{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:18:56Z","timestamp":1772119136405,"version":"3.50.1"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"18","license":[{"start":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T00:00:00Z","timestamp":1575331200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T00:00:00Z","timestamp":1575331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100009053","name":"The Wellcome Trust DBT India Alliance","doi-asserted-by":"publisher","award":["IA\/I\/13\/2\/501030"],"award-info":[{"award-number":["IA\/I\/13\/2\/501030"]}],"id":[{"id":"10.13039\/501100009053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology","doi-asserted-by":"publisher","award":["BT\/RLF\/Re-entry\/54\/2013"],"award-info":[{"award-number":["BT\/RLF\/Re-entry\/54\/2013"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology","doi-asserted-by":"publisher","award":["BT\/09\/IYBA\/2015\/03"],"award-info":[{"award-number":["BT\/09\/IYBA\/2015\/03"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell. Mol. Life Sci."],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1007\/s00018-019-03392-y","type":"journal-article","created":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T14:03:12Z","timestamp":1575381792000},"page":"3657-3670","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["A role of cellular translation regulation associated with toxic Huntingtin protein"],"prefix":"10.1007","volume":"77","author":[{"given":"Hiranmay","family":"Joag","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vighnesh","family":"Ghatpande","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meghal","family":"Desai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maitheli","family":"Sarkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anshu","family":"Raina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mrunalini","family":"Shinde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruta","family":"Chitale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ankita","family":"Deo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tania","family":"Bose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6594-0672","authenticated-orcid":false,"given":"Amitabha","family":"Majumdar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,12,3]]},"reference":[{"key":"3392_CR1","doi-asserted-by":"publisher","first-page":"15005","DOI":"10.1038\/nrdp.2015.5","volume":"1","author":"GP Bates","year":"2015","unstructured":"Bates GP, Dorsey R, Gusella JF et al (2015) Huntington disease. Nat Rev Dis Primers 1:15005. https:\/\/doi.org\/10.1038\/nrdp.2015.5","journal-title":"Nat Rev Dis Primers"},{"key":"3392_CR2","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1146\/annurev.neuro.29.051605.113042","volume":"30","author":"HT Orr","year":"2007","unstructured":"Orr HT, Zoghbi HY (2007) Trinucleotide repeat disorders. Annu Rev Neurosci 30:575\u2013621. https:\/\/doi.org\/10.1146\/annurev.neuro.29.051605.113042","journal-title":"Annu Rev Neurosci"},{"key":"3392_CR3","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","volume":"72","author":"ME MacDonald","year":"1993","unstructured":"MacDonald ME, Ambrose CM, Duyao MP et al (1993) A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington\u2019s disease chromosomes. Cell 72:971\u2013983. https:\/\/doi.org\/10.1016\/0092-8674(93)90585-E","journal-title":"Cell"},{"key":"3392_CR4","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1212\/WNL.0b013e318249f683","volume":"78","author":"J-M Lee","year":"2012","unstructured":"Lee