{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T11:50:04Z","timestamp":1773661804491,"version":"3.50.1"},"reference-count":112,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2017,11,28]],"date-time":"2017-11-28T00:00:00Z","timestamp":1511827200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell. Mol. Life Sci."],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1007\/s00018-017-2718-3","type":"journal-article","created":{"date-parts":[[2017,11,28]],"date-time":"2017-11-28T14:21:12Z","timestamp":1511878872000},"page":"1889-1907","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["D2A sequence of the urokinase receptor induces cell growth through \u03b1v\u03b23 integrin and EGFR"],"prefix":"10.1007","volume":"75","author":[{"given":"Gabriele","family":"Eden","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Archinti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralitsa","family":"Arnaudova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppina","family":"Andreotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Motta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Furlan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Citro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Vittoria","family":"Cubellis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6807-3834","authenticated-orcid":false,"given":"Bernard","family":"Degryse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,11,28]]},"reference":[{"key":"2718_CR1","doi-asserted-by":"publisher","first-page":"1923","DOI":"10.1016\/j.febslet.2009.12.039","volume":"584","author":"F Blasi","year":"2009","unstructured":"Blasi F, Sidenius N (2009) The urokinase receptor: focused cell surface proteolysis, cell adhesion and signaling. FEBS Lett 584:1923\u20131930. https:\/\/doi.org\/10.1016\/j.febslet.2009.12.039","journal-title":"FEBS Lett"},{"key":"2718_CR2","doi-asserted-by":"crossref","first-page":"271","DOI":"10.2174\/187152711794480393","volume":"10","author":"M Archinti","year":"2011","unstructured":"Archinti M, Britto M, Eden G, Furlan F, Murphy R, Degryse B (2011) The urokinase receptor in the central nervous system. CNS Neurol Disord Drug Targets 10:271\u2013294","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"2718_CR3","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.2174\/138161211796718189","volume":"17","author":"M Rosso Del","year":"2011","unstructured":"Del Rosso M, Margheri F, Serrat\u00ec S, Chill\u00e0 A, Laurenzana A, Fibbi G (2011) The urokinase receptor system, a key regulator at the intersection between inflammation, immunity, and coagulation. Curr Pharm Des 17:1924\u20131943","journal-title":"Curr Pharm Des"},{"key":"2718_CR4","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.2174\/138161211796718215","volume":"17","author":"G Eden","year":"2011","unstructured":"Eden G, Archinti M, Furlan F, Murphy R, Degryse B (2011) The urokinase receptor interactome. Curr Pharm Des 17:1874\u20131889","journal-title":"Curr Pharm Des"},{"key":"2718_CR5","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1159\/000353310","volume":"99","author":"N Montuori","year":"2014","unstructured":"Montuori N, Ragno P (2014) Role of uPA\/uPAR in the modulation of angiogenesis. Chem Immunol Allergy 99:105\u2013122","journal-title":"Chem Immunol Allergy"},{"key":"2718_CR6","doi-asserted-by":"publisher","first-page":"154","DOI":"10.3389\/fphar.2015.00154","volume":"6","author":"SL Gonias","year":"2015","unstructured":"Gonias SL, Hu J (2015) Urokinase receptor and resistance to targeted anticancer agents. Front Pharmacol 6:154. https:\/\/doi.org\/10.3389\/fphar.2015.00154","journal-title":"Front Pharmacol"},{"key":"2718_CR7","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.biocel.2017.04.012","volume":"88","author":"B Degryse","year":"2017","unstructured":"Degryse B, Britto M, Shan CX, Wallace RG, Rochfort KD, Cummins PM, Meade G, Murphy RP (2017) Moesin and merlin regulate urokinase receptor-dependent endothelial cell migration, adhesion and angiogenesis. Int J Biochem Cell Biol 88:14\u201322. https:\/\/doi.org\/10.1016\/j.biocel.2017.04.012","journal-title":"Int J Biochem Cell Biol"},{"key":"2718_CR8","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/978-0-387-69057-5_23","volume-title":"The cancer degradome\u2014proteases and cancer biology","author":"B Degryse","year":"2008","unstructured":"Degryse B (2008) The urokinase receptor (uPAR) and integrins constitute a cell migration signalosome. In: Edwards D, Hoyer-Hansen G, Blasi F, Sloane BF (eds) The cancer degradome\u2014proteases and cancer biology. Springer, New York, pp 451\u2013474"},{"key":"2718_CR9","first-page":"1","volume-title":"Cytoskeleton: cell movement, cytokinesis and organelles organization","author":"M Archinti","year":"2010","unstructured":"Archinti M, Eden G, Murphy R, Degryse B (2010) Follow the leader: when the urokinase receptor coordinates cell adhesion, motility and proliferation with cytoskeleton organization. In: Lansing S, Rousseau T (eds) Cytoskeleton: cell movement, cytokinesis and organelles organization. Nova Publishers, New York, pp 1\u201336"},{"key":"2718_CR10","first-page":"1","volume-title":"Chemotaxis: types, clinical significance, and mathematical models","author":"G Eden","year":"2011","unstructured":"Eden G, Archinti M, Furlan F, Fitzpatrick P, Murphy R, Degryse B (2011) The cell migration signalosome. In: Williams TC (ed) Chemotaxis: types, clinical significance, and mathematical models. Nova Publishers, New York, pp 1\u201352"},{"key":"2718_CR11","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1038\/sj.emboj.7600635","volume":"24","author":"P Llinas","year":"2005","unstructured":"Llinas P, Le Du MH, G\u00e5rdsvoll H, Dan\u00f8 K, Ploug M, Gilquin B, Stura EA, M\u00e9nez A (2005) Crystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptide. EMBO J 24:1655\u20131663","journal-title":"EMBO J"},{"key":"2718_CR12","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1107\/S0907444905014174","volume":"61","author":"M Huang","year":"2005","unstructured":"Huang M, Mazar AP, Parry G, Higazi AA, Kuo A, Cines DB (2005) Crystallization of soluble urokinase receptor (suPAR) in complex with urokinase amino-terminal fragment (1\u2013143). Acta Crystallogr D Biol Crystallogr 61:697\u2013700","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"2718_CR13","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.jmb.2006.08.063","volume":"363","author":"C Barinka","year":"2006","unstructured":"Barinka C, Parry G, Callahan J, Shaw DE, Kuo A, Bdeir K, Cines DB, Mazar A, Lubkowski J (2006) Structural basis of interaction between urokinase-type plasminogen activator and its receptor. J Mol Biol 363:482\u2013495","journal-title":"J Mol Biol"},{"key":"2718_CR14","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1038\/nsmb.1404","volume":"15","author":"Q Huai","year":"2008","unstructured":"Huai Q, Zhou A, Lin L, Mazar AP, Parry GC, Callahan J, Shaw DE, Furie B, Furie BC, Huang M (2008) Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes. Nat Struct Mol Biol 15:422\u2013423. https:\/\/doi.org\/10.1038\/nsmb.1404","journal-title":"Nat Struct Mol Biol"},{"key":"2718_CR15","doi-asserted-by":"crossref","first-page":"24792","DOI":"10.1074\/jbc.M413954200","volume":"280","author":"B Degryse","year":"2005","unstructured":"Degryse B, Resnati M, Czekay RP, Loskutoff DJ, Blasi F (2005) Domain 2 of the urokinase receptor contains an integrin-interacting epitope with intrinsic signaling activity: generation of a new integrin inhibitor. J Biol Chem 280:24792\u201324803","journal-title":"J Biol Chem"},{"key":"2718_CR16","doi-asserted-by":"crossref","first-page":"14852","DOI":"10.1074\/jbc.M512311200","volume":"281","author":"P Chaurasia","year":"2006","unstructured":"Chaurasia P, Aguirre-Ghiso JA, Liang OD, Gardsvoll H, Ploug M, Ossowski L (2006) A region in urokinase plasminogen receptor domain III controlling a functional association with alpha5beta1 integrin and tumor growth. J Biol Chem 281:14852\u201314863","journal-title":"J Biol Chem"},{"key":"2718_CR17","doi-asserted-by":"crossref","first-page":"3929","DOI":"10.1074\/jbc.M607989200","volume":"282","author":"Y Wei","year":"2007","unstructured":"Wei Y, Tang CH, Kim Y, Robillard L, Zhang F, Kugler MC, Chapman HA (2007) Urokinase receptors are required for alpha5 beta1 integrin-mediated signaling in tumor cells. J Biol Chem 282:3929\u20133939","journal-title":"J Biol Chem"},{"key":"2718_CR18","doi-asserted-by":"publisher","first-page":"5111","DOI":"10.1182\/blood-2009-08-236430","volume":"115","author":"GA LaRusch","year":"2010","unstructured":"LaRusch GA, Mahdi F, Shariat-Madar Z, Adams G, Sitrin RG, Zhang WM, McCrae KR, Schmaier AH (2010) Factor XII stimulates ERK1\/2 and Akt through uPAR, integrins, and the EGFR to initiate angiogenesis. Blood 115:5111\u20135120. https:\/\/doi.org\/10.1182\/blood-2009-08-236430","journal-title":"Blood"},{"key":"2718_CR19","doi-asserted-by":"publisher","first-page":"H305","DOI":"10.1152\/ajpheart.00110.2013","volume":"305","author":"GA Larusch","year":"2013","unstructured":"Larusch GA, Merkulova A, Mahdi F, Shariat-Madar Z, Sitrin RG, Cines DB, Schmaier AH (2013) Domain 2 of uPAR regulates single-chain urokinase-mediated angiogenesis through \u03b21-integrin and VEGFR2. Am J Physiol Heart Circ Physiol 305:H305\u2013H320. https:\/\/doi.org\/10.1152\/ajpheart.00110.2013","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2718_CR20","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1096\/fasebj.1.2.3038646","volume":"1","author":"JC Kirchheimer","year":"1987","unstructured":"Kirchheimer JC, Wojta J, Christ G, Binder BR (1987) Proliferation of a human epidermal tumor cell line stimulated by urokinase. FASEB J 1:125\u2013128","journal-title":"FASEB J"},{"key":"2718_CR21","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/S0006-291X(05)80893-9","volume":"173","author":"SA Rabbani","year":"1990","unstructured":"Rabbani SA, Desjardins J, Bell AW, Banville D, Mazar A, Henkin J, Goltzman D (1990) An amino-terminal fragment of urokinase isolated from a prostate cancer cell line (PC-3) is mitogenic for osteoblast-like cells. Biochem Biophys Res Commun 173:1058\u20131064","journal-title":"Biochem Biophys Res Commun"},{"key":"2718_CR22","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1016\/0006-291X(91)90443-B","volume":"176","author":"CJ He","year":"1991","unstructured":"He CJ, Rebibou JM, Peraldi MN, Meulders Q, Rondeau E (1991) Growth factor-like effect of urokinase type plasminogen activator in human renal cells. Biochem Biophys Res Commun 176:1408\u20131416","journal-title":"Biochem Biophys Res Commun"},{"key":"2718_CR23","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0014-5793(98)01279-4","volume":"438","author":"K Fischer","year":"1998","unstructured":"Fischer K, Lutz V, Wilhelm O, Schmitt M, Graeff H, Heiss P, Nishiguchi T, Harbeck N, Kessler H, Luther T, Magdolen V, Reuning U (1998) Urokinase induces proliferation of human ovarian cancer cells: characterization of structural elements required for growth factor function. FEBS Lett 438:101\u2013105","journal-title":"FEBS Lett"},{"key":"2718_CR24","doi-asserted-by":"crossref","first-page":"4825","DOI":"10.1002\/j.1460-2075.1992.tb05588.x","volume":"11","author":"L Naldini","year":"1992","unstructured":"Naldini L, Tamagnone L, Vigna E, Sachs M, Hartmann G, Birchmeir W, Daikuhara Y, Tsubouchi H, Blasi F, Comoglio PM (1992) Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor\/scatter factor. EMBO J 11:4825\u20134833","journal-title":"EMBO J"},{"key":"2718_CR25","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1002\/jcp.1041580303","volume":"158","author":"LE Odekon","year":"1994","unstructured":"Odekon LE, Blasi F, Rifkin DB (1994) Requirement for receptor-bound urokinase in plasmin-dependent cellular conversion of latent TGF-beta to TGF-beta. J Cell Physiol 158:398\u2013407","journal-title":"J Cell Physiol"},{"key":"2718_CR26","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/S0955-0674(00)00140-X","volume":"12","author":"L Ossowski","year":"2000","unstructured":"Ossowski L, Aguirre-Ghiso JA (2000) Urokinase receptor and integrin partnership: coordination of signaling for cell