{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:47:50Z","timestamp":1790682470681,"version":"4.1.0"},"reference-count":120,"publisher":"Springer Science and Business Media LLC","issue":"17","license":[{"start":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T00:00:00Z","timestamp":1554249600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T00:00:00Z","timestamp":1554249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM083165"],"award-info":[{"award-number":["GM083165"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM083165-03S1"],"award-info":[{"award-number":["GM083165-03S1"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["EY019492"],"award-info":[{"award-number":["EY019492"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["P30 EY025585"],"award-info":[{"award-number":["P30 EY025585"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell. Mol. Life Sci."],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1007\/s00018-019-03078-5","type":"journal-article","created":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T02:50:49Z","timestamp":1554346249000},"page":"3407-3432","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Microglial activation in an amyotrophic lateral sclerosis-like model caused by Ranbp2 loss and nucleocytoplasmic transport impairment in retinal ganglion neurons"],"prefix":"10.1007","volume":"76","author":[{"given":"Kyoung-in","family":"Cho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dosuk","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minzhong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal S.","family":"Peachey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4585-1717","authenticated-orcid":false,"given":"Paulo A.","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,4,3]]},"reference":[{"issue":"6","key":"3078_CR1","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1007\/s00401-006-0130-4","volume":"112","author":"J Zhang","year":"2006","unstructured":"Zhang J, Ito H, Wate R, Ohnishi S, Nakano S, Kusaka H (2006) Altered distributions of nucleocytoplasmic transport-related proteins in the spinal cord of a mouse model of amyotrophic lateral sclerosis. Acta Neuropathol 112(6):673\u2013680. https:\/\/doi.org\/10.1007\/s00401-006-0130-4","journal-title":"Acta Neuropathol"},{"issue":"11","key":"3078_CR2","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.1097\/NEN.0b013e3181bc3bec","volume":"68","author":"Y Kinoshita","year":"2009","unstructured":"Kinoshita Y, Ito H, Hirano A, Fujita K, Wate R, Nakamura M, Kaneko S, Nakano S, Kusaka H (2009) Nuclear contour irregularity and abnormal transporter protein distribution in anterior horn cells in amyotrophic lateral sclerosis. J Neuropathol Exp Neurol 68(11):1184\u20131192. https:\/\/doi.org\/10.1097\/NEN.0b013e3181bc3bec","journal-title":"J Neuropathol Exp Neurol"},{"issue":"16","key":"3078_CR3","doi-asserted-by":"publisher","first-page":"2841","DOI":"10.1038\/emboj.2010.143","volume":"29","author":"D Dormann","year":"2010","unstructured":"Dormann D, Rodde R, Edbauer D, Bentmann E, Fischer I, Hruscha A, Than ME, Mackenzie IR, Capell A, Schmid B, Neumann M, Haass C (2010) ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import. EMBO J 29(16):2841\u20132857. https:\/\/doi.org\/10.1038\/emboj.2010.143","journal-title":"EMBO J"},{"issue":"4","key":"3078_CR4","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1002\/ana.24469","volume":"78","author":"S Xiao","year":"2015","unstructured":"Xiao S, MacNair L, McGoldrick P, McKeever PM, McLean JR, Zhang M, Keith J, Zinman L, Rogaeva E, Robertson J (2015) Isoform-specific antibodies reveal distinct subcellular localizations of C9orf72 in amyotrophic lateral sclerosis. Ann Neurol 78(4):568\u2013583. https:\/\/doi.org\/10.1002\/ana.24469","journal-title":"Ann Neurol"},{"issue":"5","key":"3078_CR5","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1111\/bpa.12040","volume":"23","author":"Y Nagara","year":"2013","unstructured":"Nagara Y, Tateishi T, Yamasaki R, Hayashi S, Kawamura M, Kikuchi H, Iinuma KM, Tanaka M, Iwaki T, Matsushita T, Ohyagi Y, Kira J (2013) Impaired cytoplasmic-nuclear transport of hypoxia-inducible factor-1alpha in amyotrophic lateral sclerosis. Brain Pathol 23(5):534\u2013546. https:\/\/doi.org\/10.1111\/bpa.12040","journal-title":"Brain Pathol"},{"issue":"10","key":"3078_CR6","doi-asserted-by":"publisher","first-page":"1937","DOI":"10.1084\/jem.20140214","volume":"211","author":"ME Ward","year":"2014","unstructured":"Ward ME, Taubes A, Chen R, Miller BL, Sephton CF, Gelfand JM, Minami S, Boscardin J, Martens LH, Seeley WW, Yu G, Herz J, Filiano AJ, Arrant AE, Roberson ED, Kraft TW, Farese RV Jr, Green A, Gan L (2014) Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD. J Exp Med 211(10):1937\u20131945. https:\/\/doi.org\/10.1084\/jem.20140214","journal-title":"J Exp Med"},{"issue":"7567","key":"3078_CR7","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1038\/nature14974","volume":"525","author":"BD Freibaum","year":"2015","unstructured":"Freibaum BD, Lu Y, Lopez-Gonzalez R, Kim NC, Almeida S, Lee KH, Badders N, Valentine M, Miller BL, Wong PC, Petrucelli L, Kim HJ, Gao FB, Taylor JP (2015) GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport. Nature 525(7567):129\u2013133. https:\/\/doi.org\/10.1038\/nature14974","journal-title":"Nature"},{"issue":"7567","key":"3078_CR8","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/nature14973","volume":"525","author":"K Zhang","year":"2015","unstructured":"Zhang K, Donnelly CJ, Haeusler AR, Grima JC, Machamer JB, Steinwald P, Daley EL, Miller SJ, Cunningham KM, Vidensky S, Gupta S, Thomas MA, Hong I, Chiu SL, Huganir RL, Ostrow LW, Matunis MJ, Wang J, Sattler R, Lloyd TE, Rothstein JD (2015) The C9orf72 repeat expansion disrupts nucleocytoplasmic transport. Nature 525(7567):56\u201361. https:\/\/doi.org\/10.1038\/nature14973","journal-title":"Nature"},{"key":"3078_CR9","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.neuroscience.2017.03.024","volume":"350","author":"J Shang","year":"2017","unstructured":"Shang J, Yamashita T, Nakano Y, Morihara R, Li X, Feng T, Liu X, Huang Y, Fukui Y, Hishikawa N, Ohta Y, Abe K (2017) Aberrant distributions of nuclear pore complex proteins in ALS mice and ALS patients. Neuroscience 350:158\u2013168. https:\/\/doi.org\/10.1016\/j.neuroscience.2017.03.024","journal-title":"Neuroscience"},{"key":"3078_CR10","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-019-03029-0","author":"PA Ferreira","year":"2019","unstructured":"Ferreira PA (2019) The coming-of-age of nucleocytoplasmic transport in motor neuron disease and neurodegeneration. Cell Mol Life Sci. https:\/\/doi.org\/10.1007\/s00018-019-03029-0 (in press)","journal-title":"Cell Mol Life Sci"},{"issue":"6269","key":"3078_CR11","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1126\/science.aad2033","volume":"351","author":"AC Woerner","year":"2016","unstructured":"Woerner AC, Frottin F, Hornburg D, Feng LR, Meissner F, Patra M, Tatzelt J, Mann M, Winklhofer KF, Hartl FU, Hipp MS (2016) Cytoplasmic protein aggregates interfere with nucleocytoplasmic transport of protein and RNA. Science 351(6269):173\u2013176. https:\/\/doi.org\/10.1126\/science.aad2033","journal-title":"Science"},{"issue":"1","key":"3078_CR12","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.neuron.2017.03.023","volume":"94","author":"JC Grima","year":"2017","unstructured":"Grima JC, Daigle JG, Arbez N, Cunningham KC, Zhang K, Ochaba J, Geater C, Morozko E, Stocksdale J, Glatzer JC, Pham JT, Ahmed I, Peng Q, Wadhwa H, Pletnikova O, Troncoso JC, Duan W, Snyder SH, Ranum LPW, Thompson