J-M, Ramos EM, Lee J-H et al (2012) CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion. Neurology 78:690\u2013695. https:\/\/doi.org\/10.1212\/WNL.0b013e318249f683","journal-title":"Neurology"},{"key":"3392_CR5","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1083\/jcb.201709072","volume":"217","author":"CL Klaips","year":"2018","unstructured":"Klaips CL, Jayaraj GG, Hartl FU (2018) Pathways of cellular proteostasis in aging and disease. J Cell Biol 217:51\u201363. https:\/\/doi.org\/10.1083\/jcb.201709072","journal-title":"J Cell Biol"},{"key":"3392_CR6","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1038\/nature06022","volume":"448","author":"EJ Bennett","year":"2007","unstructured":"Bennett EJ, Shaler TA, Woodman B et al (2007) Global changes to the ubiquitin system in Huntington\u2019s disease. Nature 448:704\u2013708. https:\/\/doi.org\/10.1038\/nature06022","journal-title":"Nature"},{"key":"3392_CR7","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.molcel.2010.01.001","volume":"37","author":"J Hageman","year":"2010","unstructured":"Hageman J, Rujano MA, van Waarde MAWH et al (2010) A DNAJB chaperone subfamily with HDAC-dependent activities suppresses toxic protein aggregation. Mol Cell 37:355\u2013369. https:\/\/doi.org\/10.1016\/j.molcel.2010.01.001","journal-title":"Mol Cell"},{"key":"3392_CR8","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1093\/hmg\/ddh144","volume":"13","author":"DG Hay","year":"2004","unstructured":"Hay DG, Sathasivam K, Tobaben S et al (2004) Progressive decrease in chaperone protein levels in a mouse model of Huntington\u2019s disease and induction of stress proteins as a therapeutic approach. Hum Mol Genet 13:1389\u20131405. https:\/\/doi.org\/10.1093\/hmg\/ddh144","journal-title":"Hum Mol Genet"},{"key":"3392_CR9","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1083\/jcb.201110093","volume":"196","author":"MS Hipp","year":"2012","unstructured":"Hipp MS, Patel CN, Bersuker K et al (2012) Indirect inhibition of 26S proteasome activity in a cellular model of Huntington\u2019s disease. J Cell Biol 196:573\u2013587. https:\/\/doi.org\/10.1083\/jcb.201110093","journal-title":"J Cell Biol"},{"key":"3392_CR10","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1093\/brain\/aws022","volume":"135","author":"J Labbadia","year":"2012","unstructured":"Labbadia J, Novoselov SS, Bett JS et al (2012) Suppression of protein aggregation by chaperone modification of high molecular weight complexes. Brain 135:1180\u20131196. https:\/\/doi.org\/10.1093\/brain\/aws022","journal-title":"Brain"},{"key":"3392_CR11","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1038\/nn.2528","volume":"13","author":"M Martinez-Vicente","year":"2010","unstructured":"Martinez-Vicente M, Talloczy Z, Wong E et al (2010) Cargo recognition failure is responsible for inefficient autophagy in Huntington\u2019s disease. Nat Neurosci 13:567\u2013576. https:\/\/doi.org\/10.1038\/nn.2528","journal-title":"Nat Neurosci"},{"key":"3392_CR12","doi-asserted-by":"publisher","first-page":"5829","DOI":"10.1007\/s12035-016-0120-z","volume":"54","author":"SD Reis","year":"2017","unstructured":"Reis SD, Pinho BR, Oliveira JMA (2017) Modulation of molecular chaperones in Huntington\u2019s disease and other polyglutamine disorders. Mol Neurobiol 54:5829\u20135854. https:\/\/doi.org\/10.1007\/s12035-016-0120-z","journal-title":"Mol Neurobiol"},{"key":"3392_CR13","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1074\/jbc.M110.101527","volume":"286","author":"E Tauber","year":"2011","unstructured":"Tauber