{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T13:59:20Z","timestamp":1785506360146,"version":"3.56.0"},"reference-count":146,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100004366","name":"Tabriz University of Medical Sciences","doi-asserted-by":"crossref","award":["IR.TBZMED.VCR.REC.1404.100"],"award-info":[{"award-number":["IR.TBZMED.VCR.REC.1404.100"]}],"id":[{"id":"10.13039\/501100004366","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflamm. Res."],"DOI":"10.1007\/s00011-026-02334-2","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T11:44:12Z","timestamp":1785498252000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of gut bacterial extracellular vesicles on angiogenic potential and vascular integrity: positive and negative aspects"],"prefix":"10.1007","volume":"75","author":[{"given":"Sara Aghakhani","family":"Chegeni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banafsheh","family":"Yalameha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somayyeh","family":"Rashidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonja","family":"Javani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narjes","family":"Seddighi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hesam Saghaei","family":"Bagheri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoud","family":"Khalifezadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Golbarg","family":"Roozbahani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Molaaghaee-Rouzbahani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Rahbarghazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"issue":"1","key":"2334_CR1","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1186\/s12964-023-01414-8","volume":"22","author":"H Mobarak","year":"2024","unstructured":"Mobarak H, et al. Prokaryotic microvesicles Ortholog of eukaryotic extracellular vesicles in biomedical fields. Cell Communication Signal. 2024;22(1):80.","journal-title":"Cell Communication Signal"},{"issue":"3","key":"2334_CR2","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1093\/femsre\/fuy042","volume":"43","author":"S Gill","year":"2019","unstructured":"Gill S, Catchpole R, Forterre P. Extracellular membrane vesicles in the three domains of life and beyond. FEMS Microbiol Rev. 2019;43(3):273\u2013303.","journal-title":"FEMS Microbiol Rev"},{"key":"2334_CR3","doi-asserted-by":"publisher","first-page":"194","DOI":"10.3389\/fnins.2017.00194","volume":"11","author":"A Hartmann","year":"2017","unstructured":"Hartmann A, et al. Exosomes and the prion protein: more than one truth. Front NeuroSci. 2017;11:194.","journal-title":"Front NeuroSci"},{"issue":"3","key":"2334_CR4","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/0014-4827(59)90317-9","volume":"18","author":"K Chatterjee","year":"1959","unstructured":"Chatterjee K, Gupta ND, De M. Electron microscopic observations on the morphology of Mycobacterium leprae. Exp Cell Res. 1959;18(3):521\u20137.","journal-title":"Exp Cell Res"},{"key":"2334_CR5","doi-asserted-by":"publisher","first-page":"962216","DOI":"10.3389\/fcimb.2022.962216","volume":"12","author":"N Hosseini-Giv","year":"2022","unstructured":"Hosseini-Giv N, et al. Bacterial extracellular vesicles and their novel therapeutic applications in health and cancer. Front Cell Infect Microbiol. 2022;12:962216.","journal-title":"Front Cell Infect Microbiol"},{"issue":"6","key":"2334_CR6","doi-asserted-by":"publisher","first-page":"135","DOI":"10.3390\/membranes14060135","volume":"14","author":"N Li","year":"2024","unstructured":"Li N, et al. Efficient isolation of outer membrane vesicles (OMVs) secreted by gram-negative bacteria via a novel gradient filtration method. Membranes. 2024;14(6):135.","journal-title":"Membranes"},{"issue":"1","key":"2334_CR7","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1186\/s12964-023-01414-8","volume":"22","author":"H Mobarak","year":"2024","unstructured":"Mobarak H, et al. Prokaryotic microvesicles Ortholog of eukaryotic extracellular vesicles in biomedical fields. Cell Communication Signal. 2024;22(1):80.","journal-title":"Cell Communication Signal"},{"issue":"1","key":"2334_CR8","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s12951-024-02935-1","volume":"23","author":"J Guo","year":"2025","unstructured":"Guo J, et al. Opportunities and challenges of bacterial extracellular vesicles in regenerative medicine. J Nanobiotechnol. 2025;23(1):4.","journal-title":"J Nanobiotechnol"},{"issue":"2","key":"2334_CR9","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1038\/s41591-020-01183-8","volume":"27","author":"F Asnicar","year":"2021","unstructured":"Asnicar F, et al. Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals. Nat Med. 2021;27(2):321\u201332.","journal-title":"Nat Med"},{"issue":"6","key":"2334_CR10","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1038\/s41422-020-0332-7","volume":"30","author":"D Zheng","year":"2020","unstructured":"Zheng D, Liwinski T, Elinav E. Interaction between microbiota and immunity in health and disease. Cell Res. 2020;30(6):492\u2013506.","journal-title":"Cell Res"},{"issue":"10","key":"2334_CR11","doi-asserted-by":"publisher","first-page":"2142","DOI":"10.1093\/ibd\/izy080","volume":"24","author":"F De Filippis","year":"2018","unstructured":"De Filippis F, et al. Dietary interventions to modulate the gut microbiome\u2014how far away are we from precision medicine. Inflamm Bowel Dis. 2018;24(10):2142\u201354.","journal-title":"Inflamm Bowel Dis"},{"key":"2334_CR12","doi-asserted-by":"crossref","unstructured":"Valdes AM et al. Role of the gut microbiota in nutrition and health. BMJ, 2018. 361.","DOI":"10.1136\/bmj.k2179"},{"issue":"1","key":"2334_CR13","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s13073-016-0303-2","volume":"8","author":"CL Boulang\u00e9","year":"2016","unstructured":"Boulang\u00e9 CL, et al. Impact of the gut microbiota on inflammation, obesity, and metabolic disease. Genome Med. 2016;8(1):42.","journal-title":"Genome Med"},{"issue":"7464","key":"2334_CR14","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1038\/nature12506","volume":"500","author":"E Le Chatelier","year":"2013","unstructured":"Le Chatelier E, et al. Richness of human gut microbiome correlates with metabolic markers. Nature. 2013;500(7464):541\u20136.","journal-title":"Nature"},{"issue":"17","key":"2334_CR15","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1056\/NEJMoa1109400","volume":"368","author":"WW Tang","year":"2013","unstructured":"Tang WW, et al. Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. N Engl J Med. 2013;368(17):1575\u201384.","journal-title":"N Engl J Med"},{"issue":"7341","key":"2334_CR16","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/nature09922","volume":"472","author":"Z Wang","year":"2011","unstructured":"Wang Z, et al. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature. 2011;472(7341):57\u201363.","journal-title":"Nature"},{"issue":"6","key":"2334_CR17","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1038\/nri3837","volume":"15","author":"M Kaparakis-Liaskos","year":"2015","unstructured":"Kaparakis-Liaskos M, Ferrero RL. Immune modulation by bacterial outer membrane vesicles. Nat Rev Immunol. 2015;15(6):375\u201387.","journal-title":"Nat Rev Immunol"},{"issue":"11","key":"2334_CR18","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1111\/cmi.12655","volume":"18","author":"EJ O\u2019donoghue","year":"2016","unstructured":"O\u2019donoghue EJ, Krachler AM. Mechanisms of outer membrane vesicle entry into host cells. Cell Microbiol. 2016;18(11):1508\u201317.","journal-title":"Cell Microbiol"},{"key":"2334_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.actbio.2025.05.028","volume":"200","author":"ZS Moghaddam","year":"2025","unstructured":"Moghaddam ZS, et al. Bacterial extracellular vesicles: bridging pathogen biology and therapeutic innovation. Acta Biomater. 2025;200:1\u201320.","journal-title":"Acta Biomater"},{"issue":"3","key":"2334_CR20","doi-asserted-by":"publisher","first-page":"687","DOI":"10.3390\/molecules30030687","volume":"30","author":"MV Grahl","year":"2025","unstructured":"Grahl MV, et al. Microbial trojan horses: virulence factors as key players in neurodegenerative diseases. Molecules. 2025;30(3):687.","journal-title":"Molecules"},{"issue":"2","key":"2334_CR21","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1097\/SHK.0000000000002252","volume":"61","author":"BD Liu","year":"2024","unstructured":"Liu BD, et al. Bacterial extracellular vesicles in the regulation of inflammatory response and host-microbe interactions. Shock. 2024;61(2):175\u201388.","journal-title":"Shock"},{"key":"2334_CR22","doi-asserted-by":"publisher","first-page":"432","DOI":"10.3389\/fmicb.2020.00432","volume":"11","author":"JC Caruana","year":"2020","unstructured":"Caruana JC, Walper SA. Bacterial membrane vesicles as mediators of microbe\u2013microbe and microbe\u2013host community interactions. Front Microbiol. 2020;11:432.","journal-title":"Front Microbiol"},{"key":"2334_CR23","doi-asserted-by":"publisher","first-page":"57","DOI":"10.3389\/fmicb.2020.00057","volume":"11","author":"EJ Jones","year":"2020","unstructured":"Jones EJ, et al. The uptake, trafficking, and biodistribution of Bacteroides thetaiotaomicron generated outer membrane vesicles. Front Microbiol. 2020;11:57.","journal-title":"Front Microbiol"},{"issue":"1","key":"2334_CR24","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1186\/s13287-025-04363-w","volume":"16","author":"N Mardi","year":"2025","unstructured":"Mardi N, et al. Beneficial and challenges of exosome application in ischemic heart disease. Stem Cell Res Ther. 2025;16(1):247.","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"2334_CR25","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1186\/s12951-023-01969-1","volume":"21","author":"L Yu","year":"2023","unstructured":"Yu L, et al. Apoptotic bodies: bioactive treasure left behind by the dying cells with robust diagnostic and therapeutic application potentials. J Nanobiotechnol. 2023;21(1):218.","journal-title":"J Nanobiotechnol"},{"key":"2334_CR26","doi-asserted-by":"crossref","unstructured":"L\u00e9crivain A-L, B.M.J.B.e.B.A.-G RM, Beckmann. Bacterial RNA in extracellular vesicles: A new regulator of host-pathogen interactions? 2020. 1863(7):194519.","DOI":"10.1016\/j.bbagrm.2020.194519"},{"key":"2334_CR27","doi-asserted-by":"crossref","unstructured":"Humaira et al. Bacterial Extracellular Vesicles: Potential Therapeutic Applications, Challenges, and Future Prospects. 2024. 64(10):e2400221.","DOI":"10.1002\/jobm.202400221"},{"issue":"46","key":"2334_CR28","first-page":"6951","volume":"39","author":"A Chronopoulos","year":"2020","unstructured":"Chronopoulos A, Kalluri RJO. Emerg role bacterial Extracell vesicles cancer. 2020;39(46):6951\u201360.","journal-title":"Emerg role bacterial Extracell vesicles cancer"},{"key":"2334_CR29","doi-asserted-by":"crossref","unstructured":"Gurunathan S, J.-H.J MP, Kim. Bacterial extracellular vesicles: Emerging nanoplatforms for biomedical applications. 2023:106308.","DOI":"10.1016\/j.micpath.2023.106308"},{"issue":"1","key":"2334_CR30","first-page":"545","volume":"20","author":"D-K Deng","year":"2022","unstructured":"Deng D-K, et al. Roles Extracell vesicles periodontal Homeost their therapeutic potential. 2022;20(1):545.","journal-title":"Roles Extracell vesicles periodontal Homeost their therapeutic potential"},{"key":"2334_CR31","doi-asserted-by":"crossref","unstructured":"Luo R et al. Interactions between extracellular vesicles and microbiome in human diseases: New therapeutic opportunities. 2023. 2(2):e86.","DOI":"10.1002\/imt2.86"},{"key":"2334_CR32","doi-asserted-by":"crossref","unstructured":"Fang Y et al. Biogenesis and biological functions of extracellular vesicles in cellular and organismal communication with microbes. 2022. 13:817844.","DOI":"10.3389\/fmicb.2022.817844"},{"key":"2334_CR33","doi-asserted-by":"crossref","unstructured":"Mu\u00f1oz-Echeverri LM et al. Bacterial extracellular vesicles: biotechnological perspective for enhanced productivity. 2024. 40(6):174.","DOI":"10.1007\/s11274-024-03963-7"},{"key":"2334_CR34","doi-asserted-by":"crossref","unstructured":"Toyofuku M et al. Prophage-triggered membrane vesicle formation through peptidoglycan damage in Bacillus subtilis. 2017. 8(1): 481.","DOI":"10.1038\/s41467-017-00492-w"},{"key":"2334_CR35","doi-asserted-by":"crossref","unstructured":"Pandey S, Blache A, Achouak WJM. Insights into Bacterial Extracellular Vesicle Biogenesis, Functions, and Implications in Plant\u2013Microbe Interactions. 2024. 12(3):532.","DOI":"10.3390\/microorganisms12030532"},{"key":"2334_CR36","doi-asserted-by":"publisher","unstructured":"Briaud P, Carroll RKJI, immunity. Extracell vesicle biogenesis Funct gram-positive bacteria. 2020;88(12). https:\/\/doi.org\/10.1128\/iai.00433-20.","DOI":"10.1128\/iai.00433-20"},{"key":"2334_CR37","first-page":"962216","volume":"12","author":"N Hosseini-Giv","year":"2022","unstructured":"Hosseini-Giv N, et al. Bacterial Extracell vesicles their novel therapeutic Appl health cancer. 2022;12:962216.","journal-title":"Bacterial Extracell vesicles their novel therapeutic Appl health cancer"},{"key":"2334_CR38","doi-asserted-by":"publisher","first-page":"498","DOI":"10.3389\/fmicb.2018.00498","volume":"9","author":"M-A Ca\u00f1as","year":"2018","unstructured":"Ca\u00f1as M-A, et al. Outer membrane vesicles from probiotic and commensal Escherichia coli activate NOD1-mediated immune responses in intestinal epithelial cells. Front Microbiol. 