{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T14:32:16Z","timestamp":1791815536802,"version":"4.3.4"},"reference-count":92,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2013,11,14]],"date-time":"2013-11-14T00:00:00Z","timestamp":1384387200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell. Mol. Life Sci."],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1007\/s00018-013-1508-9","type":"journal-article","created":{"date-parts":[[2013,11,13]],"date-time":"2013-11-13T11:24:46Z","timestamp":1384341886000},"page":"1469-1476","source":"Crossref","is-referenced-by-count":25,"title":["The role of the insulin-like growth factor (IGF) axis in osteogenic and odontogenic differentiation"],"prefix":"10.1007","volume":"71","author":[{"given":"H.","family":"Al-Kharobi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"El-Gendy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. A.","family":"Devine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Beattie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,11,14]]},"reference":[{"issue":"1","key":"1508_CR1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00592-010-0227-z","volume":"48","author":"M Annunziata","year":"2011","unstructured":"Annunziata M, Granata R, Ghigo E (2011) The IGF system. Acta Diabetol 48(1):1\u20139","journal-title":"Acta Diabetol"},{"issue":"1","key":"1508_CR2","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1006\/excr.1998.4113","volume":"242","author":"K Reiss","year":"1998","unstructured":"Reiss K et al (1998) Molecular markers of IGF-I-mediated mitogenesis. Exp Cell Res 242(1):361\u2013372","journal-title":"Exp Cell Res"},{"issue":"4","key":"1508_CR3","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.cytogfr.2006.02.002","volume":"17","author":"R Kooijman","year":"2006","unstructured":"Kooijman R (2006) Regulation of apoptosis by insulin-like growth factor (IGF)-I. Cytokine Growth Factor Rev 17(4):305\u2013323","journal-title":"Cytokine Growth Factor Rev"},{"issue":"2\u20134","key":"1508_CR4","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0955-2235(95)00015-1","volume":"6","author":"JI Jones","year":"1995","unstructured":"Jones JI, Doerr ME, Clemmons DR (1995) Cell migration: interactions among integrins, IGFs and IGFBPs. Prog Growth Factor Res 6(2\u20134):319\u2013327","journal-title":"Prog Growth Factor Res"},{"issue":"2","key":"1508_CR5","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/jcp.10207","volume":"194","author":"L Mauro","year":"2003","unstructured":"Mauro L et al (2003) Role of the IGF-I receptor in the regulation of cell\u2013cell adhesion: implications in cancer development and progression. J Cell Physiol 194(2):108\u2013116","journal-title":"J Cell Physiol"},{"issue":"3","key":"1508_CR6","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1136\/mp.54.3.133","volume":"54","author":"B Valentinis","year":"2001","unstructured":"Valentinis B, Baserga R (2001) IGF-I receptor signalling in transformation and differentiation. Mol Pathol 54(3):133\u2013137","journal-title":"Mol Pathol"},{"issue":"3\u20134","key":"1508_CR7","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.cytogfr.2007.04.001","volume":"18","author":"D Chesik","year":"2007","unstructured":"Chesik D, De Keyser J, Wilczak N (2007) Insulin-like growth factor binding protein-2 as a regulator of IGF actions in CNS: implications in multiple sclerosis. Cytokine Growth Factor Rev 18(3\u20134):267\u2013278","journal-title":"Cytokine Growth Factor Rev"},{"issue":"3","key":"1508_CR8","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.ygcen.2010.04.009","volume":"167","author":"C Duan","year":"2010","unstructured":"Duan C, Ren H, Gao S (2010) Insulin-like growth factors (IGFs), IGF receptors, and IGF-binding proteins: roles in skeletal muscle growth and differentiation. Gen Comp Endocrinol 167(3):344\u2013351","journal-title":"Gen Comp Endocrinol"},{"issue":"2","key":"1508_CR9","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1002\/jcp.20587","volume":"207","author":"JD Lochrie","year":"2006","unstructured":"Lochrie JD et al (2006) Insulin-like growth factor binding protein (IGFBP)-5 is upregulated during both differentiation and apoptosis in primary cultures of mouse mammary epithelial cells. J Cell Physiol 207(2):471\u2013479","journal-title":"J Cell Physiol"},{"issue":"2","key":"1508_CR10","doi-asserted-by":"crossref","first-page":"143","DOI":"10.2174\/1874467211205020143","volume":"5","author":"KE Govoni","year":"2012","unstructured":"Govoni KE (2012) Insulin-like growth factor-I molecular pathways in osteoblasts: potential targets for pharmacological manipulation. Curr Mol Pharmacol 