{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T01:01:48Z","timestamp":1790470908657,"version":"4.1.0"},"reference-count":273,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T00:00:00Z","timestamp":1544054400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1092642"],"award-info":[{"award-number":["1092642"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1092642"],"award-info":[{"award-number":["1092642"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1092642"],"award-info":[{"award-number":["1092642"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1092642"],"award-info":[{"award-number":["1092642"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1087355"],"award-info":[{"award-number":["1087355"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell. Mol. Life Sci."],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1007\/s00018-018-2984-8","type":"journal-article","created":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T10:13:20Z","timestamp":1544091200000},"page":"1107-1134","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["The role of dihydrosphingolipids in disease"],"prefix":"10.1007","volume":"76","author":[{"given":"Ruth. R.","family":"Magaye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feby","family":"Savira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren J.","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Reid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Flynn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny","family":"Liew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing H.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,12,6]]},"reference":[{"issue":"1","key":"2984_CR1","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1194\/jlr.R031278","volume":"54","author":"MM Young","year":"2013","unstructured":"Young MM, Kester M, Wang H-G (2013) Sphingolipids: regulators of crosstalk between apoptosis and autophagy. J Lipid Res 54(1):5\u201319. https:\/\/doi.org\/10.1194\/jlr.R031278","journal-title":"J Lipid Res"},{"issue":"7","key":"2984_CR2","doi-asserted-by":"publisher","first-page":"2070","DOI":"10.1073\/pnas.0305799101","volume":"101","author":"RG Cutler","year":"2004","unstructured":"Cutler RG, Kelly J, Storie K, Pedersen WA, Tammara A, Hatanpaa K, Troncoso JC, Mattson MP (2004) Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer\u2019s disease. Proc Natl Acad Sci USA 101(7):2070\u20132075. https:\/\/doi.org\/10.1073\/pnas.0305799101","journal-title":"Proc Natl Acad Sci USA"},{"key":"2984_CR3","doi-asserted-by":"publisher","first-page":"7602526","DOI":"10.1155\/2016\/7602526","volume":"2016","author":"K Kitatani","year":"2016","unstructured":"Kitatani K, Iwabuchi K, Snider A, Riboni L (2016) Sphingolipids in inflammation: from bench to bedside. Mediators Inflamm 2016:7602526. https:\/\/doi.org\/10.1155\/2016\/7602526","journal-title":"Mediators Inflamm"},{"key":"2984_CR4","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/nrc.2017.96","volume":"18","author":"B Ogretmen","year":"2017","unstructured":"Ogretmen B (2017) Sphingolipid metabolism in cancer signalling and therapy. Nat Rev Cancer 18:33. https:\/\/doi.org\/10.1038\/nrc.2017.96","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"2984_CR5","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1159\/000362988","volume":"34","author":"R Halmer","year":"2014","unstructured":"Halmer R, Walter S, Fassbender K (2014) Sphingolipids: important players in multiple sclerosis. Cell Physiol Biochem 34(1):111\u2013118. https:\/\/doi.org\/10.1159\/000362988","journal-title":"Cell Physiol Biochem"},{"key":"2984_CR6","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1007\/978-3-7091-1511-4_19","volume":"216","author":"SB Russo","year":"2013","unstructured":"Russo SB, Ross JS, Cowart LA (2013) Sphingolipids in obesity, Type 2 diabetes, and metabolic disease. Handb Exp Pharmacol 216:373\u2013401. https:\/\/doi.org\/10.1007\/978-3-7091-1511-4_19","journal-title":"Handb Exp Pharmacol"},{"key":"2984_CR7","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7091-1511-4","volume-title":"Hand book of experimental pharmacology","author":"E Gulbins","year":"2013","unstructured":"Gulbins E, Petrache I (2013) Sphingolipids in disease. In: Gulbins E, Petrache I (eds) Hand book of experimental pharmacology, vol 216. Springer, Vienna. https:\/\/doi.org\/10.1007\/978-3-7091-1511-4"},{"issue":"3","key":"2984_CR8","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1111\/jnc.13964","volume":"141","author":"C Giles","year":"2017","unstructured":"Giles C, Takechi R, Mellett NA, Meikle PJ, Dhaliwal S, Mamo JC (2017) Differential regulation of sphingolipid metabolism in plasma, hippocampus, and cerebral cortex of mice administered sphingolipid modulating agents. J Neurochem 141(3):413\u2013422. https:\/\/doi.org\/10.1111\/jnc.13964","journal-title":"J Neurochem"},{"issue":"1","key":"2984_CR9","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.bbalip.2014.09.021","volume":"1851","author":"S Rodriguez-Cuenca","year":"2015","unstructured":"Rodriguez-Cuenca S, Barbarroja N, Vidal-Puig A (2015) Dihydroceramide desaturase 1, the gatekeeper of ceramide induced lipotoxicity. Biochim Biophys Acta Mol Cell Biol Lipids 1851(1):40\u201350. https:\/\/doi.org\/10.1016\/j.bbalip.2014.09.021","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"key":"2984_CR10","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/978-3-7091-1511-4_8","volume":"216","author":"B Levkau","year":"2013","unstructured":"Levkau B (2013) Cardiovascular effects of sphingosine-1-phosphate (S1P). Handb Exp Pharmacol 216:147\u2013170. https:\/\/doi.org\/10.1007\/978-3-7091-1511-4_8","journal-title":"Handb Exp Pharmacol"},{"key":"2984_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-3-319-20750-6_1","volume-title":"Bioactive sphingolipids in cancer biology and therapy","author":"C Colacios","year":"2015","unstructured":"Colacios C, Sabourdy F, Andrieu-Abadie N, S\u00e9gui B, Levade T (2015) Basics of Sphingolipid Metabolism and Signalling. In: Hannun YA, Luberto C, Mao C, Obeid LM (eds) Bioactive sphingolipids in cancer biology and therapy. Springer, Cham, pp 1\u201320. https:\/\/doi.org\/10.1007\/978-3-319-20750-6_1"},{"key":"2984_CR12","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1007\/978-1-4419-6741-1_4","volume":"688","author":"J Stiban","year":"2010","unstructured":"Stiban J, Tidhar R, Futerman AH (2010) Ceramide synthases: roles in cell physiology and signaling. Adv Exp Med Biol 688:60\u201371","journal-title":"Adv Exp Med Biol"},{"key":"2984_CR13","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1146\/annurev-physiol-021115-105221","volume":"78","author":"I Petrache","year":"2016","unstructured":"Petrache I, Berdyshev EV (2016) Ceramide signaling and metabolism in pathophysiological states of the lung. Annu Rev Physiol 78:463\u2013480. https:\/\/doi.org\/10.1146\/annurev-physiol-021115-105221","journal-title":"Annu Rev Physiol"},{"issue":"12","key":"2984_CR14","doi-asserted-by":"publisher","first-page":"1864","DOI":"10.1016\/j.bbamem.2006.08.009","volume":"1758","author":"W Zheng","year":"2006","unstructured":"Zheng W, Kollmeyer J, Symolon H, Momin A, Munter E, Wang E, Kelly S, Allegood JC, Liu Y, Peng Q, Ramaraju H, Sullards MC, Cabot M, Merrill AH (2006) Ceramides and other bioactive sphingolipid backbones in health and disease: lipidomic analysis, metabolism and roles in membrane structure, dynamics, signaling and autophagy. Biochim Biophys Acta Biomembr 1758(12):1864\u20131884. https:\/\/doi.org\/10.1016\/j.bbamem.2006.08.009","journal-title":"Biochim Biophys Acta Biomembr"},{"key":"2984_CR15","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.chemphyslip.2015.07.025","volume":"197","author":"M Casasampere","year":"2016","unstructured":"Casasampere M, Ordonez YF, Pou A, Casas J (2016) Inhibitors of dihydroceramide desaturase 1: therapeutic agents and pharmacological tools to decipher the role of dihydroceramides in cell biology. Chem Phys Lipids 197:33\u201344. https:\/\/doi.org\/10.1016\/j.chemphyslip.2015.07.025","journal-title":"Chem Phys Lipids"},{"issue":"9","key":"2984_CR16","doi-asserted-by":"publisher","first-page":"e44042","DOI":"10.1371\/journal.pone.0044042","volume":"7","author":"MM Siddique","year":"2012","unstructured":"Siddique MM, Bikman BT, Wang L, Ying L, Reinhardt E, Shui G, Wenk MR, Summers SA (2012) Ablation of dihydroceramide desaturase confers resistance to etoposide-induced apoptosis in vitro. PLoS One 7(9):e44042. https:\/\/doi.org\/10.1371\/journal.pone.0044042","journal-title":"PLoS One"},{"issue":"25","key":"2984_CR17","doi-asserted-by":"publisher","first-page":"15371","DOI":"10.1074\/jbc.R115.653204","volume":"290","author":"MM Siddique","year":"2015","unstructured":"Siddique MM, Li Y, Chaurasia B, Kaddai VA, Summers SA (2015) Dihydroceramides: from bit players to lead actors. J Biol Chem 290(25):15371\u201315379. https:\/\/doi.org\/10.1074\/jbc.R115.653204","journal-title":"J Biol Chem"},{"key":"2984_CR18","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.plipres.2016.03.006","volume":"63","author":"MS Wegner","year":"2016","unstructured":"Wegner MS, Schiffmann S, Parnham MJ, Geisslinger G, Grosch S (2016) The enigma of ceramide synthase regulation in mammalian cells. Prog Lipid Res 63:93\u2013119. https:\/\/doi.org\/10.1016\/j.plipres.2016.03.006","journal-title":"Prog Lipid Res"},{"key":"2984_CR19","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.chemphyslip.2015.07.026","volume":"197","author":"F Cingolani","year":"2016","unstructured":"Cingolani F, Futerman AH, Casas J (2016) Ceramide synthases in biomedical research. Chem Phys Lipids 197:25\u201332. https:\/\/doi.org\/10.1016\/j.chemphyslip.2015.07.026","journal-title":"Chem Phys Lipids"},{"key":"2984_CR20","first-page":"1618","volume":"13","author":"A Samadi","year":"2007","unstructured":"Samadi A (2007) Ceramide-induced cell death in lens epithelial cells. Mol Vis 13:1618\u20131626","journal-title":"Mol Vis"},{"issue":"2","key":"2984_CR21","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1002\/jcp.21613","volume":"218","author":"CC Chien","year":"2009","unstructured":"Chien CC, Shen SC, Yang LY, Wu CY, Liau JS, Chen YC (2009) Activation of telomerase and cyclooxygenase-2 in PDGF and FGF inhibition of C2-ceramide-induced apoptosis. J Cell Physiol 218(2):405\u2013415. https:\/\/doi.org\/10.1002\/jcp.21613","journal-title":"J Cell Physiol"},{"issue":"7","key":"2984_CR22","doi-asserted-by":"publisher","first-page":"3056","DOI":"10.1074\/jbc.270.7.3056","volume":"270","author":"K Wong","year":"1995","unstructured":"Wong K, Li X-B, Hunchuk N (1995) N-Acetylsphingosine (C-ceramide) inhibited neutrophil superoxide formation and calcium influx. J Biol Chem 270(7):3056\u20133062. https:\/\/doi.org\/10.1074\/jbc.270.7.3056","journal-title":"J Biol Chem"},{"issue":"4","key":"2984_CR23","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1111\/jnc.12836","volume":"131","author":"FD Testai","year":"2014","unstructured":"Testai FD, Kilkus JP, Berdyshev E, Gorshkova I, Natarajan V, Dawson G (2014) Multiple sphingolipid abnormalities following cerebral microendothelial hypoxia. J Neurochem 131(4):530\u2013540. https:\/\/doi.org\/10.1111\/jnc.12836","journal-title":"J Neurochem"},{"issue":"5","key":"2984_CR24","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1002\/jnr.23542","volume":"93","author":"FD Testai","year":"2015","unstructured":"Testai FD, Xu HL, Kilkus J, Suryadevara V, Gorshkova I, Berdyshev E, Pelligrino DA, Dawson G (2015) Changes in the metabolism of sphingolipids after subarachnoid hemorrhage. J Neurosci Res 93(5):796\u2013805. https:\/\/doi.org\/10.1002\/jnr.23542","journal-title":"J Neurosci Res"},{"issue":"14","key":"2984_CR25","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1212\/WNL.0000000000002004","volume":"85","author":"BL Peterlin","year":"2015","unstructured":"Peterlin BL, Mielke MM, Dickens AM, Chatterjee S, Dash P, Alexander G, Vieira RV, Bandaru VV, Dorskind JM, Tietjen GE, Haughey NH (2015) Interictal, circulating sphingolipids in women with episodic migraine: a case\u2013control study. Neurology 85(14):1214\u20131223. https:\/\/doi.org\/10.1212\/WNL.0000000000002004","journal-title":"Neurology"},{"issue":"6","key":"2984_CR26","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1136\/jmedgenet-2015-103457","volume":"53","author":"S Edvardson","year":"2016","unstructured":"Edvardson S, Yi JK, Jalas C, Xu R, Webb BD, Snider J, Fedick A, Kleinman E, Treff NR, Mao C, Elpeleg O (2016) Deficiency of the alkaline ceramidase ACER3 manifests in early childhood by progressive leukodystrophy. J Med Genet 53(6):389","journal-title":"J Med Genet"},{"issue":"46","key":"2984_CR27","doi-asserted-by":"publisher","first-page":"23978","DOI":"10.1074\/jbc.M116.737684","volume":"291","author":"M Park","year":"2016","unstructured":"Park M, Kaddai V, Ching J, Fridianto KT, Sieli RJ, Sugii S, Summers SA (2016) A role for ceramides, but not sphingomyelins, as antagonists of insulin signaling and mitochondrial metabolism in C2C12 myotubes. J Biol Chem 291(46):23978\u201323988","journal-title":"J Biol Chem"},{"issue":"1","key":"2984_CR28","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1042\/BJ20101386","volume":"438","author":"J Veret","year":"2011","unstructured":"Veret J, Coant N, Berdyshev EV, Skobeleva A, Therville N, Bailbe D, Gorshkova I, Natarajan V, Portha B, Le Stunff H (2011) Ceramide synthase 4 and de novo production of ceramides with specific N-acyl chain lengths are involved in glucolipotoxicity-induced apoptosis of INS-1 beta-cells. Biochem J 438(1):177\u2013189. https:\/\/doi.org\/10.1042\/BJ20101386","journal-title":"Biochem J"},{"issue":"4","key":"2984_CR29","doi-asserted-by":"publisher","first-page":"e0176391","DOI":"10.1371\/journal.pone.0176391","volume":"12","author":"K Roomp","year":"2017","unstructured":"Roomp K, Kristinsson H, Schvartz D, Ubhayasekera K, Sargsyan E, Manukyan L, Chowdhury A, Manell H, Satagopam V, Groebe K, Schneider R, Bergquist J, Sanchez J-C, Bergsten P (2017) Combined lipidomic and proteomic analysis of isolated human islets exposed to palmitate reveals time-dependent changes in insulin secretion and lipid metabolism. PLoS One 12(4):e0176391. https:\/\/doi.org\/10.1371\/journal.pone.0176391","journal-title":"PLoS One"},{"issue":"5\u20136","key":"2984_CR30","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/s10863-006-9052-z","volume":"38","author":"Y Li","year":"2006","unstructured":"Li Y, Park J-S, Deng J-H, Bai Y (2006) Cytochrome c oxidase Subunit IV is essential for assembly and respiratory function of the enzyme complex. J Bioenerg Biomembr 38(5\u20136):283\u2013291. https:\/\/doi.org\/10.1007\/s10863-006-9052-z","journal-title":"J Bioenerg Biomembr"},{"issue":"6","key":"2984_CR31","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1097\/SHK.0000000000000468","volume":"44","author":"ME Hansen","year":"2015","unstructured":"Hansen ME, Simmons KJ, Tippetts TS, Thatcher MO, Saito RR, Hubbard ST, Trumbull AM, Parker BA, Taylor OJ, Bikman BT (2015) Lipopolysaccharide disrupts mitochondrial physiology in skeletal muscle via disparate effects on sphingolipid metabolism. Shock 44(6):585\u2013592. https:\/\/doi.org\/10.1097\/SHK.0000000000000468","journal-title":"Shock"},{"issue":"5","key":"2984_CR32","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1007\/s10495-006-5882-8","volume":"11","author":"J Stiban","year":"2006","unstructured":"Stiban J, Fistere D, Colombini M (2006) Dihydroceramide hinders ceramide channel formation: implications on apoptosis. Apoptosis 11(5):773\u2013780. https:\/\/doi.org\/10.1007\/s10495-006-5882-8","journal-title":"Apoptosis"},{"issue":"4","key":"2984_CR33","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.2337\/db14-0359","volume":"64","author":"N Barbarroja","year":"2015","unstructured":"Barbarroja N, Rodriguez-Cuenca S, Nygren H, Camargo A, Pirraco A, Relat J, Cuadrado I, Pellegrinelli V, Medina-Gomez G, Lopez-Pedrera C, Tinahones FJ, Symons JD, Summers SA, Oresic M, Vidal-Puig A (2015) Increased dihydroceramide\/ceramide ratio mediated by defective expression of degs1 impairs adipocyte differentiation and function. Diabetes 64(4):1180\u20131192. https:\/\/doi.org\/10.2337\/db14-0359","journal-title":"Diabetes"},{"key":"2984_CR34","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.bcp.2015.11.017","volume":"100","author":"GD McIlroy","year":"2016","unstructured":"McIlroy GD, Tammireddy SR, Maskrey BH, Grant L, Doherty MK, Watson DG, Delibegovic M, Whitfield PD, Mody N (2016) Fenretinide mediated retinoic acid receptor signalling and inhibition of ceramide biosynthesis regulates adipogenesis, lipid accumulation, mitochondrial function and nutrient stress signalling in adipocytes and adipose tissue. Biochem Pharmacol 100:86\u201397. https:\/\/doi.org\/10.1016\/j.bcp.2015.11.017","journal-title":"Biochem Pharmacol"},{"issue":"4","key":"2984_CR35","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1210\/me.2013-1401","volume":"28","author":"ILMH Aye","year":"2014","unstructured":"Aye ILMH, Gao X, Weintraub ST, Jansson T, Powell TL (2014) Adiponectin inhibits insulin function in primary trophoblasts by PPAR\u03b1-mediated ceramide synthesis. Mol Endocrinol 28(4):512\u2013524. https:\/\/doi.org\/10.1210\/me.2013-1401","journal-title":"Mol Endocrinol"},{"issue":"8","key":"2984_CR36","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1038\/ijo.2012.191","volume":"37","author":"JT Brozinick","year":"2013","unstructured":"Brozinick JT, Hawkins E, Hoang Bui H, Kuo MS, Tan B, Kievit P, Grove K (2013) Plasma sphingolipids are biomarkers of metabolic syndrome in non-human primates maintained on a Western-style diet. Int J Obes 37(8):1064\u20131070. https:\/\/doi.org\/10.1038\/ijo.2012.191","journal-title":"Int J Obes"},{"issue":"21","key":"2984_CR37","doi-asserted-by":"publisher","first-page":"17426","DOI":"10.1074\/jbc.M112.359950","volume":"287","author":"BT Bikman","year":"2012","unstructured":"Bikman BT, Guan Y, Shui G, Siddique MM, Holland WL, Kim JY, Fabri\u00e0s G, Wenk MR, Summers SA (2012) Fenretinide prevents lipid-induced insulin resistance by blocking ceramide biosynthesis. J Biol Chem 287(21):17426\u201317437. https:\/\/doi.org\/10.1074\/jbc.M112.359950","journal-title":"J Biol Chem"},{"issue":"5","key":"2984_CR38","doi-asserted-by":"publisher","first-page":"e0176787","DOI":"10.1371\/journal.pone.0176787","volume":"12","author":"JE Rico","year":"2017","unstructured":"Rico JE, Saed Samii S, Mathews AT, Lovett J, Haughey NJ, McFadden JW (2017) Temporal changes in sphingolipids and systemic insulin sensitivity during the transition from gestation to lactation. PLoS One 12(5):e0176787. https:\/\/doi.org\/10.1371\/journal.pone.0176787","journal-title":"PLoS One"},{"issue":"6","key":"2984_CR39","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1111\/acel.12369","volume":"14","author":"MM Mielke","year":"2015","unstructured":"Mielke MM, Bandaru VV, Han D, An Y, Resnick SM, Ferrucci L, Haughey NJ (2015) Demographic and clinical variables affecting mid- to late-life trajectories of plasma ceramide and dihydroceramide species. Aging Cell 14(6):1014\u20131023. https:\/\/doi.org\/10.1111\/acel.12369","journal-title":"Aging Cell"},{"issue":"10","key":"2984_CR40","doi-asserted-by":"publisher","first-page":"2898","DOI":"10.1194\/jlr.P035808","volume":"54","author":"JM Weir","year":"2013","unstructured":"Weir JM, Wong G, Barlow CK, Greeve MA, Kowalczyk A, Almasy L, Comuzzie AG, Mahaney MC, Jowett JBM, Shaw J, Curran JE, Blangero J, Meikle PJ (2013) Plasma lipid profiling in a large population-based cohort. J Lipid Res 54(10):2898\u20132908. https:\/\/doi.org\/10.1194\/jlr.P035808","journal-title":"J Lipid Res"},{"issue":"3","key":"2984_CR41","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1002\/oby.20598","volume":"22","author":"M Mamtani","year":"2014","unstructured":"Mamtani M, Meikle PJ, Kulkarni H, Weir JM, Barlow CK, Jowett JB, Bellis C, Dyer TD, Almasy L, Mahaney MC, Duggirala R, Comuzzie AG, Blangero J, Curran JE (2014) Plasma dihydroceramide species associate with waist circumference in mexican american families. Obesity (Silver Spring, MD) 22(3):950\u2013956. https:\/\/doi.org\/10.1002\/oby.20598","journal-title":"Obesity (Silver Spring, MD)"},{"issue":"9","key":"2984_CR42","doi-asserted-by":"publisher","first-page":"e74341","DOI":"10.1371\/journal.pone.0074341","volume":"8","author":"PJ Meikle","year":"2013","unstructured":"Meikle PJ, Wong G, Barlow CK, Weir JM, Greeve MA, MacIntosh GL, Almasy L, Comuzzie AG, Mahaney MC, Kowalczyk A, Haviv I, Grantham N, Magliano DJ, Jowett JBM, Zimmet P, Curran JE, Blangero J, Shaw J (2013) Plasma lipid profiling shows similar associations with prediabetes and Type 2 diabetes. PLoS One 8(9):e74341. https:\/\/doi.org\/10.1371\/journal.pone.0074341","journal-title":"PLoS One"},{"issue":"9\u201310","key":"2984_CR43","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1515\/jpem-2012-0407","volume":"26","author":"X Lopez","year":"2013","unstructured":"Lopez X, Goldfine AB, Holland WL, Gordillo R, Scherer PE (2013) Plasma ceramides are elevated in female children and adolescents with type 2 diabetes. J Pediatr Endocrinol Metab 26(9\u201310):995\u2013998. https:\/\/doi.org\/10.1515\/jpem-2012-0407","journal-title":"J Pediatr Endocrinol Metab"},{"issue":"3","key":"2984_CR44","doi-asserted-by":"publisher","first-page":"673","DOI":"10.2337\/diacare.29.03.06.dc05-1605","volume":"29","author":"SB Racette","year":"2006","unstructured":"Racette SB, Evans EM, Weiss EP, Hagberg JM, Holloszy JO (2006) Abdominal adiposity is a stronger predictor of insulin resistance than fitness among 50\u201395 year olds. Diabetes Care 29(3):673\u2013678","journal-title":"Diabetes Care"},{"issue":"5","key":"2984_CR45","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1007\/s00125-011-2065-0","volume":"54","author":"JJ Dub\u00e9","year":"2011","unstructured":"Dub\u00e9 JJ, Amati F, Toledo FGS, Stefanovic-Racic M, Rossi A, Coen P, Goodpaster BH (2011) Effects of weight loss and exercise on insulin resistance, and intramyocellular triacylglycerol, diacylglycerol and ceramide. Diabetologia 54(5):1147\u20131156. https:\/\/doi.org\/10.1007\/s00125-011-2065-0","journal-title":"Diabetologia"},{"issue":"7","key":"2984_CR46","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1002\/dmrr.2662","volume":"31","author":"JT Warshauer","year":"2015","unstructured":"Warshauer JT, Lopez X, Gordillo R, Hicks J, Holland WL, Anuwe E, Blankfard MB, Scherer PE, Lingvay I (2015) Effect of pioglitazone on plasma ceramides in adults with metabolic syndrome. Diabetes Metab Res Rev 31(7):734\u2013744. https:\/\/doi.org\/10.1002\/dmrr.2662","journal-title":"Diabetes Metab Res Rev"},{"issue":"5","key":"2984_CR47","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1111\/acel.12491","volume":"15","author":"E Fabbri","year":"2016","unstructured":"Fabbri E, Yang A, Simonsick EM, Chia CW, Zoli M, Haughey NJ, Mielke MM, Ferrucci L, Coen PM (2016) Circulating ceramides are inversely associated with cardiorespiratory fitness in participants aged 54\u201396\u00a0years from the Baltimore Longitudinal Study of Aging. Aging Cell 15(5):825\u2013831. https:\/\/doi.org\/10.1111\/acel.12491","journal-title":"Aging Cell"},{"issue":"1\u20134","key":"2984_CR48","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.prostaglandins.2008.02.003","volume":"86","author":"L Noureddine","year":"2008","unstructured":"Noureddine L, Azzam R, Nemer G, Bielawski J, Nasser M, Bitar F, Dbaibo GS (2008) Modulation of total ceramide and constituent ceramide species in the acutely and chronically hypoxic mouse heart at different ages. Prostaglandins Other Lipid Mediat 86(1\u20134):49\u201355. https:\/\/doi.org\/10.1016\/j.prostaglandins.2008.02.003","journal-title":"Prostaglandins Other Lipid Mediat"},{"issue":"19","key":"2984_CR49","doi-asserted-by":"publisher","first-page":"13397","DOI":"10.1074\/jbc.M112.428185","volume":"288","author":"SB Russo","year":"2013","unstructured":"Russo SB, Tidhar R, Futerman AH, Cowart LA (2013) Myristate-derived d16:0 sphingolipids constitute a cardiac sphingolipid pool with distinct synthetic routes and functional properties. J Biol Chem 288(19):13397\u201313409. https:\/\/doi.org\/10.1074\/jbc.M112.428185","journal-title":"J Biol Chem"},{"issue":"6","key":"2984_CR50","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1161\/ATVBAHA.116.305675","volume":"36","author":"A Edsfeldt","year":"2016","unstructured":"Edsfeldt A, Dun\u00e9r P, St\u00e5hlman M, Mollet IG, Asciutto G, Grufman H, Nitulescu M, Persson AF, Fisher RM, Melander O, Orho-Melander M, Bor\u00e9n J, Nilsson J, Gon\u00e7alves I (2016) Sphingolipids contribute to human atherosclerotic plaque inflammation. Arterioscler Thromb Vasc Biol 36(6):1132","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"8","key":"2984_CR51","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1093\/ehjci\/jeu033","volume":"15","author":"AH Ellims","year":"2014","unstructured":"Ellims AH, Wong G, Weir JM, Lew P, Meikle PJ, Taylor AJ (2014) Plasma lipidomic analysis predicts non-calcified coronary artery plaque in asymptomatic patients at intermediate risk of coronary artery disease. Eur Heart J Cardiovasc Imaging 15(8):908\u2013916. https:\/\/doi.org\/10.1093\/ehjci\/jeu033","journal-title":"Eur Heart J Cardiovasc Imaging"},{"issue":"6","key":"2984_CR52","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1194\/jlr.M800427-JLR200","volume":"50","author":"H Hamai","year":"2009","unstructured":"Hamai H, Keyserman F, Quittell LM, Worgall TS (2009) Defective CFTR increases synthesis and mass of sphingolipids that modulate membrane composition and lipid signaling. J Lipid Res 50(6):1101\u20131108. https:\/\/doi.org\/10.1194\/jlr.M800427-JLR200","journal-title":"J Lipid Res"},{"issue":"9","key":"2984_CR53","doi-asserted-by":"publisher","first-page":"5467","DOI":"10.1074\/jbc.M805186200","volume":"284","author":"EV Berdyshev","year":"2009","unstructured":"Berdyshev EV, Gorshkova I, Skobeleva A, Bittman R, Lu X, Dudek SM, Mirzapoiazova T, Garcia JGN, Natarajan V (2009) FTY720 inhibits ceramide synthases and up-regulates dihydrosphingosine 1-phosphate formation in human lung endothelial cells. J Biol Chem 284(9):5467\u20135477. https:\/\/doi.org\/10.1074\/jbc.M805186200","journal-title":"J Biol Chem"},{"issue":"1","key":"2984_CR54","doi-asserted-by":"publisher","first-page":"e53927","DOI":"10.1371\/journal.pone.0053927","volume":"8","author":"M Yasuo","year":"2013","unstructured":"Yasuo M, Mizuno S, Allegood J, Kraskauskas D, Bogaard HJ, Spiegel S, Voelkel NF (2013) Fenretinide causes emphysema, which is prevented by sphingosine 1-phoshate. PLoS One 8(1):e53927. https:\/\/doi.org\/10.1371\/journal.pone.0053927","journal-title":"PLoS One"},{"issue":"44","key":"2984_CR55","doi-asserted-by":"publisher","first-page":"38069","DOI":"10.1074\/jbc.M111.297994","volume":"286","author":"CM Devlin","year":"2011","unstructured":"Devlin CM, Lahm T, Hubbard WC, Van Demark M, Wang KC, Wu X, Bielawska A, Obeid LM, Ivan M, Petrache I (2011) Dihydroceramide-based response to hypoxia. J Biol Chem 286(44):38069\u201338078. https:\/\/doi.org\/10.1074\/jbc.M111.297994","journal-title":"J Biol Chem"},{"issue":"8","key":"2984_CR56","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1194\/jlr.M065920","volume":"57","author":"L Cai","year":"2016","unstructured":"Cai L, Oyeniran C, Biswas DD, Allegood J, Milstien S, Kordula T, Maceyka M, Spiegel S (2016) ORMDL proteins regulate ceramide levels during sterile inflammation. J Lipid Res 57(8):1412\u20131422. https:\/\/doi.org\/10.1194\/jlr.M065920","journal-title":"J Lipid Res"},{"issue":"8","key":"2984_CR57","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1194\/jlr.M020941","volume":"53","author":"W Ruangsiriluk","year":"2012","unstructured":"Ruangsiriluk W, Grosskurth SE, Ziemek D, Kuhn M, des Etages SG, Francone OL (2012) Silencing of enzymes involved in ceramide biosynthesis causes distinct global alterations of lipid homeostasis and gene expression. J Lipid Res 53(8):1459\u20131471. https:\/\/doi.org\/10.1194\/jlr.M020941","journal-title":"J Lipid Res"},{"issue":"14","key":"2984_CR58","doi-asserted-by":"publisher","first-page":"18095","DOI":"10.18632\/oncotarget.7741","volume":"7","author":"G Grammatikos","year":"2016","unstructured":"Grammatikos G, Schoell N, Ferreir\u00f3s N, Bon D, Herrmann E, Farnik H, K\u00f6berle V, Piiper A, Zeuzem S, Kronenberger B, Waidmann O, Pfeilschifter J (2016) Serum sphingolipidomic analyses reveal an upregulation of C16-ceramide and sphingosine-1-phosphate in hepatocellular carcinoma. Oncotarget 7(14):18095\u201318105. https:\/\/doi.org\/10.18632\/oncotarget.7741","journal-title":"Oncotarget"},{"issue":"7","key":"2984_CR59","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1016\/j.bbalip.2014.04.007","volume":"1841","author":"G Grammatikos","year":"2014","unstructured":"Grammatikos G, M\u00fchle C, Ferreiros N, Schroeter S, Bogdanou D, Schwalm S, Hintereder G, Kornhuber J, Zeuzem S, Sarrazin C, Pfeilschifter J (2014) Serum acid sphingomyelinase is upregulated in chronic hepatitis C infection and non alcoholic fatty liver disease. Biochim Biophys Acta Mol Cell Biol Lipids 1841(7):1012\u20131020. https:\/\/doi.org\/10.1016\/j.bbalip.2014.04.007","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"issue":"5","key":"2984_CR60","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1007\/s12975-016-0477-3","volume":"7","author":"N Sun","year":"2016","unstructured":"Sun N, Keep RF, Hua Y, Xi G (2016) Critical role of the sphingolipid pathway in stroke: a review of current utility and potential therapeutic targets. Transl Stroke Res 7(5):420\u2013438. https:\/\/doi.org\/10.1007\/s12975-016-0477-3","journal-title":"Transl Stroke Res"},{"issue":"2","key":"2984_CR61","doi-asserted-by":"publisher","first-page":"259","DOI":"10.3233\/JAD-2011-110405","volume":"27","author":"MM Mielke","year":"2011","unstructured":"Mielke MM, Haughey NJ, Bandaru VV, Weinberg DD, Darby E, Zaidi N, Pavlik V, Doody RS, Lyketsos CG (2011) Plasma sphingomyelins are associated with cognitive progression in Alzheimer\u2019s disease. J Alzheimers Dis 27(2):259\u2013269. https:\/\/doi.org\/10.3233\/JAD-2011-110405","journal-title":"J Alzheimers Dis"},{"key":"2984_CR62","doi-asserted-by":"publisher","first-page":"698","DOI":"10.3389\/fnins.2017.00698","volume":"11","author":"A Pardo Di","year":"2017","unstructured":"Di Pardo A, Basit A, Armirotti A, Amico E, Castaldo S, Pepe G, Marracino F, Buttari F, Digilio AF, Maglione V (2017) De novo synthesis of sphingolipids is defective in experimental models of Huntington\u2019s disease. Front Neurosci 11:698. https:\/\/doi.org\/10.3389\/fnins.2017.00698","journal-title":"Front Neurosci"},{"issue":"11","key":"2984_CR63","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.1038\/ejhg.2016.54","volume":"24","author":"F Matesanz","year":"2016","unstructured":"Matesanz F, Fedetz M, Barrionuevo C, Karaky M, Catal\u00e1-Rabasa A, Potenciano V, Bello-Morales R, L\u00f3pez-Guerrero J-A, Alcina A (2016) A splice variant in the ACSL5 gene relates migraine with fatty acid activation in mitochondria. Eur J Hum Genet 24(11):1572\u20131577. https:\/\/doi.org\/10.1038\/ejhg.2016.54","journal-title":"Eur J Hum Genet"},{"issue":"3","key":"2984_CR64","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s11095-017-2312-2","volume":"35","author":"L Ord\u00f3\u00f1ez-Guti\u00e9rrez","year":"2018","unstructured":"Ord\u00f3\u00f1ez-Guti\u00e9rrez L, Benito-Cuesta I, Abad JL, Casas J, F\u00e1brias G, Wandosell F (2018) Dihydroceramide desaturase 1 inhibitors reduce amyloid-\u03b2 levels in primary neurons from an Alzheimer\u2019s disease transgenic model. Pharm Res 35(3):49. https:\/\/doi.org\/10.1007\/s11095-017-2312-2","journal-title":"Pharm Res"},{"issue":"12","key":"2984_CR65","doi-asserted-by":"publisher","first-page":"2135","DOI":"10.1016\/j.biocel.2012.08.025","volume":"44","author":"V Gagliostro","year":"2012","unstructured":"Gagliostro V, Casas J, Caretti A, Abad JL, Tagliavacca L, Ghidoni R, Fabrias G, Signorelli P (2012) Dihydroceramide delays cell cycle G1\/S transition via activation of ER stress and induction of autophagy. Int J Biochem Cell Biol 44(12):2135\u20132143. https:\/\/doi.org\/10.1016\/j.biocel.2012.08.025","journal-title":"Int J Biochem Cell Biol"},{"issue":"2","key":"2984_CR66","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.bbagen.2016.11.033","volume":"1861","author":"M Casasampere","year":"2017","unstructured":"Casasampere M, Ord\u00f3\u00f1ez YF, Casas J, Fabrias G (2017) Dihydroceramide desaturase inhibitors induce autophagy via dihydroceramide-dependent and independent mechanisms. Biochim Biophys Acta Gen Subj 1861(2):264\u2013275. https:\/\/doi.org\/10.1016\/j.bbagen.2016.11.033","journal-title":"Biochim Biophys Acta Gen Subj"},{"issue":"2","key":"2984_CR67","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1007\/s13300-016-0167-x","volume":"7","author":"JD Schofield","year":"2016","unstructured":"Schofield JD, Liu Y, Rao-Balakrishna P, Malik RA, Soran H (2016) Diabetes dyslipidemia. Diabetes Ther 7(2):203\u2013219. https:\/\/doi.org\/10.1007\/s13300-016-0167-x","journal-title":"Diabetes Ther"},{"key":"2984_CR68","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1038\/ncpendmet1066","volume":"5","author":"AD