{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T23:55:39Z","timestamp":1790639739985,"version":"4.1.0"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2017,10,3]],"date-time":"2017-10-03T00:00:00Z","timestamp":1506988800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100011264","name":"FP7 People: Marie-Curie Actions","doi-asserted-by":"publisher","award":["320553"],"award-info":[{"award-number":["320553"]}],"id":[{"id":"10.13039\/100011264","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell. Mol. Life Sci."],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1007\/s00018-017-2667-x","type":"journal-article","created":{"date-parts":[[2017,10,4]],"date-time":"2017-10-04T03:10:31Z","timestamp":1507086631000},"page":"905-919","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["The impact of thyroid hormone in seasonal breeding has a restricted transcriptional signature"],"prefix":"10.1007","volume":"75","author":[{"given":"Didier","family":"Lomet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliette","family":"Cogni\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Chesneau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emeric","family":"Dubois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Hazlerigg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7209-5940","authenticated-orcid":false,"given":"Hugues","family":"Dardente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,10,3]]},"reference":[{"key":"2667_CR1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3389\/fendo.2014.00019","volume":"5","author":"H Dardente","year":"2014","unstructured":"Dardente H, Hazlerigg DG, Ebling FJ (2014) Thyroid hormone and seasonal rhythmicity. Front Endocrinol (Lausanne) 5:19","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2667_CR2","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3389\/fendo.2014.00012","volume":"5","author":"A Shinomiya","year":"2014","unstructured":"Shinomiya A, Shimmura T, Nishiwaki-Ohkawa T, Yoshimura T (2014) Regulation of seasonal reproduction by hypothalamic activation of thyroid hormone. Front Endocrinol (Lausanne) 5:12","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2667_CR3","doi-asserted-by":"crossref","first-page":"R39","DOI":"10.1530\/JOE-14-0141","volume":"222","author":"S Wood","year":"2014","unstructured":"Wood S, Loudon A (2014) Clocks for all seasons: unwinding the roles and mechanisms of circadian and interval timers in the hypothalamus and pituitary. J Endocrinol 222:R39\u2013R59","journal-title":"J Endocrinol"},{"key":"2667_CR4","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1126\/science.1132009","volume":"314","author":"GA Lincoln","year":"2006","unstructured":"Lincoln GA, Clarke IJ, Hut RA, Hazlerigg DG (2006) Characterizing a mammalian circannual pacemaker. Science 314:1941\u20131944","journal-title":"Science"},{"key":"2667_CR5","doi-asserted-by":"crossref","first-page":"e62003","DOI":"10.1371\/journal.pone.0062003","volume":"8","author":"A Herwig","year":"2013","unstructured":"Herwig A, de Vries EM, Bolborea M, Wilson D, Mercer JG, Ebling FJ, Morgan PJ, Barrett P (2013) Hypothalamic ventricular ependymal thyroid hormone deiodinases are an important element of circannual timing in the Siberian hamster (Phodopus sungorus). PLoS One 8:e62003","journal-title":"PLoS One"},{"key":"2667_CR6","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/jne.12013","volume":"25","author":"C Saenz de Miera","year":"2013","unstructured":"Saenz de Miera C, Hanon EA, Dardente H, Birnie M, Simonneaux V, Lincoln GA, Hazlerigg DG (2013) Circannual variation in thyroid hormone deiodinases in a short-day breeder. J Neuroendocrinol 25:412\u2013421","journal-title":"J Neuroendocrinol"},{"key":"2667_CR7","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1016\/j.cub.2014.05.024","volume":"24","author":"C Saenz de Miera","year":"2014","unstructured":"Saenz de Miera C, Monecke S, Bartzen-Sprauer J, Laran-Chich MP, Pevet P, Hazlerigg DG, Simonneaux V (2014) A circannual clock drives expression of genes central