{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T22:58:08Z","timestamp":1785193088643,"version":"3.55.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"16","license":[{"start":{"date-parts":[[2010,4,8]],"date-time":"2010-04-08T00:00:00Z","timestamp":1270684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell. Mol. Life Sci."],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1007\/s00018-010-0360-4","type":"journal-article","created":{"date-parts":[[2010,4,7]],"date-time":"2010-04-07T17:50:41Z","timestamp":1270662641000},"page":"2815-2824","source":"Crossref","is-referenced-by-count":7,"title":["Depletion of calcium stores contributes to progesterone-induced attenuation of calcium signaling of G protein-coupled receptors"],"prefix":"10.1007","volume":"67","author":[{"given":"Katja","family":"Gehrig-Burger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jirina","family":"Slaninova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Gimpl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,4,8]]},"reference":[{"key":"360_CR1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0301-2115(02)00422-0","volume":"108","author":"S Astle","year":"2003","unstructured":"Astle S, Slater DM, Thornton S (2003) The involvement of progesterone in the onset of human labour. Eur J Obstet Gynecol Reprod Biol 108:177\u2013181","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"360_CR2","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0003-9861(80)90333-1","volume":"200","author":"ER Simpson","year":"1980","unstructured":"Simpson ER, Burkhart MF (1980) Acyl CoA:cholesterol acyl transferase activity in human placental microsomes: inhibition by progesterone. Arch Biochem Biophys 200:79\u201385","journal-title":"Arch Biochem Biophys"},{"key":"360_CR3","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.semcdb.2007.05.003","volume":"18","author":"S Mesiano","year":"2007","unstructured":"Mesiano S, Welsh TN (2007) Steroid hormone control of myometrial contractility and parturition. Semin Cell Dev Biol 18:321\u2013331","journal-title":"Semin Cell Dev Biol"},{"key":"360_CR4","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1677\/joe.0.1310427","volume":"131","author":"MD Majewska","year":"1991","unstructured":"Majewska MD, Vaupel DB (1991) Steroid control of uterine motility via gamma-aminobutyric acidA receptors in the rabbit: a novel mechanism? J Endocrinol 131:427\u2013434","journal-title":"J Endocrinol"},{"key":"360_CR5","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1095\/biolreprod45.2.266","volume":"45","author":"CD Putnam","year":"1991","unstructured":"Putnam CD, Brann DW, Kolbeck RC, Mahesh VB (1991) Inhibition of uterine contractility by progesterone and progesterone metabolites: mediation by progesterone and gamma amino butyric acidA receptor systems. Biol Reprod 45:266\u2013272","journal-title":"Biol Reprod"},{"key":"360_CR6","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0006-291X(84)80327-7","volume":"125","author":"SL Erdo","year":"1984","unstructured":"Erdo SL (1984) Identification of GABA receptor binding sites in rat and rabbit uterus. Biochem Biophys Res Commun 125:18\u201324","journal-title":"Biochem Biophys Res Commun"},{"key":"360_CR7","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1016\/0024-3205(89)90346-9","volume":"44","author":"SL Erdo","year":"1989","unstructured":"Erdo SL, Villanyi P, Laszlo A (1989) Gestational changes of GABA levels and GABA binding in the human uterus. Life Sci 44:2009\u20132014","journal-title":"Life Sci"},{"key":"360_CR8","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/0024-3205(96)00034-3","volume":"58","author":"M Perusquia","year":"1996","unstructured":"Perusquia M, Villalon CM (1996) The relaxant effect of sex steroids in rat myometrium is independent of the gamma-amino butyric acid system. Life Sci 58:913\u2013926","journal-title":"Life Sci"},{"key":"360_CR9","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0306-3623(94)90029-9","volume":"25","author":"R Cabral","year":"1994","unstructured":"Cabral R, Gutierrez M, Fernandez AI, Cantabrana B, Hidalgo A (1994) Progesterone and