{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T11:00:28Z","timestamp":1793876428833,"version":"4.7.0"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"23","license":[{"start":{"date-parts":[[2017,9,8]],"date-time":"2017-09-08T00:00:00Z","timestamp":1504828800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell. Mol. Life Sci."],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1007\/s00018-017-2648-0","type":"journal-article","created":{"date-parts":[[2017,9,11]],"date-time":"2017-09-11T14:17:13Z","timestamp":1505139433000},"page":"4293-4303","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":148,"title":["Periostin in inflammation and allergy"],"prefix":"10.1007","volume":"74","author":[{"given":"Kenji","family":"Izuhara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Nunomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Nanri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junya","family":"Ono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasutaka","family":"Mitamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohito","family":"Yoshihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,9,8]]},"reference":[{"key":"2648_CR1","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1007\/s00018-013-1494-y","volume":"71","author":"SJ Conway","year":"2014","unstructured":"Conway SJ, Izuhara K, Kudo Y, Litvin J, Markwald R, Ouyang G, Arron JR, Holweg CT, Kudo A (2014) The role of periostin in tissue remodeling across health and disease. Cell Mol Life Sci 71:1279\u20131288. doi:\n                        10.1007\/s00018-013-1494-y","journal-title":"Cell Mol Life Sci"},{"key":"2648_CR2","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1111\/j.1600-0625.2012.01454.x","volume":"21","author":"K Ontsuka","year":"2012","unstructured":"Ontsuka K, Kotobuki Y, Shiraishi H, Serada S, Ohta S, Tanemura A, Yang L, Fujimoto M, Arima K, Suzuki S, Murota H, Toda S, Kudo A, Conway SJ, Narisawa Y, Katayama I, Izuhara K, Naka T (2012) Periostin, a matricellular protein, accelerates cutaneous wound repair by activating dermal fibroblasts. Exp Dermatol 21:331\u2013336. doi:\n                        10.1111\/j.1600-0625.2012.01454.x","journal-title":"Exp Dermatol"},{"key":"2648_CR3","doi-asserted-by":"publisher","first-page":"e18410","DOI":"10.1371\/journal.pone.0018410","volume":"6","author":"T Nishiyama","year":"2011","unstructured":"Nishiyama T, Kii I, Kashima TG, Kikuchi Y, Ohazama A, Shimazaki M, Fukayama M, Kudo A (2011) Delayed re-epithelialization in periostin-deficient mice during cutaneous wound healing. PLoS One 6:e18410. doi:\n                        10.1371\/journal.pone.0018410","journal-title":"PLoS One"},{"key":"2648_CR4","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1242\/jcs.087841","volume":"125","author":"CG Elliott","year":"2012","unstructured":"Elliott CG, Wang J, Guo X, Xu SW, Eastwood M, Guan J, Leask A, Conway SJ, Hamilton DW (2012) Periostin modulates myofibroblast differentiation during full-thickness cutaneous wound repair. J Cell Sci 125:121\u2013132. doi:\n                        10.1242\/jcs.087841","journal-title":"J Cell Sci"},{"key":"2648_CR5","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1006\/cyto.2002.1972","volume":"19","author":"N Yuyama","year":"2002","unstructured":"Yuyama N, Davies DE, Akaiwa M, Matsui K, Hamasaki Y, Suminami Y, Yoshida NL, Maeda M, Pandit A, Lordan JL, Kamogawa Y, Arima K, Nagumo F, Sugimachi M, Berger A, Richards I, Roberds SL, Yamashita T, Kishi F, Kato H, Arai K, Ohshima K, Tadano J, Hamasaki N, Miyatake S, Sugita Y, Holgate ST, Izuhara K (2002) Analysis of novel disease-related genes in bronchial asthma. Cytokine 19:287\u2013296","journal-title":"Cytokine"},{"key":"2648_CR6","doi-asserted-by":"crossref","first-page":"263","DOI":"10.2174\/1568010023344661","volume":"1","author":"K Izuhara","year":"2002","unstructured":"Izuhara K, Arima K, Yasunaga S (2002) IL-4 and IL-13: their pathological roles in allergic diseases and their potential in developing new therapies. Curr Drug Targets Inflamm Allergy 1:263\u2013269","journal-title":"Curr Drug Targets Inflamm Allergy"},{"key":"2648_CR7","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.2174\/092986706777935140","volume":"13","author":"K Izuhara","year":"2006","unstructured":"Izuhara K, Arima K, Kanaji S, Ohta S, Kanaji T (2006) IL-13: a promising therapeutic target for bronchial asthma. Curr Med Chem 13:2291\u20132298","journal-title":"Curr