Mooradian","year":"2009","unstructured":"Mooradian AD (2009) Dyslipidemia in type 2 diabetes mellitus. Nat Clin Pract Endocrinol Metab 5:150. https:\/\/doi.org\/10.1038\/ncpendmet1066","journal-title":"Nat Clin Pract Endocrinol Metab"},{"issue":"19","key":"2984_CR69","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1556\/650.2016.30441","volume":"157","author":"L Mark","year":"2016","unstructured":"Mark L, Dani G (2016) Diabetic dyslipidaemia and the atherosclerosis. Orv Hetil 157(19):746\u2013752. https:\/\/doi.org\/10.1556\/650.2016.30441","journal-title":"Orv Hetil"},{"issue":"6","key":"2984_CR70","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1007\/s00395-010-0112-5","volume":"105","author":"KJ Sattler","year":"2010","unstructured":"Sattler KJ, Elbasan S, Keul P, Elter-Schulz M, Bode C, Graler MH, Brocker-Preuss M, Budde T, Erbel R, Heusch G, Levkau B (2010) Sphingosine 1-phosphate levels in plasma and HDL are altered in coronary artery disease. Basic Res Cardiol 105(6):821\u2013832. https:\/\/doi.org\/10.1007\/s00395-010-0112-5","journal-title":"Basic Res Cardiol"},{"key":"2984_CR71","doi-asserted-by":"publisher","unstructured":"Reali F, Morine MJ, Kahramano\u011fullar\u0131 O, Raichur S, Schneider H-C, Crowther D, Priami C (2017) Mechanistic interplay between ceramide and insulin resistance. Sci Rep 7:41231. https:\/\/doi.org\/10.1038\/srep41231 . https:\/\/www.nature.com\/articles\/srep41231#supplementary-information","DOI":"10.1038\/srep41231"},{"issue":"35","key":"2984_CR72","doi-asserted-by":"publisher","first-page":"36608","DOI":"10.1074\/jbc.M406499200","volume":"279","author":"S Stratford","year":"2004","unstructured":"Stratford S, Hoehn KL, Liu F, Summers SA (2004) Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of AKT\/protein kinase B. J Biol Chem 279(35):36608\u201336615. https:\/\/doi.org\/10.1074\/jbc.M406499200","journal-title":"J Biol Chem"},{"issue":"4","key":"2984_CR73","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1016\/j.cmet.2014.08.002","volume":"20","author":"SM Turpin","year":"2014","unstructured":"Turpin SM, Nicholls HT, Willmes DM, Mourier A, Brodesser S, Wunderlich CM, Mauer J, Xu E, Hammerschmidt P, Bronneke HS, Trifunovic A, LoSasso G, Wunderlich FT, Kornfeld JW, Bluher M, Kronke M, Bruning JC (2014) Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance. Cell Metab 20(4):678\u2013686. https:\/\/doi.org\/10.1016\/j.cmet.2014.08.002","journal-title":"Cell Metab"},{"issue":"4","key":"2984_CR74","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/j.cmet.2014.09.015","volume":"20","author":"S Raichur","year":"2014","unstructured":"Raichur S, Wang ST, Chan PW, Li Y, Ching J, Chaurasia B, Dogra S, Ohman MK, Takeda K, Sugii S, Pewzner-Jung Y, Futerman AH, Summers SA (2014) CerS2 haploinsufficiency inhibits beta-oxidation and confers susceptibility to diet-induced steatohepatitis and insulin resistance. Cell Metab 20(4):687\u2013695. https:\/\/doi.org\/10.1016\/j.cmet.2014.09.015","journal-title":"Cell Metab"},{"issue":"4","key":"2984_CR75","doi-asserted-by":"publisher","first-page":"778","DOI":"10.2337\/db12-0073","volume":"61","author":"R Taylor","year":"2012","unstructured":"Taylor R (2012) Insulin resistance and type 2 diabetes. Diabetes 61(4):778","journal-title":"Diabetes"},{"issue":"2","key":"2984_CR76","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1007\/s00125-017-4462-5","volume":"61","author":"A Szpigel","year":"2018","unstructured":"Szpigel A, Hainault I, Carlier A, Venteclef N, Batto A-F, Hajduch E, Bernard C, Ktorza A, Gautier J-F, Ferr\u00e9 P, Bourron O, Foufelle F (2018) Lipid environment induces ER stress, TXNIP expression and inflammation in immune cells of individuals with type 2 diabetes. Diabetologia 61(2):399\u2013412. https:\/\/doi.org\/10.1007\/s00125-017-4462-5","journal-title":"Diabetologia"},{"issue":"11","key":"2984_CR77","doi-asserted-by":"publisher","first-page":"5231","DOI":"10.1210\/en.2012-1368","volume":"153","author":"SA Patel","year":"2012","unstructured":"Patel SA, Hoehn KL, Lawrence RT, Sawbridge L, Talbot NA, Tomsig JL, Turner N, Cooney GJ, Whitehead JP, Kraegen EW, Cleasby ME (2012) Overexpression of the adiponectin receptor AdipoR1 in rat skeletal muscle amplifies local insulin sensitivity. Endocrinology 153(11):5231\u20135246. https:\/\/doi.org\/10.1210\/en.2012-1368","journal-title":"Endocrinology"},{"key":"2984_CR78","doi-asserted-by":"publisher","first-page":"e2226","DOI":"10.1038\/cddis.2016.132","volume":"7","author":"Q Qu","year":"2016","unstructured":"Qu Q, Zeng F, Liu X, Wang QJ, Deng F (2016) Fatty acid oxidation and carnitine palmitoyltransferase I: emerging therapeutic targets in cancer. Cell Death Dis 7:e2226. https:\/\/doi.org\/10.1038\/cddis.2016.132","journal-title":"Cell Death Dis"},{"key":"2984_CR79","doi-asserted-by":"publisher","first-page":"211","DOI":"10.3389\/fendo.2018.00211","volume":"9","author":"M Williams","year":"2018","unstructured":"Williams M, Caino MC (2018) Mitochondrial dynamics in Type 2 diabetes and cancer. Front Endocrinol 9:211. https:\/\/doi.org\/10.3389\/fendo.2018.00211","journal-title":"Front Endocrinol"},{"issue":"11","key":"2984_CR80","doi-asserted-by":"publisher","first-page":"2353","DOI":"10.1128\/MCB.00226-13","volume":"33","author":"MM Siddique","year":"2013","unstructured":"Siddique MM, Li Y, Wang L, Ching J, Mal M, Ilkayeva O, Wu YJ, Bay BH, Summers SA (2013) Ablation of dihydroceramide desaturase 1, a therapeutic target for the treatment of metabolic diseases, simultaneously stimulates anabolic and catabolic signaling. Mol Cell Biol 33(11):2353\u20132369. https:\/\/doi.org\/10.1128\/MCB.00226-13","journal-title":"Mol Cell Biol"},{"issue":"2","key":"2984_CR81","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1128\/MCB.05603-11","volume":"32","author":"H-F Jheng","year":"2012","unstructured":"Jheng H-F, Tsai P-J, Guo S-M, Kuo L-H, Chang C-S, Su I-J, Chang C-R, Tsai Y-S (2012) Mitochondrial fission contributes to mitochondrial dysfunction and insulin resistance in skeletal muscle. Mol Cell Biol 32(2):309","journal-title":"Mol Cell Biol"},{"issue":"8","key":"2984_CR82","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.1016\/j.yexcr.2008.02.002","volume":"314","author":"WL Lai","year":"2008","unstructured":"Lai WL, Wong NS (2008) The PERK\/eIF2 alpha signaling pathway of unfolded protein response is essential for N-(4-hydroxyphenyl)retinamide (4HPR)-induced cytotoxicity in cancer cells. Exp Cell Res 314(8):1667\u20131682. https:\/\/doi.org\/10.1016\/j.yexcr.2008.02.002","journal-title":"Exp Cell Res"},{"key":"2984_CR83","doi-asserted-by":"publisher","first-page":"e00222","DOI":"10.1128\/MCB.00222-18","volume":"38","author":"M Alsanafi","year":"2018","unstructured":"Alsanafi M, Kelly SL, Jubair K, McNaughton M, Tate RJ, Merrill AH, Pyne S, Pyne NJ (2018) Native and polyubiquitinated forms of dihydroceramide desaturase are differentially linked to human embryonic kidney cell survival. Mol Cell Biol 38:e00222","journal-title":"Mol Cell Biol"},{"issue":"1","key":"2984_CR84","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/1475-2891-13-17","volume":"13","author":"B Grygiel-G\u00f3rniak","year":"2014","unstructured":"Grygiel-G\u00f3rniak B (2014) Peroxisome proliferator-activated receptors and their ligands: nutritional and clinical implications\u2014a review. Nutr J 13(1):17. https:\/\/doi.org\/10.1186\/1475-2891-13-17","journal-title":"Nutr J"},{"issue":"4","key":"2984_CR85","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1007\/s00125-015-3850-y","volume":"59","author":"BC Bergman","year":"2016","unstructured":"Bergman BC, Brozinick JT, Strauss A, Bacon S, Kerege A, Bui HH, Sanders P, Siddall P, Wei T, Thomas MK, Kuo MS, Perreault L (2016) Muscle sphingolipids during rest and exercise: a C18:0 signature for insulin resistance in humans. Diabetologia 59(4):785\u2013798. https:\/\/doi.org\/10.1007\/s00125-015-3850-y","journal-title":"Diabetologia"},{"issue":"2","key":"2984_CR86","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1002\/jcp.22745","volume":"227","author":"AU Blachnio-Zabielska","year":"2012","unstructured":"Blachnio-Zabielska AU, Pulka M, Baranowski M, Nikolajuk A, Zabielski P, Gorska M, Gorski J (2012) Ceramide metabolism is affected by obesity and diabetes in human adipose tissue. J Cell Physiol 227(2):550\u2013557. https:\/\/doi.org\/10.1002\/jcp.22745","journal-title":"J Cell Physiol"},{"key":"2984_CR87","unstructured":"Curran JE, Weir, Jacquelyn M., Bellis, Claire., Carless, Melanie A., Jowett, Jeremy B., Mahaney, Michael C., Dyer, Thomas D., Goring, Harald H., Comuzzie, Anthony G., Almasy, Laura., Meikle, Peter J., Blangero, John. (2011) Genetic analysis of lipidomic profiles influencing diabetes risk in Mexican Americans. Paper presented at the American Diabetes Association, 71st Scientific Sessions"},{"issue":"1","key":"2984_CR88","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/s12944-016-0234-3","volume":"15","author":"M Mamtani","year":"2016","unstructured":"Mamtani M, Kulkarni H, Wong G, Weir JM, Barlow CK, Dyer TD, Almasy L, Mahaney MC, Comuzzie AG, Glahn DC, Magliano DJ, Zimmet P, Shaw J, Williams-Blangero S, Duggirala R, Blangero J, Meikle PJ, Curran JE (2016) Lipidomic risk score independently and cost-effectively predicts risk of future type 2 diabetes: results from diverse cohorts. Lipids Health Dis 15(1):67. https:\/\/doi.org\/10.1186\/s12944-016-0234-3","journal-title":"Lipids Health Dis"},{"key":"2984_CR89","doi-asserted-by":"crossref","unstructured":"Benjamin EJ, Virani SS, Callaway CW, Chang AR, Cheng S, Chiuve SE, Cushman M, Delling FN, Deo R, de Ferranti SD, Ferguson JF, Fornage M, Gillespie C, Isasi CR, Jim\u00e9nez MC, Jordan LC, Judd SE, Lackland D, Lichtman JH, Lisabeth L, Liu S, Longenecker CT, Lutsey PL, Matchar DB, Matsushita K, Mussolino ME, Nasir K, O\u2019Flaherty M, Palaniappan LP, Pandey DK, Reeves MJ, Ritchey MD, Rodriguez CJ, Roth GA, Rosamond WD, Sampson UKA, Satou GM, Shah SH, Spartano NL, Tirschwell DL, Tsao CW, Voeks JH, Willey JZ, Wilkins JT, Wu JHY, Alger HM, Wong SS, Muntner P (2018) Heart disease and stroke statistics\u20142018 update: a report from the American Heart Association. Circulation 137(12):e67\u2013e492","DOI":"10.1161\/CIR.0000000000000558"},{"issue":"11 Suppl","key":"2984_CR90","doi-asserted-by":"publisher","first-page":"S624","DOI":"10.1097\/00005768-199911001-00022","volume":"31","author":"RH Fagard","year":"1999","unstructured":"Fagard RH (1999) Physical activity in the prevention and treatment of hypertension in the obese. Med Sci Sports Exerc 31(11 Suppl):S624\u2013S630","journal-title":"Med Sci Sports Exerc"},{"issue":"10","key":"2984_CR91","doi-asserted-by":"publisher","first-page":"1632","DOI":"10.1111\/j.1532-5415.2004.52454.x","volume":"52","author":"DH Paterson","year":"2004","unstructured":"Paterson DH, Govindasamy D, Vidmar M, Cunningham DA, Koval JJ (2004) Longitudinal study of determinants of dependence in an elderly population. J Am Geriatr Soc 52(10):1632\u20131638. https:\/\/doi.org\/10.1111\/j.1532-5415.2004.52454.x","journal-title":"J Am Geriatr Soc"},{"issue":"9","key":"2984_CR92","doi-asserted-by":"publisher","first-page":"1612","DOI":"10.2337\/diacare.25.9.1612","volume":"25","author":"DE Laaksonen","year":"2002","unstructured":"Laaksonen DE, Lakka HM, Salonen JT, Niskanen LK, Rauramaa R, Lakka TA (2002) Low levels of leisure-time physical activity and cardiorespiratory fitness predict development of the metabolic syndrome. Diabetes Care 25(9):1612\u20131618","journal-title":"Diabetes Care"},{"issue":"6","key":"2984_CR93","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1089\/dna.2013.1993","volume":"32","author":"R Azzam","year":"2013","unstructured":"Azzam R, Hariri F, El-Hachem N, Kamar A, Dbaibo G, Nemer G, Bitar F (2013) Regulation of de novo ceramide synthesis: the role of dihydroceramide desaturase and transcriptional factors NFATC and Hand2 in the hypoxic mouse heart. DNA Cell Biol 32(6):310\u2013319. https:\/\/doi.org\/10.1089\/dna.2013.1993","journal-title":"DNA Cell Biol"},{"key":"2984_CR94","doi-asserted-by":"publisher","unstructured":"Dirkx E, Gladka MM, Philippen LE, Armand A-S, Kinet V, Leptidis S, el Azzouzi H, Salic K, Bourajjaj M, da Silva GJJ, Olieslagers S, van der Nagel R, de Weger R, Bitsch N, Kisters N, Seyen S, Morikawa Y, Chanoine C, Heymans S, Volders PGA, Thum T, Dimmeler S, Cserjesi P, Eschenhagen T, da Costa Martins PA, De Windt LJ (2013) Nfat and miR-25 cooperate to reactivate the transcription factor Hand2 in heart failure. Nat Cell Biol 15:1282. https:\/\/doi.org\/10.1038\/ncb2866 . https:\/\/www.nature.com\/articles\/ncb2866#supplementary-information","DOI":"10.1038\/ncb2866"},{"key":"2984_CR95","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.mad.2017.08.015","volume":"167","author":"V Mello-Coelho de","year":"2017","unstructured":"de Mello-Coelho V, Cutler RG, Bunbury A, Tammara A, Mattson MP, Taub DD (2017) Age-associated alterations in the levels of cytotoxic lipid molecular species and oxidative stress in the murine thymus are reduced by growth hormone treatment. Mech Ageing Dev 167:46\u201355. https:\/\/doi.org\/10.1016\/j.mad.2017.08.015","journal-title":"Mech Ageing Dev"},{"issue":"23","key":"2984_CR96","doi-asserted-by":"publisher","first-page":"17221","DOI":"10.1074\/jbc.R000005200","volume":"275","author":"DA Brown","year":"2000","unstructured":"Brown DA, London E (2000) Structure and function of sphingolipid- and cholesterol-rich membrane rafts. J Biol Chem 275(23):17221\u201317224. https:\/\/doi.org\/10.1074\/jbc.R000005200","journal-title":"J Biol Chem"},{"key":"2984_CR97","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.redox.2016.12.002","volume":"11","author":"D Gonz\u00e1lez-Pe\u00f1a","year":"2017","unstructured":"Gonz\u00e1lez-Pe\u00f1a D, Checa A, de Ancos B, Wheelock CE, S\u00e1nchez-Moreno C (2017) New insights into the effects of onion consumption on lipid mediators using a diet-induced model of hypercholesterolemia. Redox Biol 11:205\u2013212. https:\/\/doi.org\/10.1016\/j.redox.2016.12.002","journal-title":"Redox Biol"},{"issue":"1","key":"2984_CR98","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1080\/17584299.2017.1319787","volume":"12","author":"AB Reiss","year":"2017","unstructured":"Reiss AB, Siegart NM, De Leon J (2017) Interleukin-6 in atherosclerosis: atherogenic or atheroprotective? Clin Lipidol 12(1):14\u201323. https:\/\/doi.org\/10.1080\/17584299.2017.1319787","journal-title":"Clin Lipidol"},{"issue":"1","key":"2984_CR99","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1186\/s12933-016-0439-9","volume":"15","author":"T-T Chang","year":"2016","unstructured":"Chang T-T, Chen J-W (2016) Emerging role of chemokine CC motif ligand 4 related mechanisms in diabetes mellitus and cardiovascular disease: friends or foes? Cardiovasc Diabetol 15(1):117. https:\/\/doi.org\/10.1186\/s12933-016-0439-9","journal-title":"Cardiovasc Diabetol"},{"issue":"8","key":"2984_CR100","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1007\/s11306-016-1086-6","volume":"12","author":"L Fang","year":"2016","unstructured":"Fang L, Mundra PA, Fan F, Galvin A, Weir JM, Wong G, Chin-Dusting J, Cicuttini F, Meikle P, Dart AM (2016) Plasma lipidomic profiling in patients with rheumatoid arthritis. Metabolomics 12(8):136. https:\/\/doi.org\/10.1007\/s11306-016-1086-6","journal-title":"Metabolomics"},{"issue":"4, Supplement)","key":"2984_CR101","doi-asserted-by":"publisher","first-page":"S93","DOI":"10.1016\/j.healun.2017.01.235","volume":"36","author":"B Fine","year":"2017","unstructured":"Fine B, Marx A, Topkara V, Gomez EA, Vunjak-Novakovic G, Colombo P (2017) (223)\u2014An integrated analysis of metabolomics after left ventricular assist device implantation. J Heart Lung Transplant 36(4, Supplement)):S93. https:\/\/doi.org\/10.1016\/j.healun.2017.01.235","journal-title":"J Heart Lung Transplant"},{"key":"2984_CR102","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1155\/2018\/9281946","volume":"2018","author":"A Liu","year":"2018","unstructured":"Liu A, Chu Y-J, Wang X, Yu R, Jiang H, Li Y, Zhou H, Gong L-L, Yang W-Q, Ju J (2018) Serum metabolomics study based on LC-MS and antihypertensive effect of uncaria on spontaneously hypertensive rats. Evid Based Complement Altern Med 2018:11. https:\/\/doi.org\/10.1155\/2018\/9281946","journal-title":"Evid Based Complement Altern Med"},{"issue":"Suppl 3","key":"2984_CR103","first-page":"A17320","volume":"132","author":"R Ji","year":"2015","unstructured":"Ji R, Chang JY, Liao X, Zhang X, Kennel P, Castillero E, Brunjes D, Akashi H, Homma S, Goldberg I, Schulze PC (2015) Abstract 17320: inhibition of ceramide synthesis preserves cardiac function and increases survival in doxorubicin-induced cardiomyopathy. Circulation 132(Suppl 3):A17320","journal-title":"Circulation"},{"key":"2984_CR104","doi-asserted-by":"publisher","unstructured":"Sharma A, Sung B, Veerappan A, Silver RB, Kim B, Worgall TS, Worgall S (2017) Decreased Sphingolipid Synthesis Enhances Rhinovirus-Triggered Airway Hyperreactivity. In: A36. Host defense against viral infection. American Thoracic Society International Conference Abstracts, American Thoracic Society, pp A1381\u2013A1381. https:\/\/doi.org\/10.1164\/ajrccm-conference.2017.195.1_meetingabstracts.a1381","DOI":"10.1164\/ajrccm-conference.2017.195.1_meetingabstracts.a1381"},{"key":"2984_CR105","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19040991","author":"VT Mucke","year":"2018","unstructured":"Mucke VT, Gerharz J, Jakobi K, Thomas D, Ferreiros Bouzas N, Mucke MM, Trotschler S, Weiler N, Welker MW, Zeuzem S, Pfeilschifter J, Grammatikos G (2018) Low serum levels of (dihydro-)ceramides reflect liver graft dysfunction in a real-world cohort of patients post liver transplantation. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms19040991","journal-title":"Int J Mol Sci"},{"key":"2984_CR106","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-1318","author":"M Apostolopoulou","year":"2018","unstructured":"Apostolopoulou M, Gordillo R, Koliaki C, Gancheva S, Jelenik T, De Filippo E, Herder C, Markgraf D, Jankowiak F, Esposito I, Schlensak M, Scherer PE, Roden M (2018) Specific hepatic sphingolipids relate to insulin resistance, oxidative stress, and inflammation in nonalcoholic steatohepatitis. Diabetes Care. https:\/\/doi.org\/10.2337\/dc17-1318","journal-title":"Diabetes Care"},{"issue":"9","key":"2984_CR107","doi-asserted-by":"publisher","first-page":"3929","DOI":"10.1074\/jbc.M116.756460","volume":"292","author":"A Alexaki","year":"2017","unstructured":"Alexaki A, Clarke BA, Gavrilova O, Ma Y, Zhu H, Ma X, Xu L, Tuymetova G, Larman BC, Allende ML, Dunn TM, Proia RL (2017) De novo sphingolipid biosynthesis is required for adipocyte survival and metabolic homeostasis. J Biol Chem 292(9):3929\u20133939. https:\/\/doi.org\/10.1074\/jbc.M116.756460","journal-title":"J Biol Chem"},{"key":"2984_CR108","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.jep.2015.05.010","volume":"170","author":"L Qu","year":"2015","unstructured":"Qu L, Qu F, Jia Z, Wang C, Wu C, Zhang J (2015) Integrated targeted sphingolipidomics and transcriptomics reveal abnormal sphingolipid metabolism as a novel mechanism of the hepatotoxicity and nephrotoxicity of triptolide. J Ethnopharmacol 170:28\u201338. https:\/\/doi.org\/10.1016\/j.jep.2015.05.010","journal-title":"J Ethnopharmacol"},{"issue":"1","key":"2984_CR109","doi-asserted-by":"publisher","first-page":"37","DOI":"10.2174\/1389200216666151103120338","volume":"17","author":"F Li","year":"2015","unstructured":"Li F, Zhang N (2015) Ceramide: therapeutic potential in combination therapy for cancer treatment. Curr Drug Metab 17(1):37\u201351","journal-title":"Curr Drug Metab"},{"issue":"15","key":"2984_CR110","doi-asserted-by":"publisher","first-page":"6313","DOI":"10.1158\/0008-5472.CAN-10-0999","volume":"70","author":"MA Park","year":"2010","unstructured":"Park MA, Mitchell C, Zhang G, Yacoub A, Allegood J, H\u00e4ussinger D, Reinehr R, Larner A, Spiegel S, Fisher PB, Voelkel-Johnson C, Ogretmen B, Grant S, Dent P (2010) Vorinostat and sorafenib increase CD95 activation in gastrointestinal tumor cells through a Ca2+-de novo ceramide-PP2A-ROS dependent signaling pathway. Can Res 70(15):6313\u20136324. https:\/\/doi.org\/10.1158\/0008-5472.CAN-10-0999","journal-title":"Can Res"},{"issue":"11","key":"2984_CR111","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1007\/s00277-011-1212-5","volume":"90","author":"EB Gencer","year":"2011","unstructured":"Gencer EB, Ural AU, Avcu F, Baran Y (2011) A novel mechanism of dasatinib-induced apoptosis in chronic myeloid leukemia; ceramide synthase and ceramide clearance genes. Ann Hematol 90(11):1265\u20131275. https:\/\/doi.org\/10.1007\/s00277-011-1212-5","journal-title":"Ann Hematol"},{"issue":"3","key":"2984_CR112","doi-asserted-by":"publisher","first-page":"144","DOI":"10.5483\/BMBRep.2017.50.3.197","volume":"50","author":"HJ Maeng","year":"2017","unstructured":"Maeng HJ, Song J-H, Kim G-T, Song Y-J, Lee K, Kim J-Y, Park T-S (2017) Celecoxib-mediated activation of endoplasmic reticulum stress induces de novo ceramide biosynthesis and apoptosis in hepatoma HepG2 cells. BMB Rep 50(3):144\u2013149. https:\/\/doi.org\/10.5483\/bmbrep.2017.50.3.197","journal-title":"BMB Rep"},{"issue":"2","key":"2984_CR113","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.canlet.2009.03.020","volume":"282","author":"P Signorelli","year":"2009","unstructured":"Signorelli P, Munoz-Olaya JM, Gagliostro V, Casas J, Ghidoni R, Fabri\u00e0s G (2009) Dihydroceramide intracellular increase in response to resveratrol treatment mediates autophagy in gastric cancer cells. Cancer Lett 282(2):238\u2013243. https:\/\/doi.org\/10.1016\/j.canlet.2009.03.020","journal-title":"Cancer Lett"},{"issue":"9","key":"2984_CR114","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.1097\/j.pain.0000000000000965","volume":"158","author":"SA Grenald","year":"2017","unstructured":"Grenald SA, Doyle TM, Zhang H, Slosky LM, Chen Z, Largent-Milnes TM, Spiegel S, Vanderah TW, Salvemini D (2017) Targeting the S1P\/S1PR1 axis mitigates cancer-induced bone pain and neuroinflammation. Pain 158(9):1733\u20131742. https:\/\/doi.org\/10.1097\/j.pain.0000000000000965","journal-title":"Pain"},{"issue":"9","key":"2984_CR115","doi-asserted-by":"publisher","first-page":"e74768","DOI":"10.1371\/journal.pone.0074768","volume":"8","author":"MW Holliday Jr","year":"2013","unstructured":"Holliday MW Jr, Cox SB, Kang MH, Maurer BJ (2013) C22:0- and C24:0-dihydroceramides confer mixed cytotoxicity in T-Cell acute lymphoblastic leukemia cell lines. PLoS One 8(9):e74768. https:\/\/doi.org\/10.1371\/journal.pone.0074768","journal-title":"PLoS One"},{"issue":"5","key":"2984_CR116","doi-asserted-by":"publisher","first-page":"2422","DOI":"10.1074\/jbc.M115.666909","volume":"291","author":"N Realini","year":"2016","unstructured":"Realini N, Palese F, Pizzirani D, Pontis S, Basit A, Bach A, Ganesan A, Piomelli D (2016) Acid ceramidase in melanoma: expression, localization, and effects of pharmacological inhibition. J Biol Chem 291(5):2422\u20132434. https:\/\/doi.org\/10.1074\/jbc.M115.666909","journal-title":"J Biol Chem"},{"issue":"1","key":"2984_CR117","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.prostaglandins.2010.03.002","volume":"92","author":"P Knapp","year":"2010","unstructured":"Knapp P, Baranowski M, Knapp M, Zabielski P, B\u0142achnio-Zabielska AU, G\u00f3rski J (2010) Altered sphingolipid metabolism in human endometrial cancer. Prostaglandins Other Lipid Mediat 92(1):62\u201366. https:\/\/doi.org\/10.1016\/j.prostaglandins.2010.03.002","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"2984_CR118","doi-asserted-by":"publisher","first-page":"172897","DOI":"10.1155\/2012\/172897","volume":"2012","author":"M Cazzaniga","year":"2012","unstructured":"Cazzaniga M, Varricchio C, Montefrancesco C, Feroce I, Guerrieri-Gonzaga A (2012) Fenretinide (4-HPR): a preventive chance for women at genetic and familial risk? J Biomed Biotechnol 2012:172897. https:\/\/doi.org\/10.1155\/2012\/172897","journal-title":"J Biomed Biotechnol"},{"issue":"28","key":"2984_CR119","doi-asserted-by":"publisher","first-page":"24754","DOI":"10.1074\/jbc.M111.250779","volume":"286","author":"M Rahmaniyan","year":"2011","unstructured":"Rahmaniyan M, Curley RW, Obeid LM, Hannun YA, Kraveka JM (2011) Identification of dihydroceramide desaturase as a direct in vitro target for fenretinide. J Biol Chem 286(28):24754\u201324764. https:\/\/doi.org\/10.1074\/jbc.M111.250779","journal-title":"J Biol Chem"},{"issue":"24","key":"2984_CR120","doi-asserted-by":"publisher","first-page":"18594","DOI":"10.1074\/jbc.M109.072801","volume":"285","author":"G Illuzzi","year":"2010","unstructured":"Illuzzi G, Bernacchioni C, Aureli M, Prioni S, Frera G, Donati C, Valsecchi M, Chigorno V, Bruni P, Sonnino S, Prinetti A (2010) Sphingosine kinase mediates resistance to the synthetic retinoid N-(4-hydroxyphenyl)retinamide in human ovarian cancer cells. J Biol Chem 285(24):18594\u201318602. https:\/\/doi.org\/10.1074\/jbc.M109.072801","journal-title":"J Biol Chem"},{"key":"2984_CR121","doi-asserted-by":"publisher","first-page":"e1425","DOI":"10.1038\/cddis.2014.384","volume":"5","author":"J Noack","year":"2014","unstructured":"Noack J, Choi J, Richter K, Kopp-Schneider A, Regnier-Vigouroux A (2014) A sphingosine kinase inhibitor combined with temozolomide induces glioblastoma cell death through accumulation of dihydrosphingosine and dihydroceramide, endoplasmic reticulum stress and autophagy. Cell Death Dis 5:e1425. https:\/\/doi.org\/10.1038\/cddis.2014.384","journal-title":"Cell Death Dis"},{"issue":"7","key":"2984_CR122","doi-asserted-by":"publisher","first-page":"1832","DOI":"10.1194\/jlr.M004010","volume":"51","author":"M Valsecchi","year":"2010","unstructured":"Valsecchi M, Aureli M, Mauri L, Illuzzi G, Chigorno V, Prinetti A, Sonnino S (2010) Sphingolipidomics of A2780 human ovarian carcinoma cells treated with synthetic retinoids. J Lipid Res 51(7):1832\u20131840. https:\/\/doi.org\/10.1194\/jlr.M004010","journal-title":"J Lipid Res"},{"issue":"9","key":"2984_CR123","doi-asserted-by":"publisher","first-page":"2967","DOI":"10.1158\/1535-7163.MCT-08-0549","volume":"7","author":"H Wang","year":"2008","unstructured":"Wang H, Maurer BJ, Liu YY, Wang E, Allegood JC, Kelly S, Symolon H, Liu Y, Merrill AH Jr, Gouaze-Andersson V, Yu JY, Giuliano AE, Cabot MC (2008) N-(4-Hydroxyphenyl)retinamide increases dihydroceramide and synergizes with dimethylsphingosine to enhance cancer cell killing. Mol Cancer Ther 7(9):2967\u20132976. https:\/\/doi.org\/10.1158\/1535-7163.MCT-08-0549","journal-title":"Mol Cancer Ther"},{"issue":"2","key":"2984_CR124","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1042\/BJ20091589","volume":"427","author":"J Idkowiak-Baldys","year":"2010","unstructured":"Idkowiak-Baldys J, Apraiz A, Li L, Rahmaniyan M, Clarke CJ, Kraveka JM, Asumendi A, Hannun YA (2010) Dihydroceramide desaturase activity is modulated by oxidative stress. Biochem J 427(2):265\u2013274. https:\/\/doi.org\/10.1042\/BJ20091589","journal-title":"Biochem J"},{"issue":"12","key":"2984_CR125","doi-asserted-by":"publisher","first-page":"2744","DOI":"10.1158\/1535-7163.MCT-15-0279","volume":"14","author":"H Venant","year":"2015","unstructured":"Venant H, Rahmaniyan M, Jones EE, Lu P, Lilly MB, Garrett-Mayer E, Drake RR, Kraveka JM, Smith CD, Voelkel-Johnson C (2015) The sphingosine kinase 2 inhibitor ABC294640 reduces the growth of prostate cancer cells and results in accumulation of dihydroceramides in vitro and in vivo. Mol Cancer Ther 14(12):2744\u20132752. https:\/\/doi.org\/10.1158\/1535-7163.MCT-15-0279","journal-title":"Mol Cancer Ther"},{"issue":"5102","key":"2984_CR126","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.1126\/science.8456305","volume":"259","author":"LM Obeid","year":"1993","unstructured":"Obeid LM, Linardic CM, Karolak LA, Hannun YA (1993) Programmed cell death induced by ceramide. Science 259(5102):1769","journal-title":"Science"},{"issue":"42","key":"2984_CR127","doi-asserted-by":"publisher","first-page":"25356","DOI":"10.1074\/jbc.M115.658658","volume":"290","author":"MJ Hernandez-Corbacho","year":"2015","unstructured":"Hernandez-Corbacho MJ, Canals D, Adada MM, Liu M, Senkal CE, Yi JK, Mao C, Luberto C, Hannun YA, Obeid LM (2015) Tumor necrosis factor-alpha (TNFalpha)-induced ceramide generation via ceramide synthases regulates loss of focal adhesion kinase (FAK) and programmed cell death. J Biol Chem 290(42):25356\u201325373. https:\/\/doi.org\/10.1074\/jbc.M115.658658","journal-title":"J Biol Chem"},{"issue":"9","key":"2984_CR128","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1038\/s41388-017-0046-6","volume":"37","author":"SS Singh","year":"2018","unstructured":"Singh SS, Vats S, Chia AY, Tan TZ, Deng S, Ong MS, Arfuso F, Yap CT, Goh BC, Sethi G, Huang RY, Shen HM, Manjithaya R, Kumar AP (2018) Dual role of autophagy in hallmarks of cancer. Oncogene 37(9):1142\u20131158. https:\/\/doi.org\/10.1038\/s41388-017-0046-6","journal-title":"Oncogene"},{"issue":"2","key":"2984_CR129","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1139\/o2012-001","volume":"90","author":"A Apraiz","year":"2012","unstructured":"Apraiz A, Idkowiak-Baldys J, Nieto-Rementer\u00eda N, Boyano MD, Hannun YA, Asumendi A (2012) Dihydroceramide accumulation and reactive oxygen species are distinct and nonessential events in 4-HPR-mediated leukemia cell death. Biochem Cell Biol 90(2):209\u2013223. https:\/\/doi.org\/10.1139\/o2012-001","journal-title":"Biochem Cell Biol"},{"issue":"12","key":"2984_CR130","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1038\/onc.2016.334","volume":"36","author":"C McNair","year":"2017","unstructured":"McNair C, Urbanucci A, Comstock CES, Augello MA, Goodwin JF, Launchbury R, Zhao SG, Schiewer MJ, Ertel A, Karnes J, Davicioni E, Wang L, Wang Q, Mills IG, Feng FY, Li W, Carroll JS, Knudsen KE (2017) Cell cycle-coupled expansion of AR activity promotes cancer progression. Oncogene 36(12):1655\u20131668. https:\/\/doi.org\/10.1038\/onc.2016.334","journal-title":"Oncogene"},{"issue":"10","key":"2984_CR131","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1002\/mc.20533","volume":"48","author":"W Zhou","year":"2009","unstructured":"Zhou W, Ye X-L, Sun Z-J, Ji X-D, Chen H-X, Xie D (2009) Overexpression of degenerative spermatocyte homolog 1 up-regulates the expression of cyclin D1 and enhances metastatic efficiency in esophageal carcinoma Eca109 cells. Mol Carcinog 48(10):886\u2013894. https:\/\/doi.org\/10.1002\/mc.20533","journal-title":"Mol Carcinog"},{"issue":"Supplement C","key":"2984_CR132","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.jphotobiol.2016.02.040","volume":"159","author":"NB Boppana","year":"2016","unstructured":"Boppana NB, DeLor JS, Van Buren E, Bielawska A, Bielawski J, Pierce JS, Korbelik M, Separovic D (2016) Enhanced apoptotic cancer cell killing after Foscan photodynamic therapy combined with fenretinide via de novo sphingolipid biosynthesis pathway. J Photochem Photobiol B Biol 159(Supplement C):191\u2013195. https:\/\/doi.org\/10.1016\/j.jphotobiol.2016.02.040","journal-title":"J Photochem Photobiol B Biol"},{"issue":"1","key":"2984_CR133","first-page":"77","volume":"33","author":"P Breen","year":"2013","unstructured":"Breen P, Joseph N, Thompson K, Kraveka JM, Gudz TI, Li LI, Rahmaniyan M, Bielawski J, Pierce JS, Van Buren E, Bhatti G, Separovic D (2013) Dihydroceramide desaturase knockdown impacts sphingolipids and apoptosis after photodamage in human head and neck squamous carcinoma cells. Anticancer Res 33(1):77\u201384","journal-title":"Anticancer Res"},{"issue":"4","key":"2984_CR134","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1038\/sj.bjc.6604896","volume":"100","author":"D Separovic","year":"2009","unstructured":"Separovic D, Bielawski J, Pierce JS, Merchant S, Tarca AL, Ogretmen B, Korbelik M (2009) Increased tumour dihydroceramide production after Photofrin-PDT alone and improved tumour response after the combination with the ceramide analogue LCL29. Evidence from mouse squamous cell carcinomas. Br J Cancer 100(4):626\u2013632. https:\/\/doi.org\/10.1038\/sj.bjc.6604896","journal-title":"Br J Cancer"},{"issue":"7","key":"2984_CR135","first-page":"2479","volume":"32","author":"D Separovic","year":"2012","unstructured":"Separovic D, Breen P, Joseph N, Bielawski J, Pierce JS, Van Buren E, Gudz TI (2012) siRNA-mediated down-regulation of ceramide synthase 1 leads to apoptotic resistance in human head and neck squamous carcinoma cells after photodynamic therapy. Anticancer Res 32(7):2479\u20132485","journal-title":"Anticancer Res"},{"issue":"3","key":"2984_CR136","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1002\/ijc.26054","volume":"130","author":"Q Jiang","year":"2012","unstructured":"Jiang Q, Rao X, Kim CY, Freiser H, Zhang Q, Jiang Z, Li G (2012) Gamma-tocotrienol induces apoptosis and autophagy in prostate cancer cells by increasing intracellular dihydrosphingosine and dihydroceramide. Int J Cancer 130(3):685\u2013693. https:\/\/doi.org\/10.1002\/ijc.26054","journal-title":"Int J Cancer"},{"issue":"7","key":"2984_CR137","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.2174\/18715206113139990116","volume":"13","author":"PW Sylvester","year":"2013","unstructured":"Sylvester PW, Ayoub NM (2013) Tocotrienols target PI3K\/Akt signaling