E, Miller-Fleming L, Mason RP et al (2011) Functional gene expression profiling in yeast implicates translational dysfunction in mutant huntingtin toxicity. J Biol Chem 286:410\u2013419. https:\/\/doi.org\/10.1074\/jbc.M110.101527","journal-title":"J Biol Chem"},{"key":"3392_CR14","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.11792","author":"J Yang","year":"2016","unstructured":"Yang J, Hao X, Cao X et al (2016) Spatial sequestration and detoxification of Huntingtin by the ribosome quality control complex. Elife. https:\/\/doi.org\/10.7554\/eLife.11792","journal-title":"Elife"},{"key":"3392_CR15","doi-asserted-by":"publisher","first-page":"21599","DOI":"10.1074\/jbc.M112.359307","volume":"287","author":"BP Culver","year":"2012","unstructured":"Culver BP, Savas JN, Park SK et al (2012) Proteomic analysis of wild-type and mutant huntingtin-associated proteins in mouse brains identifies unique interactions and involvement in protein synthesis. J Biol Chem 287:21599\u201321614. https:\/\/doi.org\/10.1074\/jbc.M112.359307","journal-title":"J Biol Chem"},{"key":"3392_CR16","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1016\/j.molcel.2016.07.022","volume":"63","author":"YE Kim","year":"2016","unstructured":"Kim YE, Hosp F, Frottin F et al (2016) Soluble Oligomers of PolyQ-expanded huntingtin target a multiplicity of key cellular factors. Mol Cell 63:951\u2013964. https:\/\/doi.org\/10.1016\/j.molcel.2016.07.022","journal-title":"Mol Cell"},{"key":"3392_CR17","doi-asserted-by":"publisher","first-page":"2291","DOI":"10.1016\/j.celrep.2017.10.097","volume":"21","author":"F Hosp","year":"2017","unstructured":"Hosp F, Guti\u00e9rrez-\u00c1ngel S, Schaefer MH et al (2017) Spatiotemporal proteomic profiling of Huntington\u2019s disease inclusions reveals widespread loss of protein function. Cell Rep 21:2291\u20132303. https:\/\/doi.org\/10.1016\/j.celrep.2017.10.097","journal-title":"Cell Rep"},{"key":"3392_CR18","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1016\/j.neuron.2015.10.038","volume":"88","author":"M Ba\u00f1ez-Coronel","year":"2015","unstructured":"Ba\u00f1ez-Coronel M, Ayhan F, Tarabochia AD et al (2015) RAN translation in huntington disease. Neuron 88:667\u2013677. https:\/\/doi.org\/10.1016\/j.neuron.2015.10.038","journal-title":"Neuron"},{"key":"3392_CR19","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1016\/j.cell.2006.04.026","volume":"125","author":"RK Graham","year":"2006","unstructured":"Graham RK, Deng Y, Slow EJ et al (2006) Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin. Cell 125:1179\u20131191. https:\/\/doi.org\/10.1016\/j.cell.2006.04.026","journal-title":"Cell"},{"key":"3392_CR20","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1073\/pnas.49.1.122","volume":"49","author":"JR Warner","year":"1963","unstructured":"Warner JR, Knopf PM, Rich A (1963) A multiple ribosomal structure in protein synthesis. Proc Natl Acad Sci USA 49:122\u2013129. https:\/\/doi.org\/10.1073\/pnas.49.1.122","journal-title":"Proc Natl Acad Sci USA"},{"key":"3392_CR21","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1083\/jcb.200112104","volume":"157","author":"AB Meriin","year":"2002","unstructured":"Meriin AB, Zhang X, He X et al (2002) Huntingtin toxicity in yeast model depends on polyglutamine aggregation mediated by a prion-like protein Rnq1. J Cell Biol 157:997\u20131004. https:\/\/doi.org\/10.1083\/jcb.200112104","journal-title":"J Cell Biol"},{"key":"3392_CR22","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1073\/pnas.51.4.585","volume":"51","author":"D