Med Chem"},{"key":"2648_CR8","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/s12026-011-8205-2","volume":"50","author":"S Goenka","year":"2011","unstructured":"Goenka S, Kaplan MH (2011) Transcriptional regulation by STAT6. Immunol Res 50:87\u201396. doi:\n                        10.1007\/s12026-011-8205-2","journal-title":"Immunol Res"},{"key":"2648_CR9","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1126\/science.1221064","volume":"337","author":"B Pulendran","year":"2012","unstructured":"Pulendran B, Artis D (2012) New paradigms in type 2 immunity. Science 337:431\u2013435. doi:\n                        10.1126\/science.1221064","journal-title":"Science"},{"key":"2648_CR10","doi-asserted-by":"publisher","first-page":"491","DOI":"10.4168\/aair.2016.8.6.491","volume":"8","author":"K Izuhara","year":"2016","unstructured":"Izuhara K, Ohta S, Ono J (2016) Using periostin as a biomarker in the treatment of asthma. Allergy Asthma Immunol Res 8:491\u2013498. doi:\n                        10.4168\/aair.2016.8.6.491","journal-title":"Allergy Asthma Immunol Res"},{"key":"2648_CR11","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/j.alit.2016.12.002","volume":"66","author":"M Furue","year":"2017","unstructured":"Furue M, Chiba T, Tsuji G, Ulzii D, Kido-Nakahara M, Nakahara T, Kadono T (2017) Atopic dermatitis: immune deviation, barrier dysfunction, IgE autoreactivity and new therapies. Allergol Int 66:398\u2013403. doi:\n                        10.1016\/j.alit.2016.12.002","journal-title":"Allergol Int"},{"key":"2648_CR12","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.alit.2017.04.006","volume":"66","author":"M Kubo","year":"2017","unstructured":"Kubo M (2017) T follicular helper and TH2 cells in allergic responses. Allergol Int 66:377\u2013381. doi:\n                        10.1016\/j.alit.2017.04.006","journal-title":"Allergol Int"},{"key":"2648_CR13","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.alit.2015.03.004","volume":"64","author":"H Kabata","year":"2015","unstructured":"Kabata H, Moro K, Koyasu S, Asano K (2015) Group 2 innate lymphoid cells and asthma. Allergol Int 64:227\u2013234. doi:\n                        10.1016\/j.alit.2015.03.004","journal-title":"Allergol Int"},{"key":"2648_CR14","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1016\/j.alit.2017.04.007","volume":"66","author":"K Miyake","year":"2017","unstructured":"Miyake K, Karasuyama H (2017) Emerging roles of basophils in allergic inflammation. Allergol Int 66:382\u2013391. doi:\n                        10.1016\/j.alit.2017.04.007","journal-title":"Allergol Int"},{"key":"2648_CR15","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.jaci.2006.02.046","volume":"118","author":"G Takayama","year":"2006","unstructured":"Takayama G, Arima K, Kanaji T, Toda S, Tanaka H, Shoji S, McKenzie AN, Nagai H, Hotokebuchi T, Izuhara K (2006) Periostin: a novel component of subepithelial fibrosis of bronchial asthma downstream of IL-4 and IL-13 signals. J Allergy Clin Immunol 118:98\u2013104. doi:\n                        10.1016\/j.jaci.2006.02.046","journal-title":"J Allergy Clin Immunol"},{"key":"2648_CR16","doi-asserted-by":"publisher","first-page":"2590","DOI":"10.1172\/JCI58978","volume":"122","author":"M Masuoka","year":"2012","unstructured":"Masuoka M, Shiraishi H, Ohta S, Suzuki S, Arima K, Aoki S, Toda S, Inagaki N, Kurihara Y, Hayashida S, Takeuchi S, Koike K, Ono J, Noshiro H, Furue M, Conway SJ, Narisawa Y, Izuhara K (2012) Periostin promotes chronic allergic inflammation in response to Th2 cytokines. J Clin Invest 122:2590\u20132600. doi:\n                        10.1172\/JCI58978","journal-title":"J Clin Invest"},{"key":"2648_CR17","doi-asserted-by":"publisher","first-page":"589","DOI":"10.2332\/allergolint.11-OA-0370","volume":"61","author":"A Ishida","year":"2012","unstructured":"Ishida A, Ohta N, Suzuki Y, Kakehata S, Okubo K, Ikeda H, Shiraishi H, Izuhara K (2012) Expression of pendrin and periostin in allergic rhinitis and chronic rhinosinusitis. Allergol Int 61:589\u2013595. doi:\n                        10.2332\/allergolint.11-OA-0370","journal-title":"Allergol Int"},{"key":"2648_CR18","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1097\/MLG.0b013e31816b4b6f","volume":"118","author":"KM Stankovic","year":"2008","unstructured":"Stankovic KM, Goldsztein H, Reh DD, Platt MP, Metson R (2008) Gene expression profiling of nasal polyps associated with