{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:46:46Z","timestamp":1792273606586,"version":"4.4.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:00:00Z","timestamp":1792195200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:00:00Z","timestamp":1792195200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the Research Fund of Health Commission of Guangdong Province","award":["A2023130"],"award-info":[{"award-number":["A2023130"]}]},{"name":"the Research Fund of Health Commission of Guangdong Province","award":["B2023141"],"award-info":[{"award-number":["B2023141"]}]},{"name":"National Natural Science Foundation of China","award":["82603511"],"award-info":[{"award-number":["82603511"]}]},{"name":"National Natural Science Foundation of China","award":["82471780"],"award-info":[{"award-number":["82471780"]}]},{"name":"the Science and Technology Fund of Guangdong Provincial Hospital of Chinese Medicine","award":["YN2024GZRPY048"],"award-info":[{"award-number":["YN2024GZRPY048"]}]},{"name":"Zhongshan's Third Batch of Social Welfare and Basic Research Projects","award":["2023B3024"],"award-info":[{"award-number":["2023B3024"]}]},{"name":"Zhongshan Scientific Research Special Project for the Inheritance and Innovative Development of Traditional Chinese Medicine","award":["2024B3008"],"award-info":[{"award-number":["2024B3008"]}]},{"name":"Fund of the State Key Laboratory of Respiratory Diseases","award":["SKLRD-Z-202506"],"award-info":[{"award-number":["SKLRD-Z-202506"]}]},{"name":"Guangdong Special Support Plan for Young Top-notch Talent Project","award":["2024TQ08A146"],"award-info":[{"award-number":["2024TQ08A146"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflamm. Res."],"DOI":"10.1007\/s00011-026-02393-5","type":"journal-article","created":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:18:49Z","timestamp":1792271929000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["TRIM36 catalyzes K63-linked ubiquitination of TAK1 to drive septic inflammation"],"prefix":"10.1007","volume":"75","author":[{"given":"Shijie","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingnai","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zulaya","family":"Abudureyimu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijin","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junli","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiru","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolong","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suwan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhao","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuling","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouhai","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7901-4410","authenticated-orcid":false,"given":"Shengfeng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,17]]},"reference":[{"key":"2393_CR1","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/S0140-6736(18)30696-2","volume":"392","author":"M Cecconi","year":"2018","unstructured":"Cecconi M, Evans L, Levy M, Rhodes A. Sepsis and septic shock. Lancet. 2018;392:75\u201387.","journal-title":"Lancet"},{"key":"2393_CR2","doi-asserted-by":"publisher","first-page":"108","DOI":"10.3389\/fcell.2019.00108","volume":"7","author":"C Nedeva","year":"2019","unstructured":"Nedeva C, Menassa J, Puthalakath H. Sepsis: inflammation is a necessary evil. Front Cell Dev Biol. 2019;7:108.","journal-title":"Front Cell Dev Biol"},{"key":"2393_CR3","doi-asserted-by":"publisher","first-page":"2179","DOI":"10.1007\/s00011-024-01957-7","volume":"73","author":"S Chen","year":"2024","unstructured":"Chen S, Zhang C, Luo J, Lin Z, Chang T, Dong L, et al. Macrophage activation syndrome in sepsis: from pathogenesis to clinical management. Inflamm Res. 2024;73:2179\u201397.","journal-title":"Inflamm Res"},{"key":"2393_CR4","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/s41577-019-0215-7","volume":"20","author":"T Gong","year":"2020","unstructured":"Gong T, Liu L, Jiang W, Zhou R. DAMP-sensing receptors in sterile inflammation and inflammatory diseases. Nat Rev Immunol. 