama Y, Schwacha MG, Bland KI, Chaudry IH. Effect of estradiol administration on splanchnic perfusion after trauma-hemorrhage and sepsis. Curr Opin Crit Care. 2003;9(2):137\u201342.","journal-title":"Curr Opin Crit Care"},{"issue":"7","key":"2315_CR45","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1038\/s41423-024-01165-7","volume":"21","author":"C Tan","year":"2024","unstructured":"Tan C, Reilly B, Ma G, Murao A, Jha A, Aziz M, et al. Neutrophils disrupt B-1a cell homeostasis by targeting Siglec-G to exacerbate sepsis. Cell Mol Immunol. 2024;21(7):707\u201322.","journal-title":"Cell Mol Immunol"},{"issue":"7","key":"2315_CR46","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1016\/j.jpedsurg.2024.03.025","volume":"59","author":"CP Nofi","year":"2024","unstructured":"Nofi CP, Prince JM, Aziz M, Wang P, The novel. MFG-E8-derived oligopeptide, MOP3, improves outcomes in a preclinical murine model of neonatal sepsis. J Pediatr Surg. 2024;59(7):1282\u201390.","journal-title":"J Pediatr Surg"},{"key":"2315_CR47","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/978-1-0716-3437-0_16","volume":"2713","author":"CJ Busch","year":"2024","unstructured":"Busch CJ, Subramanian S, Linares J, Favret J, Yuda RAA, Sieweke MH, Isolation. Ex vivo expansion, and lentiviral transduction of alveolar macrophages. Methods Mol Biol. 2024;2713:231\u201351.","journal-title":"Methods Mol Biol"}],"container-title":["Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00011-026-02315-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00011-026-02315-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00011-026-02315-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T20:02:08Z","timestamp":1788465728000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00011-026-02315-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,3]]},"references-count":47,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2315"],"URL":"https:\/\/doi.org\/10.1007\/s00011-026-02315-5","relation":{},"ISSN":["1420-908X"],"issn-type":[{"value":"1420-908X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,3]]},"assertion":[{"value":"16 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"194"}}