chronic sinusitis and aspirin-sensitive asthma. Laryngoscope 118:881\u2013889. doi:\n                        10.1097\/MLG.0b013e31816b4b6f","journal-title":"Laryngoscope"},{"issue":"459\u2013467","key":"2648_CR19","doi-asserted-by":"publisher","first-page":"e2","DOI":"10.1016\/j.jaci.2015.11.039","volume":"138","author":"H Fujishima","year":"2016","unstructured":"Fujishima H, Okada N, Matsumoto K, Fukagawa K, Igarashi A, Matsuda A, Ono J, Ohta S, Mukai H, Yoshikawa M, Izuhara K (2016) The usefulness of measuring tear periostin for the diagnosis and management of ocular allergic diseases. J Allergy Clin Immunol 138(459\u2013467):e2. doi:\n                        10.1016\/j.jaci.2015.11.039","journal-title":"J Allergy Clin Immunol"},{"key":"2648_CR20","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1038\/mi.2008.15","volume":"1","author":"C Blanchard","year":"2008","unstructured":"Blanchard C, Mingler MK, McBride M, Putnam PE, Collins MH, Chang G, Stringer K, Abonia JP, Molkentin JD, Rothenberg ME (2008) Periostin facilitates eosinophil tissue infiltration in allergic lung and esophageal responses. Mucosal Immunol 1:289\u2013296. doi:\n                        10.1038\/mi.2008.15","journal-title":"Mucosal Immunol"},{"key":"2648_CR21","doi-asserted-by":"publisher","first-page":"14170","DOI":"10.1073\/pnas.1009426107","volume":"107","author":"SS Sidhu","year":"2010","unstructured":"Sidhu SS, Yuan S, Innes AL, Kerr S, Woodruff PG, Hou L, Muller SJ, Fahy JV (2010) Roles of epithelial cell-derived periostin in TGF-\u03b2 activation, collagen production, and collagen gel elasticity in asthma. Proc Natl Acad Sci USA 107:14170\u201314175. doi:\n                        10.1073\/pnas.1009426107","journal-title":"Proc Natl Acad Sci USA"},{"key":"2648_CR22","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1111\/all.12240","volume":"68","author":"T Shoda","year":"2013","unstructured":"Shoda T, Futamura K, Kobayashi F, Saito H, Matsumoto K, Matsuda A (2013) Cell type-dependent effects of corticosteroid on periostin production by primary human tissue cells. Allergy 68:1467\u20131470. doi:\n                        10.1111\/all.12240","journal-title":"Allergy"},{"key":"2648_CR23","doi-asserted-by":"publisher","first-page":"4959","DOI":"10.4049\/jimmunol.1002359","volume":"186","author":"S Sehra","year":"2011","unstructured":"Sehra S, Yao W, Nguyen ET, Ahyi AN, Tuana FM, Ahlfeld SK, Snider P, Tepper RS, Petrache I, Conway SJ, Kaplan MH (2011) Periostin regulates goblet cell metaplasia in a model of allergic airway inflammation. J Immunol 186:4959\u20134966. doi:\n                        10.4049\/jimmunol.1002359","journal-title":"J Immunol"},{"key":"2648_CR24","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1111\/j.1365-2222.2011.03840.x","volume":"42","author":"ED Gordon","year":"2012","unstructured":"Gordon ED, Sidhu SS, Wang ZE, Woodruff PG, Yuan S, Solon MC, Conway SJ, Huang X, Locksley RM, Fahy JV (2012) A protective role for periostin and TGF-\u03b2 in IgE-mediated allergy and airway hyperresponsiveness. Clin Exp Allergy 42:144\u2013155. doi:\n                        10.1111\/j.1365-2222.2011.03840.x","journal-title":"Clin Exp Allergy"},{"key":"2648_CR25","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1016\/j.jaci.2014.05.029","volume":"134","author":"JK Bentley","year":"2014","unstructured":"Bentley JK, Chen Q, Hong JY, Popova AP, Lei J, Moore BB, Hershenson MB (2014) Periostin is required for maximal airways inflammation and hyperresponsiveness in mice. J Allergy Clin Immunol 134:1433\u20131442. doi:\n                        10.1016\/j.jaci.2014.05.029","journal-title":"J Allergy Clin Immunol"},{"key":"2648_CR26","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1164\/rccm.201403-0562LE","volume":"190","author":"Y Kanemitsu","year":"2014","unstructured":"Kanemitsu Y, Ito I, Niimi A, Izuhara K, Ohta S, Ono J, Iwata T, Matsumoto H, Mishima M (2014) Osteopontin and periostin are associated with a 20-year decline of pulmonary function in patients with asthma. Am J Respir Crit Care Med 190:472\u2013474. doi:\n                        10.1164\/rccm.201403-0562LE","journal-title":"Am J Respir Crit Care Med"},{"key":"2648_CR27","doi-asserted-by":"publisher","first-page":"563","DOI":"10.2332\/allergolint.10-OA-0297","volume":"61","author":"H Shiraishi","year":"2012","unstructured":"Shiraishi H, Masuoka M, Ohta S, Suzuki S, Arima K, Taniguchi K, Aoki S, Toda S, Yoshimoto