{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T08:30:46Z","timestamp":1793089846166,"version":"4.5.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"18","license":[{"start":{"date-parts":[[2011,2,3]],"date-time":"2011-02-03T00:00:00Z","timestamp":1296691200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell. Mol. Life Sci."],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.1007\/s00018-010-0618-x","type":"journal-article","created":{"date-parts":[[2011,2,2]],"date-time":"2011-02-02T08:56:06Z","timestamp":1296636966000},"page":"3121-3131","source":"Crossref","is-referenced-by-count":84,"title":["The structure of the Klf4 DNA-binding domain links to self-renewal and macrophage differentiation"],"prefix":"10.1007","volume":"68","author":[{"given":"Anja","family":"Schuetz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Nana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Rose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Zocher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja","family":"Milanovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Koenigsmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosel","family":"Blasig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udo","family":"Heinemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Carstanjen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,2,3]]},"reference":[{"key":"618_CR1","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1093\/nar\/26.3.796","volume":"26","author":"JM Shields","year":"1998","unstructured":"Shields JM, Yang VW (1998) Identification of the DNA sequence that interacts with the gut-enriched Kr\u00fcppel-like factor. Nucleic Acids Res 26:796\u2013802","journal-title":"Nucleic Acids Res"},{"key":"618_CR2","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1016\/j.biocel.2007.07.018","volume":"40","author":"R Pearson","year":"2008","unstructured":"Pearson R, Fleetwood J, Eaton S, Crossley M, Bao S (2008) Kr\u00fcppel-like transcription factors: a functional family. Int J Biochem Cell Biol 40:1996\u20132001","journal-title":"Int J Biochem Cell Biol"},{"key":"618_CR3","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.ygeno.2005.01.005","volume":"85","author":"G Suske","year":"2005","unstructured":"Suske G, Bruford E, Philipsen S (2005) Mammalian SP\/KLF transcription factors: bring in the family. Genomics 85:551\u2013556","journal-title":"Genomics"},{"key":"618_CR4","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1016\/j.ejca.2005.08.006","volume":"41","author":"S Safe","year":"2005","unstructured":"Safe S, Abdelrahim M (2005) Sp transcription factor family and its role in cancer. Eur J Cancer 41:2438\u20132448","journal-title":"Eur J Cancer"},{"key":"618_CR5","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/gb-2003-4-2-206","volume":"4","author":"J Kaczynski","year":"2003","unstructured":"Kaczynski J, Cook T, Urrutia R (2003) Sp1- and Kr\u00fcppel-like transcription factors. Genome Biol 4:206","journal-title":"Genome Biol"},{"key":"618_CR6","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/375316a0","volume":"375","author":"B Nuez","year":"1995","unstructured":"Nuez B, Michalovich D, Bygrave A, Ploemacher R, Grosveld F (1995) Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene. Nature 375:316\u2013318","journal-title":"Nature"},{"key":"618_CR7","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/375318a0","volume":"375","author":"AC Perkins","year":"1995","unstructured":"Perkins AC, Sharpe AH, Orkin SH (1995) Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF. Nature 375:318\u2013322","journal-title":"Nature"},{"key":"618_CR8","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1126\/science.277.5334.1986","volume":"277","author":"CT Kuo","year":"1997","unstructured":"Kuo CT, Veselits ML, Leiden JM (1997) LKLF: a transcriptional regulator of single-positive T cell quiescence and survival. Science 277:1986\u20131990","journal-title":"Science"},{"key":"618_CR9","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/nature04882","volume":"442","author":"CM Carlson","year":"2006","unstructured":"Carlson CM, Endrizzi BT, Wu J, Ding X, Weinreich MA, Walsh ER, Wani MA, Lingrel JB, Hogquist KA, Jameson SC (2006) Kr\u00fcppel-like factor 2 regulates thymocyte and T-cell migration. Nature 442:299\u2013302","journal-title":"Nature"},{"key":"618_CR10","doi-asserted-by":"crossref","first-page":"5645","DOI":"10.4049\/jimmunol.180.8.5645","volume":"180","author":"JK