{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T23:57:59Z","timestamp":1779148679861,"version":"3.51.4"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T00:00:00Z","timestamp":1479254400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100014162","name":"Queen Mary Innovation Ltd","doi-asserted-by":"crossref","award":["2012\/13"],"award-info":[{"award-number":["2012\/13"]}],"id":[{"id":"10.13039\/501100014162","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The William Harvey Research Foundation"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell. Mol. Life Sci."],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1007\/s00018-016-2419-3","type":"journal-article","created":{"date-parts":[[2016,11,17]],"date-time":"2016-11-17T07:44:26Z","timestamp":1479368666000},"page":"1335-1345","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Old drugs with new skills: fenoprofen as an allosteric enhancer at melanocortin receptor 3"],"prefix":"10.1007","volume":"74","author":[{"given":"Trinidad","family":"Montero-Melendez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel A. E.","family":"Forfar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer M.","family":"Cook","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey C.","family":"Jerman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debra L.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Perretti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,11,16]]},"reference":[{"key":"2419_CR1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2013.20","author":"T Bartfai","year":"2013","unstructured":"Bartfai T, Wang MW (2013) Positive allosteric modulators to peptide GPCRs: a promising class of drugs. Acta Pharmacol Sin. doi: 10.1038\/aps.2013.20","journal-title":"Acta Pharmacol Sin"},{"issue":"1","key":"2419_CR2","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s13311-012-0160-7","volume":"10","author":"R Berkovich","year":"2013","unstructured":"Berkovich R (2013) Treatment of acute relapses in multiple sclerosis. Neurother: J Am Soc Exp Neurother 10(1):97\u2013105. doi: 10.1007\/s13311-012-0160-7","journal-title":"Neurother: J Am Soc Exp Neurother"},{"issue":"6","key":"2419_CR3","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1038\/88423","volume":"4","author":"AA Butler","year":"2001","unstructured":"Butler AA, Marks DL, Fan W, Kuhn CM, Bartolome M, Cone RD (2001) Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat. Nat Neurosci 4(6):605\u2013611. doi: 10.1038\/88423","journal-title":"Nat Neurosci"},{"issue":"5","key":"2419_CR4","doi-asserted-by":"publisher","first-page":"R151","DOI":"10.1186\/ar2827","volume":"11","author":"F Capsoni","year":"2009","unstructured":"Capsoni F, Ongari AM, Reali E, Catania A (2009) Melanocortin peptides inhibit urate crystal-induced activation of phagocytic cells. Arthritis Res Ther 11(5):R151. doi: 10.1186\/ar2827","journal-title":"Arthritis Res Ther"},{"key":"2419_CR5","doi-asserted-by":"publisher","first-page":"1840","DOI":"10.1100\/tsw.2010.173","volume":"10","author":"A Catania","year":"2010","unstructured":"Catania A, Lonati C, Sordi A, Carlin A, Leonardi P, Gatti S (2010) The melanocortin system in control of inflammation. Sci World J 10:1840\u20131853. doi: 10.1100\/tsw.2010.173","journal-title":"Sci World J"},{"issue":"4","key":"2419_CR6","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/0196-9781(96)00037-X","volume":"17","author":"A Catania","year":"1996","unstructured":"Catania A, Rajora N, Capsoni F, Minonzio F, Star RA, Lipton JM (1996) The neuropeptide alpha-MSH has specific receptors on neutrophils and reduces chemotaxis in vitro. Peptides 17(4):675\u2013679","journal-title":"Peptides"},{"issue":"1","key":"2419_CR7","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1159\/000097087","volume":"1","author":"G Ceriani","year":"1994","unstructured":"Ceriani G, Diaz J, Murphree S, Catania A, Lipton JM (1994) The neuropeptide alpha-melanocyte-stimulating hormone inhibits experimental arthritis in rats. Neuroimmunomodulation 1(1):28\u201332","journal-title":"Neuroimmunomodulation"},{"issue":"5","key":"2419_CR8","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1002\/art.23453","volume":"58","author":"M