T, Inagaki N, Conway SJ, Narisawa Y, Izuhara K (2012) Periostin contributes to the pathogenesis of atopic dermatitis by inducing TSLP production from keratinocytes. Allergol Int 61:563\u2013572. doi:\n                        10.2332\/allergolint.10-OA-0297","journal-title":"Allergol Int"},{"key":"2648_CR28","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1111\/bjd.12943","volume":"171","author":"K Kou","year":"2014","unstructured":"Kou K, Okawa T, Yamaguchi Y, Ono J, Inoue Y, Kohno M, Matsukura S, Kambara T, Ohta S, Izuhara K, Aihara M (2014) Periostin levels correlate disease severity and chronicity in patients with atopic dermatitis. Br J Dermatol 171:283\u2013291. doi:\n                        10.1111\/bjd.12943","journal-title":"Br J Dermatol"},{"key":"2648_CR29","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1038\/jid.2013.500","volume":"134","author":"K Taniguchi","year":"2014","unstructured":"Taniguchi K, Arima K, Masuoka M, Ohta S, Shiraishi H, Ontsuka K, Suzuki S, Inamitsu M, Yamamoto K, Simmons O, Toda S, Conway SJ, Hamasaki Y, Izuhara K (2014) Periostin controls keratinocyte proliferation and differentiation by interacting with the paracrine IL-1\u03b1\/IL-6 loop. J Invest Dermatol 134:1295\u20131304. doi:\n                        10.1038\/jid.2013.500","journal-title":"J Invest Dermatol"},{"issue":"1449\u20131452","key":"2648_CR30","doi-asserted-by":"publisher","first-page":"e5","DOI":"10.1016\/j.jaci.2016.05.020","volume":"138","author":"T Noguchi","year":"2016","unstructured":"Noguchi T, Nakagome K, Kobayashi T, Uchida Y, Soma T, Nakamoto H, Nagata M (2016) Periostin upregulates the effector functions of eosinophils. J Allergy Clin Immunol 138(1449\u20131452):e5. doi:\n                        10.1016\/j.jaci.2016.05.020","journal-title":"J Allergy Clin Immunol"},{"issue":"Suppl","key":"2648_CR31","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1016\/j.alit.2015.04.012","volume":"64","author":"K Izuhara","year":"2015","unstructured":"Izuhara K, Matsumoto H, Ohta S, Ono J, Arima K, Ogawa M (2015) Recent developments regarding periostin in bronchial asthma. Allergol Int 64(Suppl):S3\u2013S10. doi:\n                        10.1016\/j.alit.2015.04.012","journal-title":"Allergol Int"},{"key":"2648_CR32","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.alit.2014.07.003","volume":"64","author":"M Matsusaka","year":"2015","unstructured":"Matsusaka M, Kabata H, Fukunaga K, Suzuki Y, Masaki K, Mochimaru T, Sakamaki F, Oyamada Y, Inoue T, Oguma T, Sayama K, Koh H, Nakamura M, Umeda A, Ono J, Ohta S, Izuhara K, Asano K, Betsuyaku T (2015) Phenotype of asthma related with high serum periostin levels. Allergol Int 64:175\u2013180. doi:\n                        10.1016\/j.alit.2014.07.003","journal-title":"Allergol Int"},{"key":"2648_CR33","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.anai.2014.06.014","volume":"113","author":"MA Kim","year":"2014","unstructured":"Kim MA, Izuhara K, Ohta S, Ono J, Yoon MK, Ban GY, Yoo HS, Shin YS, Ye YM, Nahm DH, Park HS (2014) Association of serum periostin with aspirin-exacerbated respiratory disease. Ann Allergy Asthma Immunol 113:314\u2013320. doi:\n                        10.1016\/j.anai.2014.06.014","journal-title":"Ann Allergy Asthma Immunol"},{"key":"2648_CR34","doi-asserted-by":"publisher","first-page":"2702","DOI":"10.1093\/ndt\/gfr670","volume":"27","author":"B Satirapoj","year":"2012","unstructured":"Satirapoj B, Wang Y, Chamberlin MP, Dai T, LaPage J, Phillips L, Nast CC, Adler SG (2012) Periostin: novel tissue and urinary biomarker of progressive renal injury induces a coordinated mesenchymal phenotype in tubular cells. Nephrol Dial Transplant 27:2702\u20132711. doi:\n                        10.1093\/ndt\/gfr670","journal-title":"Nephrol Dial Transplant"},{"key":"2648_CR35","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.transproceed.2013.07.069","volume":"46","author":"B Satirapoj","year":"2014","unstructured":"Satirapoj B, Witoon R, Ruangkanchanasetr P, Wantanasiri P, Charoenpitakchai M, Choovichian P (2014) Urine periostin as a biomarker of renal injury in chronic allograft nephropathy. Transplant Proc 46:135\u2013140. doi:\n                        10.1016\/j.transproceed.2013.07.069","journal-title":"Transplant Proc"},{"key":"2648_CR36","doi-asserted-by":"publisher","first-page":"e0124055","DOI":"10.1371\/journal.pone.0124055","volume":"10","author":"B Satirapoj","year":"2015","unstructured":"Satirapoj