2018;9:498.","journal-title":"Front Microbiol"},{"issue":"8","key":"2334_CR39","doi-asserted-by":"publisher","first-page":"e0160374","DOI":"10.1371\/journal.pone.0160374","volume":"11","author":"M-A Ca\u00f1as","year":"2016","unstructured":"Ca\u00f1as M-A, et al. Outer membrane vesicles from the probiotic Escherichia coli Nissle 1917 and the commensal ECOR12 enter intestinal epithelial cells via clathrin-dependent endocytosis and elicit differential effects on DNA damage. PLoS ONE. 2016;11(8):e0160374.","journal-title":"PLoS ONE"},{"issue":"2","key":"2334_CR40","doi-asserted-by":"publisher","first-page":"e1006159","DOI":"10.1371\/journal.ppat.1006159","volume":"13","author":"M Bielaszewska","year":"2017","unstructured":"Bielaszewska M, et al. Host cell interactions of outer membrane vesicle-associated virulence factors of enterohemorrhagic Escherichia coli O157: Intracellular delivery, trafficking and mechanisms of cell injury. PLoS Pathog. 2017;13(2):e1006159.","journal-title":"PLoS Pathog"},{"issue":"12","key":"2334_CR41","doi-asserted-by":"publisher","first-page":"e1003797","DOI":"10.1371\/journal.ppat.1003797","volume":"9","author":"M Bielaszewska","year":"2013","unstructured":"Bielaszewska M, et al. Enterohemorrhagic Escherichia coli hemolysin employs outer membrane vesicles to target mitochondria and cause endothelial and epithelial apoptosis. PLoS Pathog. 2013;9(12):e1003797.","journal-title":"PLoS Pathog"},{"issue":"3","key":"2334_CR42","doi-asserted-by":"publisher","first-page":"e59276","DOI":"10.1371\/journal.pone.0059276","volume":"8","author":"JH Kim","year":"2013","unstructured":"Kim JH, et al. Outer membrane vesicles derived from Escherichia coli up-regulate expression of endothelial cell adhesion molecules in vitro and in vivo. PLoS ONE. 2013;8(3):e59276.","journal-title":"PLoS ONE"},{"issue":"2","key":"2334_CR43","doi-asserted-by":"publisher","first-page":"02706","DOI":"10.1128\/mbio","volume":"12","author":"MA Engevik","year":"2021","unstructured":"Engevik MA, et al. Fusobacterium nucleatum secretes outer membrane vesicles and promotes intestinal inflammation. MBio. 2021;12(2):02706\u201320. https:\/\/doi.org\/10.1128\/mbio.","journal-title":"MBio"},{"issue":"1","key":"2334_CR44","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1186\/s12964-023-01131-2","volume":"21","author":"K Laakmann","year":"2023","unstructured":"Laakmann K, et al. Bacterial extracellular vesicles repress the vascular protective factor RNase1 in human lung endothelial cells. Cell Communication Signal. 2023;21(1):111.","journal-title":"Cell Communication Signal"},{"key":"2334_CR45","doi-asserted-by":"crossref","unstructured":"Zheng Z et al. Bioengineered probiotics derived bacterial extracellular vesicle as bioactive nanocarrier for the local VEGF expression to accelerate wound healing. J Nanobiotechnol, 2026.","DOI":"10.21203\/rs.3.rs-8711594\/v1"},{"issue":"9","key":"2334_CR46","doi-asserted-by":"publisher","first-page":"4662","DOI":"10.62347\/CSJL6508","volume":"16","author":"D Cui","year":"2024","unstructured":"Cui D, et al. Disturbance of gut microbiota aggravates the inflammatory response and damages the vascular endothelial function in patients with preeclampsia. Am J Translational Res. 2024;16(9):4662.","journal-title":"Am J Translational Res"},{"key":"2334_CR47","doi-asserted-by":"crossref","unstructured":"Widom LP et al. Antibiotic treatment modulates Escherichia coli-derived bacterial extracellular vesicle (BEV) production and their capacity to upregulate ICAM-1 in human endothelial cells. bioRxiv, 2025.","DOI":"10.1101\/2025.05.12.653517"},{"issue":"1","key":"2334_CR48","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s12964-024-02002-0","volume":"23","author":"X Li","year":"2025","unstructured":"Li X, et al. Klebsiella pneumoniae-derived extracellular vesicles impair endothelial function by inhibiting SIRT1. Cell Communication Signal. 2025;23(1):21.","journal-title":"Cell Communication Signal"},{"issue":"4","key":"2334_CR49","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1159\/000519737","volume":"14","author":"L-T Song","year":"2022","unstructured":"Song L-T, et al. Porphyromonas gingivalis gingipains-mediated degradation of plasminogen activator inhibitor-1 leads to delayed wound healing responses in human endothelial cells. J Innate Immun. 2022;14(4):306\u201319.","journal-title":"J Innate Immun"},{"issue":"1","key":"2334_CR50","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1186\/s12964-024-01910-5","volume":"22","author":"SB Shaikh","year":"2024","unstructured":"Shaikh SB, et al. A signaling pathway map of plasminogen activator inhibitor-1 (PAI-1\/SERPINE-1): a review of an innovative frontier in molecular aging and cellular senescence. Cell Communication Signal. 2024;22(1):544.","journal-title":"Cell Communication Signal"},{"key":"2334_CR51","doi-asserted-by":"publisher","first-page":"497","DOI":"10.3389\/fphar.2016.00497","volume":"7","author":"I Indrakusuma","year":"2017","unstructured":"Indrakusuma I, Romacho T, Eckel J. Protease-activated receptor 2 promotes pro-atherogenic effects through transactivation of the VEGF receptor 2 in human vascular smooth muscle cells. Front Pharmacol. 2017;7:497.","journal-title":"Front Pharmacol"},{"issue":"1","key":"2334_CR52","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1152\/physrev.00044.2021","volume":"103","author":"CJ Peach","year":"2023","unstructured":"Peach CJ, et al. Protease-activated receptors in health and disease. Physiol Rev. 2023;103(1):717\u201385.","journal-title":"Physiol Rev"},{"issue":"13","key":"2334_CR53","doi-asserted-by":"publisher","first-page":"1494","DOI":"10.1177\/0022034520943187","volume":"99","author":"C Farrugia","year":"2020","unstructured":"Farrugia C, Stafford G, Murdoch C. Porphyromonas gingivalis outer membrane vesicles increase vascular permeability. J Dent Res. 2020;99(13):1494\u2013501.","journal-title":"J Dent Res"},{"key":"2334_CR54","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/j.actbio.2020.03.030","volume":"108","author":"W Huang","year":"2020","unstructured":"Huang W, et al. Modified bacterial outer membrane vesicles induce autoantibodies for tumor therapy. Acta Biomater. 