5(2):143\u2013152","journal-title":"Curr Mol Pharmacol"},{"issue":"5","key":"1508_CR11","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1002\/jcp.22905","volume":"227","author":"AS Patil","year":"2012","unstructured":"Patil AS, Sable RB, Kothari RM (2012) Role of insulin-like growth factors (IGFs), their receptors and genetic regulation in the chondrogenesis and growth of the mandibular condylar cartilage. J Cell Physiol 227(5):1796\u20131804","journal-title":"J Cell Physiol"},{"issue":"2","key":"1508_CR12","doi-asserted-by":"crossref","first-page":"272","DOI":"10.7150\/ijbs.2929","volume":"8","author":"G Chen","year":"2012","unstructured":"Chen G, Deng C, Li YP (2012) TGF-beta and BMP signalling in osteoblast differentiation and bone formation. Int J Biol Sci 8(2):272\u2013288","journal-title":"Int J Biol Sci"},{"issue":"11","key":"1508_CR13","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1002\/bies.201200061","volume":"34","author":"S Marcellini","year":"2012","unstructured":"Marcellini S, Henriquez JP, Bertin A (2012) Control of osteogenesis by the canonical Wnt and BMP pathways in vivo: cooperation and antagonism between the canonical Wnt and BMP pathways as cells differentiate from osteochondroprogenitors to osteoblasts and osteocytes. BioEssays 34(11):953\u2013962","journal-title":"BioEssays"},{"key":"1508_CR14","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1146\/annurev.ph.47.030185.002303","volume":"47","author":"ER Froesch","year":"1985","unstructured":"Froesch ER et al (1985) Actions of insulin-like growth factors. Annu Rev Physiol 47:443\u2013467","journal-title":"Annu Rev Physiol"},{"issue":"4592","key":"1508_CR15","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1126\/science.6338593","volume":"220","author":"GS Tannenbaum","year":"1983","unstructured":"Tannenbaum GS, Guyda HJ, Posner BI (1983) Insulin-like growth factors: a role in growth hormone negative feedback and body weight regulation via brain. Science 220(4592):77\u201379","journal-title":"Science"},{"key":"1508_CR16","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/978-1-4615-2988-0_7","volume":"343","author":"JS Sussenbach","year":"1993","unstructured":"Sussenbach JS et al (1993) Transcriptional and post-transcriptional regulation of the human IGF-II gene expression. Adv Exp Med Biol 343:63\u201371","journal-title":"Adv Exp Med Biol"},{"key":"1508_CR17","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/0470869976.ch10","volume":"262","author":"P Meyts De","year":"2004","unstructured":"De Meyts P et al (2004) Structural biology of insulin and IGF-1 receptors. Novartis Found Symp 262:160\u2013171 (discussion 171\u20136, 265\u20138)","journal-title":"Novartis Found Symp"},{"issue":"6137","key":"1508_CR18","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/329301a0","volume":"329","author":"DO Morgan","year":"1987","unstructured":"Morgan DO et al (1987) Insulin-like growth factor II receptor as a multifunctional binding protein. Nature 329(6137):301\u2013307","journal-title":"Nature"},{"issue":"6422","key":"1508_CR19","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/362747a0","volume":"362","author":"S Rainier","year":"1993","unstructured":"Rainier S et al (1993) Relaxation of imprinted genes in human cancer. Nature 362(6422):747\u2013749","journal-title":"Nature"},{"issue":"2","key":"1508_CR20","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1006\/bbrc.1993.2542","volume":"197","author":"Y Xu","year":"1993","unstructured":"Xu Y et al (1993) Functional polymorphism in the parental imprinting of the human IGF2R gene. Biochem Biophys Res Commun 197(2):747\u2013754","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"1508_CR21","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1530\/JME-11-0022","volume":"47","author":"K Siddle","year":"2011","unstructured":"Siddle K (2011) Signalling by insulin and IGF receptors: supporting acts and new players. J Mol Endocrinol 47(1):R1\u2013R10","journal-title":"J Mol Endocrinol"},{"issue":"5","key":"1508_CR22","doi-asserted-by":"crossref","first-page":"3090","DOI":"10.1016\/S0021-9258(17)43264-9","volume":"259","author":"KT Yu","year":"1984","unstructured":"Yu KT, Czech MP (1984) The type I insulin-like growth factor receptor mediates the rapid effects of multiplication-stimulating activity on membrane transport systems in rat soleus muscle. J Biol Chem 259(5):3090\u20133095","journal-title":"J Biol Chem"},{"issue":"1\u20132","key":"1508_CR23","first-page":"221","volume":"307","author":"J Beattie","year":"2008","unstructured":"Beattie J et al (2008) Molecular interactions in the insulin-like growth factor (IGF) axis: a surface