{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T04:20:56Z","timestamp":1759033256412,"version":"3.41.0"},"reference-count":125,"publisher":"Springer Science and Business Media LLC","issue":"23","license":[{"start":{"date-parts":[[2015,6,13]],"date-time":"2015-06-13T00:00:00Z","timestamp":1434153600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell. Mol. Life Sci."],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1007\/s00018-015-1949-4","type":"journal-article","created":{"date-parts":[[2015,6,12]],"date-time":"2015-06-12T05:28:40Z","timestamp":1434086920000},"page":"4613-4632","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Polymeric alkylpyridinium salts permit intracellular delivery of human Tau in rat hippocampal neurons: requirement of Tau phosphorylation for functional deficits"],"prefix":"10.1007","volume":"72","author":[{"given":"Dave J.","family":"Koss","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianne","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Mietelska-Porowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Gasiorowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Sep\u010di\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"Turk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel","family":"Jaspars","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grazyna","family":"Niewiadomska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roderick H.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bettina","family":"Platt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gernot","family":"Riedel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,6,13]]},"reference":[{"issue":"4","key":"1949_CR1","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1242\/jcs.103.4.965","volume":"103","author":"NK Pryer","year":"1992","unstructured":"Pryer NK, Walker RA, Skeen VP, Bourns BD, Soboeiro MF, Salmon ED (1992) Brain microtubule-associated proteins modulate microtubule dynamic instability in vitro Real-time observations using video microscopy. J cell Sci 103(4):965\u2013976","journal-title":"J cell Sci"},{"issue":"11","key":"1949_CR2","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1007\/s00702-006-0488-4","volume":"113","author":"G Niewiadomska","year":"1996","unstructured":"Niewiadomska G, Baksalerska-pazera M, Lenarcik I (1996) Riedel G (2006) Compartmental protein expression of Tau, GSK-3beta and TrkA in cholinergic neurons of aged rats. J Neural Transm Vienna Austria 113(11):1733\u20131746","journal-title":"J Neural Transm Vienna Austria"},{"issue":"5","key":"1949_CR3","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1093\/brain\/123.5.857","volume":"123","author":"MG Spillantini","year":"2000","unstructured":"Spillantini MG, Goedert M (2000) Tau mutations in familial frontotemporal dementia. Brain J Neurol 123(5):857\u2013859","journal-title":"Brain J Neurol"},{"issue":"9","key":"1949_CR4","doi-asserted-by":"crossref","first-page":"6364","DOI":"10.1073\/pnas.092136199","volume":"99","author":"M Rapoport","year":"2002","unstructured":"Rapoport M, Dawson HN, Binder LI, Vitek MP, Ferreira A (2002) Tau is essential to beta -amyloid-induced neurotoxicity. Proc Natl Acad Sci USA 99(9):6364\u20136369","journal-title":"Proc Natl Acad Sci USA"},{"issue":"11","key":"1949_CR5","doi-asserted-by":"crossref","first-page":"4051","DOI":"10.1073\/pnas.85.11.4051","volume":"85","author":"M Goedert","year":"1988","unstructured":"Goedert M, Wischik CM, Crowther RA, Walker JE, Klug A (1988) Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein Tau. Proc Natl Acad Sci USA 85(11):4051\u20134055","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"1949_CR6","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1073\/pnas.88.6.2288","volume":"88","author":"RA Crowther","year":"1991","unstructured":"Crowther RA (1991) Straight and paired helical filaments in Alzheimer disease have a common structural unit. Proc Natl Acad Sci USA 88(6):2288\u20132292","journal-title":"Proc Natl Acad Sci USA"},{"issue":"9","key":"1949_CR7","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1212\/01.WNL.0000063311.58879.01","volume":"60","author":"P Giannakopoulos","year":"2003","unstructured":"Giannakopoulos P, Herrmann FR, Bussiere T, Bouras C, Kovari E, Perl DP, Morrison JH, Gold G, Hof PR (2003) Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer\u2019s disease. Neurology 60(9):1495\u20131500","journal-title":"Neurology"},{"issue":"5","key":"1949_CR8","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1001\/archneur.60.5.729","volume":"60","author":"AL Guillozet","year":"2003","unstructured":"Guillozet AL, Weintraub S, Mash DC, Mesulam MM (2003) Neurofibrillary tangles, amyloid, and memory in aging and mild cognitive impairment. Arch Neurol 60(5):729\u2013736","journal-title":"Arch Neurol"},{"issue":"3","key":"1949_CR9","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/0197-4580(95)00027-C","volume":"16","author":"M Morishima-kawashima","year":"1995","unstructured":"Morishima-kawashima M, Hasegawa M, Takio K, Suzuki M, Yoshida H, Watanabe A, Titani K, Ihara Y (1995) Hyperphosphorylation of Tau in PHF. Neurobiol Aging 16(3):365\u2013371 (discussion 371\u201380)","journal-title":"Neurobiol Aging"},{"issue":"1","key":"1949_CR10","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1460-9568.2006.05226.x","volume":"25","author":"JZ Wang","year":"2007","unstructured":"Wang JZ, Grundke-Iqbal I, Iqbal K (2007) Kinases and phosphatases and Tau sites involved in Alzheimer neurofibrillary degeneration. The European journal of neuroscience 25(1):59\u201368","journal-title":"The European journal of neuroscience"},{"issue":"1","key":"1949_CR11","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1523\/JNEUROSCI.22-01-00010.2002","volume":"22","author":"R Williamson","year":"2002","unstructured":"Williamson R, Scales T, Clark BR, Gibb G, Reynolds CH, Kellie S, Bird IN, Varndell IM, Sheppard PW, Everall I, Anderton BH (2002) Rapid tyrosine phosphorylation of neuronal proteins including Tau and focal adhesion kinase in response to amyloid-beta peptide exposure: involvement of Src family protein kinases. J Neurosci Off J Soc Neurosci 22(1):10\u201320","journal-title":"J Neurosci Off J Soc Neurosci"},{"issue":"9","key":"1949_CR12","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1523\/JNEUROSCI.4162-03.2004","volume":"24","author":"G Lee","year":"2004","unstructured":"Lee G, Thangavel R, Sharma VM, Litersky JM, Bhaskar K, Fang SM, Do LH, Andreadis A, van Hoesen G, Ksiezak-Reding H (2004) Phosphorylation of Tau by fyn: implications for Alzheimer\u2019s disease. J Neurosci Off J Soc Neurosci 24(9):2304\u20132312","journal-title":"J Neurosci Off J Soc Neurosci"},{"issue":"28","key":"1949_CR13","doi-asserted-by":"crossref","first-page":"6584","DOI":"10.1523\/JNEUROSCI.1487-05.2005","volume":"25","author":"P Derkinderen","year":"2005","unstructured":"Derkinderen P, Scales TM, Hanger DP, Leung KY, Byers HL, Ward MA, Lenz C, Price