{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T19:40:30Z","timestamp":1787946030927,"version":"build-2784847793"},"reference-count":116,"publisher":"Springer Science and Business Media LLC","issue":"16","license":[{"start":{"date-parts":[[2017,4,7]],"date-time":"2017-04-07T00:00:00Z","timestamp":1491523200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell. Mol. Life Sci."],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1007\/s00018-017-2519-8","type":"journal-article","created":{"date-parts":[[2017,4,7]],"date-time":"2017-04-07T06:54:06Z","timestamp":1491548046000},"page":"3023-3037","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Superoxide dismutase 1 is positively selected to minimize protein aggregation in great apes"],"prefix":"10.1007","volume":"74","author":[{"given":"Pouria","family":"Dasmeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasper P.","family":"Kepp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,4,7]]},"reference":[{"key":"2519_CR1","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1038\/nrg2718","volume":"11","author":"DC Presgraves","year":"2010","unstructured":"Presgraves DC (2010) The molecular evolutionary basis of species formation. Nat Rev Genet 11:175\u2013180. doi: 10.1038\/nrg2718","journal-title":"Nat Rev Genet"},{"key":"2519_CR2","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/nrg2506","volume":"10","author":"LD Hurst","year":"2009","unstructured":"Hurst LD (2009) Fundamental concepts in genetics: genetics and the understanding of selection. Nat Rev Genet 10:83\u201393. doi: 10.1038\/nrg2506","journal-title":"Nat Rev Genet"},{"key":"2519_CR3","unstructured":"Gillespie JH (1991) The Causes of Molecular Evolution. Oxford Ser Ecol Evol. doi:0195092716"},{"key":"2519_CR4","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1126\/science.1090005","volume":"188","author":"MC King","year":"1975","unstructured":"King MC, Wilson AC (1975) Evolution at two levels in humans and chimpanzees. Science 188:107\u2013116","journal-title":"Science"},{"key":"2519_CR5","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/nrg3707","volume":"15","author":"J Rogers","year":"2014","unstructured":"Rogers J, Gibbs RA (2014) Comparative primate genomics: emerging patterns of genome content and dynamics. Nat Rev Genet 15:347\u2013359","journal-title":"Nat Rev Genet"},{"issue":"Suppl","key":"2519_CR6","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/ng1088","volume":"33","author":"KH Wolfe","year":"2003","unstructured":"Wolfe KH, Li W-H (2003) Molecular evolution meets the genomics revolution. Nat Genet 33(Suppl):255\u2013265. doi: 10.1038\/ng1088","journal-title":"Nat Genet"},{"key":"2519_CR7","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1146\/annurev.genom.5.061903.180040","volume":"5","author":"W Enard","year":"2004","unstructured":"Enard W, P\u00e4\u00e4bo S (2004) Comparative primate genomics. Annu Rev Genomics Hum Genet 5:351\u2013378","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"2519_CR8","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.tig.2005.06.012","volume":"21","author":"M Goodman","year":"2005","unstructured":"Goodman M, Grossman LI, Wildman DE (2005) Moving primate genomics beyond the chimpanzee genome. Trends Genet 21:511\u2013517","journal-title":"Trends Genet"},{"key":"2519_CR9","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.neuron.2008.04.017","volume":"58","author":"M Corbetta","year":"2008","unstructured":"Corbetta M, Patel G, Shulman GL (2008) The reorienting system of the human brain: from environment to theory of mind. Neuron 58:306\u2013324","journal-title":"Neuron"},{"key":"2519_CR10","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1002\/ajpa.10021","volume":"116","author":"CJ Jolly","year":"2001","unstructured":"Jolly CJ (2001) A proper study for mankind: analogies from the Papionin monkeys and their implications for human evolution. Am J Phys Anthropol 116:177\u2013204. doi: 10.1002\/ajpa.10021","journal-title":"Am J Phys Anthropol"},{"key":"2519_CR11","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/nature09687","volume":"469","author":"DP Locke","year":"2011","unstructured":"Locke DP, Hillier LW, Warren WC et al (2011) Comparative and demographic analysis of orang-utan genomes. Nature 469:529\u2013533","journal-title":"Nature"},{"key":"2519_CR12","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1126\/science.1081331","volume":"299","author":"D Boffelli","year":"2003","unstructured":"Boffelli D, McAuliffe J, Ovcharenko D et al (2003) Phylogenetic shadowing of primate sequences to find functional regions of the human genome. Science 299:1391\u20131394. doi: 10.1126\/science.1081331","journal-title":"Science"},{"key":"2519_CR13","doi-asserted-by":"crossref","first-page":"e1000271","DOI":"10.1371\/journal.pgen.1000271","volume":"4","author":"R Blekhman","year":"2008","unstructured":"Blekhman R, Oshlack A, Chabot AE et al (2008) Gene regulation in primates evolves under tissue-specific selection pressures. PLoS Genet 4:e1000271","journal-title":"PLoS Genet"},{"key":"2519_CR14","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1101\/gr.130468.111","volume":"22","author":"GH Perry","year":"2012","unstructured":"Perry GH, Melsted P, Marioni JC et al (2012) Comparative RNA sequencing reveals substantial genetic variation in endangered primates. Genome Res 22:602\u2013610. doi: 10.1101\/gr.130468.111","journal-title":"Genome