in anti-breast cancer therapy. Anticancer Agents Med Chem 13(7):1039\u20131047","journal-title":"Anticancer Agents Med Chem"},{"issue":"1","key":"2984_CR138","doi-asserted-by":"publisher","first-page":"126","DOI":"10.4049\/jimmunol.1403149","volume":"195","author":"Y Wang","year":"2015","unstructured":"Wang Y, Park NY, Jang Y, Ma A, Jiang Q (2015) Vitamin E gamma-tocotrienol inhibits cytokine-stimulated NF-kappaB activation by induction of anti-inflammatory A20 via stress adaptive response due to modulation of sphingolipids. J Immunol 195(1):126\u2013133. https:\/\/doi.org\/10.4049\/jimmunol.1403149","journal-title":"J Immunol"},{"key":"2984_CR139","doi-asserted-by":"publisher","first-page":"e972","DOI":"10.1038\/cddis.2013.494","volume":"4","author":"A Dorronsoro","year":"2013","unstructured":"Dorronsoro A, Lang V, Jakobsson E, Ferrin I, Salcedo JM, Fern\u00e1ndez-Rueda J, Fechter K, Rodriguez MS, Trigueros C (2013) Identification of the NF-\u03baB inhibitor A20 as a key regulator for human adipogenesis. Cell Death Dis 4:e972. https:\/\/doi.org\/10.1038\/cddis.2013.494","journal-title":"Cell Death Dis"},{"issue":"1","key":"2984_CR140","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1194\/jlr.M009142","volume":"52","author":"TD Mullen","year":"2011","unstructured":"Mullen TD, Spassieva S, Jenkins RW, Kitatani K, Bielawski J, Hannun YA, Obeid LM (2011) Selective knockdown of ceramide synthases reveals complex interregulation of sphingolipid metabolism. J Lipid Res 52(1):68\u201377. https:\/\/doi.org\/10.1194\/jlr.M009142","journal-title":"J Lipid Res"},{"issue":"14","key":"2984_CR141","doi-asserted-by":"publisher","first-page":"6959","DOI":"10.1073\/pnas.93.14.6959","volume":"93","author":"A Huwiler","year":"1996","unstructured":"Huwiler A, Brunner J, Hummel R, Vervoordeldonk M, Stabel S, van den Bosch H, Pfeilschifter J (1996) Ceramide-binding and activation defines protein kinase c-Raf as a ceramide-activated protein kinase. Proc Natl Acad Sci USA 93(14):6959\u20136963","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2\u20133","key":"2984_CR142","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.bbalip.2003.08.010","volume":"1636","author":"A Huwiler","year":"2004","unstructured":"Huwiler A, Xin C, Brust AK, Briner VA, Pfeilschifter J (2004) Differential binding of ceramide to MEKK1 in glomerular endothelial and mesangial cells. Biochim Biophys Acta 1636(2\u20133):159\u2013168. https:\/\/doi.org\/10.1016\/j.bbalip.2003.08.010","journal-title":"Biochim Biophys Acta"},{"issue":"19","key":"2984_CR143","doi-asserted-by":"publisher","first-page":"5527","DOI":"10.1021\/la500622f","volume":"30","author":"B Skolova","year":"2014","unstructured":"Skolova B, Jandovska K, Pullmannova P, Tesar O, Roh J, Hrabalek A, Vavrova K (2014) The role of the trans double bond in skin barrier sphingolipids: permeability and infrared spectroscopic study of model ceramide and dihydroceramide membranes. Langmuir 30(19):5527\u20135535. https:\/\/doi.org\/10.1021\/la500622f","journal-title":"Langmuir"},{"issue":"2","key":"2984_CR144","doi-asserted-by":"publisher","first-page":"268.e266","DOI":"10.1016\/j.jaad.2017.03.016","volume":"77","author":"M Dany","year":"2017","unstructured":"Dany M, Elston D (2017) Gene expression of sphingolipid metabolism pathways is altered in hidradenitis suppurativa. J Am Acad Dermatol 77(2):268.e266\u2013273.e266. https:\/\/doi.org\/10.1016\/j.jaad.2017.03.016","journal-title":"J Am Acad Dermatol"},{"issue":"9","key":"2984_CR145","doi-asserted-by":"publisher","first-page":"2753","DOI":"10.1194\/jlr.M007716","volume":"51","author":"JM Deeley","year":"2010","unstructured":"Deeley JM, Hankin JA, Friedrich MG, Murphy RC, Truscott RJW, Mitchell TW, Blanksby SJ (2010) Sphingolipid distribution changes with age in the human lens. J Lipid Res 51(9):2753\u20132760. https:\/\/doi.org\/10.1194\/jlr.M007716","journal-title":"J Lipid Res"},{"key":"2984_CR146","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.taap.2016.02.018","volume":"298","author":"NM Gardner","year":"2016","unstructured":"Gardner NM, Riley RT, Showker JL, Voss KA, Sachs AJ, Maddox JR, Gelineau-van Waes JB (2016) Elevated nuclear sphingoid base-1-phosphates and decreased histone deacetylase activity after fumonisin B1 treatment in mouse embryonic fibroblasts. Toxicol Appl Pharmacol 298:56\u201365. https:\/\/doi.org\/10.1016\/j.taap.2016.02.018","journal-title":"Toxicol Appl Pharmacol"},{"issue":"1","key":"2984_CR147","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1083\/jcb.114.1.155","volume":"114","author":"H Zhang","year":"1991","unstructured":"Zhang H, Desai NN, Olivera A, Seki T, Brooker G, Spiegel S (1991) Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation. J Cell Biol 114(1):155\u2013167","journal-title":"J Cell Biol"},{"issue":"6446","key":"2984_CR148","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1038\/365557a0","volume":"365","author":"A Olivera","year":"1993","unstructured":"Olivera A, Spiegel S (1993) Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens. Nature 365(6446):557\u2013560. https:\/\/doi.org\/10.1038\/365557a0","journal-title":"Nature"},{"issue":"2","key":"2984_CR149","doi-asserted-by":"publisher","first-page":"503","DOI":"10.3233\/JAD-171054","volume":"63","author":"TA Couttas","year":"2018","unstructured":"Couttas TA, Kain N, Tran C, Chatterton Z, Kwok JB, Don AS (2018) Age-dependent changes to sphingolipid balance in the human hippocampus are gender-specific and may sensitize to neurodegeneration. J Alzheimers Dis 63(2):503\u2013514. https:\/\/doi.org\/10.3233\/JAD-171054","journal-title":"J Alzheimers Dis"},{"issue":"2","key":"2984_CR150","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1016\/j.neuropharm.2011.10.005","volume":"62","author":"P Callihan","year":"2012","unstructured":"Callihan P, Zitomer NC, Stoeling MV, Kennedy PC, Lynch KR, Riley RT, Hooks SB (2012) Distinct generation, pharmacology, and distribution of sphingosine 1-phosphate and dihydrosphingosine 1-phosphate in human neural progenitor cells. Neuropharmacology 62(2):988\u2013996. https:\/\/doi.org\/10.1016\/j.neuropharm.2011.10.005","journal-title":"Neuropharmacology"},{"issue":"4","key":"2984_CR151","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/S0898-6568(02)00119-5","volume":"15","author":"A Niedernberg","year":"2003","unstructured":"Niedernberg A, Tunaru S, Blaukat A, Ardati A, Kostenis E (2003) Sphingosine 1-phosphate and dioleoylphosphatidic acid are low affinity agonists for the orphan receptor GPR63. Cell Signal 15(4):435\u2013446","journal-title":"Cell Signal"},{"key":"2984_CR152","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.ejps.2017.05.003","volume":"105","author":"W Lin","year":"2017","unstructured":"Lin W, Zhang J, Liu Y, Wu R, Yang H, Hu X, Ling X (2017) Studies on diagnostic biomarkers and therapeutic mechanism of Alzheimer\u2019s disease through metabolomics and hippocampal proteomics. Eur J Pharm Sci 105:119\u2013126. https:\/\/doi.org\/10.1016\/j.ejps.2017.05.003","journal-title":"Eur J Pharm Sci"},{"issue":"2","key":"2984_CR153","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1007\/s13148-011-0025-7","volume":"2","author":"SG Gray","year":"2011","unstructured":"Gray SG (2011) Targeting Huntington\u2019s disease through histone deacetylases. Clin Epigenet 2(2):257\u2013277. https:\/\/doi.org\/10.1007\/s13148-011-0025-7","journal-title":"Clin Epigenet"},{"key":"2984_CR154","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.phrs.2015.08.002","volume":"100","author":"S Sharma","year":"2015","unstructured":"Sharma S, Taliyan R (2015) Transcriptional dysregulation in Huntington\u2019s disease: the role of histone deacetylases. Pharmacol Res 100:157\u2013169. https:\/\/doi.org\/10.1016\/j.phrs.2015.08.002","journal-title":"Pharmacol Res"},{"issue":"18","key":"2984_CR155","doi-asserted-by":"publisher","first-page":"6952","DOI":"10.1523\/JNEUROSCI.17-18-06952.1997","volume":"17","author":"LC Edsall","year":"1997","unstructured":"Edsall LC, Pirianov GG, Spiegel S (1997) Involvement of sphingosine 1-phosphate in nerve growth factor-mediated neuronal survival and differentiation. J Neurosci 17(18):6952\u20136960","journal-title":"J Neurosci"},{"issue":"28","key":"2984_CR156","doi-asserted-by":"publisher","first-page":"19593","DOI":"10.1074\/jbc.M802417200","volume":"283","author":"S Bu","year":"2008","unstructured":"Bu S, Kapanadze B, Hsu T, Trojanowska M (2008) Opposite effects of dihydrosphingosine 1-phosphate and sphingosine 1-phosphate on transforming growth factor-beta\/Smad signaling are mediated through the PTEN\/PPM1A-dependent pathway. J Biol Chem 283(28):19593\u201319602. https:\/\/doi.org\/10.1074\/jbc.M802417200","journal-title":"J Biol Chem"},{"issue":"6","key":"2984_CR157","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.1124\/mol.104.003681","volume":"66","author":"G Triola","year":"2004","unstructured":"Triola G, Fabrias G, Dragusin M, Niederhausen L, Broere R, Llebaria A, van Echten-Deckert G (2004) Specificity of the dihydroceramide desaturase inhibitor N-[(1R,2S)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopropenyl)ethyl]octanami de (GT11) in primary cultured cerebellar neurons. Mol Pharmacol 66(6):1671\u20131678. https:\/\/doi.org\/10.1124\/mol.104.003681","journal-title":"Mol Pharmacol"},{"issue":"10","key":"2984_CR158","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1002\/bdra.23074","volume":"94","author":"J Gelineau-van Waes","year":"2012","unstructured":"Gelineau-van Waes J, Rainey MA, Maddox JR, Voss KA, Sachs AJ, Gardner NM, Wilberding JD, Riley RT (2012) Increased sphingoid base-1-phosphates and failure of neural tube closure after exposure to fumonisin or FTY720. Birth Defects Res A Clin Mol Teratol 94(10):790\u2013803. https:\/\/doi.org\/10.1002\/bdra.23074","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"issue":"3","key":"2984_CR159","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1111\/j.1748-1716.2011.02322.x","volume":"203","author":"M Baranowski","year":"2011","unstructured":"Baranowski M, Charmas M, Dlugolecka B, Gorski J (2011) Exercise increases plasma levels of sphingoid base-1 phosphates in humans. Acta Physiol (Oxf) 203(3):373\u2013380. https:\/\/doi.org\/10.1111\/j.1748-1716.2011.02322.x","journal-title":"Acta Physiol (Oxf)"},{"issue":"2","key":"2984_CR160","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1123\/ijsnem.2013-0093","volume":"24","author":"M Baranowski","year":"2014","unstructured":"Baranowski M, Gorski J, Klapcinska B, Waskiewicz Z, Sadowska-Krepa E (2014) Ultramarathon run markedly reduces plasma sphingosine-1-phosphate concentration. Int J Sport Nutr Exerc Metab 24(2):148\u2013156. https:\/\/doi.org\/10.1123\/ijsnem.2013-0093","journal-title":"Int J Sport Nutr Exerc Metab"},{"issue":"5","key":"2984_CR161","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1007\/s00421-014-3080-x","volume":"115","author":"M Baranowski","year":"2015","unstructured":"Baranowski M, B\u0142achnio-Zabielska AU, Charmas M, Helge JW, Dela F, Ksi\u0105\u017cek M, D\u0142ugo\u0142\u0119cka B, Klusiewicz A, Chabowski A, G\u00f3rski J (2015) Exercise increases sphingoid base-1-phosphate levels in human blood and skeletal muscle in a time- and intensity-dependent manner. Eur J Appl Physiol 115(5):993\u20131003. https:\/\/doi.org\/10.1007\/s00421-014-3080-x","journal-title":"Eur J Appl Physiol"},{"issue":"6","key":"2984_CR162","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1007\/s00395-012-0294-0","volume":"107","author":"M Knapp","year":"2012","unstructured":"Knapp M, Zendzian-Piotrowska M, Blachnio-Zabielska A, Zabielski P, Kurek K, Gorski J (2012) Myocardial infarction differentially alters sphingolipid levels in plasma, erythrocytes and platelets of the rat. Basic Res Cardiol 107(6):294. https:\/\/doi.org\/10.1007\/s00395-012-0294-0","journal-title":"Basic Res Cardiol"},{"issue":"1","key":"2984_CR163","doi-asserted-by":"publisher","first-page":"e122","DOI":"10.1016\/j.atherosclerosis.2015.04.425","volume":"241","author":"J G\u00f3rski","year":"2015","unstructured":"G\u00f3rski J, Baranowski M, W\u00f3jcik B, Chabowski A (2015) Effect of atrial pacing on the level of bioactive sphingolipids in the heart ventricles of the rat. Atherosclerosis 241(1):e122\u2013e123. https:\/\/doi.org\/10.1016\/j.atherosclerosis.2015.04.425","journal-title":"Atherosclerosis"},{"key":"2984_CR164","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.prostaglandins.2013.10.001","volume":"106","author":"M Knapp","year":"2013","unstructured":"Knapp M, Lisowska A, Zabielski P, Musia\u0142 W, Baranowski M (2013) Sustained decrease in plasma sphingosine-1-phosphate concentration and its accumulation in blood cells in acute myocardial infarction. Prostaglandins Other Lipid Mediat 106:53\u201361. https:\/\/doi.org\/10.1016\/j.prostaglandins.2013.10.001","journal-title":"Prostaglandins Other Lipid Mediat"},{"issue":"9","key":"2984_CR165","first-page":"CR490","volume":"15","author":"M Knapp","year":"2009","unstructured":"Knapp M, Baranowski M, Czarnowski D, Lisowska A, Zabielski P, Gorski J, Musial W (2009) Plasma sphingosine-1-phosphate concentration is reduced in patients with myocardial infarction. Med Sci Monit 15(9):CR490\u2013CR493","journal-title":"Med Sci Monit"},{"issue":"7","key":"2984_CR166","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1194\/jlr.R059543","volume":"56","author":"M Ksi\u0105\u017cek","year":"2015","unstructured":"Ksi\u0105\u017cek M, Chaci\u0144ska M, Chabowski A, Baranowski M (2015) Sources, metabolism, and regulation of circulating sphingosine-1-phosphate. J Lipid Res 56(7):1271\u20131281. https:\/\/doi.org\/10.1194\/jlr.R059543","journal-title":"J Lipid Res"},{"key":"2984_CR167","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1186\/1476-511X-10-70","volume":"10","author":"KM Argraves","year":"2011","unstructured":"Argraves KM, Sethi AA, Gazzolo PJ, Wilkerson BA, Remaley AT, Tybjaerg-Hansen A, Nordestgaard BG, Yeatts SD, Nicholas KS, Barth JL, Argraves WS (2011) S1P, dihydro-S1P and C24:1-ceramide levels in the HDL-containing fraction of serum inversely correlate with occurrence of ischemic heart disease. Lipids Health Dis 10:70. https:\/\/doi.org\/10.1186\/1476-511X-10-70","journal-title":"Lipids Health Dis"},{"key":"2984_CR168","doi-asserted-by":"publisher","first-page":"243","DOI":"10.3389\/fphar.2015.00243","volume":"6","author":"B Levkau","year":"2015","unstructured":"Levkau B (2015) HDL-S1P: cardiovascular functions, disease-associated alterations, and therapeutic applications. Front Pharmacol 6:243. https:\/\/doi.org\/10.3389\/fphar.2015.00243","journal-title":"Front Pharmacol"},{"issue":"1","key":"2984_CR169","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1093\/jb\/mvi100","volume":"138","author":"S Aoki","year":"2005","unstructured":"Aoki S, Yatomi Y, Ohta M, Osada M, Kazama F, Satoh K, Nakahara K, Ozaki Y (2005) Sphingosine 1-phosphate-related metabolism in the blood vessel. J Biochem 138(1):47\u201355. https:\/\/doi.org\/10.1093\/jb\/mvi100","journal-title":"J Biochem"},{"issue":"12","key":"2984_CR170","doi-asserted-by":"publisher","first-page":"2704","DOI":"10.1111\/j.1538-7836.2006.02241.x","volume":"4","author":"F Dahm","year":"2006","unstructured":"Dahm F, Nocito A, Bielawska A, Lang KS, Georgiev P, Asmis LM, Bielawski J, Madon J, Hannun YA, Clavien PA (2006) Distribution and dynamic changes of sphingolipids in blood in response to platelet activation. J Thromb Haemost 4(12):2704\u20132709. https:\/\/doi.org\/10.1111\/j.1538-7836.2006.02241.x","journal-title":"J Thromb Haemost"},{"key":"2984_CR171","doi-asserted-by":"publisher","first-page":"12","DOI":"10.4172\/2155-9880.1000482","volume":"7","author":"M Knapp","year":"2016","unstructured":"Knapp M, Lisowska A (2016) Blood bioactive sphingolipids and activity of acid sphingomyelinase in patients with multivessel coronary artery disease. J Clin Exp Cardiol 7:12. https:\/\/doi.org\/10.4172\/2155-9880.1000482","journal-title":"J Clin Exp Cardiol"},{"key":"2984_CR172","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/1476-511X-12-20","volume":"12","author":"Y Ono","year":"2013","unstructured":"Ono Y, Kurano M, Ohkawa R, Yokota H, Igarashi K, Aoki J, Tozuka M, Yatomi Y (2013) Sphingosine 1-phosphate release from platelets during clot formation: close correlation between platelet count and serum sphingosine 1-phosphate concentration. Lipids Health Dis 12:20. https:\/\/doi.org\/10.1186\/1476-511X-12-20","journal-title":"Lipids Health Dis"},{"issue":"4","key":"2984_CR173","doi-asserted-by":"publisher","first-page":"e0175118","DOI":"10.1371\/journal.pone.0175118","volume":"12","author":"A Dobierzewska","year":"2017","unstructured":"Dobierzewska A, Soman