{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:08:50Z","timestamp":1791047330197,"version":"4.1.0"},"reference-count":203,"publisher":"Springer Science and Business Media LLC","issue":"15","license":[{"start":{"date-parts":[[2009,5,7]],"date-time":"2009-05-07T00:00:00Z","timestamp":1241654400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell. Mol. Life Sci."],"published-print":{"date-parts":[[2009,8]]},"DOI":"10.1007\/s00018-009-0034-2","type":"journal-article","created":{"date-parts":[[2009,6,25]],"date-time":"2009-06-25T14:44:48Z","timestamp":1245941088000},"page":"2503-2524","source":"Crossref","is-referenced-by-count":180,"title":["A comparative analysis of the cell biology of senescence and aging"],"prefix":"10.1007","volume":"66","author":[{"given":"Eun Seong","family":"Hwang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyesoon","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Tae","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,5,7]]},"reference":[{"key":"34_CR1","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1016\/S0531-5565(01)00160-7","volume":"36","author":"J Campisi","year":"2001","unstructured":"Campisi J, Kim SH, Lim CS, Rubio M (2001) Cellular senescence, cancer and aging: the telomere connection. Exp Gerontol 36:1619\u20131637","journal-title":"Exp Gerontol"},{"key":"34_CR2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1089\/ars.2008.2104","volume":"11","author":"M Muller","year":"2009","unstructured":"Muller M (2009) Cellular senescence: molecular mechanisms, in vivo significance, and redox considerations. Antioxid Redox Signal 11:59\u201398","journal-title":"Antioxid Redox Signal"},{"key":"34_CR3","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0092-8674(00)81902-9","volume":"88","author":"M Serrano","year":"1997","unstructured":"Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW (1997) Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88:593\u2013602","journal-title":"Cell"},{"key":"34_CR4","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.1101\/gad.12.19.2997","volume":"12","author":"J Zhu","year":"1998","unstructured":"Zhu J, Woods D, McMahon M, Bishop JM (1998) Senescence of human fibroblasts induced by oncogenic Raf. Genes Dev 12:2997\u20133007","journal-title":"Genes Dev"},{"key":"34_CR5","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/S0531-5565(00)00180-7","volume":"35","author":"O Toussaint","year":"2000","unstructured":"Toussaint O, Medrano EE, von Zglinicki T (2000) Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes. Exp Gerontol 35:927\u2013945","journal-title":"Exp Gerontol"},{"key":"34_CR6","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1056\/NEJMra062285","volume":"355","author":"WJ Mooi","year":"2006","unstructured":"Mooi WJ, Peeper DS (2006) Oncogene-induced cell senescence\u2014halting on the road to cancer. N Engl J Med 355:1037\u20131046","journal-title":"N Engl J Med"},{"key":"34_CR7","doi-asserted-by":"crossref","first-page":"12072","DOI":"10.1073\/pnas.211053698","volume":"98","author":"A Krtolica","year":"2001","unstructured":"Krtolica A, Parrinello S, Lockett S, Desprez PY, Campisi J (2001) Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging. Proc Natl Acad Sci USA 98:12072\u201312077","journal-title":"Proc Natl Acad Sci USA"},{"key":"34_CR8","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1006\/excr.2000.4875","volume":"257","author":"J Severino","year":"2000","unstructured":"Severino J, Allen RG, Balin S, Balin A, Cristofalo VJ (2000) Is beta-galactosidase staining a marker of senescence in vitro and in vivo? Exp Cell Res 257:162\u2013171","journal-title":"Exp Cell Res"},{"key":"34_CR9","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/S0741-5214(98)70064-3","volume":"28","author":"MV Mendez","year":"1998","unstructured":"Mendez MV, Stanley A, Park HY, Shon K, Phillips T, Menzoian JO (1998) Fibroblasts cultured from venous ulcers display cellular characteristics of senescence. J Vasc Surg 28:876\u2013883","journal-title":"J Vasc Surg"},{"key":"34_CR10","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1161\/01.CIR.0000013836.85741.17","volume":"105","author":"T Minamino","year":"2002","unstructured":"Minamino T, Miyauchi H, Yoshida T, Ishida Y, Yoshida H, Komuro I (2002) Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction. Circulation 105:1541\u20131544","journal-title":"Circulation"},{"key":"34_CR11","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1046\/j.1474-9728.2002.00008.x","volume":"1","author":"JS Price","year":"2002","unstructured":"Price JS, Waters JG, Darrah C, Pennington C, Edwards DR, Donell ST, Clark IM (2002) The role of chondrocyte senescence in osteoarthritis. Aging Cell 1:57\u201365","journal-title":"Aging Cell"},{"key":"34_CR12","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1093\/geronj\/38.5.513","volume":"38","author":"A Plisko","year":"1983","unstructured":"Plisko A, Gilchrest BA (1983) Growth factor responsiveness of cultured human fibroblasts declines with age. J Gerontol 38:513\u2013518","journal-title":"J Gerontol"},{"key":"34_CR13","doi-asserted-by":"crossref","first-page":"B239","DOI":"10.1093\/gerona\/57.6.B239","volume":"57","author":"JR Smith","year":"2002","unstructured":"Smith JR, Venable S, Roberts TW, Metter EJ, Monticone R, Schneider EL (2002) Relationship between in vivo age and in vitro aging: assessment of 669 cell cultures derived from members of the Baltimore Longitudinal Study of Aging. J Gerontol A Biol Sci Med Sci 57:B239\u2013B246","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"34_CR14","doi-asserted-by":"crossref","first-page":"10614","DOI":"10.1073\/pnas.95.18.10614","volume":"95","author":"VJ Cristofalo","year":"1998","unstructured":"Cristofalo VJ, Allen RG, Pignolo RJ, Martin BG, Beck JC (1998) Relationship between donor age and the replicative lifespan of human cells in culture: a reevaluation. Proc Natl Acad Sci USA 95:10614\u201310619","journal-title":"Proc Natl Acad Sci USA"},{"key":"34_CR15","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1006\/bbrc.1998.8322","volume":"244","author":"G Tesco","year":"1998","unstructured":"Tesco G, Vergelli M, Grassilli E, Salomoni P, Bellesia E, Sikora E, Radziszewska E, Barbieri D, Latorraca S, Fagiolo U, Santacaterina S, Amaducci L, Tiozzo R, Franceschi C, Sorbi S (1998) Growth properties and growth factor responsiveness in skin fibroblasts from centenarians. Biochem Biophys Res Commun 244:912\u2013916","journal-title":"Biochem Biophys Res Commun"},{"key":"34_CR16","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.mad.2006.11.008","volume":"128","author":"JC Jeyapalan","year":"2007","unstructured":"Jeyapalan JC, Ferreira M, Sedivy JM, Herbig U (2007) Accumulation of senescent cells in mitotic tissue of aging primates. Mech Ageing Dev 128:36\u201344","journal-title":"Mech Ageing Dev"},{"key":"34_CR17","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0014-4827(84)90679-7","volume":"154","author":"E Wang","year":"1984","unstructured":"Wang E, Gundersen D (1984) Increased organization of cytoskeleton accompanying the aging of human fibroblasts in vitro. Exp Cell Res 154:191\u2013202","journal-title":"Exp Cell Res"},{"key":"34_CR18","first-page":"313","volume":"19","author":"VJ Cristofalo","year":"1969","unstructured":"Cristofalo VJ, Kritchevsky D (1969) Cell size and nucleic acid content in the diploid human cell line WI-38 during aging. Med Exp Int J Exp Med 19:313\u2013320","journal-title":"Med Exp Int J Exp Med"},{"key":"34_CR19","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/BF02616174","volume":"13","author":"SB Greenberg","year":"1977","unstructured":"Greenberg SB, Grove GL, Cristofalo VJ (1977) Cell size in aging monolayer cultures. In Vitro 13:297\u2013300","journal-title":"In Vitro"},{"key":"34_CR20","doi-asserted-by":"crossref","first-page":"10978","DOI":"10.1073\/pnas.97.20.10978","volume":"97","author":"EC Goodwin","year":"2000","unstructured":"Goodwin EC, Yang E, Lee CJ, Lee HW, DiMaio D, Hwang ES (2000) Rapid induction of senescence in human cervical carcinoma cells. Proc Natl Acad Sci USA 97:10978\u201310983","journal-title":"Proc Natl Acad Sci USA"},{"key":"34_CR21","doi-asserted-by":"crossref","first-page":"4087","DOI":"10.1242\/jcs.113.22.4087","volume":"113","author":"QM Chen","year":"2000","unstructured":"Chen QM, Tu VC, Catania J, Burton M, Toussaint O, Dilley T (2000) Involvement of Rb family proteins, focal adhesion proteins and protein synthesis in senescent morphogenesis induced by hydrogen peroxide. J Cell Sci 113:4087\u20134097","journal-title":"J Cell Sci"},{"key":"34_CR22","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1042\/bj20040095","volume":"380","author":"E Hutter","year":"2004","unstructured":"Hutter E, Renner K, Pfister G, Stockl P, Jansen-Durr P, Gnaiger E (2004) Senescence-associated changes in respiration and oxidative phosphorylation in primary human fibroblasts. Biochem J 380:919\u2013928","journal-title":"Biochem J"},{"key":"34_CR23","doi-asserted-by":"crossref","first-page":"17826","DOI":"10.1074\/jbc.M311980200","volume":"279","author":"C Martin-Ruiz","year":"2004","unstructured":"Martin-Ruiz C, Saretzki G, Petrie J, Ladhoff J, Jeyapalan J, Wei W, Sedivy J, von Zglinicki T (2004) Stochastic variation in telomere shortening rate causes heterogeneity of human fibroblast replicative life span. J Biol Chem 279:17826\u201317833","journal-title":"J Biol Chem"},{"key":"34_CR24","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/nbt0303-229b","volume":"21","author":"Tv Zglinicki","year":"2003","unstructured":"Zglinicki Tv, Petrie J, Kirkwood TBL (2003) Telomere-driven replicative