Res"},{"key":"2519_CR15","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1038\/nrg2187","volume":"8","author":"R Nielsen","year":"2007","unstructured":"Nielsen R, Hellmann I, Hubisz M et al (2007) Recent and ongoing selection in the human genome. Nat Rev Genet 8:857\u2013868. doi: 10.1038\/nrg2187","journal-title":"Nat Rev Genet"},{"key":"2519_CR16","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1126\/science.1124309","volume":"312","author":"PC Sabeti","year":"2006","unstructured":"Sabeti PC, Schaffner SF, Fry B et al (2006) Positive natural selection in the human lineage. Science 312:1614\u20131620. doi: 10.1126\/science.1124309","journal-title":"Science"},{"key":"2519_CR17","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1038\/nrg3336","volume":"13","author":"M O\u2019Bleness","year":"2012","unstructured":"O\u2019Bleness M, Searles VB, Varki A et al (2012) Evolution of genetic and genomic features unique to the human lineage. Nat Rev Genet 13:853\u2013866. doi: 10.1038\/nrg3336","journal-title":"Nat Rev Genet"},{"key":"2519_CR18","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1073\/pnas.92.4.954","volume":"92","author":"CA Pardo","year":"1995","unstructured":"Pardo CA, Xu Z, Borchelt DR et al (1995) Superoxide dismutase is an abundant component in cell bodies, dendrites, and axons of motor neurons and in a subset of other neurons. Proc Natl Acad Sci USA 92:954\u2013958","journal-title":"Proc Natl Acad Sci USA"},{"key":"2519_CR19","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.bbapap.2009.11.004","volume":"1804","author":"J Perry","year":"2010","unstructured":"Perry J, Shin D, Getzoff E, Tainer J (2010) The structural biochemistry of the superoxide dismutases. Biochim Biophys Acta 1804:245\u2013262. doi: 10.1016\/j.bbapap.2009.11.004","journal-title":"Biochim Biophys Acta"},{"key":"2519_CR20","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.cell.2012.11.046","volume":"152","author":"AR Reddi","year":"2013","unstructured":"Reddi AR, Culotta VC (2013) SOD1 integrates signals from oxygen and glucose to repress respiration. Cell 152:224\u2013235. doi: 10.1016\/j.cell.2012.11.046","journal-title":"Cell"},{"key":"2519_CR21","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/prot.340050408","volume":"5","author":"ED Getzoff","year":"1989","unstructured":"Getzoff ED, Tainer JA, Stempien MM et al (1989) Evolution of CuZn superoxide dismutase and the Greek key \u03b2-barrel structural motif. Proteins Struct Funct Bioinforma 5:322\u2013336","journal-title":"Proteins Struct Funct Bioinforma"},{"key":"2519_CR22","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.mad.2004.08.012","volume":"126","author":"GN Landis","year":"2005","unstructured":"Landis GN, Tower J (2005) Superoxide dismutase evolution and life span regulation. Mech Ageing Dev 126:365\u2013379. doi: 10.1016\/j.mad.2004.08.012","journal-title":"Mech Ageing Dev"},{"key":"2519_CR23","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1128\/MCB.19.1.216","volume":"19","author":"J Sun","year":"1999","unstructured":"Sun J, Tower J (1999) FLP recombinase-mediated induction of Cu\/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies. Mol Cell Biol 19:216\u2013228","journal-title":"Mol Cell Biol"},{"key":"2519_CR24","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1126\/science.289.5484.1567","volume":"289","author":"S Melov","year":"2000","unstructured":"Melov S, Ravenscroft J, Malik S et al (2000) Extension of life-span with superoxide dismutase\/catalase mimetics. Science 289:1567\u20131569. doi: 10.1126\/science.289.5484.1567","journal-title":"Science"},{"key":"2519_CR25","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1111\/j.1471-4159.2006.04408.x","volume":"101","author":"J-L Gonzalez de Aguilar","year":"2007","unstructured":"Gonzalez de Aguilar J-L, Echaniz-Laguna A, Fergani A et al (2007) Amyotrophic lateral sclerosis: all roads lead to Rome. J Neurochem 101:1153\u20131160. doi: 10.1111\/j.1471-4159.2006.04408.x","journal-title":"J Neurochem"},{"key":"2519_CR26","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/362059a0","volume":"362","author":"DR Rosen","year":"1993","unstructured":"Rosen DR, Siddique T, Patterson D et al (1993) Mutations in Cu\/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 362:59\u201362. doi: 10.1038\/362059a0","journal-title":"Nature"},{"key":"2519_CR27","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/nn.3584","volume":"17","author":"AE Renton","year":"2014","unstructured":"Renton AE, Chi\u00f2 A, Traynor BJ (2014) State of play in amyotrophic lateral sclerosis genetics. Nat Neurosci 17:17\u201323. doi: 10.1038\/nn.3584","journal-title":"Nat Neurosci"},{"key":"2519_CR28","doi-asserted-by":"crossref","first-page":"10218","DOI":"10.1073\/pnas.0601696103","volume":"103","author":"A Nordlund","year":"2006","unstructured":"Nordlund A, Oliveberg M (2006) Folding of Cu\/Zn superoxide dismutase suggests structural hotspots for gain of neurotoxic function in ALS: parallels to precursors in amyloid disease. Proc Natl Acad Sci 103:10218\u201310223","journal-title":"Proc Natl Acad Sci"},{"key":"2519_CR29","doi-asserted-by":"publisher","first-page":"19544","DOI":"10.1074\/jbc.M109.086074","volume":"285","author":"R Bystr\u00f6m","year":"2010","unstructured":"Bystr\u00f6m R, Andersen PM, Gr\u00f6bner G, Oliveberg M (2010) SOD1 mutations targeting surface hydrogen bonds promote amyotrophic lateral sclerosis without reducing apo-state stability. J Biol Chem 285:19544\u201319552. doi: 