B, Tassanasorn S, Charoenpitakchai M, Supasyndh O (2015) Periostin as a tissue and urinary biomarker of renal injury in type 2 diabetes mellitus. PLoS One 10:e0124055. doi:\n                        10.1371\/journal.pone.0124055","journal-title":"PLoS One"},{"key":"2648_CR37","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1111\/all.12580","volume":"70","author":"I Bobolea","year":"2015","unstructured":"Bobolea I, Barranco P, Del Pozo V, Romero D, Sanz V, Lopez-Carrasco V, Canabal J, Villasante C, Quirce S (2015) Sputum periostin in patients with different severe asthma phenotypes. Allergy 70:540\u2013546. doi:\n                        10.1111\/all.12580","journal-title":"Allergy"},{"key":"2648_CR38","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/s12890-016-0230-4","volume":"16","author":"JL Simpson","year":"2016","unstructured":"Simpson JL, Yang IA, Upham JW, Reynolds PN, Hodge S, James AL, Jenkins C, Peters MJ, Jia G, Holweg CT, Gibson PG (2016) Periostin levels and eosinophilic inflammation in poorly-controlled asthma. BMC Pulm Med 16:67. doi:\n                        10.1186\/s12890-016-0230-4","journal-title":"BMC Pulm Med"},{"key":"2648_CR39","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1111\/pai.12575","volume":"27","author":"T Inoue","year":"2016","unstructured":"Inoue T, Akashi K, Watanabe M, Ikeda Y, Ashizuka S, Motoki T, Suzuki R, Sagara N, Yanagida N, Sato S, Ebisawa M, Ohta S, Ono J, Izuhara K, Katsunuma T (2016) Periostin as a biomarker for the diagnosis of pediatric asthma. Pediatr Allergy Immunol 27:521\u2013526. doi:\n                        10.1111\/pai.12575","journal-title":"Pediatr Allergy Immunol"},{"key":"2648_CR40","doi-asserted-by":"publisher","DOI":"10.1111\/all.13181","author":"A James","year":"2017","unstructured":"James A, Janson C, Malinovschi A, Holweg C, Alving K, Ono J, Ohta S, Ek A, Middelveld R, Dahlen B, Forsberg B, Izuhara K, Dahlen SE (2017) Serum periostin relates to type-2 inflammation and lung function in asthma; data from the large population-based cohort Swedish GA(2)LEN. Allergy. doi:\n                        10.1111\/all.13181\n                        \n                     (in press)","journal-title":"Allergy"},{"key":"2648_CR41","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.jaci.2013.04.050","volume":"132","author":"Y Kanemitsu","year":"2013","unstructured":"Kanemitsu Y, Matsumoto H, Izuhara K, Tohda Y, Kita H, Horiguchi T, Kuwabara K, Tomii K, Otsuka K, Fujimura M, Ohkura N, Tomita K, Yokoyama A, Ohnishi H, Nakano Y, Oguma T, Hozawa S, Nagasaki T, Ito I, Inoue H, Tajiri T, Iwata T, Izuhara Y, Ono J, Ohta S, Tamari M, Hirota T, Yokoyama T, Niimi A, Mishima M (2013) Increased periostin associates with greater airflow limitation in patients receiving inhaled corticosteroids. J Allergy Clin Immunol 132:305\u2013312. doi:\n                        10.1016\/j.jaci.2013.04.050","journal-title":"J Allergy Clin Immunol"},{"key":"2648_CR42","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1164\/rccm.201407-1290LE","volume":"190","author":"T Nagasaki","year":"2014","unstructured":"Nagasaki T, Matsumoto H, Kanemitsu Y, Izuhara K, Tohda Y, Horiguchi T, Kita H, Tomii K, Fujimura M, Yokoyama A, Nakano Y, Hozawa S, Ito I, Oguma T, Izuhara Y, Tajiri T, Iwata T, Ono J, Ohta S, Yokoyama T, Niimi A, Mishima M (2014) Using exhaled nitric oxide and serum periostin as a composite marker to identify severe\/steroid-insensitive asthma. Am J Respir Crit Care Med 190:1449\u20131452. doi:\n                        10.1164\/rccm.201407-1290LE","journal-title":"Am J Respir Crit Care Med"},{"key":"2648_CR43","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.jaci.2015.11.020","volume":"138","author":"TS Hinks","year":"2016","unstructured":"Hinks TS, Brown T, Lau LC, Rupani H, Barber C, Elliott S, Ward JA, Ono J, Ohta S, Izuhara K, Djukanovic R, Kurukulaaratchy RJ, Chauhan A, Howarth PH (2016) Multidimensional endotyping in patients with severe asthma reveals inflammatory heterogeneity in matrix metalloproteinases and chitinase 3-like protein 1. J Allergy Clin Immunol 138:61\u201375. doi:\n                        10.1016\/j.jaci.2015.11.020","journal-title":"J Allergy Clin Immunol"},{"key":"2648_CR44","doi-asserted-by":"publisher","first-page":"1904","DOI":"10.1016\/j.jaci.2015.12.1346","volume":"137","author":"MW Johansson","year":"2016","unstructured":"Johansson MW, Evans MD, Crisafi GM, Holweg CT, Matthews JG, Jarjour