for seasonal reproduction. Curr Biol 24:1500\u20131506","journal-title":"Curr Biol"},{"key":"2667_CR8","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1016\/j.cub.2015.09.014","volume":"25","author":"SH Wood","year":"2015","unstructured":"Wood SH, Christian HC, Miedzinska K, Saer BR, Johnson M, Paton B, Yu L, McNeilly J, Davis JR, McNeilly AS, Burt DW, Loudon AS (2015) Binary switching of calendar cells in the pituitary defines the phase of the circannual cycle in mammals. Curr Biol 25:2651\u20132662","journal-title":"Curr Biol"},{"key":"2667_CR9","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.cub.2010.02.066","volume":"20","author":"SM Dupre","year":"2010","unstructured":"Dupre SM, Miedzinska K, Duval CV, Yu L, Goodman RL, Lincoln GA, Davis JR, McNeilly AS, Burt DW, Loudon AS (2010) Identification of Eya3 and TAC1 as long-day signals in the sheep pituitary. Curr Biol 20:829\u2013835","journal-title":"Curr Biol"},{"key":"2667_CR10","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1016\/j.cub.2010.10.048","volume":"20","author":"H Dardente","year":"2010","unstructured":"Dardente H, Wyse CA, Birnie MJ, Dupre SM, Loudon AS, Lincoln GA, Hazlerigg DG (2010) A molecular switch for photoperiod responsiveness in mammals. Curr Biol 20:2193\u20132198","journal-title":"Curr Biol"},{"key":"2667_CR11","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1016\/j.cub.2010.11.038","volume":"20","author":"KH Masumoto","year":"2010","unstructured":"Masumoto KH, Ukai-Tadenuma M, Kasukawa T, Nagano M, Uno KD, Tsujino K, Horikawa K, Shigeyoshi Y, Ueda HR (2010) Acute induction of Eya3 by late-night light stimulation triggers TSHbeta expression in photoperiodism. Curr Biol 20:2199\u20132206","journal-title":"Curr Biol"},{"key":"2667_CR12","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1089\/thy.2005.15.883","volume":"15","author":"RM Lechan","year":"2005","unstructured":"Lechan RM, Fekete C (2005) Role of thyroid hormone deiodination in the hypothalamus. Thyroid 15:883\u2013897","journal-title":"Thyroid"},{"key":"2667_CR13","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/j.cub.2008.06.076","volume":"18","author":"EA Hanon","year":"2008","unstructured":"Hanon EA, Lincoln GA, Fustin JM, Dardente H, Masson-Pevet M, Morgan PJ, Hazlerigg DG (2008) Ancestral TSH mechanism signals summer in a photoperiodic mammal. Curr Biol 18:1147\u20131152","journal-title":"Curr Biol"},{"key":"2667_CR14","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1051\/rnd:19880304","volume":"28","author":"TJ Nicholls","year":"1988","unstructured":"Nicholls TJ, Follett BK, Goldsmith AR, Pearson H (1988) Possible homologies between photorefractoriness in sheep and birds: the effect of thyroidectomy on the length of the ewe\u2019s breeding season. Reprod Nutr Dev 28:375\u2013385","journal-title":"Reprod Nutr Dev"},{"key":"2667_CR15","doi-asserted-by":"crossref","first-page":"3605","DOI":"10.1210\/en.2007-0596","volume":"148","author":"DA Bechtold","year":"2007","unstructured":"Bechtold DA, Loudon AS (2007) Hypothalamic thyroid hormones: mediators of seasonal physiology. Endocrinology 148:3605\u20133607","journal-title":"Endocrinology"},{"key":"2667_CR16","first-page":"185","volume":"40","author":"FJ Karsch","year":"1984","unstructured":"Karsch FJ, Bittman EL, Foster DL, Goodman RL, Legan SJ, Robinson JE (1984) Neuroendocrine basis of seasonal reproduction. Recent Prog Horm Res 40:185\u2013232","journal-title":"Recent Prog Horm Res"},{"key":"2667_CR17","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1365-2826.2011.02250.x","volume":"24","author":"H Dardente","year":"2012","unstructured":"Dardente H (2012) Melatonin-dependent timing of seasonal reproduction by the pars tuberalis: pivotal roles for long day lengths and thyroid hormones. J Neuroendocrinol 24:249\u2013266","journal-title":"J Neuroendocrinol"},{"key":"2667_CR18","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1210\/endo-128-3-1337","volume":"128","author":"SM Moenter","year":"1991","unstructured":"Moenter SM, Woodfill CJ, Karsch FJ (1991) Role of the thyroid gland in seasonal reproduction: thyroidectomy blocks seasonal suppression of reproductive neuroendocrine activity in ewes. Endocrinology 128:1337\u20131344","journal-title":"Endocrinology"},{"key":"2667_CR19","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1210\/endo.143.7.8924","volume":"143","author":"HJ Billings","year":"2002","unstructured":"Billings HJ, Viguie C, Karsch FJ, Goodman RL, Connors JM, Anderson GM (2002) Temporal requirements of thyroid hormones for seasonal changes in LH secretion. Endocrinology 143:2618\u20132625","journal-title":"Endocrinology"},{"key":"2667_CR20","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nature06738","volume":"452","author":"N Nakao","year":"2008","unstructured":"Nakao N, Ono H, Yamamura T, Anraku T, Takagi T, Higashi K, Yasuo S, Katou Y, Kageyama S, Uno Y, Kasukawa T, Iigo M, Sharp PJ, Iwasawa A, Suzuki Y, Sugano S, Niimi T, Mizutani M, Namikawa T, Ebihara S, Ueda HR, Yoshimura T (2008) Thyrotrophin in the pars tuberalis triggers photoperiodic response. Nature 452:317\u2013322","journal-title":"Nature"},{"key":"2667_CR21","doi-asserted-by":"crossref","first-page":"5527","DOI":"10.1210\/en.2008-0834","volume":"149","author":"SM Dupre","year":"2008","unstructured":"Dupre SM, Burt DW, Talbot R, Downing A, Mouzaki D, Waddington D, Malpaux B, Davis JR, Lincoln GA, Loudon AS (2008) Identification of melatonin-regulated genes in the ovine pituitary pars tuberalis, a target site for seasonal hormone control. Endocrinology 149:5527\u20135539","journal-title":"Endocrinology"},{"key":"2667_CR22","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1177\/002215540205001209","volume":"50","author":"P Klosen","year":"2002","unstructured":"Klosen P, Bienvenu C, Demarteau O, Dardente H, Guerrero H, Pevet P, Masson-Pevet M (2002) The mt1 melatonin receptor and RORbeta receptor are co-localized in specific TSH-immunoreactive cells in the pars tuberalis of the rat pituitary. J Histochem Cytochem 50:1647\u20131657","journal-title":"J Histochem Cytochem"},{"key":"2667_CR23","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3389\/fendo.2016.00036","volume":"7","author":"JB Henningsen","year":"2016","unstructured":"Henningsen JB, Gauer F, Simonneaux V (2016) RFRP neurons\u2014the doorway to understanding seasonal reproduction in mammals. Front Endocrinol (Lausanne) 7:36","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2667_CR24","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.bbagrm.2014.05.023","volume":"1849","author":"F Chatonnet","year":"2015","unstructured":"Chatonnet F, Flamant F, Morte B (2015) A temporary compendium of thyroid hormone target genes in brain. Biochim Biophys Acta 1849:122\u2013129","journal-title":"Biochim Biophys Acta"},{"key":"2667_CR25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1210\/me.2010-0095","volume":"25","author":"WE Visser","year":"2011","unstructured":"Visser WE, Friesema EC, Visser TJ (2011) Minireview: thyroid hormone transporters: the knowns and the unknowns. Mol Endocrinol 25:1\u201314","journal-title":"Mol Endocrinol"},{"key":"2667_CR26","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0074-7696(05)47003-5","volume":"247","author":"EM Rodriguez","year":"2005","unstructured":"Rodriguez EM, Blazquez JL, Pastor FE, Pelaez B, Pena P, Peruzzo B, Amat P (2005) Hypothalamic tanycytes: a key component of brain-endocrine interaction. Int Rev Cytol 247:89\u2013164","journal-title":"Int Rev Cytol"},{"key":"2667_CR27","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1530\/jrf.0.1010051","volume":"101","author":"TJ Parkinson","year":"1994","unstructured":"Parkinson TJ, Follett BK (1994) Effect of thyroidectomy upon seasonality in rams. J Reprod Fertil 101:51\u201358","journal-title":"J Reprod Fertil"},{"key":"2667_CR28","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1007\/s00018-007-7396-0","volume":"65","author":"B Gereben","year":"2008","unstructured":"Gereben B, Zeold A, Dentice M, Salvatore D, Bianco AC (2008) Activation and inactivation of thyroid hormone