C, Bird IN, Perera T, Kellie S, Williamson R, Noble W, van Etten RA, Leroy K, Brion JP, Reynolds CH, Anderton BH (2005) Tyrosine 394 is phosphorylated in Alzheimer\u2019s paired helical filament Tau and in fetal Tau with c-Abl as the candidate tyrosine kinase. J Neurosci Off J Soc Neurosci 25(28):6584\u20136593","journal-title":"J Neurosci Off J Soc Neurosci"},{"issue":"3","key":"1949_CR14","doi-asserted-by":"crossref","first-page":"4671","DOI":"10.3390\/ijms15034671","volume":"15","author":"A Mietelska-Porowska","year":"2014","unstructured":"Mietelska-Porowska A, Wasik U, Goras M, Filipek A, Niewiadomska G (2014) Tau protein modifications and interactions: their role in function and dysfunction. Int J Mol Sci 15(3):4671\u20134713","journal-title":"Int J Mol Sci"},{"issue":"3","key":"1949_CR15","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0896-6273(03)00627-5","volume":"40","author":"JC Cruz","year":"2003","unstructured":"Cruz JC, Tseng HC, Goldman JA, Shih H, Tsai LH (2003) Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles. Neuron 40(3):471\u2013483","journal-title":"Neuron"},{"key":"1949_CR16","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1600-0404.1996.tb05866.x","volume":"165","author":"H Braak","year":"1996","unstructured":"Braak H, Braak E (1996) Evolution of the neuropathology of Alzheimer\u2019s disease. Acta Neurol Scand Suppl 165:3\u201312","journal-title":"Acta Neurol Scand Suppl"},{"issue":"6","key":"1949_CR17","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/S0197-4580(02)00228-2","volume":"24","author":"J Lauckner","year":"2003","unstructured":"Lauckner J, Frey P, Geula C (2003) Comparative distribution of Tau phosphorylated at Ser262 in pre-tangles and tangles. Neurobiol Aging 24(6):767\u2013776","journal-title":"Neurobiol Aging"},{"issue":"3","key":"1949_CR18","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1091\/mbc.10.3.727","volume":"10","author":"J Biernat","year":"1999","unstructured":"Biernat J, Mandelkow EM (1999) The development of cell processes induced by Tau protein requires phosphorylation of serine 262 and 356 in the repeat domain and is inhibited by phosphorylation in the proline-rich domains. Mol Biol Cell 10(3):727\u2013740","journal-title":"Mol Biol Cell"},{"issue":"14","key":"1949_CR19","doi-asserted-by":"crossref","first-page":"3650","DOI":"10.1523\/JNEUROSCI.0587-07.2007","volume":"27","author":"Z Berger","year":"2007","unstructured":"Berger Z, Roder H, Hanna A, Carlson A, Rangachari V, Yue M, Wszolek Z, Ashe K, Knight J, Dickson D, Andorfer C, Rosenberry TL, Lewis J, Hutton M, Janus C (2007) Accumulation of pathological Tau species and memory loss in a conditional model of tauopathy. J Neurosci Off J Soc Neurosci 27(14):3650\u20133662","journal-title":"J Neurosci Off J Soc Neurosci"},{"issue":"4","key":"1949_CR20","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1159\/000338152","volume":"11","author":"S Flunkert","year":"2013","unstructured":"Flunkert S, Hierzer M, Loffler T, Rabl R, Neddens J, Duller S, Schofield EL, Ward MA, Posch M, Jungwirth H, Windisch M, Hutter-Paier B (2013) Elevated levels of soluble total and hyperphosphorylated Tau result in early behavioral deficits and distinct changes in brain pathology in a new Tau transgenic mouse model. Neuro-degenerative diseases 11(4):194\u2013205","journal-title":"Neuro-degenerative diseases"},{"issue":"7","key":"1949_CR21","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1097\/NEN.0b013e318220a658","volume":"70","author":"LM Fox","year":"2011","unstructured":"Fox LM, William CM, Adamowicz DH, Pitstick R, Carlson GA, Spires-Jones TL, Hyman BT (2011) Soluble Tau species, not neurofibrillary aggregates, disrupt neural system integration in a Tau transgenic model. J Neuropathol Exp Neurol 70(7):588\u2013595","journal-title":"J Neuropathol Exp Neurol"},{"issue":"5733","key":"1949_CR22","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1126\/science.1113694","volume":"309","author":"K Santacruz","year":"2005","unstructured":"Santacruz K, Lewis J, Spires T, Paulson J, Kotilinek L, Ingelsson M, Guimaraes A, Deture M, Ramsden M, McGowan E, Forster C, Yue M, Orne J, Janus C, Mariash A, Kuskowski M, Hyman B, Hutton M, Ashe KH (2005) Tau suppression in a neurodegenerative mouse model improves memory function. Sci (New York, NY) 309(5733):476\u2013481","journal-title":"Sci (New York, NY)"},{"issue":"1\u20133","key":"1949_CR23","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1159\/000283479","volume":"7","author":"A Sydow","year":"2010","unstructured":"Sydow A, Mandelkow EM (2010) \u2018Prion-like\u2019 propagation of mouse and human Tau aggregates in an inducible mouse model of tauopathy. Neuro-degenerative Dis 7(1\u20133):28\u201331","journal-title":"Neuro-degenerative Dis"},{"issue":"10","key":"1949_CR24","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1523\/JNEUROSCI.5561-03.2004","volume":"24","author":"E Planel","year":"2004","unstructured":"Planel E, Miyasaka T, Launey T, Chui DH, Tanemura K, Sato S, Murayama O, Ishiguro K, Tatebayashi Y, Takashima A (2004) Alterations in glucose metabolism induce hypothermia leading to Tau hyperphosphorylation through differential inhibition of kinase and phosphatase activities: implications for Alzheimer\u2019s disease. J Neurosci Off J Soc Neurosci 24(10):2401\u20132411","journal-title":"J Neurosci Off J Soc Neurosci"},{"issue":"53","key":"1949_CR25","doi-asserted-by":"crossref","first-page":"54983","DOI":"10.1074\/jbc.C400508200","volume":"279","author":"D Zhu","year":"2004","unstructured":"Zhu D, Kosik KS, Meigs TE, Yanamadala V, Denker BM (2004) Galpha12 directly interacts with PP2A: evidence FOR Galpha12-stimulated PP2A phosphatase activity and dephosphorylation of microtubule-associated protein Tau. J Biol Chem 279(53):54983\u201354986","journal-title":"J Biol Chem"},{"issue":"6","key":"1949_CR26","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1083\/jcb.128.6.1131","volume":"128","author":"E Sontag","year":"1995","unstructured":"Sontag E, Nunbhakdi-Craig V, Bloom GS, Mumby MC (1995) A novel pool of protein phosphatase 2A is associated with microtubules and is regulated during the cell cycle. J Cell Biol 128(6):1131\u20131144","journal-title":"J Cell Biol"},{"issue":"6","key":"1949_CR27","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/S0896-6273(00)80250-0","volume":"17","author":"E Sontag","year":"1996","unstructured":"Sontag E, Nunbhakdi-Craig V, Lee G, Bloom GS, Mumby MC (1996) Regulation of the phosphorylation state and microtubule-binding activity of Tau by protein phosphatase 2A. Neuron 17(6):1201\u20131207","journal-title":"Neuron"},{"issue":"34","key":"1949_CR28","doi-asserted-by":"crossref","first-page":"21901","DOI":"10.1074\/jbc.273.34.21901","volume":"273","author":"H Liao","year":"1998","unstructured":"Liao H, Li Y, Brautigan DL, Gundersen GG (1998) Protein phosphatase 1 is targeted to microtubules by the microtubule-associated protein Tau. J Biol Chem 