10.1074\/jbc.M109.086074","journal-title":"J Biol Chem"},{"key":"2519_CR30","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.bbadis.2009.08.012","volume":"1802","author":"P Shi","year":"2010","unstructured":"Shi P, Gal J, Kwinter DM et al (2010) Mitochondrial dysfunction in amyotrophic lateral sclerosis. Biochim Biophys Acta 1802:45\u201351. doi: 10.1016\/j.bbadis.2009.08.012","journal-title":"Biochim Biophys Acta"},{"key":"2519_CR31","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/35030140","volume":"407","author":"P Huang","year":"2000","unstructured":"Huang P, Feng L, Oldham EA et al (2000) Superoxide dismutase as a target for the selective killing of cancer cells. Nature 407:390\u2013395","journal-title":"Nature"},{"key":"2519_CR32","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1038\/nature02661","volume":"429","author":"T Lu","year":"2004","unstructured":"Lu T, Pan Y, Kao S-Y et al (2004) Gene regulation and DNA damage in the ageing human brain. Nature 429:883\u2013891. doi: 10.1038\/nature02661","journal-title":"Nature"},{"key":"2519_CR33","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/ng0596-25","volume":"13","author":"GM Martin","year":"1996","unstructured":"Martin GM, Austad SN, Johnson TE (1996) Genetic analysis of ageing: role of oxidative damage and environmental stresses. Nat Genet 13:25\u201334","journal-title":"Nat Genet"},{"key":"2519_CR34","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1007\/s10863-011-9394-z","volume":"43","author":"M Carr\u00ec","year":"2011","unstructured":"Carr\u00ec M, Cozzolino M (2011) SOD1 and mitochondria in ALS: a dangerous liaison. J Bioenerg Biomembr 43:593\u2013599. doi: 10.1007\/s10863-011-9394-z","journal-title":"J Bioenerg Biomembr"},{"key":"2519_CR35","doi-asserted-by":"publisher","first-page":"e0118649","DOI":"10.1371\/journal.pone.0118649","volume":"10","author":"KP Kepp","year":"2015","unstructured":"Kepp KP (2015) Genotype-property patient-phenotype relations suggest that proteome exhaustion can cause amyotrophic lateral sclerosis. PLoS One 10:e0118649. doi: 10.1371\/journal.pone.0118649","journal-title":"PLoS One"},{"key":"2519_CR36","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1073\/pnas.82.3.824","volume":"82","author":"YM Lee","year":"1985","unstructured":"Lee YM, Friedman DJ, Ayala FJ (1985) Superoxide dismutase: an evolutionary puzzle. Proc Natl Acad Sci 82:824\u2013828","journal-title":"Proc Natl Acad Sci"},{"key":"2519_CR37","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0378-1119(02)00837-5","volume":"296","author":"R Fukuhara","year":"2002","unstructured":"Fukuhara R, Tezuka T, Kageyama T (2002) Structure, molecular evolution, and gene expression of primate superoxide dismutases. Gene 296:99\u2013109","journal-title":"Gene"},{"key":"2519_CR38","doi-asserted-by":"crossref","first-page":"e32","DOI":"10.1371\/journal.pgen.0040032","volume":"4","author":"AM Hancock","year":"2008","unstructured":"Hancock AM, Witonsky DB, Gordon AS et al (2008) Adaptations to climate in candidate genes for common metabolic disorders. PLoS Genet 4:e32","journal-title":"PLoS Genet"},{"key":"2519_CR39","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1126\/science.1211028","volume":"334","author":"RW Meredith","year":"2011","unstructured":"Meredith RW, Jane\u010dka JE, Gatesy J et al (2011) Impacts of the cretaceous terrestrial revolution and kpg extinction on mammal diversification. Science 334:521\u2013524","journal-title":"Science"},{"key":"2519_CR40","first-page":"127","volume-title":"Adv. Protein Chem. Struct. Biol","author":"BF Shaw","year":"2010","unstructured":"Shaw BF, Moustakas DT, Whitelegge JP, Faull KF (2010) Taking charge of proteins: from neurodegeneration to industrial biotechnology. In: Biology AMBT-A in PC and S (ed) Adv. Protein Chem. Struct. Biol. Academic Press, New York, pp 127\u2013164"},{"key":"2519_CR41","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1016\/j.jmb.2005.11.081","volume":"356","author":"RW Strange","year":"2006","unstructured":"Strange RW, Antonyuk SV, Hough MA et al (2006) Variable metallation of human superoxide dismutase: atomic resolution crystal structures of Cu\u2013Zn, Zn\u2013Zn and as-isolated wild-type enzymes. J Mol Biol 356:1152\u20131162. doi: 10.1016\/j.jmb.2005.11.081","journal-title":"J Mol Biol"},{"key":"2519_CR42","doi-asserted-by":"publisher","first-page":"D190","DOI":"10.1093\/nar\/gkm895","volume":"36","author":"Consortium TU","year":"2008","unstructured":"Consortium TU (2008) The Universal Protein Resource (UniProt). Nucleic Acids Res 36:D190\u2013D195. doi: 10.1093\/nar\/gkm895","journal-title":"Nucleic Acids Res"},{"key":"2519_CR43","doi-asserted-by":"crossref","first-page":"e1002929","DOI":"10.1371\/journal.pcbi.1002929","volume":"9","author":"P Dasmeh","year":"2013","unstructured":"Dasmeh P, Serohijos AWR, Kepp KP, Shakhnovich EI (2013) Positively selected sites in cetacean myoglobins contribute to protein stability. PLoS Comput Biol 9:e1002929","journal-title":"PLoS Comput Biol"},{"key":"2519_CR44","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1016\/j.bbapap.2016.04.004","volume":"1864","author":"J Holm","year":"2016","unstructured":"Holm J, Dasmeh P, Kepp KP (2016) Tracking evolution of myoglobin stability in cetaceans using experimentally calibrated computational methods that account for generic protein relaxation. Biochim Biophys Acta Proteins Proteom 1864:825\u2013834. doi: 10.1016\/j.bbapap.2016.04.004","journal-title":"Biochim