senescence is a stress response. Nat Biotech 21:229\u2013230","journal-title":"Nat Biotech"},{"key":"34_CR25","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1002\/jcp.20750","volume":"209","author":"MV Blagosklonny","year":"2006","unstructured":"Blagosklonny MV (2006) Cell senescence: hypertrophic arrest beyond the restriction point. J Cell Physiol 209:592\u2013597","journal-title":"J Cell Physiol"},{"key":"34_CR26","doi-asserted-by":"crossref","first-page":"6416","DOI":"10.1038\/sj.onc.1209888","volume":"25","author":"Y Mamane","year":"2006","unstructured":"Mamane Y, Petroulakis E, LeBacquer O, Sonenberg N (2006) mTOR, translation initiation and cancer. Oncogene 25:6416\u20136422","journal-title":"Oncogene"},{"key":"34_CR27","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1101\/gad.995802","volume":"16","author":"DC Fingar","year":"2002","unstructured":"Fingar DC, Salama S, Tsou C, Harlow E, Blenis J (2002) Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1\/eIF4E. Genes Dev 16:1472\u20131487","journal-title":"Genes Dev"},{"key":"34_CR28","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1124\/jpet.300.3.1101","volume":"300","author":"VC Tu","year":"2002","unstructured":"Tu VC, Bahl JJ, Chen QM (2002) Signals of oxidant-induced cardiomyocyte hypertrophy: key activation of p70 S6 kinase-1 and phosphoinositide 3-kinase. J Pharmacol Exp Ther 300:1101\u20131110","journal-title":"J Pharmacol Exp Ther"},{"key":"34_CR29","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.yexcr.2004.04.012","volume":"298","author":"Y Wang","year":"2004","unstructured":"Wang Y, Meng A, Zhou D (2004) Inhibition of phosphatidylinostol 3-kinase uncouples H2O2-induced senescent phenotype and cell cycle arrest in normal human diploid fibroblasts. Exp Cell Res 298:188\u2013196","journal-title":"Exp Cell Res"},{"key":"34_CR30","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0047-6374(80)90106-2","volume":"14","author":"L Hayflick","year":"1980","unstructured":"Hayflick L (1980) Recent advances in the cell biology of aging. Mech Ageing Dev 14:59\u201379","journal-title":"Mech Ageing Dev"},{"key":"34_CR31","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0047-6374(77)90039-2","volume":"6","author":"S Razin","year":"1977","unstructured":"Razin S, Pfendt EA, Matsumura T, Hayflick L (1977) Comparison by autoradiography of macromolecular biosynthesis in \u201cyoung\u201d and \u201cold\u201d human diploid fibroblast cultures. A brief note. Mech Ageing Dev 6:379\u2013384","journal-title":"Mech Ageing Dev"},{"key":"34_CR32","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1096\/fj.00-0723fje","volume":"15","author":"JS Park","year":"2001","unstructured":"Park JS, Park WY, Cho KA, Kim DI, Jhun BH, Kim SR, Park SC (2001) Down-regulation of amphiphysin-1 is responsible for reduced receptor-mediated endocytosis in the senescent cells. FASEB J 15:1625\u20131627","journal-title":"FASEB J"},{"key":"34_CR33","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1083\/jcb.100.5.1466","volume":"100","author":"E Wang","year":"1985","unstructured":"Wang E (1985) Are cross-bridging structures involved in the bundle formation of intermediate filaments and the decrease in locomotion that accompany cell aging? J Cell Biol 100:1466\u20131473","journal-title":"J Cell Biol"},{"key":"34_CR34","first-page":"229","volume-title":"Handbook of cell biology of aging","author":"D Knook","year":"1985","unstructured":"Knook D (1985) Aging liver cells. In: Cristofalo V (ed) Handbook of cell biology of aging. CRC Press, Boca Raton, pp 229\u2013243"},{"key":"34_CR35","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.1749-6632.1992.tb38648.x","volume":"663","author":"SI Rattan","year":"1992","unstructured":"Rattan SI, Derventzi A, Clark BF (1992) Protein synthesis, posttranslational modifications, and aging. Ann N Y Acad Sci 663:48\u201362","journal-title":"Ann N Y Acad Sci"},{"key":"34_CR36","first-page":"171","volume-title":"Handbook of physiology: aging","author":"H Remmen Van","year":"1995","unstructured":"Van Remmen H, Ward W, Sabia R, Richardson A (1995) Gene expression and protein degradation. In: Masoro E (ed) Handbook of physiology: aging. Oxford University Press, Oxford, pp 171\u2013443"},{"key":"34_CR37","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1002\/hep.1840140529","volume":"14","author":"W Ward","year":"1991","unstructured":"Ward W, Richardson A (1991) Effect of age on liver protein synthesis and degradation. Hepatology 14:935\u2013948","journal-title":"Hepatology"},{"key":"34_CR38","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s004180100325","volume":"116","author":"K Nishio","year":"2001","unstructured":"Nishio K, Inoue A, Qiao S, Kondo H, Mimura A (2001) Senescence and cytoskeleton: overproduction of vimentin induces senescent-like morphology in human fibroblasts. Histochem Cell Biol 116:321\u2013327","journal-title":"Histochem Cell Biol"},{"key":"34_CR39","doi-asserted-by":"crossref","first-page":"5321","DOI":"10.1128\/MCB.11.10.5321","volume":"11","author":"MV Eiden","year":"1991","unstructured":"Eiden MV, MacArthur L, Okayama H (1991) Suppression of the chemically transformed phenotype of BHK cells by a human cDNA. Mol Cell Biol 11:5321\u20135329","journal-title":"Mol Cell Biol"},{"key":"34_CR40","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1089\/104454901317094945","volume":"20","author":"GV Tolstonog","year":"2001","unstructured":"Tolstonog GV, Shoeman RL, Traub U, Traub P (2001) Role of the intermediate filament protein vimentin in delaying senescence and in the spontaneous immortalization of mouse embryo fibroblasts. DNA Cell Biol 20:509\u2013529","journal-title":"DNA Cell Biol"},{"key":"34_CR41","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/BF00054016","volume":"15","author":"MJ Hendrix","year":"1996","unstructured":"Hendrix MJ, Seftor EA, Chu YW, Trevor KT, Seftor RE (1996) Role of intermediate filaments in migration, invasion and metastasis. Cancer Metastasis Rev 15:507\u2013525","journal-title":"Cancer Metastasis Rev"},{"key":"34_CR42","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1016\/S0021-9258(18)53979-X","volume":"268","author":"A Lilienbaum","year":"1993","unstructured":"Lilienbaum A, Paulin D (1993) Activation of the human vimentin gene by the Tax human T-cell leukemia virus. I. Mechanisms of regulation by the NF-kappa B transcription factor. J Biol Chem 268:2180\u20132188","journal-title":"J Biol Chem"},{"key":"34_CR43","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.exger.2003.09.007","volume":"38","author":"K Gosselin","year":"2003","unstructured":"Gosselin K, Abbadie C (2003) Involvement of Rel\/NF-kappa B transcription factors in senescence. Exp Gerontol 38:1271\u20131283","journal-title":"Exp Gerontol"},{"key":"34_CR44","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s004280050079","volume":"431","author":"MP Miguel de","year":"1997","unstructured":"de Miguel MP, Bethencourt FR, Arenas MI, Fraile B, Paniagua R (1997) Intermediate filaments in the Sertoli cells of the ageing human testis. Virchows Arch 431:131\u2013138","journal-title":"Virchows Arch"},{"key":"34_CR45","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/ar.1092430115","volume":"243","author":"MT Berciano","year":"1995","unstructured":"Berciano MT, Andres MA, Calle E, Lafarga M (1995) Age-induced hypertrophy of astrocytes in rat supraoptic nucleus: a cytological, morphometric, and immunocytochemical study. Anat Rec 243:129\u2013144","journal-title":"Anat Rec"},{"key":"34_CR46","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S0003-9969(98)00033-8","volume":"43","author":"YC Bae","year":"1998","unstructured":"Bae YC, Park KP, Park MJ, Ihn HJ (1998) Development of vimentin filaments in the cells of the articular disc of the rat squamosomandibular joint with age. Arch Oral Biol 43:579\u2013583","journal-title":"Arch Oral Biol"},{"key":"34_CR47","doi-asserted-by":"crossref","first-page":"23427","DOI":"10.1074\/jbc.M701586200","volume":"282","author":"T Kueper","year":"2007","unstructured":"Kueper T, Grune T, Prahl S, Lenz H, Welge V, Biernoth T, Vogt Y, Muhr GM, Gaemlich A, Jung T, Boemke G, Elsasser HP, Wittern KP, Wenck H, Stab F, Blatt T (2007) Vimentin is the specific target in skin glycation. Structural prerequisites, functional consequences, and role in skin aging. J Biol Chem 282:23427\u201323436","journal-title":"J Biol Chem"},{"key":"34_CR48","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1083\/jcb.109.4.1653","volume":"109","author":"Y Capetanaki","year":"1989","unstructured":"Capetanaki Y, Smith S, Heath JP (1989) Overexpression of the vimentin gene in transgenic mice inhibits normal lens cell differentiation. J Cell Biol 109:1653\u20131664","journal-title":"J Cell Biol"},{"key":"34_CR49","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s00418-005-0766-5","volume":"123","author":"K Nishio","year":"2005","unstructured":"Nishio K, Inoue A (2005) Senescence-associated alterations of cytoskeleton: extraordinary production of vimentin that anchors cytoplasmic p53 in senescent human fibroblasts. Histochem Cell Biol 123:263\u2013273","journal-title":"Histochem Cell Biol"},{"key":"34_CR50","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.mad.2008.05.008","volume":"129","author":"K Oender","year":"2008","unstructured":"Oender K, Trost A, Lanschuetzer C, Laimer M, Emberger M, Breitenbach M, Richter K, Hintner H, Bauer JW (2008) Cytokeratin-related loss of cellular integrity is not a major driving force of human intrinsic skin aging. Mech Ageing Dev 129:563\u2013571","journal-title":"Mech Ageing