pregnanolone derivatives relaxing effect on smooth muscle. Gen Pharmacol 25:173\u2013178","journal-title":"Gen Pharmacol"},{"key":"360_CR10","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/33176","volume":"392","author":"E Grazzini","year":"1998","unstructured":"Grazzini E, Guillon G, Mouillac B, Zingg HH (1998) Inhibition of oxytocin receptor function by direct binding of progesterone. Nature 392:509\u2013512","journal-title":"Nature"},{"key":"360_CR11","first-page":"589","volume":"110","author":"S Astle","year":"2003","unstructured":"Astle S, Khan RN, Thornton S (2003) The effects of a progesterone metabolite, 5 beta-dihydroprogesterone, on oxytocin receptor binding in human myometrial membranes. BJOG 110:589\u2013592","journal-title":"BJOG"},{"key":"360_CR12","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0014-5793(99)01668-3","volume":"464","author":"K Burger","year":"1999","unstructured":"Burger K, Fahrenholz F, Gimpl G (1999) Non-genomic effects of progesterone on the signaling function of G protein-coupled receptors. FEBS Lett 464:25\u201329","journal-title":"FEBS Lett"},{"key":"360_CR13","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.mce.2008.02.012","volume":"287","author":"L Zhang","year":"2008","unstructured":"Zhang L, Kanda Y, Roberts DJ, Ecker JL, Losel R, Wehling M, Peluso JJ, Pru JK (2008) Expression of progesterone receptor membrane component 1 and its partner serpine 1 mRNA binding protein in uterine and placental tissues of the mouse and human. Mol Cell Endocrinol 287:81\u201389","journal-title":"Mol Cell Endocrinol"},{"key":"360_CR14","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.cbpc.2008.05.019","volume":"148","author":"Y Zhu","year":"2008","unstructured":"Zhu Y, Hanna RN, Schaaf MJ, Spaink HP, Thomas P (2008) Candidates for membrane progestin receptors\u2014past approaches and future challenges. Comp Biochem Physiol C Toxicol Pharmacol 148:381\u2013389","journal-title":"Comp Biochem Physiol C Toxicol Pharmacol"},{"key":"360_CR15","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1677\/joe.1.06242","volume":"187","author":"MS Fernandes","year":"2005","unstructured":"Fernandes MS, Pierron V, Michalovich D, Astle S, Thornton S, Peltoketo H, Lam EW, Gellersen B, Huhtaniemi I, Allen J, Brosens JJ (2005) Regulated expression of putative membrane progestin receptor homologues in human endometrium and gestational tissues. J Endocrinol 187:89\u2013101","journal-title":"J Endocrinol"},{"key":"360_CR16","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1210\/me.2005-0243","volume":"20","author":"E Karteris","year":"2006","unstructured":"Karteris E, Zervou S, Pang Y, Dong J, Hillhouse EW, Randeva HS, Thomas P (2006) Progesterone signaling in human myometrium through two novel membrane G protein-coupled receptors: potential role in functional progesterone withdrawal at term. Mol Endocrinol 20:1519\u20131534","journal-title":"Mol Endocrinol"},{"key":"360_CR17","doi-asserted-by":"crossref","first-page":"3146","DOI":"10.1210\/me.2006-0129","volume":"20","author":"T Krietsch","year":"2006","unstructured":"Krietsch T, Fernandes MS, Kero J, Losel R, Heyens M, Lam EW, Huhtaniemi I, Brosens JJ, Gellersen B (2006) Human homologs of the putative G protein-coupled membrane progestin receptors (mPRalpha, beta, and gamma) localize to the endoplasmic reticulum and are not activated by progesterone. Mol Endocrinol 20:3146\u20133164","journal-title":"Mol Endocrinol"},{"key":"360_CR18","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1095\/biolreprod54.2.355","volume":"54","author":"KM Battye","year":"1996","unstructured":"Battye KM, Evans G, O\u2019Neill C (1996) Ovine endometrium synthesizes and releases platelet-activating factor, which can cause the release of prostaglandin F2 alpha by the uterus in situ. Biol Reprod 54:355\u2013363","journal-title":"Biol Reprod"},{"key":"360_CR19","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/S0095-5108(18)30265-3","volume":"22","author":"WF O\u2019Brien","year":"1995","unstructured":"O\u2019Brien WF (1995) The role of prostaglandins in labor and delivery. Clin Perinatol 22:973\u2013984","journal-title":"Clin