Biophys Acta Proteins Proteom"},{"key":"2519_CR45","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/msb.2011.75","volume":"7","author":"F Sievers","year":"2011","unstructured":"Sievers F, Wilm A, Dineen D et al (2011) Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega. Mol Syst Biol 7:539","journal-title":"Mol Syst Biol"},{"key":"2519_CR46","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1214\/aos\/1176344136","volume":"6","author":"G Schwarz","year":"1978","unstructured":"Schwarz G (1978) Estimating the dimension of a model. Ann Stat 6:461\u2013464","journal-title":"Ann Stat"},{"key":"2519_CR47","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.molbev.a003851","author":"S Whelan","year":"2001","unstructured":"Whelan S, Goldman N (2001) A general empirical model of protein evolution derived from multiple protein families using a maximum-likelihood approach. Mol Biol Evol. doi: 10.1093\/oxfordjournals.molbev.a003851","journal-title":"Mol Biol Evol"},{"key":"2519_CR48","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0169-5347(96)10041-0","volume":"11","author":"Z Yang","year":"1996","unstructured":"Yang Z (1996) Among-site rate variation and its impact on phylogenetic analyses. Trends Ecol Evol 11:367\u2013372","journal-title":"Trends Ecol Evol"},{"key":"2519_CR49","doi-asserted-by":"publisher","first-page":"e69","DOI":"10.1371\/journal.pcbi.0020069","volume":"2","author":"PD Williams","year":"2006","unstructured":"Williams PD, Pollock DD, Blackburne BP, Goldstein RA (2006) Assessing the accuracy of ancestral protein reconstruction methods. PLoS Comput Biol 2:e69. doi: 10.1371\/journal.pcbi.0020069","journal-title":"PLoS Comput Biol"},{"key":"2519_CR50","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1093\/oxfordjournals.molbev.a004148","volume":"19","author":"Z Yang","year":"2002","unstructured":"Yang Z, Nielsen R (2002) Codon-substitution models for detecting molecular adaptation at individual sites along specific lineages. Mol Biol Evol 19:908\u2013917","journal-title":"Mol Biol Evol"},{"key":"2519_CR51","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1098\/rsta.1933.0009","volume":"231","author":"J Neyman","year":"1933","unstructured":"Neyman J, Pearson ES (1933) On the problem of the most efficient tests of statistical hypotheses. Philos Trans R Soc Lond A 231:289\u2013337","journal-title":"Philos Trans R Soc Lond A"},{"key":"2519_CR52","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1093\/genetics\/155.1.431","volume":"155","author":"ZH Yang","year":"2000","unstructured":"Yang ZH, Nielsen R, Goldman N, Pedersen AMK (2000) Codon-substitution models for heterogeneous selection pressure at amino acid sites. Genetics 155:431\u2013449","journal-title":"Genetics"},{"key":"2519_CR53","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.1093\/molbev\/msm088","volume":"24","author":"Z Yang","year":"2007","unstructured":"Yang Z (2007) PAML 4: phylogenetic analysis by maximum likelihood. Mol Biol Evol 24:1586\u20131591. doi: 10.1093\/molbev\/msm088","journal-title":"Mol Biol Evol"},{"key":"2519_CR54","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1093\/bioinformatics\/bti320","volume":"21","author":"SLK Pond","year":"2005","unstructured":"Pond SLK, Frost SDW (2005) Datamonkey: rapid detection of selective pressure on individual sites of codon alignments. Bioinformatics 21:2531\u20132533","journal-title":"Bioinformatics"},{"key":"2519_CR55","doi-asserted-by":"crossref","first-page":"e1002764","DOI":"10.1371\/journal.pgen.1002764","volume":"8","author":"B Murrell","year":"2012","unstructured":"Murrell B, Wertheim JO, Moola S et al (2012) Detecting individual sites subject to episodic diversifying selection. PLoS Genet 8:e1002764","journal-title":"PLoS Genet"},{"key":"2519_CR56","doi-asserted-by":"crossref","unstructured":"Murrell B, Moola S, Mabona A et al (2013) FUBAR: a fast, unconstrained bayesian approximation for inferring selection. Mol Biol Evol:mst030","DOI":"10.1093\/molbev\/mst030"},{"key":"2519_CR57","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/molbev\/msu400","volume":"32","author":"JO Wertheim","year":"2014","unstructured":"Wertheim JO, Murrell B, Smith MD et al (2014) RELAX: detecting relaxed selection in a phylogenetic framework. Mol Biol Evol 32:1\u201313. doi: 10.1093\/molbev\/msu400","journal-title":"Mol Biol Evol"},{"key":"2519_CR58","doi-asserted-by":"publisher","first-page":"2210","DOI":"10.1073\/pnas.0913021108","volume":"108","author":"KA Vassall","year":"2011","unstructured":"Vassall KA, Stubbs HR, Primmer HA et al (2011) Decreased stability and increased formation of soluble aggregates by immature superoxide dismutase do not account for disease severity in ALS. Proc Natl Acad Sci USA 108:2210\u20132215. doi: 10.1073\/pnas.0913021108","journal-title":"Proc Natl Acad Sci USA"},{"key":"2519_CR59","doi-asserted-by":"publisher","first-page":"17266","DOI":"10.1074\/jbc.M500482200","volume":"280","author":"Y Furukawa","year":"2005","unstructured":"Furukawa Y, O\u2019Halloran TV (2005) Amyotrophic lateral sclerosis mutations have the greatest destabilizing effect on the apo- and reduced form of SOD1, leading to unfolding and oxidative aggregation. J Biol Chem 280:17266\u201317274. doi: 10.1074\/jbc.M500482200","journal-title":"J Biol Chem"},{"key":"2519_CR60","doi-asserted-by":"publisher","first-page":"9754","DOI":"10.1073\/pnas.0501957102","volume":"102","author":"MJ Lindberg","year":"2005","unstructured":"Lindberg MJ, Bystr\u00f6m