2020;20:95\u2013112.","journal-title":"Nat Rev Immunol"},{"key":"2393_CR5","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1016\/j.cell.2020.02.041","volume":"180","author":"KA Fitzgerald","year":"2020","unstructured":"Fitzgerald KA, Kagan JC. Toll-like receptors and the control of immunity. Cell. 2020;180:1044\u201366.","journal-title":"Cell"},{"key":"2393_CR6","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/s41392-024-01757-9","volume":"9","author":"Q Guo","year":"2024","unstructured":"Guo Q, Jin Y, Chen X, Ye X, Shen X, Lin M, et al. NF-\u03baB in biology and targeted therapy: new insights and translational implications. Signal Transduct Target Ther. 2024;9:53.","journal-title":"Signal Transduct Target Ther"},{"key":"2393_CR7","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1038\/18465","volume":"398","author":"J Ninomiya-Tsuji","year":"1999","unstructured":"Ninomiya-Tsuji J, Kishimoto K, Hiyama A, Inoue J, Cao Z, Matsumoto K. The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway. Nature. 1999;398:252\u20136.","journal-title":"Nature"},{"key":"2393_CR8","doi-asserted-by":"publisher","first-page":"200099","DOI":"10.1098\/rsob.200099","volume":"10","author":"J Totzke","year":"2020","unstructured":"Totzke J, Scarneo SA, Yang KW, Haystead TAJ. TAK1: a potent tumour necrosis factor inhibitor for the treatment of inflammatory diseases. Open Biol. 2020;10:200099.","journal-title":"Open Biol"},{"key":"2393_CR9","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.tibs.2017.01.002","volume":"42","author":"S Hatakeyama","year":"2017","unstructured":"Hatakeyama S. TRIM family proteins: roles in autophagy, immunity, and carcinogenesis. Trends Biochem Sci. 2017;42:297\u2013311.","journal-title":"Trends Biochem Sci"},{"key":"2393_CR10","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1186\/1476-4598-10-129","volume":"10","author":"R Ummanni","year":"2011","unstructured":"Ummanni R, Jost E, Braig M, Lohmann F, Mundt F, Barett C, et al. Ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) is a potential tumour suppressor in prostate cancer and is frequently silenced by promoter methylation. Mol Cancer. 2011;10:129.","journal-title":"Mol Cancer"},{"key":"2393_CR11","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1152\/physrev.00012.2016","volume":"97","author":"N Foot","year":"2017","unstructured":"Foot N, Henshall T, Kumar S. Ubiquitination and the regulation of membrane proteins. Physiol Rev. 2017;97:253\u201381.","journal-title":"Physiol Rev"},{"key":"2393_CR12","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1146\/annurev-biochem-060815-014922","volume":"86","author":"N Zheng","year":"2017","unstructured":"Zheng N, Shabek N. Ubiquitin ligases: structure, function, and regulation. Annu Rev Biochem. 2017;86:129\u201357.","journal-title":"Annu Rev Biochem"},{"key":"2393_CR13","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1242\/jcs.183954","volume":"129","author":"M Akutsu","year":"2016","unstructured":"Akutsu M, Dikic I, Bremm A. Ubiquitin chain diversity at a glance. J Cell Sci. 2016;129:875\u201380.","journal-title":"J Cell Sci"},{"key":"2393_CR14","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1038\/nm.3739","volume":"20","author":"D Popovic","year":"2014","unstructured":"Popovic D, Vucic D, Dikic I. Ubiquitination in disease pathogenesis and treatment. Nat Med. 2014;20:1242\u201353.","journal-title":"Nat Med"},{"key":"2393_CR15","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1126\/science.1127085","volume":"315","author":"D Mukhopadhyay","year":"2007","unstructured":"Mukhopadhyay D, Riezman H. Proteasome-independent functions of ubiquitin in endocytosis and signaling. Science. 2007;315:201\u20135.","journal-title":"Science"},{"key":"2393_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s11658-020-00245-6","volume":"26","author":"M Tracz","year":"2021","unstructured":"Tracz M, Bialek W. Beyond K48 and K63: non-canonical protein ubiquitination. Cell Mol Biol Lett. 2021;26:1.","journal-title":"Cell Mol Biol Lett"},{"key":"2393_CR17","doi-asserted-by":"publisher","first-page":"E1401","DOI":"10.1073\/pnas.1716673115","volume":"115","author":"F Ohtake","year":"2018","unstructured":"Ohtake F, Tsuchiya H, Saeki Y, Tanaka K. K63 ubiquitylation triggers proteasomal degradation by seeding branched ubiquitin chains. Proc Natl Acad Sci U S A. 2018;115:E1401\u20138.