{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:59:18Z","timestamp":1790279958292,"version":"4.1.0"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflamm. Res."],"DOI":"10.1007\/s00011-026-02355-x","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:07:06Z","timestamp":1790276826000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multi-omics characterization of Yao syndrome identifies three pathophysiological axes and disease-specific divergence from Blau syndrome"],"prefix":"10.1007","volume":"75","author":[{"given":"Jingyuan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guishan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"key":"2355_CR1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22126360","author":"G Di Donato","year":"2021","unstructured":"Di Donato G, d\u2019Angelo DM, Breda L, Chiarelli F. Monogenic autoinflammatory diseases: state of the art and future perspectives. Int J Mol Sci. 2021. https:\/\/doi.org\/10.3390\/ijms22126360.","journal-title":"Int J Mol Sci"},{"key":"2355_CR2","doi-asserted-by":"publisher","DOI":"10.1177\/1759720X221117880","volume":"14","author":"P Efthimiou","year":"2022","unstructured":"Efthimiou P, Petryna O, Nakasato P, Kontzias A. New insights on multigenic autoinflammatory diseases. Ther Adv Musculoskelet Dis. 2022;14:1759720X221117880. https:\/\/doi.org\/10.1177\/1759720X221117880.","journal-title":"Ther Adv Musculoskelet Dis"},{"key":"2355_CR3","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1111\/imr.12902","volume":"297","author":"BC Trindade","year":"2020","unstructured":"Trindade BC, Chen GY. NOD1 and NOD2 in inflammatory and infectious diseases. Immunol Rev. 2020;297:139\u201361. https:\/\/doi.org\/10.1111\/imr.12902.","journal-title":"Immunol Rev"},{"key":"2355_CR4","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.140178","author":"JP Boyle","year":"2014","unstructured":"Boyle JP, Parkhouse R, Monie TP. Insights into the molecular basis of the NOD2 signalling pathway. Open Biol. 2014. https:\/\/doi.org\/10.1098\/rsob.140178.","journal-title":"Open Biol"},{"key":"2355_CR5","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1016\/j.immuni.2014.12.010","volume":"41","author":"R Caruso","year":"2014","unstructured":"Caruso R, Warner N, Inohara N, Nunez G. NOD1 and NOD2: signaling, host defense, and inflammatory disease. Immunity. 2014;41:898\u2013908. https:\/\/doi.org\/10.1016\/j.immuni.2014.12.010.","journal-title":"Immunity"},{"key":"2355_CR6","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s11926-026-01212-4","volume":"28","author":"D Wu","year":"2026","unstructured":"Wu D, Matsuda T, Xie D, Shen M, Dhar A, Davis JM 3rd, et al. NOD2-related multisystem inflammatory disorders and recent advances. Curr Rheumatol Rep. 2026;28:5. https:\/\/doi.org\/10.1007\/s11926-026-01212-4.","journal-title":"Curr Rheumatol Rep"},{"key":"2355_CR7","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.semarthrit.2012.12.005","volume":"43","author":"Q Yao","year":"2013","unstructured":"Yao Q. Nucleotide-binding oligomerization domain containing 2: structure, function, and diseases. Semin Arthritis Rheum. 2013;43:125\u201330. https:\/\/doi.org\/10.1016\/j.semarthrit.2012.12.005.","journal-title":"Semin Arthritis Rheum"},{"key":"2355_CR8","doi-asserted-by":"publisher","first-page":"R148","DOI":"10.1186\/ar3462","volume":"13","author":"Q Yao","year":"2011","unstructured":"Yao Q, Zhou L, Cusumano P, Bose N, Piliang M, Jayakar B, et al. A new category of autoinflammatory disease associated with NOD2 gene mutations. Arthritis Res Ther. 2011;13:R148. https:\/\/doi.org\/10.1186\/ar3462.","journal-title":"Arthritis Res Ther"},{"key":"2355_CR9","doi-asserted-by":"publisher","first-page":"1904","DOI":"10.1093\/rheumatology\/kev207","volume":"54","author":"Q Yao","year":"2015","unstructured":"Yao Q, Shen M, McDonald C, Lacbawan F, Moran R, Shen B. NOD2-associated autoinflammatory disease: a large cohort study. Rheumatology. 