Alder","year":"2008","unstructured":"Alder JK, Georgantas RW 3rd, Hildreth RL, Kaplan IM, Morisot S, Yu X, McDevitt M, Civin CI (2008) Kr\u00fcppel-like factor 4 is essential for inflammatory monocyte differentiation in vivo. J Immunol 180:5645\u20135652","journal-title":"J Immunol"},{"key":"618_CR11","doi-asserted-by":"crossref","first-page":"4138","DOI":"10.1038\/sj.emboj.7601824","volume":"26","author":"MW Feinberg","year":"2007","unstructured":"Feinberg MW, Wara AK, Cao Z, Lebedeva MA, Rosenbauer F, Iwasaki H, Hirai H, Katz JP, Haspel RL, Gray S, Akashi K, Segre J, Kaestner KH, Tenen DG, Jain MK (2007) The Kr\u00fcppel-like factor KLF4 is a critical regulator of monocyte differentiation. EMBO J 26:4138\u20134148","journal-title":"EMBO J"},{"key":"618_CR12","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.cell.2007.11.020","volume":"131","author":"H Zaehres","year":"2007","unstructured":"Zaehres H, Scholer HR (2007) Induction of pluripotency: from mouse to human. Cell 131:834\u2013835","journal-title":"Cell"},{"key":"618_CR13","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1074\/jbc.273.2.1026","volume":"273","author":"SF Yet","year":"1998","unstructured":"Yet SF, McA\u2019Nulty MM, Folta SC, Yen HW, Yoshizumi M, Hsieh CM, Layne MD, Chin MT, Wang H, Perrella MA, Jain MK, Lee ME (1998) Human EZF, a Kr\u00fcppel-like zinc finger protein, is expressed in vascular endothelial cells and contains transcriptional activation and repression domains. J Biol Chem 273:1026\u20131031","journal-title":"J Biol Chem"},{"key":"618_CR14","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1126\/science.2028256","volume":"252","author":"NP Pavletich","year":"1991","unstructured":"Pavletich NP, Pabo CO (1991) Zinc finger-DNA recognition: crystal structure of a Zif268-DNA complex at 2.1\u00a0\u00c5. Science 252:809\u2013817","journal-title":"Science"},{"key":"618_CR15","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/j.jmb.2007.07.017","volume":"372","author":"R Stoll","year":"2007","unstructured":"Stoll R, Lee BM, Debler EW, Laity JH, Wilson IA, Dyson HJ, Wright PE (2007) Structure of the Wilms tumor suppressor protein zinc finger domain bound to DNA. J Mol Biol 372:1227\u20131245","journal-title":"J Mol Biol"},{"key":"618_CR16","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1126\/science.8378770","volume":"261","author":"NP Pavletich","year":"1993","unstructured":"Pavletich NP, Pabo CO (1993) Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers. Science 261:1701\u20131707","journal-title":"Science"},{"key":"618_CR17","doi-asserted-by":"crossref","first-page":"2938","DOI":"10.1073\/pnas.95.6.2938","volume":"95","author":"RT Nolte","year":"1998","unstructured":"Nolte RT, Conlin RM, Harrison SC, Brown RS (1998) Differing roles for zinc fingers in DNA recognition: structure of a six-finger transcription factor IIIA complex. Proc Natl Acad Sci USA 95:2938\u20132943","journal-title":"Proc Natl Acad Sci USA"},{"key":"618_CR18","doi-asserted-by":"crossref","first-page":"16027","DOI":"10.1021\/bi048438p","volume":"43","author":"S Oka","year":"2004","unstructured":"Oka S, Shiraishi Y, Yoshida T, Ohkubo T, Sugiura Y, Kobayashi Y (2004) NMR structure of transcription factor Sp1 DNA binding domain. Biochemistry 43:16027\u201316035","journal-title":"Biochemistry"},{"key":"618_CR19","doi-asserted-by":"crossref","first-page":"28011","DOI":"10.1074\/jbc.M211146200","volume":"278","author":"RJ Simpson","year":"2003","unstructured":"Simpson RJ, Cram ED, Czolij R, Matthews JM, Crossley M, Mackay JP (2003) CCHX zinc finger derivatives retain the ability to bind Zn(II) and mediate protein\u2013DNA interactions. J Biol Chem 278:28011\u201328018","journal-title":"J Biol Chem"},{"key":"618_CR20","doi-asserted-by":"crossref","first-page":"e43","DOI":"10.1093\/nar\/gkm067","volume":"35","author":"C Scheich","year":"2007","unstructured":"Scheich C, K\u00fcmmel D, Soumailakakis D, Heinemann U, B\u00fcssow K (2007) Vectors for co-expression of an unrestricted number of proteins. Nucleic Acids Res 35:e43","journal-title":"Nucleic Acids Res"},{"key":"618_CR21","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1021\/ar010129t","volume":"36","author":"U Heinemann","year":"2003","unstructured":"Heinemann U, B\u00fcssow K, Mueller U, Umbach P (2003) Facilities and methods for the high-throughput crystal structural analysis of human proteins. Acc Chem Res 36:157\u2013163","journal-title":"Acc Chem Res"},{"key":"618_CR22","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1107\/S0907444902011678","volume":"58","author":"TR