R, Bokn\u00e4s N et al (2005) Systematically perturbed folding patterns of amyotrophic lateral sclerosis (ALS)-associated SOD1 mutants. Proc Natl Acad Sci USA 102:9754\u20139759. doi: 10.1073\/pnas.0501957102","journal-title":"Proc Natl Acad Sci USA"},{"key":"2519_CR61","doi-asserted-by":"publisher","first-page":"e170","DOI":"10.1371\/journal.pbio.0060170","volume":"6","author":"Q Wang","year":"2008","unstructured":"Wang Q, Johnson JL, Agar NYR, Agar JN (2008) Protein aggregation and protein instability govern familial amyotrophic lateral sclerosis patient survival. PLoS Biol 6:e170. doi: 10.1371\/journal.pbio.0060170","journal-title":"PLoS Biol"},{"key":"2519_CR62","doi-asserted-by":"crossref","first-page":"W306","DOI":"10.1093\/nar\/gki375","volume":"33","author":"E Capriotti","year":"2005","unstructured":"Capriotti E, Fariselli P, Casadio R (2005) I-Mutant2.0: predicting stability changes upon mutation from the protein sequence or structure. Nucleic Acids Res 33:W306\u2013W310","journal-title":"Nucleic Acids Res"},{"key":"2519_CR63","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1186\/1471-2105-12-151","volume":"12","author":"Y Dehouck","year":"2011","unstructured":"Dehouck Y, Kwasigroch JM, Gilis D, Rooman M (2011) PoPMuSiC 2.1: a web server for the estimation of protein stability changes upon mutation and sequence optimality. BMC Bioinform 12:151. doi: 10.1186\/1471-2105-12-151","journal-title":"BMC Bioinform"},{"key":"2519_CR64","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1021\/jp4119138","volume":"118","author":"KP Kepp","year":"2014","unstructured":"Kepp KP (2014) Computing stability effects of mutations in human superoxide dismutase 1. J Phys Chem B 118:1799\u20131812","journal-title":"J Phys Chem B"},{"key":"2519_CR65","doi-asserted-by":"publisher","first-page":"3028","DOI":"10.1021\/ci300398z","volume":"52","author":"NJ Christensen","year":"2012","unstructured":"Christensen NJ, Kepp KP (2012) Accurate stabilities of laccase mutants predicted with a modified FoldX protocol. J Chem Inf Model 52:3028\u20133042. doi: 10.1021\/ci300398z","journal-title":"J Chem Inf Model"},{"key":"2519_CR66","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1016\/j.bbapap.2015.06.002","volume":"1854","author":"KP Kepp","year":"2015","unstructured":"Kepp KP (2015) Towards a \u201cGolden Standard\u201d for computing globin stability: stability and structure sensitivity of myoglobin mutants. Biochim Biophys Acta Proteins Proteom 1854:1239\u20131248. doi: 10.1016\/j.bbapap.2015.06.002","journal-title":"Biochim Biophys Acta Proteins Proteom"},{"issue":"suppl 1","key":"2519_CR67","doi-asserted-by":"publisher","first-page":"i63","DOI":"10.1093\/bioinformatics\/bth928","volume":"20","author":"E Capriotti","year":"2004","unstructured":"Capriotti E, Fariselli P, Casadio R (2004) A neural-network-based method for predicting protein stability changes upon single point mutations. Bioinformatics 20(suppl 1):i63\u2013i68. doi: 10.1093\/bioinformatics\/bth928","journal-title":"Bioinformatics"},{"key":"2519_CR68","doi-asserted-by":"publisher","first-page":"e46084","DOI":"10.1371\/journal.pone.0046084","volume":"7","author":"G Thiltgen","year":"2012","unstructured":"Thiltgen G, Goldstein RA (2012) Assessing predictors of changes in protein stability upon mutation using self-consistency. PLoS One 7:e46084. doi: 10.1371\/journal.pone.0046084","journal-title":"PLoS One"},{"key":"2519_CR69","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2007.03.069","author":"N Tokuriki","year":"2007","unstructured":"Tokuriki N, Stricher F, Schymkowitz J et al (2007) The stability effects of protein mutations appear to be universally distributed. J Mol Biol. doi: 10.1016\/j.jmb.2007.03.069","journal-title":"J Mol Biol"},{"key":"2519_CR70","doi-asserted-by":"publisher","first-page":"4388","DOI":"10.1016\/j.jmb.2013.07.018","volume":"425","author":"Y Shi","year":"2013","unstructured":"Shi Y, Mowery RA, Shaw BF (2013) Effect of metal loading and subcellular pH on net charge of superoxide dismutase-1. J Mol Biol 425:4388\u20134404. doi: 10.1016\/j.jmb.2013.07.018","journal-title":"J Mol Biol"},{"key":"2519_CR71","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1126\/science.272.5261.535","volume":"272","author":"J Gao","year":"1996","unstructured":"Gao J, Mammen M, Whitesides GM (1996) Evaluating electrostatic contributions to binding with the use of protein charge ladders. Science 272:535","journal-title":"Science"},{"key":"2519_CR72","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1002\/pro.2526","volume":"23","author":"Y Shi","year":"2014","unstructured":"Shi Y, Abdolvahabi A, Shaw BF (2014) Protein charge ladders reveal that the net charge of ALS-linked superoxide dismutase can be different in sign and magnitude from predicted values. Protein Sci 23:1417\u20131433","journal-title":"Protein Sci"},{"key":"2519_CR73","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.tibs.2006.12.005","volume":"32","author":"BF Shaw","year":"2007","unstructured":"Shaw BF, Valentine JS (2007) How do ALS-associated mutations in superoxide dismutase 1 promote aggregation of the protein? Trends Biochem Sci 32:78\u201385. doi: 10.1016\/j.tibs.2006.12.005","journal-title":"Trends Biochem Sci"},{"key":"2519_CR74","doi-asserted-by":"publisher","first-page":"12402","DOI":"10.1073\/pnas.1511308112","volume":"112","author":"J Danielsson","year":"2015","unstructured":"Danielsson J, Mu X, Lang L et al (2015) Thermodynamics of