273(34):21901\u201321908","journal-title":"J Biol Chem"},{"issue":"2","key":"1949_CR29","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1111\/j.1471-4159.2004.02147.x","volume":"88","author":"CX Gong","year":"2004","unstructured":"Gong CX, Liu F, Wu G, Rossie S, Wegiel J, Li L, Grundke-Iqbal I, Iqbal K (2004) Dephosphorylation of microtubule-associated protein Tau by protein phosphatase 5. J Neurochem 88(2):298\u2013310","journal-title":"J Neurochem"},{"issue":"8","key":"1949_CR30","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1111\/j.1460-9568.2005.04391.x","volume":"22","author":"F Liu","year":"2005","unstructured":"Liu F, Grundke-Iqbal I, Iqbal K, Gong CX (2005) Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of Tau phosphorylation. Eur J Neurosci 22(8):1942\u20131950","journal-title":"Eur J Neurosci"},{"issue":"10","key":"1949_CR31","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1093\/jnen\/63.10.1080","volume":"63","author":"E Sontag","year":"2004","unstructured":"Sontag E, Hladik C, Montgomery L, Luangpirom A, Mudrak I, Ogris E, White CL III (2004) Downregulation of protein phosphatase 2A carboxyl methylation and methyltransferase may contribute to Alzheimer disease pathogenesis. J Neuropathol Exp Neurol 63(10):1080\u20131091","journal-title":"J Neuropathol Exp Neurol"},{"issue":"4","key":"1949_CR32","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1093\/jnen\/63.4.287","volume":"63","author":"E Sontag","year":"2004","unstructured":"Sontag E, Luangpirom A, Hladik C, Mudrak I, Ogris E, Speciale S, White CL III (2004) Altered expression levels of the protein phosphatase 2A ABalphaC enzyme are associated with Alzheimer disease pathology. J Neuropathol Exp Neurol 63(4):287\u2013301","journal-title":"J Neuropathol Exp Neurol"},{"issue":"6","key":"1949_CR33","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1016\/S0002-9440(10)62486-8","volume":"166","author":"H Tanimukai","year":"2005","unstructured":"Tanimukai H, Grundke-Iqbal I, Iqbal K (2005) Up-regulation of inhibitors of protein phosphatase-2A in Alzheimer\u2019s disease. Am J Pathol 166(6):1761\u20131771","journal-title":"Am J Pathol"},{"issue":"5","key":"1949_CR34","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1046\/j.1471-4159.2000.0752155.x","volume":"75","author":"M Goedert","year":"2000","unstructured":"Goedert M, Satumtira S, Jakes R, Smith MJ, Kamibayashi C, White CL III, Sontag E (2000) Reduced binding of protein phosphatase 2A to Tau protein with frontotemporal dementia and parkinsonism linked to chromosome 17 mutations. J Neurochem 75(5):2155\u20132162","journal-title":"J Neurochem"},{"key":"1949_CR35","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.neuroscience.2015.03.005","volume":"294","author":"R Li","year":"2015","unstructured":"Li R, Xu DE, Ma T (2015) Lovastatin suppresses the aberrant tau phosphorylation from FTDP-17 mutation and okadaic acid-induction in rat primary neurons. Neuroscience 294:14\u201320","journal-title":"Neuroscience"},{"issue":"4","key":"1949_CR36","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","volume":"82","author":"H Braak","year":"1991","unstructured":"Braak H, Braak E (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 82(4):239\u2013259","journal-title":"Acta Neuropathol"},{"key":"1949_CR37","author":"V Melis","year":"2014","unstructured":"Melis V, Zabke C, Stamer K, Magbagbeolu M, Schwab K, Marschall P, Veh RW, Bachmann S, Deiana S, Moreau P, Davidson K, Harrington KA, Rickard JE, Horsley D, Garman R, Mazurkiewicz M, Niewiadomska G, Wischik CM, Harrington CR, Riedel G, Theuring F (2014) Different pathways of molecular pathophysiology underlie cognitive and motor tauopathy phenotypes in transgenic models for Alzheimer\u2019s disease and frontotemporal lobar degeneration. Cell Mol Life Sci CMLS. doi: 10.1007\/s00018-014-1804-z","journal-title":"Cell Mol Life Sci CMLS"},{"issue":"4","key":"1949_CR38","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1002\/ana.22615","volume":"70","author":"M Jucker","year":"2011","unstructured":"Jucker M, Walker LC (2011) Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders. Ann Neurol 70(4):532\u2013540","journal-title":"Ann Neurol"},{"issue":"27","key":"1949_CR39","doi-asserted-by":"crossref","first-page":"11025","DOI":"10.1073\/pnas.1206555109","volume":"109","author":"J Stohr","year":"2012","unstructured":"Stohr J, Watts JC, Mensinger ZL, Oehler A, Grillo SK, Dearmond SJ, Prusiner SB, Giles K (2012) Purified and synthetic Alzheimer\u2019s amyloid beta (Abeta) prions. Proc Natl Acad Sci USA 109(27):11025\u201311030","journal-title":"Proc Natl Acad Sci USA"},{"issue":"7","key":"1949_CR40","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1038\/ncb1901","volume":"11","author":"F Clavaguera","year":"2009","unstructured":"Clavaguera F, Bolmont T, Crowther RA, Abramowski D, Frank S, Probst A, Fraser G, Stalder AK, Beibel M, Staufenbiel M, Jucker M, Goedert M, Tolnay M (2009) Transmission and spreading of tauopathy in transgenic mouse brain. Nat Cell Biol 11(7):909\u2013913","journal-title":"Nat Cell Biol"},{"issue":"3","key":"1949_CR41","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.neuron.2007.01.010","volume":"53","author":"Y Yoshiyama","year":"2007","unstructured":"Yoshiyama Y, Higuchi M, Zhang B, Huang SM, Iwata N, Saido TC, Maeda J, Suhara T, Trojanowski JQ, Lee VM (2007) Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron 53(3):337\u2013351","journal-title":"Neuron"},{"key":"1949_CR42","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.nbd.2014.08.032","volume":"73","author":"E Peeraer","year":"2015","unstructured":"Peeraer E, Bottelbergs A, Van Kolen K, Stancu IC, Vasconcelos B, Mahieu M, Duytschaever H, Ver Donck L, Torremans A, Sluydts E, Van Acker N, Kemp JA, Mercken M, Brunden KR, Trojanowski JQ, Dewachter I, Lee VM, Moechars D (2015) Intracerebral injection of preformed synthetic Tau fibrils initiates widespread tauopathy and neuronal loss in the brains of Tau transgenic mice. Neurobiol Dis 73:83\u201395","journal-title":"Neurobiol Dis"},{"key":"1949_CR43","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/2051-5960-2-14","volume":"2","author":"S Dujardin","year":"2014","unstructured":"Dujardin S, Lecolle K, Caillierez R, Begard S, Zommer N, Lachaud C, Carrier S, Dufour N, Auregan G, Winderickx J, Hantraye P, Deglon N, Colin M, Buee L (2014) Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies. Acta Neuropathol Commun 2:14","journal-title":"Acta Neuropathol Commun"},{"key":"1949_CR44","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1750-1326-8-37","volume":"8","author":"S Do Carmo","year":"2013","unstructured":"Do Carmo S, Cuello AC (2013) Modeling Alzheimer\u2019s disease in transgenic rats. Mol Neurodegener 8:37","journal-title":"Mol Neurodegener"},{"issue":"10","key":"1949_CR45","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/S0090-9556(25)06742-X","volume":"23","author":"JH Lin","year":"1995","unstructured":"Lin JH (1995) Species