Schneider","year":"2002","unstructured":"Schneider TR, Sheldrick GM (2002) Substructure solution with SHELXD. Acta Crystallogr D 58:1772\u20131779","journal-title":"Acta Crystallogr D"},{"key":"618_CR23","first-page":"215","volume":"364","author":"C Vonrhein","year":"2007","unstructured":"Vonrhein C, Blanc E, Roversi P, Bricogne G (2007) Automated structure solution with autoSHARP. Methods Mol Biol 364:215\u2013230","journal-title":"Methods Mol Biol"},{"key":"618_CR24","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/8263","volume":"6","author":"A Perrakis","year":"1999","unstructured":"Perrakis A, Morris R, Lamzin VS (1999) Automated protein model building combined with iterative structure refinement. Nat Struct Biol 6:458\u2013463","journal-title":"Nat Struct Biol"},{"key":"618_CR25","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1107\/S0907444904019158","volume":"60","author":"P Emsley","year":"2004","unstructured":"Emsley P, Cowtan K (2004) Coot: model-building tools for molecular graphics. Acta Crystallogr D 60:2126\u20132132","journal-title":"Acta Crystallogr D"},{"key":"618_CR26","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1107\/S0907444996012255","volume":"53","author":"GN Murshudov","year":"1997","unstructured":"Murshudov GN, Vagin AA, Dodson EJ (1997) Refinement of macromolecular structures by the maximum-likelihood method. Acta Crystallogr D 53:240\u2013255","journal-title":"Acta Crystallogr D"},{"key":"618_CR27","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1107\/S0907444905001617","volume":"61","author":"AJ McCoy","year":"2005","unstructured":"McCoy AJ, Grosse-Kunstleve RW, Storoni LC, Read RJ (2005) Likelihood-enhanced fast translation functions. Acta Crystallogr D 61:458\u2013464","journal-title":"Acta Crystallogr D"},{"key":"618_CR28","unstructured":"DeLano WL (2010) The PyMOL molecular graphics system. DeLano Scientific, San Carlos. http:\/\/www.pymol.org"},{"key":"618_CR29","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1006\/bbrc.1997.7124","volume":"237","author":"R Feil","year":"1997","unstructured":"Feil R, Wagner J, Metzger D, Chambon P (1997) Regulation of Cre recombinase activity by mutated estrogen receptor ligand-binding domains. Biochem Biophys Res Commun 237:752\u2013757","journal-title":"Biochem Biophys Res Commun"},{"key":"618_CR30","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1107\/S0907444904026460","volume":"60","author":"E Krissinel","year":"2004","unstructured":"Krissinel E, Henrick K (2004) Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions. Acta Crystallogr D 60:2256\u20132268","journal-title":"Acta Crystallogr D"},{"key":"618_CR31","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/S0969-2126(96)00125-6","volume":"4","author":"M Elrod-Erickson","year":"1996","unstructured":"Elrod-Erickson M, Rould MA, Nekludova L, Pabo CO (1996) Zif268 protein-DNA complex refined at 1.6\u00a0\u00c5: a model system for understanding zinc finger\u2013DNA interactions. Structure\u00a04:1171\u20131180","journal-title":"Structure"},{"key":"618_CR32","doi-asserted-by":"crossref","first-page":"13577","DOI":"10.1073\/pnas.93.24.13577","volume":"93","author":"HB Houbaviy","year":"1996","unstructured":"Houbaviy HB, Usheva A, Shenk T, Burley SK (1996) Cocrystal structure of YY1 bound to the adeno-associated virus P5 initiator. Proc Natl Acad Sci USA 93:13577\u201313582","journal-title":"Proc Natl Acad Sci USA"},{"key":"618_CR33","doi-asserted-by":"crossref","first-page":"15151","DOI":"10.1073\/pnas.1004996107","volume":"107","author":"M Siatecka","year":"2010","unstructured":"Siatecka M, Sahr KE, Andersen SG, Mezei M, Bieker JJ, Peters LL (2010) Severe anemia in the Nan mutant mouse caused by sequence-selective disruption of erythroid Kruppel-like factor. Proc Natl Acad Sci USA 107:15151\u201315156","journal-title":"Proc Natl Acad Sci USA"},{"key":"618_CR34","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1146\/annurev.biophys.29.1.183","volume":"29","author":"SA Wolfe","year":"2000","unstructured":"Wolfe SA, Nekludova L, Pabo CO (2000) DNA recognition by Cys2His2 zinc finger proteins. Annu Rev Biophys Biomol Struct 29:183\u2013212","journal-title":"Annu Rev Biophys Biomol Struct"},{"key":"618_CR35","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1080\/07391102.1988.10506483","volume":"6","author":"R Lavery","year":"1988","unstructured":"Lavery R, Sklenar H (1988) The definition of generalized