protein destabilization in live cells. Proc Natl Acad Sci USA 112:12402\u201312407. doi: 10.1073\/pnas.1511308112","journal-title":"Proc Natl Acad Sci USA"},{"key":"2519_CR75","doi-asserted-by":"publisher","first-page":"e1003125","DOI":"10.1371\/journal.pgen.1003125","volume":"8","author":"T Mailund","year":"2012","unstructured":"Mailund T, Halager AE, Westergaard M et al (2012) A new isolation with migration model along complete genomes infers very different divergence processes among closely related great ape species. PLoS Genet 8:e1003125. doi: 10.1371\/journal.pgen.1003125","journal-title":"PLoS Genet"},{"key":"2519_CR76","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1006\/mpev.1996.0012","volume":"5","author":"WH Li","year":"1996","unstructured":"Li WH, Ellsworth DL, Krushkal J et al (1996) Rates of nucleotide substitution in primates and rodents and the generation-time effect hypothesis. Mol Phylogenet Evol 5:182\u2013187. doi: 10.1006\/mpev.1996.0012","journal-title":"Mol Phylogenet Evol"},{"key":"2519_CR77","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1126\/science.3082006","volume":"231","author":"RJ Britten","year":"1986","unstructured":"Britten RJ (1986) Rates of DNA sequence evolution differ between taxonomic groups. Science 231:1393\u20131398","journal-title":"Science"},{"key":"2519_CR78","first-page":"193","volume":"9","author":"S Seino","year":"1992","unstructured":"Seino S, Bell GI, Li WH (1992) Sequences of primate insulin genes support the hypothesis of a slower rate of molecular evolution in humans and apes than in monkeys. Mol Biol Evol 9:193\u2013203","journal-title":"Mol Biol Evol"},{"key":"2519_CR79","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1093\/oxfordjournals.molbev.a004043","volume":"19","author":"S Yi","year":"2002","unstructured":"Yi S, Ellsworth DL, Li W-H (2002) Slow molecular clocks in Old World monkeys, apes, and humans. Mol Biol Evol 19:2191\u20132198","journal-title":"Mol Biol Evol"},{"key":"2519_CR80","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s002390010132","volume":"52","author":"DM Weinreich","year":"2001","unstructured":"Weinreich DM (2001) The rates of molecular evolution in rodent and primate mitochondrial DNA. J Mol Evol 52:40\u201350","journal-title":"J Mol Evol"},{"key":"2519_CR81","doi-asserted-by":"crossref","first-page":"4087","DOI":"10.1073\/pnas.90.9.4087","volume":"90","author":"AP Martin","year":"1993","unstructured":"Martin AP, Palumbi SR (1993) Body size, metabolic rate, generation time, and the molecular clock. Proc Natl Acad Sci USA 90:4087\u20134091","journal-title":"Proc Natl Acad Sci USA"},{"key":"2519_CR82","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1073\/pnas.77.5.2777","volume":"77","author":"JM Tolmasoff","year":"1980","unstructured":"Tolmasoff JM, Ono T, Cutler RG (1980) Superoxide dismutase: correlation with life-span and specific metabolic rate in primate species. Proc Natl Acad Sci 77:2777\u20132781","journal-title":"Proc Natl Acad Sci"},{"key":"2519_CR83","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1093\/molbev\/msm042","volume":"24","author":"M Anisimova","year":"2007","unstructured":"Anisimova M, Yang Z (2007) Multiple hypothesis testing to detect lineages under positive selection that affects only a few sites. Mol Biol Evol 24:1219\u20131228","journal-title":"Mol Biol Evol"},{"key":"2519_CR84","doi-asserted-by":"publisher","first-page":"19696","DOI":"10.1073\/pnas.0803266105","volume":"105","author":"F Ding","year":"2008","unstructured":"Ding F, Dokholyan NV (2008) Dynamical roles of metal ions and the disulfide bond in Cu, Zn superoxide dismutase folding and aggregation. Proc Natl Acad Sci USA 105:19696\u201319701. doi: 10.1073\/pnas.0803266105","journal-title":"Proc Natl Acad Sci USA"},{"key":"2519_CR85","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1002\/humu.21242","volume":"31","author":"S Khan","year":"2010","unstructured":"Khan S, Vihinen M (2010) Performance of protein stability predictors. Hum Mutat 31:675\u2013684. doi: 10.1002\/humu.21242","journal-title":"Hum Mutat"},{"key":"2519_CR86","doi-asserted-by":"publisher","first-page":"27129","DOI":"10.1074\/jbc.M000452200","volume":"275","author":"EE Scott","year":"2000","unstructured":"Scott EE, Paster EV, Olson JS (2000) The stabilities of mammalian apomyoglobins vary over a 600-fold range and can be enhanced by comparative mutagenesis. J Biol Chem 275:27129\u201327136. doi: 10.1074\/jbc.M000452200","journal-title":"J Biol Chem"},{"key":"2519_CR87","doi-asserted-by":"publisher","first-page":"10256","DOI":"10.1073\/pnas.0801336105","volume":"105","author":"UB Hendgen-Cotta","year":"2008","unstructured":"Hendgen-Cotta UB, Merx MW, Shiva S et al (2008) Nitrite reductase activity of myoglobin regulates respiration and cellular viability in myocardial ischemia-reperfusion injury. Proc Natl Acad Sci USA 105:10256\u201310261. doi: 10.1073\/pnas.0801336105","journal-title":"Proc Natl Acad Sci USA"},{"key":"2519_CR88","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.cbpb.2004.05.003","volume":"138","author":"RW Davis","year":"2004","unstructured":"Davis RW, Polasek L, Watson R et al (2004) The diving paradox: new insights into the role of the dive response in air-breathing vertebrates. Comp Biochem Physiol Part A Mol Integr Physiol 138:263\u2013268. doi: 10.1016\/j.cbpb.2004.05.003","journal-title":"Comp Biochem Physiol Part A Mol Integr Physiol"},{"key":"2519_CR89","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.cbpa.2012.10.010","volume":"164","author":"P