adhesion, migration and growth. Curr Opin Cell Biol 12:613\u2013620","journal-title":"Curr Opin Cell Biol"},{"key":"2718_CR27","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1242\/jcs.114.14.2553","volume":"114","author":"MA Schwartz","year":"2001","unstructured":"Schwartz MA, Assoian RK (2001) Integrins and cell proliferation: regulation of cyclin-dependent kinases via cytoplasmic signaling pathways. J Cell Sci 114:2553\u20132560","journal-title":"J Cell Sci"},{"key":"2718_CR28","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1160\/TH05-06-0457","volume":"95","author":"T Tarui","year":"2006","unstructured":"Tarui T, Akakura N, Majumdar M, Andronicos N, Takagi J, Mazar AP, Bdeir K, Kuo A, Yarovoi SV, Cines DB, Takada Y (2006) Direct interaction of the kringle domain of urokinase-type plasminogen activator (uPA) and integrin \u03b1v\u03b23 induces signal transduction and enhances plasminogen activation. Thromb Haemost 95:524\u2013534","journal-title":"Thromb Haemost"},{"issue":"Suppl 2","key":"2718_CR29","doi-asserted-by":"publisher","first-page":"S8","DOI":"10.1186\/1471-2105-9-S2-S8","volume":"9","author":"B Degryse","year":"2008","unstructured":"Degryse B, Fernandez-Recio J, Citro V, Blasi F, Cubellis MV (2008) In silico docking of urokinase plasminogen activator and integrins. BMC Bioinform 9(Suppl 2):S8. https:\/\/doi.org\/10.1186\/1471-2105-9-S2-S8","journal-title":"BMC Bioinform"},{"key":"2718_CR30","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S1535-6108(02)00072-7","volume":"1","author":"D Liu","year":"2002","unstructured":"Liu D, Aguirre Ghiso J, Estrada Y, Ossowski L (2002) EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinoma. Cancer Cell 1:445\u2013457","journal-title":"Cancer Cell"},{"key":"2718_CR31","doi-asserted-by":"crossref","first-page":"17449","DOI":"10.1074\/jbc.M413141200","volume":"280","author":"M Jo","year":"2005","unstructured":"Jo M, Thomas KS, Marozkina N, Amin TJ, Silva CM, Parsons SJ, Gonias SL (2005) Dynamic assembly of the urokinase-type plasminogen activator signaling receptor complex determines the mitogenic activity of urokinase-type plasminogen activator. J Biol Chem 280:17449\u201317457","journal-title":"J Biol Chem"},{"key":"2718_CR32","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/sj.emboj.7600669","volume":"24","author":"J Kiyan","year":"2005","unstructured":"Kiyan J, Kiyan R, Haller H, Dumler I (2005) Urokinase-induced signaling in human vascular smooth muscle cells is mediated by PDGFR-beta. EMBO J 24:787\u20131797","journal-title":"EMBO J"},{"key":"2718_CR33","doi-asserted-by":"crossref","first-page":"4382","DOI":"10.1073\/pnas.88.10.4382","volume":"88","author":"KT Schmeidler-Sapiro","year":"1991","unstructured":"Schmeidler-Sapiro KT, Ratnoff OD, Gordon EM (1991) Mitogenic effects of coagulation factor XII and factor XIIa on HepG2 cells. Proc Natl Acad Sci USA 88:4382\u20134385","journal-title":"Proc Natl Acad Sci USA"},{"key":"2718_CR34","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1073\/pnas.93.5.2174","volume":"93","author":"EM Gordon","year":"1996","unstructured":"Gordon EM, Venkatesan N, Salazar R, Tang H, Schmeidler-Sapiro K, Buckley S, Warburton D, Hall FL (1996) Factor XII-induced mitogenesis is mediated via a distinct signal transduction pathway that activates a mitogen-activated protein kinase. Proc Natl Acad Sci USA 93:2174\u20132179","journal-title":"Proc Natl Acad Sci USA"},{"key":"2718_CR35","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1161\/01.ATV.12.10.1161","volume":"12","author":"U Reuning","year":"1992","unstructured":"Reuning U, Bang NU (1992) Regulation of the urokinase-type plasminogen activator receptor on vascular smooth muscle cells is under the control of thrombin and other mitogens. Arterioscler Thromb 12:1161\u20131170","journal-title":"Arterioscler Thromb"},{"key":"2718_CR36","doi-asserted-by":"crossref","first-page":"3700","DOI":"10.1182\/blood.V84.11.3700.bloodjournal84113700","volume":"84","author":"U Reuning","year":"1994","unstructured":"Reuning U, Little SP, Dixon EP, Bang NU (1994) Effect of thrombin, the thrombin receptor activation peptide, and other mitogens on vascular smooth muscle cell urokinase receptor mRNA levels. Blood 84:3700\u20133708","journal-title":"Blood"},{"key":"2718_CR37","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.thromres.2004.01.008","volume":"113","author":"S Ueshima","year":"2004","unstructured":"Ueshima S, Fukao H, Okada K, Matsuo O (2004) Growth inhibition of vascular smooth muscle cells derived from urokinase receptor (u-PAR)-deficient mice in the presence of carcinoma cells. Thromb Res 113:41\u201349","journal-title":"Thromb Res"},{"key":"2718_CR38","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1038\/sj.onc.1210066","volume":"26","author":"M Jo","year":"2007","unstructured":"Jo M, Thomas KS, Takimoto S, Gaultier A, Hsieh EH, Lester RD, Gonias SL (2007) Urokinase receptor primes cells to proliferate in response to epidermal growth factor. Oncogene 26:2585\u20132594","journal-title":"Oncogene"},{"key":"2718_CR39","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0014-5793(91)81042-7","volume":"288","author":"E R\u00f8nne","year":"1991","unstructured":"R\u00f8nne E, Behrendt N, Ellis V, Ploug M, Dan\u00f8 K, H\u00f8yer-Hansen G (1991) Cell-induced potentiation of the plasminogen activation system is abolished by a monoclonal antibody that recognizes the NH2-terminal domain of the urokinase receptor. FEBS Lett 288:233\u2013236","journal-title":"FEBS Lett"},{"key":"2718_CR40","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.jim.2005.10.013","volume":"308","author":"M Resnati","year":"2006","unstructured":"Resnati M, Pallavicini I, Daverio R, Sidenius N, Bonini P, Blasi F (2006) Specific immunofluorimetric assay detecting the chemotactic epitope of the urokinase receptor (uPAR). J Immunol Methods 308:192\u2013202","journal-title":"J Immunol Methods"},{"key":"2718_CR41","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1182\/blood.V94.2.649","volume":"94","author":"B Degryse","year":"1999","unstructured":"Degryse B, Resnati M, Rabbani SA, Villa