similarities and differences in pharmacokinetics. Drug metabolism and disposition: the biological fate of chemicals 23(10):1008\u20131021","journal-title":"Drug metabolism and disposition: the biological fate of chemicals"},{"issue":"1","key":"1949_CR46","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nrg702","volume":"3","author":"HJ Jacob","year":"2002","unstructured":"Jacob HJ, Kwitek AE (2002) Rat genetics: attaching physiology and pharmacology to the genome. Nat Rev Genet 3(1):33\u201342","journal-title":"Nat Rev Genet"},{"issue":"6","key":"1949_CR47","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1002\/cne.21867","volume":"511","author":"P McMillan","year":"2008","unstructured":"McMillan P, Korvatska E, Poorkaj P, Evstafjeva Z, Robinson L, Greenup L, Leverenz J, Schellenberg GD, D\u2019Souza I (2008) Tau isoform regulation is region- and cell-specific in mouse brain. J Comp Neurol 511(6):788\u2013803","journal-title":"J Comp Neurol"},{"issue":"5","key":"1949_CR48","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1111\/j.1471-4159.2009.05869.x","volume":"108","author":"J Hanes","year":"2009","unstructured":"Hanes J, Zilka N, Bartkova M, Caletkova M, Dobrota D, Novak M (2009) Rat Tau proteome consists of six Tau isoforms: implication for animal models of human tauopathies. J Neurochem 108(5):1167\u20131176","journal-title":"J Neurochem"},{"issue":"1","key":"1949_CR49","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0165-0173(00)00019-9","volume":"33","author":"L Buee","year":"2000","unstructured":"Buee L, Bussiere T, Buee-Scherrer V, Delacourte A, Hof PR (2000) Tau protein isoforms, phosphorylation and role in neurodegenerative disorders. Brain Res Brain Res Rev 33(1):95\u2013130","journal-title":"Brain Res Brain Res Rev"},{"issue":"4","key":"1949_CR50","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s004010050622","volume":"93","author":"E Braak","year":"1997","unstructured":"Braak E, Braak H (1997) Alzheimer\u2019s disease: transiently developing dendritic changes in pyramidal cells of sector CA1 of the Ammon\u2019s horn. Acta Neuropathol 93(4):323\u2013325","journal-title":"Acta Neuropathol"},{"issue":"10","key":"1949_CR51","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1107\/S1744309112030382","volume":"68","author":"O Cehlar","year":"2012","unstructured":"Cehlar O, Skrabana R, Kovac A, Kovacech B, Novak M (2012) Crystallization and preliminary X-ray diffraction analysis of Tau protein microtubule-binding motifs in complex with Tau5 and DC25 antibody Fab fragments. Acta Crystallogr Sect F Struct Biol Cryst Commun 68(10):1181\u20131185","journal-title":"Acta Crystallogr Sect F Struct Biol Cryst Commun"},{"issue":"1","key":"1949_CR52","first-page":"47","volume":"117","author":"K Sepcic","year":"1997","unstructured":"Sepcic K, Batista U, Vacelet J, Macek P, Turk T (1997) Biological activities of aqueous extracts from marine sponges and cytotoxic effects of 3-alkylpyridinium polymers from Reniera sarai Comparative biochemistry and physiologyPart C. Pharmacol Toxicol Endocrinol 117(1):47\u201353","journal-title":"Pharmacol Toxicol Endocrinol"},{"issue":"8","key":"1949_CR53","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1038\/sj.bjp.0705374","volume":"139","author":"D McClelland","year":"2003","unstructured":"McClelland D, Evans RM, Abidin I, Sharma S, Choudhry FZ, Jaspars M, Sepcic K, Scott RH (2003) Irreversible and reversible pore formation by polymeric alkylpyridinium salts (poly-APS) from the sponge Reniera sarai. Br J Pharmacol 139(8):1399\u20131408","journal-title":"Br J Pharmacol"},{"issue":"2","key":"1949_CR54","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0005-2736(03)00175-5","volume":"1614","author":"SJ Tucker","year":"2003","unstructured":"Tucker SJ, McClelland D, Jaspars M, Sepcic K, Macewan DJ, Scott RH (2003) The influence of alkyl pyridinium sponge toxins on membrane properties, cytotoxicity, transfection and protein expression in mammalian cells. Biochim Biophys Acta 1614(2):171\u2013181","journal-title":"Biochim Biophys Acta"},{"key":"1949_CR55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2210-7-1","volume":"7","author":"DJ Koss","year":"2007","unstructured":"Koss DJ, Hindley KP, David KC, Mancini I, Guella G, Sepcic K, Turk T, Rebolj K, Riedel G, Platt B, Scott RH (2007) A comparative study of the actions of alkylpyridinium salts from a marine sponge and related synthetic compounds in rat cultured hippocampal neurones. BMC Pharmacol 7:1","journal-title":"BMC Pharmacol"},{"issue":"2","key":"1949_CR56","first-page":"221","volume":"124","author":"P Malovrh","year":"1999","unstructured":"Malovrh P, Sepcic K, Turk T, Macek P (1999) Characterization of hemolytic activity of 3-alkylpyridinium polymers from the marine sponge Reniera sarai Comparative biochemistry and physiologyPart C. Pharmacol Toxicol Endocrinol 124(2):221\u2013226","journal-title":"Pharmacol Toxicol Endocrinol"},{"key":"1949_CR57","doi-asserted-by":"crossref","first-page":"3916","DOI":"10.1021\/jo00414a026","volume":"43","author":"FJ Schmitz","year":"1978","unstructured":"Schmitz FJ, Hollenbeak KH, Campbell DC (1978) Marine natural products: halitoxin, toxic complex of several marine sponges of the genus Haliclona. J Org Chem 43:3916\u20133922","journal-title":"J Org Chem"},{"issue":"2","key":"1949_CR58","first-page":"155","volume":"115","author":"RG Berlinck","year":"1996","unstructured":"Berlinck RG, Ogawa CA, Almeida AM, Sanchez MA, Malpezzi EL, Costa LV, Hajdu E, De Freitas JC (1996) Chemical and pharmacological characterization of halitoxin from Amphimedon viridis (Porifera) from the southeastern Brazilian coast Comparative biochemistry and physiology Part C. Pharmacol Toxicol Endocrinol 115(2):155\u2013163","journal-title":"Pharmacol Toxicol Endocrinol"},{"issue":"2","key":"1949_CR59","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s002320001078","volume":"176","author":"RH Scott","year":"2000","unstructured":"Scott RH, Whyment AD, Foster A, Gordon KH, Milne BF, Jaspars M (2000) Analysis of the structure and electrophysiological actions of halitoxins: 1,3 alkyl-pyridinium salts from Callyspongia ridleyi. J Membr Biol 176(2):119\u2013131","journal-title":"J Membr Biol"},{"issue":"10","key":"1949_CR60","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1021\/np970292q","volume":"60","author":"K Sepcic","year":"1997","unstructured":"Sepcic K, Guella G, Mancini I, Pietra F, Serra MD, Menestrina G, Tubbs K, Macek P, Turk T (1997) Characterization of anticholinesterase-active 3-alkylpyridinium polymers from the marine sponge Reniera sarai in aqueous solutions. J Nat Prod 60(10):991\u2013996","journal-title":"J Nat Prod"},{"key":"1949_CR61","doi-asserted-by":"crossref","first-page":"5925","DOI":"10.1021\/jo00074a017","volume":"58","author":"MT Davies-Coleman","year":"1993","unstructured":"Davies-Coleman MT, Faulkner DJ, Dubowchik GM, Roth GP, Polson C, Fairchild C (1993) A New EGF-Active Polymeric Pyridinium Alkaloid from