2015;54:1904\u201312. https:\/\/doi.org\/10.1093\/rheumatology\/kev207.","journal-title":"Rheumatology"},{"key":"2355_CR10","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/j.jaci.2025.10.028","volume":"157","author":"S Wu","year":"2025","unstructured":"Wu S, Deng Z, Uddin A, Xin B, Gorevic PD, Yao Q. Utilization of the all of us research program in a study of genetics in Yao syndrome. J Allergy Clin Immunol. 2025;157:767\u201375. https:\/\/doi.org\/10.1016\/j.jaci.2025.10.028.","journal-title":"J Allergy Clin Immunol"},{"key":"2355_CR11","doi-asserted-by":"publisher","first-page":"365 e313","DOI":"10.1016\/j.amjmed.2016.09.028","volume":"130","author":"Q Yao","year":"2017","unstructured":"Yao Q, Shen B. A systematic analysis of treatment and outcomes of NOD2-associated autoinflammatory disease. Am J Med. 2017;130:365 e313-365 e318. https:\/\/doi.org\/10.1016\/j.amjmed.2016.09.028.","journal-title":"Am J Med"},{"key":"2355_CR12","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1458118","volume":"15","author":"H Nomani","year":"2024","unstructured":"Nomani H, Wu S, Saif A, Hwang F, Metzger J, Navetta-Modrov B, et al. Comprehensive clinical phenotype, genotype and therapy in Yao syndrome. Front Immunol. 2024;15:1458118. https:\/\/doi.org\/10.3389\/fimmu.2024.1458118.","journal-title":"Front Immunol"},{"key":"2355_CR13","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1444542","volume":"15","author":"J Zhang","year":"2024","unstructured":"Zhang J, Huang X, Shen M. Expanding clinical characteristics and genotypic profiling of Yao syndrome in Chinese patients. Front Immunol. 2024;15:1444542. https:\/\/doi.org\/10.3389\/fimmu.2024.1444542.","journal-title":"Front Immunol"},{"key":"2355_CR14","doi-asserted-by":"publisher","first-page":"502","DOI":"10.31138\/mjr.261224.erh","volume":"36","author":"GE Hasbani","year":"2025","unstructured":"Hasbani GE, Davis JM. Managing Yao syndrome: a case of beneficial treatment with upadacitinib and leflunomide. Mediterr J Rheumatol. 2025;36:502\u20134. https:\/\/doi.org\/10.31138\/mjr.261224.erh.","journal-title":"Mediterr J Rheumatol"},{"key":"2355_CR15","doi-asserted-by":"publisher","DOI":"10.1002\/acr2.90024","volume":"8","author":"N Aljundi","year":"2026","unstructured":"Aljundi N, Piranavan P. Difficult-to-treat rheumatoid arthritis with concomitant Yao syndrome with response to dual-inhibitor therapy. ACR Open Rheumatol. 2026;8:e90024. https:\/\/doi.org\/10.1002\/acr2.90024.","journal-title":"ACR Open Rheumatol"},{"key":"2355_CR16","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-024-03286-w","volume":"26","author":"J Zhang","year":"2024","unstructured":"Zhang J, Luo Y, Wu B, Huang X, Zhao M, Wu N, et al. Identifying functional dysregulation of NOD2 variant Q902K in patients with Yao syndrome. Arthritis Res Ther. 2024;26:58. https:\/\/doi.org\/10.1186\/s13075-024-03286-w.","journal-title":"Arthritis Res Ther"},{"key":"2355_CR17","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1080\/08916934.2018.1442442","volume":"51","author":"C McDonald","year":"2018","unstructured":"McDonald C, Shen M, Johnson EE, Kabi A, Yao Q. Alterations in nucleotide-binding oligomerization domain-2 expression, pathway activation, and cytokine production in Yao syndrome. Autoimmunity. 2018;51:53\u201361. https:\/\/doi.org\/10.1080\/08916934.2018.1442442.","journal-title":"Autoimmunity"},{"key":"2355_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.109466","volume":"113","author":"Z Liu","year":"2022","unstructured":"Liu Z, Zhang Y, Jin T, Yi C, Ocansey DKW, Mao F. The role of NOD2 in intestinal immune response and microbiota modulation: a therapeutic target in inflammatory bowel disease. Int Immunopharmacol. 2022;113:109466. https:\/\/doi.org\/10.1016\/j.intimp.2022.109466.","journal-title":"Int Immunopharmacol"},{"key":"2355_CR19","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1093\/ecco-jcc\/jjac124","volume":"17","author":"JJ Ashton","year":"2023","unstructured":"Ashton JJ, Seaby EG, Beattie RM, Ennis S. NOD2 in Crohn\u2019s disease-unfinished business. J Crohns Colitis. 