A, Fazioli F, Blasi F (1999) Src-dependence and pertussis-toxin sensitivity of urokinase receptor-dependent chemotaxis and cytoskeleton reorganization in rat smooth muscle cells. Blood 94:649\u2013662","journal-title":"Blood"},{"key":"2718_CR42","doi-asserted-by":"crossref","first-page":"8655","DOI":"10.1016\/S0021-9258(18)31492-3","volume":"266","author":"MT Masucci","year":"1991","unstructured":"Masucci MT, Pedersen N, Blasi F (1991) A soluble, ligand binding mutant of the human urokinase plasminogen activator receptor. J Biol Chem 266:8655\u20138658","journal-title":"J Biol Chem"},{"key":"2718_CR43","doi-asserted-by":"crossref","first-page":"3918","DOI":"10.1073\/pnas.74.9.3918","volume":"74","author":"RM Pruss","year":"1977","unstructured":"Pruss RM, Herschman HR (1977) Variants of 3T3 cells lacking mitogenic response to epidermal growth factor. Proc Natl Acad Sci USA 74:3918\u20133921","journal-title":"Proc Natl Acad Sci USA"},{"key":"2718_CR44","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0092-8674(87)90147-4","volume":"51","author":"AM Honegger","year":"1987","unstructured":"Honegger AM, Dull TJ, Felder S, Van Obberghen E, Bellot F, Szapary D, Schmidt A, Ullrich A, Schlessinger J (1987) Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing. Cell 51:199\u2013209","journal-title":"Cell"},{"key":"2718_CR45","doi-asserted-by":"crossref","first-page":"4568","DOI":"10.1128\/MCB.7.12.4568","volume":"7","author":"AM Honegger","year":"1987","unstructured":"Honegger AM, Szapary D, Schmidt A, Lyall R, Van Obberghen E, Dull TJ, Ullrich A, Schlessinger J (1987) A mutant epidermal growth factor receptor with defective protein tyrosine kinase is unable to stimulate proto-oncogene expression and DNA synthesis. Mol Cell Biol 7:4568\u20134571","journal-title":"Mol Cell Biol"},{"key":"2718_CR46","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1038\/sj.onc.1204261","volume":"20","author":"B Degryse","year":"2001","unstructured":"Degryse B, Orlando S, Resnati M, Rabbani SA, Blasi F (2001) Urokinase\/urokinase receptor and vitronectin\/\u03b1v\u03b23 integrin induce chemotaxis and cytoskeleton reorganization through different signaling pathways. Oncogene 20:2032\u20132043","journal-title":"Oncogene"},{"key":"2718_CR47","doi-asserted-by":"crossref","first-page":"9405","DOI":"10.1074\/jbc.M109101200","volume":"277","author":"L Moro","year":"2002","unstructured":"Moro L, Dolce L, Cabodi S, Bergatto E, Boeri Erba E, Smeriglio M, Turco E, Retta SF, Giuffrida MG, Venturino M, Godovac-Zimmermann J, Conti A, Schaefer E, Beguinot L, Tacchetti C, Gaggini P, Silengo L, Tarone G, Defilippi P (2002) Integrin-induced epidermal growth factor (EGF) receptor activation requires c-Src and p130Cas and leads to phosphorylation of specific EGF receptor tyrosines. J Biol Chem 277:9405\u20139414","journal-title":"J Biol Chem"},{"key":"2718_CR48","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1091\/mbc.E05-07-0635","volume":"17","author":"R Mazzieri","year":"2006","unstructured":"Mazzieri R, D\u2019Alessio S, Kenmoe RK, Ossowski L, Blasi F (2006) An uncleavable uPAR mutant allows dissection of signaling pathways in uPA-dependent cell migration. Mol Biol Cell 17:367\u2013378","journal-title":"Mol Biol Cell"},{"key":"2718_CR49","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1051\/epn\/19861701011","volume":"17","author":"K W\u00fcthrich","year":"1986","unstructured":"W\u00fcthrich K (1986) NMR with proteins and nucleic acids. Europhys News 17:11\u201313","journal-title":"Europhys News"},{"key":"2718_CR50","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1084\/jem.181.4.1381","volume":"181","author":"J Bohuslav","year":"1995","unstructured":"Bohuslav J, Horejs\u00ed V, Hansmann C, St\u00f6ckl J, Weidle UH, Majdic O, Bartke I, Knapp W, Stockinger H (1995) Urokinase plasminogen activator receptor, beta 2-integrins, and Src-kinases within a single receptor complex of human monocytes. J Exp Med 181:1381\u20131390","journal-title":"J Exp Med"},{"key":"2718_CR51","doi-asserted-by":"crossref","first-page":"3185","DOI":"10.1182\/blood.V88.8.3185.bloodjournal8883185","volume":"88","author":"DI Simon","year":"1996","unstructured":"Simon DI, Rao NK, Xu H, Wei Y, Majdic O, R\u00f8nne E, Kobzik L, Chapman HA (1996) Mac-1 (CD11b\/CD18) and the urokinase receptor (CD87) form a functional unit on monocytic cells. Blood 88:3185\u20133194","journal-title":"Blood"},{"key":"2718_CR52","doi-asserted-by":"publisher","first-page":"2756","DOI":"10.1038\/onc.2009.132","volume":"28","author":"Y Liu","year":"2009","unstructured":"Liu Y, Pixley R, Fusaro M, Godoy G, Kim E, Bromberg ME, Colman RW (2009) Cleaved high-molecular-weight kininogen and its domain 5 inhibit migration and invasion of human prostate cancer cells through the epidermal growth factor receptor pathway. Oncogene 28:2756\u20132765. https:\/\/doi.org\/10.1038\/onc.2009.132","journal-title":"Oncogene"},{"key":"2718_CR53","doi-asserted-by":"publisher","first-page":"3922","DOI":"10.1242\/jcs.037549","volume":"121","author":"S D\u2019Alessio","year":"2008","unstructured":"D\u2019Alessio S, Gerasi L, Blasi F (2008) uPAR-deficient mouse keratinocytes fail to produce EGFR-dependent laminin-5, affecting migration in vivo and in vitro. J Cell Sci 121:3922\u20133932. https:\/\/doi.org\/10.1242\/jcs.037549","journal-title":"J Cell Sci"},{"key":"2718_CR54","doi-asserted-by":"crossref","first-page":"32380","DOI":"10.1016\/S0021-9258(18)31646-6","volume":"269","author":"Y Wei","year":"1994","unstructured":"Wei Y, Waltz DA, Rao N, Drummond RJ, Rosenberg S, Chapman HA (1994) Identification of the urokinase receptor as an adhesion receptor for vitronectin. J Biol Chem 269:32380\u201332388","journal-title":"J Biol Chem"},{"key":"2718_CR55","doi-asserted-by":"crossref","first-page":"35000","DOI":"10.1074\/jbc.273.52.35000","volume":"273","author":"RE Carter","year":"1998","unstructured":"Carter RE, Sorkin A (1998) Endocytosis of functional epidermal growth factor receptor-green fluorescent protein chimera. J Biol Chem 273:35000\u201335007","journal-title":"J Biol