Dev"},{"key":"34_CR51","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.mad.2006.05.003","volume":"127","author":"SM Arnesen","year":"2006","unstructured":"Arnesen SM, Lawson MA (2006) Age-related changes in focal adhesions lead to altered cell behavior in tendon fibroblasts. Mech Ageing Dev 127:726\u2013732","journal-title":"Mech Ageing Dev"},{"key":"34_CR52","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1074\/mcp.M200051-MCP200","volume":"2","author":"P Gromov","year":"2003","unstructured":"Gromov P, Skovgaard GL, Palsdottir H, Gromova I, Ostergaard M, Celis JE (2003) Protein profiling of the human epidermis from the elderly reveals up-regulation of a signature of interferon-\u03b3-induced polypeptides that includes manganese-superoxide dismutase and the p85\u03b2 Subunit of phosphatidylinositol 3-kinase. Mol Cell Proteomics 2:70\u201384","journal-title":"Mol Cell Proteomics"},{"key":"34_CR53","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1093\/gerona\/61.12.1232","volume":"61","author":"X Chen","year":"2006","unstructured":"Chen X, Li Z, Feng Z, Wang J, Ouyang C, Liu W, Fu B, Cai G, Wu C, Wei R, Wu D, Hong Q (2006) Integrin-linked kinase induces both senescence-associated alterations and extracellular fibronectin assembly in aging cardiac fibroblasts. J Gerontol A Biol Sci Med Sci 61:1232\u20131245","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"34_CR54","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1016\/j.febslet.2008.04.010","volume":"582","author":"MK Vartiainen","year":"2008","unstructured":"Vartiainen MK (2008) Nuclear actin dynamics\u2014from form to function. FEBS Lett 582:2033\u20132040","journal-title":"FEBS Lett"},{"key":"34_CR55","doi-asserted-by":"crossref","first-page":"26040","DOI":"10.1016\/S0021-9258(18)47156-6","volume":"269","author":"ME Venable","year":"1994","unstructured":"Venable ME, Blobe GC, Obeid LM (1994) Identification of a defect in the phospholipase D\/diacylglycerol pathway in cellular senescence. J Biol Chem 269:26040\u201326044","journal-title":"J Biol Chem"},{"key":"34_CR56","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/cm.970220206","volume":"22","author":"JL Rodriguez Fernandez","year":"1992","unstructured":"Rodriguez Fernandez JL, Geiger B, Salomon D, Ben-Ze\u2019ev A (1992) Overexpression of vinculin suppresses cell motility in BALB\/c 3T3 cells. Cell Motil Cytoskeleton 22:127\u2013134","journal-title":"Cell Motil Cytoskeleton"},{"key":"34_CR57","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1083\/jcb.122.6.1285","volume":"122","author":"JL Rodriguez Fernandez","year":"1993","unstructured":"Rodriguez Fernandez JL, Geiger B, Salomon D, Ben-Ze\u2019ev A (1993) Suppression of vinculin expression by antisense transfection confers changes in cell morphology, motility, and anchorage-dependent growth of 3T3 cells. J Cell Biol 122:1285\u20131294","journal-title":"J Cell Biol"},{"key":"34_CR58","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/S1357-2725(97)00051-4","volume":"29","author":"J-L Guan","year":"1997","unstructured":"Guan J-L (1997) Role of focal adhesion kinase in integrin signaling. Int J Biochem Cell Biol 29:1085\u20131096","journal-title":"Int J Biochem Cell Biol"},{"key":"34_CR59","doi-asserted-by":"crossref","first-page":"42270","DOI":"10.1074\/jbc.M402352200","volume":"279","author":"KA Cho","year":"2004","unstructured":"Cho KA, Ryu SJ, Oh YS, Park JH, Lee JW, Kim H-P, Kim KT, Jang IS, Park SC (2004) Morphological adjustment of senescent cells by modulating caveolin-1 status. J Biol Chem 279:42270\u201342278","journal-title":"J Biol Chem"},{"key":"34_CR60","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1083\/jcb.200108077","volume":"155","author":"C Wu","year":"2001","unstructured":"Wu C, Dedhar S (2001) Integrin-linked kinase (ILK) and its interactors: a new paradigm for the coupling of extracellular matrix to actin cytoskeleton and signaling complexes. J Cell Biol 155:505\u2013510","journal-title":"J Cell Biol"},{"key":"34_CR61","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s10522-006-9066-2","volume":"8","author":"KM Rice","year":"2007","unstructured":"Rice KM, Desai DH, Kinnard RS, Harris R, Wright GL, Blough ER (2007) Load-induced focal adhesion mechanotransduction is altered with aging in the Fischer 344\/NNiaHSd x Brown Norway\/BiNia rat aorta. Biogerontology 8:257\u2013267","journal-title":"Biogerontology"},{"key":"34_CR62","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0531-5565(96)00080-0","volume":"32","author":"T Kumazaki","year":"1997","unstructured":"Kumazaki T, Wadhwa R, Kaul SC, Mitsui Y (1997) Expression of endothelin, fibronectin, and mortalin as aging and mortality markers. Exp Gerontol 32:95\u2013103","journal-title":"Exp Gerontol"},{"key":"34_CR63","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1006\/excr.1994.1181","volume":"213","author":"P Rasoamanantena","year":"1994","unstructured":"Rasoamanantena P, Thweatt R, Labat-Robert J, Goldstein S (1994) Altered regulation of fibronectin gene expression in Werner syndrome fibroblasts. Exp Cell Res 213:121\u2013127","journal-title":"Exp Cell Res"},{"key":"34_CR64","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0167-4943(00)00071-6","volume":"31","author":"J Labat-Robert","year":"2000","unstructured":"Labat-Robert J, Marques MA, N\u2019Doye S, Alperovitch A, Moulias R, Allard M, Robert L (2000) Plasma fibronectin in French centenarians. Arch Gerontol Geriatr 31:95\u2013105","journal-title":"Arch Gerontol Geriatr"},{"key":"34_CR65","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0014-4827(70)90451-9","volume":"61","author":"DE Comings","year":"1970","unstructured":"Comings DE, Okada TA (1970) Electron microscopy of human fibroblasts in tissue culture during logarithmic and confluent stages of growth. Exp Cell Res 61:295\u2013301","journal-title":"Exp Cell Res"},{"key":"34_CR66","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0022-5320(72)80005-4","volume":"39","author":"J Lipetz","year":"1972","unstructured":"Lipetz J, Cristofalo VJ (1972) Ultrastructural changes accompanying the aging of human diploid cells in culture. J Ultrastruct Res 39:43\u201356","journal-title":"J Ultrastruct Res"},{"key":"34_CR67","first-page":"521","volume":"29","author":"JH Park","year":"2007","unstructured":"Park JH, Yi HW, DiMaio D, Hwang ES (2007) Heterogeneous upregulation of lysosomal genes in human fibroblasts and cancer cells undergoing senescence. Korean J Genet 29:521\u2013527","journal-title":"Korean J Genet"},{"key":"34_CR68","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0047-6374(84)90094-0","volume":"26","author":"W Priester De","year":"1984","unstructured":"De Priester W, Van Manen R, Knook DL (1984) Lysosomal activity in the aging rat liver: II. Morphometry of acid phosphatase positive dense bodies. Mech Ageing Dev 26:205\u2013216","journal-title":"Mech Ageing Dev"},{"key":"34_CR69","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0047-6374(82)90085-9","volume":"18","author":"EA Porta","year":"1982","unstructured":"Porta EA, Sablan HM, Joun NS, Chee G (1982) Effects of the type of dietary fat at two levels of vitamin E in Wistar male rats during development and aging. IV. Biochemical and morphometric parameters of the heart. Mech Ageing Dev 18:159\u2013199","journal-title":"Mech Ageing Dev"},{"key":"34_CR70","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0167-4943(01)00218-7","volume":"34","author":"DL Schmucker","year":"2002","unstructured":"Schmucker DL, Sachs H (2002) Quantifying dense bodies and lipofuscin during aging: a morphologist\u2019s perspective. Arch Gerontol Geriatr 34:249\u2013261","journal-title":"Arch Gerontol Geriatr"},{"key":"34_CR71","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1084\/jem.131.6.1211","volume":"131","author":"E Robbins","year":"1970","unstructured":"Robbins E, Levine EM, Eagle H (1970) Morphologic changes accompanying senescence of cultured human diploid cells. J Exp Med 131:1211\u20131222","journal-title":"J Exp Med"},{"key":"34_CR72","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/S0531-5565(03)00114-1","volume":"38","author":"A Terman","year":"2003","unstructured":"Terman A, Dalen H, Eaton JW, Neuzil J, Brunk UT (2003) Mitochondrial recycling and aging of cardiac myocytes: the role of autophagocytosis. Exp Gerontol 38:863\u2013876","journal-title":"Exp Gerontol"},{"key":"34_CR73","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/j.bbagen.2008.01.009","volume":"1780","author":"T Kurz","year":"2008","unstructured":"Kurz T, Terman A, Gustafsson B, Brunk UT (2008) Lysosomes and oxidative stress in aging and apoptosis. Biochimi Biophys Acta 1780:1291\u20131303","journal-title":"Biochimi Biophys Acta"},{"key":"34_CR74","doi-asserted-by":"crossref","first-page":"26217","DOI":"10.1074\/jbc.M803287200","volume":"283","author":"J Lapointe","year":"2008","unstructured":"Lapointe J, Hekimi S (2008) Early mitochondrial dysfunction in long-lived Mclk1 +\/\u2212 mice. J Biol Chem 283:26217\u201326227","journal-title":"J Biol Chem"},{"key":"34_CR75","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0047-6374(76)90018-X","volume":"5","author":"VP Collins","year":"1976","unstructured":"Collins VP, Brunk UT (1976) Characterization of residual bodies formed in phase II cultivated human glia cells. Mech Ageing Dev 5:193\u2013207","journal-title":"Mech Ageing Dev"},{"key":"34_CR76","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0047-6374(76)90036-1","volume":"5","author":"DL Knook","year":"1976","unstructured":"Knook DL, Sleyster EC (1976) Lysosomal enzyme activities in parenchymal and nonparenchymal liver cells isolated from young, adult and old rats. Mech Ageing Dev 5:389\u2013398","journal-title":"Mech