LM, Lloyd TE, Ross CA, Rothstein JD (2017) Mutant huntingtin disrupts the nuclear pore complex. Neuron 94(1):93\u2013107 e106. https:\/\/doi.org\/10.1016\/j.neuron.2017.03.023","journal-title":"Neuron"},{"issue":"1","key":"3078_CR13","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.neuron.2017.03.027","volume":"94","author":"F Gasset-Rosa","year":"2017","unstructured":"Gasset-Rosa F, Chillon-Marinas C, Goginashvili A, Atwal RS, Artates JW, Tabet R, Wheeler VC, Bang AG, Cleveland DW, Lagier-Tourenne C (2017) Polyglutamine-expanded huntingtin exacerbates age-related disruption of nuclear integrity and nucleocytoplasmic transport. Neuron 94(1):48\u201357 e44. https:\/\/doi.org\/10.1016\/j.neuron.2017.03.027","journal-title":"Neuron"},{"issue":"5","key":"3078_CR14","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1016\/j.neuron.2018.07.039","volume":"99","author":"B Eftekharzadeh","year":"2018","unstructured":"Eftekharzadeh B, Daigle JG, Kapinos LE, Coyne A, Schiantarelli J, Carlomagno Y, Cook C, Miller SJ, Dujardin S, Amaral AS, Grima JC, Bennett RE, Tepper K, DeTure M, Vanderburgh CR, Corjuc BT, DeVos SL, Gonzalez JA, Chew J, Vidensky S, Gage FH, Mertens J, Troncoso J, Mandelkow E, Salvatella X, Lim RYH, Petrucelli L, Wegmann S, Rothstein JD, Hyman BT (2018) Tau protein disrupts nucleocytoplasmic transport in Alzheimer\u2019s disease. Neuron 99(5):925\u2013940 e927. https:\/\/doi.org\/10.1016\/j.neuron.2018.07.039","journal-title":"Neuron"},{"issue":"8","key":"3078_CR15","doi-asserted-by":"publisher","first-page":"1476","DOI":"10.1021\/acschemneuro.5b00134","volume":"6","author":"KI Cho","year":"2015","unstructured":"Cho KI, Orry A, Park SE, Ferreira PA (2015) Targeting the cyclophilin domain of Ran-binding protein 2 (Ranbp2) with novel small molecules to control the proteostasis of STAT3, hnRNPA2B1 and M-Opsin. ACS Chem Neurosci 6(8):1476\u20131485. https:\/\/doi.org\/10.1021\/acschemneuro.5b00134","journal-title":"ACS Chem Neurosci"},{"issue":"9","key":"3078_CR16","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1038\/nn.4085","volume":"18","author":"A Jovicic","year":"2015","unstructured":"Jovicic A, Mertens J, Boeynaems S, Bogaert E, Chai N, Yamada SB, Paul JW 3rd, Sun S, Herdy JR, Bieri G, Kramer NJ, Gage FH, Van Den Bosch L, Robberecht W, Gitler AD (2015) Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD\/ALS. Nat Neurosci 18(9):1226\u20131229. https:\/\/doi.org\/10.1038\/nn.4085","journal-title":"Nat Neurosci"},{"key":"3078_CR17","doi-asserted-by":"publisher","first-page":"20877","DOI":"10.1038\/srep20877","volume":"6","author":"S Boeynaems","year":"2016","unstructured":"Boeynaems S, Bogaert E, Michiels E, Gijselinck I, Sieben A, Jovicic A, De Baets G, Scheveneels W, Steyaert J, Cuijt I, Verstrepen KJ, Callaerts P, Rousseau F, Schymkowitz J, Cruts M, Van Broeckhoven C, Van Damme P, Gitler AD, Robberecht W, Van Den Bosch L (2016) Drosophila screen connects nuclear transport genes to DPR pathology in c9ALS\/FTD. Sci Rep 6:20877. https:\/\/doi.org\/10.1038\/srep20877","journal-title":"Sci Rep"},{"issue":"12","key":"3078_CR18","doi-asserted-by":"publisher","first-page":"2379","DOI":"10.1091\/mbc.8.12.2379","volume":"8","author":"C Delphin","year":"1997","unstructured":"Delphin C, Guan T, Melchior F, Gerace L (1997) RanGTP targets p97 to RanBP2, a filamentous protein localized at the cytoplasmic periphery of the nuclear pore complex. Mol Biol Cell 8(12):2379\u20132390","journal-title":"Mol Biol Cell"},{"issue":"23","key":"3078_CR19","doi-asserted-by":"publisher","first-page":"14209","DOI":"10.1074\/jbc.270.23.14209","volume":"270","author":"J Wu","year":"1995","unstructured":"Wu J, Matunis MJ, Kraemer D, Blobel G, Coutavas E (1995) Nup358, a cytoplasmically exposed nucleoporin with peptide repeats, Ran-GTP binding sites, zinc fingers, a cyclophilin A homologous domain, and a leucine-rich region. J Biol Chem 270(23):14209\u201314213","journal-title":"J Biol Chem"},{"issue":"52","key":"3078_CR20","doi-asserted-by":"publisher","first-page":"37370","DOI":"10.1074\/jbc.274.52.37370","volume":"274","author":"BB Singh","year":"1999","unstructured":"Singh BB, Patel HH, Roepman R, Schick D, Ferreira PA (1999) The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1. J Biol Chem 274(52):37370\u201337378","journal-title":"J Biol Chem"},{"issue":"2","key":"3078_CR21","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.celrep.2012.07.007","volume":"2","author":"B Culjkovic-Kraljacic","year":"2012","unstructured":"Culjkovic-Kraljacic B, Baguet A, Volpon L, Amri A, Borden KL (2012) The oncogene eIF4E reprograms the nuclear pore complex to promote mRNA export and oncogenic transformation. Cell Rep 2(2):207\u2013215. https:\/\/doi.org\/10.1016\/j.celrep.2012.07.007","journal-title":"Cell Rep"},{"issue":"4","key":"3078_CR22","doi-asserted-by":"publisher","first-page":"e1001545","DOI":"10.1371\/journal.pbio.1001545","volume":"11","author":"K Mahadevan","year":"2013","unstructured":"Mahadevan K, Zhang H, Akef A, Cui XA, Gueroussov S, Cenik C, Roth FP, Palazzo AF (2013) RanBP2\/Nup358 potentiates the translation of a subset of mRNAs encoding secretory proteins. PLoS Biol 11(4):e1001545. https:\/\/doi.org\/10.1371\/journal.pbio.1001545","journal-title":"PLoS Biol"},{"issue":"6722","key":"3078_CR23","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/17969","volume":"398","author":"IR Vetter","year":"1999","unstructured":"Vetter IR, Nowak C, Nishimoto T, Kuhlmann J, Wittinghofer A (1999) Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport. Nature 398(6722):39\u201346","journal-title":"Nature"},{"issue":"38","key":"3078_CR24","doi-asserted-by":"publisher","first-page":"11629","DOI":"10.1021\/bi001010f","volume":"39","author":"CI Villa Braslavsky","year":"2000","unstructured":"Villa Braslavsky CI, Nowak C, Gorlich D, Wittinghofer A, Kuhlmann J (2000) Different structural and kinetic requirements for the interaction of Ran with the Ran-binding domains from RanBP2 and importin-beta. Biochemistry (Mosc) 39(38):11629\u201311639","journal-title":"Biochemistry (Mosc)"},{"key":"3078_CR25","doi-asserted-by":"publisher","first-page":"11482","DOI":"10.1038\/ncomms11482","volume":"7","author":"T Ritterhoff","year":"2016","unstructured":"Ritterhoff T, Das H, Hofhaus G, Schroder RR, Flotho A, Melchior F (2016) The RanBP2\/RanGAP1*SUMO1\/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes. Nat Commun 7:11482. https:\/\/doi.org\/10.1038\/ncomms11482","journal-title":"Nat Commun"},{"issue":"2","key":"3078_CR26","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1083\/jcb.140.2.259","volume":"140","author":"R Mahajan","year":"1998","unstructured":"Mahajan R, Gerace L, Melchior F (1998) Molecular characterization of the SUMO-1 modification of RanGAP1 and its role in nuclear envelope association. J Cell Biol 140(2):259\u2013270","journal-title":"J Cell Biol"},{"issue":"8","key":"3078_CR27","doi-asserted-by":"publisher","first-page":"3736","DOI":"10.1073\/pnas.94.8.3736","volume":"94","author":"H Saitoh","year":"1997","unstructured":"Saitoh H, Pu R, Cavenagh M, Dasso M (1997) RanBP2 associates with Ubc9p and a modified form of RanGAP1. Proc Natl Acad Sci USA 94(8):3736\u20133741","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6 Pt 1","key":"3078_CR28","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1083\/jcb.135.6.1457","volume":"135","author":"MJ Matunis","year":"1996","unstructured":"Matunis MJ, Coutavas E, Blobel G (1996) A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex. J Cell Biol 135(6 Pt 1):1457\u20131470","journal-title":"J Cell