Nathans","year":"1964","unstructured":"Nathans D (1964) Puromycin inhibition of protein synthesis: incorporation of puromycin into peptide chains. PNAS 51:585\u2013592. https:\/\/doi.org\/10.1073\/pnas.51.4.585","journal-title":"PNAS"},{"key":"3392_CR23","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1242\/bio.026294","volume":"6","author":"LP Deliu","year":"2017","unstructured":"Deliu LP, Ghosh A, Grewal SS (2017) Investigation of protein synthesis in Drosophila larvae using puromycin labelling. Biol Open 6:1229\u20131234. https:\/\/doi.org\/10.1242\/bio.026294","journal-title":"Biol Open"},{"key":"3392_CR24","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/nmeth.1314","volume":"6","author":"EK Schmidt","year":"2009","unstructured":"Schmidt EK, Clavarino G, Ceppi M, Pierre P (2009) SUnSET, a nonradioactive method to monitor protein synthesis. Nat Methods 6:275\u2013277. https:\/\/doi.org\/10.1038\/nmeth.1314","journal-title":"Nat Methods"},{"key":"3392_CR25","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1073\/pnas.1111561108","volume":"109","author":"J Liu","year":"2012","unstructured":"Liu J, Xu Y, Stoleru D, Salic A (2012) Imaging protein synthesis in cells and tissues with an alkyne analog of puromycin. Proc Natl Acad Sci USA 109:413\u2013418. https:\/\/doi.org\/10.1073\/pnas.1111561108","journal-title":"Proc Natl Acad Sci USA"},{"key":"3392_CR26","doi-asserted-by":"publisher","first-page":"39","DOI":"10.3233\/JHD-150177","volume":"5","author":"BP Culver","year":"2016","unstructured":"Culver BP, DeClercq J, Dolgalev I et al (2016) Huntington\u2019s disease protein Huntingtin associates with its own mRNA. J Huntingtons Dis 5:39\u201351. https:\/\/doi.org\/10.3233\/JHD-150177","journal-title":"J Huntingtons Dis"},{"key":"3392_CR27","doi-asserted-by":"publisher","first-page":"e1002361","DOI":"10.1371\/journal.pbio.1002361","volume":"14","author":"R Herv\u00e1s","year":"2016","unstructured":"Herv\u00e1s R, Li L, Majumdar A et al (2016) Molecular Basis of Orb2 amyloidogenesis and blockade of memory consolidation. PLoS Biol 14:e1002361. https:\/\/doi.org\/10.1371\/journal.pbio.1002361","journal-title":"PLoS Biol"},{"key":"3392_CR28","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1146\/annurev-cellbio-101011-155831","volume":"30","author":"M Ivshina","year":"2014","unstructured":"Ivshina M, Lasko P, Richter JD (2014) Cytoplasmic polyadenylation element binding proteins in development, health, and disease. Annu Rev Cell Dev Biol 30:393\u2013415. https:\/\/doi.org\/10.1146\/annurev-cellbio-101011-155831","journal-title":"Annu Rev Cell Dev Biol"},{"key":"3392_CR29","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1038\/nn1996","volume":"10","author":"K Keleman","year":"2007","unstructured":"Keleman K, Kr\u00fcttner S, Alenius M, Dickson BJ (2007) Function of the Drosophila CPEB protein Orb2 in long-term courtship memory. Nat Neurosci 10:1587\u20131593. https:\/\/doi.org\/10.1038\/nn1996","journal-title":"Nat Neurosci"},{"key":"3392_CR30","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/j.cell.2012.01.004","volume":"148","author":"A Majumdar","year":"2012","unstructured":"Majumdar A, Cesario WC, White-Grindley E et al (2012) Critical role of amyloid-like oligomers of Drosophila Orb2 in the persistence of memory. Cell 148:515\u2013529. https:\/\/doi.org\/10.1016\/j.cell.2012.01.004","journal-title":"Cell"},{"key":"3392_CR31","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.1016\/j.cell.2015.11.020","volume":"163","author":"MR Khan","year":"2015","unstructured":"Khan