by deiodinases: local action with general consequences. Cell Mol Life Sci 65:570\u2013590","journal-title":"Cell Mol Life Sci"},{"key":"2667_CR29","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1210\/endo-129-1-176","volume":"129","author":"JR Webster","year":"1991","unstructured":"Webster JR, Moenter SM, Woodfill CJ, Karsch FJ (1991) Role of the thyroid gland in seasonal reproduction. II. thyroxine allows a season-specific suppression of gonadotropin secretion in sheep. Endocrinology 129:176\u2013183","journal-title":"Endocrinology"},{"key":"2667_CR30","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1152\/physrev.00030.2013","volume":"94","author":"R Mullur","year":"2014","unstructured":"Mullur R, Liu YY, Brent GA (2014) Thyroid hormone regulation of metabolism. Physiol Rev 94:355\u2013382","journal-title":"Physiol Rev"},{"key":"2667_CR31","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/0007-1935(84)90038-1","volume":"140","author":"PJ Pijoan","year":"1984","unstructured":"Pijoan PJ, Williams HL (1984) Effects of shearing on the reproductive activity and plasma prolactin levels of Dorset ewes. Br Vet J 140:444\u2013449","journal-title":"Br Vet J"},{"key":"2667_CR32","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1530\/acta.0.0830720","volume":"83","author":"JP Ravault","year":"1976","unstructured":"Ravault JP (1976) Prolactin in the ram: seasonal variations in the concentration of blood plasma from birth until three years old. Acta Endocrinol (Copenh) 83:720\u2013725","journal-title":"Acta Endocrinol (Copenh)"},{"key":"2667_CR33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1071\/RD9920001","volume":"4","author":"JD Curlewis","year":"1992","unstructured":"Curlewis JD (1992) Seasonal prolactin secretion and its role in seasonal reproduction: a review. Reprod Fertil Dev 4:1\u201323","journal-title":"Reprod Fertil Dev"},{"key":"2667_CR34","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1210\/edrv.22.6.0451","volume":"22","author":"N Ben-Jonathan","year":"2001","unstructured":"Ben-Jonathan N, Hnasko R (2001) Dopamine as a prolactin (PRL) inhibitor. Endocr Rev 22:724\u2013763","journal-title":"Endocr Rev"},{"key":"2667_CR35","doi-asserted-by":"crossref","first-page":"3608","DOI":"10.1210\/en.2007-0316","volume":"148","author":"P Barrett","year":"2007","unstructured":"Barrett P, Ebling FJ, Schuhler S, Wilson D, Ross AW, Warner A, Jethwa P, Boelen A, Visser TJ, Ozanne DM, Archer ZA, Mercer JG, Morgan PJ (2007) Hypothalamic thyroid hormone catabolism acts as a gatekeeper for the seasonal control of body weight and reproduction. Endocrinology 148:3608\u20133617","journal-title":"Endocrinology"},{"key":"2667_CR36","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1210\/en.2011-1249","volume":"153","author":"M Murphy","year":"2012","unstructured":"Murphy M, Jethwa PH, Warner A, Barrett P, Nilaweera KN, Brameld JM, Ebling FJ (2012) Effects of manipulating hypothalamic triiodothyronine concentrations on seasonal body weight and torpor cycles in Siberian hamsters. Endocrinology 153:101\u2013112","journal-title":"Endocrinology"},{"key":"2667_CR37","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1046\/j.1365-2826.2003.01060.x","volume":"15","author":"H Dardente","year":"2003","unstructured":"Dardente H, Klosen P, Pevet P, Masson-Pevet M (2003) MT1 melatonin receptor mRNA expressing cells in the pars tuberalis of the European hamster: effect of photoperiod. J Neuroendocrinol 15:778\u2013786","journal-title":"J Neuroendocrinol"},{"key":"2667_CR38","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1210\/endo.138.3.5007","volume":"138","author":"J Bockmann","year":"1997","unstructured":"Bockmann J, Bo Ckers TM, Winter C, Wittkowski W, Winterhoff H, Deufel T, Kreutz MR (1997) Thyrotropin expression in hypophyseal pars tuberalis-specific cells is 3,5,3\u2032-triiodothyronine, thyrotropin-releasing hormone, and Pit-1 independent. Endocrinology 138:1019\u20131028","journal-title":"Endocrinology"},{"key":"2667_CR39","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.celrep.2014.10.006","volume":"9","author":"K