Perinatol"},{"key":"360_CR20","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1095\/biolreprod55.2.427","volume":"55","author":"M Monga","year":"1996","unstructured":"Monga M, Ku CY, Dodge K, Sanborn BM (1996) Oxytocin-stimulated responses in a pregnant human immortalized myometrial cell line. Biol Reprod 55:427\u2013432","journal-title":"Biol Reprod"},{"key":"360_CR21","first-page":"328","volume":"3","author":"P Holton","year":"1948","unstructured":"Holton P (1948) A modification of the method of Dale and Laidlaw for standardization of posterior pituitary extract. Br J Pharmacol 3:328\u2013334","journal-title":"Br J Pharmacol"},{"key":"360_CR22","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1210\/endo-66-3-451","volume":"6","author":"RA Munsick","year":"1960","unstructured":"Munsick RA (1960) Effect of magnesium ion on the response of the rat uterus to neurohypophysial hormones and analogues. Endocrinology 6:451\u2013457","journal-title":"Endocrinology"},{"key":"360_CR23","first-page":"877","volume":"83","author":"M Luconi","year":"1998","unstructured":"Luconi M, Bonaccorsi L, Maggi M, Pecchioli P, Krausz C, Forti G, Baldi E (1998) Identification and characterization of functional nongenomic progesterone receptors on human sperm membrane. J Clin Endocrinol Metab 83:877\u2013885","journal-title":"J Clin Endocrinol Metab"},{"key":"360_CR24","first-page":"705","volume":"255","author":"S Marc","year":"1988","unstructured":"Marc S, Leiber D, Harbon S (1988) Fluoroaluminates mimic muscarinic- and oxytocin-receptor-mediated generation of inositol phosphates and contraction in the intact guinea-pig myometrium. Role for a pertussis\/cholera-toxin-insensitive G protein. Biochem J 255:705\u2013713","journal-title":"Biochem J"},{"key":"360_CR25","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.ceca.2005.06.018","volume":"38","author":"S Wray","year":"2005","unstructured":"Wray S, Burdyga T, Noble K (2005) Calcium signalling in smooth muscle. Cell Calcium 38:397\u2013407","journal-title":"Cell Calcium"},{"key":"360_CR26","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1530\/ror.0.0030196","volume":"3","author":"BM Sanborn","year":"1998","unstructured":"Sanborn BM, Yue C, Wang W, Dodge KL (1998) G protein signalling pathways in myometrium: affecting the balance between contraction and relaxation. Rev Reprod 3:196\u2013205","journal-title":"Rev Reprod"},{"key":"360_CR27","doi-asserted-by":"crossref","first-page":"5999","DOI":"10.1210\/endo.140.12.7304","volume":"140","author":"E Falkenstein","year":"1999","unstructured":"Falkenstein E, Heck M, Gerdes D, Grube D, Christ M, Weigel M, Buddhikot M, Meizel S, Wehling M (1999) Specific progesterone binding to a membrane protein and related nongenomic effects on Ca2+-fluxes in sperm. Endocrinology 140:5999\u20136002","journal-title":"Endocrinology"},{"key":"360_CR28","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1083\/jcb.200210057","volume":"161","author":"K Fukami","year":"2003","unstructured":"Fukami K, Yoshida M, Inoue T, Kurokawa M, Fissore RA, Yoshida N, Mikoshiba K, Takenawa T (2003) Phospholipase Cdelta4 is required for Ca2+ mobilization essential for acrosome reaction in sperm. J Cell Biol 161:79\u201388","journal-title":"J Cell Biol"},{"key":"360_CR29","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0003-9861(02)00587-8","volume":"408","author":"MT Gonzalez-Martinez","year":"2002","unstructured":"Gonzalez-Martinez MT, Bonilla-Hernandez MA, Guzman-Grenfell AM (2002) Stimulation of voltage-dependent calcium channels during capacitation and by progesterone in human sperm. Arch Biochem Biophys 408:205\u2013210","journal-title":"Arch Biochem Biophys"},{"key":"360_CR30","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.steroids.2004.05.013","volume":"69","author":"M Luconi","year":"2004","unstructured":"Luconi M, Francavilla F, Porazzi I, Macerola B, Forti G, Baldi E (2004) Human spermatozoa as a model for studying membrane receptors mediating rapid nongenomic effects of progesterone and estrogens. Steroids 69:553\u2013559","journal-title":"Steroids"},{"key":"360_CR31","first-page":"571","volume":"44","author":"E