2020;108:300\u201312.","journal-title":"Acta Biomater"},{"issue":"8","key":"2334_CR55","doi-asserted-by":"publisher","first-page":"5461","DOI":"10.1111\/odi.14969","volume":"30","author":"Z Chen","year":"2024","unstructured":"Chen Z, et al. Porphyromonas gingivalis OMVs promoting endothelial dysfunction via the STING pathway in periodontitis. Oral Dis. 2024;30(8):5461\u201374.","journal-title":"Oral Dis"},{"key":"2334_CR56","doi-asserted-by":"publisher","first-page":"744184","DOI":"10.3389\/fimmu.2021.744184","volume":"12","author":"D Lamprinaki","year":"2021","unstructured":"Lamprinaki D, et al. Siglec-7 mediates immunomodulation by colorectal cancer-associated Fusobacterium nucleatum ssp. animalis. Front Immunol. 2021;12:744184.","journal-title":"Front Immunol"},{"issue":"6","key":"2334_CR57","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1002\/cac2.12157","volume":"41","author":"Y Yang","year":"2021","unstructured":"Yang Y, et al. Programmed death ligand-1 regulates angiogenesis and metastasis by participating in the c\u2010JUN\/VEGFR2 signaling axis in ovarian cancer. Cancer Commun. 2021;41(6):511\u201327.","journal-title":"Cancer Commun"},{"issue":"5\u20136","key":"2334_CR58","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1080\/10799893.2024.2436461","volume":"44","author":"Z Mohammadi Azad","year":"2024","unstructured":"Mohammadi Azad Z, et al. Evaluation of the effect of Helicobacter pylori-derived OMVs and released exosomes from stomach cells treated with OMVs on the expression of genes related to the TGF-\u03b2\/SMAD signaling pathway in hepatocellular carcinoma. J Recept Signal Transduction. 2024;44(5\u20136):181\u201390.","journal-title":"J Recept Signal Transduction"},{"issue":"12","key":"2334_CR59","doi-asserted-by":"publisher","first-page":"4416","DOI":"10.3390\/ijms21124416","volume":"21","author":"F Mancini","year":"2020","unstructured":"Mancini F, et al. OMV vaccines and the role of TLR agonists in immune response. Int J Mol Sci. 2020;21(12):4416.","journal-title":"Int J Mol Sci"},{"issue":"3","key":"2334_CR60","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.3390\/ijms22031005","volume":"22","author":"EL Johnston","year":"2021","unstructured":"Johnston EL, et al. Detection of bacterial membrane vesicles by NOD-like receptors. Int J Mol Sci. 2021;22(3):1005.","journal-title":"Int J Mol Sci"},{"issue":"10","key":"2334_CR61","doi-asserted-by":"publisher","first-page":"2446","DOI":"10.3390\/cancers14102446","volume":"14","author":"M Geindreau","year":"2022","unstructured":"Geindreau M, Bruchard M, Vegran F. Role of cytokines and chemokines in angiogenesis in a tumor context. Cancers. 2022;14(10):2446.","journal-title":"Cancers"},{"key":"2334_CR62","doi-asserted-by":"publisher","first-page":"352","DOI":"10.3389\/fmed.2020.00352","volume":"7","author":"A Bhagwani","year":"2020","unstructured":"Bhagwani A, Thompson AR, Farkas L. When innate immunity meets angiogenesis\u2014the role of toll-like receptors in endothelial cells and pulmonary hypertension. Front Med. 2020;7:352.","journal-title":"Front Med"},{"issue":"3","key":"2334_CR63","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1016\/j.archoralbio.2014.12.009","volume":"60","author":"Y Jia","year":"2015","unstructured":"Jia Y, et al. Rho kinase mediates Porphyromonas gingivalis outer membrane vesicle-induced suppression of endothelial nitric oxide synthase through ERK1\/2 and p38 MAPK. Arch Oral Biol. 2015;60(3):488\u201395.","journal-title":"Arch Oral Biol"},{"key":"2334_CR64","doi-asserted-by":"publisher","first-page":"804934","DOI":"10.3389\/fcvm.2021.804934","volume":"8","author":"B Miller","year":"2022","unstructured":"Miller B, Sewell-Loftin MK. Mechanoregulation of vascular endothelial growth factor receptor 2 in angiogenesis. Front Cardiovasc Med. 2022;8:804934.","journal-title":"Front Cardiovasc Med"},{"key":"2334_CR65","doi-asserted-by":"publisher","first-page":"107936","DOI":"10.1016\/j.polymertesting.2023.107936","volume":"119","author":"Z Huang","year":"2023","unstructured":"Huang Z, et al. Preparation and evaluation of a temperature-responsive methylcellulose\/polyvinyl alcohol hydrogel for stem cell encapsulation. Polym Test. 2023;119:107936.","journal-title":"Polym Test"},{"key":"2334_CR66","doi-asserted-by":"publisher","first-page":"1270158","DOI":"10.3389\/fmicb.2023.1270158","volume":"14","author":"R Meng","year":"2023","unstructured":"Meng R, et al. The potential role of gut microbiota outer membrane vesicles in colorectal cancer. Front Microbiol. 2023;14:1270158.","journal-title":"Front Microbiol"},{"key":"2334_CR67","doi-asserted-by":"publisher","first-page":"1666589","DOI":"10.3389\/fcvm.2025.1666589","volume":"12","author":"T Li","year":"2025","unstructured":"Li T, et al. Extracellular vesicles in cardiovascular diseases: pathogenic mediators, diagnostic tools, and therapeutic vectors. Front Cardiovasc Med. 2025;12:1666589.","journal-title":"Front Cardiovasc Med"},{"issue":"10","key":"2334_CR68","doi-asserted-by":"publisher","first-page":"001435","DOI":"10.1099\/jmm.0.001435","volume":"70","author":"A Hasani","year":"2021","unstructured":"Hasani A, et al. The role of Akkermansia muciniphila in obesity, diabetes and atherosclerosis. J Med Microbiol. 2021;70(10):001435.","journal-title":"J Med Microbiol"},{"issue":"12","key":"2334_CR69","doi-asserted-by":"publisher","first-page":"2483","DOI":"10.3390\/microorganisms12122483","volume":"12","author":"L Peng","year":"2024","unstructured":"Peng L, et al. Pasteurized Akkermansia muciniphila ameliorates preeclampsia in mice by enhancing gut barrier integrity, improving endothelial function, and modulating gut metabolic dysregulation. Microorganisms. 2024;12(12):2483.","journal-title":"Microorganisms"},{"issue":"5","key":"2334_CR70","doi-asserted-by":"publisher","first-page":"12328","DOI":"10.1002\/jev2.12328","volume":"12","author":"Y Chen","year":"2023","unstructured":"Chen Y, et al. Extracellular vesicles derived from Akkermansia muciniphila promote placentation and mitigate preeclampsia in a mouse model. J Extracell Vesicles. 2023;12(5):12328.","journal-title":"J Extracell Vesicles"},{"key":"2334_CR71","doi-asserted-by":"publisher","first-page":"1296061","DOI":"10.3389\/fimmu.2024.1296061","volume":"15","author":"CY Effah","year":"2024","unstructured":"Effah CY, et al. Bacteria-derived extracellular vesicles: endogenous roles, therapeutic potentials and their biomimetics for the treatment and prevention of sepsis. Front Immunol. 2024;15:1296061.","journal-title":"Front Immunol"},{"key":"2334_CR72","doi-asserted-by":"publisher","first-page":"139","DOI":"10.3389\/fcimb.2016.00139","volume":"6","author":"M-H Ho","year":"2016","unstructured":"Ho M-H, et al. Characterization of innate immune responses of human endothelial cells induced by Porphyromonas gingivalis and their derived outer membrane vesicles. Front Cell Infect Microbiol. 