the Sponge Callyspongia fibrosa. J Org Chem 58:5925\u20135930","journal-title":"J Org Chem"},{"issue":"4","key":"1949_CR62","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1111\/j.1471-4159.2007.04579.x","volume":"102","author":"DJ Koss","year":"2007","unstructured":"Koss DJ, Hindley KP, Riedel G, Platt B (2007) Modulation of hippocampal calcium signalling and plasticity by serine\/threonine protein phosphatases. J Neurochem 102(4):1009\u20131023","journal-title":"J Neurochem"},{"issue":"1","key":"1949_CR63","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ceca.2009.04.001","volume":"46","author":"DJ Koss","year":"2009","unstructured":"Koss DJ, Riedel G, Platt B (2009) Intracellular Ca2\u00a0+\u00a0stores modulate SOCCs and NMDA receptors via tyrosine kinases in rat hippocampal neurons. Cell Calcium 46(1):39\u201348","journal-title":"Cell Calcium"},{"issue":"24","key":"1949_CR64","doi-asserted-by":"crossref","first-page":"9488","DOI":"10.1073\/pnas.83.24.9488","volume":"83","author":"BF Scharschmidt","year":"1986","unstructured":"Scharschmidt BF, Lake JR, Renner EL, Licko V, van Dyke RW (1986) Fluid phase endocytosis by cultured rat hepatocytes and perfused rat liver: implications for plasma membrane turnover and vesicular trafficking of fluid phase markers. Proc Natl Acad Sci USA 83(24):9488\u20139492","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"1949_CR65","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/BF00656997","volume":"391","author":"OP Hamill","year":"1981","unstructured":"Hamill OP, Marty A, Neher E, Sakmann B, Sigworth FJ (1981) Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch 391(2):85\u2013100","journal-title":"Pflugers Arch"},{"issue":"10","key":"1949_CR66","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1038\/13202","volume":"2","author":"G Riedel","year":"1999","unstructured":"Riedel G, Micheau J, Lam AG, Roloff EL, Martin SJ, Bridge H, de Hoz L, Poeschel B, McCulloch J, Morris RG (1999) Reversible neural inactivation reveals hippocampal participation in several memory processes. Nat Neurosci 2(10):898\u2013905","journal-title":"Nat Neurosci"},{"issue":"4","key":"1949_CR67","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s00213-007-1012-8","volume":"198","author":"L Robinson","year":"2008","unstructured":"Robinson L, McKillop-Smith S, Ross NL, Pertwee RG, Hampson RE, Platt B, Riedel G (2008) Hippocampal endocannabinoids inhibit spatial learning and limit spatial memory in rats. Psychopharmacology 198(4):551\u2013563","journal-title":"Psychopharmacology"},{"issue":"2","key":"1949_CR68","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.neulet.2004.09.072","volume":"373","author":"LA Christie","year":"2005","unstructured":"Christie LA, Riedel G, Algaidi SA, Whalley LJ, Platt B (2005) Enhanced hippocampal long-term potentiation in rats after chronic exposure to homocysteine. Neurosci Lett 373(2):119\u2013124","journal-title":"Neurosci Lett"},{"issue":"14","key":"1949_CR69","first-page":"1273","volume":"70","author":"DJ Koss","year":"2013","unstructured":"Koss DJ, Drever BD, Stoppelkamp S, Riedel G, Platt B (2013) Age-dependent changes in hippocampal synaptic transmission and plasticity in the PLB1(Triple) Alzheimer mouse. Cellular and molecular life sciences : CMLS 70(14):1273\u20131279","journal-title":"Cellular and molecular life sciences : CMLS"},{"issue":"1","key":"1949_CR70","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.expneurol.2005.07.003","volume":"197","author":"SA Algaidi","year":"2006","unstructured":"Algaidi SA, Christie LA, Jenkinson AM, Whalley L, Riedel G, Platt B (2006) Long-term homocysteine exposure induces alterations in spatial learning, hippocampal signalling and synaptic plasticity. Exp Neurol 197(1):8\u201321","journal-title":"Exp Neurol"},{"issue":"6","key":"1949_CR71","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1515\/REVNEURO.2006.17.6.581","volume":"17","author":"G Niewiadomska","year":"2006","unstructured":"Niewiadomska G, Baksalerska-Pazera M, Riedel G (2006) Cytoskeletal transport in the aging brain: focus on the cholinergic system. Rev Neurosci 17(6):581\u2013618","journal-title":"Rev Neurosci"},{"issue":"4","key":"1949_CR72","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/S0306-4522(97)00695-7","volume":"85","author":"AK Mudher","year":"1998","unstructured":"Mudher AK, Perry VH (1998) Using okadaic acid as a tool for the in vivo induction of hyperphosphorylated Tau. Neuroscience 85(4):1329\u20131332","journal-title":"Neuroscience"},{"issue":"4","key":"1949_CR73","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/S0306-4522(97)00696-9","volume":"85","author":"AM Dam van","year":"1998","unstructured":"van Dam AM, Bol JG, Binnekade R, van Muiswinkel FL (1998) Acute or chronic administration of okadaic acid to rats induces brain damage rather than Alzheimer-like neuropathology. Neuroscience 85(4):1333\u20131335","journal-title":"Neuroscience"},{"issue":"2","key":"1949_CR74","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.expneurol.2011.12.002","volume":"233","author":"RD Dayton","year":"2012","unstructured":"Dayton RD, Wang DB, Cain CD, Schrott LM, Ramirez JJ, King MA, Klein RL (2012) Frontotemporal lobar degeneration-related proteins induce only subtle memory-related deficits when bilaterally overexpressed in the dorsal hippocampus. Exp Neurol 233(2):807\u2013814","journal-title":"Exp Neurol"},{"issue":"2","key":"1949_CR75","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.neuron.2013.07.046","volume":"80","author":"K Yanamandra","year":"2013","unstructured":"Yanamandra K, Kfoury N, Jiang H, Mahan TE, Ma S, Maloney SE, Wozniak DF, Diamond MI, Holtzman DM (2013) Anti-Tau antibodies that block Tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo. Neuron 80(2):402\u2013414","journal-title":"Neuron"},{"key":"1949_CR76","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1472-6750-6-6","volume":"6","author":"D McLaggan","year":"2006","unstructured":"McLaggan D, Adjimatera N, Sepcic K, Jaspars M, Macewan DJ, Blagbrough IS, Scott RH (2006) Pore forming polyalkylpyridinium salts from marine sponges versus synthetic lipofection systems: distinct tools for intracellular delivery of cDNA and siRNA. BMC Biotechnol 6:6","journal-title":"BMC Biotechnol"},{"issue":"6","key":"1949_CR77","first-page":"1381","volume":"29","author":"L Paleari","year":"2006","unstructured":"Paleari L, Trombino S, Falugi C, Gallus L, Carlone S, Angelini C, Sepcic K, Turk T, Faimali M, Noonan DM, Albini A (2006) Marine sponge-derived polymeric alkylpyridinium salts as a novel tumor chemotherapeutic targeting the cholinergic system in lung tumors. Int J Oncol 29(6):1381\u20131388","journal-title":"Int J Oncol"},{"issue":"Pt 9","key":"1949_CR78","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.mycres.2008.03.009","volume":"112","author":"S Berne","year":"2008","unstructured":"Berne S, Pohleven F, Turk T, Sepcic K (2008) Induction of fruiting in oyster mushroom (Pleurotus