plasmon resonance (SPR) based biosensor study. Mol Cell Biochem 307(1\u20132):221\u2013236","journal-title":"Mol Cell Biochem"},{"issue":"4\u20135","key":"1508_CR24","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.cytogfr.2005.04.004","volume":"16","author":"A Denley","year":"2005","unstructured":"Denley A et al (2005) Molecular interactions of the IGF system. Cytokine Growth Factor Rev 16(4\u20135):421\u2013439","journal-title":"Cytokine Growth Factor Rev"},{"issue":"6","key":"1508_CR25","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1210\/edrv.22.6.0449","volume":"22","author":"DR Clemmons","year":"2001","unstructured":"Clemmons DR (2001) Use of mutagenesis to probe IGF-binding protein structure\/function relationships. Endocr Rev 22(6):800\u2013817","journal-title":"Endocr Rev"},{"issue":"24","key":"1508_CR26","doi-asserted-by":"crossref","first-page":"21285","DOI":"10.1074\/jbc.M112082200","volume":"277","author":"M Zhang","year":"2002","unstructured":"Zhang M et al (2002) Targeted expression of a protease-resistant IGFBP-4 mutant in smooth muscle of transgenic mice results in IGFBP-4 stabilization and smooth muscle hypotrophy. J Biol Chem 277(24):21285\u201321290","journal-title":"J Biol Chem"},{"issue":"5","key":"1508_CR27","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1210\/endo-127-5-2270","volume":"127","author":"PJ Fielder","year":"1990","unstructured":"Fielder PJ et al (1990) Characterization of insulin-like growth factor binding proteins (IGFBPs) during gestation in mice: effects of hypophysectomy and an IGFBP-specific serum protease activity. Endocrinology 127(5):2270\u20132280","journal-title":"Endocrinology"},{"issue":"30","key":"1508_CR28","doi-asserted-by":"crossref","first-page":"22305","DOI":"10.1016\/S0021-9258(18)41529-3","volume":"268","author":"PL James","year":"1993","unstructured":"James PL et al (1993) A highly conserved insulin-like growth factor-binding protein (IGFBP-5) is expressed during myoblast differentiation. J Biol Chem 268(30):22305\u201322312","journal-title":"J Biol Chem"},{"issue":"Pt 7","key":"1508_CR29","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1242\/jcs.092882","volume":"125","author":"A Sureshbabu","year":"2012","unstructured":"Sureshbabu A et al (2012) IGFBP5 induces cell adhesion, increases cell survival and inhibits cell migration in MCF-7 human breast cancer cells. J Cell Sci 125(Pt 7):1693\u20131705","journal-title":"J Cell Sci"},{"issue":"1","key":"1508_CR30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20060086","volume":"395","author":"J Beattie","year":"2006","unstructured":"Beattie J et al (2006) Insulin-like growth factor-binding protein-5 (IGFBP-5): a critical member of the IGF axis. Biochem J 395(1):1\u201319","journal-title":"Biochem J"},{"issue":"1","key":"1508_CR31","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1530\/acta.0.1070016","volume":"107","author":"H Stracke","year":"1984","unstructured":"Stracke H et al (1984) Effect of growth hormone on osteoblasts and demonstration of somatomedin-C\/IGF I in bone organ culture. Acta Endocrinol (Copenh) 107(1):16\u201324","journal-title":"Acta Endocrinol (Copenh)"},{"issue":"4","key":"1508_CR32","first-page":"160","volume":"1","author":"BA Scheven","year":"1991","unstructured":"Scheven BA et al (1991) Effects of recombinant human insulin-like growth factor I and II (IGF-I\/-II) and growth hormone (GH) on the growth of normal adult human osteoblast-like cells and human osteogenic sarcoma cells. Growth Regul 1(4):160\u2013167","journal-title":"Growth Regul"},{"issue":"3","key":"1508_CR33","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1046\/j.1365-2362.1998.00265.x","volume":"28","author":"BL Langdahl","year":"1998","unstructured":"Langdahl BL et al (1998) The effects of IGF-I and IGF-II on proliferation and differentiation of human osteoblasts and interactions with growth hormone. Eur J Clin Invest 28(3):176\u2013183","journal-title":"Eur J Clin Invest"},{"issue":"2","key":"1508_CR34","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1210\/endo-127-2-807","volume":"127","author":"M Ernst","year":"1990","unstructured":"Ernst M, Rodan GA (1990) Increased activity of insulin-like growth factor (IGF) in osteoblastic cells in the presence of growth hormone (GH): positive correlation with the presence of the GH-induced IGF-binding protein BP-3. Endocrinology 127(2):807\u2013814","journal-title":"Endocrinology"},{"issue":"2","key":"1508_CR35","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/jbmr.5650050206","volume":"5","author":"GL Wong","year":"1990","unstructured":"Wong GL et al (1990) IGF-I production by mouse osteoblasts. J