2016;6:139.","journal-title":"Front Cell Infect Microbiol"},{"issue":"1","key":"2334_CR73","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1186\/s12903-024-03886-7","volume":"24","author":"J Guo","year":"2024","unstructured":"Guo J, et al. Effects and mechanisms of Porphyromonas gingivalis outer membrane vesicles induced cardiovascular injury. BMC Oral Health. 2024;24(1):112.","journal-title":"BMC Oral Health"},{"key":"2334_CR74","doi-asserted-by":"publisher","first-page":"673993","DOI":"10.3389\/fcell.2021.673993","volume":"9","author":"N Wang","year":"2021","unstructured":"Wang N, et al. Role of Outer Membrane Vesicles From Helicobacter pylori in Atherosclerosis. Front Cell Dev Biol. 2021;9:673993.","journal-title":"Front Cell Dev Biol"},{"key":"2334_CR75","doi-asserted-by":"crossref","unstructured":"Fu Z-p et al. Cronobacter sakazakii induced sepsis-associated arrhythmias through its outer membrane vesicles. Iscience, 2024. 27(9).","DOI":"10.1016\/j.isci.2024.110572"},{"key":"2334_CR76","unstructured":"Rajaram MV et al. Pseudomonas aeruginosa-mediated cardiac dysfunction is driven by extracellular vesicles released during infection. bioRxiv, 2024:2024.11. 22.624948."},{"issue":"1","key":"2334_CR77","doi-asserted-by":"publisher","first-page":"17434","DOI":"10.1038\/s41598-017-16363-9","volume":"7","author":"K Svennerholm","year":"2017","unstructured":"Svennerholm K, et al. Escherichia coli outer membrane vesicles can contribute to sepsis induced cardiac dysfunction. Sci Rep. 2017;7(1):17434.","journal-title":"Sci Rep"},{"key":"2334_CR78","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.jconrel.2023.10.027","volume":"364","author":"N Ji","year":"2023","unstructured":"Ji N, et al. Engineered bacterial extracellular vesicles for central nervous system diseases. J Controlled Release. 2023;364:46\u201360.","journal-title":"J Controlled Release"},{"issue":"1","key":"2334_CR79","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1038\/s41467-020-14963-0","volume":"11","author":"M Li","year":"2020","unstructured":"Li M, et al. Chemotaxis-driven delivery of nano-pathogenoids for complete eradication of tumors post-phototherapy. Nat Commun. 2020;11(1):1126.","journal-title":"Nat Commun"},{"issue":"9","key":"2334_CR80","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1111\/imcb.12463","volume":"99","author":"BJ Wanrooy","year":"2021","unstructured":"Wanrooy BJ, Wen SW, Wong CH. Dynamic roles of neutrophils in post-stroke neuroinflammation. Immunol Cell Biol. 2021;99(9):924\u201335.","journal-title":"Immunol Cell Biol"},{"issue":"2","key":"2334_CR81","doi-asserted-by":"publisher","first-page":"227","DOI":"10.3233\/JPD-230315","volume":"14","author":"TF Koukoulis","year":"2024","unstructured":"Koukoulis TF, et al. Do Bacterial Outer Membrane Vesicles Contribute to Chronic Inflammation in Parkinson\u2019s Disease? J Parkinson\u2019s Disease. 2024;14(2):227\u201344.","journal-title":"J Parkinson\u2019s Disease"},{"key":"2334_CR82","doi-asserted-by":"crossref","unstructured":"Shagaleeva OY et al. Investigating volatile compounds in the Bacteroides secretome. Front Microbiol, 2023. Volume 14\u20132023.","DOI":"10.3389\/fmicb.2023.1164877"},{"issue":"6","key":"2334_CR83","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.3390\/microorganisms12061053","volume":"12","author":"R Zhang","year":"2024","unstructured":"Zhang R, Li X, Zhang S. The role of bacteria in central nervous system tumors: opportunities and challenges. Microorganisms. 2024;12(6):1053.","journal-title":"Microorganisms"},{"key":"2334_CR84","doi-asserted-by":"crossref","unstructured":"Li D, et al. Bacterial outer membrane vesicles in cancer: Biogenesis, pathogenesis, and clinical application. Volume 165. Biomedicine & Pharmacotherapy; 2023.115120.","DOI":"10.1016\/j.biopha.2023.115120"},{"issue":"20","key":"2334_CR85","doi-asserted-by":"publisher","first-page":"11141","DOI":"10.3390\/ijms252011141","volume":"25","author":"EA Catalan","year":"2024","unstructured":"Catalan EA, et al. Oral Pathobiont-Derived Outer Membrane Vesicles in the Oral\u2013Gut Axis. Int J Mol Sci. 2024;25(20):11141.","journal-title":"Int J Mol Sci"},{"issue":"21","key":"2334_CR86","doi-asserted-by":"publisher","first-page":"1758","DOI":"10.3390\/cells13211758","volume":"13","author":"SC Resta","year":"2024","unstructured":"Resta SC, et al. Beyond Inflammation: Role of Pyroptosis Pathway Activation by Gram-Negative Bacteria and Their Outer Membrane Vesicles (OMVs) in the Interaction with the Host Cell. Cells. 2024;13(21):1758.","journal-title":"Cells"},{"key":"2334_CR87","unstructured":"F\u00e1brega Fern\u00e1ndez MJ. Modulation of intestinal immune response by Outer Membrane Vesicles from probiotic and commensal Escherichia coli strains. 2018."},{"issue":"2","key":"2334_CR88","doi-asserted-by":"publisher","first-page":"e70135","DOI":"10.1002\/iid3.70135","volume":"13","author":"Y Qiu","year":"2025","unstructured":"Qiu Y, et al. Porphyromonas gingivalis and Its Outer Membrane Vesicles Induce Neuroinflammation in Mice Through Distinct Mechanisms. Immun Inflamm Dis. 2025;13(2):e70135.","journal-title":"Immun Inflamm Dis"},{"key":"2334_CR89","doi-asserted-by":"crossref","unstructured":"Zhu X et al. PCV2 inhibits the Wnt signalling pathway in vivo and in vitro. 2020. 247:108787.","DOI":"10.1016\/j.vetmic.2020.108787"},{"issue":"1","key":"2334_CR90","doi-asserted-by":"publisher","first-page":"343","DOI":"10.3233\/JAD-215054","volume":"86","author":"AB Pritchard","year":"2022","unstructured":"Pritchard AB, et al. An investigation into the effects of outer membrane vesicles and lipopolysaccharide of Porphyromonas gingivalis on blood-brain barrier integrity, permeability, and disruption of scaffolding proteins in a human in vitro model. J Alzheimer\u2019s Disease. 2022;86(1):343\u201364.","journal-title":"J Alzheimer\u2019s Disease"},{"key":"2334_CR91","doi-asserted-by":"publisher","first-page":"105282","DOI":"10.1016\/j.neuint.2022.105282","volume":"154","author":"S Nonaka","year":"2022","unstructured":"Nonaka S, Kadowaki T, Nakanishi H. Secreted gingipains from Porphyromonas gingivalis increase permeability in human cerebral microvascular endothelial cells through intracellular degradation of tight junction proteins. Neurochem Int. 2022;154:105282.","journal-title":"Neurochem Int"},{"issue":"11","key":"2334_CR92","doi-asserted-by":"publisher","first-page":"e1008124","DOI":"10.1371\/journal.ppat.1008124","volume":"15","author":"H Takeuchi","year":"2019","unstructured":"Takeuchi H, et al. Porphyromonas gingivalis induces penetration of lipopolysaccharide and peptidoglycan through the gingival epithelium via degradation of junctional adhesion molecule 1. PLoS Pathog. 