NN (2016) Serum periostin is associated with type 2 immunity in severe asthma. J Allergy Clin Immunol 137:1904\u20131907. doi:\n                        10.1016\/j.jaci.2015.12.1346","journal-title":"J Allergy Clin Immunol"},{"key":"2648_CR45","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1111\/resp.12687","volume":"21","author":"M Hoshino","year":"2016","unstructured":"Hoshino M, Ohtawa J, Akitsu K (2016) Effect of treatment with inhaled corticosteroid on serum periostin levels in asthma. Respirology 21:297\u2013303. doi:\n                        10.1111\/resp.12687","journal-title":"Respirology"},{"key":"2648_CR46","doi-asserted-by":"publisher","first-page":"97","DOI":"10.4137\/bmi.s12537","volume":"8","author":"G Kato","year":"2013","unstructured":"Kato G, Takahashi K, Izuhara K, Komiya K, Kimura S, Hayashi S (2013) Markers that can reflect asthmatic activity before and after reduction of inhaled corticosteroids: a pilot study. Biomark Insights 8:97\u2013105. doi:\n                        10.4137\/bmi.s12537","journal-title":"Biomark Insights"},{"key":"2648_CR47","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1056\/NEJMoa1106469","volume":"365","author":"J Corren","year":"2011","unstructured":"Corren J, Lemanske RF, Hanania NA, Korenblat PE, Parsey MV, Arron JR, Harris JM, Scheerens H, Wu LC, Su Z, Mosesova S, Eisner MD, Bohen SP, Matthews JG (2011) Lebrikizumab treatment in adults with asthma. N Engl J Med 365:1088\u20131098. doi:\n                        10.1056\/NEJMoa1106469","journal-title":"N Engl J Med"},{"key":"2648_CR48","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1136\/thoraxjnl-2014-206719","volume":"70","author":"NA Hanania","year":"2015","unstructured":"Hanania NA, Noonan M, Corren J, Korenblat P, Zheng Y, Fischer SK, Cheu M, Putnam WS, Murray E, Scheerens H, Holweg CT, Maciuca R, Gray S, Doyle R, McClintock D, Olsson J, Matthews JG, Yen K (2015) Lebrikizumab in moderate-to-severe asthma: pooled data from two randomised placebo-controlled studies. Thorax 70:748\u2013756. doi:\n                        10.1136\/thoraxjnl-2014-206719","journal-title":"Thorax"},{"key":"2648_CR49","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1016\/s2213-2600(16)30265-x","volume":"4","author":"NA Hanania","year":"2016","unstructured":"Hanania NA, Korenblat P, Chapman KR, Bateman ED, Kopecky P, Paggiaro P, Yokoyama A, Olsson J, Gray S, Holweg CT, Eisner M, Asare C, Fischer SK, Peng K, Putnam WS, Matthews JG (2016) Efficacy and safety of lebrikizumab in patients with uncontrolled asthma (LAVOLTA I and LAVOLTA II): replicate, phase 3, randomised, double-blind, placebo-controlled trials. Lancet Respir Med 4:781\u2013796. doi:\n                        10.1016\/s2213-2600(16)30265-x","journal-title":"Lancet Respir Med"},{"key":"2648_CR50","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1016\/s2213-2600(15)00197-6","volume":"3","author":"CE Brightling","year":"2015","unstructured":"Brightling CE, Chanez P, Leigh R, O\u2019Byrne PM, Korn S, She D, May RD, Streicher K, Ranade K, Piper E (2015) Efficacy and safety of tralokinumab in patients with severe uncontrolled asthma: a randomised, double-blind, placebo-controlled, phase 2b trial. Lancet Respir Med 3:692\u2013701. doi:\n                        10.1016\/s2213-2600(15)00197-6","journal-title":"Lancet Respir Med"},{"key":"2648_CR51","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1164\/rccm.201208-1414OC","volume":"187","author":"NA Hanania","year":"2013","unstructured":"Hanania NA, Wenzel S, Rosen K, Hsieh HJ, Mosesova S, Choy DF, Lal P, Arron JR, Harris JM, Busse W (2013) Exploring the effects of omalizumab in allergic asthma: an analysis of biomarkers in the EXTRA study. Am J Respir Crit Care Med 187:804\u2013811. doi:\n                        10.1164\/rccm.201208-1414OC","journal-title":"Am J Respir Crit Care Med"},{"key":"2648_CR52","doi-asserted-by":"publisher","first-page":"1472","DOI":"10.1111\/all.12922","volume":"71","author":"T Tajiri","year":"2016","unstructured":"Tajiri T, Matsumoto H, Gon Y, Ito R, Hashimoto S, Izuhara K, Suzukawa M, Ohta K, Ono J, Ohta S, Ito I, Oguma T, Inoue H, Iwata T, Kanemitsu Y, Nagasaki T, Niimi A, Mishima M (2016) Utility of serum periostin and free IgE levels in evaluating responsiveness to omalizumab in patients with severe asthma. Allergy 71:1472\u20131479. doi:\n                        