Biol"},{"issue":"1","key":"3078_CR29","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1083\/jcb.200202088","volume":"158","author":"TC Walther","year":"2002","unstructured":"Walther TC, Pickersgill HS, Cordes VC, Goldberg MW, Allen TD, Mattaj IW, Fornerod M (2002) The cytoplasmic filaments of the nuclear pore complex are dispensable for selective nuclear protein import. J Cell Biol 158(1):63\u201377","journal-title":"J Cell Biol"},{"issue":"4","key":"3078_CR30","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1083\/jcb.201102018","volume":"194","author":"M Hamada","year":"2011","unstructured":"Hamada M, Haeger A, Jeganathan KB, van Ree JH, Malureanu L, Walde S, Joseph J, Kehlenbach RH, van Deursen JM (2011) Ran-dependent docking of importin-beta to RanBP2\/Nup358 filaments is essential for protein import and cell viability. J Cell Biol 194(4):597\u2013612. https:\/\/doi.org\/10.1083\/jcb.201102018","journal-title":"J Cell Biol"},{"issue":"2","key":"3078_CR31","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1111\/j.1600-0854.2011.01302.x","volume":"13","author":"S Walde","year":"2012","unstructured":"Walde S, Thakar K, Hutten S, Spillner C, Nath A, Rothbauer U, Wiemann S, Kehlenbach RH (2012) The nucleoporin Nup358\/RanBP2 promotes nuclear import in a cargo- and transport receptor-specific manner. Traffic 13(2):218\u2013233. https:\/\/doi.org\/10.1111\/j.1600-0854.2011.01302.x","journal-title":"Traffic"},{"key":"3078_CR32","doi-asserted-by":"publisher","first-page":"29767","DOI":"10.1074\/jbc.M114.586834","volume":"298","author":"H Patil","year":"2014","unstructured":"Patil H, Saha A, Senda E, Cho KI, Haque M, Yu M, Qiu S, Yoon D, Hao Y, Peachey NS, Ferreira PA (2014) Selective impairment of a subset of Ran-GTP-binding domains of Ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation. J Biol Chem 298:29767\u201329789. https:\/\/doi.org\/10.1074\/jbc.M114.586834","journal-title":"J Biol Chem"},{"issue":"8","key":"3078_CR33","doi-asserted-by":"publisher","first-page":"4600","DOI":"10.1074\/jbc.M113.538215","volume":"289","author":"KI Cho","year":"2014","unstructured":"Cho KI, Patil H, Senda E, Wang J, Yi H, Qiu S, Yoon D, Yu M, Orry A, Peachey NS, Ferreira PA (2014) Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis. J Biol Chem 289(8):4600\u20134625. https:\/\/doi.org\/10.1074\/jbc.M113.538215","journal-title":"J Biol Chem"},{"issue":"5","key":"3078_CR34","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1242\/dmm.027730","volume":"10","author":"KI Cho","year":"2017","unstructured":"Cho KI, Yoon D, Qiu S, Danziger Z, Grill WM, Wetsel WC, Ferreira PA (2017) Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes. Dis Model Mech 10(5):559\u2013579. https:\/\/doi.org\/10.1242\/dmm.027730","journal-title":"Dis Model Mech"},{"issue":"9","key":"3078_CR35","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1034\/j.1600-0854.2002.30905.x","volume":"3","author":"TA Mavlyutov","year":"2002","unstructured":"Mavlyutov TA, Cai Y, Ferreira PA (2002) Identification of RanBP2- and kinesin-mediated transport pathways with restricted neuronal and subcellular localization. Traffic 3(9):630\u2013640","journal-title":"Traffic"},{"issue":"7442","key":"3078_CR36","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1038\/nature11922","volume":"495","author":"HJ Kim","year":"2013","unstructured":"Kim HJ, Kim NC, Wang YD, Scarborough EA, Moore J, Diaz Z, MacLea KS, Freibaum B, Li S, Molliex A, Kanagaraj AP, Carter R, Boylan KB, Wojtas AM, Rademakers R, Pinkus JL, Greenberg SA, Trojanowski JQ, Traynor BJ, Smith BN, Topp S, Gkazi AS, Miller J, Shaw CE, Kottlors M, Kirschner J, Pestronk A, Li YR, Ford AF, Gitler AD, Benatar M, King OD, Kimonis VE, Ross ED, Weihl CC, Shorter J, Taylor JP (2013) Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS. Nature 495(7442):467\u2013473. https:\/\/doi.org\/10.1038\/nature11922","journal-title":"Nature"},{"issue":"7295","key":"3078_CR37","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1038\/nature08971","volume":"465","author":"H Maruyama","year":"2010","unstructured":"Maruyama H, Morino H, Ito H, Izumi Y, Kato H, Watanabe Y, Kinoshita Y, Kamada M, Nodera H, Suzuki H, Komure O, Matsuura S, Kobatake K, Morimoto N, Abe K, Suzuki N, Aoki M, Kawata A, Hirai T, Kato T, Ogasawara K, Hirano A, Takumi T, Kusaka H, Hagiwara K, Kaji R, Kawakami H (2010) Mutations of optineurin in amyotrophic lateral sclerosis. Nature 465(7295):223\u2013226. https:\/\/doi.org\/10.1038\/nature08971","journal-title":"Nature"},{"issue":"11","key":"3078_CR38","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1136\/jnnp.2011.242313","volume":"82","author":"R Del Bo","year":"2011","unstructured":"Del Bo R, Tiloca C, Pensato V, Corrado L, Ratti A, Ticozzi N, Corti S, Castellotti B, Mazzini L, Soraru G, Cereda C, D\u2019Alfonso S, Gellera C, Comi GP, Silani V, Consortium S (2011) Novel optineurin mutations in patients with familial and sporadic amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry 82(11):1239\u20131243. https:\/\/doi.org\/10.1136\/jnnp.2011.242313","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"8","key":"3078_CR39","doi-asserted-by":"publisher","first-page":"2816","DOI":"10.1167\/iovs.04-1133","volume":"46","author":"T Aung","year":"2005","unstructured":"Aung T, Rezaie T, Okada K, Viswanathan AC, Child AH, Brice G, Bhattacharya SS, Lehmann OJ, Sarfarazi M, Hitchings RA (2005) Clinical features and course of patients with glaucoma with the E50K mutation in the optineurin gene. Invest Ophthalmol Vis Sci 46(8):2816\u20132822. https:\/\/doi.org\/10.1167\/iovs.04-1133","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5557","key":"3078_CR40","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1126\/science.1066901","volume":"295","author":"T Rezaie","year":"2002","unstructured":"Rezaie T, Child A, Hitchings R, Brice G, Miller L, Coca-Prados M, Heon E, Krupin T, Ritch R, Kreutzer D, Crick RP, Sarfarazi M (2002) Adult-onset primary open-angle glaucoma caused by mutations in optineurin. Science 295(5557):1077\u20131079. https:\/\/doi.org\/10.1126\/science.1066901","journal-title":"Science"},{"issue":"23","key":"3078_CR41","doi-asserted-by":"publisher","first-page":"16147","DOI":"10.1074\/jbc.M601467200","volume":"281","author":"N De Marco","year":"2006","unstructured":"De Marco N, Buono M, Troise F, Diez-Roux G (2006) Optineurin increases cell survival and translocates to the nucleus in a Rab8-dependent manner upon an apoptotic stimulus. J Biol Chem 281(23):16147\u201316156. https:\/\/doi.org\/10.1074\/jbc.M601467200","journal-title":"J Biol Chem"},{"issue":"4","key":"3078_CR42","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1007\/s004150050206","volume":"245","author":"TF Munte","year":"1998","unstructured":"Munte TF, Troger MC, Nusser I, Wieringa BM, Johannes S, Matzke M, Dengler R (1998) Alteration of early components of the visual evoked potential in amyotrophic lateral sclerosis. J Neurol 245(4):206\u2013210","journal-title":"J Neurol"},{"issue":"4","key":"3078_CR43","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1002\/acn3.46","volume":"1","author":"M Ringelstein","year":"2014","unstructured":"Ringelstein M, Albrecht P, Sudmeyer M, Harmel J, Muller AK, Keser N, Finis D, Ferrea S, Guthoff R, Schnitzler A, Hartung HP, Methner A, Aktas O (2014) Subtle retinal pathology in amyotrophic lateral sclerosis. Ann Clin Transl Neurol 1(4):290\u2013297. https:\/\/doi.org\/10.1002\/acn3.46","journal-title":"Ann Clin Transl Neurol"},{"issue":"3","key":"3078_CR44","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1007\/s00702-015-1483-4","volume":"123","author":"A Hubers","year":"2016","unstructured":"Hubers A, Muller