2023;17:450\u20138. https:\/\/doi.org\/10.1093\/ecco-jcc\/jjac124.","journal-title":"J Crohns Colitis"},{"issue":"2","key":"2355_CR20","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1093\/ibd\/izae075","volume":"31","author":"S Kayali","year":"2025","unstructured":"Kayali S, Fantasia S, Gaiani F, Cavallaro LG, De\u2019Angelis GL, Laghi L. NOD2 and Crohn\u2019s disease clinical practice: from epidemiology to diagnosis and therapy, rewired. Inflamm Bowel Dis. 2025;31(2):552\u201362. https:\/\/doi.org\/10.1093\/ibd\/izae075.","journal-title":"Inflamm Bowel Dis"},{"key":"2355_CR21","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2026.1793228","author":"A Dhar","year":"2026","unstructured":"Dhar A, Kitani A, Strober W. Immunological analysis of Blau syndrome, a unique autoinflammatory state. Front Immunol. 2026. https:\/\/doi.org\/10.3389\/fimmu.2026.1793228.","journal-title":"Front Immunol"},{"key":"2355_CR22","doi-asserted-by":"publisher","DOI":"10.1186\/1546-0096-12-33","volume":"12","author":"CH Wouters","year":"2014","unstructured":"Wouters CH, Maes A, Foley KP, Bertin J, Rose CD. Blau syndrome, the prototypic auto-inflammatory granulomatous disease. Pediatr Rheumatol Online J. 2014;12:33. https:\/\/doi.org\/10.1186\/1546-0096-12-33.","journal-title":"Pediatr Rheumatol Online J"},{"issue":"339\u2013349","key":"2355_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.04.013","volume":"141","author":"S Takada","year":"2018","unstructured":"Takada S, Kambe N, Kawasaki Y, Niwa A, Honda-Ozaki F, Kobayashi K, et al. Pluripotent stem cell models of Blau syndrome reveal an IFN-gamma-dependent inflammatory response in macrophages. J Allergy Clin Immunol. 2018;141(339\u2013349):e311. https:\/\/doi.org\/10.1016\/j.jaci.2017.04.013.","journal-title":"J Allergy Clin Immunol"},{"key":"2355_CR24","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1002\/humu.20080","volume":"24","author":"I Touitou","year":"2004","unstructured":"Touitou I, Lesage S, McDermott M, Cuisset L, Hoffman H, Dode C, et al. Infevers: an evolving mutation database for auto-inflammatory syndromes. Hum Mutat. 2004;24:194\u20138. https:\/\/doi.org\/10.1002\/humu.20080.","journal-title":"Hum Mutat"},{"key":"2355_CR25","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.09.032","author":"SR Brant","year":"2016","unstructured":"Brant SR, Okou DT, Simpson CL, Cutler DJ, Haritunians T, Bradfield JP, et al. Genome-wide association study identifies African-specific susceptibility loci in African Americans with inflammatory bowel disease. Gastroenterology. 2016. https:\/\/doi.org\/10.1053\/j.gastro.2016.09.032.","journal-title":"Gastroenterology"},{"key":"2355_CR26","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1046\/j.1365-2036.2003.01607.x","volume":"17","author":"RWL Leong","year":"2003","unstructured":"Leong RWL, Armuzzi A, Ahmad T, Wong ML, Tse P, Jewell DP, et al. NOD2\/CARD15 gene polymorphisms and Crohn\u2019s disease in the Chinese population. Aliment Pharmacol Ther. 2003;17:1465\u201370.","journal-title":"Aliment Pharmacol Ther"},{"key":"2355_CR27","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1038\/s42004-025-01665-1","volume":"8","author":"DY Kirsher","year":"2025","unstructured":"Kirsher DY, Chand S, Phong A, Nguyen B, Szoke BG, Ahadi S. Current landscape of plasma proteomics from technical innovations to biological insights and biomarker discovery. Commun Chem. 2025;8:279. https:\/\/doi.org\/10.1038\/s42004-025-01665-1.","journal-title":"Commun Chem"},{"key":"2355_CR28","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1186\/s12859-018-2435-4","volume":"19","author":"M Foroutan","year":"2018","unstructured":"Foroutan M, Bhuva DD, Lyu R, Horan K, Cursons J, Davis MJ. Single sample scoring of molecular phenotypes. BMC Bioinformatics. 