MR, Li L, P\u00e9rez-S\u00e1nchez C et al (2015) Amyloidogenic oligomerization transforms Drosophila Orb2 from a translation repressor to an activator. Cell 163:1468\u20131483. https:\/\/doi.org\/10.1016\/j.cell.2015.11.020","journal-title":"Cell"},{"key":"3392_CR32","unstructured":"Screening for Amyloid Aggregation by Semi-Denaturing Detergent-Agarose Gel Electrophoresis| Protocol. https:\/\/www.jove.com\/video\/838\/screening-for-amyloid-aggregation-semi-denaturing-detergent-agarose. Accessed 28 Oct 2019"},{"key":"3392_CR33","doi-asserted-by":"publisher","first-page":"9171","DOI":"10.1523\/JNEUROSCI.3040-05.2005","volume":"25","author":"Q Ding","year":"2005","unstructured":"Ding Q, Markesbery WR, Chen Q et al (2005) Ribosome dysfunction is an early event in Alzheimer\u2019s disease. J Neurosci 25:9171\u20139175. https:\/\/doi.org\/10.1523\/JNEUROSCI.3040-05.2005","journal-title":"J Neurosci"},{"key":"3392_CR34","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1093\/hmg\/ddx035","volume":"26","author":"A Russo","year":"2017","unstructured":"Russo A, Scardigli R, La Regina F et al (2017) Increased cytoplasmic TDP-43 reduces global protein synthesis by interacting with RACK1 on polyribosomes. Hum Mol Genet 26:1407\u20131418. https:\/\/doi.org\/10.1093\/hmg\/ddx035","journal-title":"Hum Mol Genet"},{"key":"3392_CR35","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1016\/j.neuron.2018.09.044","volume":"100","author":"J L\u00f3pez-Erauskin","year":"2018","unstructured":"L\u00f3pez-Erauskin J, Tadokoro T, Baughn MW et al (2018) ALS\/FTD-linked mutation in FUS suppresses intra-axonal protein synthesis and drives disease without nuclear loss-of-function of FUS. Neuron 100:816\u2013830.e7. https:\/\/doi.org\/10.1016\/j.neuron.2018.09.044","journal-title":"Neuron"},{"key":"3392_CR36","doi-asserted-by":"publisher","first-page":"E11904","DOI":"10.1073\/pnas.1810413115","volume":"115","author":"M Kamelgarn","year":"2018","unstructured":"Kamelgarn M, Chen J, Kuang L et al (2018) ALS mutations of FUS suppress protein translation and disrupt the regulation of nonsense-mediated decay. Proc Natl Acad Sci USA 115:E11904\u2013E11913. https:\/\/doi.org\/10.1073\/pnas.1810413115","journal-title":"Proc Natl Acad Sci USA"},{"key":"3392_CR37","doi-asserted-by":"crossref","unstructured":"Hartmann H, Hornburg D, Czuppa M, et al (2018) Proteomics and C9orf72 neuropathology identify ribosomes as poly-GR\/PR interactors driving toxicity. Life Sci Alliance. https:\/\/doi.org\/10.26508\/lsa.201800070","DOI":"10.26508\/lsa.201800070"},{"key":"3392_CR38","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1038\/s41591-018-0071-1","volume":"24","author":"Y-J Zhang","year":"2018","unstructured":"Zhang Y-J, Gendron TF, Ebbert MTW et al (2018) Poly(GR) impairs protein translation and stress granule dynamics in C9orf72 -associated frontotemporal dementia and amyotrophic lateral sclerosis. Nat Med 24:1136. https:\/\/doi.org\/10.1038\/s41591-018-0071-1","journal-title":"Nat Med"},{"key":"3392_CR39","doi-asserted-by":"publisher","first-page":"1803","DOI":"10.1093\/hmg\/ddw052","volume":"25","author":"K Kanekura","year":"2016","unstructured":"Kanekura K, Yagi T, Cammack AJ et al (2016) Poly-dipeptides encoded by the C9ORF72 repeats block global protein translation. Hum Mol Genet 25:1803\u20131813. https:\/\/doi.org\/10.1093\/hmg\/ddw052","journal-title":"Hum Mol Genet"},{"key":"3392_CR40","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1007\/s00401-018-1946-4","volume":"137","author":"TG Moens","year":"2019","unstructured":"Moens