S, Illanes SE, Morris AJ (2017) Plasma cross-gestational sphingolipidomic analyses reveal potential first trimester biomarkers of preeclampsia. PLoS One 12(4):e0175118. https:\/\/doi.org\/10.1371\/journal.pone.0175118","journal-title":"PLoS One"},{"issue":"suppl_1","key":"2984_CR174","doi-asserted-by":"publisher","first-page":"P2417","DOI":"10.1093\/eurheartj\/eht308.P2417","volume":"34","author":"T Sugiura","year":"2013","unstructured":"Sugiura T, Dohi Y, Yamashita S, Ohte N, Ito S, Sanagawa A, Iwaki S, Ohkawa R, Yatomi Y, Fujii S (2013) Circulating microRNA-126 as a potential biomarker for recovery from smoking-related vascular endothelial damage. Eur Heart J 34(suppl_1):P2417. https:\/\/doi.org\/10.1093\/eurheartj\/eht308.p2417","journal-title":"Eur Heart J"},{"issue":"3","key":"2984_CR175","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1161\/hh0302.104455","volume":"90","author":"Y Ryu","year":"2002","unstructured":"Ryu Y, Takuwa N, Sugimoto N, Sakurada S, Usui S, Okamoto H, Matsui O, Takuwa Y (2002) Sphingosine-1-phosphate, a platelet-derived lysophospholipid mediator, negatively regulates cellular rac activity and cell migration in vascular smooth muscle cells. Circ Res 90(3):325","journal-title":"Circ Res"},{"issue":"1","key":"2984_CR176","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1096\/fj.05-4646fje","volume":"20","author":"S Bu","year":"2006","unstructured":"Bu S, Yamanaka M, Pei H, Bielawska A, Bielawski J, Hannun YA, Obeid L, Trojanowska M (2006) Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1\/2-Ets1 pathway in human fibroblasts. FASEB J 20(1):184\u2013186. https:\/\/doi.org\/10.1096\/fj.05-4646fje","journal-title":"FASEB J"},{"issue":"7","key":"2984_CR177","doi-asserted-by":"publisher","first-page":"2117","DOI":"10.1002\/art.27463","volume":"62","author":"S Bu","year":"2010","unstructured":"Bu S, Asano Y, Bujor A, Highland K, Hant F, Trojanowska M (2010) Dihydrosphingosine-1 phosphate has a potent anti-fibrotic effect in Scleroderma fibroblasts via normalization of PTEN levels. Arthritis Rheum 62(7):2117\u20132126. https:\/\/doi.org\/10.1002\/art.27463","journal-title":"Arthritis Rheum"},{"issue":"1\u20132","key":"2984_CR178","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000446703","volume":"53","author":"JM Ruddy","year":"2016","unstructured":"Ruddy JM, Ikonomidis JS, Jones JA (2016) Multidimensional contribution of matrix metalloproteinases to atherosclerotic plaque vulnerability: multiple mechanisms of inhibition to promote stability. J Vasc Res 53(1\u20132):1\u201316. https:\/\/doi.org\/10.1159\/000446703","journal-title":"J Vasc Res"},{"issue":"18","key":"2984_CR179","doi-asserted-by":"publisher","first-page":"1668","DOI":"10.1016\/S0195-668X(03)00385-3","volume":"24","author":"S Ye","year":"2003","unstructured":"Ye S, Gale CR, Martyn CN (2003) Variation in the matrix metalloproteinase-1 gene and risk of coronary heart disease. Eur Heart J 24(18):1668\u20131671","journal-title":"Eur Heart J"},{"issue":"9","key":"2984_CR180","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.lfs.2013.07.017","volume":"93","author":"IA Gorshkova","year":"2013","unstructured":"Gorshkova IA, Wang H, Orbelyan GA, Goya J, Natarajan V, Beiser DG, Vanden Hoek TL, Berdyshev EV (2013) Inhibition of sphingosine-1-phosphate lyase rescues sphingosine kinase-1-knockout phenotype following murine cardiac arrest. Life Sci 93(9):359\u2013366. https:\/\/doi.org\/10.1016\/j.lfs.2013.07.017","journal-title":"Life Sci"},{"issue":"47","key":"2984_CR181","doi-asserted-by":"publisher","first-page":"46832","DOI":"10.1074\/jbc.M306577200","volume":"278","author":"N Igarashi","year":"2003","unstructured":"Igarashi N, Okada T, Hayashi S, Fujita T, Jahangeer S, S-i Nakamura (2003) Sphingosine kinase 2 is a nuclear protein and inhibits DNA synthesis. J Biol Chem 278(47):46832\u201346839","journal-title":"J Biol Chem"},{"issue":"2","key":"2984_CR182","doi-asserted-by":"publisher","first-page":"274","DOI":"10.2478\/ams-2013-0021","volume":"58","author":"M Knapp","year":"2013","unstructured":"Knapp M, Lisowska A, Knapp P, Baranowski M (2013) Dose-dependent effect of aspirin on the level of sphingolipids in human blood. Adv Med Sci 58(2):274\u2013281. https:\/\/doi.org\/10.2478\/ams-2013-0021","journal-title":"Adv Med Sci"},{"key":"2984_CR183","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s40348-015-0025-3","volume":"2","author":"JG Ono","year":"2015","unstructured":"Ono JG, Worgall TS, Worgall S (2015) Airway reactivity and sphingolipids\u2014implications for childhood asthma. Mol Cell Pediatr 2:13. https:\/\/doi.org\/10.1186\/s40348-015-0025-3","journal-title":"Mol Cell Pediatr"},{"key":"2984_CR184","doi-asserted-by":"crossref","unstructured":"Miller M, Tam AB, Mueller JL, Rosenthal P, Beppu A, Gordillo R, McGeough MD, Vuong C, Doherty TA, Hoffman HM, Niwa M, Broide DH (2017) Cutting edge: targeting epithelial ORMDL3 increases, rather than reduces, airway responsiveness and is associated with increased sphingosine-1-phosphate. J Immunol","DOI":"10.4049\/jimmunol.1601848"},{"issue":"2, Supplement","key":"2984_CR185","doi-asserted-by":"publisher","first-page":"AB113","DOI":"10.1016\/j.jaci.2017.12.360","volume":"141","author":"K Kowal","year":"2018","unstructured":"Kowal K, Zebrowska E, Chabowski A (2018) Plasma concentration of selected sphingolipids correlates with lung function parameters in house dust mite allergic patients. J Allergy Clin Immunol 141(2, Supplement):AB113. https:\/\/doi.org\/10.1016\/j.jaci.2017.12.360","journal-title":"J Allergy Clin Immunol"},{"issue":"4","key":"2984_CR186","doi-asserted-by":"publisher","first-page":"1035 e1036","DOI":"10.1016\/j.jaci.2015.02.031","volume":"136","author":"C Oyeniran","year":"2015","unstructured":"Oyeniran C, Sturgill JL, Hait NC, Huang WC, Avni D, Maceyka M, Newton J, Allegood JC, Montpetit A, Conrad DH, Milstien S, Spiegel S (2015) Aberrant ORM (yeast)-like protein isoform 3 (ORMDL3) expression dysregulates ceramide homeostasis in cells and ceramide exacerbates allergic asthma in mice. J Allergy Clin Immunol 136(4):1035 e1036\u20131046 e1036. https:\/\/doi.org\/10.1016\/j.jaci.2015.02.031","journal-title":"J Allergy Clin Immunol"},{"issue":"10","key":"2984_CR187","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.1016\/j.cellsig.2006.01.018","volume":"18","author":"EV Berdyshev","year":"2006","unstructured":"Berdyshev EV, Gorshkova IA, Usatyuk P, Zhao Y, Saatian B, Hubbard W, Natarajan V (2006) De novo biosynthesis of dihydrosphingosine-1-phosphate by sphingosine kinase 1 in mammalian cells. Cell Signal 18(10):1779\u20131792. https:\/\/doi.org\/10.1016\/j.cellsig.2006.01.018","journal-title":"Cell Signal"},{"issue":"38","key":"2984_CR188","doi-asserted-by":"publisher","first-page":"35258","DOI":"10.1074\/jbc.M105442200","volume":"276","author":"LC Boujaoude","year":"2001","unstructured":"Boujaoude LC, Bradshaw-Wilder C, Mao C, Cohn J, Ogretmen B, Hannun YA, Obeid LM (2001) Cystic fibrosis transmembrane regulator regulates uptake of sphingoid base phosphates and lysophosphatidic acid: modulation of cellular activity of sphingosine 1-phosphate. J Biol Chem 276(38):35258\u201335264. https:\/\/doi.org\/10.1074\/jbc.M105442200","journal-title":"J Biol Chem"},{"issue":"8","key":"2984_CR189","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1194\/jlr.M026039","volume":"53","author":"I Gorshkova","year":"2012","unstructured":"Gorshkova I, Zhou T, Mathew B, Jacobson JR, Takekoshi D, Bhattacharya P, Smith B, Aydogan B, Weichselbaum RR, Natarajan V, Garcia JG, Berdyshev EV (2012) Inhibition of serine palmitoyltransferase delays the onset of radiation-induced pulmonary fibrosis through the negative regulation of sphingosine kinase-1 expression. J Lipid Res 53(8):1553\u20131568. https:\/\/doi.org\/10.1194\/jlr.M026039","journal-title":"J Lipid Res"},{"issue":"8","key":"2984_CR190","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1038\/labinvest.2010.102","volume":"90","author":"SW Park","year":"2010","unstructured":"Park SW, Kim M, Chen SW, Brown KM, D\u2019Agati VD, Lee HT (2010) Sphinganine-1-phosphate protects kidney and liver after hepatic ischemia and reperfusion in mice through S1P1 receptor activation. Lab Invest 90(8):1209\u20131224. https:\/\/doi.org\/10.1038\/labinvest.2010.102","journal-title":"Lab Invest"},{"issue":"1","key":"2984_CR191","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1097\/SHK.0b013e3181c02c1f","volume":"33","author":"SW Park","year":"2010","unstructured":"Park SW, Kim M, Chen SW, D\u2019Agati VD, Lee HT (2010) Sphinganine-1-phosphate attenuates both hepatic and renal injury induced by hepatic ischemia and reperfusion in mice. Shock 33(1):31\u201342. https:\/\/doi.org\/10.1097\/SHK.0b013e3181c02c1f","journal-title":"Shock"},{"issue":"23","key":"2984_CR192","doi-asserted-by":"publisher","first-page":"2071","DOI":"10.1080\/15287390600746215","volume":"69","author":"DH Kim","year":"2006","unstructured":"Kim DH, Yoo HS, Lee YM, Kie JH, Jang S, Oh S (2006) Elevation of sphinganine 1-phosphate as a predictive biomarker for fumonisin exposure and toxicity in mice. J Toxicol Environ Health A 69(23):2071\u20132082. https:\/\/doi.org\/10.1080\/15287390600746215","journal-title":"J Toxicol Environ Health A"},{"issue":"2","key":"2984_CR193","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/S0300-483X(03)00048-9","volume":"187","author":"NV Gopee","year":"2003","unstructured":"Gopee NV, Sharma RP (2003) Sphingoid bases and their phosphates: transient activation and delayed repression of protein kinase C isoforms and their possible involvement in fumonisin B1 cytotoxicity. Toxicology 187(2):239\u2013250. https:\/\/doi.org\/10.1016\/S0300-483X(03)00048-9","journal-title":"Toxicology"},{"issue":"1","key":"2984_CR194","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.cbi.2005.11.004","volume":"160","author":"D Tardieu","year":"2006","unstructured":"Tardieu D, Tran ST, Auvergne A, Babile R, Benard G, Bailly JD, Guerre P (2006) Effects of fumonisins on liver and kidney sphinganine and the sphinganine to sphingosine ratio during chronic exposure in ducks. Chem Biol Interact 160(1):51\u201360. https:\/\/doi.org\/10.1016\/j.cbi.2005.11.004","journal-title":"Chem Biol Interact"},{"issue":"11","key":"2984_CR195","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.1002\/mnfr.201500499","volume":"59","author":"RT Riley","year":"2015","unstructured":"Riley RT, Torres O, Matute J, Gregory SG, Ashley-Koch AE, Showker JL, Mitchell T, Voss KA, Maddox JR, Gelineau-van Waes JB (2015) Evidence for fumonisin inhibition of ceramide synthase in humans consuming maize-based foods and living in high exposure communities in Guatemala. Mol Nutr Food Res 59(11):2209\u20132224. https:\/\/doi.org\/10.1002\/mnfr.201500499","journal-title":"Mol Nutr Food Res"},{"issue":"5 Pt 2","key":"2984_CR196","doi-asserted-by":"publisher","first-page":"F634","DOI":"10.1152\/ajprenal.1993.265.5.F634","volume":"265","author":"GG Choudhury","year":"1993","unstructured":"Choudhury GG, Biswas P, Grandaliano G, Abboud HE (1993) Involvement of PKC-alpha in PDGF-mediated mitogenic signaling in human mesangial cells. Am J Physiol 265(5 Pt 2):F634\u2013F642. https:\/\/doi.org\/10.1152\/ajprenal.1993.265.5.F634","journal-title":"Am J Physiol"},{"issue":"12","key":"2984_CR197","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1046\/j.1365-2443.2002.00594.x","volume":"7","author":"S Katsuma","year":"2002","unstructured":"Katsuma S, Hada Y, Ueda T, Shiojima S, Hirasawa A, Tanoue A, Takagaki K, Ohgi T, Yano J, Tsujimoto G (2002) Signalling mechanisms in sphingosine 1-phosphate-promoted mesangial cell proliferation. Genes Cells 7(12):1217\u20131230","journal-title":"Genes Cells"},{"issue":"2","key":"2984_CR198","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.bbalip.2012.10.003","volume":"1831","author":"J Veret","year":"2013","unstructured":"Veret J, Coant N, Gorshkova IA, Giussani P, Fradet M, Riccitelli E, Skobeleva A, Goya J, Kassis N, Natarajan V, Portha B, Berdyshev EV, Le Stunff H (2013) Role of palmitate-induced sphingoid base-1-phosphate biosynthesis in INS-1 beta-cell survival. Biochim Biophys Acta 1831(2):251\u2013262. https:\/\/doi.org\/10.1016\/j.bbalip.2012.10.003","journal-title":"Biochim Biophys Acta"},{"issue":"2","key":"2984_CR199","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/S0006-291X(02)02850-4","volume":"300","author":"S Katsuma","year":"2003","unstructured":"Katsuma S, Hada Y, Shiojima S, Hirasawa A, Tanoue A, Takagaki K, Ohgi T, Yano J, Tsujimoto G (2003) Transcriptional profiling of gene expression patterns during sphingosine 1-phosphate-induced mesangial cell proliferation. Biochem Biophys Res Commun 300(2):577\u2013584. https:\/\/doi.org\/10.1016\/S0006-291X(02)02850-4","journal-title":"Biochem Biophys Res Commun"},{"issue":"1\u20132","key":"2984_CR200","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/S0169-328X(00)00262-X","volume":"85","author":"K Sato","year":"2000","unstructured":"Sato K, Ui M, Okajima F (2000) Differential roles of Edg-1 and Edg-5, sphingosine 1-phosphate receptors, in the signaling pathways in C6 glioma cells. Brain Res Mol Brain Res 85(1\u20132):151\u2013160","journal-title":"Brain Res Mol Brain Res"},{"issue":"35","key":"2984_CR201","doi-asserted-by":"publisher","first-page":"32841","DOI":"10.1074\/jbc.M305024200","volume":"278","author":"K Arikawa","year":"2003","unstructured":"Arikawa K, Takuwa N, Yamaguchi H, Sugimoto N, Kitayama J, Nagawa H, Takehara K, Takuwa Y (2003) Ligand-dependent inhibition of B16 melanoma cell migration and invasion via endogenous S1P2 G protein-coupled receptor. Requirement of inhibition of cellular RAC activity. J Biol Chem 278(35):32841\u201332851. https:\/\/doi.org\/10.1074\/jbc.m305024200","journal-title":"J Biol Chem"},{"issue":"3","key":"2984_CR202","doi-asserted-by":"publisher","first-page":"2132","DOI":"10.1021\/nn304862b","volume":"7","author":"BM Barth","year":"2013","unstructured":"Barth BM, Shanmugavelandy SS, Kaiser JM, McGovern C, Altinoglu EI, Haakenson JK, Hengst JA, Gilius EL, Knupp SA, Fox TE, Smith JP, Ritty TM, Adair JH, Kester M (2013) PhotoImmunoNanoTherapy reveals an anticancer role for sphingosine kinase 2 and dihydrosphingosine-1-phosphate. ACS Nano 7(3):2132\u20132144. https:\/\/doi.org\/10.1021\/nn304862b","journal-title":"ACS Nano"},{"issue":"5945","key":"2984_CR203","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1126\/science.1176709","volume":"325","author":"NC Hait","year":"2009","unstructured":"Hait NC, Allegood J, Maceyka M, Strub GM, Harikumar KB, Singh SK, Luo C, Marmorstein R, Kordula T, Milstien S, Spiegel S (2009) Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate. Science 325(5945):1254\u20131257. https:\/\/doi.org\/10.1126\/science.1176709","journal-title":"Science"},{"issue":"12","key":"2984_CR204","doi-asserted-by":"publisher","first-page":"4909","DOI":"10.1182\/blood-2002-09-2962","volume":"101","author":"Y Jin","year":"2003","unstructured":"Jin Y, Knudsen E, Wang L, Bryceson Y, Damaj B, Gessani S, Maghazachi AA (2003) Sphingosine 1-phosphate is a novel inhibitor of T-cell proliferation. Blood 101(12):4909\u20134915. https:\/\/doi.org\/10.1182\/blood-2002-09-2962","journal-title":"Blood"},{"issue":"1 Pt 1","key":"2984_CR205","doi-asserted-by":"publisher","first-page":"L234","DOI":"10.1152\/ajplung.1997.273.1.L234","volume":"273","author":"Y Xu","year":"1997","unstructured":"Xu Y, Stenmark KR, Das M, Walchak SJ, Ruff LJ, Dempsey EC (1997) Pulmonary artery smooth muscle cells from chronically hypoxic neonatal calves retain fetal-like and acquire new growth properties. Am J Physiol 273(1 Pt 1):L234\u2013L245. https:\/\/doi.org\/10.1152\/ajplung.1997.273.1.L234","journal-title":"Am J Physiol"},{"issue":"5 Pt 1","key":"2984_CR206","doi-asserted-by":"publisher","first-page":"L660","DOI":"10.1152\/ajplung.1995.269.5.L660","volume":"269","author":"M Das","year":"1995","unstructured":"Das M, Stenmark KR, Dempsey EC (1995) Enhanced growth of fetal and neonatal pulmonary artery adventitial fibroblasts is dependent on protein kinase C. Am J Physiol 269(5 Pt 1):L660\u2013L667. https:\/\/doi.org\/10.1152\/ajplung.1995.269.5.L660","journal-title":"Am J Physiol"},{"issue":"2","key":"2984_CR207","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1152\/jappl.1991.71.2.410","volume":"71","author":"J Mann","year":"1991","unstructured":"Mann J, Farrukh IS, Michael JR (1991) Mechanisms by which endothelin 1 induces pulmonary vasoconstriction in the rabbit. J Appl Physiol (1985) 71(2):410\u2013416. https:\/\/doi.org\/10.1152\/jappl.1991.71.2.410","journal-title":"J Appl Physiol (1985)"},{"issue":"1","key":"2984_CR208","doi-asserted-by":"publisher","first-page":"2013006","DOI":"10.14252\/foodsafetyfscj.2013006","volume":"1","author":"KA