Ageing Dev"},{"key":"34_CR77","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1474-9726.2006.00199.x","volume":"5","author":"BY Lee","year":"2006","unstructured":"Lee BY, Han JA, Im JS, Morrone A, Johung K, Goodwin EC, Kleijer WJ, DiMaio D, Hwang ES (2006) Senescence-associated \u03b2-galactosidase is lysosomal \u03b2-galactosidase. Aging Cell 5:187\u2013195","journal-title":"Aging Cell"},{"key":"34_CR78","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0047-6374(97)00093-6","volume":"99","author":"MM Sanchez-Martin","year":"1997","unstructured":"Sanchez-Martin MM, Cabezas JA (1997) Evaluation of the activities of eight lysosomal hydrolases in sera of humans, rats and pigs of different ages. Mech Ageing Dev 99:95\u2013107","journal-title":"Mech Ageing Dev"},{"key":"34_CR79","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1128\/JVI.02348-06","volume":"81","author":"K Johung","year":"2007","unstructured":"Johung K, Goodwin EC, DiMaio D (2007) Human papillomavirus E7 repression in cervical carcinoma cells initiates a transcriptional cascade driven by the retinoblastoma family, resulting in senescence. J Virol 81:2102\u20132116","journal-title":"J Virol"},{"key":"34_CR80","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.mad.2006.07.001","volume":"127","author":"Y Sato","year":"2006","unstructured":"Sato Y, Suzuki Y, Ito E, Shimazaki S, Ishida M, Yamamoto T, Yamamoto H, Toda T, Suzuki M, Suzuki A, Endo T (2006) Identification and characterization of an increased glycoprotein in aging: age-associated translocation of cathepsin D. Mech Ageing Dev 127:771\u2013778","journal-title":"Mech Ageing Dev"},{"key":"34_CR81","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1179\/135100001101536094","volume":"6","author":"UT Brunk","year":"2001","unstructured":"Brunk UT, Neuzil J, Eaton JW (2001) Lysosomal involvement in apoptosis. Redox Rep 6:91\u201397","journal-title":"Redox Rep"},{"key":"34_CR82","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1042\/BJ20041650","volume":"387","author":"M Tenopoulou","year":"2005","unstructured":"Tenopoulou M, Doulias P-T, Barbouti A, Brunk U, Galaris D (2005) Role of compartmentalized redox-active iron in hydrogen peroxide-induced DNA damage and apoptosis. Biochem J 387:703\u2013710","journal-title":"Biochem J"},{"key":"34_CR83","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/S0891-5849(03)00109-6","volume":"34","author":"Z Yu","year":"2003","unstructured":"Yu Z, Persson HL, Eaton JW, Brunk UT (2003) Intralysosomal iron: a major determinant of oxidant-induced cell death. Free Radic Biol Med 34:1243\u20131252","journal-title":"Free Radic Biol Med"},{"key":"34_CR84","doi-asserted-by":"crossref","first-page":"9363","DOI":"10.1073\/pnas.92.20.9363","volume":"92","author":"GP Dimri","year":"1995","unstructured":"Dimri GP, Lee X, Basile G, Acosta M, Scott G, Roskelley C, Medrano EE, Linskens M, Rubelj I, Pereira-Smith O et al (1995) A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 92:9363\u20139367","journal-title":"Proc Natl Acad Sci USA"},{"key":"34_CR85","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1046\/j.1523-1755.2003.00032.x","volume":"63","author":"A Melk","year":"2003","unstructured":"Melk A, Kittikowit W, Sandhu I, Halloran KM, Grimm P, Schmidt BMW, Halloran PF (2003) Cell senescence in rat kidneys in vivo increases with growth and age despite lack of telomere shortening. Kidney Int 63:2134\u20132143","journal-title":"Kidney Int"},{"key":"34_CR86","first-page":"1590","volume":"40","author":"K Mishima","year":"1999","unstructured":"Mishima K, Handa JT, Aotaki-Keen A, Lutty GA, Morse LS, Hjelmeland LM (1999) Senescence-associated beta-galactosidase histochemistry for the primate eye. Invest Ophthalmol Vis Sci 40:1590\u20131593","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"34_CR87","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/(SICI)1097-4652(199907)180:1<123::AID-JCP14>3.0.CO;2-W","volume":"180","author":"WR Pendergrass","year":"1999","unstructured":"Pendergrass WR, Lane MA, Bodkin NL, Hansen BC, Ingram DK, Roth GS, Yi L, Bin H, Wolf NS (1999) Cellular proliferation potential during aging and caloric restriction in rhesus monkeys {Macaca mulatta}. J Cell Physiol 180:123\u2013130","journal-title":"J Cell Physiol"},{"key":"34_CR88","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1196\/annals.1297.097","volume":"1019","author":"S Kishi","year":"2004","unstructured":"Kishi S (2004) Functional aging and gradual senescence in zebrafish. Ann N Y Acad Sci 1019:521\u2013526","journal-title":"Ann N Y Acad Sci"},{"key":"34_CR89","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1002\/path.1073","volume":"196","author":"PJ Coates","year":"2002","unstructured":"Coates PJ (2002) Markers of senescence? J Pathol 196:371\u2013373","journal-title":"J Pathol"},{"key":"34_CR90","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0047-6374(99)00105-0","volume":"113","author":"RE Mouton","year":"2000","unstructured":"Mouton RE, Venable ME (2000) Ceramide induces expression of the senescence histochemical marker, \u03b2-galactosidase, in human fibroblasts. Mech Ageing Dev 113:169\u2013181","journal-title":"Mech Ageing Dev"},{"key":"34_CR91","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.exger.2005.08.005","volume":"40","author":"VJ Cristofalo","year":"2005","unstructured":"Cristofalo VJ (2005) SA \u03b2-Gal staining: biomarker or delusion. Exp Gerontol 40:836\u2013838","journal-title":"Exp Gerontol"},{"key":"34_CR92","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0047-6374(99)00031-7","volume":"109","author":"DR Krishna","year":"1999","unstructured":"Krishna DR, Sperker B, Fritz P, Klotz U (1999) Does pH 6 \u03b2-galactosidase activity indicate cell senescence? Mech Ageing Dev 109:113\u2013123","journal-title":"Mech Ageing Dev"},{"key":"34_CR93","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/j.exger.2003.08.008","volume":"38","author":"G Untergasser","year":"2003","unstructured":"Untergasser G, Gander R, Rumpold H, Heinrich E, Plas E, Berger P (2003) TGF-\u03b2 cytokines increase senescence-associated beta-galactosidase activity in human prostate basal cells by supporting differentiation processes, but not cellular senescence. Exp Gerontol 38:1179\u20131188","journal-title":"Exp Gerontol"},{"key":"34_CR94","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.exger.2005.07.011","volume":"40","author":"N-C Yang","year":"2005","unstructured":"Yang N-C, Hu M-L (2005) The limitations and validities of senescence associated-[beta]-galactosidase activity as an aging marker for human foreskin fibroblast Hs68 cells. Exp Gerontol 40:813\u2013819","journal-title":"Exp Gerontol"},{"key":"34_CR95","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1006\/excr.1998.4169","volume":"243","author":"YE Yegorov","year":"1998","unstructured":"Yegorov YE, Akimov SS, Hass R, Zelenin AV, Prudovsky IA (1998) Endogenous \u03b2-galactosidase activity in continuously nonproliferating cells. Exp Cell Res 243:207\u2013211","journal-title":"Exp Cell Res"},{"key":"34_CR96","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.ab.2005.06.003","volume":"343","author":"RK Gary","year":"2005","unstructured":"Gary RK, Kindell SM (2005) Quantitative assay of senescence-associated \u03b2-galactosidase activity in mammalian cell extracts. Anal Biochem 343:329\u2013334","journal-title":"Anal Biochem"},{"key":"34_CR97","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/S0531-5565(03)00132-3","volume":"38","author":"L-M Gerland","year":"2003","unstructured":"Gerland L-M, Peyrol S, Lallemand C, Branche R, Magaud J-P, Ffrench M (2003) Association of increased autophagic inclusions labeled for \u03b2-galactosidase with fibroblastic aging. Exp Gerontol 38:887\u2013895","journal-title":"Exp Gerontol"},{"key":"34_CR98","doi-asserted-by":"crossref","first-page":"3613","DOI":"10.1242\/jcs.113.20.3613","volume":"113","author":"DJ Kurz","year":"2000","unstructured":"Kurz DJ, Decary S, Hong Y, Erusalimsky JD (2000) Senescence-associated \u03b2-galactosidase reflects an increase in lysosomal mass during replicative ageing of human endothelial cells. J Cell Sci 113:3613\u20133622","journal-title":"J Cell Sci"},{"key":"34_CR99","first-page":"3761","volume":"59","author":"B-D Chang","year":"1999","unstructured":"Chang B-D, Broude EV, Dokmanovic M, Zhu H, Ruth A, Xuan Y, Kandel ES, Lausch E, Christov K, Roninson IB (1999) A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents. Cancer Res 59:3761\u20133767","journal-title":"Cancer Res"},{"key":"34_CR100","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1111\/j.1474-9726.2008.00436.x","volume":"7","author":"YH Seo","year":"2008","unstructured":"Seo YH, Jung HJ, Shin HT, Kim YM, Yim H, Chung HY, Lim IK, Yoon G (2008) Enhanced glycogenesis is involved in cellular senescence via GSK3\/GS modulation. Aging Cell 7:894\u2013907","journal-title":"Aging Cell"},{"key":"34_CR101","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0022-510X(81)90012-5","volume":"52","author":"SA Moore","year":"1981","unstructured":"Moore SA, Peterson RG, Felten DL, O\u2019Connor BL (1981) Glycogen accumulation in tibial nerves of experimentally diabetic and aging control rats. J Neurol Sci 52:289\u2013303","journal-title":"J Neurol Sci"},{"key":"34_CR102","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0047-6374(85)90024-7","volume":"31","author":"HJ Gertz","year":"1985","unstructured":"Gertz HJ, Cervos-Navarro J, Frydl V, Schultz F (1985) Glycogen accumulation of the aging human brain. Mech Ageing Dev 31:25\u201335","journal-title":"Mech Ageing