TG, Niccoli T, Wilson KM et al (2019) C9orf72 arginine-rich dipeptide proteins interact with ribosomal proteins in vivo to induce a toxic translational arrest that is rescued by eIF1A. Acta Neuropathol 137:487\u2013500. https:\/\/doi.org\/10.1007\/s00401-018-1946-4","journal-title":"Acta Neuropathol"},{"key":"3392_CR41","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1523\/JNEUROSCI.3029-15.2016","volume":"36","author":"S Meier","year":"2016","unstructured":"Meier S, Bell M, Lyons DN et al (2016) Pathological tau promotes neuronal damage by impairing ribosomal function and decreasing protein synthesis. J Neurosci 36:1001\u20131007. https:\/\/doi.org\/10.1523\/JNEUROSCI.3029-15.2016","journal-title":"J Neurosci"},{"key":"3392_CR42","doi-asserted-by":"publisher","unstructured":"Eshraghi M, Karunadharma P, Blin J et al (2019) Global ribosome profiling reveals that mutant huntingtin stalls ribosomes and represses protein synthesis independent of fragile X mental retardation protein. https:\/\/doi.org\/10.1101\/629667","DOI":"10.1101\/629667"},{"key":"3392_CR43","doi-asserted-by":"publisher","first-page":"5153","DOI":"10.1523\/JNEUROSCI.0783-09.2009","volume":"29","author":"Y Furukawa","year":"2009","unstructured":"Furukawa Y, Kaneko K, Matsumoto G et al (2009) Cross-seeding fibrillation of Q\/N-rich proteins offers new pathomechanism of polyglutamine diseases. J Neurosci 29:5153\u20135162. https:\/\/doi.org\/10.1523\/JNEUROSCI.0783-09.2009","journal-title":"J Neurosci"},{"key":"3392_CR44","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1126\/science.1082324","volume":"300","author":"BI Giasson","year":"2003","unstructured":"Giasson BI, Forman MS, Higuchi M et al (2003) Initiation and synergistic fibrillization of tau and alpha-synuclein. Science 300:636\u2013640. https:\/\/doi.org\/10.1126\/science.1082324","journal-title":"Science"},{"key":"3392_CR45","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.cell.2013.05.057","volume":"154","author":"JL Guo","year":"2013","unstructured":"Guo JL, Covell DJ, Daniels JP et al (2013) Distinct \u03b1-synuclein strains differentially promote tau inclusions in neurons. Cell 154:103\u2013117. https:\/\/doi.org\/10.1016\/j.cell.2013.05.057","journal-title":"Cell"},{"key":"3392_CR46","doi-asserted-by":"publisher","first-page":"e1006563","DOI":"10.1371\/journal.ppat.1006563","volume":"13","author":"E Katorcha","year":"2017","unstructured":"Katorcha E, Makarava N, Lee YJ et al (2017) Cross-seeding of prions by aggregated \u03b1-synuclein leads to transmissible spongiform encephalopathy. PLoS Pathog 13:e1006563. https:\/\/doi.org\/10.1371\/journal.ppat.1006563","journal-title":"PLoS Pathog"},{"key":"3392_CR47","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1111\/j.1471-4159.2012.07847.x","volume":"122","author":"K Ono","year":"2012","unstructured":"Ono K, Takahashi R, Ikeda T, Yamada M (2012) Cross-seeding effects of amyloid \u03b2-protein and \u03b1-synuclein. J Neurochem 122:883\u2013890. https:\/\/doi.org\/10.1111\/j.1471-4159.2012.07847.x","journal-title":"J Neurochem"},{"key":"3392_CR48","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1172\/JCI85594","volume":"127","author":"M Tanaka","year":"2017","unstructured":"Tanaka M, Ishizuka K, Nekooki-Machida Y et al (2017) Aggregation of scaffolding protein DISC1 dysregulates phosphodiesterase 4 in Huntington\u2019s disease. J Clin Invest 127:1438\u20131450. https:\/\/doi.org\/10.1172\/JCI85594","journal-title":"J Clin