HP, Dreyhaupt J, Bohm K, Lauda F, Tumani H, Kassubek J, Ludolph AC, Pinkhardt EH (2016) Retinal involvement in amyotrophic lateral sclerosis: a study with optical coherence tomography and diffusion tensor imaging. J Neural Transm (Vienna) 123(3):281\u2013287. https:\/\/doi.org\/10.1007\/s00702-015-1483-4","journal-title":"J Neural Transm (Vienna)"},{"key":"3078_CR45","doi-asserted-by":"publisher","first-page":"29187","DOI":"10.1038\/srep29187","volume":"6","author":"JM Simonett","year":"2016","unstructured":"Simonett JM, Huang R, Siddique N, Farsiu S, Siddique T, Volpe NJ, Fawzi AA (2016) Macular sub-layer thinning and association with pulmonary function tests in amyotrophic lateral sclerosis. Sci Rep 6:29187. https:\/\/doi.org\/10.1038\/srep29187","journal-title":"Sci Rep"},{"issue":"6","key":"3078_CR46","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1007\/s00401-017-1708-8","volume":"133","author":"J Nijssen","year":"2017","unstructured":"Nijssen J, Comley LH, Hedlund E (2017) Motor neuron vulnerability and resistance in amyotrophic lateral sclerosis. Acta Neuropathol 133(6):863\u2013885. https:\/\/doi.org\/10.1007\/s00401-017-1708-8","journal-title":"Acta Neuropathol"},{"issue":"6","key":"3078_CR47","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1038\/nn.2118","volume":"11","author":"P Young","year":"2008","unstructured":"Young P, Qiu L, Wang D, Zhao S, Gross J, Feng G (2008) Single-neuron labeling with inducible Cre-mediated knockout in transgenic mice. Nat Neurosci 11(6):721\u2013728. https:\/\/doi.org\/10.1038\/nn.2118","journal-title":"Nat Neurosci"},{"issue":"6","key":"3078_CR48","doi-asserted-by":"publisher","first-page":"e1003555","DOI":"10.1371\/journal.pgen.1003555","volume":"9","author":"KI Cho","year":"2013","unstructured":"Cho KI, Haque M, Wang J, Yu M, Hao Y, Qiu S, Pillai IC, Peachey NS, Ferreira PA (2013) Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors. PLoS Genet 9(6):e1003555. https:\/\/doi.org\/10.1371\/journal.pgen.1003555","journal-title":"PLoS Genet"},{"issue":"1","key":"3078_CR49","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.cell.2008.01.045","volume":"133","author":"MM Dawlaty","year":"2008","unstructured":"Dawlaty MM, Malureanu L, Jeganathan KB, Kao E, Sustmann C, Tahk S, Shuai K, Grosschedl R, van Deursen JM (2008) Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha. Cell 133(1):103\u2013115","journal-title":"Cell"},{"issue":"1","key":"3078_CR50","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.exer.2011.12.011","volume":"96","author":"M Yu","year":"2012","unstructured":"Yu M, Sturgill-Short G, Ganapathy P, Tawfik A, Peachey NS, Smith SB (2012) Age-related changes in visual function in cystathionine-beta-synthase mutant mice, a model of hyperhomocysteinemia. Exp Eye Res 96(1):124\u2013131. https:\/\/doi.org\/10.1016\/j.exer.2011.12.011","journal-title":"Exp Eye Res"},{"issue":"24","key":"3078_CR51","doi-asserted-by":"publisher","first-page":"14405","DOI":"10.1074\/jbc.270.24.14405","volume":"270","author":"SA Richards","year":"1995","unstructured":"Richards SA, Lounsbury KM, Macara IG (1995) The C terminus of the nuclear RAN\/TC4 GTPase stabilizes the GDP-bound state and mediates interactions with RCC1, RAN-GAP, and HTF9A\/RANBP1. J Biol Chem 270(24):14405\u201314411","journal-title":"J Biol Chem"},{"issue":"2","key":"3078_CR52","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1083\/jcb.130.2.265","volume":"130","author":"NC Chi","year":"1995","unstructured":"Chi NC, Adam EJ, Adam SA (1995) Sequence and characterization of cytoplasmic nuclear protein import factor p97. J Cell Biol 130(2):265\u2013274","journal-title":"J Cell Biol"},{"issue":"20","key":"3078_CR53","doi-asserted-by":"publisher","first-page":"3511","DOI":"10.1007\/s00018-012-1071-9","volume":"69","author":"KI Cho","year":"2012","unstructured":"Cho KI, Searle K, Webb M, Yi H, Ferreira PA (2012) Ranbp2 haploinsufficiency mediates distinct cellular and biochemical phenotypes in brain and retinal dopaminergic and glia cells elicited by the Parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Cell Mol Life Sci 69(20):3511\u20133527. https:\/\/doi.org\/10.1007\/s00018-012-1071-9","journal-title":"Cell Mol Life Sci"},{"issue":"9\u201310","key":"3078_CR54","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1242\/dmm.004648","volume":"3","author":"KI Cho","year":"2010","unstructured":"Cho KI, Yi H, Tserentsoodol N, Searle K, Ferreira PA (2010) Neuroprotection resulting from insufficiency of RANBP2 is associated with the modulation of protein and lipid homeostasis of functionally diverse but linked pathways in response to oxidative stress. Dis Model Mech 3(9\u201310):595\u2013604. https:\/\/doi.org\/10.1242\/dmm.004648","journal-title":"Dis Model Mech"},{"issue":"2","key":"3078_CR55","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1038\/cdd.2008.153","volume":"16","author":"KI Cho","year":"2009","unstructured":"Cho KI, Yi H, Yeh A, Tserentsoodol N, Cuadrado L, Searle K, Hao Y, Ferreira PA (2009) Haploinsufficiency of RanBP2 is neuroprotective against light-elicited and age-dependent degeneration of photoreceptor neurons. Cell Death Differ 16(2):287\u2013297. https:\/\/doi.org\/10.1038\/cdd.2008.153","journal-title":"Cell Death Differ"},{"issue":"3","key":"3078_CR56","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1038\/nprot.2012.016","volume":"7","author":"C Trapnell","year":"2012","unstructured":"Trapnell C, Roberts A, Goff L, Pertea G, Kim D, Kelley DR, Pimentel H, Salzberg SL, Rinn JL, Pachter L (2012) Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks. Nat Protoc 7(3):562\u2013578. https:\/\/doi.org\/10.1038\/nprot.2012.016","journal-title":"Nat Protoc"},{"issue":"47","key":"3078_CR57","doi-asserted-by":"publisher","first-page":"28097","DOI":"10.1074\/jbc.M115.680090","volume":"290","author":"L Chen","year":"2015","unstructured":"Chen L, Hambright WS, Na R, Ran Q (2015) Ablation of the ferroptosis inhibitor glutathione peroxidase 4 in neurons results in rapid motor neuron degeneration and paralysis. J Biol Chem 290(47):28097\u201328106. https:\/\/doi.org\/10.1074\/jbc.M115.680090","journal-title":"J Biol Chem"},{"issue":"1","key":"3078_CR58","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/s13024-016-0132-1","volume":"11","author":"C Altmann","year":"2016","unstructured":"Altmann C, Vasic V, Hardt S, Heidler J, Haussler A, Wittig I, Schmidt MHH, Tegeder I (2016) Progranulin promotes peripheral nerve regeneration and reinnervation: role of notch signaling. Mol Neurodegener 11(1):69. https:\/\/doi.org\/10.1186\/s13024-016-0132-1","journal-title":"Mol Neurodegener"},{"issue":"3","key":"3078_CR59","doi-asserted-by":"publisher","first-page":"175909141559306","DOI":"10.1177\/1759091415593066","volume":"7","author":"F Lebrun-Julien","year":"2015","unstructured":"Lebrun-Julien F, Suter U (2015) Combined HDAC1 and HDAC2 depletion promotes retinal ganglion cell survival after injury through reduction of p53 target gene expression. ASN Neuro 7(3):1759091415593066. https:\/\/doi.org\/10.1177\/1759091415593066","journal-title":"ASN Neuro"},{"issue":"4","key":"3078_CR60","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1017\/S0952523800012591","volume":"14","author":"NS Peachey","year":"1997","unstructured":"Peachey NS, Roveri L, Messing A, McCall MA (1997) Functional consequences of oncogene-induced horizontal cell degeneration in the retinas of transgenic mice. Vis Neurosci 14(4):627\u2013632","journal-title":"Vis Neurosci"},{"issue":"6\u20137","key":"3078_CR61","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1016\/j.visres.2005.09.006","volume":"46","author":"WH