Bone Miner Res 5(2):133\u2013140","journal-title":"J Bone Miner Res"},{"issue":"1","key":"1508_CR36","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/0006-291X(91)91410-E","volume":"179","author":"C Schmid","year":"1991","unstructured":"Schmid C et al (1991) Intact but not truncated insulin-like growth factor binding protein-3 (IGFBP-3) blocks IGF I-induced stimulation of osteoblasts: control of IGF signalling to bone cells by IGFBP-3-specific proteolysis? Biochem Biophys Res Commun 179(1):579\u2013585","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"1508_CR37","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1677\/joe.0.1250271","volume":"125","author":"MC Slootweg","year":"1990","unstructured":"Slootweg MC et al (1990) The presence of classical insulin-like growth factor (IGF) type-I and -II receptors on mouse osteoblasts: autocrine\/paracrine growth effect of IGFs? J Endocrinol 125(2):271\u2013277","journal-title":"J Endocrinol"},{"issue":"1","key":"1508_CR38","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1080\/09513590400020831","volume":"20","author":"S Mochizuki","year":"2005","unstructured":"Mochizuki S et al (2005) Effects of estriol on proliferative activity and expression of insulin-like growth factor-I (IGF-I) and IGF-I receptor mRNA in cultured human osteoblast-like osteosarcoma cells. Gynecol Endocrinol 20(1):6\u201312","journal-title":"Gynecol Endocrinol"},{"issue":"1","key":"1508_CR39","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.bbamcr.2005.11.001","volume":"1763","author":"LC Yeh","year":"2006","unstructured":"Yeh LC, Lee JC (2006) Co-transfection with the osteogenic protein (OP)-1 gene and the insulin-like growth factor (IGF)-I gene enhanced osteoblastic cell differentiation. Biochim Biophys Acta 1763(1):57\u201363","journal-title":"Biochim Biophys Acta"},{"issue":"10","key":"1508_CR40","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1210\/mend.15.10.0704","volume":"15","author":"AM Delany","year":"2001","unstructured":"Delany AM, Durant D, Canalis E (2001) Glucocorticoid suppression of IGF I transcription in osteoblasts. Mol Endocrinol 15(10):1781\u20131789","journal-title":"Mol Endocrinol"},{"issue":"21","key":"1508_CR41","doi-asserted-by":"crossref","first-page":"19149","DOI":"10.1074\/jbc.M110.197905","volume":"286","author":"S Yang","year":"2011","unstructured":"Yang S et al (2011) Foxo1 mediates insulin-like growth factor 1 (IGF1)\/insulin regulation of osteocalcin expression by antagonizing Runx2 in osteoblasts. J Biol Chem 286(21):19149\u201319158","journal-title":"J Biol Chem"},{"issue":"5","key":"1508_CR42","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.bone.2008.07.241","volume":"43","author":"M Nakasaki","year":"2008","unstructured":"Nakasaki M et al (2008) IGF-I secreted by osteoblasts acts as a potent chemotactic factor for osteoblasts. Bone 43(5):869\u2013879","journal-title":"Bone"},{"issue":"2","key":"1508_CR43","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s00441-008-0690-9","volume":"334","author":"N Hatakeyama","year":"2008","unstructured":"Hatakeyama N et al (2008) IGF-I regulates tight-junction protein claudin-1 during differentiation of osteoblast-like MC3T3-E1 cells via a MAP-kinase pathway. Cell Tissue Res 334(2):243\u2013254","journal-title":"Cell Tissue Res"},{"issue":"5","key":"1508_CR44","doi-asserted-by":"crossref","first-page":"318","DOI":"10.3109\/08977191003766874","volume":"28","author":"LC Yeh","year":"2010","unstructured":"Yeh LC et al (2010) Protein kinase D mediates the synergistic effects of BMP-7 and IGF-I on osteoblastic cell differentiation. Growth Factors 28(5):318\u2013328","journal-title":"Growth Factors"},{"issue":"46","key":"1508_CR45","doi-asserted-by":"crossref","first-page":"44005","DOI":"10.1074\/jbc.M208265200","volume":"277","author":"M Zhang","year":"2002","unstructured":"Zhang M et al (2002) Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signalling in bone matrix mineralization. J Biol Chem 277(46):44005\u201344012","journal-title":"J Biol Chem"},{"issue":"3","key":"1508_CR46","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1210\/me.2009-0357","volume":"24","author":"Y Gan","year":"2010","unstructured":"Gan Y et al (2010) Deletion of IGF-I receptor (IGF-IR) in primary osteoblasts reduces GH-induced STAT5 signalling. Mol Endocrinol 24(3):644\u2013656","journal-title":"Mol Endocrinol"},{"issue":"2","key":"1508_CR47","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/jcb.240590213","volume":"59","author":"DA Martinez","year":"1995","unstructured":"Martinez DA et al (1995) Identification of functional insulin-like growth factor-II\/mannose-6-phosphate