helicoidal parameters and of axis curvature for irregular nucleic acids. J Biomol Struct Dyn 6:63\u201391","journal-title":"J Biomol Struct Dyn"},{"key":"618_CR36","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0301-4622(94)85028-3","volume":"50","author":"U Heinemann","year":"1994","unstructured":"Heinemann U, Alings C, Hahn M (1994) Crystallographic studies of DNA helix structure. Biophys Chem 50:157\u2013167","journal-title":"Biophys Chem"},{"key":"618_CR37","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/0022-2836(89)90337-9","volume":"210","author":"U Heinemann","year":"1989","unstructured":"Heinemann U, Alings C (1989) Crystallographic study of one turn of G\/C-rich B-DNA. J Mol Biol 210:369\u2013381","journal-title":"J Mol Biol"},{"key":"618_CR38","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/j.1460-2075.1991.tb07918.x","volume":"10","author":"U Heinemann","year":"1991","unstructured":"Heinemann U, Alings C (1991) The conformation of a B-DNA decamer is mainly determined by its sequence and not by crystal environment. EMBO J 10:35\u201343","journal-title":"EMBO J"},{"key":"618_CR39","doi-asserted-by":"crossref","unstructured":"Tolstorukov MY, Colasanti AV, McCandlish DM, Olson WK, Zhurkin VB (2007) A novel roll-and-slide mechanism of DNA folding in chromatin: implications for nucleosome positioning. J Mol Biol 371:725\u2013738","DOI":"10.1016\/j.jmb.2007.05.048"},{"key":"618_CR40","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1093\/nar\/23.10.1686","volume":"23","author":"TD Littlewood","year":"1995","unstructured":"Littlewood TD, Hancock DC, Danielian PS, Parker MG, Evan GI (1995) A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins. Nucleic Acids Res 23:1686\u20131690","journal-title":"Nucleic Acids Res"},{"key":"618_CR41","doi-asserted-by":"crossref","first-page":"20009","DOI":"10.1074\/jbc.271.33.20009","volume":"271","author":"JM Shields","year":"1996","unstructured":"Shields JM, Christy RJ, Yang VW (1996) Identification and characterization of a gene encoding a gut-enriched Kr\u00fcppel-like factor expressed during growth arrest. J Biol Chem 271:20009\u201320017","journal-title":"J Biol Chem"},{"key":"618_CR42","doi-asserted-by":"crossref","first-page":"8035","DOI":"10.1128\/MCB.22.22.8035-8043.2002","volume":"22","author":"E Schaller","year":"2002","unstructured":"Schaller E, Macfarlane AJ, Rupec RA, Gordon S, McKnight AJ, Pfeffer K (2002) Inactivation of the F4\/80 glycoprotein in the mouse germ line. Mol Cell Biol 22:8035\u20138043","journal-title":"Mol Cell Biol"},{"key":"618_CR43","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1093\/nar\/28.5.1106","volume":"28","author":"DE Geiman","year":"2000","unstructured":"Geiman DE, Ton-That H, Johnson JM, Yang VW (2000) Transactivation and growth suppression by the gut-enriched Kr\u00fcppel-like factor (Kr\u00fcppel-like factor 4) are dependent on acidic amino acid residues and protein\u2013protein interaction. Nucleic Acids Res 28:1106\u20131113","journal-title":"Nucleic Acids Res"},{"key":"618_CR44","doi-asserted-by":"crossref","first-page":"2969","DOI":"10.1002\/stem.231","volume":"27","author":"Z Wei","year":"2009","unstructured":"Wei Z, Yang Y, Zhang P, Andrianakos R, Hasegawa K, Lyu J, Chen X, Bai G, Liu C, Pera M, Lu W (2009) Klf4 interacts directly with Oct4 and Sox2 to promote reprogramming. Stem Cells 27:2969\u20132978","journal-title":"Stem Cells"},{"key":"618_CR45","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1182\/blood-2002-04-1199","volume":"100","author":"JW Vardiman","year":"2002","unstructured":"Vardiman JW, Harris NL, Brunning RD (2002) The World Health Organization (WHO) classification of the myeloid neoplasms. Blood 100:2292\u20132302","journal-title":"Blood"}],"container-title":["Cellular and Molecular Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-010-0618-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00018-010-0618-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-010-0618-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T02:15:57Z","timestamp":1685931357000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00018-010-0618-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,3]]},"references-count":45,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["618"],"URL":"https:\/\/doi.org\/10.1007\/s00018-010-0618-x","relation":{},"ISSN":["1420-682X","1420-9071"],"issn-type":[{"value":"1420-682X","type":"print"},{"value":"1420-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,3]]}}}