Invest"},{"key":"3392_CR49","doi-asserted-by":"publisher","first-page":"e177","DOI":"10.1371\/journal.pgen.0030177","volume":"3","author":"J Bilen","year":"2007","unstructured":"Bilen J, Bonini NM (2007) Genome-wide screen for modifiers of Ataxin-3 neurodegeneration in Drosophila. PLoS Genet 3:e177. https:\/\/doi.org\/10.1371\/journal.pgen.0030177","journal-title":"PLoS Genet"},{"key":"3392_CR50","doi-asserted-by":"publisher","unstructured":"Burguete AS, Almeida S, Gao F-B et al (2015) GGGGCC microsatellite RNA is neuritically localized, induces branching defects, and perturbs transport granule function. eLife 4:e08881. https:\/\/doi.org\/10.7554\/eLife.08881","DOI":"10.7554\/eLife.08881"},{"key":"3392_CR51","doi-asserted-by":"publisher","first-page":"18219","DOI":"10.1073\/pnas.1421313111","volume":"111","author":"L Ripaud","year":"2014","unstructured":"Ripaud L, Chumakova V, Antonin M et al (2014) Overexpression of Q-rich prion-like proteins suppresses polyQ cytotoxicity and alters the polyQ interactome. Proc Natl Acad Sci USA 111:18219\u201318224. https:\/\/doi.org\/10.1073\/pnas.1421313111","journal-title":"Proc Natl Acad Sci USA"},{"key":"3392_CR52","doi-asserted-by":"publisher","first-page":"12085","DOI":"10.1073\/pnas.1412504111","volume":"111","author":"C Kayatekin","year":"2014","unstructured":"Kayatekin C, Matlack KES, Hesse WR et al (2014) Prion-like proteins sequester and suppress the toxicity of huntingtin exon 1. Proc Natl Acad Sci USA 111:12085\u201312090. https:\/\/doi.org\/10.1073\/pnas.1412504111","journal-title":"Proc Natl Acad Sci USA"},{"key":"3392_CR53","doi-asserted-by":"publisher","first-page":"E7030","DOI":"10.1073\/pnas.1603715113","volume":"113","author":"BK Stepien","year":"2016","unstructured":"Stepien BK, Oppitz C, Gerlach D et al (2016) RNA-binding profiles of Drosophila CPEB proteins Orb and Orb2. PNAS 113:E7030\u2013E7038. https:\/\/doi.org\/10.1073\/pnas.1603715113","journal-title":"PNAS"},{"key":"3392_CR54","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.nbd.2006.06.015","volume":"24","author":"Z Fayazi","year":"2006","unstructured":"Fayazi Z, Ghosh S, Marion S et al (2006) A Drosophila ortholog of the human MRJ modulates polyglutamine toxicity and aggregation. Neurobiol Dis 24:226\u2013244. https:\/\/doi.org\/10.1016\/j.nbd.2006.06.015","journal-title":"Neurobiol Dis"},{"key":"3392_CR55","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.1126\/science.287.5459.1837","volume":"287","author":"P Kazemi-Esfarjani","year":"2000","unstructured":"Kazemi-Esfarjani P, Benzer S (2000) Genetic suppression of polyglutamine toxicity in Drosophila. Science 287:1837\u20131840. https:\/\/doi.org\/10.1126\/science.287.5459.1837","journal-title":"Science"},{"key":"3392_CR56","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1042\/BST0360665","volume":"36","author":"E Belloc","year":"2008","unstructured":"Belloc E, Piqu\u00e9 M, M\u00e9ndez R (2008) Sequential waves of polyadenylation and deadenylation define a translation circuit that drives meiotic progression. Biochem Soc Trans 36:665\u2013670. https:\/\/doi.org\/10.1042\/BST0360665","journal-title":"Biochem Soc Trans"},{"key":"3392_CR57","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/j.cell.2007.12.038","volume":"132","author":"M Piqu\u00e9","year":"2008","unstructured":"Piqu\u00e9 M, L\u00f3pez JM, Foissac S et al (2008) A combinatorial code for CPE-mediated translational control. Cell 132:434\u2013448. https:\/\/doi.org\/10.1016\/j.cell.2007.12.038","journal-title":"Cell"},{"key":"3392_CR58","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1038\/s41586-018-0423-5","volume":"560","author":"A