Chen","year":"2008","unstructured":"Chen M, Boilard E, Nigrovic PA, Clark P, Xu D, Fitzgerald GA, Audoly LP, Lee DM (2008) Predominance of cyclooxygenase 1 over cyclooxygenase 2 in the generation of proinflammatory prostaglandins in autoantibody-driven K\/BxN serum-transfer arthritis. Arthritis Rheum 58(5):1354\u20131365. doi: 10.1002\/art.23453","journal-title":"Arthritis Rheum"},{"issue":"3","key":"2419_CR9","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1038\/nrd746","volume":"1","author":"A Christopoulos","year":"2002","unstructured":"Christopoulos A (2002) Allosteric binding sites on cell-surface receptors: novel targets for drug discovery. Nat Rev Drug Discov 1(3):198\u2013210. doi: 10.1038\/nrd746","journal-title":"Nat Rev Drug Discov"},{"issue":"1","key":"2419_CR10","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.molmed.2003.11.004","volume":"10","author":"HJ Ditzel","year":"2004","unstructured":"Ditzel HJ (2004) The K\/BxN mouse: a model of human inflammatory arthritis. Trends Mol Med 10(1):40\u201345","journal-title":"Trends Mol Med"},{"issue":"1","key":"2419_CR11","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1189\/jlb.69.1.98","volume":"69","author":"SJ Getting","year":"2001","unstructured":"Getting SJ, Allcock GH, Flower R, Perretti M (2001) Natural and synthetic agonists of the melanocortin receptor type 3 possess anti-inflammatory properties. J Leukoc Biol 69(1):98\u2013104","journal-title":"J Leukoc Biol"},{"issue":"10","key":"2419_CR12","doi-asserted-by":"publisher","first-page":"2765","DOI":"10.1002\/art.10526","volume":"46","author":"SJ Getting","year":"2002","unstructured":"Getting SJ, Christian HC, Flower RJ, Perretti M (2002) Activation of melanocortin type 3 receptor as a molecular mechanism for adrenocorticotropic hormone efficacy in gouty arthritis. Arthritis Rheum 46(10):2765\u20132775. doi: 10.1002\/art.10526","journal-title":"Arthritis Rheum"},{"issue":"12","key":"2419_CR13","doi-asserted-by":"crossref","first-page":"7446","DOI":"10.4049\/jimmunol.162.12.7446","volume":"162","author":"SJ Getting","year":"1999","unstructured":"Getting SJ, Gibbs L, Clark AJ, Flower RJ, Perretti M (1999) POMC gene-derived peptides activate melanocortin type 3 receptor on murine macrophages, suppress cytokine release, and inhibit neutrophil migration in acute experimental inflammation. J Immunol 162(12):7446\u20137453","journal-title":"J Immunol"},{"issue":"13","key":"2419_CR14","doi-asserted-by":"publisher","first-page":"2234","DOI":"10.1096\/fj.06-6339com","volume":"20","author":"SJ Getting","year":"2006","unstructured":"Getting SJ, Lam CW, Chen AS, Grieco P, Perretti M (2006) Melanocortin 3 receptors control crystal-induced inflammation. FASEB J: Off Publ Fed Am Soc Exp Biol 20(13):2234\u20132241. doi: 10.1096\/fj.06-6339com","journal-title":"FASEB J: Off Publ Fed Am Soc Exp Biol"},{"issue":"6","key":"2419_CR15","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1016\/j.pupt.2008.09.004","volume":"21","author":"SJ Getting","year":"2008","unstructured":"Getting SJ, Riffo-Vasquez Y, Pitchford S, Kaneva M, Grieco P, Page CP, Perretti M, Spina D (2008) A role for MC3R in modulating lung inflammation. Pulm Pharmacol Ther 21(6):866\u2013873. doi: 10.1016\/j.pupt.2008.09.004","journal-title":"Pulm Pharmacol Ther"},{"issue":"2","key":"2419_CR16","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1038\/nrneph.2011.190","volume":"8","author":"R Gong","year":"2012","unstructured":"Gong R (2012) The renaissance of corticotropin therapy in proteinuric nephropathies. Nat Rev Nephrol 8(2):122\u2013128. doi: 10.1038\/nrneph.2011.190","journal-title":"Nat Rev Nephrol"},{"key":"2419_CR17","volume-title":"Goodman and Gilman\u2019s the pharmacological basis of therapeutics","author":"G Goodman","year":"1996","unstructured":"Goodman G, Gilman AG, Ruddon RW, Molinoff PB, Limbird L (1996) Goodman and Gilman\u2019s the pharmacological basis of therapeutics, 9th edn. McGraw-Hill, New York","edition":"9"},{"issue":"9","key":"2419_CR18","doi-asserted-by":"publisher","first-page":"2701","DOI":"10.1021\/jm701181n","volume":"51","author":"P Grieco","year":"2008","unstructured":"Grieco