receptors in isolated bone cells. J Cell Biochem 59(2):246\u2013257","journal-title":"J Cell Biochem"},{"issue":"3","key":"1508_CR48","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1530\/eje.0.1310293","volume":"131","author":"SH Scharla","year":"1994","unstructured":"Scharla SH et al (1994) Effect of tumor necrosis factor-alpha on the expression of insulin-like growth factor I and insulin-like growth factor binding protein 4 in mouse osteoblasts. Eur J Endocrinol 131(3):293\u2013301","journal-title":"Eur J Endocrinol"},{"issue":"6","key":"1508_CR49","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1210\/endo.135.6.7527330","volume":"135","author":"C Lalou","year":"1994","unstructured":"Lalou C et al (1994) Interactions between insulin-like growth factor-I (IGF-I) and the system of plasminogen activators and their inhibitors in the control of IGF-binding protein-3 production and proteolysis in human osteosarcoma cells. Endocrinology 135(6):2318\u20132326","journal-title":"Endocrinology"},{"issue":"31","key":"1508_CR50","doi-asserted-by":"crossref","first-page":"22467","DOI":"10.1016\/S0021-9258(18)41695-X","volume":"267","author":"DL Andress","year":"1992","unstructured":"Andress DL, Birnbaum RS (1992) Human osteoblast-derived insulin-like growth factor (IGF) binding protein-5 stimulates osteoblast mitogenesis and potentiates IGF action. J Biol Chem 267(31):22467\u201322472","journal-title":"J Biol Chem"},{"issue":"2\u20134","key":"1508_CR51","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0955-2235(95)00008-9","volume":"6","author":"DL Andress","year":"1995","unstructured":"Andress DL (1995) Comparison studies of IGFBP-5 binding to osteoblasts and osteoblast-derived extracellular matrix. Prog Growth Factor Res 6(2\u20134):337\u2013344","journal-title":"Prog Growth Factor Res"},{"issue":"2\u20134","key":"1508_CR52","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0955-2235(95)00037-2","volume":"6","author":"C Schmid","year":"1995","unstructured":"Schmid C et al (1995) Expression, effects, and fate of IGFBP-5 are different in normal and malignant osteoblastic cells. Prog Growth Factor Res 6(2\u20134):167\u2013173","journal-title":"Prog Growth Factor Res"},{"issue":"47","key":"1508_CR53","doi-asserted-by":"crossref","first-page":"28289","DOI":"10.1074\/jbc.270.47.28289","volume":"270","author":"DL Andress","year":"1995","unstructured":"Andress DL (1995) Heparin modulates the binding of insulin-like growth factor (IGF) binding protein-5 to a membrane protein in osteoblastic cells. J Biol Chem 270(47):28289\u201328296","journal-title":"J Biol Chem"},{"issue":"Suppl 5","key":"1508_CR54","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1159\/000191328","volume":"48","author":"K Chihara","year":"1997","unstructured":"Chihara K, Sugimoto T (1997) The action of GH\/IGF-I\/IGFBP in osteoblasts and osteoclasts. Horm Res 48(Suppl 5):45\u201349","journal-title":"Horm Res"},{"issue":"2","key":"1508_CR55","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1677\/joe.0.1670305","volume":"167","author":"M Nasu","year":"2000","unstructured":"Nasu M et al (2000) Estrogen modulates osteoblast proliferation and function regulated by parathyroid hormone in osteoblastic SaOS-2 cells: role of insulin-like growth factor (IGF)-I and IGF-binding protein-5. J Endocrinol 167(2):305\u2013313","journal-title":"J Endocrinol"},{"issue":"2","key":"1508_CR56","doi-asserted-by":"crossref","first-page":"E283","DOI":"10.1152\/ajpendo.2001.281.2.E283","volume":"281","author":"DL Andress","year":"2001","unstructured":"Andress DL (2001) IGF-binding protein-5 stimulates osteoblast activity and bone accretion in ovariectomized mice. Am J Physiol Endocrinol Metab 281(2):E283\u2013E288","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"8","key":"1508_CR57","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1359\/JBMR.050311","volume":"20","author":"YG Amaar","year":"2005","unstructured":"Amaar YG, Baylink DJ, Mohan S (2005) Ras-association domain family 1 protein, RASSF1C, is an IGFBP-5 binding partner and a potential regulator of osteoblast cell proliferation. J Bone Miner Res 20(8):1430\u20131439","journal-title":"J Bone Miner Res"},{"issue":"4","key":"1508_CR58","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/biof.5520290403","volume":"29","author":"SK Kim","year":"2007","unstructured":"Kim SK, Kwon JY, Nam TJ (2007) Involvement of ligand occupancy in insulin-like growth factor-I (IGF-I) induced cell growth in osteoblast like MC3T3-E1 cells. BioFactors 29(4):187\u2013202","journal-title":"BioFactors"},{"issue":"8","key":"1508_CR59","doi-asserted-by":"crossref","first-page":"3527","DOI":"10.1210\/endo.136.8.7543045","volume":"136","author":"KM