Voss","year":"2013","unstructured":"Voss KA, Riley RT (2013) Fumonisin toxicity and mechanism of action: overview and current perspectives. Food Saf 1(1):2013006. https:\/\/doi.org\/10.14252\/foodsafetyfscj.2013006","journal-title":"Food Saf"},{"issue":"1","key":"2984_CR209","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1093\/toxsci\/kfj198","volume":"92","author":"RT Riley","year":"2006","unstructured":"Riley RT, Voss KA (2006) Differential sensitivity of rat kidney and liver to fumonisin toxicity: organ-specific differences in toxin accumulation and sphingoid base metabolism. Toxicol Sci 92(1):335\u2013345. https:\/\/doi.org\/10.1093\/toxsci\/kfj198","journal-title":"Toxicol Sci"},{"issue":"2","key":"2984_CR210","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1093\/toxsci\/60.2.385","volume":"60","author":"S Mathur","year":"2001","unstructured":"Mathur S, Constable PD, Eppley RM, Waggoner AL, Tumbleson ME, Haschek WM (2001) Fumonisin B(1) is hepatotoxic and nephrotoxic in milk-fed calves. Toxicol Sci 60(2):385\u2013396","journal-title":"Toxicol Sci"},{"issue":"4","key":"2984_CR211","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.3390\/toxins7041253","volume":"7","author":"B Grenier","year":"2015","unstructured":"Grenier B, Schwartz-Zimmermann HE, Caha S, Moll WD, Schatzmayr G, Applegate TJ (2015) Dose-dependent effects on sphingoid bases and cytokines in chickens fed diets prepared with fusarium verticillioides culture material containing fumonisins. Toxins (Basel) 7(4):1253\u20131272. https:\/\/doi.org\/10.3390\/toxins7041253","journal-title":"Toxins (Basel)"},{"issue":"8","key":"2984_CR212","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/S0278-6915(98)00036-2","volume":"36","author":"TF Collins","year":"1998","unstructured":"Collins TF, Sprando RL, Black TN, Shackelford ME, Laborde JB, Hansen DK, Eppley RM, Trucksess MW, Howard PC, Bryant MA, Ruggles DI, Olejnik N, Rorie JI (1998) Effects of fumonisin B1 in pregnant rats. Part 2. Food Chem Toxicol 36(8):673\u2013685. https:\/\/doi.org\/10.1016\/s0278-6915(98)00036-2","journal-title":"Food Chem Toxicol"},{"issue":"1","key":"2984_CR213","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1006\/faat.1997.2380","volume":"40","author":"JB LaBorde","year":"1997","unstructured":"LaBorde JB, Terry KK, Howard PC, Chen JJ, Collins TFX, Shackelford ME, Hansen DK (1997) Lack of embryotoxicity of fumonisin B1in New Zealand White Rabbits. Fundam Appl Toxicol 40(1):120\u2013128. https:\/\/doi.org\/10.1006\/faat.1997.2380","journal-title":"Fundam Appl Toxicol"},{"issue":"4","key":"2984_CR214","doi-asserted-by":"publisher","first-page":"387","DOI":"10.2478\/10004-1254-60-2009-1938","volume":"60","author":"AM Domijan","year":"2009","unstructured":"Domijan AM, Peraica M, Markov K, Fuchs R (2009) Urine ochratoxin a and sphinganine\/sphingosine ratio in residents of the endemic nephropathy area in Croatia. Arh Hig Rada Toksikol 60(4):387\u2013393. https:\/\/doi.org\/10.2478\/10004-1254-60-2009-1938","journal-title":"Arh Hig Rada Toksikol"},{"issue":"6","key":"2984_CR215","doi-asserted-by":"publisher","first-page":"922","DOI":"10.3390\/ijms17060922","volume":"17","author":"G Grammatikos","year":"2016","unstructured":"Grammatikos G, Dietz J, Ferreiros N, Koch A, Dultz G, Bon D, Karakasiliotis I, Lutz T, Knecht G, Gute P, Herrmann E, Zeuzem S, Mavromara P, Sarrazin C, Pfeilschifter J (2016) Persistence of HCV in acutely-infected patients depletes C24-ceramide and upregulates sphingosine and sphinganine serum levels. Int J Mol Sci 17(6):922. https:\/\/doi.org\/10.3390\/ijms17060922","journal-title":"Int J Mol Sci"},{"key":"2984_CR216","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.jep.2018.01.017","volume":"216","author":"S Qiu","year":"2018","unstructured":"Qiu S, Zhang H, Fei Q, Zhu F, Wang J, Jia X, Chen B (2018) Urine and plasma metabolomics study on potential hepatoxic biomarkers identification in rats induced by Gynura segetum. J Ethnopharmacol 216:37\u201346. https:\/\/doi.org\/10.1016\/j.jep.2018.01.017","journal-title":"J Ethnopharmacol"},{"issue":"5","key":"2984_CR217","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1007\/s00216-005-3239-8","volume":"382","author":"D Touboul","year":"2005","unstructured":"Touboul D, Roy S, Germain DP, Baillet A, Brion F, Prognon P, Chaminade P, Laprevote O (2005) Fast fingerprinting by MALDI-TOF mass spectrometry of urinary sediment glycosphingolipids in Fabry disease. Anal Bioanal Chem 382(5):1209\u20131216. https:\/\/doi.org\/10.1007\/s00216-005-3239-8","journal-title":"Anal Bioanal Chem"},{"issue":"2","key":"2984_CR218","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/S0378-4347(01)00041-X","volume":"754","author":"S Ribar","year":"2001","unstructured":"Ribar S, Mesari\u0107 M, Bauman M (2001) High-performance liquid chromatographic determination of sphinganine and sphingosine in serum and urine of subjects from an endemic nephropathy area in Croatia. J Chromatogr B Biomed Sci Appl 754(2):511\u2013519. https:\/\/doi.org\/10.1016\/S0378-4347(01)00041-X","journal-title":"J Chromatogr B Biomed Sci Appl"},{"issue":"8","key":"2984_CR219","doi-asserted-by":"publisher","first-page":"2877","DOI":"10.1021\/acs.jproteome.7b00167","volume":"16","author":"K Cho","year":"2017","unstructured":"Cho K, S-i Min, Ahn S, Min S-K, Ahn C, Yu K-S, Jang I-J, Cho J-Y, Ha J (2017) Integrative analysis of renal ischemia\/reperfusion injury and remote ischemic preconditioning in mice. J Proteome Res 16(8):2877\u20132886. https:\/\/doi.org\/10.1021\/acs.jproteome.7b00167","journal-title":"J Proteome Res"},{"issue":"1","key":"2984_CR220","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.atherosclerosis.2013.01.041","volume":"228","author":"MJ Dekker","year":"2013","unstructured":"Dekker MJ, Baker C, Naples M, Samsoondar J, Zhang R, Qiu W, Sacco J, Adeli K (2013) Inhibition of sphingolipid synthesis improves dyslipidemia in the diet-induced hamster model of insulin resistance: evidence for the role of\u00a0sphingosine and sphinganine in hepatic VLDL-apoB100 overproduction. Atherosclerosis 228(1):98\u2013109. https:\/\/doi.org\/10.1016\/j.atherosclerosis.2013.01.041","journal-title":"Atherosclerosis"},{"issue":"6","key":"2984_CR221","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1002\/bmc.3194","volume":"28","author":"Y Huang","year":"2014","unstructured":"Huang Y, Liu X, Zhao L, Li F, Xiong Z (2014) Kidney tissue targeted metabolic profiling of glucocorticoid-induced osteoporosis and the proposed therapeutic effects of Rhizoma Drynariae studied using UHPLC\/MS\/MS. Biomed Chromatogr 28(6):878\u2013884. https:\/\/doi.org\/10.1002\/bmc.3194","journal-title":"Biomed Chromatogr"},{"issue":"14","key":"2984_CR222","doi-asserted-by":"publisher","first-page":"10902","DOI":"10.1074\/jbc.M109.077594","volume":"285","author":"Y Pewzner-Jung","year":"2010","unstructured":"Pewzner-Jung Y, Park H, Laviad EL, Silva LC, Lahiri S, Stiban J, Erez-Roman R, Br\u00fcgger B, Sachsenheimer T, Wieland F, Prieto M, Merrill AH, Futerman AH (2010) A critical role for ceramide synthase 2 in liver homeostasis: I. Alterations in lipid metabolic pathways. J Biol Chem 285(14):10902\u201310910. https:\/\/doi.org\/10.1074\/jbc.m109.077594","journal-title":"J Biol Chem"},{"issue":"Suppl 2","key":"2984_CR223","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1289\/ehp.01109s2283","volume":"109","author":"AH Merrill Jr","year":"2001","unstructured":"Merrill AH Jr, Sullards MC, Wang E, Voss KA, Riley RT (2001) Sphingolipid metabolism: roles in signal transduction and disruption by fumonisins. Environ Health Perspect 109(Suppl 2):283\u2013289. https:\/\/doi.org\/10.1289\/ehp.01109s2283","journal-title":"Environ Health Perspect"},{"issue":"9","key":"2984_CR224","doi-asserted-by":"publisher","first-page":"5677","DOI":"10.1074\/jbc.M707386200","volume":"283","author":"EL Laviad","year":"2008","unstructured":"Laviad EL, Albee L, Pankova-Kholmyansky I, Epstein S, Park H, Merrill AH Jr, Futerman AH (2008) Characterization of ceramide synthase 2: tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate. J Biol Chem 283(9):5677\u20135684. https:\/\/doi.org\/10.1074\/jbc.M707386200","journal-title":"J Biol Chem"},{"issue":"1","key":"2984_CR225","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0022-3565(24)37408-7","volume":"285","author":"RR Dugyala","year":"1998","unstructured":"Dugyala RR, Sharma RP, Tsunoda M, Riley RT (1998) Tumor necrosis factor-\u03b1 as a contributor in Fumonisin B1 toxicity. J Pharmacol Exp Ther 285(1):317","journal-title":"J Pharmacol Exp Ther"},{"key":"2984_CR226","doi-asserted-by":"publisher","unstructured":"Bhandari N, He Q, Sharma PR (2001) Gender-related differences in subacute fumonisin B1 hepatotoxicity in BALB\/c mice, vol 165. https:\/\/doi.org\/10.1016\/s0300-483x(01)00449-8","DOI":"10.1016\/s0300-483x(01)00449-8"},{"issue":"1","key":"2984_CR227","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1006\/taap.2001.9189","volume":"174","author":"Q He","year":"2001","unstructured":"He Q, Riley RT, Sharma RP (2001) Fumonisin-induced tumor necrosis factor-alpha expression in a porcine kidney cell line is independent of sphingoid base accumulation induced by ceramide synthase inhibition. Toxicol Appl Pharmacol 174(1):69\u201377. https:\/\/doi.org\/10.1006\/taap.2001.9189","journal-title":"Toxicol Appl Pharmacol"},{"issue":"2","key":"2984_CR228","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/S0300-483X(99)00168-7","volume":"143","author":"RP Sharma","year":"2000","unstructured":"Sharma RP, Bhandari N, Riley RT, Voss KA, Meredith FI (2000) Tolerance to fumonisin toxicity in a mouse strain lacking the P75 tumor necrosis factor receptor. Toxicology 143(2):183\u2013194. https:\/\/doi.org\/10.1016\/S0300-483X(99)00168-7","journal-title":"Toxicology"},{"key":"2984_CR229","doi-asserted-by":"publisher","first-page":"892930","DOI":"10.1155\/2015\/892930","volume":"2015","author":"X Chen","year":"2015","unstructured":"Chen X, Hu C, Dai J, Chen L (2015) Metabolomics analysis of seminal plasma in infertile males with kidney-yang deficiency: a preliminary study. Evid Based Complement Alternat Med 2015:892930. https:\/\/doi.org\/10.1155\/2015\/892930","journal-title":"Evid Based Complement Alternat Med"},{"issue":"1","key":"2984_CR230","doi-asserted-by":"publisher","first-page":"48","DOI":"10.3109\/1354750X.2011.637180","volume":"17","author":"YY Zhao","year":"2012","unstructured":"Zhao YY, Cheng XL, Wei F, Xiao XY, Sun WJ, Zhang Y, Lin RC (2012) Serum metabonomics study of adenine-induced chronic renal failure in rats by ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. Biomarkers 17(1):48\u201355. https:\/\/doi.org\/10.3109\/1354750X.2011.637180","journal-title":"Biomarkers"},{"issue":"1","key":"2984_CR231","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.aca.2009.02.027","volume":"650","author":"J Zhang","year":"2009","unstructured":"Zhang J, Yan L, Chen W, Lin L, Song X, Yan X, Hang W, Huang B (2009) Metabonomics research of diabetic nephropathy and type 2 diabetes mellitus based on UPLC\u2014oaTOF-MS system. Anal Chim Acta 650(1):16\u201322. https:\/\/doi.org\/10.1016\/j.aca.2009.02.027","journal-title":"Anal Chim Acta"},{"issue":"14","key":"2984_CR232","doi-asserted-by":"publisher","first-page":"2238","DOI":"10.1002\/pmic.201200016","volume":"12","author":"L Lin","year":"2012","unstructured":"Lin L, Huang Z, Gao Y, Chen Y, Hang W, Xing J, Yan X (2012) LC-MS-based serum metabolic profiling for genitourinary cancer classification and cancer type-specific biomarker discovery. Proteomics 12(14):2238\u20132246. https:\/\/doi.org\/10.1002\/pmic.201200016","journal-title":"Proteomics"},{"issue":"4","key":"2984_CR233","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1111\/j.1748-1716.2007.01755.x","volume":"192","author":"M Baranowski","year":"2008","unstructured":"Baranowski M, Zabielski P, Blachnio A, Gorski J (2008) Effect of exercise duration on ceramide metabolism in the rat heart. Acta Physiol (Oxf) 192(4):519\u2013529. https:\/\/doi.org\/10.1111\/j.1748-1716.2007.01755.x","journal-title":"Acta Physiol (Oxf)"},{"issue":"3","key":"2984_CR234","first-page":"385","volume":"66","author":"B Wojcik","year":"2015","unstructured":"Wojcik B, Baranowski M, Chabowski A, Gorski J (2015) Effect of atrial pacing on the level of bioactive sphingolipids in the heart ventricles of the rat. J Physiol Pharmacol 66(3):385\u2013389","journal-title":"J Physiol Pharmacol"},{"issue":"10","key":"2984_CR235","doi-asserted-by":"publisher","first-page":"2198","DOI":"10.1002\/jssc.201601013","volume":"40","author":"L Sun","year":"2017","unstructured":"Sun L, Liu J, Sun M, Lin L, Miao L, Ge Z, Yang B (2017) Comprehensive metabonomic analysis of heart tissue from isoproterenol-induced myocardial infarction rat based on reversed-phase and hydrophilic interaction chromatography coupled to mass spectrometry. J Sep Sci 40(10):2198\u20132206. https:\/\/doi.org\/10.1002\/jssc.201601013","journal-title":"J Sep Sci"},{"key":"2984_CR236","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1155\/2013\/438680","volume":"2013","author":"Y Qi","year":"2013","unstructured":"Qi Y, Gu H, Song Y, Dong X, Liu A, Lou Z, Fan G, Chai Y (2013) Metabolomics study of resina draconis on myocardial ischemia rats using ultraperformance liquid chromatography\/quadrupole time-of-flight mass spectrometry combined with pattern recognition methods and metabolic pathway analysis. Evidence Based Complement Altern Med 2013:10. https:\/\/doi.org\/10.1155\/2013\/438680","journal-title":"Evidence Based Complement Altern Med"},{"key":"2984_CR237","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.jpba.2013.11.008","volume":"90","author":"Liu Y-t","year":"2014","unstructured":"Y-t Liu, H-m Jia, Chang X, W-h Cheng, Zhao X, Ding G, H-w Zhang, D-y Cai, Zou Z-M (2014) Metabolic pathways involved in Xin-Ke-Shu protecting against myocardial infarction in rats using ultra high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. J Pharm Biomed Anal 90:35\u201344. https:\/\/doi.org\/10.1016\/j.jpba.2013.11.008","journal-title":"J Pharm Biomed Anal"},{"issue":"2","key":"2984_CR238","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1159\/000369735","volume":"35","author":"A Miklosz","year":"2015","unstructured":"Miklosz A, Lukaszuk B, Chabowski A, Rogowski F, Kurek K, Zendzian-Piotrowska M (2015) Hyperthyroidism evokes myocardial ceramide accumulation. Cell Physiol Biochem 35(2):755\u2013766. https:\/\/doi.org\/10.1159\/000369735","journal-title":"Cell Physiol Biochem"},{"issue":"2","key":"2984_CR239","first-page":"878","volume":"9","author":"MT Park","year":"2003","unstructured":"Park MT, Kang JA, Choi JA, Kang CM, Kim TH, Bae S, Kang S, Kim S, Choi WI, Cho CK, Chung HY, Lee YS, Lee SJ (2003) Phytosphingosine induces apoptotic cell death via caspase 8 activation and Bax translocation in human cancer cells. Clin Cancer Res 9(2):878\u2013885","journal-title":"Clin Cancer Res"},{"key":"2984_CR240","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.jchromb.2018.01.038","volume":"1079","author":"Y Yang","year":"2018","unstructured":"Yang Y, Jia H, Yu M, Zhou C, Sun L, Zhao Y, Zhang H, Zou Z (2018) Chinese patent medicine Xin-Ke-Shu inhibits Ca2+ overload and dysfunction of fatty acid \u03b2-oxidation in rats with myocardial infarction induced by LAD ligation. J Chromatogr B 1079:85\u201394. https:\/\/doi.org\/10.1016\/j.jchromb.2018.01.038","journal-title":"J Chromatogr B"},{"issue":"1","key":"2984_CR241","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.advms.2015.09.006","volume":"61","author":"A B\u0142achnio-Zabielska","year":"2016","unstructured":"B\u0142achnio-Zabielska A, Baranowski M, W\u00f3jcik B, G\u00f3rski J (2016) Reduction of ceramide de novo synthesis in solid tissues changes sphingolipid levels in rat plasma, erythrocytes and platelets. Adv Med Sci 61(1):72\u201377. https:\/\/doi.org\/10.1016\/j.advms.2015.09.006","journal-title":"Adv Med Sci"},{"issue":"9","key":"2984_CR242","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.4103\/0366-6999.180527","volume":"129","author":"L Huang","year":"2016","unstructured":"Huang L, Li T, Liu YW, Zhang L, Dong ZH, Liu SY, Gao YT (2016) Plasma metabolic profile determination in young ST-segment elevation myocardial infarction patients with ischemia and reperfusion: ultra-performance liquid chromatography and mass spectrometry for pathway analysis. Chin Med J (Engl) 129(9):1078\u20131086. https:\/\/doi.org\/10.4103\/0366-6999.180527","journal-title":"Chin Med J (Engl)"},{"issue":"1","key":"2984_CR243","doi-asserted-by":"publisher","first-page":"100","DOI":"10.2478\/v10039-011-0057-4","volume":"57","author":"M