Ridder 3rd","year":"2006","unstructured":"Ridder WH 3rd, Nusinowitz S (2006) The visual evoked potential in the mouse\u2014origins and response characteristics. Vision Res 46(6\u20137):902\u2013913. https:\/\/doi.org\/10.1016\/j.visres.2005.09.006","journal-title":"Vision Res"},{"issue":"5","key":"3078_CR62","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1016\/j.exer.2011.07.004","volume":"93","author":"AR Barnard","year":"2011","unstructured":"Barnard AR, Charbel Issa P, Perganta G, Williams PA, Davies VJ, Sekaran S, Votruba M, MacLaren RE (2011) Specific deficits in visual electrophysiology in a mouse model of dominant optic atrophy. Exp Eye Res 93(5):771\u2013777. https:\/\/doi.org\/10.1016\/j.exer.2011.07.004","journal-title":"Exp Eye Res"},{"issue":"4","key":"3078_CR63","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1007\/BF00687339","volume":"63","author":"JH O\u2019Neill","year":"1984","unstructured":"O\u2019Neill JH, Jacobs JM, Gilliatt RW, Baba M (1984) Changes in the compact myelin of single internodes during axonal atrophy. Acta Neuropathol 63(4):313\u2013318","journal-title":"Acta Neuropathol"},{"key":"3078_CR64","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1038\/srep01138","volume":"3","author":"S Soma","year":"2013","unstructured":"Soma S, Shimegi S, Suematsu N, Sato H (2013) Cholinergic modulation of response gain in the rat primary visual cortex. Sci Rep 3:1138. https:\/\/doi.org\/10.1038\/srep01138","journal-title":"Sci Rep"},{"issue":"11","key":"3078_CR65","doi-asserted-by":"publisher","first-page":"2682","DOI":"10.1093\/emboj\/21.11.2682","volume":"21","author":"O Kirsh","year":"2002","unstructured":"Kirsh O, Seeler JS, Pichler A, Gast A, Muller S, Miska E, Mathieu M, Harel-Bellan A, Kouzarides T, Melchior F, Dejean A (2002) The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase. EMBO J 21(11):2682\u20132691. https:\/\/doi.org\/10.1093\/emboj\/21.11.2682","journal-title":"EMBO J"},{"issue":"10","key":"3078_CR66","doi-asserted-by":"publisher","first-page":"2030","DOI":"10.1016\/j.bbamcr.2008.07.007","volume":"1783","author":"A Scognamiglio","year":"2008","unstructured":"Scognamiglio A, Nebbioso A, Manzo F, Valente S, Mai A, Altucci L (2008) HDAC-class II specific inhibition involves HDAC proteasome-dependent degradation mediated by RANBP2. Biochim Biophys Acta 1783(10):2030\u20132038. https:\/\/doi.org\/10.1016\/j.bbamcr.2008.07.007","journal-title":"Biochim Biophys Acta"},{"issue":"5","key":"3078_CR67","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1677\/JME-08-0176","volume":"43","author":"Y Tong","year":"2009","unstructured":"Tong Y, Eigler T (2009) Transcriptional targets for pituitary tumor-transforming gene-1. J Mol Endocrinol 43(5):179\u2013185. https:\/\/doi.org\/10.1677\/JME-08-0176","journal-title":"J Mol Endocrinol"},{"key":"3078_CR68","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1016\/S0021-9258(18)60223-6","volume":"237","author":"M Waite","year":"1962","unstructured":"Waite M, Wakil SJ (1962) Studies on the mechanism of fatty acid synthesis. XII. Acetyl coenzyme A carboxylase. J Biol Chem 237:2750\u20132757","journal-title":"J Biol Chem"},{"issue":"Pt 2","key":"3078_CR69","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1042\/BST20060223","volume":"34","author":"RW Brownsey","year":"2006","unstructured":"Brownsey RW, Boone AN, Elliott JE, Kulpa JE, Lee WM (2006) Regulation of acetyl-CoA carboxylase. Biochem Soc Trans 34(Pt 2):223\u2013227. https:\/\/doi.org\/10.1042\/BST20060223","journal-title":"Biochem Soc Trans"},{"issue":"7","key":"3078_CR70","doi-asserted-by":"publisher","first-page":"3190","DOI":"10.4049\/jimmunol.1302985","volume":"192","author":"J Lee","year":"2014","unstructured":"Lee J, Walsh MC, Hoehn KL, James DE, Wherry EJ, Choi Y (2014) Regulator of fatty acid metabolism, acetyl coenzyme a carboxylase 1, controls T cell immunity. J Immunol 192(7):3190\u20133199. https:\/\/doi.org\/10.4049\/jimmunol.1302985","journal-title":"J Immunol"},{"issue":"11","key":"3078_CR71","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1038\/nm.3704","volume":"20","author":"L Berod","year":"2014","unstructured":"Berod L, Friedrich C, Nandan A, Freitag J, Hagemann S, Harmrolfs K, Sandouk A, Hesse C, Castro CN, Bahre H, Tschirner SK, Gorinski N, Gohmert M, Mayer CT, Huehn J, Ponimaskin E, Abraham WR, Muller R, Lochner M, Sparwasser T (2014) De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells. Nat Med 20(11):1327\u20131333. https:\/\/doi.org\/10.1038\/nm.3704","journal-title":"Nat Med"},{"issue":"5","key":"3078_CR72","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1038\/nn.4528","volume":"20","author":"Y Dombrowski","year":"2017","unstructured":"Dombrowski Y, O\u2019Hagan T, Dittmer M, Penalva R, Mayoral SR, Bankhead P, Fleville S, Eleftheriadis G, Zhao C, Naughton M, Hassan R, Moffat J, Falconer J, Boyd A, Hamilton P, Allen IV, Kissenpfennig A, Moynagh PN, Evergren E, Perbal B, Williams AC, Ingram RJ, Chan JR, Franklin RJM, Fitzgerald DC (2017) Regulatory T cells promote myelin regeneration in the central nervous system. Nat Neurosci 20(5):674\u2013680. https:\/\/doi.org\/10.1038\/nn.4528","journal-title":"Nat Neurosci"},{"issue":"2","key":"3078_CR73","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1152\/physrev.00011.2010","volume":"91","author":"H Kettenmann","year":"2011","unstructured":"Kettenmann H, Hanisch UK, Noda M, Verkhratsky A (2011) Physiology of microglia. Physiol Rev 91(2):461\u2013553. https:\/\/doi.org\/10.1152\/physrev.00011.2010","journal-title":"Physiol Rev"},{"issue":"5","key":"3078_CR74","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1038\/nrn3722","volume":"15","author":"M Prinz","year":"2014","unstructured":"Prinz M, Priller J (2014) Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease. Nat Rev Neurosci 15(5):300\u2013312. https:\/\/doi.org\/10.1038\/nrn3722","journal-title":"Nat Rev Neurosci"},{"issue":"9","key":"3078_CR75","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.15252\/emmm.201505298","volume":"7","author":"L Zhao","year":"2015","unstructured":"Zhao L, Zabel MK, Wang X, Ma W, Shah P, Fariss RN, Qian H, Parkhurst CN, Gan WB, Wong WT (2015) Microglial phagocytosis of living photoreceptors contributes to inherited retinal degeneration. EMBO Mol Med 7(9):1179\u20131197. https:\/\/doi.org\/10.15252\/emmm.201505298","journal-title":"EMBO Mol Med"},{"issue":"6","key":"3078_CR76","doi-asserted-by":"publisher","first-page":"3866","DOI":"10.4049\/jimmunol.0713949","volume":"182","author":"AM Manicone","year":"2009","unstructured":"Manicone AM, Birkland TP, Lin M, Betsuyaku T, van Rooijen N, Lohi J, Keski-Oja J, Wang Y, Skerrett SJ, Parks WC (2009) Epilysin (MMP-28) restrains early macrophage recruitment in Pseudomonas aeruginosa pneumonia. J Immunol 182(6):3866\u20133876. https:\/\/doi.org\/10.4049\/jimmunol.0713949","journal-title":"J Immunol"},{"issue":"1","key":"3078_CR77","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1189\/jlb.1112587","volume":"95","author":"SA Gharib","year":"2014","unstructured":"Gharib SA, Johnston LK, Huizar I, Birkland TP, Hanson J, Wang Y, Parks WC, Manicone AM (2014) MMP28 promotes macrophage polarization toward M2 cells and augments pulmonary fibrosis. J Leukoc Biol 95(1):9\u201318. https:\/\/doi.org\/10.1189\/jlb.1112587","journal-title":"J Leukoc Biol"},{"issue":"6","key":"3078_CR78","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1177\/1753425918791024","volume":"24","author":"ME Long","year":"2018","unstructured":"Long ME, Gong KQ, Volk JS, Eddy WE, Chang MY, Frevert CW, Altemeier WA, Gale M Jr, Liles WC, Manicone AM (2018) Matrix