Dev"},{"key":"34_CR103","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1006\/dbio.2000.9816","volume":"225","author":"DM Ferkey","year":"2000","unstructured":"Ferkey DM, Kimelman D (2000) GSK-3: new thoughts on an old enzyme. Dev Biol 225:471\u2013479","journal-title":"Dev Biol"},{"key":"34_CR104","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/nrc2389","volume":"8","author":"A Klaus","year":"2008","unstructured":"Klaus A, Birchmeier W (2008) Wnt signalling and its impact on development and cancer. Nat Rev Cancer 8:387\u2013398","journal-title":"Nat Rev Cancer"},{"key":"34_CR105","doi-asserted-by":"crossref","first-page":"4912","DOI":"10.1093\/emboj\/20.17.4912","volume":"20","author":"A Damalas","year":"2001","unstructured":"Damalas A, Kahan S, Shtutman M, Ben-Ze\u2019ev A, Oren M (2001) Deregulated beta-catenin induces a p53- and ARF-dependent growth arrest and cooperates with Ras in transformation. EMBO J 20:4912\u20134922","journal-title":"EMBO J"},{"key":"34_CR106","doi-asserted-by":"crossref","first-page":"26180","DOI":"10.1074\/jbc.M101188200","volume":"276","author":"CD Mao","year":"2001","unstructured":"Mao CD, Hoang P, DiCorleto PE (2001) Lithium inhibits cell cycle progression and induces stabilization of p53 in bovine aortic endothelial cells. J Biol Chem 276:26180\u201326188","journal-title":"J Biol Chem"},{"key":"34_CR107","doi-asserted-by":"crossref","first-page":"5248","DOI":"10.1073\/pnas.0704242105","volume":"105","author":"S Liu","year":"2008","unstructured":"Liu S, Fang X, Hall H, Yu S, Smith D, Lu Z, Fang D, Liu J, Stephens LC, Woodgett JR, Mills GB (2008) Homozygous deletion of glycogen synthase kinase 3\u03b2 bypasses senescence allowing Ras transformation of primary murine fibroblasts. Proc Natl Acad Sci USA 105:5248\u20135253","journal-title":"Proc Natl Acad Sci USA"},{"key":"34_CR108","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0047-6374(84)90149-0","volume":"28","author":"RL Khandelwal","year":"1984","unstructured":"Khandelwal RL, Enno TL, Narayanan N (1984) Effects of age on glycogen synthase and phosphorylase activities in rat liver. Mech Ageing Dev 28:13\u201322","journal-title":"Mech Ageing Dev"},{"key":"34_CR109","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1093\/geronj\/42.2.168","volume":"42","author":"E Dall\u2019Aglio","year":"1987","unstructured":"Dall\u2019Aglio E, Chang H, Reaven GM, Azhar S (1987) Age-related changes in rat muscle glycogen synthase activity. J Gerontol 42:168\u2013172","journal-title":"J Gerontol"},{"key":"34_CR110","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0167-4943(92)90009-S","volume":"14","author":"A Mysliwski","year":"1992","unstructured":"Mysliwski A, Kmiec Z (1992) Effect of aging on glycogen synthesis in liver of starved-refed rats. Arch Gerontol Geriatr 14:85\u201392","journal-title":"Arch Gerontol Geriatr"},{"key":"34_CR111","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1474-9728.2004.00117.x","volume":"3","author":"JW Zmijewski","year":"2004","unstructured":"Zmijewski JW, Jope RS (2004) Nuclear accumulation of glycogen synthase kinase-3 during replicative senescence of human fibroblasts. Aging Cell 3:309\u2013317","journal-title":"Aging Cell"},{"key":"34_CR112","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.molcel.2007.05.034","volume":"27","author":"X Ye","year":"2007","unstructured":"Ye X, Zerlanko B, Kennedy A, Banumathy G, Zhang R, Adams P (2007) Downregulation of Wnt signaling is a trigger for formation of facultative heterochromatin and onset of cell senescence in primary human cells. Mol Cell 27:183\u2013196","journal-title":"Mol Cell"},{"key":"34_CR113","doi-asserted-by":"crossref","first-page":"27298","DOI":"10.1074\/jbc.M702811200","volume":"282","author":"M Almeida","year":"2007","unstructured":"Almeida M, Han L, Martin-Millan M, O\u2019Brien CA, Manolagas SC (2007) Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting beta-catenin from T cell factor- to forkhead box O-mediated transcription. J Biol Chem 282:27298\u201327305","journal-title":"J Biol Chem"},{"key":"34_CR114","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1126\/science.1109083","volume":"308","author":"MAG Essers","year":"2005","unstructured":"Essers MAG, de Vries-Smits LMM, Barker N, Polderman PE, Burgering BMT, Korswagen HC (2005) Functional interaction between {beta}-catenin and FOXO in oxidative stress signaling. Science 308:1181\u20131184","journal-title":"Science"},{"key":"34_CR115","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1126\/science.1071549","volume":"296","author":"RT Moon","year":"2002","unstructured":"Moon RT, Bowerman B, Boutros M, Perrimon N (2002) The promise and perils of Wnt signaling through beta-catenin. Science 296:1644\u20131646","journal-title":"Science"},{"key":"34_CR116","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/nature01036","volume":"419","author":"GJ Kops","year":"2002","unstructured":"Kops GJ, Dansen TB, Polderman PE, Saarloos I, Wirtz KW, Coffer PJ, Huang TT, Bos JL, Medema RH, Burgering BM (2002) Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature 419:316\u2013321","journal-title":"Nature"},{"key":"34_CR117","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1126\/science.1094637","volume":"303","author":"A Brunet","year":"2004","unstructured":"Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, Tran H, Ross SE, Mostoslavsky R, Cohen HY, Hu LS, Cheng HL, Jedrychowski MP, Gygi SP, Sinclair DA, Alt FW, Greenberg ME (2004) Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303:2011\u20132015","journal-title":"Science"},{"key":"34_CR118","doi-asserted-by":"crossref","first-page":"4802","DOI":"10.1038\/sj.emboj.7600476","volume":"23","author":"MA Essers","year":"2004","unstructured":"Essers MA, Weijzen S, de Vries-Smits AM, Saarloos I, de Ruiter ND, Bos JL, Burgering BM (2004) FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK. EMBO J 23:4802\u20134812","journal-title":"EMBO J"},{"key":"34_CR119","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0925-4439(94)90061-2","volume":"1226","author":"D Boffoli","year":"1994","unstructured":"Boffoli D, Scacco SC, Vergari R, Solarino G, Santacroce G, Papa S (1994) Decline with age of the respiratory chain activity in human skeletal muscle. Biochim Biophys Acta 1226:73\u201382","journal-title":"Biochim Biophys Acta"},{"key":"34_CR120","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/0006-291X(89)92701-0","volume":"165","author":"T-C Yen","year":"1989","unstructured":"Yen T-C, Chen Y-S, King K-L, Yeh S-H, Wei Y-H (1989) Liver mitochondrial respiratory functions decline with age. Biochem Biophys Res Commun 165:994\u20131003","journal-title":"Biochem Biophys Res Commun"},{"key":"34_CR121","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1006\/bbrc.1994.2732","volume":"205","author":"AMS Lezza","year":"1994","unstructured":"Lezza AMS, Boffoli D, Scacco S, Cantatore P, Gadaleta MN (1994) Correlation between mitochondrial DNA 4977-bp deletion and respiratory chain enzyme activities in aging human skeletal muscles. Biochem Biophys Res Commun 205:772\u2013779","journal-title":"Biochem Biophys Res Commun"},{"key":"34_CR122","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nature02517","volume":"429","author":"A Trifunovic","year":"2004","unstructured":"Trifunovic A, Wredenberg A, Falkenberg M, Spelbrink JN, Rovio AT, Bruder CE, Bohlooly-Y M, Gidlof S, Oldfors A, Wibom R, Tornell J, Jacobs HT, Larsson N-G (2004) Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 429:417\u2013423","journal-title":"Nature"},{"key":"34_CR123","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/35041687","volume":"408","author":"T Finkel","year":"2000","unstructured":"Finkel T, Holbrook NJ (2000) Oxidants, oxidative stress and the biology of ageing. Nature 408:239\u2013247","journal-title":"Nature"},{"key":"34_CR124","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1046\/j.1474-9728.2002.00004.x","volume":"1","author":"L Liu","year":"2002","unstructured":"Liu L, Trimarchi JR, Smith PJ, Keefe DL (2002) Mitochondrial dysfunction leads to telomere attrition and genomic instability. Aging Cell 1:40\u201346","journal-title":"Aging Cell"},{"key":"34_CR125","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1046\/j.1474-9728.2003.00040.x","volume":"2","author":"G Saretzki","year":"2003","unstructured":"Saretzki G, Murphy MP, von Zglinicki T (2003) MitoQ counteracts telomere shortening and elongates lifespan of fibroblasts under mild oxidative stress. Aging Cell 2:141\u2013143","journal-title":"Aging Cell"},{"key":"34_CR126","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0014-4827(84)90671-2","volume":"154","author":"S Goldstein","year":"1984","unstructured":"Goldstein S, Moerman EJ, Porter K (1984) High-voltage electron microscopy of human diploid fibroblasts during ageing in vitro: morphometric analysis of mitochondria. Exp Cell Res 154:101\u2013111","journal-title":"Exp Cell Res"},{"key":"34_CR127","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/BF02254978","volume":"9","author":"HC Lee","year":"2002","unstructured":"Lee HC, Yin PH, Chi CW, Wei YH (2002) Increase in mitochondrial mass in human fibroblasts under oxidative stress and during replicative cell senescence. J Biomed Sci 9:517\u2013526","journal-title":"J Biomed Sci"},{"key":"34_CR128","doi-asserted-by":"crossref","first-page":"e110","DOI":"10.1371\/journal.pbio.0050110","volume":"5","author":"JF Passos","year":"2007","unstructured":"Passos JF, Saretzki G, Ahmed S, Nelson G, Richter T, Peters H, Wappler I, Birket MJ, Harold G, Schaeuble K, Birch-Machin MA, Kirkwood TBL, von Zglinicki T (2007) Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence. PLoS Biol 