Chem"},{"key":"2718_CR56","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/1476-4598-7-47","volume":"7","author":"S Abu-Ali","year":"2008","unstructured":"Abu-Ali S, Fotovati A, Shirasuna K (2008) Tyrosine-kinase inhibition results in EGFR clustering at focal adhesions and consequent exocytosis in uPAR down-regulated cells of head and neck cancers. Mol Cancer 7:47. https:\/\/doi.org\/10.1186\/1476-4598-7-47","journal-title":"Mol Cancer"},{"key":"2718_CR57","doi-asserted-by":"publisher","first-page":"15984","DOI":"10.1073\/pnas.1113416108","volume":"108","author":"J Hu","year":"2011","unstructured":"Hu J, Jo M, Cavenee WK, Furnari F, VandenBerg SR, Gonias SL (2011) Crosstalk between the urokinase-type plasminogen activator receptor and EGF receptor variant III supports survival and growth of glioblastoma cells. Proc Natl Acad Sci USA 108:15984\u201315989. https:\/\/doi.org\/10.1073\/pnas.1113416108","journal-title":"Proc Natl Acad Sci USA"},{"key":"2718_CR58","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1158\/0008-5472.CAN-14-2004","volume":"75","author":"J Wykosky","year":"2015","unstructured":"Wykosky J, Hu J, Gomez GG, Taylor T, Villa GR, Pizzo D, VandenBerg SR, Thorne AH, Chen CC, Mischel PS, Gonias SL, Cavenee WK, Furnari FB (2015) A urokinase receptor-Bim signaling axis emerges during EGFR inhibitor resistance in mutant EGFR glioblastoma. Cancer Res 75:394\u2013404. https:\/\/doi.org\/10.1158\/0008-5472.CAN-14-2004","journal-title":"Cancer Res"},{"key":"2718_CR59","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/sj.onc.1209833","volume":"26","author":"R Mazzieri","year":"2007","unstructured":"Mazzieri R, Furlan F, D\u2019Alessio S, Zonari E, Talotta F, Verde P, Blasi F (2007) A direct link between expression of urokinase plasminogen activator receptor, growth rate and oncogenic transformation in mouse embryonic fibroblasts. Oncogene 26:725\u2013732","journal-title":"Oncogene"},{"key":"2718_CR60","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S0014-5793(99)01314-9","volume":"460","author":"N Montuori","year":"1999","unstructured":"Montuori N, Rossi G, Ragno P (1999) Cleavage of urokinase receptor regulates its interaction with integrins in thyroid cells. FEBS Lett 460:32\u201336","journal-title":"FEBS Lett"},{"key":"2718_CR61","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1196\/annals.1397.015","volume":"1095","author":"EJ Lee","year":"2007","unstructured":"Lee EJ, Whang JH, Jeon NK, Kim J (2007) The epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 (Iressa) suppresses proliferation and invasion of human oral squamous carcinoma cells via p53 independent and MMP, uPAR dependent mechanism. Ann N Y Acad Sci 1095:113\u2013128","journal-title":"Ann N Y Acad Sci"},{"key":"2718_CR62","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1083\/jcb.135.6.1633","volume":"135","author":"S Miyamoto","year":"1996","unstructured":"Miyamoto S, Teramoto H, Gutkind JS, Yamada KM (1996) Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors. J Cell Biol 135:1633\u20131642","journal-title":"J Cell Biol"},{"key":"2718_CR63","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1242\/jcs.113.12.2139","volume":"113","author":"X Yu","year":"2000","unstructured":"Yu X, Miyamoto S, Mekada E (2000) Integrin alpha 2 beta 1-dependent EGF receptor activation at cell-cell contact sites. J Cell Sci 113:2139\u20132147","journal-title":"J Cell Sci"},{"key":"2718_CR64","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1091\/mbc.11.7.2485","volume":"11","author":"SK Kuwada","year":"2000","unstructured":"Kuwada SK, Li X (2000) Integrin alpha5\/beta1 mediates fibronectin-dependent epithelial cell proliferation through epidermal growth factor receptor activation. Mol Biol Cell 11:2485\u20132496","journal-title":"Mol Biol Cell"},{"key":"2718_CR65","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1042\/BJ20081948","volume":"418","author":"CH Streuli","year":"2009","unstructured":"Streuli CH, Akhtar N (2009) Signal co-operation between integrins and other receptor systems. Biochem J 418:491\u2013506. https:\/\/doi.org\/10.1042\/BJ20081948","journal-title":"Biochem J"},{"key":"2718_CR66","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/S0092-8674(02)00966-2","volume":"110","author":"J Schlessinger","year":"2002","unstructured":"Schlessinger J (2002) Ligand-induced, receptor-mediated dimerization and activation of EGF receptor. Cell 110:669\u2013672","journal-title":"Cell"},{"key":"2718_CR67","doi-asserted-by":"publisher","first-page":"718","DOI":"10.4161\/cbt.12.8.16907","volume":"12","author":"ME Irwin","year":"2011","unstructured":"Irwin ME, Bohin N, Boerner JL (2011) Src family kinases mediate epidermal growth factor receptor signaling from lipid rafts in breast cancer cells. Cancer Biol Ther 12:718\u2013726. https:\/\/doi.org\/10.4161\/cbt.12.8.16907","journal-title":"Cancer Biol Ther"},{"key":"2718_CR68","doi-asserted-by":"crossref","first-page":"24252","DOI":"10.1074\/jbc.M200437200","volume":"277","author":"W Wu","year":"2002","unstructured":"Wu W, Graves LM, Gill GN, Parsons SJ, Samet JM (2002) Src-dependent phosphorylation of the epidermal growth factor receptor on tyrosine 845 is required for zinc-induced Ras activation. J Biol Chem 277:24252\u201324257","journal-title":"J Biol Chem"},{"key":"2718_CR69","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1074\/jbc.M210877200","volume":"278","author":"M Jo","year":"2003","unstructured":"Jo M, Thomas KS, O\u2019Donnell DM, Gonias SL (2003) Epidermal growth factor receptor-dependent and -independent cell-signaling pathways originating from the urokinase receptor. J Biol Chem 278:1642\u20131646","journal-title":"J Biol Chem"},{"key":"2718_CR70","doi-asserted-by":"crossref","first-page":"315","DOI":"10.4161\/cc.1.5.145","volume":"1","author":"PJ Stork","year":"2002","unstructured":"Stork PJ (2002) ERK signaling: duration, duration, duration. Cell Cycle 1:315\u2013317","journal-title":"Cell Cycle"},{"key":"2718_CR71","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.2174\/138161211796718233","volume":"17","author":"MC Boonstra","year":"2011","unstructured":"Boonstra MC, Verspaget