P, Cai M, Liu L, Mayorov A, Chandler K, Trivedi D, Lin G, Campiglia P, Novellino E, Hruby VJ (2008) Design and microwave-assisted synthesis of novel macrocyclic peptides active at melanocortin receptors: discovery of potent and selective hMC5R receptor antagonists. J Med Chem 51(9):2701\u20132707. doi: 10.1021\/jm701181n","journal-title":"J Med Chem"},{"issue":"4","key":"2419_CR19","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1046\/j.0022-202x.2001.01286.x","volume":"116","author":"N Hatta","year":"2001","unstructured":"Hatta N, Dixon C, Ray AJ, Phillips SR, Cunliffe WJ, Dale M, Todd C, Meggit S, Birch-MacHin MA, Rees JL (2001) Expression, candidate gene, and population studies of the melanocortin 5 receptor. J Investig Dermatol 116(4):564\u2013570. doi: 10.1046\/j.0022-202x.2001.01286.x","journal-title":"J Investig Dermatol"},{"issue":"1","key":"2419_CR20","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1111\/j.1476-5381.2012.01968.x","volume":"167","author":"MK Kaneva","year":"2012","unstructured":"Kaneva MK, Kerrigan MJ, Grieco P, Curley GP, Locke IC, Getting SJ (2012) Chondroprotective and anti-inflammatory role of melanocortin peptides in TNF-alpha activated human C-20\/A4 chondrocytes. Br J Pharmacol 167(1):67\u201379. doi: 10.1111\/j.1476-5381.2012.01968.x","journal-title":"Br J Pharmacol"},{"issue":"2","key":"2419_CR21","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.bcp.2014.08.019","volume":"92","author":"MK Kaneva","year":"2014","unstructured":"Kaneva MK, Kerrigan MJ, Grieco P, Curley GP, Locke IC, Getting SJ (2014) Melanocortin peptides protect chondrocytes from mechanically induced cartilage injury. Biochem Pharmacol 92(2):336\u2013347. doi: 10.1016\/j.bcp.2014.08.019","journal-title":"Biochem Pharmacol"},{"issue":"10","key":"2419_CR22","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1002\/acr.21773","volume":"64","author":"D Khanna","year":"2012","unstructured":"Khanna D, Khanna PP, Fitzgerald JD, Singh MK, Bae S, Neogi T, Pillinger MH, Merill J, Lee S, Prakash S, Kaldas M, Gogia M, Perez-Ruiz F, Taylor W, Liote F, Choi H, Singh JA, Dalbeth N, Kaplan S, Niyyar V, Jones D, Yarows SA, Roessler B, Kerr G, King C, Levy G, Furst DE, Edwards NL, Mandell B, Schumacher HR, Robbins M, Wenger N, Terkeltaub R, American College of R (2012) 2012 American College of Rheumatology guidelines for management of gout. Part 2: therapy and antiinflammatory prophylaxis of acute gouty arthritis. Arthritis Care Res 64(10):1447\u20131461. doi: 10.1002\/acr.21773","journal-title":"Arthritis Care Res"},{"issue":"5587","key":"2419_CR23","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1126\/science.1073176","volume":"297","author":"DM Lee","year":"2002","unstructured":"Lee DM, Friend DS, Gurish MF, Benoist C, Mathis D, Brenner MB (2002) Mast cells: a cellular link between autoantibodies and inflammatory arthritis. Science 297(5587):1689\u20131692. doi: 10.1126\/science.1073176","journal-title":"Science"},{"key":"2419_CR24","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-014-0029-5","author":"LC Loram","year":"2014","unstructured":"Loram LC, Culp ME, Connolly-Strong EC, Sturgill-Koszycki S (2014) Melanocortin peptides: potential targets in systemic lupus erythematosus. Inflammation. doi: 10.1007\/s10753-014-0029-5","journal-title":"Inflammation"},{"issue":"4","key":"2419_CR25","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1021\/jm201139r","volume":"55","author":"BJ Melancon","year":"2012","unstructured":"Melancon BJ, Hopkins CR, Wood MR, Emmitte KA, Niswender CM, Christopoulos A, Conn PJ, Lindsley CW (2012) Allosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discovery. J Med Chem 55(4):1445\u20131464. doi: 10.1021\/jm201139r","journal-title":"J Med Chem"},{"issue":"3","key":"2419_CR26","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.smim.2015.02.003","volume":"27","author":"T Montero-Melendez","year":"2015","unstructured":"Montero-Melendez T (2015) ACTH: the forgotten therapy. Semin Immunol 27(3):216\u2013226. doi: 10.1016\/j.smim.2015.02.003","journal-title":"Semin Immunol"},{"issue":"4","key":"2419_CR27","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1038\/cdd.2012.154","volume":"20","author":"T