ostreatus) by polymeric 3-alkylpyridinium salts. Mycol Res 112(Pt 9):1085\u20131087","journal-title":"Mycol Res"},{"issue":"2","key":"1949_CR79","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1080\/08927010801935745","volume":"24","author":"T Elersek","year":"2008","unstructured":"Elersek T, Kosi G, Turk T, Pohleven F, Sepcic K (2008) Influence of polymeric 3-alkylpyridinium salts from the marine sponge Reniera sarai on the growth of algae and wood decay fungi. Biofouling 24(2):137\u2013143","journal-title":"Biofouling"},{"key":"1949_CR80","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.tox.2012.10.013","volume":"303","author":"M Grandic","year":"2013","unstructured":"Grandic M, Araoz R, Molgo J, Turk T, Sepcic K, Benoit E, Frangez R (2013) Toxicity of the synthetic polymeric 3-alkylpyridinium salt (APS3) is due to specific block of nicotinic acetylcholine receptors. Toxicology 303:25\u201333","journal-title":"Toxicology"},{"issue":"4","key":"1949_CR81","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3390\/MD504157","volume":"5","author":"T Turk","year":"2007","unstructured":"Turk T, Frangez R, Sepcic K (2007) Mechanisms of toxicity of 3-alkylpyridinium polymers from marine sponge Reniera sarai. Marine drugs 5(4):157\u2013167","journal-title":"Marine drugs"},{"issue":"2","key":"1949_CR82","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0304-3940(90)90028-8","volume":"120","author":"T Yamada","year":"1990","unstructured":"Yamada T, McGeer PL (1990) Oligodendroglial microtubular masses: an abnormality observed in some human neurodegenerative diseases. Neurosci Lett 120(2):163\u2013166","journal-title":"Neurosci Lett"},{"issue":"5","key":"1949_CR83","first-page":"1052","volume":"146","author":"M Nishimura","year":"1995","unstructured":"Nishimura M, Tomimoto H, Suenaga T, Namba Y, Ikeda K, Akiguchi I, Kimura J (1995) Immunocytochemical characterization of glial fibrillary tangles in Alzheimer\u2019s disease brain. Am J Pathol 146(5):1052\u20131058","journal-title":"Am J Pathol"},{"issue":"1","key":"1949_CR84","first-page":"283","volume":"256","author":"C Bialojan","year":"1988","unstructured":"Bialojan C, Takai A (1988) Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics. The Biochemical journal 256(1):283\u2013290","journal-title":"Specificity and kinetics. The Biochemical journal"},{"issue":"7","key":"1949_CR85","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0968-0004(97)01060-8","volume":"22","author":"PT Cohen","year":"1997","unstructured":"Cohen PT (1997) Novel protein serine\/threonine phosphatases: variety is the spice of life. Trends Biochem Sci 22(7):245\u2013251","journal-title":"Trends Biochem Sci"},{"issue":"3","key":"1949_CR86","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0014-5793(01)02177-9","volume":"491","author":"EB Borthwick","year":"2001","unstructured":"Borthwick EB, Zeke T, Prescott AR, Cohen PT (2001) Nuclear localization of protein phosphatase 5 is dependent on the carboxy-terminal region. FEBS Lett 491(3):279\u2013284","journal-title":"FEBS Lett"},{"issue":"5","key":"1949_CR87","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/(SICI)1097-4547(19970601)48:5<425::AID-JNR4>3.0.CO;2-G","volume":"48","author":"F Malchiodi-Albedi","year":"1997","unstructured":"Malchiodi-Albedi F, Petrucci TC, Picconi B, Iosi F, Falchi M (1997) Protein phosphatase inhibitors induce modification of synapse structure and Tau hyperphosphorylation in cultured rat hippocampal neurons. J Neurosci Res 48(5):425\u2013438","journal-title":"J Neurosci Res"},{"issue":"2","key":"1949_CR88","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0006-8993(99)01724-2","volume":"839","author":"D Kim","year":"1999","unstructured":"Kim D, Su J, Cotman CW (1999) Sequence of neurodegeneration and accumulation of phosphorylated Tau in cultured neurons after okadaic acid treatment. Brain Res 839(2):253\u2013262","journal-title":"Brain Res"},{"issue":"2","key":"1949_CR89","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/S0014-5793(98)00346-9","volume":"426","author":"T Tanaka","year":"1998","unstructured":"Tanaka T, Zhong J, Iqbal K, Trenkner E, Grundke-Iqbal I (1998) The regulation of phosphorylation of Tau in SY5Y neuroblastoma cells: the role of protein phosphatases. FEBS Lett 426(2):248\u2013254","journal-title":"FEBS Lett"},{"issue":"2","key":"1949_CR90","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1046\/j.1471-4159.2003.02020.x","volume":"87","author":"K Furukawa","year":"2003","unstructured":"Furukawa K, Wang Y, Yao PJ, Fu W, Mattson MP, Itoyama Y, Onodera H, D\u2019Souza I, Poorkaj PH, Bird TD, Schellenberg GD (2003) Alteration in calcium channel properties is responsible for the neurotoxic action of a familial frontotemporal dementia Tau mutation. J Neurochem 87(2):427\u2013436","journal-title":"J Neurochem"},{"issue":"2","key":"1949_CR91","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.expneurol.2011.01.018","volume":"229","author":"S Stoppelkamp","year":"2011","unstructured":"Stoppelkamp S, Bell HS, Palacios-Filardo J, Shewan DA, Riedel G, Platt B (2011) In vitro modelling of Alzheimer\u2019s disease: degeneration and cell death induced by viral delivery of amyloid and Tau. Exp Neurol 229(2):226\u2013237","journal-title":"Exp Neurol"},{"issue":"12","key":"1949_CR92","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.tins.2014.08.004","volume":"37","author":"H Zempel","year":"2014","unstructured":"Zempel H, Mandelkow E (2014) Lost after translation: missorting of Tau protein and consequences for Alzheimer disease. Trends Neurosci 37(12):721\u2013732","journal-title":"Trends Neurosci"},{"issue":"2","key":"1949_CR93","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1006\/nbdi.1999.0279","volume":"7","author":"K Duff","year":"2000","unstructured":"Duff K, Knight H, Refolo LM, Sanders S, Yu X, Picciano M, Malester B, Hutton M, Adamson J, Goedert M, Burki K, Davies P (2000) Characterization of pathology in transgenic mice over-expressing human genomic and cDNA Tau transgenes. Neurobiology of disease 7(2):87\u201398","journal-title":"Neurobiology of disease"},{"issue":"3","key":"1949_CR94","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1046\/j.1471-4159.2003.01879.x","volume":"86","author":"C Andorfer","year":"2003","unstructured":"Andorfer C, Kress Y, Espinoza M, de Silva R, Tucker KL, Barde YA, Duff K, Davies P (2003) Hyperphosphorylation and aggregation of Tau in mice expressing normal human Tau isoforms. J Neurochem 86(3):582\u2013590","journal-title":"J Neurochem"},{"issue":"34","key":"1949_CR95","doi-asserted-by":"crossref","first-page":"10741","DOI":"10.1523\/JNEUROSCI.1065-09.2009","volume":"29","author":"M Polydoro","year":"2009","unstructured":"Polydoro M, Acker CM, Duff K, Castillo PE, Davies P (2009) Age-dependent impairment of cognitive and synaptic function in the htau mouse model of Tau pathology. The Journal of neuroscience : the official journal of the Society for Neuroscience 