5:e110","journal-title":"PLoS Biol"},{"key":"34_CR129","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S0014-5793(98)01564-6","volume":"441","author":"HC Lee","year":"1998","unstructured":"Lee HC, Lu CY, Fahn HJ, Wei YH (1998) Aging- and smoking-associated alteration in the relative content of mitochondrial DNA in human lung. FEBS Lett 441:292\u2013296","journal-title":"FEBS Lett"},{"key":"34_CR130","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1749-6632.2001.tb05640.x","volume":"928","author":"YH Wei","year":"2001","unstructured":"Wei YH, Lee CF, Lee HC, Ma YS, Wang CW, Lu CY, Pang CY (2001) Increases of mitochondrial mass and mitochondrial genome in association with enhanced oxidative stress in human cells harboring 4, 977 BP-deleted mitochondrial DNA. Ann N Y Acad Sci 928:97\u2013112","journal-title":"Ann N Y Acad Sci"},{"key":"34_CR131","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1006\/bbrc.1998.9181","volume":"249","author":"H Suzuki","year":"1998","unstructured":"Suzuki H, Kumagai T, Goto A, Sugiura T (1998) Increase in intracellular hydrogen peroxide and upregulation of a nuclear respiratory gene evoked by impairment of mitochondrial electron transfer in human cells. Biochem Biophys Res Commun 249:542\u2013545","journal-title":"Biochem Biophys Res Commun"},{"key":"34_CR132","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1006\/bbrc.1999.0580","volume":"258","author":"S Miranda","year":"1999","unstructured":"Miranda S, Foncea R, Guerrero J, Leighton F (1999) Oxidative stress and upregulation of mitochondrial biogenesis genes in mitochondrial DNA-depleted HeLa cells. Biochem Biophys Res Commun 258:44\u201349","journal-title":"Biochem Biophys Res Commun"},{"key":"34_CR133","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1042\/bj3480425","volume":"348","author":"HC Lee","year":"2000","unstructured":"Lee HC, Yin PH, Lu CY, Chi CW, Wei YH (2000) Increase of mitochondria and mitochondrial DNA in response to oxidative stress in human cells. Biochem J 348:425\u2013432","journal-title":"Biochem J"},{"key":"34_CR134","doi-asserted-by":"crossref","first-page":"e2009","DOI":"10.1371\/journal.pone.0002009","volume":"3","author":"X Fu","year":"2008","unstructured":"Fu X, Wan S, Lyu YL, Liu LF, Qi H (2008) Etoposide induces ATM-dependent mitochondrial biogenesis through AMPK activation. PLoS ONE 3:e2009","journal-title":"PLoS ONE"},{"key":"34_CR135","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S0014-5793(01)02628-X","volume":"501","author":"AMS Lezza","year":"2001","unstructured":"Lezza AMS, Pesce V, Cormio A, Fracasso F, Vecchiet J, Felzani G, Cantatore P, Gadaleta MN (2001) Increased expression of mitochondrial transcription factor A and nuclear respiratory factor-1 in skeletal muscle from aged human subjects. FEBS Lett 501:74\u201378","journal-title":"FEBS Lett"},{"key":"34_CR136","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S1567-7249(01)00005-8","volume":"1","author":"DA Bota","year":"2001","unstructured":"Bota DA, Davies KJA (2001) Protein degradation in mitochondria: implications for oxidative stress, aging and disease: a novel etiological classification of mitochondrial proteolytic disorders. Mitochondrion 1:33\u201349","journal-title":"Mitochondrion"},{"key":"34_CR137","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1002\/jcp.20753","volume":"209","author":"YS Yoon","year":"2006","unstructured":"Yoon YS, Yoon DS, Lim IK, Yoon SH, Chung HY, Rojo M, Malka F, Jou MJ, Martinou JC, Yoon G (2006) Formation of elongated giant mitochondria in DFO-induced cellular senescence: involvement of enhanced fusion process through modulation of Fis1. J Cell Physiol 209:468\u2013480","journal-title":"J Cell Physiol"},{"key":"34_CR138","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/sj.emboj.7601963","volume":"27","author":"G Twig","year":"2008","unstructured":"Twig G, Elorza A, Molina AJ, Mohamed H, Wikstrom JD, Walzer G, Stiles L, Haigh SE, Katz S, Las G, Alroy J, Wu M, Py BF, Yuan J, Deeney JT, Corkey BE, Shirihai OS (2008) Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO J 27:433\u2013446","journal-title":"EMBO J"},{"key":"34_CR139","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1471-4159.2008.05604.x","volume":"107","author":"DRCP Miquel Vila","year":"2008","unstructured":"Miquel Vila DRCP (2008) Mitochondrial alterations in Parkinson\u2019s disease: new clues. J Neurochem 107:317\u2013328","journal-title":"J Neurochem"},{"key":"34_CR140","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1083\/jcb.200809125","volume":"183","author":"D Narendra","year":"2008","unstructured":"Narendra D, Tanaka A, Suen D-F, Youle RJ (2008) Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol 183:795\u2013803","journal-title":"J Cell Biol"},{"key":"34_CR141","doi-asserted-by":"crossref","first-page":"31505","DOI":"10.1074\/jbc.M002102200","volume":"275","author":"AM Cuervo","year":"2000","unstructured":"Cuervo AM, Dice JF (2000) Age-related decline in chaperone-mediated autophagy. J Biol Chem 275:31505\u201331513","journal-title":"J Biol Chem"},{"key":"34_CR142","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1196\/annals.1396.020","volume":"1114","author":"E Bergamini","year":"2007","unstructured":"Bergamini E, Cavallini G, Donati A, Gori Z (2007) The role of autophagy in aging: its essential part in the anti-aging mechanism of caloric restriction. Ann N Y Acad Sci 1114:69\u201378","journal-title":"Ann N Y Acad Sci"},{"key":"34_CR143","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1152\/physiol.00013.2008","volume":"23","author":"WL Yen","year":"2008","unstructured":"Yen WL, Klionsky DJ (2008) How to live long and prosper: autophagy, mitochondria, and aging. Physiology 23:248\u2013262","journal-title":"Physiology"},{"key":"34_CR144","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1159\/000213753","volume":"41","author":"A Terman","year":"1995","unstructured":"Terman A (1995) The effect of age on formation and elimination of autophagic vacuoles in mouse hepatocytes. Gerontology 41:319\u2013326","journal-title":"Gerontology"},{"key":"34_CR145","doi-asserted-by":"crossref","first-page":"H1119","DOI":"10.1152\/ajpheart.00713.2007","volume":"294","author":"S Patschan","year":"2008","unstructured":"Patschan S, Chen J, Polotskaia A, Mendelev N, Cheng J, Patschan D, Goligorsky MS (2008) Lipid mediators of autophagy in stress-induced premature senescence of endothelial cells. Am J Physiol Heart Circ Physiol 294:H1119\u2013H1129","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"34_CR146","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1089\/rej.2006.9.408","volume":"9","author":"A Donati","year":"2006","unstructured":"Donati A, Taddei M, Cavallini G, Bergamini E (2006) Stimulation of macroautophagy can rescue older cells from 8-OHdG mtDNA accumulation: a safe and easy way to meet goals in the SENS agenda. Rejuvenation Res 9:408\u2013412","journal-title":"Rejuvenation Res"},{"key":"34_CR147","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1111\/j.1474-9726.2006.00234.x","volume":"5","author":"HT Kang","year":"2006","unstructured":"Kang HT, Lee HI, Hwang ES (2006) Nicotinamide extends replicative lifespan of human cells. Aging Cell 5:423\u2013436","journal-title":"Aging Cell"},{"key":"34_CR148","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.mad.2005.03.002","volume":"126","author":"M Jendrach","year":"2005","unstructured":"Jendrach M, Pohl S, V\u00f6th M, Kowald A, Hammerstein P, Bereiter-Hahn J (2005) Morpho-dynamic changes of mitochondria during ageing of human endothelial cells. Mech Ageing Dev 126:813\u2013821","journal-title":"Mech Ageing Dev"},{"key":"34_CR149","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1006\/excr.2002.5485","volume":"274","author":"AK Balin","year":"2002","unstructured":"Balin AK, Fisher AJ, Anzelone M, Leong I, Allen RG (2002) Effects of establishing cell cultures and cell culture conditions on the proliferative life span of human fibroblasts isolated from different tissues and donors of different ages. Exp Cell Res 274:275\u2013287","journal-title":"Exp Cell Res"},{"key":"34_CR150","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s10522-007-9113-7","volume":"9","author":"D Betts","year":"2008","unstructured":"Betts D, Perrault S, King W (2008) Low oxygen delays fibroblast senescence despite shorter telomeres. Biogerontology 9:19\u201331","journal-title":"Biogerontology"},{"key":"34_CR151","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.exger.2007.08.005","volume":"42","author":"T Richter","year":"2007","unstructured":"Richter T, Zglinicki T (2007) A continuous correlation between oxidative stress and telomere shortening in fibroblasts. Exp Gerontol 42:1039\u20131042","journal-title":"Exp Gerontol"},{"key":"34_CR152","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.ceb.2003.10.015","volume":"15","author":"E Bossy-Wetzel","year":"2003","unstructured":"Bossy-Wetzel E, Barsoum MJ, Godzik A, Schwarzenbacher R, Lipton SA (2003) Mitochondrial fission in apoptosis, neurodegeneration and aging. Curr Opin Cell Biol 15:706\u2013716","journal-title":"Curr Opin Cell Biol"},{"key":"34_CR153","doi-asserted-by":"crossref","first-page":"11521","DOI":"10.1074\/jbc.M607279200","volume":"282","author":"N Taguchi","year":"2007","unstructured":"Taguchi N, Ishihara N, Jofuku A, Oka T, Mihara K (2007) Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission. J Biol Chem 282:11521\u201311529","journal-title":"J Biol Chem"},{"key":"34_CR154","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1038\/90976","volume":"7","author":"K Nakada","year":"2001","unstructured":"Nakada K, Inoue K, Ono T, Isobe