Ikegami","year":"2014","unstructured":"Ikegami K, Liao XH, Hoshino Y, Ono H, Ota W, Ito Y, Nishiwaki-Ohkawa T, Sato C, Kitajima K, Iigo M, Shigeyoshi Y, Yamada M, Murata Y, Refetoff S, Yoshimura T (2014) Tissue-specific posttranslational modification allows functional targeting of thyrotropin. Cell Rep 9:801\u2013810","journal-title":"Cell Rep"},{"key":"2667_CR40","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nrendo.2015.205","volume":"12","author":"PJ Davis","year":"2016","unstructured":"Davis PJ, Goglia F, Leonard JL (2016) Nongenomic actions of thyroid hormone. Nat Rev Endocrinol 12:111\u2013121","journal-title":"Nat Rev Endocrinol"},{"key":"2667_CR41","doi-asserted-by":"crossref","first-page":"15862","DOI":"10.1073\/pnas.1520099112","volume":"112","author":"AV Reshetnyak","year":"2015","unstructured":"Reshetnyak AV, Murray PB, Shi X, Mo ES, Mohanty J, Tome F, Bai H, Gunel M, Lax I, Schlessinger J (2015) Augmentor alpha and beta (FAM150) are ligands of the receptor tyrosine kinases ALK and LTK: hierarchy and specificity of ligand-receptor interactions. Proc Natl Acad Sci USA 112:15862\u201315867","journal-title":"Proc Natl Acad Sci USA"},{"key":"2667_CR42","doi-asserted-by":"crossref","first-page":"e09811","DOI":"10.7554\/eLife.09811","volume":"4","author":"J Guan","year":"2015","unstructured":"Guan J, Umapathy G, Yamazaki Y, Wolfstetter G, Mendoza P, Pfeifer K, Mohammed A, Hugosson F, Zhang H, Hsu AW, Halenbeck R, Hallberg B, Palmer RH (2015) FAM150A and FAM150B are activating ligands for anaplastic lymphoma kinase. Elife 4:e09811","journal-title":"Elife"},{"key":"2667_CR43","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.jprot.2014.07.024","volume":"112","author":"V Labas","year":"2015","unstructured":"Labas V, Grasseau I, Cahier K, Gargaros A, Harichaux G, Teixeira-Gomes AP, Alves S, Bourin M, Gerard N, Blesbois E (2015) Qualitative and quantitative peptidomic and proteomic approaches to phenotyping chicken semen. J Proteomics 112:313\u2013335","journal-title":"J Proteomics"},{"key":"2667_CR44","first-page":"323","volume":"17","author":"Z Chen","year":"2011","unstructured":"Chen Z, Shamsi FA, Li K, Huang Q, Al-Rajhi AA, Chaudhry IA, Wu K (2011) Comparison of camel tear proteins between summer and winter. Mol Vis 17:323\u2013331","journal-title":"Mol Vis"},{"key":"2667_CR45","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.semcdb.2014.01.005","volume":"28","author":"C Berasain","year":"2014","unstructured":"Berasain C, Avila MA (2014) Amphiregulin. Semin Cell Dev Biol 28:31\u201341","journal-title":"Semin Cell Dev Biol"},{"key":"2667_CR46","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1111\/j.1365-2826.2007.01564.x","volume":"19","author":"H Dardente","year":"2007","unstructured":"Dardente H (2007) Does a melatonin-dependent circadian oscillator in the pars tuberalis drive prolactin seasonal rhythmicity? J Neuroendocrinol 19:657\u2013666","journal-title":"J Neuroendocrinol"},{"key":"2667_CR47","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1002\/cne.22606","volume":"519","author":"SD Clark","year":"2011","unstructured":"Clark SD, Duangdao DM, Schulz S, Zhang L, Liu X, Xu YL, Reinscheid RK (2011) Anatomical characterization of the neuropeptide S system in the mouse brain by in situ hybridization and immunohistochemistry. J Comp Neurol 519:1867\u20131893","journal-title":"J Comp Neurol"},{"key":"2667_CR48","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s00428-014-1602-x","volume":"465","author":"V Pulkkinen","year":"2014","unstructured":"Pulkkinen V, Ezer S, Sundman L, Hagstrom J, Remes S, Soderhall C, Greco D, Haglund C, Kere J, Arola J (2014) Neuropeptide S receptor 1 (NPSR1) activates cancer-related pathways and is widely expressed in neuroendocrine tumors. Virchows Arch 465:173\u2013183","journal-title":"Virchows Arch"},{"key":"2667_CR49","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1101\/gad.938601","volume":"15","author":"PW Ingham","year":"2001","unstructured":"Ingham