Thrailkill","year":"1995","unstructured":"Thrailkill KM et al (1995) Characterization of insulin-like growth factor-binding protein 5-degrading proteases produced throughout murine osteoblast differentiation. Endocrinology 136(8):3527\u20133533","journal-title":"Endocrinology"},{"issue":"6","key":"1508_CR60","first-page":"1752","volume":"79","author":"SK Durham","year":"1994","unstructured":"Durham SK, Riggs BL, Conover CA (1994) The insulin-like growth factor-binding protein-4 (IGFBP-4)-IGFBP-4 protease system in normal human osteoblast-like cells: regulation by transforming growth factor-beta. J Clin Endocrinol Metab 79(6):1752\u20131758","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"1508_CR61","first-page":"104","volume":"80","author":"SK Durham","year":"1995","unstructured":"Durham SK et al (1995) Regulation of insulin-like growth factor (IGF)-binding protein-4 availability in normal human osteoblast-like cells: role of endogenous IGFs. J Clin Endocrinol Metab 80(1):104\u2013110","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"1508_CR62","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.bbrc.2004.10.092","volume":"325","author":"RC Bunn","year":"2004","unstructured":"Bunn RC et al (2004) IGFBP-4 degradation by pregnancy-associated plasma protein-A in MC3T3 osteoblasts. Biochem Biophys Res Commun 325(3):698\u2013706","journal-title":"Biochem Biophys Res Commun"},{"issue":"12","key":"1508_CR63","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1359\/jbmr.1999.14.12.2079","volume":"14","author":"X Qin","year":"1999","unstructured":"Qin X et al (1999) Studies on the role of human insulin-like growth factor-II (IGF-II)-dependent IGF binding protein (hIGFBP)-4 protease in human osteoblasts using protease-resistant IGFBP-4 analogs. J Bone Miner Res 14(12):2079\u20132088","journal-title":"J Bone Miner Res"},{"issue":"5","key":"1508_CR64","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1359\/jbmr.2003.18.5.836","volume":"18","author":"M Zhang","year":"2003","unstructured":"Zhang M et al (2003) Paracrine overexpression of IGFBP-4 in osteoblasts of transgenic mice decreases bone turnover and causes global growth retardation. J Bone Miner Res 18(5):836\u2013843","journal-title":"J Bone Miner Res"},{"issue":"5","key":"1508_CR65","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1002\/jcb.21761","volume":"104","author":"C Strohbach","year":"2008","unstructured":"Strohbach C et al (2008) Potential involvement of the interaction between insulin-like growth factor binding protein (IGFBP)-6 and LIM mineralization protein (LMP)-1 in regulating osteoblast differentiation. J Cell Biochem 104(5):1890\u20131905","journal-title":"J Cell Biochem"},{"issue":"2","key":"1508_CR66","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.bbagrm.2008.08.013","volume":"1789","author":"LA Perez-Casellas","year":"2009","unstructured":"Perez-Casellas LA et al (2009) Nuclear factor I transcription factors regulate IGF binding protein 5 gene transcription in human osteoblasts. Biochim Biophys Acta 1789(2):78\u201387","journal-title":"Biochim Biophys Acta"},{"issue":"2 Pt 1","key":"1508_CR67","first-page":"E226","volume":"267","author":"C Schmid","year":"1994","unstructured":"Schmid C et al (1994) Growth hormone and parathyroid hormone stimulate IGFBP-3 in rat osteoblasts. Am J Physiol 267(2 Pt 1):E226\u2013E233","journal-title":"Am J Physiol"},{"issue":"1","key":"1508_CR68","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0014-5793(96)00777-6","volume":"392","author":"C Schmid","year":"1996","unstructured":"Schmid C et al (1996) 1 alpha, 25-dihydroxyvitamin D3 increases IGF binding protein-5 expression in cultured osteoblasts. FEBS Lett 392(1):21\u201324","journal-title":"FEBS Lett"},{"issue":"5","key":"1508_CR69","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1530\/acta.0.1260467","volume":"126","author":"C Schmid","year":"1992","unstructured":"Schmid C et al (1992) Triiodothyronine (T3) stimulates insulin-like growth factor (IGF)-1 and IGF binding protein (IGFBP)-2 production by rat osteoblasts in vitro. Acta Endocrinol (Copenh) 126(5):467\u2013473","journal-title":"Acta Endocrinol (Copenh)"},{"issue":"2","key":"1508_CR70","first-page":"103","volume":"55","author":"C Lalou","year":"1994","unstructured":"Lalou C et al (1994) Interactions of insulin-like growth factors (IGF) and their binding proteins with the plasminogen\/plasmin activator system in cultured osteoblasts. Ann Endocrinol (Paris) 55(2):103\u2013107","journal-title":"Ann Endocrinol (Paris)"},{"issue":"2","key":"1508_CR71","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/jbmr.5650100208","volume":"10","author":"MM Hurley","year":"1995","unstructured":"Hurley MM, Abreu C, Hakeda Y (1995) Basic fibroblast growth factor regulates IGF-I binding proteins in the clonal osteoblastic cell line MC3T3-E1. J Bone Miner Res 10(2):222\u2013230","journal-title":"J Bone Miner Res"},{"issue":"3","key":"1508_CR72","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/8756-3282(95)00223-Z","volume":"17","author":"KM Thrailkill","year":"1995","unstructured":"Thrailkill KM et al (1995) Differentiation of MC3T3-E1 osteoblasts is associated with temporal changes in the expression of IGF-I and IGFBPs. Bone 17(3):307\u2013313","journal-title":"Bone"},{"issue":"2","key":"1508_CR73","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1677\/joe.0.1440251","volume":"144","author":"RS Birnbaum","year":"1995","unstructured":"Birnbaum RS, Bowsher RR, Wiren KM (1995) Changes in IGF-I and -II expression and secretion during the proliferation and differentiation of normal rat osteoblasts. J Endocrinol 144(2):251\u2013259","journal-title":"J Endocrinol"},{"issue":"4","key":"1508_CR74","doi-asserted-by":"crossref","first-page":"E648","DOI":"10.1152\/ajpendo.00049.2003","volume":"286","author":"C Palermo","year":"2004","unstructured":"Palermo C et al (2004) Potentiating role of IGFBP-2 on IGF-II-stimulated alkaline phosphatase activity in differentiating osteoblasts. Am J Physiol Endocrinol Metab 286(4):E648\u2013E657","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"1","key":"1508_CR75","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1006\/bbrc.1995.1962","volume":"212","author":"C Schmid","year":"1995","unstructured":"Schmid C et al (1995) Effects of insulin-like growth factor (IGF) binding proteins (BPs)-3 and -6 on DNA synthesis of rat osteoblasts: further evidence for a role of auto-\/paracrine IGF I but not IGF II in stimulating osteoblast growth. Biochem Biophys Res Commun 212(1):242\u2013248","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"1508_CR76","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/8756-3282(94)00040-9","volume":"16","author":"J Middleton","year":"1995","unstructured":"Middleton J et al (1995) Osteoblasts and osteoclasts in adult human osteophyte tissue express the mRNAs for insulin-like growth factors I and II and the type 1 IGF receptor. Bone 16(3):287\u2013293","journal-title":"Bone"},{"issue":"6","key":"1508_CR77","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/S1096-6374(03)00092-3","volume":"13","author":"CA Conover","year":"2003","unstructured":"Conover CA, Khosla S (2003) Role of extracellular matrix in insulin-like growth factor (IGF) binding protein-2 regulation of IGF-II action in normal human osteoblasts. Growth Horm IGF Res 13(6):328\u2013335","journal-title":"Growth Horm IGF Res"},{"issue":"4","key":"1508_CR78","doi-asserted-by":"crossref","first-page":"461","DOI":"10.2478\/s11658-006-0038-y","volume":"11","author":"BM Abdallah","year":"2006","unstructured":"Abdallah BM (2006) Osteoblast differentiation of NIH3T3 fibroblasts is associated with changes in the IGF-I\/IGFBP expression pattern. Cell Mol Biol Lett 11(4):461\u2013474","journal-title":"Cell Mol Biol Lett"},{"issue":"3","key":"1508_CR79","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0003-9969(92)90093-N","volume":"37","author":"M Nakashima","year":"1992","unstructured":"Nakashima M (1992) The effects of growth factors on DNA synthesis, proteoglycan synthesis and alkaline phosphatase activity in bovine dental pulp cells. Arch Oral Biol 37(3):231\u2013236","journal-title":"Arch Oral Biol"},{"issue":"4","key":"1508_CR80","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1046\/j.1365-2591.1998.00161.x","volume":"31","author":"IA Denholm","year":"1998","unstructured":"Denholm IA, Moule AJ, Bartold PM (1998) The behaviour and proliferation of human dental pulp cell strains in vitro, and their response to the application of platelet-derived growth factor-BB and insulin-like growth factor-1. Int Endod J 31(4):251\u2013258","journal-title":"Int Endod J"},{"issue":"1\u20132","key":"1508_CR81","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3109\/08977199609034563","volume":"13","author":"BK Joseph","year":"1996","unstructured":"Joseph BK et al (1996) In situ hybridization evidence for a paracrine\/autocrine role for insulin-like growth factor-I in tooth development. Growth Factors 13(1\u20132):11\u201317","journal-title":"Growth Factors"},{"issue":"9","key":"1508_CR82","doi-asserted-by":"crossref","first-page":"3855","DOI":"10.1210\/endo.139.9.6211","volume":"139","author":"H Li","year":"1998","unstructured":"Li H et al (1998) Growth hormone and insulin-like growth factor I induce bone morphogenetic proteins 2 and 4: a mediator role in bone and tooth formation? Endocrinology 139(9):3855\u20133862","journal-title":"Endocrinology"},{"issue":"4","key":"1508_CR83","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0003-9969(99)00007-2","volume":"44","author":"T Onishi","year":"1999","unstructured":"Onishi T et al (1999) Stimulation of proliferation and differentiation of dog dental pulp cells in serum-free culture medium by insulin-like growth factor. Arch Oral Biol 44(4):361\u2013371","journal-title":"Arch Oral Biol"},{"issue":"6","key":"1508_CR84","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/S8756-3282(01)00612-3","volume":"29","author":"S Shi","year":"2001","unstructured":"Shi S, Robey PG, Gronthos S (2001) Comparison of human dental pulp and bone marrow stromal stem cells by cDNA microarray analysis. Bone 29(6):532\u2013539","journal-title":"Bone"},{"issue":"11","key":"1508_CR85","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1097\/01.DON.0000134203.65706.8F","volume":"30","author":"J Caviedes-Bucheli","year":"2004","unstructured":"Caviedes-Bucheli J et al (2004) Expression of insulin-like growth factor-1 receptor in human pulp tissue. J Endod 30(11):767\u2013769","journal-title":"J Endod"},{"issue":"1","key":"1508_CR86","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1159\/000078747","volume":"62","author":"KM Reichenmiller","year":"2004","unstructured":"Reichenmiller KM et al (2004) IGFs, IGFBPs, IGF-binding sites and biochemical markers of bone metabolism during differentiation in human pulp fibroblasts. Horm Res 62(1):33\u201339","journal-title":"Horm Res"},{"issue":"5","key":"1508_CR87","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.archoralbio.2005.10.005","volume":"51","author":"W Gotz","year":"2006","unstructured":"Gotz W et al (2006) Immunohistochemical localization of components of the insulin-like growth factor system in human permanent teeth. Arch Oral Biol 51(5):387\u2013395","journal-title":"Arch Oral Biol"},{"issue":"2","key":"1508_CR88","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1369\/jhc.5A6821.2005","volume":"54","author":"T Yamamoto","year":"2006","unstructured":"Yamamoto T, Oida S, Inage T (2006) Gene expression and localization of insulin-like growth factors and their receptors throughout amelogenesis in rat incisors. J Histochem Cytochem 54(2):243\u2013252","journal-title":"J Histochem Cytochem"},{"issue":"8","key":"1508_CR89","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1111\/j.1365-2591.2009.01568.x","volume":"42","author":"J Caviedes-Bucheli","year":"2009","unstructured":"Caviedes-Bucheli J et al (2009) Expression of insulin-like growth factor-1 and proliferating cell nuclear antigen in human pulp cells of teeth with complete and incomplete root development. Int Endod J 42(8):686\u2013693","journal-title":"Int Endod J"},{"key":"1508_CR90","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1749-6632.2011.06234.x","volume":"1237","author":"G Mori","year":"2011","unstructured":"Mori G et al (2011) Dental pulp stem cells: osteogenic differentiation and gene expression. Ann NY Acad Sci 1237:47\u201352","journal-title":"Ann NY Acad Sci"},{"issue":"2","key":"1508_CR91","first-page":"167","volume":"24","author":"G Mori","year":"2010","unstructured":"Mori G et al (2010) Osteogenic properties of human dental pulp stem cells. J Biol Regul Homeost Agents 24(2):167\u2013175","journal-title":"J Biol Regul Homeost Agents"},{"issue":"3","key":"1508_CR92","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.scr.2011.12.005","volume":"8","author":"S Wang","year":"2012","unstructured":"Wang S et al (2012) Insulin-like growth factor 1 can promote the osteogenic differentiation and osteogenesis of stem cells from apical papilla. Stem Cell Res 8(3):346\u2013356","journal-title":"Stem Cell Res"}],"container-title":["Cellular and Molecular Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-013-1508-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00018-013-1508-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-013-1508-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T05:51:44Z","timestamp":1647064304000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00018-013-1508-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,14]]},"references-count":92,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["1508"],"URL":"https:\/\/doi.org\/10.1007\/s00018-013-1508-9","relation":{},"ISSN":["1420-682X","1420-9071"],"issn-type":[{"value":"1420-682X","type":"print"},{"value":"1420-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,14]]}}}