2019;15(11):e1008124.","journal-title":"PLoS Pathog"},{"issue":"25","key":"2334_CR93","doi-asserted-by":"publisher","first-page":"2301357","DOI":"10.1002\/advs.202301357","volume":"10","author":"Y Gan","year":"2023","unstructured":"Gan Y, et al. Bacterial membrane vesicles: physiological roles, infection immunology, and applications. Adv Sci. 2023;10(25):2301357.","journal-title":"Adv Sci"},{"issue":"5","key":"2334_CR94","doi-asserted-by":"publisher","first-page":"2904","DOI":"10.3390\/ijms25052904","volume":"25","author":"G Sangiorgio","year":"2024","unstructured":"Sangiorgio G, et al. Interactions of Gram-positive bacterial membrane vesicles and hosts: updates and future directions. Int J Mol Sci. 2024;25(5):2904.","journal-title":"Int J Mol Sci"},{"key":"2334_CR95","unstructured":"Raieli S. TLR2\/1 orchestrate human plasmacytoid dendritic cells response to Gram+ bacteria. Universit\u00e9 Paris Saclay (COmUE); 2016."},{"key":"2334_CR96","doi-asserted-by":"crossref","unstructured":"Champagne-Jorgensen K et al. Biological functions of Lacticaseibacillus rhamnosus JB-1 membrane vesicles: lipoteichoic acid, immune activity, and gut epithelial endocytosis. 2021.","DOI":"10.21203\/rs.3.rs-379923\/v1"},{"key":"2334_CR97","doi-asserted-by":"publisher","first-page":"1273813","DOI":"10.3389\/fcimb.2023.1273813","volume":"13","author":"Y Xu","year":"2023","unstructured":"Xu Y, et al. An update on our understanding of Gram-positive bacterial membrane vesicles: discovery, functions, and applications. Front Cell Infect Microbiol. 2023;13:1273813.","journal-title":"Front Cell Infect Microbiol"},{"key":"2334_CR98","doi-asserted-by":"crossref","unstructured":"Sharma S, Pellett S, Morse SA. Gram-Positive Bacterial Toxins. 2023, MDPI. p. 2054.","DOI":"10.3390\/microorganisms11082054"},{"key":"2334_CR99","doi-asserted-by":"publisher","first-page":"111545","DOI":"10.1016\/j.mehy.2024.111545","volume":"195","author":"KEMP Orteza","year":"2025","unstructured":"Orteza KEMP, et al. Potential role of bacterial extracellular vesicles in the pathophysiology of systemic lupus erythematosus. Med Hypotheses. 2025;195:111545.","journal-title":"Med Hypotheses"},{"key":"2334_CR100","doi-asserted-by":"publisher","first-page":"796867","DOI":"10.3389\/fimmu.2021.796867","volume":"12","author":"J Xie","year":"2022","unstructured":"Xie J, Van Hoecke L, Vandenbroucke RE. The impact of systemic inflammation on Alzheimer\u2019s disease pathology. Front Immunol. 2022;12:796867.","journal-title":"Front Immunol"},{"issue":"16","key":"2334_CR101","doi-asserted-by":"publisher","first-page":"7080","DOI":"10.7150\/thno.75937","volume":"12","author":"X Tang","year":"2022","unstructured":"Tang X, et al. Natural cell based biomimetic cellular transformers for targeted therapy of digestive system cancer. Theranostics. 2022;12(16):7080.","journal-title":"Theranostics"},{"issue":"2","key":"2334_CR102","doi-asserted-by":"publisher","first-page":"e10623","DOI":"10.1002\/btm2.10623","volume":"9","author":"B Zeng","year":"2024","unstructured":"Zeng B, et al. Micro Trojan horses: Engineering extracellular vesicles crossing biological barriers for drug delivery. Bioeng translational Med. 2024;9(2):e10623.","journal-title":"Bioeng translational Med"},{"issue":"6","key":"2334_CR103","doi-asserted-by":"publisher","first-page":"e410","DOI":"10.1002\/mco2.410","volume":"4","author":"W Han","year":"2023","unstructured":"Han W, et al. The emerging role of exosomes in communication between the periphery and the central nervous system. MedComm. 2023;4(6):e410.","journal-title":"MedComm"},{"key":"2334_CR104","doi-asserted-by":"publisher","first-page":"104582","DOI":"10.1016\/j.neubiorev.2022.104582","volume":"135","author":"E Duarte-Silva","year":"2022","unstructured":"Duarte-Silva E, et al. Tiny in size, big in impact: Extracellular vesicles as modulators of mood, anxiety and neurodevelopmental disorders. Neurosci Biobehavioral Reviews. 2022;135:104582.","journal-title":"Neurosci Biobehavioral Reviews"},{"issue":"1","key":"2334_CR105","doi-asserted-by":"publisher","first-page":"2452229","DOI":"10.1080\/19490976.2025.2452229","volume":"17","author":"Y Lin","year":"2025","unstructured":"Lin Y, et al. Bacterial extracellular vesicles in the initiation, progression and treatment of atherosclerosis. Gut Microbes. 2025;17(1):2452229.","journal-title":"Gut Microbes"},{"key":"2334_CR106","doi-asserted-by":"publisher","first-page":"1514726","DOI":"10.3389\/fimmu.2025.1514726","volume":"16","author":"E Marquez-Paradas","year":"2025","unstructured":"Marquez-Paradas E, et al. Microbiota-derived extracellular vesicles: current knowledge, gaps, and challenges in precision nutrition. Front Immunol. 2025;16:1514726.","journal-title":"Front Immunol"},{"key":"2334_CR107","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/s12951-025-03195-3","volume":"23","author":"H Li","year":"2025","unstructured":"Li H, et al. Innovative nanoparticle-based approaches for modulating neutrophil extracellular traps in diseases: from mechanisms to therapeutics. J Nanobiotechnol. 2025;23:88.","journal-title":"J Nanobiotechnol"},{"issue":"12","key":"2334_CR108","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.3390\/life14121584","volume":"14","author":"B Velimirov","year":"2024","unstructured":"Velimirov B, Velimirov BA. Immune Responses Elicited by Outer Membrane Vesicles of Gram-Negative Bacteria: Important Players in Vaccine Development. Life. 2024;14(12):1584.","journal-title":"Life"},{"key":"2334_CR109","doi-asserted-by":"crossref","unstructured":"M\u00fcller J et al. Bacterial membrane vesicles of Pseudomonas Aeruginosa activate AMPK signaling through inhibition of mitochondrial complex III. bioRxiv, 2024: 2024.06. 17.599317.","DOI":"10.1101\/2024.06.17.599317"},{"key":"2334_CR110","doi-asserted-by":"crossref","unstructured":"Tang W et al. The impact of gut microbiota disorders on the blood\u2013brain barrier. Infection and drug resistance, 2020:3351\u20133363.","DOI":"10.2147\/IDR.S254403"},{"key":"2334_CR111","doi-asserted-by":"crossref","unstructured":"Gao S, Li X, Han B. Bacterial and bacterial derivatives-based drug delivery systems: a novel approach for treating central nervous system disorders. Expert Opinion on Drug Delivery; 2024.1\u201318.","DOI":"10.1080\/17425247.2024.2444364"},{"issue":"12","key":"2334_CR112","doi-asserted-by":"publisher","first-page":"845","DOI":"10.3390\/toxins13120845","volume":"13","author":"A Macion","year":"2021","unstructured":"Macion A, Wyszy\u0144ska A, Godlewska R. Delivery of toxins and effectors by bacterial membrane vesicles. Toxins. 2021;13(12):845.","journal-title":"Toxins"},{"key":"2334_CR113","doi-asserted-by":"publisher","first-page":"1227655","DOI":"10.3389\/fnmol.2023.1227655","volume":"16","author":"A Kaisanlahti","year":"2023","unstructured":"Kaisanlahti A, et al. Bacterial extracellular vesicles\u2013brain invaders? A systematic review. Front Mol Neurosci. 