2018;19:404. https:\/\/doi.org\/10.1186\/s12859-018-2435-4.","journal-title":"BMC Bioinformatics"},{"key":"2355_CR29","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2026.1757941","volume":"17","author":"T Li","year":"2026","unstructured":"Li T, Liu H, Lei Q, You Z. Integrative transcriptomic meta-analysis reveals conserved transcriptional signatures and predictive biomarkers for active tuberculosis: a pathway-based machine learning approach. Front Microbiol. 2026;17:1757941. https:\/\/doi.org\/10.3389\/fmicb.2026.1757941.","journal-title":"Front Microbiol"},{"key":"2355_CR30","doi-asserted-by":"publisher","first-page":"545","DOI":"10.11144\/Javeriana.upsy10-2.cdcp","volume":"10","author":"RD Ledesma","year":"2010","unstructured":"Ledesma RD, Razumiejczyk E, Macbeth G. Cliff\u00b4s delta calculator: a non-parametric effect size program for two groups of observations. Univ Psychol. 2010;10:545\u201355. https:\/\/doi.org\/10.11144\/Javeriana.upsy10-2.cdcp.","journal-title":"Univ Psychol"},{"key":"2355_CR31","doi-asserted-by":"publisher","DOI":"10.11613\/BM.2026.010101","author":"F Fiel Peres","year":"2026","unstructured":"Fiel Peres F. Effect sizes for nonparametric tests. Biochem Med. 2026. https:\/\/doi.org\/10.11613\/BM.2026.010101.","journal-title":"Biochem Med"},{"key":"2355_CR32","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1038\/s41584-024-01086-9","volume":"20","author":"TB Niewold","year":"2024","unstructured":"Niewold TB, Aksentijevich I, Gorevic PD, Gibson G, Yao Q. Genetically transitional disease: conceptual understanding and applicability to rheumatic disease. Nat Rev Rheumatol. 2024;20:301\u201310. https:\/\/doi.org\/10.1038\/s41584-024-01086-9.","journal-title":"Nat Rev Rheumatol"},{"key":"2355_CR33","doi-asserted-by":"publisher","first-page":"39800","DOI":"10.1074\/jbc.M112.410027","volume":"287","author":"K-H Lee","year":"2012","unstructured":"Lee K-H, Biswas A, Liu Y-J, Kobayashi KS. Proteasomal degradation of Nod2 protein mediates tolerance to bacterial cell wall components. J Biol Chem. 2012;287:39800\u201311. https:\/\/doi.org\/10.1074\/jbc.M112.410027.","journal-title":"J Biol Chem"},{"key":"2355_CR34","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1007\/s13402-023-00896-5","volume":"47","author":"I-H Jeong","year":"2023","unstructured":"Jeong I-H, Yun JK, Jin J-O, Hong JH, Lee JY, Lee GD, et al. E3 ligase SOCS3 regulates NOD2 expression by ubiquitin proteasome system in lung cancer progression. Cell Oncol. 2023;47:819\u201332. https:\/\/doi.org\/10.1007\/s13402-023-00896-5.","journal-title":"Cell Oncol"},{"key":"2355_CR35","doi-asserted-by":"publisher","first-page":"2199","DOI":"10.1007\/s00011-023-01809-w","volume":"72","author":"Y Zeng","year":"2023","unstructured":"Zeng Y, Ng JPL, Wang L, Xu X, Law BYK, Chen G, et al. Mutant p53R211* ameliorates inflammatory arthritis in AIA rats via inhibition of TBK1-IRF3 innate immune response. Inflamm Res. 2023;72:2199\u2013219. https:\/\/doi.org\/10.1007\/s00011-023-01809-w.","journal-title":"Inflamm Res"},{"key":"2355_CR36","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1038\/s41423-025-01310-w","volume":"22","author":"H Mao","year":"2025","unstructured":"Mao H, Zhao X, Sun S-c. NF-\u03baB in inflammation and cancer. Cell Mol Immunol. 2025;22:811\u201339. https:\/\/doi.org\/10.1038\/s41423-025-01310-w.","journal-title":"Cell Mol Immunol"},{"key":"2355_CR37","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/j.it.2022.07.004","volume":"43","author":"D Capece","year":"2022","unstructured":"Capece D, Verzella D, Flati I, Arboretto P, Cornice J, Franzoso G. NF-kappaB: blending metabolism, immunity, and inflammation. Trends Immunol. 2022;43:757\u201375. https:\/\/doi.org\/10.1016\/j.it.2022.07.004.","journal-title":"Trends Immunol"},{"key":"2355_CR38","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.cell.2023.11.044","volume":"187","author":"K Newton","year":"2024","unstructured":"Newton K, Strasser A, Kayagaki N, Dixit VM. Cell death. Cell. 2024;187:235\u201356. https:\/\/doi.org\/10.1016\/j.cell.2023.11.044.","journal-title":"Cell"},{"key":"2355_CR39","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1038\/s41586-023-05991-z","volume":"618","author":"M Degen","year":"2023","unstructured":"Degen M, Santos JC, Pluhackova K, Cebrero G, Ramos S, Jankevicius G, et al. Structural basis of NINJ1-mediated plasma membrane rupture in cell death. Nature. 