Knapp","year":"2012","unstructured":"Knapp M, Baranowski M, Lisowska A, Musia\u0142 W (2012) Decreased free sphingoid base concentration in the plasma of patients with chronic systolic heart failure. Adv Med Sci 57(1):100\u2013105. https:\/\/doi.org\/10.2478\/v10039-011-0057-4","journal-title":"Adv Med Sci"},{"issue":"3","key":"2984_CR244","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1007\/s10337-013-2585-5","volume":"77","author":"M Sun","year":"2014","unstructured":"Sun M, Miao Y, Wang P, Miao L, Liu L, Liu J (2014) Urinary metabonomics study of heart failure patients with HILIC and RPLC separation coupled to TOF\u2013MS. Chromatographia 77(3):249\u2013255. https:\/\/doi.org\/10.1007\/s10337-013-2585-5","journal-title":"Chromatographia"},{"key":"2984_CR245","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.atherosclerosis.2017.05.010","volume":"262","author":"Y Chen","year":"2017","unstructured":"Chen Y, Wen S, Jiang M, Zhu Y, Ding L, Shi H, Dong P, Yang J, Yang Y (2017) Atherosclerotic dyslipidemia revealed by plasma lipidomics on ApoE(\u2212\/\u2212) mice fed a high-fat diet. Atherosclerosis 262:78\u201386. https:\/\/doi.org\/10.1016\/j.atherosclerosis.2017.05.010","journal-title":"Atherosclerosis"},{"key":"2984_CR246","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.jchromb.2015.08.010","volume":"1002","author":"H Jiang","year":"2015","unstructured":"Jiang H, Shen Z, Chu Y, Li Y, Li J, Wang X, Yang W, Zhang X, Ju J, Xu J, Yang C (2015) Serum metabolomics research of the anti-hypertensive effects of Tengfu Jiangya tablet on spontaneously hypertensive rats. J Chromatogr B Analyt Technol Biomed Life Sci 1002:210\u2013217. https:\/\/doi.org\/10.1016\/j.jchromb.2015.08.010","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"issue":"11","key":"2984_CR247","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1016\/j.phymed.2014.05.009","volume":"21","author":"Y-T Liu","year":"2014","unstructured":"Liu Y-T, Peng J-B, Jia H-M, Cai D-Y, Zhang H-W, Yu C-Y, Zou Z-M (2014) UPLC-Q\/TOF MS standardized Chinese formula Xin-Ke-Shu for the treatment of atherosclerosis in a rabbit model. Phytomedicine 21(11):1364\u20131372. https:\/\/doi.org\/10.1016\/j.phymed.2014.05.009","journal-title":"Phytomedicine"},{"key":"2984_CR248","doi-asserted-by":"publisher","first-page":"130","DOI":"10.3389\/fphys.2013.00130","volume":"4","author":"EE Egom","year":"2013","unstructured":"Egom EE, Mamas MA, Chacko S, Stringer SE, Charlton-Menys V, El-Omar M, Chirico D, Clarke B, Neyses L, Cruickshank JK, Lei M, Fath-Ordoubadi F (2013) Serum sphingolipids level as a novel potential marker for early detection of human myocardial ischaemic injury. Front Physiol 4:130. https:\/\/doi.org\/10.3389\/fphys.2013.00130","journal-title":"Front Physiol"},{"issue":"1","key":"2984_CR249","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.phrs.2008.06.005","volume":"58","author":"TS Park","year":"2008","unstructured":"Park TS, Rosebury W, Kindt EK, Kowala MC, Panek RL (2008) Serine palmitoyltransferase inhibitor myriocin induces the regression of atherosclerotic plaques in hyperlipidemic ApoE-deficient mice. Pharmacol Res 58(1):45\u201351. https:\/\/doi.org\/10.1016\/j.phrs.2008.06.005","journal-title":"Pharmacol Res"},{"issue":"2","key":"2984_CR250","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/S0014-4827(03)00235-0","volume":"288","author":"V Dolgachev","year":"2003","unstructured":"Dolgachev V, Nagy B, Taffe B, Hanada K, Separovic D (2003) Reactive oxygen species generation is independent of de novo sphingolipids in apoptotic photosensitized cells. Exp Cell Res 288(2):425\u2013436. https:\/\/doi.org\/10.1016\/S0014-4827(03)00235-0","journal-title":"Exp Cell Res"},{"issue":"4","key":"2984_CR251","doi-asserted-by":"publisher","first-page":"1373.e1374","DOI":"10.1016\/j.jaci.2016.08.053","volume":"139","author":"M Miller","year":"2017","unstructured":"Miller M, Rosenthal P, Beppu A, Gordillo R, Broide DH (2017) Oroscomucoid like protein 3 (ORMDL3) transgenic mice have reduced levels of sphingolipids including sphingosine-1-phosphate and ceramide. J Allergy Clin Immunol 139(4):1373.e1374\u20131376.e1374. https:\/\/doi.org\/10.1016\/j.jaci.2016.08.053","journal-title":"J Allergy Clin Immunol"},{"issue":"7284","key":"2984_CR252","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1038\/nature08787","volume":"463","author":"DK Breslow","year":"2010","unstructured":"Breslow DK, Collins SR, Bodenmiller B, Aebersold R, Simons K, Shevchenko A, Ejsing CS, Weissman JS (2010) Orm family proteins mediate sphingolipid homeostasis. Nature 463(7284):1048\u20131053. https:\/\/doi.org\/10.1038\/nature08787","journal-title":"Nature"},{"issue":"3","key":"2984_CR253","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.jdermsci.2013.08.003","volume":"72","author":"N Loiseau","year":"2013","unstructured":"Loiseau N, Obata Y, Moradian S, Sano H, Yoshino S, Aburai K, Takayama K, Sakamoto K, Holleran WM, Elias PM, Uchida Y (2013) Altered sphingoid base profiles predict compromised membrane structure and permeability in atopic dermatitis. J Dermatol Sci 72(3):296\u2013303. https:\/\/doi.org\/10.1016\/j.jdermsci.2013.08.003","journal-title":"J Dermatol Sci"},{"issue":"2","key":"2984_CR254","doi-asserted-by":"publisher","first-page":"e43","DOI":"10.1016\/j.jdermsci.2017.02.128","volume":"86","author":"Y Obata","year":"2017","unstructured":"Obata Y, Sano H, Ohta N, Moriwaki T, Ishida K, Uchida Y, Takayama K (2017) Characterization of simple intercellular lipid model of atopic dermatitis stratum corneum containing sphingosine and sphinganine. J Dermatol Sci 86(2):e43\u2013e44. https:\/\/doi.org\/10.1016\/j.jdermsci.2017.02.128","journal-title":"J Dermatol Sci"},{"key":"2984_CR255","doi-asserted-by":"publisher","first-page":"154762","DOI":"10.1155\/2015\/154762","volume":"2015","author":"K Kurek","year":"2015","unstructured":"Kurek K, Miklosz A, Lukaszuk B, Chabowski A, Gorski J, Zendzian-Piotrowska M (2015) Inhibition of ceramide de novo synthesis ameliorates diet induced skeletal muscles insulin resistance. J Diabetes Res 2015:154762. https:\/\/doi.org\/10.1155\/2015\/154762","journal-title":"J Diabetes Res"},{"issue":"5","key":"2984_CR256","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1002\/ptr.5587","volume":"30","author":"Y Dong","year":"2016","unstructured":"Dong Y, Chen YT, Yang YX, Zhou XJ, Dai SJ, Tong JF, Shou D, Li C (2016) Metabolomics study of type 2 diabetes mellitus and the antidiabetic effect of berberine in Zucker diabetic fatty rats using Uplc-ESI-Hdms. Phytother Res 30(5):823\u2013828. https:\/\/doi.org\/10.1002\/ptr.5587","journal-title":"Phytother Res"},{"key":"2984_CR257","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.jchromb.2016.12.039","volume":"1044\u20131045","author":"W Jiang","year":"2017","unstructured":"Jiang W, Gao L, Li P, Kan H, Qu J, Men L, Liu Z, Liu Z (2017) Metabonomics study of the therapeutic mechanism of fenugreek galactomannan on diabetic hyperglycemia in rats, by ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. J Chromatogr B 1044\u20131045:8\u201316. https:\/\/doi.org\/10.1016\/j.jchromb.2016.12.039","journal-title":"J Chromatogr B"},{"issue":"1","key":"2984_CR258","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1007\/s11306-014-0669-3","volume":"11","author":"S Jung","year":"2015","unstructured":"Jung S, Kim M, Ryu HJ, Chae JS, Lee S-H, Lee JH (2015) Age-related increase in LDL-cholesterol is associated with enhanced oxidative stress and disturbed sphingolipid metabolism. Metabolomics 11(1):40\u201349. https:\/\/doi.org\/10.1007\/s11306-014-0669-3","journal-title":"Metabolomics"},{"issue":"16","key":"2984_CR259","doi-asserted-by":"publisher","first-page":"3039","DOI":"10.1007\/s00018-017-2518-9","volume":"74","author":"S Oertel","year":"2017","unstructured":"Oertel S, Scholich K, Weigert A, Thomas D, Schmetzer J, Trautmann S, Wegner M-S, Radeke HH, Filmann N, Br\u00fcne B, Geisslinger G, Tegeder I, Gr\u00f6sch S (2017) Ceramide synthase 2 deficiency aggravates AOM-DSS-induced colitis in mice: role of colon barrier integrity. Cell Mol Life Sci 74(16):3039\u20133055. https:\/\/doi.org\/10.1007\/s00018-017-2518-9","journal-title":"Cell Mol Life Sci"},{"issue":"6","key":"2984_CR260","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1111\/acel.12388","volume":"14","author":"S Choi","year":"2015","unstructured":"Choi S, Kim JA, Kim TH, Li HY, Shin KO, Lee YM, Oh S, Pewzner-Jung Y, Futerman AH, Suh SH (2015) Altering sphingolipid composition with aging induces contractile dysfunction of gastric smooth muscle via K(Ca) 1.1 upregulation. Aging Cell 14(6):982\u2013994. https:\/\/doi.org\/10.1111\/acel.12388","journal-title":"Aging Cell"},{"issue":"6","key":"2984_CR261","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1002\/jcla.21969","volume":"30","author":"H Xu","year":"2016","unstructured":"Xu H, Zhang L, Kang H, Zhang J, Liu J, Liu S (2016) Serum metabonomics of mild acute pancreatitis. J Clin Lab Anal 30(6):990\u2013998. https:\/\/doi.org\/10.1002\/jcla.21969","journal-title":"J Clin Lab Anal"},{"key":"2984_CR262","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.jpba.2016.03.032","volume":"127","author":"C Barbas-Bernardos","year":"2016","unstructured":"Barbas-Bernardos C, Armitage EG, Garc\u00eda A, M\u00e9rida S, Navea A, Bosch-Morell F, Barbas C (2016) Looking into aqueous humor through metabolomics spectacles\u2014exploring its metabolic characteristics in relation to myopia. J Pharm Biomed Anal 127:18\u201325. https:\/\/doi.org\/10.1016\/j.jpba.2016.03.032","journal-title":"J Pharm Biomed Anal"},{"key":"2984_CR263","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.jpba.2017.06.049","volume":"145","author":"Z Sui","year":"2017","unstructured":"Sui Z, Li Q, Zhu L, Wang Z, Lv C, Liu R, Xu H, He B, Li Z, Bi K (2017) An integrative investigation of the toxicity of Aconiti kusnezoffii radix and the attenuation effect of its processed drug using a UHPLC-Q-TOF based rat serum and urine metabolomics strategy. J Pharm Biomed Anal 145:240\u2013247. https:\/\/doi.org\/10.1016\/j.jpba.2017.06.049","journal-title":"J Pharm Biomed Anal"},{"issue":"5","key":"2984_CR264","doi-asserted-by":"publisher","first-page":"e0177601","DOI":"10.1371\/journal.pone.0177601","volume":"12","author":"K Charkiewicz","year":"2017","unstructured":"Charkiewicz K, Goscik J, Blachnio-Zabielska A, Raba G, Sakowicz A, Kalinka J, Chabowski A, Laudanski P (2017) Sphingolipids as a new factor in the pathomechanism of preeclampsia\u2014mass spectrometry analysis. PLoS One 12(5):e0177601. https:\/\/doi.org\/10.1371\/journal.pone.0177601","journal-title":"PLoS One"},{"issue":"11","key":"2984_CR265","doi-asserted-by":"publisher","first-page":"4000","DOI":"10.1021\/acs.jproteome.7b00401","volume":"16","author":"A Zmyslowska","year":"2017","unstructured":"Zmyslowska A, Ciborowski M, Borowiec M, Fendler W, Pietrowska K, Parfieniuk E, Antosik K, Pyziak A, Waszczykowska A, Kretowski A, Mlynarski W (2017) Serum metabolic fingerprinting identified putatively annotated sphinganine isomer as a biomarker of Wolfram syndrome. J Proteome Res 16(11):4000\u20134008. https:\/\/doi.org\/10.1021\/acs.jproteome.7b00401","journal-title":"J Proteome Res"},{"issue":"5","key":"2984_CR266","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.ejmg.2013.02.002","volume":"56","author":"M Auer-Grumbach","year":"2013","unstructured":"Auer-Grumbach M, Bode H, Pieber TR, Schabh\u00fcttl M, Fischer D, Seidl R, Graf E, Wieland T, Schuh R, Vacariu G, Grill F, Timmerman V, Strom TM, Hornemann T (2013) Mutations at Ser331 in the HSN type I gene SPTLC1 are associated with a distinct syndromic phenotype. Eur J Med Genet 56(5):266\u2013269. https:\/\/doi.org\/10.1016\/j.ejmg.2013.02.002","journal-title":"Eur J Med Genet"},{"key":"2984_CR267","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.jns.2017.08.3516","volume":"381","author":"CT Hsiao","year":"2017","unstructured":"Hsiao CT, Chao HC, Liao YC, Lin KP, Soong BW, Lee YC (2017) Investigation for SPTLC1 mutations in a Taiwanese cohort with hereditary neuropathies. J Neurol Sci 381:463\u2013464. https:\/\/doi.org\/10.1016\/j.jns.2017.08.3516","journal-title":"J Neurol Sci"},{"issue":"23","key":"2984_CR268","doi-asserted-by":"publisher","first-page":"2106","DOI":"10.1212\/WNL.0b013e318295d789","volume":"80","author":"SM Murphy","year":"2013","unstructured":"Murphy SM, Ernst D, Wei Y, Laura M, Liu YT, Polke J, Blake J, Winer J, Houlden H, Hornemann T, Reilly MM (2013) Hereditary sensory and autonomic neuropathy type 1 (HSANI) caused by a novel mutation in SPTLC2. Neurology 80(23):2106\u20132111. https:\/\/doi.org\/10.1212\/WNL.0b013e318295d789","journal-title":"Neurology"},{"issue":"9","key":"2984_CR269","doi-asserted-by":"publisher","first-page":"2452","DOI":"10.1016\/j.bmc.2018.04.008","volume":"26","author":"T Kojima","year":"2018","unstructured":"Kojima T, Asano Y, Kurasawa O, Hirata Y, Iwamura N, Wong T-T, Saito B, Tanaka Y, Arai R, Yonemori K, Miyamoto Y, Sagiya Y, Yaguchi M, Shibata S, Mizutani A, Sano O, Adachi R, Satomi Y, Hirayama M, Aoyama K, Hiura Y, Kiba A, Kitamura S, Imamura S (2018) Discovery of novel serine palmitoyltransferase inhibitors as cancer therapeutic agents. Bioorg Med Chem 26(9):2452\u20132465. https:\/\/doi.org\/10.1016\/j.bmc.2018.04.008","journal-title":"Bioorg Med Chem"},{"issue":"6","key":"2984_CR270","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1016\/j.ajhg.2017.05.003","volume":"100","author":"LM Boyden","year":"2017","unstructured":"Boyden LM, Vincent NG, Zhou J, Hu R, Craiglow BG, Bayliss SJ, Rosman IS, Lucky AW, Diaz LA, Goldsmith LA, Paller AS, Lifton RP, Baserga SJ, Choate KA (2017) Mutations in KDSR cause recessive progressive symmetric erythrokeratoderma. Am J Hum Genet 100(6):978\u2013984. https:\/\/doi.org\/10.1016\/j.ajhg.2017.05.003","journal-title":"Am J Hum Genet"},{"issue":"11","key":"2984_CR271","doi-asserted-by":"publisher","first-page":"2344","DOI":"10.1016\/j.jid.2017.06.028","volume":"137","author":"T Takeichi","year":"2017","unstructured":"Takeichi T, Torrelo A, Lee JYW, Ohno Y, Lozano ML, Kihara A, Liu L, Yasuda Y, Ishikawa J, Murase T, Rodrigo AB, Fern\u00e1ndez-Crehuet P, Toi Y, Mellerio J, Rivera J, Vicente V, Kelsell DP, Nishimura Y, Okuno Y, Kojima D, Ogawa Y, Sugiura K, Simpson MA, McLean WHI, Akiyama M, McGrath JA (2017) Biallelic mutations in KDSR disrupt ceramide synthesis and result in a\u00a0spectrum of keratinization disorders associated with thrombocytopenia. J Invest Dermatol 137(11):2344\u20132353. https:\/\/doi.org\/10.1016\/j.jid.2017.06.028","journal-title":"J Invest Dermatol"},{"issue":"16","key":"2984_CR272","doi-asserted-by":"publisher","first-page":"6746","DOI":"10.1073\/pnas.0607721104","volume":"104","author":"S Krebs","year":"2007","unstructured":"Krebs S, Medugorac I, R\u00f6ther S, Str\u00e4sser K, F\u00f6rster M (2007) A missense mutation in the 3-ketodihydrosphingosine reductase FVT1 as candidate causal mutation for bovine spinal muscular atrophy. Proc Natl Acad Sci USA 104(16):6746\u20136751. https:\/\/doi.org\/10.1073\/pnas.0607721104","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"2984_CR273","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1039\/C5MB00852B","volume":"12","author":"YF Ordonez","year":"2016","unstructured":"Ordonez YF, Gonzalez J, Bedia C, Casas J, Abad JL, Delgado A, Fabrias G (2016) 3-Ketosphinganine provokes the accumulation of dihydroshingolipids and induces autophagy in cancer cells. Mol BioSyst 12(4):1166\u20131173. https:\/\/doi.org\/10.1039\/C5MB00852B","journal-title":"Mol BioSyst"}],"container-title":["Cellular and Molecular Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-018-2984-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00018-018-2984-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-018-2984-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T09:45:31Z","timestamp":1775295931000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00018-018-2984-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,6]]},"references-count":273,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["2984"],"URL":"https:\/\/doi.org\/10.1007\/s00018-018-2984-8","relation":{},"ISSN":["1420-682X","1420-9071"],"issn-type":[{"value":"1420-682X","type":"print"},{"value":"1420-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,6]]},"assertion":[{"value":"19 July 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 November 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 November 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 December 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that there is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}