Montero-Melendez","year":"2013","unstructured":"Montero-Melendez T, Dalli J, Perretti M (2013) Gene expression signature-based approach identifies a pro-resolving mechanism of action for histone deacetylase inhibitors. Cell Death Differ 20(4):567\u2013575. doi: 10.1038\/cdd.2012.154","journal-title":"Cell Death Differ"},{"issue":"7","key":"2419_CR28","doi-asserted-by":"publisher","first-page":"3381","DOI":"10.4049\/jimmunol.1402645","volume":"194","author":"T Montero-Melendez","year":"2015","unstructured":"Montero-Melendez T, Gobbetti T, Cooray SN, Jonassen TE, Perretti M (2015) Biased agonism as a novel strategy to harness the proresolving properties of melanocortin receptors without eliciting melanogenic effects. J Immunol 194(7):3381\u20133388. doi: 10.4049\/jimmunol.1402645","journal-title":"J Immunol"},{"issue":"8","key":"2419_CR29","doi-asserted-by":"publisher","first-page":"2333","DOI":"10.1016\/j.ajpath.2014.04.009","volume":"184","author":"T Montero-Melendez","year":"2014","unstructured":"Montero-Melendez T, Madeira MF, Norling LV, Alsam A, Curtis MA, da Silva TA, Perretti M (2014) Association between periodontal disease and inflammatory arthritis reveals modulatory functions by melanocortin receptor type 3. Am J Pathol 184(8):2333\u20132341. doi: 10.1016\/j.ajpath.2014.04.009","journal-title":"Am J Pathol"},{"issue":"1","key":"2419_CR30","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.ajpath.2011.03.042","volume":"179","author":"T Montero-Melendez","year":"2011","unstructured":"Montero-Melendez T, Patel HB, Seed M, Nielsen S, Jonassen TE, Perretti M (2011) The melanocortin agonist AP214 exerts anti-inflammatory and proresolving properties. Am J Pathol 179(1):259\u2013269. doi: 10.1016\/j.ajpath.2011.03.042","journal-title":"Am J Pathol"},{"issue":"7607","key":"2419_CR31","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1038\/534314a","volume":"534","author":"N Nosengo","year":"2016","unstructured":"Nosengo N (2016) Can you teach old drugs new tricks? Nature 534(7607):314\u2013316. doi: 10.1038\/534314a","journal-title":"Nature"},{"issue":"1\u20133","key":"2419_CR32","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.ejphar.2010.03.052","volume":"637","author":"A Ottani","year":"2010","unstructured":"Ottani A, Giuliani D, Galantucci M, Spaccapelo L, Novellino E, Grieco P, Jochem J, Guarini S (2010) Melanocortins counteract inflammatory and apoptotic responses to prolonged myocardial ischemia\/reperfusion through a vagus nerve-mediated mechanism. Eur J Pharmacol 637(1\u20133):124\u2013130. doi: 10.1016\/j.ejphar.2010.03.052","journal-title":"Eur J Pharmacol"},{"issue":"1","key":"2419_CR33","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.ejphar.2011.01.031","volume":"660","author":"J Pantel","year":"2011","unstructured":"Pantel J, Williams SY, Mi D, Sebag J, Corbin JD, Weaver CD, Cone RD (2011) Development of a high throughput screen for allosteric modulators of melanocortin-4 receptor signaling using a real time cAMP assay. Eur J Pharmacol 660(1):139\u2013147. doi: 10.1016\/j.ejphar.2011.01.031","journal-title":"Eur J Pharmacol"},{"issue":"12","key":"2419_CR34","doi-asserted-by":"publisher","first-page":"4835","DOI":"10.1096\/fj.10-167759","volume":"24","author":"HB Patel","year":"2010","unstructured":"Patel HB, Bombardieri M, Sampaio AL, D\u2019Acquisto F, Gray M, Grieco P, Getting SJ, Pitzalis C, Perretti M (2010) Anti-inflammatory and antiosteoclastogenesis properties of endogenous melanocortin receptor type 3 in experimental arthritis. FASEB J: Off Publ Fed Am Soc Exp Biol 24(12):4835\u20134843. doi: 10.1096\/fj.10-167759","journal-title":"FASEB J: Off Publ Fed Am Soc Exp Biol"},{"issue":"11","key":"2419_CR35","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1016\/j.tips.2015.07.007","volume":"36","author":"M Perretti","year":"2015","unstructured":"Perretti M, Leroy X, Bland EJ, Montero-Melendez T (2015) Resolution pharmacology: opportunities for therapeutic innovation in inflammation. Trends Pharmacol Sci 36(11):737\u2013755. doi: 10.1016\/j.tips.2015.07.007","journal-title":"Trends Pharmacol Sci"},{"issue":"4","key":"2419_CR36","first-page":"696","volume":"21","author":"J