HW, Ganesh S, Kubben FJ, Vahrmeijer AL, van de Velde CJ, Kuppen PJ, Quax PH, Sier CF (2011) Clinical applications of the urokinase receptor (uPAR) for cancer patients. Curr Pharm Des 17:1890\u20131910","journal-title":"Curr Pharm Des"},{"key":"2718_CR72","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1083\/jcb.137.3.767","volume":"137","author":"W Yu","year":"1997","unstructured":"Yu W, Kim J, Ossowski L (1997) Reduction in surface urokinase receptor forces malignant cells into a protracted state of dormancy. J Cell Biol 137:767\u2013777","journal-title":"J Cell Biol"},{"key":"2718_CR73","doi-asserted-by":"crossref","first-page":"17758","DOI":"10.1074\/jbc.M601812200","volume":"30","author":"D Alfano","year":"2006","unstructured":"Alfano D, Iaccarino I, Stoppelli MP (2006) Urokinase signaling through its receptor protects against anoikis by increasing BCL-xL expression levels. J Biol Chem 30:17758\u201317767","journal-title":"J Biol Chem"},{"key":"2718_CR74","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1042\/BJ20071652","volume":"415","author":"N Tkachuk","year":"2008","unstructured":"Tkachuk N, Kiyan J, Tkachuk S, Kiyan R, Shushakova N, Haller H, Dumler I (2008) Urokinase induces survival or pro-apoptotic signals in human mesangial cells depending on the apoptotic stimulus. Biochem J 415:265\u2013273. https:\/\/doi.org\/10.1042\/BJ20071652","journal-title":"Biochem J"},{"key":"2718_CR75","doi-asserted-by":"crossref","first-page":"3983","DOI":"10.1002\/j.1460-2075.1994.tb06714.x","volume":"13","author":"YH Kook","year":"1994","unstructured":"Kook YH, Adamski J, Zelent A, Ossowski L (1994) The effect of antisense inhibition of urokinase receptor in human squamous cell carcinoma on malignancy. EMBO J 13:3983\u20133991","journal-title":"EMBO J"},{"key":"2718_CR76","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/ng956","volume":"32","author":"AH Lund","year":"2002","unstructured":"Lund AH, Turner G, Trubetskoy A, Verhoeven E, Wientjens E, Hulsman D, Russell R, DePinho RA, Lenz J, van Lohuizen M (2002) Genome-wide retroviral insertional tagging of genes involved in cancer in Cdkn2a-deficient mice. Nat Genet 32:160\u2013165","journal-title":"Nat Genet"},{"key":"2718_CR77","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1158\/0008-5472.CAN-08-2331","volume":"69","author":"H Schnidar","year":"2009","unstructured":"Schnidar H, Eberl M, Klingler S, Mangelberger D, Kasper M, Hauser-Kronberger C, Regl G, Kroismayr R, Moriggl R, Sibilia M, Aberger F (2009) Epidermal growth factor receptor signaling synergizes with Hedgehog\/GLI in oncogenic transformation via activation of the MEK\/ERK\/JUN pathway. Cancer Res 69:1284\u20131292. https:\/\/doi.org\/10.1158\/0008-5472.CAN-08-2331","journal-title":"Cancer Res"},{"key":"2718_CR78","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/376337a0","volume":"376","author":"PJ Miettinen","year":"1995","unstructured":"Miettinen PJ, Berger JE, Meneses J, Phung Y, Pedersen RA, Werb Z, Derynck R (1995) Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor. Nature 376:337\u2013341","journal-title":"Nature"},{"key":"2718_CR79","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1111\/j.1432-0436.2007.00238.x","volume":"75","author":"M Sibilia","year":"2007","unstructured":"Sibilia M, Kroismayr R, Lichtenberger BM, Natarajan A, Hecking M, Holcmann M (2007) The epidermal growth factor receptor: from development to tumorigenesis. Differentiation 75:770\u2013787","journal-title":"Differentiation"},{"key":"2718_CR80","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1242\/dev.126.12.2739","volume":"126","author":"NC Luetteke","year":"1999","unstructured":"Luetteke NC, Qiu TH, Fenton SE, Troyer KL, Riedel RF, Chang A, Lee DC (1999) Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development. Development 126:2739\u20132750","journal-title":"Development"},{"key":"2718_CR81","doi-asserted-by":"crossref","first-page":"16886","DOI":"10.1074\/jbc.270.28.16886","volume":"270","author":"TH Bugge","year":"1995","unstructured":"Bugge TH, Suh TT, Flick MJ, Daugherty CC, R\u00f8mer J, Solberg H, Ellis V, Dan\u00f8 K, Degen JL (1995) The receptor for urokinase-type plasminogen activator is not essential for mouse development or fertility. J Biol Chem 270:16886\u201316894","journal-title":"J Biol Chem"},{"key":"2718_CR82","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1172\/JCI118489","volume":"97","author":"M Dewerchin","year":"1996","unstructured":"Dewerchin M, Nuffelen AV, Wallays G, Bouch\u00e9 A, Moons L, Carmeliet P, Mulligan RC, Collen D (1996) Generation and characterization of urokinase receptor-deficient mice. J Clin Investig 97:870\u2013878","journal-title":"J Clin Investig"},{"key":"2718_CR83","doi-asserted-by":"publisher","first-page":"190","DOI":"10.2353\/ajpath.2009.081053","volume":"175","author":"M Jo","year":"2009","unstructured":"Jo M, Takimoto S, Montel V, Gonias SL (2009) The urokinase receptor promotes cancer metastasis independently of urokinase-type plasminogen activator in mice. Am J Pathol 175:190\u2013200. https:\/\/doi.org\/10.2353\/ajpath.2009.081053","journal-title":"Am J Pathol"},{"key":"2718_CR84","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1007\/s10585-015-9726-1","volume":"32","author":"K Almholt","year":"2015","unstructured":"Almholt K, L\u00e6rum OD, Nielsen BS, Lund IK, Lund LR, R\u00f8mer J, J\u00f6gi A (2015) Spontaneous lung and lymph node metastasis in transgenic breast cancer is independent of the urokinase receptor uPAR. Clin Exp Metastasis 32:543\u2013554. https:\/\/doi.org\/10.1007\/s10585-015-9726-1","journal-title":"Clin Exp Metastasis"},{"key":"2718_CR85","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1593\/neo.12442","volume":"14","author":"NN Al-Hassan","year":"2012","unstructured":"Al-Hassan NN, Behzadian A, Caldwell R, Ivanova VS, Syed V, Motamed K, Said NA (2012) Differential roles of uPAR in peritoneal ovarian carcinomatosis. Neoplasia 14:259\u2013270","journal-title":"Neoplasia"},{"issue":"178\u2013190","key":"2718_CR86","doi-asserted-by":"publisher","first-page":"e10","DOI":"10.1053\/j.gastro.2017.03.053","volume":"153","author":"S