Dasmeh","year":"2013","unstructured":"Dasmeh P, Davis RW, Kepp KP (2013) Aerobic dive limits of seals with mutant myoglobin using combined thermochemical and physiological data. Comp Biochem Physiol Part A Mol Integr Physiol 164:119\u2013128. doi: 10.1016\/j.cbpa.2012.10.010","journal-title":"Comp Biochem Physiol Part A Mol Integr Physiol"},{"key":"2519_CR90","doi-asserted-by":"publisher","first-page":"1234192","DOI":"10.1126\/science.1234192","volume":"340","author":"S Mirceta","year":"2013","unstructured":"Mirceta S, Signore AV, Burns JM et al (2013) Evolution of mammalian diving capacity traced by myoglobin net surface charge. Science 340:1234192. doi: 10.1126\/science.1234192","journal-title":"Science"},{"key":"2519_CR91","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1093\/genetics\/47.6.713","volume":"47","author":"M Kimura","year":"1962","unstructured":"Kimura M (1962) On the probability of fixation of mutant genes in a population. Genetics 47:713","journal-title":"Genetics"},{"key":"2519_CR92","doi-asserted-by":"publisher","first-page":"2949","DOI":"10.1093\/molbev\/mss105","volume":"29","author":"M Phifer-Rixey","year":"2012","unstructured":"Phifer-Rixey M, Bonhomme F, Boursot P et al (2012) Adaptive evolution and effective population size in wild house mice. Mol Biol Evol 29:2949\u20132955. doi: 10.1093\/molbev\/mss105","journal-title":"Mol Biol Evol"},{"key":"2519_CR93","doi-asserted-by":"crossref","first-page":"e4396","DOI":"10.1371\/journal.pone.0004396","volume":"4","author":"G Piganeau","year":"2009","unstructured":"Piganeau G, Eyre-Walker A (2009) Evidence for variation in the effective population size of animal mitochondrial DNA. PLoS One 4:e4396","journal-title":"PLoS One"},{"key":"2519_CR94","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1196\/annals.1354.010","volume":"1067","author":"L Demetrius","year":"2006","unstructured":"Demetrius L (2006) Aging in mouse and human systems: a comparative study. Ann N Y Acad Sci 1067:66\u201382. doi: 10.1196\/annals.1354.010","journal-title":"Ann N Y Acad Sci"},{"key":"2519_CR95","doi-asserted-by":"crossref","first-page":"e68029","DOI":"10.1371\/journal.pone.0068029","volume":"8","author":"SI Perez","year":"2013","unstructured":"Perez SI, Tejedor MF, Novo NM, Aristide L (2013) Divergence times and the evolutionary radiation of new world monkeys (Platyrrhini, Primates): an analysis of fossil and molecular data. PLoS One 8:e68029","journal-title":"PLoS One"},{"key":"2519_CR96","doi-asserted-by":"publisher","first-page":"4046","DOI":"10.1073\/pnas.0436428100","volume":"100","author":"CR White","year":"2003","unstructured":"White CR, Seymour RS (2003) Mammalian basal metabolic rate is proportional to body mass2\/3. Proc Natl Acad Sci 100:4046\u20134049. doi: 10.1073\/pnas.0436428100","journal-title":"Proc Natl Acad Sci"},{"key":"2519_CR97","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1126\/science.1070587","volume":"295","author":"PA Marquet","year":"2002","unstructured":"Marquet PA (2002) Of predators, prey, and power laws. Science 295:2229\u20132230","journal-title":"Science"},{"key":"2519_CR98","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1073\/pnas.022629899","volume":"99","author":"S Kumar","year":"2002","unstructured":"Kumar S, Subramanian S (2002) Mutation rates in mammalian genomes. Proc Natl Acad Sci 99:803\u2013808","journal-title":"Proc Natl Acad Sci"},{"key":"2519_CR99","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1104\/pp.101.1.7","volume":"101","author":"JG Scandalios","year":"1993","unstructured":"Scandalios JG (1993) Oxygen stress and superoxide dismutases. Plant Physiol 101:7\u201312","journal-title":"Plant Physiol"},{"key":"2519_CR100","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.cell.2008.05.042","volume":"134","author":"DA Drummond","year":"2008","unstructured":"Drummond DA, Wilke CO (2008) Mistranslation-induced protein misfolding as a dominant constraint on coding-sequence evolution. Cell 134:341\u2013352. doi: 10.1016\/j.cell.2008.05.042","journal-title":"Cell"},{"key":"2519_CR101","doi-asserted-by":"publisher","first-page":"e90504","DOI":"10.1371\/journal.pone.0090504","volume":"9","author":"KP Kepp","year":"2014","unstructured":"Kepp KP, Dasmeh P (2014) A model of proteostatic energy cost and its use in analysis of proteome trends and sequence evolution. PLoS One 9:e90504. doi: 10.1371\/journal.pone.0090504","journal-title":"PLoS One"},{"key":"2519_CR102","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.celrep.2012.06.022","volume":"2","author":"AWR Serohijos","year":"2012","unstructured":"Serohijos AWR, Rimas Z, Shakhnovich EI (2012) Protein biophysics explains why highly abundant proteins evolve slowly. Cell Rep 2:249\u2013256. doi: 10.1016\/j.celrep.2012.06.022","journal-title":"Cell Rep"},{"key":"2519_CR103","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.tree.2013.09.009","volume":"29","author":"R Lanfear","year":"2014","unstructured":"Lanfear R, Kokko H, Eyre-Walker A (2014) Population size and the rate of evolution. Trends Ecol Evol 29:33\u201341. doi: 10.1016\/j.tree.2013.09.009","journal-title":"Trends Ecol Evol"},{"key":"2519_CR104","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1017\/S0305004100015644","volume":"23","author":"JBS Haldane","year":"1927","unstructured":"Haldane JBS (1927) A mathematical theory of natural and artificial selection, part V: selection and mutation. Math