PW, McMahon AP (2001) Hedgehog signaling in animal development: paradigms and principles. Genes Dev 15:3059\u20133087","journal-title":"Genes Dev"},{"key":"2667_CR50","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.tins.2012.12.008","volume":"36","author":"M Bolborea","year":"2013","unstructured":"Bolborea M, Dale N (2013) Hypothalamic tanycytes: potential roles in the control of feeding and energy balance. Trends Neurosci 36:91\u2013100","journal-title":"Trends Neurosci"},{"key":"2667_CR51","doi-asserted-by":"crossref","first-page":"387","DOI":"10.3389\/fnins.2015.00387","volume":"9","author":"T Goodman","year":"2015","unstructured":"Goodman T, Hajihosseini MK (2015) Hypothalamic tanycytes-masters and servants of metabolic, neuroendocrine, and neurogenic functions. Front Neurosci 9:387","journal-title":"Front Neurosci"},{"key":"2667_CR52","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.semcdb.2014.05.008","volume":"33","author":"A Alvarez-Buylla","year":"2014","unstructured":"Alvarez-Buylla A, Ihrie RA (2014) Sonic hedgehog signaling in the postnatal brain. Semin Cell Dev Biol 33:105\u2013111","journal-title":"Semin Cell Dev Biol"},{"key":"2667_CR53","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1177\/0748730411420812","volume":"26","author":"DG Hazlerigg","year":"2011","unstructured":"Hazlerigg DG, Lincoln GA (2011) Hypothesis: cyclical histogenesis is the basis of circannual timing. J Biol Rhythms 26:471\u2013485","journal-title":"J Biol Rhythms"},{"key":"2667_CR54","doi-asserted-by":"crossref","first-page":"548","DOI":"10.3109\/07420528.2012.754450","volume":"30","author":"DG Hazlerigg","year":"2013","unstructured":"Hazlerigg DG, Wyse CA, Dardente H, Hanon EA, Lincoln GA (2013) Photoperiodic variation in CD45-positive cells and cell proliferation in the mediobasal hypothalamus of the Soay sheep. Chronobiol Int 30:548\u2013558","journal-title":"Chronobiol Int"},{"key":"2667_CR55","doi-asserted-by":"crossref","first-page":"3301","DOI":"10.1007\/s00429-015-1101-0","volume":"221","author":"M Batailler","year":"2016","unstructured":"Batailler M, Derouet L, Butruille L, Migaud M (2016) Sensitivity to the photoperiod and potential migratory features of neuroblasts in the adult sheep hypothalamus. Brain Struct Funct 221:3301\u20133314","journal-title":"Brain Struct Funct"},{"key":"2667_CR56","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.tem.2013.10.005","volume":"25","author":"L Sousa-Ferreira","year":"2014","unstructured":"Sousa-Ferreira L, de Almeida LP, Cavadas C (2014) Role of hypothalamic neurogenesis in feeding regulation. Trends Endocrinol Metab 25:80\u201388","journal-title":"Trends Endocrinol Metab"},{"key":"2667_CR57","doi-asserted-by":"crossref","first-page":"62","DOI":"10.3389\/fendo.2014.00062","volume":"5","author":"S Remaud","year":"2014","unstructured":"Remaud S, Gothie JD, Morvan-Dubois G, Demeneix BA (2014) Thyroid hormone signaling and adult neurogenesis in mammals. Front Endocrinol (Lausanne) 5:62","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2667_CR58","doi-asserted-by":"crossref","first-page":"14466","DOI":"10.1073\/pnas.0706754104","volume":"104","author":"M Dentice","year":"2007","unstructured":"Dentice M, Luongo C, Huang S, Ambrosio R, Elefante A, Mirebeau-Prunier D, Zavacki AM, Fenzi G, Grachtchouk M, Hutchin M, Dlugosz AA, Bianco AC, Missero C, Larsen PR, Salvatore D (2007) Sonic hedgehog-induced type 3 deiodinase blocks thyroid hormone action enhancing proliferation of normal and malignant keratinocytes. Proc Natl Acad Sci USA 104:14466\u201314471","journal-title":"Proc Natl Acad Sci USA"},{"key":"2667_CR59","doi-asserted-by":"crossref","first-page":"14","DOI":"10.12703\/P7-14","volume":"7","author":"S Wilkens","year":"2015","unstructured":"Wilkens S (2015) Structure and mechanism of ABC transporters. F1000Prime Rep 7:14 (eCollection 2015)","journal-title":"F1000Prime Rep"},{"key":"2667_CR60","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.3390\/molecules19022299","volume":"19","author":"F Bellia","year":"2014","unstructured":"Bellia