Parras","year":"2018","unstructured":"Parras A, Anta H, Santos-Galindo M et al (2018) Autism-like phenotype and risk gene mRNA deadenylation by CPEB4 mis-splicing. Nature 560:441\u2013446. https:\/\/doi.org\/10.1038\/s41586-018-0423-5","journal-title":"Nature"},{"key":"3392_CR59","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1007\/s00415-019-09263-7","volume":"266","author":"T Aldaz","year":"2019","unstructured":"Aldaz T, Nigro P, S\u00e1nchez-G\u00f3mez A et al (2019) Non-motor symptoms in Huntington\u2019s disease: a comparative study with Parkinson\u2019s disease. J Neurol 266:1340\u20131350. https:\/\/doi.org\/10.1007\/s00415-019-09263-7","journal-title":"J Neurol"},{"key":"3392_CR60","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.neuropsychologia.2019.02.017","volume":"127","author":"AM Carmichael","year":"2019","unstructured":"Carmichael AM, Irish M, Glikmann-Johnston Y et al (2019) Pervasive autobiographical memory impairments in Huntington\u2019s disease. Neuropsychologia 127:123\u2013130. https:\/\/doi.org\/10.1016\/j.neuropsychologia.2019.02.017","journal-title":"Neuropsychologia"},{"key":"3392_CR61","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1534\/genetics.111.133710","volume":"190","author":"KR Weiss","year":"2012","unstructured":"Weiss KR, Kimura Y, Lee W-CM, Littleton JT (2012) Huntingtin aggregation kinetics and their pathological role in a Drosophila Huntington\u2019s disease model. Genetics 190:581\u2013600. https:\/\/doi.org\/10.1534\/genetics.111.133710","journal-title":"Genetics"},{"key":"3392_CR62","doi-asserted-by":"publisher","first-page":"W467","DOI":"10.1093\/nar\/gky508","volume":"46","author":"G Koulouras","year":"2018","unstructured":"Koulouras G, Panagopoulos A, Rapsomaniki MA et al (2018) EasyFRAP-web: a web-based tool for the analysis of fluorescence recovery after photobleaching data. Nucl Acids Res 46:W467\u2013W472. https:\/\/doi.org\/10.1093\/nar\/gky508","journal-title":"Nucl Acids Res"},{"key":"3392_CR63","doi-asserted-by":"publisher","first-page":"1800","DOI":"10.1093\/bioinformatics\/bts241","volume":"28","author":"MA Rapsomaniki","year":"2012","unstructured":"Rapsomaniki MA, Kotsantis P, Symeonidou I-E et al (2012) easyFRAP: an interactive, easy-to-use tool for qualitative and quantitative analysis of FRAP data. Bioinformatics 28:1800\u20131801. https:\/\/doi.org\/10.1093\/bioinformatics\/bts241","journal-title":"Bioinformatics"}],"container-title":["Cellular and Molecular Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-019-03392-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00018-019-03392-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-019-03392-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T20:09:15Z","timestamp":1606853355000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00018-019-03392-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,3]]},"references-count":63,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["3392"],"URL":"https:\/\/doi.org\/10.1007\/s00018-019-03392-y","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/687764","asserted-by":"object"}]},"ISSN":["1420-682X","1420-9071"],"issn-type":[{"value":"1420-682X","type":"print"},{"value":"1420-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,3]]},"assertion":[{"value":"7 July 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 November 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 November 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 December 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}