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2393_CR18","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1038\/nri2413","volume":"8","author":"K Ozato","year":"2008","unstructured":"Ozato K, Shin DM, Chang TH, Morse HC. TRIM family proteins and their emerging roles in innate immunity. Nat Rev Immunol. 2008;8:849\u201360.","journal-title":"Nat Rev Immunol"},{"key":"2393_CR19","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1124\/mol.116.106716","volume":"91","author":"B Huang","year":"2017","unstructured":"Huang B, Baek SH. Trim13 potentiates toll-like receptor 2-mediated nuclear factor \u03baB activation via K29-linked polyubiquitination of tumor necrosis factor receptor-associated factor 6. Mol Pharmacol. 2017;91:307\u201316.","journal-title":"Mol Pharmacol"},{"key":"2393_CR20","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1038\/ni1577","volume":"9","author":"M Shi","year":"2008","unstructured":"Shi M, Deng W, Bi E, Mao K, Ji Y, Lin G, et al. TRIM30 alpha negatively regulates TLR-mediated NF-kappa B activation by targeting TAB2 and TAB3 for degradation. Nat Immunol. 2008;9:369\u201377.","journal-title":"Nat Immunol"},{"key":"2393_CR21","doi-asserted-by":"publisher","first-page":"e1006600","DOI":"10.1371\/journal.ppat.1006600","volume":"13","author":"Q Yang","year":"2017","unstructured":"Yang Q, Liu TT, Lin H, Zhang M, Wei J, Luo WW, et al. TRIM32-TAX1BP1-dependent selective autophagic degradation of TRIF negatively regulates TLR3\/4-mediated innate immune responses. PLoS Pathog. 2017;13:e1006600.","journal-title":"PLoS Pathog"},{"key":"2393_CR22","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1073\/pnas.1318227111","volume":"111","author":"MM Hu","year":"2014","unstructured":"Hu MM, Yang Q, Zhang J, Liu SM, Zhang Y, Lin H, et al. TRIM38 inhibits TNF\u03b1- and IL-1\u03b2-triggered NF-\u03baB activation by mediating lysosome-dependent degradation of TAB2\/3. Proc Natl Acad Sci U S A. 2014;111:1509\u201314.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2393_CR23","doi-asserted-by":"publisher","first-page":"36404","DOI":"10.1074\/jbc.M112.397075","volume":"287","author":"Y Shen","year":"2012","unstructured":"Shen Y, Li NL, Wang J, Liu B, Lester S, Li K. TRIM56 is an essential component of the TLR3 antiviral signaling pathway. J Biol Chem. 2012;287:36404\u201313.","journal-title":"J Biol Chem"},{"key":"2393_CR24","doi-asserted-by":"publisher","first-page":"5311","DOI":"10.4049\/jimmunol.1103506","volume":"188","author":"W Zhao","year":"2012","unstructured":"Zhao W, Wang L, Zhang M, Wang P, Yuan C, Qi J, et al. Tripartite motif-containing protein 38 negatively regulates TLR3\/4- and RIG-I-mediated IFN-\u03b2 production and antiviral response by targeting NAP1. J Immunol. 2012;188:5311\u20138.","journal-title":"J Immunol"},{"key":"2393_CR25","doi-asserted-by":"publisher","first-page":"44417","DOI":"10.1074\/jbc.M304306200","volume":"278","author":"K Kitamura","year":"2003","unstructured":"Kitamura K, Tanaka H, Nishimune Y. Haprin, a novel haploid germ cell-specific RING finger protein involved in the acrosome reaction. J Biol Chem. 2003;278:44417\u201323.","journal-title":"J Biol Chem"},{"key":"2393_CR26","doi-asserted-by":"crossref","unstructured":"Mascaro M, Lages I, Meroni G. Microtubular TRIM36 E3 ubiquitin ligase in embryonic development and spermatogenesis. Cells. 2022;11.","DOI":"10.3390\/cells11020246"},{"key":"2393_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbrc.2022.08.053","volume":"628","author":"S Yu","year":"2022","unstructured":"Yu S, Li W, Liu X, Zhang H, Liu X, Zhang LW. TRIM36 enhances lung adenocarcinoma radiosensitivity and inhibits tumorigenesis through promoting RAD51 ubiquitination and antagonizing hsa-miR-376a-5p. Biochem Biophys Res Commun. 