F, Vecchio G, Rizzarelli E (2014) Carnosinases, their substrates and diseases. Molecules 19:2299\u20132329","journal-title":"Molecules"},{"key":"2667_CR61","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0301-0082(99)00010-6","volume":"59","author":"L Bonfanti","year":"1999","unstructured":"Bonfanti L, Peretto P, De Marchis S, Fasolo A (1999) Carnosine-related dipeptides in the mammalian brain. Prog Neurobiol 59:333\u2013353","journal-title":"Prog Neurobiol"},{"key":"2667_CR62","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/j.1471-4159.2004.02869.x","volume":"92","author":"D Amparan","year":"2005","unstructured":"Amparan D, Avram D, Thomas CG, Lindahl MG, Yang J, Bajaj G, Ishmael JE (2005) Direct interaction of myosin regulatory light chain with the NMDA receptor. J Neurochem 92:349\u2013361","journal-title":"J Neurochem"},{"key":"2667_CR63","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s00441-005-0126-8","volume":"324","author":"T Yamamura","year":"2006","unstructured":"Yamamura T, Yasuo S, Hirunagi K, Ebihara S, Yoshimura T (2006) T(3) implantation mimics photoperiodically reduced encasement of nerve terminals by glial processes in the median eminence of Japanese quail. Cell Tissue Res 324:175\u2013179","journal-title":"Cell Tissue Res"},{"key":"2667_CR64","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1096\/fj.13-229559","volume":"27","author":"P Klosen","year":"2013","unstructured":"Klosen P, Sebert ME, Rasri K, Laran-Chich MP, Simonneaux V (2013) TSH restores a summer phenotype in photoinhibited mammals via the RF-amides RFRP3 and kisspeptin. FASEB J 27:2677\u20132686","journal-title":"FASEB J"},{"key":"2667_CR65","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1111\/j.1365-2826.2008.01784.x","volume":"20","author":"H Dardente","year":"2008","unstructured":"Dardente H, Birnie M, Lincoln GA, Hazlerigg DG (2008) RFamide-related peptide and its cognate receptor in the sheep: cDNA cloning, mRNA distribution in the hypothalamus and the effect of photoperiod. J Neuroendocrinol 20:1252\u20131259","journal-title":"J Neuroendocrinol"},{"key":"2667_CR66","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1210\/en.2007-0848","volume":"149","author":"FG Revel","year":"2008","unstructured":"Revel FG, Saboureau M, Pevet P, Simonneaux V, Mikkelsen JD (2008) RFamide-related peptide gene is a melatonin-driven photoperiodic gene. Endocrinology 149:902\u2013912","journal-title":"Endocrinology"},{"key":"2667_CR67","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.domaniend.2011.11.003","volume":"43","author":"JT Smith","year":"2012","unstructured":"Smith JT (2012) The role of kisspeptin and gonadotropin inhibitory hormone in the seasonal regulation of reproduction in sheep. Domest Anim Endocrinol 43:75\u201384","journal-title":"Domest Anim Endocrinol"},{"key":"2667_CR68","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1210\/en.2015-1854","volume":"157","author":"C Decourt","year":"2016","unstructured":"Decourt C, Anger K, Robert V, Lomet D, Bartzen-Sprauer J, Caraty A, Dufourny L, Anderson G, Beltramo M (2016) No evidence that RFamide-related peptide 3 directly modulates LH secretion in the Ewe. Endocrinology 157:1566\u20131575","journal-title":"Endocrinology"}],"container-title":["Cellular and Molecular Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00018-017-2667-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-017-2667-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-017-2667-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,4]],"date-time":"2019-10-04T02:32:44Z","timestamp":1570156364000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00018-017-2667-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,3]]},"references-count":68,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["2667"],"URL":"https:\/\/doi.org\/10.1007\/s00018-017-2667-x","relation":{},"ISSN":["1420-682X","1420-9071"],"issn-type":[{"value":"1420-682X","type":"print"},{"value":"1420-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,3]]}}}