2023;618:1065\u201371. https:\/\/doi.org\/10.1038\/s41586-023-05991-z.","journal-title":"Nature"},{"key":"2355_CR40","doi-asserted-by":"publisher","DOI":"10.20900\/immunometab20210025","volume":"3","author":"LA Groh","year":"2021","unstructured":"Groh LA, Ferreira AV, Helder L, van der Heijden CDCC, Novakovic B, van de Westerlo E, et al. OxLDL-induced trained immunity is dependent on mitochondrial metabolic reprogramming. Immunometabolism. 2021;3:e210025. https:\/\/doi.org\/10.20900\/immunometab20210025.","journal-title":"Immunometabolism"},{"key":"2355_CR41","doi-asserted-by":"publisher","DOI":"10.31083\/j.fbl2809210","volume":"28","author":"G Lee","year":"2023","unstructured":"Lee G, Ahn H, Lee E, Lee G-S. The role of NLRP3 inflammasomes in trained immunity. Front Biosci. 2023;28:210. https:\/\/doi.org\/10.31083\/j.fbl2809210.","journal-title":"Front Biosci"},{"key":"2355_CR42","doi-asserted-by":"publisher","first-page":"13","DOI":"10.46439\/rheumatology.5.029","volume":"5","author":"JA Damianos","year":"2025","unstructured":"Damianos JA. Yao syndrome (NOD2-associated autoinflammatory disease) and the gastrointestinal tract: future perspectives and research priorities. Curr Rheumatol Res. 2025;5:13\u20136. https:\/\/doi.org\/10.46439\/rheumatology.5.029.","journal-title":"Curr Rheumatol Res"},{"key":"2355_CR43","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1093\/rheumatology\/ket384","volume":"53","author":"Q Yao","year":"2014","unstructured":"Yao Q, Myles J, Shen B, McDonald C. NOD2-associated autoinflammatory disease: an exploratory study of its pathogenesis. Rheumatology. 2014;53:958\u201360. https:\/\/doi.org\/10.1093\/rheumatology\/ket384.","journal-title":"Rheumatology"},{"key":"2355_CR44","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-84938-8","volume":"11","author":"JE Horowitz","year":"2021","unstructured":"Horowitz JE, Warner N, Staples J, Crowley E, Gosalia N, Murchie R, et al. Mutation spectrum of NOD2 reveals recessive inheritance as a main driver of early onset Crohn\u2019s disease. Sci Rep. 2021;11:5595. https:\/\/doi.org\/10.1038\/s41598-021-84938-8.","journal-title":"Sci Rep"},{"key":"2355_CR45","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1093\/ibd\/izae075","volume":"31","author":"S Kayali","year":"2025","unstructured":"Kayali S, Fantasia S, Gaiani F, Cavallaro LG, de\u2019Angelis GL, Laghi L. NOD2 and Crohn\u2019s disease clinical practice: from epidemiology to diagnosis and therapy rewired. Inflamm Bowel Dis. 2025;31:552\u201362. https:\/\/doi.org\/10.1093\/ibd\/izae075.","journal-title":"Inflamm Bowel Dis"},{"key":"2355_CR46","doi-asserted-by":"publisher","first-page":"1304792","DOI":"10.3389\/fimmu.2024.1304792","volume":"15","author":"KA Williamson","year":"2024","unstructured":"Williamson KA, Samec MJ, Patel JA, Orandi AB, Wang B, Crowson CS, et al. Clinical phenotype, NOD2 genotypes, and treatment observations in Yao syndrome: a retrospective case series. Front Immunol. 2024;15:1304792. https:\/\/doi.org\/10.3389\/fimmu.2024.1304792.","journal-title":"Front Immunol"},{"key":"2355_CR47","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.tig.2022.11.002","volume":"39","author":"Q Yao","year":"2023","unstructured":"Yao Q, Gorevic P, Shen B, Gibson G. Genetically transitional disease: a new concept in genomic medicine. Trends Genet. 2023;39:98\u2013108. https:\/\/doi.org\/10.1016\/j.tig.2022.11.002.","journal-title":"Trends Genet"},{"key":"2355_CR48","doi-asserted-by":"publisher","first-page":"1128358","DOI":"10.3389\/fimmu.2023.1128358","volume":"14","author":"Y Li","year":"2023","unstructured":"Li Y, Jiang Q. Uncoupled pyroptosis and IL-1\u03b2 secretion downstream of inflammasome signaling. Front Immunol. 