2023;16:1227655.","journal-title":"Front Mol Neurosci"},{"issue":"3","key":"2334_CR114","doi-asserted-by":"publisher","first-page":"2852","DOI":"10.3390\/ijms24032852","volume":"24","author":"R Yang","year":"2023","unstructured":"Yang R, et al. Blood\u2013brain barrier integrity damage in bacterial meningitis: the underlying link, mechanisms, and therapeutic targets. Int J Mol Sci. 2023;24(3):2852.","journal-title":"Int J Mol Sci"},{"issue":"17","key":"2334_CR115","doi-asserted-by":"publisher","first-page":"8317","DOI":"10.1039\/D3NR06565K","volume":"16","author":"S He","year":"2024","unstructured":"He S, Zhao Z. Genetically engineered cell-derived nanovesicles for cancer immunotherapy. Nanoscale. 2024;16(17):8317\u201334.","journal-title":"Nanoscale"},{"issue":"7","key":"2334_CR116","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.3390\/cells12071003","volume":"12","author":"\u00d8 Bruserud","year":"2023","unstructured":"Bruserud \u00d8, et al. The regulation of neutrophil migration in patients with sepsis: the complexity of the molecular mechanisms and their modulation in sepsis and the heterogeneity of sepsis patients. Cells. 2023;12(7):1003.","journal-title":"Cells"},{"key":"2334_CR117","doi-asserted-by":"publisher","first-page":"1593587","DOI":"10.1080\/20013078.2019.1593587","volume":"8","author":"K Hida","year":"2019","unstructured":"Hida K, et al. ISEV2019 Abstract Book. J Extracell Vesicles. 2019;8:1593587.","journal-title":"J Extracell Vesicles"},{"issue":"1","key":"2334_CR118","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/s40168-020-00868-z","volume":"8","author":"L Durant","year":"2020","unstructured":"Durant L, et al. Bacteroides thetaiotaomicron-derived outer membrane vesicles promote regulatory dendritic cell responses in health but not in inflammatory bowel disease. Microbiome. 2020;8(1):88.","journal-title":"Microbiome"},{"issue":"5","key":"2334_CR119","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1016\/j.chom.2015.04.002","volume":"17","author":"CA Hickey","year":"2015","unstructured":"Hickey CA, et al. Colitogenic Bacteroides thetaiotaomicron antigens access host immune cells in a sulfatase-dependent manner via outer membrane vesicles. Cell Host Microbe. 2015;17(5):672\u201380.","journal-title":"Cell Host Microbe"},{"key":"2334_CR120","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.jare.2023.04.002","volume":"56","author":"G Chen","year":"2024","unstructured":"Chen G, et al. Fusobacterium nucleatum outer membrane vesicles activate autophagy to promote oral cancer metastasis. J Adv Res. 2024;56:167\u201379.","journal-title":"J Adv Res"},{"issue":"2","key":"2334_CR121","doi-asserted-by":"publisher","first-page":"e450","DOI":"10.1038\/emm.2017.282","volume":"50","author":"C Chelakkot","year":"2018","unstructured":"Chelakkot C, et al. Akkermansia muciniphila-derived extracellular vesicles influence gut permeability through the regulation of tight junctions. Exp Mol Med. 2018;50(2):e450\u2013450.","journal-title":"Exp Mol Med"},{"key":"2334_CR122","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.bioactmat.2024.02.025","volume":"36","author":"T Xiao","year":"2024","unstructured":"Xiao T, et al. Tailoring therapeutics via a systematic beneficial elements comparison between photosynthetic bacteria-derived OMVs and extruded nanovesicles. Bioactive Mater. 2024;36:48\u201361.","journal-title":"Bioactive Mater"},{"issue":"3","key":"2334_CR123","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/j.cmet.2019.06.014","volume":"30","author":"J Bi","year":"2019","unstructured":"Bi J, et al. Oncogene amplification in growth factor signaling pathways renders cancers dependent on membrane lipid remodeling. Cell Metabol. 2019;30(3):525\u201338. e8.","journal-title":"Cell Metabol"},{"issue":"6","key":"2334_CR124","doi-asserted-by":"publisher","first-page":"e70074","DOI":"10.1002\/btm2.70074","volume":"10","author":"RR Zhu","year":"2025","unstructured":"Zhu RR, et al. Engineered endothelial cells targeting and dihydrotanshinone I loaded bacterial extracellular vesicles for atherosclerosis therapy. Bioeng Translational Med. 2025;10(6):e70074.","journal-title":"Bioeng Translational Med"},{"issue":"3","key":"2334_CR125","doi-asserted-by":"publisher","first-page":"3325","DOI":"10.1021\/acsnano.4c11986","volume":"19","author":"C Zhou","year":"2025","unstructured":"Zhou C, et al. Anchoring of probiotic-membrane vesicles in hydrogels facilitates wound vascularization. ACS Nano. 2025;19(3):3325\u201338.","journal-title":"ACS Nano"},{"issue":"11","key":"2334_CR126","doi-asserted-by":"publisher","first-page":"e70093","DOI":"10.1002\/jex2.70093","volume":"4","author":"P Arnold","year":"2025","unstructured":"Arnold P, et al. Two Sides of the Same Coin\u2014Mechanistic Insight, Diagnostic Application and Therapeutic Translation of Bacterial and Host-Derived Extracellular Vesicles. J Extracell Biology. 2025;4(11):e70093.","journal-title":"J Extracell Biology"},{"issue":"2","key":"2334_CR127","doi-asserted-by":"publisher","first-page":"86","DOI":"10.3390\/fermentation12020086","volume":"12","author":"F Cannizzaro","year":"2026","unstructured":"Cannizzaro F, et al. Bacterial Extracellular Vesicles in Biotechnology: Current Challenges and Strategies for Production Enhancement. Fermentation. 2026;12(2):86.","journal-title":"Fermentation"},{"issue":"2","key":"2334_CR128","doi-asserted-by":"publisher","first-page":"714","DOI":"10.20517\/evcna.2026.09","volume":"7","author":"J Chen","year":"2026","unstructured":"Chen J, et al. Engineered bacterial extracellular vesicles as next-generation precision postbiotics: strategies, challenges and prospects. Extracell Vesicles Circulating Nucleic Acids. 2026;7(2):714\u201346.","journal-title":"Extracell Vesicles Circulating Nucleic Acids"},{"issue":"5","key":"2334_CR129","doi-asserted-by":"publisher","first-page":"e1009508","DOI":"10.1371\/journal.ppat.1009508","volume":"17","author":"RA \u00d1ahui Palomino","year":"2021","unstructured":"\u00d1ahui Palomino RA, et al. Microbiota\u2013host communications: Bacterial extracellular vesicles as a common language. PLoS Pathog. 2021;17(5):e1009508.","journal-title":"PLoS Pathog"},{"issue":"1","key":"2334_CR130","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1038\/s41579-018-0112-2","volume":"17","author":"M Toyofuku","year":"2019","unstructured":"Toyofuku M, Nomura N, Eberl L. Types and origins of bacterial membrane vesicles. Nat Rev Microbiol. 