metalloproteinase 28 is regulated by TRIF- and type I IFN-dependent signaling in macrophages. Innate Immun 24(6):357\u2013365. https:\/\/doi.org\/10.1177\/1753425918791024","journal-title":"Innate Immun"},{"key":"3078_CR79","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1186\/1471-2202-9-83","volume":"9","author":"SR Werner","year":"2008","unstructured":"Werner SR, Dotzlaf JE, Smith RC (2008) MMP-28 as a regulator of myelination. BMC Neurosci 9:83. https:\/\/doi.org\/10.1186\/1471-2202-9-83","journal-title":"BMC Neurosci"},{"issue":"3","key":"3078_CR80","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.pneurobio.2009.07.006","volume":"89","author":"DH Smith","year":"2009","unstructured":"Smith DH (2009) Stretch growth of integrated axon tracts: extremes and exploitations. Prog Neurobiol 89(3):231\u2013239. https:\/\/doi.org\/10.1016\/j.pneurobio.2009.07.006","journal-title":"Prog Neurobiol"},{"issue":"5","key":"3078_CR81","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1093\/hmg\/ddu545","volume":"24","author":"HM Kaneb","year":"2015","unstructured":"Kaneb HM, Folkmann AW, Belzil VV, Jao LE, Leblond CS, Girard SL, Daoud H, Noreau A, Rochefort D, Hince P, Szuto A, Levert A, Vidal S, Andre-Guimont C, Camu W, Bouchard JP, Dupre N, Rouleau GA, Wente SR, Dion PA (2015) Deleterious mutations in the essential mRNA metabolism factor, hGle1, in amyotrophic lateral sclerosis. Hum Mol Genet 24(5):1363\u20131373. https:\/\/doi.org\/10.1093\/hmg\/ddu545","journal-title":"Hum Mol Genet"},{"issue":"3","key":"3078_CR82","doi-asserted-by":"publisher","first-page":"120183","DOI":"10.1098\/rsob.120183","volume":"3","author":"H Patil","year":"2013","unstructured":"Patil H, Cho KI, Lee J, Yang Y, Orry A, Ferreira PA (2013) Kinesin-1 and mitochondrial motility control by discrimination of structurally equivalent but distinct subdomains in Ran-GTP-binding domains of Ran-binding protein 2. Open Biol 3(3):120183. https:\/\/doi.org\/10.1098\/rsob.120183","journal-title":"Open Biol"},{"issue":"5","key":"3078_CR83","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1038\/embor.2009.29","volume":"10","author":"KI Cho","year":"2009","unstructured":"Cho KI, Yi H, Desai R, Hand AR, Haas AL, Ferreira PA (2009) RANBP2 is an allosteric activator of the conventional kinesin-1 motor protein, KIF5B, in a minimal cell-free system. EMBO Rep 10(5):480\u2013486. https:\/\/doi.org\/10.1038\/embor.2009.29","journal-title":"EMBO Rep"},{"key":"3078_CR84","doi-asserted-by":"publisher","first-page":"1722","DOI":"10.1111\/j.1600-0854.2007.00647.x","volume":"8","author":"KI Cho","year":"2007","unstructured":"Cho KI, Cai Y, Yi H, Yeh A, Aslanukov A, Ferreira PA (2007) Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function. Traffic 8:1722\u20131735","journal-title":"Traffic"},{"issue":"45","key":"3078_CR85","doi-asserted-by":"publisher","first-page":"41594","DOI":"10.1074\/jbc.M104514200","volume":"276","author":"Y Cai","year":"2001","unstructured":"Cai Y, Singh BB, Aslanukov A, Zhao H, Ferreira PA (2001) The docking of kinesins, KIF5B and KIF5C, to Ran-binding protein 2 (RanBP2) is mediated via a novel RanBP2 domain. J Biol Chem 276(45):41594\u201341602","journal-title":"J Biol Chem"},{"issue":"11","key":"3078_CR86","doi-asserted-by":"publisher","first-page":"e0166732","DOI":"10.1371\/journal.pone.0166732","volume":"11","author":"F Yoshikawa","year":"2016","unstructured":"Yoshikawa F, Sato Y, Tohyama K, Akagi T, Furuse T, Sadakata T, Tanaka M, Shinoda Y, Hashikawa T, Itohara S, Sano Y, Ghandour MS, Wakana S, Furuichi T (2016) Mammalian-specific central myelin protein opalin is redundant for normal myelination: structural and behavioral assessments. PLoS One 11(11):e0166732. https:\/\/doi.org\/10.1371\/journal.pone.0166732","journal-title":"PLoS One"},{"issue":"5","key":"3078_CR87","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1016\/S0161-6420(00)00644-8","volume":"108","author":"V Parisi","year":"2001","unstructured":"Parisi V, Manni G, Centofanti M, Gandolfi SA, Olzi D, Bucci MG (2001) Correlation between optical coherence tomography, pattern electroretinogram, and visual evoked potentials in open-angle glaucoma patients. Ophthalmology 108(5):905\u2013912","journal-title":"Ophthalmology"},{"issue":"2","key":"3078_CR88","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/S1388-2457(00)00525-3","volume":"112","author":"V Parisi","year":"2001","unstructured":"Parisi V (2001) Impaired visual function in glaucoma. Clin Neurophysiol 112(2):351\u2013358","journal-title":"Clin Neurophysiol"},{"issue":"1","key":"3078_CR89","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1093\/brain\/99.1.43","volume":"99","author":"D Regan","year":"1976","unstructured":"Regan D, Milner BA, Heron JR (1976) Delayed visual perception and delayed visual evoked potentials in the spinal form of multiple sclerosis and in retrobulbar neuritis. Brain 99(1):43\u201366","journal-title":"Brain"},{"issue":"11","key":"3078_CR90","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1038\/sj.eye.6701573","volume":"18","author":"GE Holder","year":"2004","unstructured":"Holder GE (2004) Electrophysiological assessment of optic nerve disease. Eye (Lond) 18(11):1133\u20131143. https:\/\/doi.org\/10.1038\/sj.eye.6701573","journal-title":"Eye (Lond)"},{"issue":"1","key":"3078_CR91","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1097\/WCO.0b013e328320264c","volume":"22","author":"GE Holder","year":"2009","unstructured":"Holder GE, Gale RP, Acheson JF, Robson AG (2009) Electrodiagnostic assessment in optic nerve disease. Curr Opin Neurol 22(1):3\u201310. https:\/\/doi.org\/10.1097\/WCO.0b013e328320264c","journal-title":"Curr Opin Neurol"},{"issue":"2","key":"3078_CR92","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.celrep.2013.06.018","volume":"4","author":"IM Chiu","year":"2013","unstructured":"Chiu IM, Morimoto ET, Goodarzi H, Liao JT, O\u2019Keeffe S, Phatnani HP, Muratet M, Carroll MC, Levy S, Tavazoie S, Myers RM, Maniatis T (2013) A neurodegeneration-specific gene-expression signature of acutely isolated microglia from an amyotrophic lateral sclerosis mouse model. Cell Rep 4(2):385\u2013401. https:\/\/doi.org\/10.1016\/j.celrep.2013.06.018","journal-title":"Cell Rep"},{"key":"3078_CR93","doi-asserted-by":"publisher","first-page":"12143","DOI":"10.1038\/ncomms12143","volume":"7","author":"K Kapeli","year":"2016","unstructured":"Kapeli K, Pratt GA, Vu AQ, Hutt KR, Martinez FJ, Sundararaman B, Batra R, Freese P, Lambert NJ, Huelga SC, Chun SJ, Liang TY, Chang J, Donohue JP, Shiue L, Zhang J, Zhu H, Cambi F, Kasarskis E, Hoon S, Ares M Jr, Burge CB, Ravits J, Rigo F, Yeo GW (2016) Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses. Nat Commun 7:12143. https:\/\/doi.org\/10.1038\/ncomms12143","journal-title":"Nat Commun"},{"issue":"11","key":"3078_CR94","doi-asserted-by":"publisher","first-page":"1488","DOI":"10.1038\/nn.3230","volume":"15","author":"C Lagier-Tourenne","year":"2012","unstructured":"Lagier-Tourenne C, Polymenidou M, Hutt KR, Vu AQ, Baughn M, Huelga SC, Clutario KM, Ling SC, Liang TY, Mazur C, Wancewicz E, Kim AS, Watt A, Freier S, Hicks GG, Donohue JP, Shiue L, Bennett CF, Ravits J, Cleveland DW, Yeo GW (2012) Divergent roles of ALS-linked proteins FUS\/TLS and TDP-43 intersect in processing long pre-mRNAs. Nat Neurosci 15(11):1488\u20131497. https:\/\/doi.org\/10.1038\/nn.3230","journal-title":"Nat Neurosci"},{"issue":"4","key":"3078_CR95","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1038\/nn.2779","volume":"14","author":"M Polymenidou","year":"2011","unstructured":"Polymenidou M, Lagier-Tourenne C, Hutt KR, Huelga