29(34):10741\u201310749","journal-title":"The Journal of neuroscience : the official journal of the Society for Neuroscience"},{"issue":"1","key":"1949_CR96","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.mcn.2011.09.002","volume":"49","author":"PJ Khandelwal","year":"2012","unstructured":"Khandelwal PJ, Dumanis SB, Herman AM, Rebeck GW, Moussa CE (2012) Wild type and P301L mutant Tau promote neuro-inflammation and alpha-Synuclein accumulation in lentiviral gene delivery models. Molecular and cellular neurosciences 49(1):44\u201353","journal-title":"Molecular and cellular neurosciences"},{"issue":"2","key":"1949_CR97","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.expneurol.2011.12.002","volume":"233","author":"RD Dayton","year":"2012","unstructured":"Dayton RD, Wang DB, Cain CD, Schrott LM, Ramirez JJ, King MA, Klein RL (2012) Frontotemporal lobar degeneration-related proteins induce only subtle memory-related deficits when bilaterally overexpressed in the dorsal hippocampus. Exp Neurol 233(2):807\u2013814","journal-title":"Exp Neurol"},{"issue":"7","key":"1949_CR98","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1038\/mt.2013.66","volume":"21","author":"R Caillierez","year":"2013","unstructured":"Caillierez R, Begard S, Lecolle K, Deramecourt V, Zommer N, Dujardin S, Loyens A, Dufour N, Auregan G, Winderickx J, Hantraye P, Deglon N, Buee L, Colin M (2013) Lentiviral delivery of the human wild-type Tau protein mediates a slow and progressive neurodegenerative Tau pathology in the rat brain. Molecular therapy : the journal of the American Society of Gene Therapy 21(7):1358\u20131368","journal-title":"Molecular therapy : the journal of the American Society of Gene Therapy"},{"key":"1949_CR99","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/2051-5960-2-14","volume":"2","author":"S Dujardin","year":"2014","unstructured":"Dujardin S, Lecolle K, Caillierez R, Begard S, Zommer N, Lachaud C, Carrier S, Dufour N, Auregan G, Winderickx J, Hantraye P, Deglon N, Colin M, Buee L (2014) Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism relevance to sporadic tauopathies. Acta Neuropathol Commun 2:14","journal-title":"Acta Neuropathol Commun"},{"issue":"12","key":"1949_CR100","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1007\/s007020100018","volume":"108","author":"J He","year":"2001","unstructured":"He J, Yamada K, Zou LB, Nabeshima T (2001) Spatial memory deficit and neurodegeneration induced by the direct injection of okadaic acid into the hippocampus in rats. J Neural Transm Vienna Austria 108(12):1435\u20131443","journal-title":"J Neural Transm Vienna Austria"},{"issue":"4","key":"1949_CR101","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/S0306-4522(02)00697-8","volume":"118","author":"L Sun","year":"2003","unstructured":"Sun L, Liu SY, Zhou XW, Wang XC, Liu R, Wang Q, Wang JZ (2003) Inhibition of protein phosphatase 2A- and protein phosphatase 1-induced Tau hyperphosphorylation and impairment of spatial memory retention in rats. Neuroscience 118(4):1175\u20131182","journal-title":"Neuroscience"},{"issue":"8","key":"1949_CR102","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1038\/sj.npp.1300757","volume":"30","author":"J He","year":"2005","unstructured":"He J, Yang Y, Xu H, Zhang X, Li XM (2005) Olanzapine attenuates the okadaic acid-induced spatial memory impairment and hippocampal cell death in rats. Neuropsychopharmacol Off Publ Am Coll Neuropsychopharmacol 30(8):1511\u20131520","journal-title":"Neuropsychopharmacol Off Publ Am Coll Neuropsychopharmacol"},{"issue":"3","key":"1949_CR103","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/0306-4522(95)00347-L","volume":"69","author":"T Arendt","year":"1995","unstructured":"Arendt T, Holzer M, Fruth R, Bruckner MK, Gartner U (1995) Paired helical filament-like phosphorylation of Tau, deposition of beta\/A4-amyloid and memory impairment in rat induced by chronic inhibition of phosphatase 1 and 2A. Neuroscience 69(3):691\u2013698","journal-title":"Neuroscience"},{"issue":"5","key":"1949_CR104","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/S0968-0004(99)01375-4","volume":"24","author":"TA Millward","year":"1999","unstructured":"Millward TA, Zolnierowicz S, Hemmings BA (1999) Regulation of protein kinase cascades by protein phosphatase 2A. Trends Biochem Sci 24(5):186\u2013191","journal-title":"Trends Biochem Sci"},{"issue":"1","key":"1949_CR105","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1152\/physrev.2000.80.1.173","volume":"80","author":"S Herzig","year":"2000","unstructured":"Herzig S, Neumann J (2000) Effects of serine\/threonine protein phosphatases on ion channels in excitable membranes. Physiol Rev 80(1):173\u2013210","journal-title":"Physiol Rev"},{"key":"1949_CR106","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.brainres.2010.08.077","volume":"1359","author":"Z Zhang","year":"2010","unstructured":"Zhang Z, Simpkins JW (2010) An okadaic acid-induced model of tauopathy and cognitive deficiency. Brain Res 1359:233\u2013246","journal-title":"Brain Res"},{"issue":"2","key":"1949_CR107","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1111\/j.1471-4159.1992.tb09432.x","volume":"59","author":"S Khatoon","year":"1992","unstructured":"Khatoon S, Grundke-Iqbal I, Iqbal K (1992) Brain levels of microtubule-associated protein Tau are elevated in Alzheimer\u2019s disease: a radioimmuno-slot-blot assay for nanograms of the protein. J Neurochem 59(2):750\u2013753","journal-title":"J Neurochem"},{"issue":"1","key":"1949_CR108","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/0014-5793(94)00829-9","volume":"351","author":"S Khatoon","year":"1994","unstructured":"Khatoon S, Grundke-Iqbal I, Iqbal K (1994) Levels of normal and abnormally phosphorylated Tau in different cellular and regional compartments of Alzheimer disease and control brains. FEBS Lett 351(1):80\u201384","journal-title":"FEBS Lett"},{"issue":"2","key":"1949_CR109","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/0306-4522(94)90546-0","volume":"63","author":"M Holzer","year":"1994","unstructured":"Holzer M, Holzapfel HP, Zedlick D, Bruckner MK, Arendt T (1994) Abnormally phosphorylated Tau protein in Alzheimer\u2019s disease: heterogeneity of individual regional distribution and relationship to clinical severity. Neuroscience 63(2):499\u2013516","journal-title":"Neuroscience"},{"issue":"1","key":"1949_CR110","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1006\/exnr.2000.7380","volume":"163","author":"DR Thal","year":"2000","unstructured":"Thal DR, Holzer M, Rub U, Waldmann G, Gunzel S, Zedlick D, Schober R (2000) Alzheimer-related Tau-pathology in the perforant path target zone and in the hippocampal stratum oriens and radiatum correlates with onset and degree of dementia. Exp Neurol 163(1):98\u2013110","journal-title":"Exp Neurol"},{"issue":"1","key":"1949_CR111","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jalz.2013.12.024","volume":"11","author":"X