Falkenstein","year":"1998","unstructured":"Falkenstein E, Schmieding K, Lange A, Meyer C, Gerdes D, Welsch U, Wehling M (1998) Localization of a putative progesterone membrane binding protein in porcine hepatocytes. Cell Mol Biol Noisy le grand 44:571\u2013578","journal-title":"Cell Mol Biol Noisy le grand"},{"key":"360_CR32","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0165-6147(98)01184-5","volume":"19","author":"M Treiman","year":"1998","unstructured":"Treiman M, Caspersen C, Christensen SB (1998) A tool coming of age: thapsigargin as an inhibitor of sarco-endoplasmic reticulum Ca2+-ATPases. Trends Pharmacol Sci 19:131\u2013135","journal-title":"Trends Pharmacol Sci"},{"key":"360_CR33","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/0039-128X(79)90131-4","volume":"34","author":"C Kubli-Garfias","year":"1979","unstructured":"Kubli-Garfias C, Medrano-Conde L, Beyer C, Bondani A (1979) In vitro inhibition of rat uterine contractility induced by 5 alpha and 5 beta progestins. Steroids 34:609\u2013617","journal-title":"Steroids"},{"key":"360_CR34","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/978-1-4615-0123-7_6","volume":"513","author":"RJ Sayer","year":"2002","unstructured":"Sayer RJ (2002) Intracellular Ca2+ handling. Adv Exp Med Biol 513:183\u2013196","journal-title":"Adv Exp Med Biol"},{"key":"360_CR35","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.ceca.2004.03.002","volume":"36","author":"A Gamberucci","year":"2004","unstructured":"Gamberucci A, Giunti R, Benedetti A (2004) Progesterone inhibits capacitative Ca2+ entry in Jurkat T lymphocytes by a membrane delimited mechanism, independently of plasma membrane depolarization. Cell Calcium 36:175\u2013180","journal-title":"Cell Calcium"},{"key":"360_CR36","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1677\/joe.0.0730115","volume":"73","author":"IA Swanston","year":"1977","unstructured":"Swanston IA, McNatty KP, Baird DT (1977) Concentration of prostaglandin F2alpha and steroids in the human corpus luteum. J Endocrinol 73:115\u2013122","journal-title":"J Endocrinol"},{"key":"360_CR37","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.ajog.2008.06.085","volume":"199","author":"NK Ruddock","year":"2008","unstructured":"Ruddock NK, Shi SQ, Jain S, Moore G, Hankins GD, Romero R, Garfield RE (2008) Progesterone, but not 17-alpha-hydroxyprogesterone caproate, inhibits human myometrial contractions. Am J Obstet Gynecol 199:391\u2013397","journal-title":"Am J Obstet Gynecol"},{"key":"360_CR38","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1016\/0024-3205(90)90183-R","volume":"47","author":"M Perusquia","year":"1990","unstructured":"Perusquia M, Garcia YE, Ibanez R, Kubli GC (1990) Non-genomic mechanism of action of delta-4 and 5-reduced androgens and progestins on the contractility of the isolated rat myometrium. Life Sci 47:1547\u20131553","journal-title":"Life Sci"},{"key":"360_CR39","doi-asserted-by":"crossref","first-page":"4151","DOI":"10.1210\/en.2006-0002","volume":"147","author":"RL Ashley","year":"2006","unstructured":"Ashley RL, Clay CM, Farmerie TA, Niswender GD, Nett TM (2006) Cloning and characterization of an ovine intracellular seven transmembrane receptor for progesterone that mediates calcium mobilization. Endocrinology 147:4151\u20134159","journal-title":"Endocrinology"}],"container-title":["Cellular and Molecular Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-010-0360-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00018-010-0360-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-010-0360-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T15:32:25Z","timestamp":1558539145000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00018-010-0360-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4,8]]},"references-count":39,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["360"],"URL":"https:\/\/doi.org\/10.1007\/s00018-010-0360-4","relation":{},"ISSN":["1420-682X","1420-9071"],"issn-type":[{"value":"1420-682X","type":"print"},{"value":"1420-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,4,8]]}}}