Ritter","year":"1994","unstructured":"Ritter J, Kerr LD, Valeriano-Marcet J, Spiera H (1994) ACTH revisited: effective treatment for acute crystal induced synovitis in patients with multiple medical problems. J Rheumatol 21(4):696\u2013699","journal-title":"J Rheumatol"},{"key":"2419_CR37","doi-asserted-by":"publisher","first-page":"21","DOI":"10.3389\/fneur.2013.00021","volume":"4","author":"AP Ross","year":"2013","unstructured":"Ross AP, Ben-Zacharia A, Harris C, Smrtka J (2013) Multiple sclerosis, relapses, and the mechanism of action of adrenocorticotropic hormone. Front Neurol 4:21. doi: 10.3389\/fneur.2013.00021","journal-title":"Front Neurol"},{"issue":"3","key":"2419_CR38","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1038\/nrd3681","volume":"11","author":"JW Scannell","year":"2012","unstructured":"Scannell JW, Blanckley A, Boldon H, Warrington B (2012) Diagnosing the decline in pharmaceutical R&D efficiency. Nat Rev Drug Discov 11(3):191\u2013200. doi: 10.1038\/nrd3681","journal-title":"Nat Rev Drug Discov"},{"issue":"5","key":"2419_CR39","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1096\/fj.11-0502ufm","volume":"25","author":"CN Serhan","year":"2011","unstructured":"Serhan CN (2011) The resolution of inflammation: the devil in the flask and in the details. FASEB J Off Publ Fed Am Soc Exp Biol 25(5):1441\u20131448. doi: 10.1096\/fj.11-0502ufm","journal-title":"FASEB J Off Publ Fed Am Soc Exp Biol"},{"issue":"2\u20133","key":"2419_CR40","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/j.ejphar.2011.09.015","volume":"670","author":"L Spaccapelo","year":"2011","unstructured":"Spaccapelo L, Bitto A, Galantucci M, Ottani A, Irrera N, Minutoli L, Altavilla D, Novellino E, Grieco P, Zaffe D, Squadrito F, Giuliani D, Guarini S (2011) Melanocortin MC(4) receptor agonists counteract late inflammatory and apoptotic responses and improve neuronal functionality after cerebral ischemia. Eur J Pharmacol 670(2\u20133):479\u2013486. doi: 10.1016\/j.ejphar.2011.09.015","journal-title":"Eur J Pharmacol"},{"issue":"17","key":"2419_CR41","doi-asserted-by":"crossref","first-page":"8016","DOI":"10.1073\/pnas.92.17.8016","volume":"92","author":"RA Star","year":"1995","unstructured":"Star RA, Rajora N, Huang J, Stock RC, Catania A, Lipton JM (1995) Evidence of autocrine modulation of macrophage nitric oxide synthase by alpha-melanocyte-stimulating hormone. Proc Natl Acad Sci USA 92(17):8016\u20138020","journal-title":"Proc Natl Acad Sci USA"},{"issue":"8","key":"2419_CR42","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1038\/nrd4052","volume":"12","author":"D Wootten","year":"2013","unstructured":"Wootten D, Christopoulos A, Sexton PM (2013) Emerging paradigms in GPCR allostery: implications for drug discovery. Nat Rev Drug Discov 12(8):630\u2013644. doi: 10.1038\/nrd4052","journal-title":"Nat Rev Drug Discov"},{"issue":"19","key":"2419_CR43","doi-asserted-by":"publisher","first-page":"8782","DOI":"10.1073\/pnas.0912176107","volume":"107","author":"M Zaidi","year":"2010","unstructured":"Zaidi M, Sun L, Robinson LJ, Tourkova IL, Liu L, Wang Y, Zhu LL, Liu X, Li J, Peng Y, Yang G, Shi X, Levine A, Iqbal J, Yaroslavskiy BB, Isales C, Blair HC (2010) ACTH protects against glucocorticoid-induced osteonecrosis of bone. Proc Natl Acad Sci USA 107(19):8782\u20138787. doi: 10.1073\/pnas.0912176107","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Cellular and Molecular Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-016-2419-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00018-016-2419-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-016-2419-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T23:23:45Z","timestamp":1692573825000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00018-016-2419-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,16]]},"references-count":43,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["2419"],"URL":"https:\/\/doi.org\/10.1007\/s00018-016-2419-3","relation":{},"ISSN":["1420-682X","1420-9071"],"issn-type":[{"value":"1420-682X","type":"print"},{"value":"1420-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,16]]}}}