SC, Moran J, Liang TY, Ling SC, Sun E, Wancewicz E, Mazur C, Kordasiewicz H, Sedaghat Y, Donohue JP, Shiue L, Bennett CF, Yeo GW, Cleveland DW (2011) Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43. Nat Neurosci 14(4):459\u2013468. https:\/\/doi.org\/10.1038\/nn.2779","journal-title":"Nat Neurosci"},{"issue":"4","key":"3078_CR96","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1016\/j.neuron.2016.09.050","volume":"92","author":"FJ Martinez","year":"2016","unstructured":"Martinez FJ, Pratt GA, Van Nostrand EL, Batra R, Huelga SC, Kapeli K, Freese P, Chun SJ, Ling K, Gelboin-Burkhart C, Fijany L, Wang HC, Nussbacher JK, Broski SM, Kim HJ, Lardelli R, Sundararaman B, Donohue JP, Javaherian A, Lykke-Andersen J, Finkbeiner S, Bennett CF, Ares M Jr, Burge CB, Taylor JP, Rigo F, Yeo GW (2016) Protein-RNA networks regulated by normal and ALS-associated mutant HNRNPA2B1 in the nervous system. Neuron 92(4):780\u2013795. https:\/\/doi.org\/10.1016\/j.neuron.2016.09.050","journal-title":"Neuron"},{"key":"3078_CR97","doi-asserted-by":"publisher","first-page":"44500","DOI":"10.1038\/srep44500","volume":"7","author":"N Rotem","year":"2017","unstructured":"Rotem N, Magen I, Ionescu A, Gershoni-Emek N, Altman T, Costa CJ, Gradus T, Pasmanik-Chor M, Willis DE, Ben-Dov IZ, Hornstein E, Perlson E (2017) ALS along the axons\u2014expression of coding and noncoding RNA differs in axons of ALS models. Sci Rep 7:44500. https:\/\/doi.org\/10.1038\/srep44500","journal-title":"Sci Rep"},{"issue":"1","key":"3078_CR98","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1007\/s00401-012-1058-5","volume":"125","author":"A Brockington","year":"2013","unstructured":"Brockington A, Ning K, Heath PR, Wood E, Kirby J, Fusi N, Lawrence N, Wharton SB, Ince PG, Shaw PJ (2013) Unravelling the enigma of selective vulnerability in neurodegeneration: motor neurons resistant to degeneration in ALS show distinct gene expression characteristics and decreased susceptibility to excitotoxicity. Acta Neuropathol 125(1):95\u2013109. https:\/\/doi.org\/10.1007\/s00401-012-1058-5","journal-title":"Acta Neuropathol"},{"issue":"Pt A","key":"3078_CR99","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.brainres.2015.09.025","volume":"1641","author":"CC Stolt","year":"2016","unstructured":"Stolt CC, Wegner M (2016) Schwann cells and their transcriptional network: evolution of key regulators of peripheral myelination. Brain Res 1641(Pt A):101\u2013110. https:\/\/doi.org\/10.1016\/j.brainres.2015.09.025","journal-title":"Brain Res"},{"issue":"30","key":"3078_CR100","doi-asserted-by":"publisher","first-page":"20830","DOI":"10.1074\/jbc.M801314200","volume":"283","author":"F Yoshikawa","year":"2008","unstructured":"Yoshikawa F, Sato Y, Tohyama K, Akagi T, Hashikawa T, Nagakura-Takagi Y, Sekine Y, Morita N, Baba H, Suzuki Y, Sugano S, Sato A, Furuichi T (2008) Opalin, a transmembrane sialylglycoprotein located in the central nervous system myelin paranodal loop membrane. J Biol Chem 283(30):20830\u201320840. https:\/\/doi.org\/10.1074\/jbc.M801314200","journal-title":"J Biol Chem"},{"issue":"1","key":"3078_CR101","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1523\/JNEUROSCI.4178-07.2008","volume":"28","author":"JD Cahoy","year":"2008","unstructured":"Cahoy JD, Emery B, Kaushal A, Foo LC, Zamanian JL, Christopherson KS, Xing Y, Lubischer JL, Krieg PA, Krupenko SA, Thompson WJ, Barres BA (2008) A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function. J Neurosci 28(1):264\u2013278. https:\/\/doi.org\/10.1523\/JNEUROSCI.4178-07.2008","journal-title":"J Neurosci"},{"issue":"7","key":"3078_CR102","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.1016\/j.neurobiolaging.2012.11.016","volume":"34","author":"E Milanesi","year":"2013","unstructured":"Milanesi E, Bonvicini C, Alberici A, Pilotto A, Cattane N, Premi E, Gazzina S, Archetti S, Gasparotti R, Cancelli V, Gennarelli M, Padovani A, Borroni B (2013) Molecular signature of disease onset in granulin mutation carriers: a gene expression analysis study. Neurobiol Aging 34(7):1837\u20131845. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2012.11.016","journal-title":"Neurobiol Aging"},{"issue":"11","key":"3078_CR103","doi-asserted-by":"publisher","first-page":"2355","DOI":"10.1016\/j.febslet.2005.03.032","volume":"579","author":"EC de Vet","year":"2005","unstructured":"de Vet EC, Newland SA, Lyons PA, Aguado B, Campbell RD (2005) The cell surface receptor G6b, a member of the immunoglobulin superfamily, binds heparin. FEBS Lett 579(11):2355\u20132358. https:\/\/doi.org\/10.1016\/j.febslet.2005.03.032","journal-title":"FEBS Lett"},{"issue":"2","key":"3078_CR104","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.cmet.2013.05.017","volume":"18","author":"E Currie","year":"2013","unstructured":"Currie E, Schulze A, Zechner R, Walther TC, Farese RV Jr (2013) Cellular fatty acid metabolism and cancer. Cell Metab 18(2):153\u2013161. https:\/\/doi.org\/10.1016\/j.cmet.2013.05.017","journal-title":"Cell Metab"},{"issue":"18","key":"3078_CR105","doi-asserted-by":"publisher","first-page":"E3719","DOI":"10.1073\/pnas.1617721114","volume":"114","author":"DT White","year":"2017","unstructured":"White DT, Sengupta S, Saxena MT, Xu Q, Hanes J, Ding D, Ji H, Mumm JS (2017) Immunomodulation-accelerated neuronal regeneration following selective rod photoreceptor cell ablation in the zebrafish retina. Proc Natl Acad Sci USA 114(18):E3719\u2013E3728. https:\/\/doi.org\/10.1073\/pnas.1617721114","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"3078_CR106","doi-asserted-by":"publisher","first-page":"eaap8492","DOI":"10.1126\/sciadv.aap8492","volume":"4","author":"Y Zhang","year":"2018","unstructured":"Zhang Y, Zhao L, Wang X, Ma W, Lazere A, Qian HH, Zhang J, Abu-Asab M, Fariss RN, Roger JE, Wong WT (2018) Repopulating retinal microglia restore endogenous organization and function under CX3CL1-CX3CR1 regulation. Sci Adv 4(3):eaap8492. https:\/\/doi.org\/10.1126\/sciadv.aap8492","journal-title":"Sci Adv"},{"issue":"11","key":"3078_CR107","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1002\/glia.20535","volume":"55","author":"H Xu","year":"2007","unstructured":"Xu H, Chen M, Mayer EJ, Forrester JV, Dick AD (2007) Turnover of resident retinal microglia in the normal adult mouse. Glia 55(11):1189\u20131198. https:\/\/doi.org\/10.1002\/glia.20535","journal-title":"Glia"},{"issue":"9","key":"3078_CR108","doi-asserted-by":"publisher","first-page":"4831","DOI":"10.1167\/iovs.09-4923","volume":"51","author":"PS Muther","year":"2010","unstructured":"Muther PS, Semkova I, Schmidt K, Abari E, Kuebbeler M, Beyer M, Abken H, Meyer KL, Kociok N, Joussen AM (2010) Conditions of retinal glial and inflammatory cell activation after irradiation in a GFP-chimeric mouse model. Invest Ophthalmol Vis Sci 51(9):4831\u20134839. https:\/\/doi.org\/10.1167\/iovs.09-4923","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"3078_CR109","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.neuron.2013.12.009","volume":"81","author":"A Kaplan","year":"2014","unstructured":"Kaplan A, Spiller KJ, Towne C, Kanning KC, Choe GT, Geber A, Akay T, Aebischer P, Henderson CE (2014) Neuronal matrix metalloproteinase-9 is a determinant of selective neurodegeneration. Neuron 81(2):333\u2013348. https:\/\/doi.org\/10.1016\/j.neuron.2013.12.009","journal-title":"Neuron"},{"issue":"1","key":"3078_CR110","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.expneurol.2007.01.036","volume":"205","author":"M Kiaei","year":"2007","unstructured":"Kiaei M, Kipiani K, Calingasan NY, Wille E, Chen J, Heissig B, Rafii S, Lorenzl S, Beal MF (2007) Matrix metalloproteinase-9 regulates TNF-alpha and FasL expression in neuronal, glial cells and its absence extends life in a transgenic mouse model of amyotrophic lateral sclerosis. Exp Neurol 205(1):74\u201381. https:\/\/doi.org\/10.1016\/j.expneurol.2007.01.036","journal-title":"Exp Neurol"},{"issue":"6","key":"3078_CR111","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1016\/j.ajpath.2017.02.008","volume":"187","author":"AM Manicone","year":"2017","unstructured":"Manicone AM, Gharib SA, Gong KQ, Eddy WE, Long ME, Frevert CW, Altemeier WA, Parks WC, Houghton AM (2017) Matrix metalloproteinase-28 is a key contributor to emphysema pathogenesis. Am J Pathol 187(6):1288\u20131300. https:\/\/doi.org\/10.1016\/j.ajpath.2017.02.008","journal-title":"Am J Pathol"},{"issue":"4","key":"3078_CR112","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1038\/ni.2833","volume":"15","author":"B Everts","year":"2014","unstructured":"Everts B, Amiel E, Huang SC, Smith AM, Chang CH, Lam WY, Redmann V, Freitas TC, Blagih J, van der Windt GJ, Artyomov MN, Jones RG, Pearce EL, Pearce EJ (2014) TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKvarepsilon supports the anabolic demands of dendritic cell activation. Nat Immunol 15(4):323\u2013332. https:\/\/doi.org\/10.1038\/ni.2833","journal-title":"Nat Immunol"},{"issue":"7","key":"3078_CR113","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1006\/cyto.1998.0436","volume":"11","author":"Y Wu","year":"1999","unstructured":"Wu Y, Prystowsky MB, Orlofsky A (1999) Sustained high-level production of murine chemokine C10 during chronic inflammation. Cytokine 11(7):523\u2013530. https:\/\/doi.org\/10.1006\/cyto.1998.0436","journal-title":"Cytokine"},{"issue":"4","key":"3078_CR114","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1016\/S0002-9440(10)65370-9","volume":"154","author":"VC Asensio","year":"1999","unstructured":"Asensio VC, Lassmann S, Pagenstecher A, Steffensen SC, Henriksen SJ, Campbell IL (1999) C10 is a novel chemokine expressed in experimental inflammatory demyelinating disorders that promotes recruitment of macrophages to the central nervous system. Am J Pathol 154(4):1181\u20131191. https:\/\/doi.org\/10.1016\/S0002-9440(10)65370-9","journal-title":"Am J Pathol"},{"issue":"1\u20132","key":"3078_CR115","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.jneuroim.2005.06.028","volume":"167","author":"M Kanno","year":"2005","unstructured":"Kanno M, Suzuki S, Fujiwara T, Yokoyama A, Sakamoto A, Takahashi H, Imai Y, Tanaka J (2005) Functional expression of CCL6 by rat microglia: a possible role of CCL6 in cell-cell communication. J Neuroimmunol 167(1\u20132):72\u201380. https:\/\/doi.org\/10.1016\/j.jneuroim.2005.06.028","journal-title":"J Neuroimmunol"},{"issue":"3","key":"3078_CR116","doi-asserted-by":"publisher","first-page":"321","DOI":"10.3892\/br.2014.243","volume":"2","author":"H Nakajima","year":"2014","unstructured":"Nakajima H, Koizumi K (2014) Family with sequence similarity 107: a family of stress responsive small proteins with diverse functions in cancer and the nervous system (Review). Biomed Rep 2(3):321\u2013325. https:\/\/doi.org\/10.3892\/br.2014.243","journal-title":"Biomed Rep"},{"issue":"33","key":"3078_CR117","doi-asserted-by":"publisher","first-page":"4636","DOI":"10.1038\/onc.2010.216","volume":"29","author":"PU Le","year":"2010","unstructured":"Le PU, Angers-Loustau A, de Oliveira RM, Ajlan A, Brassard CL, Dudley A, Brent H, Siu V, Trinh G, Molenkamp G, Wang J, Seyed Sadr M, Bedell B, Del Maestro RF, Petrecca K (2010) DRR drives brain cancer invasion by regulating cytoskeletal-focal adhesion dynamics. Oncogene 29(33):4636\u20134647. https:\/\/doi.org\/10.1038\/onc.2010.216","journal-title":"Oncogene"},{"issue":"22","key":"3078_CR118","doi-asserted-by":"publisher","first-page":"4302","DOI":"10.1091\/mbc.E10-10-0838","volume":"22","author":"MA Moreno-Mateos","year":"2011","unstructured":"Moreno-Mateos MA, Espina AG, Torres B, Gamez del Estal MM, Romero-Franco A, Rios RM, Pintor-Toro JA (2011) PTTG1\/securin modulates microtubule nucleation and cell migration. Mol Biol Cell 22(22):4302\u20134311. https:\/\/doi.org\/10.1091\/mbc.E10-10-0838","journal-title":"Mol Biol Cell"},{"issue":"6","key":"3078_CR119","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1007\/s00018-013-1480-4","volume":"71","author":"F Rizzo","year":"2014","unstructured":"Rizzo F, Riboldi G, Salani S, Nizzardo M, Simone C, Corti S, Hedlund E (2014) Cellular therapy to target neuroinflammation in amyotrophic lateral sclerosis. Cell Mol Life Sci 71(6):999\u20131015. https:\/\/doi.org\/10.1007\/s00018-013-1480-4","journal-title":"Cell Mol Life Sci"},{"issue":"6279","key":"3078_CR120","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1126\/science.aaf1064","volume":"351","author":"JG O\u2019Rourke","year":"2016","unstructured":"O\u2019Rourke JG, Bogdanik L, Yanez A, Lall D, Wolf AJ, Muhammad AK, Ho R, Carmona S, Vit JP, Zarrow J, Kim KJ, Bell S, Harms MB, Miller TM, Dangler CA, Underhill DM, Goodridge HS, Lutz CM, Baloh RH (2016) C9orf72 is required for proper macrophage and microglial function in mice. Science 351(6279):1324\u20131329. https:\/\/doi.org\/10.1126\/science.aaf1064","journal-title":"Science"}],"container-title":["Cellular and Molecular Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-019-03078-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00018-019-03078-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-019-03078-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T02:13:28Z","timestamp":1663208008000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00018-019-03078-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,3]]},"references-count":120,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["3078"],"URL":"https:\/\/doi.org\/10.1007\/s00018-019-03078-5","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/504225","asserted-by":"object"}]},"ISSN":["1420-682X","1420-9071"],"issn-type":[{"value":"1420-682X","type":"print"},{"value":"1420-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,3]]},"assertion":[{"value":"20 December 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 February 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 March 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 April 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The author(s) declared no potential conflicts of interest with respect to the research, authorship, and\/or publication of this article. All authors consent for the publication of this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The datasets supporting the conclusions of this article are available in the Sequence Reads Archives (SRA;\n                      \n                      ) of the National Center for Biotechnology Information (NCBI) with the accession number: SRP139153. Datasets of a total of ~\u200917.4 billion bases of unprocessed RNA sequencing were deposited as FASTq files at the SRA. The project overview was deposited with the Bioproject accession number: PRJNA449172. The optic nerves of <i>SLICK<\/i>-<i>H::Ranbp2<\/i><sup>+<i>\/<\/i>+<\/sup>, <i>SLICK<\/i>-<i>H::Ranbp2<\/i><sup><i>flox\/flox<\/i><\/sup> and <i>Tg<\/i>-<i>RBD<\/i><sup><i>2\/3*<\/i>-<i>HA<\/i><\/sup><i>::SLICK<\/i>-<i>H::Ranbp2<\/i><sup><i>flox\/flox<\/i><\/sup> have the respective biosamples accession numbers: SAMN08891694, SAMN08891693 and SAMN08891695. Other datasets and materials used and\/or analyzed during the current study are available from the corresponding author on reasonable request.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of data and materials"}}]}}