Wang","year":"2015","unstructured":"Wang X, Zhu M, Hjorth E, Cortes-Toro V, Eyjolfsdottir H, Graff C, Nennesmo I, Palmblad J, Eriksdotter M, Sambamurti K, Fitzgerald JM, Serhan CN, Granholm AC, Schultzberg M (2015) Resolution of inflammation is altered in Alzheimer\u2019s disease. Alzheimer\u2019s Dement J Alzheimer\u2019s Assoc 11(1):40\u201350","journal-title":"Alzheimer\u2019s Dement J Alzheimer\u2019s Assoc"},{"issue":"1\u20132","key":"1949_CR112","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0304-3940(93)90590-H","volume":"162","author":"C Bancher","year":"1993","unstructured":"Bancher C, Braak H, Fischer P, Jellinger KA (1993) Neuropathological staging of Alzheimer lesions and intellectual status in Alzheimer\u2019s and Parkinson\u2019s disease patients. Neurosci Lett 162(1\u20132):179\u2013182","journal-title":"Neurosci Lett"},{"issue":"1","key":"1949_CR113","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/0278-2626(89)90009-2","volume":"11","author":"M Freedman","year":"1989","unstructured":"Freedman M, Oscar-Berman M (1989) Spatial and visual learning deficits in Alzheimer\u2019s and Parkinson\u2019s disease. Brain Cogn 11(1):114\u2013126","journal-title":"Brain Cogn"},{"issue":"12","key":"1949_CR114","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1586\/14737175.8.12.1879","volume":"8","author":"CA Gold","year":"2008","unstructured":"Gold CA, Budson AE (2008) Memory loss in Alzheimer\u2019s disease: implications for development of therapeutics. Expert Rev Neurother 8(12):1879\u20131891","journal-title":"Expert Rev Neurother"},{"issue":"5790","key":"1949_CR115","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1126\/science.1128134","volume":"313","author":"JR Whitlock","year":"2006","unstructured":"Whitlock JR, Heynen AJ, Shuler MG, Bear MF (2006) Learning induces long-term potentiation in the hippocampus. Science (New York, NY) 313(5790):1093\u20131097","journal-title":"Science (New York, NY)"},{"issue":"7509","key":"1949_CR116","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/nature13294","volume":"511","author":"S Nabavi","year":"2014","unstructured":"Nabavi S, Fox R, Proulx CD, Lin JY, Tsien RY, Malinow R (2014) Engineering a memory with LTD and LTP. Nature 511(7509):348\u2013352","journal-title":"Nature"},{"issue":"3","key":"1949_CR117","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0896-6273(03)00434-3","volume":"39","author":"S Oddo","year":"2003","unstructured":"Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, Metherate R, Mattson MP, Akbari Y, Laferla FM (2003) Triple-transgenic model of Alzheimer\u2019s disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron 39(3):409\u2013421","journal-title":"Neuron"},{"issue":"1","key":"1949_CR118","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.expneurol.2008.03.007","volume":"212","author":"H Rosenmann","year":"2008","unstructured":"Rosenmann H, Grigoriadis N, Eldar-Levy H, Avital A, Rozenstein L, Touloumi O, Behar L, Ben-Hur T, Avraham Y, Berry E, Segal M, Ginzburg I, Abramsky O (2008) A novel transgenic mouse expressing double mutant Tau driven by its natural promoter exhibits tauopathy characteristics. Exp Neurol 212(1):71\u201384","journal-title":"Exp Neurol"},{"issue":"1","key":"1949_CR119","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3233\/JAD-122296","volume":"37","author":"AC Lo","year":"2013","unstructured":"Lo AC, Iscru E, Blum D, Tesseur I, Callaerts-Vegh Z, Buee L, de Strooper B, Balschun D, D\u2019Hooge R (2013) Amyloid and Tau neuropathology differentially affect prefrontal synaptic plasticity and cognitive performance in mouse models of Alzheimer\u2019s disease. J Alzheimer\u2019s Dis JAD 37(1):109\u2013125","journal-title":"J Alzheimer\u2019s Dis JAD"},{"issue":"11","key":"1949_CR120","doi-asserted-by":"crossref","first-page":"e27068","DOI":"10.1371\/journal.pone.0027068","volume":"6","author":"B Platt","year":"2011","unstructured":"Platt B, Drever B, Koss D, Stoppelkamp S, Jyoti A, Plano A, Utan A, Merrick G, Ryan D, Melis V, Wan H, Mingarelli M, Porcu E, Scrocchi L, Welch A, Riedel G (2011) Abnormal cognition, sleep, EEG and brain metabolism in a novel knock-in Alzheimer mouse, PLB1. PLoS One 6(11):e27068","journal-title":"PLoS One"},{"issue":"14","key":"1949_CR121","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1007\/s00018-013-1314-4","volume":"70","author":"D Ryan","year":"2013","unstructured":"Ryan D, Koss D, Porcu E, Woodcock H, Robinson L, Platt B, Riedel G (2013) Spatial learning impairments in PLB1Triple knock-in Alzheimer mice are task-specific and age-dependent. Cell Mol life Sci CMLS 70(14):2603\u20132619","journal-title":"Cell Mol life Sci CMLS"},{"issue":"5","key":"1949_CR122","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/sj.bjp.0707273","volume":"151","author":"L Robinson","year":"2007","unstructured":"Robinson L, Goonawardena AV, Pertwee RG, Hampson RE, Riedel G (2007) The synthetic cannabinoid HU210 induces spatial memory deficits and suppresses hippocampal firing rate in rats. Br J Pharmacol 151(5):688\u2013700","journal-title":"Br J Pharmacol"},{"issue":"2","key":"1949_CR123","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.bbr.2010.01.004","volume":"208","author":"L Robinson","year":"2010","unstructured":"Robinson L, Goonawardena AV, Pertwee R, Hampson RE, Platt B, Riedel G (2010) WIN55,212-2 induced deficits in spatial learning are mediated by cholinergic hypofunction. Behav Brain Res 208(2):584\u2013592","journal-title":"Behav Brain Res"},{"issue":"3","key":"1949_CR124","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s12154-010-0036-4","volume":"3","author":"WE Houssen","year":"2010","unstructured":"Houssen WE, Lu Z, Edrada-Ebel R, Chatzi C, Tucker SJ, Sepcic K, Turk T, Zovko A, Shen S, Mancini I, Scott RH, Jaspars M (2010) Chemical synthesis and biological activities of 3-alkyl pyridinium polymeric analogues of marine toxins. J Chem Biol 3(3):113\u2013125","journal-title":"J Chem Biol"},{"key":"1949_CR125","volume-title":"The Rat Brain in stereotaxic coordinates","author":"G Paxinos","year":"2013","unstructured":"Paxinos G, Watson C (2013) The Rat Brain in stereotaxic coordinates, 7th edn. Academic Press, London","edition":"7"}],"container-title":["Cellular and Molecular Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-015-1949-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00018-015-1949-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-015-1949-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T15:25:54Z","timestamp":1748445954000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00018-015-1949-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,13]]},"references-count":125,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["1949"],"URL":"https:\/\/doi.org\/10.1007\/s00018-015-1949-4","relation":{},"ISSN":["1420-682X","1420-9071"],"issn-type":[{"type":"print","value":"1420-682X"},{"type":"electronic","value":"1420-9071"}],"subject":[],"published":{"date-parts":[[2015,6,13]]}}}