10.1111\/all.12922","journal-title":"Allergy"},{"key":"2648_CR53","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1002\/alr.20031","volume":"1","author":"SM Daines","year":"2011","unstructured":"Daines SM, Wang Y, Orlandi RR (2011) Periostin and osteopontin are overexpressed in chronically inflamed sinuses. Int Forum Allergy Rhinol 1:101\u2013105. doi:\n                        10.1002\/alr.20031","journal-title":"Int Forum Allergy Rhinol"},{"key":"2648_CR54","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1002\/alr.21056","volume":"2","author":"W Zhang","year":"2012","unstructured":"Zhang W, Hubin G, Endam LM, Al-Mot S, Filali-Mouhim A, Desrosiers M (2012) Expression of the extracellular matrix gene periostin is increased in chronic rhinosinusitis and decreases following successful endoscopic sinus surgery. Int Forum Allergy Rhinol 2:471\u2013476. doi:\n                        10.1002\/alr.21056","journal-title":"Int Forum Allergy Rhinol"},{"key":"2648_CR55","doi-asserted-by":"publisher","first-page":"1700","DOI":"10.1016\/j.jaci.2015.09.005","volume":"136","author":"M Wang","year":"2015","unstructured":"Wang M, Wang X, Zhang N, Wang H, Li Y, Fan E, Zhang L, Zhang L, Bachert C (2015) Association of periostin expression with eosinophilic inflammation in nasal polyps. J Allergy Clin Immunol 136:1700\u20131703. doi:\n                        10.1016\/j.jaci.2015.09.005","journal-title":"J Allergy Clin Immunol"},{"key":"2648_CR56","doi-asserted-by":"publisher","first-page":"e41994","DOI":"10.1371\/journal.pone.0041994","volume":"7","author":"L Yang","year":"2012","unstructured":"Yang L, Serada S, Fujimoto M, Terao M, Kotobuki Y, Kitaba S, Matsui S, Kudo A, Naka T, Murota H, Katayama I (2012) Periostin facilitates skin sclerosis via PI3K\/Akt dependent mechanism in a mouse model of scleroderma. PLoS One 7:e41994. doi:\n                        10.1371\/journal.pone.0041994","journal-title":"PLoS One"},{"key":"2648_CR57","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1111\/bjd.12117","volume":"168","author":"Y Yamaguchi","year":"2013","unstructured":"Yamaguchi Y, Ono J, Masuoka M, Ohta S, Izuhara K, Ikezawa Z, Aihara M, Takahashi K (2013) Serum periostin levels are correlated with progressive skin sclerosis in patients with systemic sclerosis. Br J Dermatol 168:717\u2013725. doi:\n                        10.1111\/bjd.12117","journal-title":"Br J Dermatol"},{"key":"2648_CR58","doi-asserted-by":"publisher","first-page":"2437","DOI":"10.1002\/1529-0131(200011)43:11<2437::aid-anr10>3.0.co;2-u","volume":"43","author":"VD Steen","year":"2000","unstructured":"Steen VD, Medsger TA Jr (2000) Severe organ involvement in systemic sclerosis with diffuse scleroderma. Arthritis Rheum 43:2437\u20132444. doi:\n                        10.1002\/1529-0131(200011)43:11<2437:aid-anr10>3.0.co;2-u","journal-title":"Arthritis Rheum"},{"key":"2648_CR59","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1183\/09031936.00059810","volume":"37","author":"M Okamoto","year":"2011","unstructured":"Okamoto M, Hoshino T, Kitasato Y, Sakazaki Y, Kawayama T, Fujimoto K, Ohshima K, Shiraishi H, Uchida M, Ono J, Ohta S, Kato S, Izuhara K, Aizawa H (2011) Periostin, a matrix protein, is a novel biomarker for idiopathic interstitial pneumonias. Eur Respir J 37:1119\u20131127. doi:\n                        10.1183\/09031936.00059810","journal-title":"Eur Respir J"},{"key":"2648_CR60","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1165\/rcmb.2011-0115OC","volume":"46","author":"M Uchida","year":"2012","unstructured":"Uchida M, Shiraishi H, Ohta S, Arima K, Taniguchi K, Suzuki S, Okamoto M, Ahlfeld SK, Ohshima K, Kato S, Toda S, Sagara H, Aizawa H, Hoshino T, Conway SJ, Hayashi S, Izuhara K (2012) Periostin, a matricellular protein, plays a role in the induction of chemokines in pulmonary fibrosis. Am J Respir Cell Mol Biol 46:677\u2013686. doi:\n                        10.1165\/rcmb.2011-0115OC","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2648_CR61","doi-asserted-by":"publisher","first-page":"L1046","DOI":"10.1152\/ajplung.00139.2012","volume":"303","author":"PK Naik","year":"2012","unstructured":"Naik PK, Bozyk PD, Bentley JK, Popova AP, Birch CM, Wilke CA, Fry CD, White ES, Sisson TH, Tayob N, Carnemolla B, Orecchia P, Flaherty KR, Hershenson MB, Murray S, Martinez FJ, Moore BB (2012) Periostin promotes fibrosis and predicts progression in patients with idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 303:L1046\u2013L1056. doi:\n                        