K, Ogura A, Goto Y-I, Nonaka I, Hayashi J-I (2001) Inter-mitochondrial complementation: mitochondria-specific system preventing mice from expression of disease phenotypes by mutant mtDNA. Nat Med 7:934\u2013940","journal-title":"Nat Med"},{"key":"34_CR155","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/90116","volume":"28","author":"T Ono","year":"2001","unstructured":"Ono T, Isobe K, Nakada K, Hayashi J-I (2001) Human cells are protected from mitochondrial dysfunction by complementation of DNA products in fused mitochondria. Nat Genet 28:272\u2013275","journal-title":"Nat Genet"},{"key":"34_CR156","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1534\/genetics.103.021287","volume":"167","author":"A Sato","year":"2004","unstructured":"Sato A, Nakada K, Shitara H, Yonekawa H, Hayashi J-I (2004) In vivo interaction between mitochondria carrying mtDNAs from different mouse species. Genetics 167:1855\u20131861","journal-title":"Genetics"},{"key":"34_CR157","first-page":"477","volume":"33","author":"R Solmi","year":"1994","unstructured":"Solmi R, Pallotti F, Rugolo M, Genova ML, Estornell E, Ghetti P, Pugnaloni A, Biagini G, Rizzoli C, Lenaz G (1994) Lack of major mitochondrial bioenergetic changes in cultured skin fibroblasts from aged individuals. Biochem Mol Biol Int 33:477\u2013484","journal-title":"Biochem Mol Biol Int"},{"key":"34_CR158","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1159\/000212035","volume":"21","author":"PD Wilson","year":"1975","unstructured":"Wilson PD, Franks LM (1975) The effect of age on mitochondrial ultrastructure. Gerontologia 21:81\u201394","journal-title":"Gerontologia"},{"key":"34_CR159","first-page":"403","volume":"25","author":"T Sato","year":"1975","unstructured":"Sato T, Tauchi H (1975) The formation of enlarged and giant mitochondria in the aging process of human hepatic cells. Acta Pathol Jpn 25:403\u2013412","journal-title":"Acta Pathol Jpn"},{"key":"34_CR160","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1152\/physrev.1997.77.2.425","volume":"77","author":"T Ozawa","year":"1997","unstructured":"Ozawa T (1997) Genetic and functional changes in mitochondria associated with aging. Physiol Rev 77:425\u2013464","journal-title":"Physiol Rev"},{"key":"34_CR161","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/aja.1001500105","volume":"150","author":"HG Sachs","year":"1977","unstructured":"Sachs HG, Colgan JA, Lazarus ML (1977) Ultrastructure of the aging myocardium: a morphometric approach. Am J Anat 150:63\u201371","journal-title":"Am J Anat"},{"key":"34_CR162","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0925-4439(95)00021-U","volume":"1271","author":"DC Wallace","year":"1995","unstructured":"Wallace DC, Shoffner JM, Trounce I, Brown MD, Ballinger SW, Corral-Debrinski M, Horton T, Jun AS, Lott MT (1995) Mitochondrial DNA mutations in human degenerative diseases and aging. Biochim Biophys Acta 1271:141\u2013151","journal-title":"Biochim Biophys Acta"},{"key":"34_CR163","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1006\/bmme.1997.2647","volume":"62","author":"A Barrientos","year":"1997","unstructured":"Barrientos A, Casademont J, Cardellach F, Ardite E, Estivill X, Urbano-M\u00e1rquez A, Fern\u00e1ndez-Checa JC, Nunes V (1997) Qualitative and quantitative changes in skeletal muscle mtDNA and expression of mitochondrial-encoded genes in the human aging process. Biochem Mol Med 62:165\u2013171","journal-title":"Biochem Mol Med"},{"key":"34_CR164","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S0006-291X(05)80233-5","volume":"176","author":"P Fernandez-Silva","year":"1991","unstructured":"Fernandez-Silva P, Petruzzella V, Fracasso F, Gadaleta MN, Cantatore P (1991) Reduced synthesis of mtRNA in isolated mitochondria of senescent rat brain. Biochem Biophys Res Commun 176:645\u2013653","journal-title":"Biochem Biophys Res Commun"},{"key":"34_CR165","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/S0169-328X(97)00278-7","volume":"52","author":"A Barrientos","year":"1997","unstructured":"Barrientos A, Casademont J, Cardellach F, Estivill X, Urbano-Marquez A, Nunes V (1997) Reduced steady-state levels of mitochondrial RNA and increased mitochondrial DNA amount in human brain with aging. Mol Brain Res 52:284\u2013289","journal-title":"Mol Brain Res"},{"key":"34_CR166","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S0014-5793(98)01564-6","volume":"441","author":"H-C Lee","year":"1998","unstructured":"Lee H-C, Lu C-Y, Fahn H-J, Wei Y-H (1998) Aging- and smoking-associated alteration in the relative content of mitochondrial DNA in human lung. FEBS Lett 441:292\u2013296","journal-title":"FEBS Lett"},{"key":"34_CR167","first-page":"229","volume-title":"Understanding the basis of aging: the roles of mitochondria, free radicals, and antioxidants","author":"UT Brunk","year":"1999","unstructured":"Brunk UT, Terman A (1999) The mitochondrial-lysosomal axis theory of cellular aging. In: Cadenas E, Packer L (eds) Understanding the basis of aging: the roles of mitochondria, free radicals, and antioxidants. Marcel Dekker, New York, pp 229\u2013250"},{"key":"34_CR168","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1046\/j.1432-1033.2002.02869.x","volume":"269","author":"UT Brunk","year":"2002","unstructured":"Brunk UT, Terman A (2002) The mitochondrial-lysosomal axis theory of aging: accumulation of damaged mitochondria as a result of imperfect autophagocytosis. Eur J Biochem 269:1996\u20132002","journal-title":"Eur J Biochem"},{"key":"34_CR169","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1096\/fj.02-1009fje","volume":"17","author":"M Greco","year":"2003","unstructured":"Greco M, Villani G, Mazzucchelli F, Bresolin N, Papa S, Attardi G (2003) Marked aging-related decline in efficiency of oxidative phosphorylation in human skin fibroblasts. FASEB J 17:1706\u20131708","journal-title":"FASEB J"},{"key":"34_CR170","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/j.1365-201X.2004.01371.x","volume":"182","author":"B Drew","year":"2004","unstructured":"Drew B, Leeuwenburgh C (2004) Ageing and subcellular distribution of mitochondria: role of mitochondrial DNA deletions and energy production. Acta Physiol Scand 182:333\u2013341","journal-title":"Acta Physiol Scand"},{"key":"34_CR171","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0027-5107(00)00059-2","volume":"452","author":"ME Lopez","year":"2000","unstructured":"Lopez ME, Van Zeeland NL, Dahl DB, Weindruch R, Aiken JM (2000) Cellular phenotypes of age-associated skeletal muscle mitochondrial abnormalities in rhesus monkeys. Mutat Res 452:123\u2013138","journal-title":"Mutat Res"},{"key":"34_CR172","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0092-8674(03)00401-X","volume":"113","author":"M Narita","year":"2003","unstructured":"Narita M, N\u0169nez S, Heard E, Narita M, Lin AW, Hearn SA, Spector DL, Hannon GJ, Lowe SW (2003) Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell 113:703\u2013716","journal-title":"Cell"},{"key":"34_CR173","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nature03841","volume":"436","author":"M Braig","year":"2005","unstructured":"Braig M, Lee S, Loddenkemper C, Rudolph C, Peters AHFM, Schlegelberger B, Stein H, Dorken B, Jenuwein T, Schmitt CA (2005) Oncogene-induced senescence as an initial barrier in lymphoma development. Nature 436:660\u2013665","journal-title":"Nature"},{"key":"34_CR174","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.devcel.2004.10.019","volume":"8","author":"R Zhang","year":"2005","unstructured":"Zhang R, Poustovoitov MV, Ye X, Santos HA, Chen W, Daganzo SM, Erzberger JP, Serebriiskii IG, Canutescu AA, Dunbrack RL, Pehrson JR, Berger JM, Kaufman PD, Adams PD (2005) Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA. Dev Cell 8:19\u201330","journal-title":"Dev Cell"},{"key":"34_CR175","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1083\/jcb.200604005","volume":"175","author":"R Funayama","year":"2006","unstructured":"Funayama R, Saito M, Tanobe H, Ishikawa F (2006) Loss of linker histone H1 in cellular senescence. J Cell Biol 175:869\u2013880","journal-title":"J Cell Biol"},{"key":"34_CR176","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1128\/MCB.01592-06","volume":"27","author":"X Ye","year":"2007","unstructured":"Ye X, Zerlanko B, Zhang R, Somaiah N, Lipinski M, Salomoni P, Adams PD (2007) Definition of pRB- and p53-dependent and -independent steps in HIRA\/ASF1a-mediated formation of senescence-associated heterochromatin foci. Mol Cell Biol 27:2452\u20132465","journal-title":"Mol Cell Biol"},{"key":"34_CR177","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1128\/MCB.02019-06","volume":"27","author":"R Zhang","year":"2007","unstructured":"Zhang R, Chen W, Adams PD (2007) Molecular dissection of formation of senescence-associated heterochromatin foci. Mol Cell Biol 27:2343\u20132358","journal-title":"Mol Cell Biol"},{"key":"34_CR178","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.cell.2006.05.052","volume":"126","author":"M Narita","year":"2006","unstructured":"Narita M, Narita M, Krizhanovsky V, N\u0169nez S, Chicas A, Hearn SA, Myers MP, Lowe SW (2006) A novel role for high-mobility group A proteins in cellular senescence and heterochromatin formation. Cell 126:503\u2013514","journal-title":"Cell"},{"key":"34_CR179","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1038\/ncb1471","volume":"8","author":"C Denoyelle","year":"2006","unstructured":"Denoyelle C, Abou-Rjaily G, Bezrookove V, Verhaegen M, Johnson TM, Fullen DR, Pointer JN, Gruber SB, Su LD, Nikiforov MA, Kaufman RJ, Bastian BC, Soengas MS (2006) Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway. Nat