Srivatsa","year":"2017","unstructured":"Srivatsa S, Paul MC, Cardone C, Holcmann M, Amberg N, Pathria P, Diamanti MA, Linder M, Timelthaler G, Dienes HP, Kenner L, Wrba F, Prager GW, Rose-John S, Eferl R, Liguori G, Botti G, Martinelli E, Greten FR, Ciardiello F, Sibilia M (2017) EGFR in tumor-associated myeloid cells promotes development of colorectal cancer in mice and associates with outcomes of patients. Gastroenterology 153(178\u2013190):e10. https:\/\/doi.org\/10.1053\/j.gastro.2017.03.053","journal-title":"Gastroenterology"},{"key":"2718_CR87","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s10911-007-9040-x","volume":"12","author":"K Almholt","year":"2007","unstructured":"Almholt K, Green KA, Juncker-Jensen A, Nielsen BS, Lund LR, R\u00f8mer J (2007) Extracellular proteolysis in transgenic mouse models of breast cancer. J Mammary Gland Biol Neoplasia 12:83\u201397","journal-title":"J Mammary Gland Biol Neoplasia"},{"key":"2718_CR88","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1083\/jcb.140.1.233","volume":"140","author":"P Carmeliet","year":"1998","unstructured":"Carmeliet P, Moons L, Dewerchin M, Rosenberg S, Herbert JM, Lupu F, Collen D (1998) Receptor-independent role of urokinase-type plasminogen activator in pericellular plasmin and matrix metalloproteinase proteolysis during vascular wound healing in mice. J Cell Biol 140:233\u2013245","journal-title":"J Cell Biol"},{"key":"2718_CR89","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/0092-8674(83)90093-4","volume":"35","author":"L Ossowski","year":"1983","unstructured":"Ossowski L, Reich E (1983) Antibodies to plasminogen activator inhibit human tumor metastasis. Cell 35:611\u2013619","journal-title":"Cell"},{"key":"2718_CR90","doi-asserted-by":"crossref","first-page":"39","DOI":"10.2174\/1381612043453559","volume":"10","author":"MJ Duffy","year":"2004","unstructured":"Duffy MJ (2004) The urokinase plasminogen activator system: role in malignancy. Curr Pharm Des 10:39\u201349","journal-title":"Curr Pharm Des"},{"key":"2718_CR91","first-page":"5839","volume":"60","author":"LS Gutierrez","year":"2000","unstructured":"Gutierrez LS, Schulman A, Brito-Robinson T, Noria F, Ploplis VA, Castellino FJ (2000) Tumor development is retarded in mice lacking the gene for urokinase-type plasminogen activator or its inhibitor, plasminogen activator inhibitor-1. Cancer Res 60:5839\u20135847","journal-title":"Cancer Res"},{"key":"2718_CR92","first-page":"532","volume":"61","author":"TL Frandsen","year":"2001","unstructured":"Frandsen TL, Holst-Hansen C, Nielsen BS, Christensen IJ, Nyengaard JR, Carmeliet P, Br\u00fcnner N (2001) Direct evidence of the importance of stromal urokinase plasminogen activator (uPA) in the growth of an experimental human breast cancer using a combined uPA gene-disrupted and immunodeficient xenograft model. Cancer Res 61:532\u2013537","journal-title":"Cancer Res"},{"key":"2718_CR93","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1164\/rccm.200903-0342OC","volume":"181","author":"I Henneke","year":"2010","unstructured":"Henneke I, Greschus S, Savai R, Korfei M, Markart P, Mahavadi P, Schermuly RT, Wygrecka M, St\u00fcrzebecher J, Seeger W, G\u00fcnther A, Ruppert C (2010) Inhibition of urokinase activity reduces primary tumor growth and metastasis formation in a murine lung carcinoma model. Am J Respir Crit Care Med 181:611\u2013619. https:\/\/doi.org\/10.1164\/rccm.200903-0342OC","journal-title":"Am J Respir Crit Care Med"},{"key":"2718_CR94","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1593\/neo.10728","volume":"13","author":"J Zhang","year":"2011","unstructured":"Zhang J, Sud S, Mizutani K, Gyetko MR, Pienta KJ (2011) Activation of urokinase plasminogen activator and its receptor axis is essential for macrophage infiltration in a prostate cancer mouse model. Neoplasia 13:23\u201330","journal-title":"Neoplasia"},{"key":"2718_CR95","first-page":"3597","volume":"56","author":"RL Shapiro","year":"1996","unstructured":"Shapiro RL, Duquette JG, Roses DF, Nunes I, Harris MN, Kamino H, Wilson EL, Rifkin DB (1996) Induction of primary cutaneous melanocytic neoplasms in urokinase-type plasminogen activator (uPA)-deficient and wild-type mice: cellular blue nevi invade but do not progress to malignant melanoma in uPA-deficient animals. Cancer Res 56:3597\u20133604","journal-title":"Cancer Res"},{"key":"2718_CR96","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/ijc.20631","volume":"113","author":"K Almholt","year":"2005","unstructured":"Almholt K, Lund LR, Rygaard J, Nielsen BS, Dan\u00f8 K, R\u00f8mer J, Johnsen M (2005) Reduced metastasis of transgenic mammary cancer in urokinase-deficient mice. Int J Cancer 113:525\u2013532","journal-title":"Int J Cancer"},{"issue":"174\u2013187","key":"2718_CR97","doi-asserted-by":"publisher","first-page":"e5","DOI":"10.1016\/j.tranon.2014.02.002","volume":"7","author":"E Karamanavi","year":"2014","unstructured":"Karamanavi E, Angelopoulou K, Lavrentiadou S, Tsingotjidou A, Abas Z, Taitzoglou I, Vlemmas I, Erdman SE, Poutahidis T (2014) Urokinase-type plasminogen activator deficiency promotes neoplasmatogenesis in the colon of mice. Transl Oncol 7(174\u2013187):e5. https:\/\/doi.org\/10.1016\/j.tranon.2014.02.002","journal-title":"Transl Oncol"},{"key":"2718_CR98","doi-asserted-by":"publisher","first-page":"1847","DOI":"10.1016\/j.cellsig.2012.05.011","volume":"24","author":"BM Eastman","year":"2012","unstructured":"Eastman BM, Jo M, Webb DL, Takimoto S, Gonias SL (2012) A transformation in the mechanism by which the urokinase receptor signals provides a selection advantage for estrogen receptor-expressing breast cancer cells in the absence of estrogen. Cell Signal 24:1847\u20131855. https:\/\/doi.org\/10.1016\/j.cellsig.2012.05.011","journal-title":"Cell Signal"},{"key":"2718_CR99","doi-asserted-by":"publisher","first-page":"8948","DOI":"10.1158\/0008-5472.CAN-10-1936","volume":"70","author":"M Jo","year":"2010","unstructured":"Jo M, Eastman BM, Webb DL, Stoletov K, Klemke R, Gonias SL (2010) Cell signaling by urokinase-type plasminogen activator