10.1152\/ajplung.00139.2012","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2648_CR62","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1038\/mi.2016.61","volume":"10","author":"SL Ashley","year":"2017","unstructured":"Ashley SL, Wilke CA, Kim KK, Moore BB (2017) Periostin regulates fibrocyte function to promote myofibroblast differentiation and lung fibrosis. Mucosal Immunol 10:341\u2013351. doi:\n                        10.1038\/mi.2016.61","journal-title":"Mucosal Immunol"},{"key":"2648_CR63","doi-asserted-by":"publisher","first-page":"e0174547","DOI":"10.1371\/journal.pone.0174547","volume":"12","author":"S Ohta","year":"2017","unstructured":"Ohta S, Okamoto M, Fujimoto K, Sakamoto N, Takahashi K, Yamamoto H, Kushima H, Ishii H, Akasaka K, Ono J, Kamei A, Azuma Y, Matsumoto H, Yamaguchi Y, Aihara M, Johkoh T, Kawaguchi A, Ichiki M, Sagara H, Kadota JI, Hanaoka M, Hayashi SI, Kohno S, Hoshino T, Izuhara K (2017) The usefulness of monomeric periostin as a biomarker for idiopathic pulmonary fibrosis. PLoS One 12:e0174547. doi:\n                        10.1371\/journal.pone.0174547","journal-title":"PLoS One"},{"key":"2648_CR64","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.resinv.2014.12.003","volume":"53","author":"M Tajiri","year":"2015","unstructured":"Tajiri M, Okamoto M, Fujimoto K, Johkoh T, Ono J, Tominaga M, Azuma K, Kawayama T, Ohta S, Izuhara K, Hoshino T (2015) Serum level of periostin can predict long-term outcome of idiopathic pulmonary fibrosis. Respir Investig 53:73\u201381. doi:\n                        10.1016\/j.resinv.2014.12.003","journal-title":"Respir Investig"},{"key":"2648_CR65","doi-asserted-by":"publisher","first-page":"e92111","DOI":"10.1371\/journal.pone.0092111","volume":"9","author":"T Nance","year":"2014","unstructured":"Nance T, Smith KS, Anaya V, Richardson R, Ho L, Pala M, Mostafavi S, Battle A, Feghali-Bostwick C, Rosen G, Montgomery SB (2014) Transcriptome analysis reveals differential splicing events in IPF lung tissue. PLoS One 9:e92111. doi:\n                        10.1371\/journal.pone.0092111","journal-title":"PLoS One"},{"key":"2648_CR66","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1165\/ajrcmb.24.3.4293","volume":"24","author":"F Takahashi","year":"2001","unstructured":"Takahashi F, Takahashi K, Okazaki T, Maeda K, Ienaga H, Maeda M, Kon S, Uede T, Fukuchi Y (2001) Role of osteopontin in the pathogenesis of bleomycin-induced pulmonary fibrosis. Am J Respir Cell Mol Biol 24:264\u2013271. doi:\n                        10.1165\/ajrcmb.24.3.4293","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2648_CR67","doi-asserted-by":"publisher","first-page":"7851","DOI":"10.1158\/1078-0432.ccr-05-0262","volume":"11","author":"DG McNeel","year":"2005","unstructured":"McNeel DG, Eickhoff J, Lee FT, King DM, Alberti D, Thomas JP, Friedl A, Kolesar J, Marnocha R, Volkman J, Zhang J, Hammershaimb L, Zwiebel JA, Wilding G (2005) Phase I trial of a monoclonal antibody specific for \u03b1v\u03b23 integrin (MEDI-522) in patients with advanced malignancies, including an assessment of effect on tumor perfusion. Clin Cancer Res 11:7851\u20137860. doi:\n                        10.1158\/1078-0432.ccr-05-0262","journal-title":"Clin Cancer Res"},{"key":"2648_CR68","doi-asserted-by":"publisher","first-page":"143","DOI":"10.2332\/allergolint.13-RAI-0663","volume":"63","author":"K Izuhara","year":"2014","unstructured":"Izuhara K, Arima K, Ohta S, Suzuki S, Inamitsu M, Yamamoto K (2014) Periostin in allergic inflammation. Allergol Int 63:143\u2013151. doi:\n                        10.2332\/allergolint.13-RAI-0663","journal-title":"Allergol Int"}],"container-title":["Cellular and Molecular Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00018-017-2648-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-017-2648-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-017-2648-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,10,26]],"date-time":"2017-10-26T04:31:03Z","timestamp":1508992263000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00018-017-2648-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,8]]},"references-count":68,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["2648"],"URL":"https:\/\/doi.org\/10.1007\/s00018-017-2648-0","relation":{},"ISSN":["1420-682X","1420-9071"],"issn-type":[{"value":"1420-682X","type":"print"},{"value":"1420-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,8]]}}}