2022;628:1\u201310.","journal-title":"Biochem Biophys Res Commun"},{"key":"2393_CR28","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1038\/s41419-017-0197-y","volume":"9","author":"C Liang","year":"2018","unstructured":"Liang C, Wang S, Qin C, Bao M, Cheng G, Liu B, et al. TRIM36, a novel androgen-responsive gene, enhances anti-androgen efficacy against prostate cancer by inhibiting MAPK\/ERK signaling pathways. Cell Death Dis. 2018;9:155.","journal-title":"Cell Death Dis"},{"key":"2393_CR29","doi-asserted-by":"publisher","first-page":"e2304521","DOI":"10.1002\/advs.202304521","volume":"10","author":"X Liu","year":"2023","unstructured":"Liu X, Yan C, Chang C, Meng F, Shen W, Wang S, et al. FOXA2 suppression by TRIM36 exerts anti-tumor role in colorectal cancer via inducing NRF2\/GPX4-regulated ferroptosis. Adv Sci (Weinh). 2023;10:e2304521.","journal-title":"Adv Sci (Weinh)"},{"key":"2393_CR30","doi-asserted-by":"publisher","first-page":"2450","DOI":"10.1016\/j.immuni.2021.10.012","volume":"54","author":"T van der Poll","year":"2021","unstructured":"van der Poll T, Shankar-Hari M, Wiersinga WJ. The immunology of sepsis. Immunity. 2021;54:2450\u201364.","journal-title":"Immunity"},{"key":"2393_CR31","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1007\/s13238-013-2084-3","volume":"4","author":"Y Fan","year":"2013","unstructured":"Fan Y, Mao R, Yang J. NF-\u03baB and STAT3 signaling pathways collaboratively link inflammation to cancer. Protein Cell. 2013;4:176\u201385.","journal-title":"Protein Cell"},{"key":"2393_CR32","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1186\/s13045-020-00949-4","volume":"13","author":"J Yuan","year":"2020","unstructured":"Yuan J, Dong X, Yap J, Hu J. The MAPK and AMPK signalings: interplay and implication in targeted cancer therapy. J Hematol Oncol. 2020;13:113.","journal-title":"J Hematol Oncol"},{"key":"2393_CR33","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.it.2013.03.007","volume":"34","author":"AA Ajibade","year":"2013","unstructured":"Ajibade AA, Wang HY, Wang RF. Cell type-specific function of TAK1 in innate immune signaling. Trends Immunol. 2013;34:307\u201316.","journal-title":"Trends Immunol"},{"key":"2393_CR34","doi-asserted-by":"publisher","first-page":"608976","DOI":"10.3389\/fimmu.2020.608976","volume":"11","author":"YR Xu","year":"2020","unstructured":"Xu YR, Lei CQ. TAK1-TABs complex: a central signalosome in inflammatory responses. Front Immunol. 2020;11:608976.","journal-title":"Front Immunol"},{"key":"2393_CR35","doi-asserted-by":"publisher","first-page":"22102","DOI":"10.1016\/S0021-9258(18)41641-9","volume":"267","author":"KL Rhoades","year":"1992","unstructured":"Rhoades KL, Golub SH, Economou JS. The regulation of the human tumor necrosis factor alpha promoter region in macrophage, T cell, and B cell lines. J Biol Chem. 1992;267:22102\u20137.","journal-title":"J Biol Chem"},{"key":"2393_CR36","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1080\/21623945.2022.2107786","volume":"11","author":"X Zhang","year":"2022","unstructured":"Zhang X, Liu Z, Li W, Kang Y, Xu Z, Li X, et al. MAPKs\/AP-1, not NF-\u03baB, is responsible for MCP-1 production in TNF-\u03b1-activated adipocytes. Adipocyte. 2022;11:477\u201386.","journal-title":"Adipocyte"},{"key":"2393_CR37","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1007\/s00018-025-05865-9","volume":"82","author":"L Tian","year":"2025","unstructured":"Tian L, Yin S, Wang J, Xiao H, Kuang T, Luo L, et al. Neutrophilic granule protein promotes lipopolysaccharide-induced iNOS\/NO expression via JAK2\/STAT1 signaling pathway and augments bacteria clearance of macrophages. Cell Mol Life Sci. 2025;82:385.","journal-title":"Cell Mol Life Sci"}],"container-title":["Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00011-026-02393-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00011-026-02393-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00011-026-02393-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:18:51Z","timestamp":1792271931000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00011-026-02393-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,17]]},"references-count":37,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2393"],"URL":"https:\/\/doi.org\/10.1007\/s00011-026-02393-5","relation":{},"ISSN":["1420-908X"],"issn-type":[{"value":"1420-908X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,17]]},"assertion":[{"value":"1 June 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 September 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 October 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"243"}}