receptor induces stem cell-like properties in breast cancer cells. Cancer Res 70:8948\u20138958. https:\/\/doi.org\/10.1158\/0008-5472.CAN-10-1936","journal-title":"Cancer Res"},{"key":"2718_CR100","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0022-4804(03)00004-0","volume":"110","author":"JE Bartsch","year":"2003","unstructured":"Bartsch JE, Staren ED, Appert HE (2003) Adhesion and migration of extracellular matrix-stimulated breast cancer. J Surg Res 110:287\u2013294","journal-title":"J Surg Res"},{"key":"2718_CR101","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1083\/jcb.200612058","volume":"177","author":"CD Madsen","year":"2007","unstructured":"Madsen CD, Ferraris GM, Andolfo A, Cunningham O, Sidenius N (2007) uPAR-induced cell adhesion and migration: vitronectin provides the key. J Cell Biol 177:927\u2013939","journal-title":"J Cell Biol"},{"key":"2718_CR102","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1002\/stem.271","volume":"28","author":"EM Hurt","year":"2010","unstructured":"Hurt EM, Chan K, Serrat MA, Thomas SB, Veenstra TD, Farrar WL (2010) Identification of vitronectin as an extrinsic inducer of cancer stem cell differentiation and tumor formation. Stem Cells 28:390\u2013398. https:\/\/doi.org\/10.1002\/stem.271","journal-title":"Stem Cells"},{"key":"2718_CR103","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1002\/iub.1203","volume":"65","author":"DI Leavesley","year":"2013","unstructured":"Leavesley DI, Kashyap AS, Croll T, Sivaramakrishnan M, Shokoohmand A, Hollier BG, Upton Z (2013) Vitronectin\u2014master controller or micromanager? IUBMB Life 65:807\u2013818. https:\/\/doi.org\/10.1002\/iub.1203","journal-title":"IUBMB Life"},{"key":"2718_CR104","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/nm0102-14","volume":"8","author":"P Carmeliet","year":"2002","unstructured":"Carmeliet P (2002) Integrin indecision. Nat Med 8:14\u201316","journal-title":"Nat Med"},{"key":"2718_CR105","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/nm0102-27","volume":"8","author":"LE Reynolds","year":"2002","unstructured":"Reynolds LE, Wyder L, Lively JC, Taverna D, Robinson SD, Huang X, Sheppard D, Hynes RO, Hodivala-Dilke KM (2002) Enhanced pathological angiogenesis in mice lacking beta3 integrin or beta3 and beta5 integrins. Nat Med 8:27\u201334","journal-title":"Nat Med"},{"key":"2718_CR106","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1073\/pnas.0307289101","volume":"101","author":"D Taverna","year":"2004","unstructured":"Taverna D, Moher H, Crowley D, Borsig L, Varki A, Hynes RO (2004) Increased primary tumor growth in mice null for beta3- or beta3\/beta5-integrins or selectins. Proc Natl Acad Sci USA 101:763\u2013768","journal-title":"Proc Natl Acad Sci USA"},{"key":"2718_CR107","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1084\/jem.20060807","volume":"203","author":"GH Mahabeleshwar","year":"2006","unstructured":"Mahabeleshwar GH, Feng W, Phillips DR, Byzova TV (2006) Integrin signaling is critical for pathological angiogenesis. J Exp Med 203:2495\u20132507","journal-title":"J Exp Med"},{"key":"2718_CR108","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1164\/rccm.201108-1381OC","volume":"185","author":"G Su","year":"2012","unstructured":"Su G, Atakilit A, Li JT, Wu N, Bhattacharya M, Zhu J, Shieh JE, Li E, Chen R, Sun S, Su CP, Sheppard D (2012) Absence of integrin \u03b1v\u03b23 enhances vascular leak in mice by inhibiting endothelial cortical actin formation. Am J Respir Crit Care Med 185:58\u201366. https:\/\/doi.org\/10.1164\/rccm.201108-1381OC","journal-title":"Am J Respir Crit Care Med"},{"key":"2718_CR109","doi-asserted-by":"crossref","first-page":"14205","DOI":"10.1073\/pnas.2234372100","volume":"100","author":"SJ Bakewell","year":"2003","unstructured":"Bakewell SJ, Nestor P, Prasad S, Tomasson MH, Dowland N, Mehrotra M, Scarborough R, Kanter J, Abe K, Phillips D, Weilbaecher KN (2003) Platelet and osteoclast beta3 integrins are critical for bone metastasis. Proc Natl Acad Sci USA 100:14205\u201314210","journal-title":"Proc Natl Acad Sci USA"},{"key":"2718_CR110","doi-asserted-by":"crossref","first-page":"53848","DOI":"10.1074\/jbc.M403114200","volume":"279","author":"K Wang","year":"2004","unstructured":"Wang K, Yamamoto H, Chin JR, Werb Z, Vu TH (2004) Epidermal growth factor receptor-deficient mice have delayed primary endochondral ossification because of defective osteoclast recruitment. J Biol Chem 279:53848\u201353856","journal-title":"J Biol Chem"},{"key":"2718_CR111","doi-asserted-by":"crossref","first-page":"4515","DOI":"10.1242\/dev.00664","volume":"130","author":"M Sibilia","year":"2003","unstructured":"Sibilia M, Wagner B, Hoebertz A, Elliott C, Marino S, Jochum W, Wagner EF (2003) Mice humanised for the EGF receptor display hypomorphic phenotypes in skin, bone and heart. Development 130:4515\u20134525","journal-title":"Development"},{"key":"2718_CR112","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1359\/jbmr.070516","volume":"22","author":"F Furlan","year":"2007","unstructured":"Furlan F, Galbiati C, Jorgensen NR, Jensen JE, Mrak E, Rubinacci A, Talotta F, Verde P, Blasi F (2007) Urokinase plasminogen activator receptor affects bone homeostasis by regulating osteoblast and osteoclast function. J Bone Miner Res 22:1387\u20131396","journal-title":"J Bone Miner Res"}],"container-title":["Cellular and Molecular Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00018-017-2718-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-017-2718-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-017-2718-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T07:50:07Z","timestamp":1660031407000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00018-017-2718-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,28]]},"references-count":112,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["2718"],"URL":"https:\/\/doi.org\/10.1007\/s00018-017-2718-3","relation":{},"ISSN":["1420-682X","1420-9071"],"issn-type":[{"value":"1420-682X","type":"print"},{"value":"1420-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,28]]}}}