2019;17(1):13\u201324.","journal-title":"Nat Rev Microbiol"},{"issue":"4","key":"2334_CR131","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1083\/jcb.201211138","volume":"200","author":"G Raposo","year":"2013","unstructured":"Raposo G, Stoorvogel W. Extracellular vesicles: exosomes, microvesicles, and friends. J Cell Biol. 2013;200(4):373\u201383.","journal-title":"J Cell Biol"},{"issue":"10","key":"2334_CR132","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1038\/nrmicro3525","volume":"13","author":"C Schwechheimer","year":"2015","unstructured":"Schwechheimer C, Kuehn MJ. Outer-membrane vesicles from Gram-negative bacteria: biogenesis and functions. Nat Rev Microbiol. 2015;13(10):605\u201319.","journal-title":"Nat Rev Microbiol"},{"key":"2334_CR133","doi-asserted-by":"crossref","unstructured":"Battistelli M, Falcieri E. Apoptotic bodies: particular extracellular vesicles involved in intercellular communication. Advances in Medical Biochemistry, Genomics, Physiology, and Pathology, 2021:473\u2013486.","DOI":"10.1201\/9781003180449-20"},{"issue":"11","key":"2334_CR134","doi-asserted-by":"publisher","first-page":"860","DOI":"10.3390\/membranes13110860","volume":"13","author":"B Marinacci","year":"2023","unstructured":"Marinacci B, et al. Latest update on outer membrane vesicles and their role in horizontal gene transfer: A mini-review. Membranes. 2023;13(11):860.","journal-title":"Membranes"},{"issue":"4","key":"2334_CR135","doi-asserted-by":"publisher","first-page":"557","DOI":"10.20517\/evcna.2023.46","volume":"4","author":"RK Singh","year":"2023","unstructured":"Singh RK, et al. Detection by super-resolution microscopy of viral proteins inside bloodborne extracellular vesicles. Extracell Vesicles Circulating Nucleic Acids. 2023;4(4):557.","journal-title":"Extracell Vesicles Circulating Nucleic Acids"},{"key":"2334_CR136","doi-asserted-by":"publisher","first-page":"835058","DOI":"10.3389\/fmicb.2022.835058","volume":"13","author":"J Chen","year":"2022","unstructured":"Chen J, et al. Inhibitors of bacterial extracellular vesicles. Front Microbiol. 2022;13:835058.","journal-title":"Front Microbiol"},{"key":"2334_CR137","doi-asserted-by":"crossref","unstructured":"Chen S et al. Lipidomic characterization of extracellular vesicles in human serum. J circulating biomarkers, 2019. 8(1).","DOI":"10.1177\/1849454419879848"},{"key":"2334_CR138","doi-asserted-by":"publisher","unstructured":"Resch U, et al. A two-component regulatory system impacts extracellular membrane-derived vesicle production in group A Streptococcus. MBio. 2016;7(6). https:\/\/doi.org\/10.1128\/mbio.02207-16.","DOI":"10.1128\/mbio.02207-16"},{"issue":"6","key":"2334_CR139","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1038\/ncb1596","volume":"9","author":"H Valadi","year":"2007","unstructured":"Valadi H, et al. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol. 2007;9(6):654\u20139.","journal-title":"Nat Cell Biol"},{"issue":"4","key":"2334_CR140","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1038\/s41423-020-0391-1","volume":"17","author":"X Zhou","year":"2020","unstructured":"Zhou X, et al. The function and clinical application of extracellular vesicles in innate immune regulation. Cell Mol Immunol. 2020;17(4):323\u201334.","journal-title":"Cell Mol Immunol"},{"issue":"1","key":"2334_CR141","doi-asserted-by":"publisher","first-page":"e12190","DOI":"10.1002\/jev2.12190","volume":"11","author":"AG Yates","year":"2022","unstructured":"Yates AG, et al. In sickness and in health: The functional role of extracellular vesicles in physiology and pathology in vivo: Part II: Pathology. J Extracell vesicles. 2022;11(1):e12190.","journal-title":"J Extracell vesicles"},{"issue":"12","key":"2334_CR142","doi-asserted-by":"publisher","first-page":"4089","DOI":"10.1128\/IAI.00161-12","volume":"80","author":"A Elmi","year":"2012","unstructured":"Elmi A, et al. Campylobacter jejuni outer membrane vesicles play an important role in bacterial interactions with human intestinal epithelial cells. Infect Immun. 2012;80(12):4089\u201398.","journal-title":"Infect Immun"},{"issue":"1","key":"2334_CR143","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1186\/s12974-023-02728-7","volume":"20","author":"E Palacios","year":"2023","unstructured":"Palacios E, et al. Helicobacter pylori outer membrane vesicles induce astrocyte reactivity through nuclear factor-\u03baappa B activation and cause neuronal damage in vivo in a murine model. J Neuroinflamm. 2023;20(1):66.","journal-title":"J Neuroinflamm"},{"key":"2334_CR144","doi-asserted-by":"publisher","unstructured":"Zingl Franz G, et al. Outer Membrane Vesicles of Vibrio cholerae Protect and Deliver Active Cholera Toxin to Host Cells via Porin-Dependent Uptake. mBio. 2021;12(3). https:\/\/doi.org\/10.1128\/mbio.00534-21.","DOI":"10.1128\/mbio.00534-21"},{"issue":"1","key":"2334_CR145","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1186\/s40168-025-02078-x","volume":"13","author":"J Xing","year":"2025","unstructured":"Xing J, et al. Faecalibacterium prausnitzii-derived outer membrane vesicles reprogram gut microbiota metabolism to alleviate Porcine Epidemic Diarrhea Virus infection. Microbiome. 2025;13(1):90.","journal-title":"Microbiome"},{"key":"2334_CR146","doi-asserted-by":"publisher","unstructured":"Qasim M, et al. Shigella Outer Membrane Vesicles as Promising Targets for Vaccination. Int J Mol Sci. 2022;23. https:\/\/doi.org\/10.3390\/ijms23020994.","DOI":"10.3390\/ijms23020994"}],"container-title":["Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00011-026-02334-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00011-026-02334-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00011-026-02334-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T13:02:51Z","timestamp":1785502971000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00011-026-02334-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,31]]},"references-count":146,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2334"],"URL":"https:\/\/doi.org\/10.1007\/s00011-026-02334-2","relation":{},"ISSN":["1420-908X"],"issn-type":[{"value":"1420-908X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,31]]},"assertion":[{"value":"5 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 July 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 July 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"No human and\/or animal samples were used in the current manuscript. This project was registered as \u201cThe possible effect of microbiota-derived extracellular vesicles in the cardiovascular system; Review study\u201d and approved by the local ethics committee of Tabriz University of Medical Sciences under an ethical code of IR.TBZMED.VCR.REC.1404.100 on 2025-06-16.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"183"}}