2023;14:1128358. https:\/\/doi.org\/10.3389\/fimmu.2023.1128358.","journal-title":"Front Immunol"},{"key":"2355_CR49","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1016\/j.immuni.2016.01.012","volume":"44","author":"MM Gaidt","year":"2016","unstructured":"Gaidt MM, Ebert TS, Chauhan D, Schmidt T, Schmid-Burgk JL, Rapino F, et al. Human monocytes engage an alternative inflammasome pathway. Immunity. 2016;44:833\u201346. https:\/\/doi.org\/10.1016\/j.immuni.2016.01.012.","journal-title":"Immunity"},{"key":"2355_CR50","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.11.013","author":"CL Evavold","year":"2017","unstructured":"Evavold CL, Ruan J, Tan Y, Xia S, Wu H, Kagan JC. The pore-forming protein Gasdermin D regulates interleukin-1 secretion from living macrophages. Immunity. 2017. https:\/\/doi.org\/10.1016\/j.immuni.2017.11.013.","journal-title":"Immunity"},{"key":"2355_CR51","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1016\/j.jaci.2012.02.004","volume":"129","author":"CEI Janssen","year":"2012","unstructured":"Janssen CEI, Rose CD, De Hertogh G, Martin TM, Bader Meunier B, Cimaz R, et al. Morphologic and immunohistochemical characterization of granulomas in the nucleotide oligomerization domain 2-related disorders Blau syndrome and Crohn disease. J Allergy Clin Immunol. 2012;129:1076\u201384. https:\/\/doi.org\/10.1016\/j.jaci.2012.02.004.","journal-title":"J Allergy Clin Immunol"},{"key":"2355_CR52","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01801-8","volume":"9","author":"C Zhu","year":"2024","unstructured":"Zhu C, Xu S, Jiang R, Yu Y, Bian J, Zou Z. The gasdermin family: emerging therapeutic targets in diseases. Signal Transduct Target Ther. 2024;9:87. https:\/\/doi.org\/10.1038\/s41392-024-01801-8.","journal-title":"Signal Transduct Target Ther"},{"key":"2355_CR53","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2024.103649","volume":"23","author":"C Ramakrishna","year":"2024","unstructured":"Ramakrishna C, Mason A, Edwards CJ. Tyrosine kinase 2 inhibitors in autoimmune diseases. Autoimmun Rev. 2024;23:103649. https:\/\/doi.org\/10.1016\/j.autrev.2024.103649.","journal-title":"Autoimmun Rev"},{"key":"2355_CR54","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2025.103920","volume":"24","author":"X Wang","year":"2025","unstructured":"Wang X, Luo Y, Zhou Q, Ma J. The roles of S100A8\/A9 and S100A12 in autoimmune diseases: mechanisms, biomarkers, and therapeutic potential. Autoimmun Rev. 2025;24:103920. https:\/\/doi.org\/10.1016\/j.autrev.2025.103920.","journal-title":"Autoimmun Rev"},{"key":"2355_CR55","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12040750","author":"S Srsen","year":"2024","unstructured":"Srsen S, Held M, Sestan M, Kifer N, Kozmar A, Supe Domic D, et al. Serum levels of S100A8\/A9 as a biomarker of disease activity in patients with IgA vasculitis. Biomedicines. 2024. https:\/\/doi.org\/10.3390\/biomedicines12040750.","journal-title":"Biomedicines"}],"container-title":["Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00011-026-02355-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00011-026-02355-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00011-026-02355-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:07:07Z","timestamp":1790276827000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00011-026-02355-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,24]]},"references-count":55,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2355"],"URL":"https:\/\/doi.org\/10.1007\/s00011-026-02355-x","relation":{},"ISSN":["1420-908X"],"issn-type":[{"value":"1420-908X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,24]]},"assertion":[{"value":"16 June 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 August 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 September 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Institutional Review Board of Peking Union Medical College Hospital (approval no. ZS-3272) and conducted in accordance with the Declaration of Helsinki. Written informed consent was obtained from all participants.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"223"}}