Cell Biol 8:1053\u20131063","journal-title":"Nat Cell Biol"},{"key":"34_CR180","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/436642a","volume":"436","author":"M Collado","year":"2005","unstructured":"Collado M, Gil J, Efeyan A, Guerra C, Schuhmacher AJ, Barradas M, Benguria A, Zaballos A, Flores JM, Barbacid M, Beach D, Serrano M (2005) Tumour biology: senescence in premalignant tumours. Nature 436:642","journal-title":"Nature"},{"key":"34_CR181","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nature03918","volume":"436","author":"Z Chen","year":"2005","unstructured":"Chen Z, Trotman LC, Shaffer D, Lin H-K, Dotan ZA, Niki M, Koutcher JA, Scher HI, Ludwig T, Gerald W, Cordon-Cardo C, Paolo Pandolfi P (2005) Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature 436:725\u2013730","journal-title":"Nature"},{"key":"34_CR182","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/nature03890","volume":"436","author":"C Michaloglou","year":"2005","unstructured":"Michaloglou C, Vredeveld LCW, Soengas MS, Denoyelle C, Kuilman T, van der Horst CMAM, Majoor DM, Shay JW, Mooi WJ, Peeper DS (2005) BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature 436:720\u2013724","journal-title":"Nature"},{"key":"34_CR183","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1126\/science.1122446","volume":"311","author":"U Herbig","year":"2006","unstructured":"Herbig U, Ferreira M, Condel L, Carey D, Sedivy JM (2006) Cellular senescence in aging primates. Science 311:1257","journal-title":"Science"},{"key":"34_CR184","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/S0960-9822(03)00542-6","volume":"13","author":"H Takai","year":"2003","unstructured":"Takai H, Smogorzewska A, de Lange T (2003) DNA damage foci at dysfunctional telomeres. Curr Biol 13:1549\u20131556","journal-title":"Curr Biol"},{"key":"34_CR185","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1083\/jcb.146.5.905","volume":"146","author":"EP Rogakou","year":"1999","unstructured":"Rogakou EP, Boon C, Redon C, Bonner WM (1999) Megabase chromatin domains involved in DNA double-strand breaks in vivo. J Cell Biol 146:905\u2013916","journal-title":"J Cell Biol"},{"key":"34_CR186","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/nature02118","volume":"426","author":"F d\u2019Adda di Fagagna","year":"2003","unstructured":"d\u2019Adda di Fagagna F, Reaper PM, Clay-Farrace L, Fiegler H, Carr P, von Zglinicki T, Saretzki G, Carter NP, Jackson SP (2003) A DNA damage checkpoint response in telomere-initiated senescence. Nature 426:194\u2013198","journal-title":"Nature"},{"key":"34_CR187","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S1097-2765(04)00256-4","volume":"14","author":"U Herbig","year":"2004","unstructured":"Herbig U, Jobling WA, Chen BPC, Chen DJ, Sedivy JM (2004) Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21CIP1, but not p16INK4a. Mol Cell 14:501\u2013513","journal-title":"Mol Cell"},{"key":"34_CR188","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/ncb1095","volume":"6","author":"OA Sedelnikova","year":"2004","unstructured":"Sedelnikova OA, Horikawa I, Zimonjic DB, Popescu NC, Bonner WM, Barrett JC (2004) Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks. Nat Cell Biol 6:168\u2013170","journal-title":"Nat Cell Biol"},{"key":"34_CR189","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.ceb.2004.03.009","volume":"16","author":"LC Mounkes","year":"2004","unstructured":"Mounkes LC, Stewart CL (2004) Aging and nuclear organization: lamins and progeria. Curr Opin Cell Biol 16:322\u2013327","journal-title":"Curr Opin Cell Biol"},{"key":"34_CR190","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/nm1266","volume":"11","author":"B Liu","year":"2005","unstructured":"Liu B, Wang J, Chan KM, Tjia WM, Deng W, Guan X, Huang JD, Li KM, Chau PY, Chen DJ, Pei D, Pendas AM, Cadinanos J, Lopez-Otin C, Tse HF, Hutchison C, Chen J, Cao Y, Cheah KSE, Tryggvason K, Zhou Z (2005) Genomic instability in laminopathy-based premature aging. Nat Med 11:780\u2013785","journal-title":"Nat Med"},{"key":"34_CR191","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/nm1204","volume":"11","author":"P Scaffidi","year":"2005","unstructured":"Scaffidi P, Misteli T (2005) Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome. Nat Med 11:440\u2013445","journal-title":"Nat Med"},{"key":"34_CR192","doi-asserted-by":"crossref","first-page":"4644","DOI":"10.1242\/jcs.03263","volume":"119","author":"Y Liu","year":"2006","unstructured":"Liu Y, Rusinol A, Sinensky M, Wang Y, Zou Y (2006) DNA damage responses in progeroid syndromes arise from defective maturation of prelamin A. J Cell Sci 119:4644\u20134649","journal-title":"J Cell Sci"},{"key":"34_CR193","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1126\/science.1127168","volume":"312","author":"P Scaffidi","year":"2006","unstructured":"Scaffidi P, Misteli T (2006) Lamin A-dependent nuclear defects in human aging. Science 312:1059\u20131063","journal-title":"Science"},{"key":"34_CR194","doi-asserted-by":"crossref","first-page":"10230","DOI":"10.1073\/pnas.0604392103","volume":"103","author":"WC Hallows","year":"2006","unstructured":"Hallows WC, Lee S, Denu JM (2006) Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases. Proc Natl Acad Sci USA 103:10230\u201310235","journal-title":"Proc Natl Acad Sci USA"},{"key":"34_CR195","doi-asserted-by":"crossref","first-page":"10224","DOI":"10.1073\/pnas.0603968103","volume":"103","author":"B Schwer","year":"2006","unstructured":"Schwer B, Bunkenborg J, Verdin RO, Andersen JS, Verdin E (2006) Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2. Proc Natl Acad Sci USA 103:10224\u201310229","journal-title":"Proc Natl Acad Sci USA"},{"key":"34_CR196","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.jmb.2008.07.048","volume":"382","author":"C Schlicker","year":"2008","unstructured":"Schlicker C, Gertz M, Papatheodorou P, Kachholz B, Becker CFW, Steegborn C (2008) Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5. J Mol Biol 382:790\u2013801","journal-title":"J Mol Biol"},{"key":"34_CR197","doi-asserted-by":"crossref","first-page":"8807","DOI":"10.1128\/MCB.01636-07","volume":"27","author":"DB Lombard","year":"2007","unstructured":"Lombard DB, Alt FW, Cheng H-L, Bunkenborg J, Streeper RS, Mostoslavsky R, Kim J, Yancopoulos G, Valenzuela D, Murphy A, Yang Y, Chen Y, Hirschey MD, Bronson RT, Haigis M, Guarente LP, Farese RV Jr, Weissman S, Verdin E, Schwer B (2007) Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol 27:8807\u20138814","journal-title":"Mol Cell Biol"},{"key":"34_CR198","doi-asserted-by":"crossref","first-page":"291","DOI":"10.7150\/ijbs.4.291","volume":"4","author":"KM Jacobs","year":"2008","unstructured":"Jacobs KM, Pennington JD, Bisht KS, Aykin-Burns N, Kim HS, Mishra M, Sun L, Nguyen P, Ahn BH, Leclerc J, Deng CX, Spitz DR, Gius D (2008) SIRT3 interacts with the daf-16 homolog FOXO3a in the mitochondria, as well as increases FOXO3a dependent gene expression. Int J Biol Sci 4:291\u2013299","journal-title":"Int J Biol Sci"},{"key":"34_CR199","doi-asserted-by":"crossref","first-page":"3355","DOI":"10.4161\/cc.7.21.6919","volume":"7","author":"ZN Demidenko","year":"2008","unstructured":"Demidenko ZN, Blagosklonny MV (2008) Growth stimulation leads to cellular senescence when the cell cycle is blocked. Cell Cycle 7:3355\u20133361","journal-title":"Cell Cycle"},{"key":"34_CR200","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1007\/s11055-008-9066-6","volume":"38","author":"N Korsakova","year":"2008","unstructured":"Korsakova N, Sergeeva V, Petrov S (2008) Immunohistochemical analysis of lens cells on formation of different types of age-related cataract in humans. Neurosci Behav Physiol 38:887\u2013890","journal-title":"Neurosci Behav Physiol"},{"key":"34_CR201","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0047-6374(97)00129-2","volume":"100","author":"A Terman","year":"1998","unstructured":"Terman A, Brunk UT (1998) On the degradability and exocytosis of ceroid\/lipofuscin in cultured rat cardiac myocytes. Mech Ageing Dev 100:145\u2013156","journal-title":"Mech Ageing Dev"},{"key":"34_CR202","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0921-8734(95)00021-W","volume":"338","author":"B Kadenbach","year":"1995","unstructured":"Kadenbach B, Munscher C, Frank V, Muller-Hocker J, Napiwotzki J (1995) Human aging is associated with stochastic somatic mutations of mitochondrial DNA. Mutat Res 338:161\u2013172","journal-title":"Mutat Res"},{"key":"34_CR203","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.mad.2004.11.008","volume":"126","author":"YS Song","year":"2005","unstructured":"Song YS, Lee BY, Hwang ES (2005) Dinstinct ROS and biochemical profiles in cells undergoing DNA damage-induced senescence and apoptosis. Mech Ageing Dev 126:580\u2013590","journal-title":"Mech Ageing Dev"}],"container-title":["Cellular and Molecular Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-009-0034-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00018-009-0034-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-009-0034-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T20:53:15Z","timestamp":1633639995000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00018-009-0034-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5,7]]},"references-count":203,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2009,8]]}},"alternative-id":["34"],"URL":"https:\/\/doi.org\/10.1007\/s00018-009-0034-2","relation":{},"ISSN":["1420-682X","1420-9071"],"issn-type":[{"value":"1420-682X","type":"print"},{"value":"1420-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5,7]]}}}