Proc Cambridge Philos Soc 23:838\u2013844","journal-title":"Math Proc Cambridge Philos Soc"},{"key":"2519_CR105","doi-asserted-by":"publisher","first-page":"3217","DOI":"10.1093\/hmg\/ddp260","volume":"18","author":"M Prudencio","year":"2009","unstructured":"Prudencio M, Hart PJ, Borchelt DR, Andersen PM (2009) Variation in aggregation propensities among ALS-associated variants of SOD1: correlation to human disease. Hum Mol Genet 18:3217\u20133226. doi: 10.1093\/hmg\/ddp260","journal-title":"Hum Mol Genet"},{"key":"2519_CR106","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1038\/nature02261","volume":"426","author":"CM Dobson","year":"2003","unstructured":"Dobson CM (2003) Protein folding and misfolding. Nature 426:884\u2013890. doi: 10.1038\/nature02261","journal-title":"Nature"},{"key":"2519_CR107","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1016\/j.jmb.2010.04.019","volume":"399","author":"C M\u00fcnch","year":"2010","unstructured":"M\u00fcnch C, Bertolotti A (2010) Exposure of hydrophobic surfaces initiates aggregation of diverse ALS-causing superoxide dismutase-1 mutants. J Mol Biol 399:512\u2013525. doi: 10.1016\/j.jmb.2010.04.019","journal-title":"J Mol Biol"},{"key":"2519_CR108","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.nbd.2010.04.008","volume":"39","author":"S Gagliardi","year":"2010","unstructured":"Gagliardi S, Cova E, Davin A et al (2010) SOD1 mRNA expression in sporadic amyotrophic lateral sclerosis. Neurobiol Dis 39:198\u2013203. doi: 10.1016\/j.nbd.2010.04.008","journal-title":"Neurobiol Dis"},{"key":"2519_CR109","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1111\/gtc.12125","volume":"19","author":"A Kitamura","year":"2014","unstructured":"Kitamura A, Inada N, Kubota H et al (2014) Dysregulation of the proteasome increases the toxicity of ALS-linked mutant SOD1. Genes Cells 19:209\u2013224. doi: 10.1111\/gtc.12125","journal-title":"Genes Cells"},{"key":"2519_CR110","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.1016\/j.neurobiolaging.2013.11.025","volume":"35","author":"SP Allen","year":"2014","unstructured":"Allen SP, Rajan S, Duffy L et al (2014) Superoxide dismutase 1 mutation in a cellular model of amyotrophic lateral sclerosis shifts energy generation from oxidative phosphorylation to glycolysis. Neurobiol Aging 35:1499\u20131509. doi: 10.1016\/j.neurobiolaging.2013.11.025","journal-title":"Neurobiol Aging"},{"key":"2519_CR111","doi-asserted-by":"publisher","first-page":"e68256","DOI":"10.1371\/journal.pone.0068256","volume":"8","author":"K Richardson","year":"2013","unstructured":"Richardson K, Allen SP, Mortiboys H et al (2013) The effect of SOD1 mutation on cellular bioenergetic profile and viability in response to oxidative stress and influence of mutation-type. PLoS One 8:e68256. doi: 10.1371\/journal.pone.0068256","journal-title":"PLoS One"},{"key":"2519_CR112","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1007\/s00415-009-5100-z","volume":"256","author":"C Bouteloup","year":"2009","unstructured":"Bouteloup C, Desport J-C, Clavelou P et al (2009) Hypermetabolism in ALS patients: an early and persistent phenomenon. J Neurol 256:1236\u20131242. doi: 10.1007\/s00415-009-5100-z","journal-title":"J Neurol"},{"key":"2519_CR113","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1093\/molbev\/msi126","volume":"22","author":"A Wagner","year":"2005","unstructured":"Wagner A (2005) Energy constraints on the evolution of gene expression. Mol Biol Evol 22:1365\u20131374. doi: 10.1093\/molbev\/msi126","journal-title":"Mol Biol Evol"},{"key":"2519_CR114","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1093\/molbev\/msl029","volume":"23","author":"EM Heizer","year":"2006","unstructured":"Heizer EM, Raiford DW, Raymer ML et al (2006) Amino acid cost and codon-usage biases in 6 prokaryotic genomes: a whole-genome analysis. Mol Biol Evol 23:1670\u20131680. doi: 10.1093\/molbev\/msl029","journal-title":"Mol Biol Evol"},{"key":"2519_CR115","doi-asserted-by":"publisher","first-page":"14338","DOI":"10.1073\/pnas.0504070102","volume":"102","author":"DA Drummond","year":"2005","unstructured":"Drummond DA, Bloom JD, Adami C et al (2005) Why highly expressed proteins evolve slowly. Proc Natl Acad Sci USA 102:14338\u201314343. doi: 10.1073\/pnas.0504070102","journal-title":"Proc Natl Acad Sci USA"},{"key":"2519_CR116","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1098\/rstb.1991.0028","volume":"332","author":"TB Kirkwood","year":"1991","unstructured":"Kirkwood TB, Rose MR (1991) Evolution of senescence: late survival sacrificed for reproduction. Philos Trans R Soc Lond B Biol Sci 332:15\u201324. doi: 10.1098\/rstb.1991.0028","journal-title":"Philos Trans R Soc Lond B Biol Sci"}],"container-title":["Cellular and Molecular Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00018-017-2519-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-017-2519-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-017-2519-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T08:29:50Z","timestamp":1658910590000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00018-017-2519-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,7]]},"references-count":116,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["2519"],"URL":"https:\/\/doi.org\/10.1007\/s00018-017-2519-8","relation":{},"ISSN":["1420-682X","1420-9071"],"issn-type":[{"value":"1420-682X","type":"print"},{"value":"1420-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,7]]}}}