{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T22:03:21Z","timestamp":1786917801846,"version":"build-2736575974"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"19","license":[{"start":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T00:00:00Z","timestamp":1575849600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T00:00:00Z","timestamp":1575849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100009553","name":"Agentura Pro Zdravotnick\u00fd V\u00fdzkum \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["15-34405A"],"award-info":[{"award-number":["15-34405A"]}],"id":[{"id":"10.13039\/501100009553","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Regional Development Fund OP RDE","award":["CZ.02.1.01\/0.0\/0.0\/16_019\/0000729"],"award-info":[{"award-number":["CZ.02.1.01\/0.0\/0.0\/16_019\/0000729"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell. Mol. Life Sci."],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1007\/s00018-019-03397-7","type":"journal-article","created":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T13:02:58Z","timestamp":1575896578000},"page":"3885-3903","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Elucidation of protein interactions necessary for the maintenance of the BCR\u2013ABL signaling complex"],"prefix":"10.1007","volume":"77","author":[{"given":"Tomas","family":"Gregor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela Kunova","family":"Bosakova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandru","family":"Nita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara P.","family":"Abraham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bohumil","family":"Fafilek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole H.","family":"Cernohorsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Rynes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvie","family":"Foldynova-Trantirkova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Zackova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiri","family":"Mayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Trantirek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0618-9134","authenticated-orcid":false,"given":"Pavel","family":"Krejci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,12,9]]},"reference":[{"key":"3397_CR1","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/nsb747","volume":"9","author":"X Zhao","year":"2002","unstructured":"Zhao X, Ghaffari S, Lodish H et al (2002) Structure of the BCR\u2013ABL oncoprotein oligomerization domain. Nat Struct Biol 9:117\u2013120. https:\/\/doi.org\/10.1038\/nsb747","journal-title":"Nat Struct Biol"},{"key":"3397_CR2","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1177\/1947601912458584","volume":"3","author":"O Hantschel","year":"2012","unstructured":"Hantschel O (2012) Structure, regulation, signaling, and targeting of Abl kinases in cancer. Genes Cancer 3:436\u2013446. https:\/\/doi.org\/10.1177\/1947601912458584","journal-title":"Genes Cancer"},{"key":"3397_CR3","doi-asserted-by":"publisher","first-page":"4603","DOI":"10.1182\/blood.V86.12.4603.bloodjournal86124603","volume":"86","author":"JW Voncken","year":"1995","unstructured":"Voncken JW, Kaartinen V, Pattengale PK et al (1995) BCR\/ABL P210 and P190 cause distinct leukemia in transgenic mice. Blood 86:4603\u20134611","journal-title":"Blood"},{"key":"3397_CR4","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1177\/107327480901600202","volume":"16","author":"LA Hazlehurst","year":"2009","unstructured":"Hazlehurst LA, Bewry NN, Nair RR, Pinilla-Ibarz J (2009) Signaling networks associated with BCR\u2013ABL-dependent transformation. Cancer Control J Moffitt Cancer Cent 16:100\u2013107. https:\/\/doi.org\/10.1177\/107327480901600202","journal-title":"Cancer Control J Moffitt Cancer Cent"},{"key":"3397_CR5","doi-asserted-by":"publisher","first-page":"6151","DOI":"10.1093\/emboj\/16.20.6151","volume":"16","author":"T Skorski","year":"1997","unstructured":"Skorski T, Bellacosa A, Nieborowska-Skorska M et al (1997) Transformation of hematopoietic cells by BCR\/ABL requires activation of a PI-3\u00a0k\/Akt-dependent pathway. EMBO J 16:6151\u20136161","journal-title":"EMBO J"},{"key":"3397_CR6","first-page":"247","volume":"13","author":"K Shuai","year":"1996","unstructured":"Shuai K, Halpern J, ten Hoeve J et al (1996) Constitutive activation of STAT5 by the BCR\u2013ABL oncogene in chronic myelogenous leukemia. Oncogene 13:247\u2013254","journal-title":"Oncogene"},{"key":"3397_CR7","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1038\/sj.leu.2403241","volume":"18","author":"LS Steelman","year":"2004","unstructured":"Steelman LS, Pohnert SC, Shelton JG et al (2004) JAK\/STAT, Raf\/MEK\/ERK, PI3K\/Akt and BCR\u2013ABL in cell cycle progression and leukemogenesis. Leukemia 18:189\u2013218. https:\/\/doi.org\/10.1038\/sj.leu.2403241","journal-title":"Leukemia"},{"key":"3397_CR8","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1038\/nm0596-561","volume":"2","author":"BJ Druker","year":"1996","unstructured":"Druker BJ, Tamura S, Buchdunger E et al (1996) Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of BCR\u2013ABL positive cells. Nat Med 2:561\u2013566","journal-title":"Nat Med"},{"key":"3397_CR9","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1126\/science.1062538","volume":"293","author":"ME Gorre","year":"2001","unstructured":"Gorre ME, Mohammed M, Ellwood K et al (2001) Clinical resistance to STI-571 cancer therapy caused by BCR\u2013ABL gene mutation or amplification. Science 293:876\u2013880. https:\/\/doi.org\/10.1126\/science.1062538","journal-title":"Science"},{"key":"3397_CR10","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.ddtec.2013.12.001","volume":"11","author":"M Modugno","year":"2014","unstructured":"Modugno M (2014) New resistance mechanisms for small molecule kinase inhibitors of Abl kinase. Drug Discov Today Technol 11:5\u201310. https:\/\/doi.org\/10.1016\/j.ddtec.2013.12.001","journal-title":"Drug Discov Today Technol"},{"key":"3397_CR11","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.ccr.2005.01.007","volume":"7","author":"E Weisberg","year":"2005","unstructured":"Weisberg E, Manley PW, Breitenstein W et al (2005) Characterization of AMN107, a selective inhibitor of native and mutant BCR\u2013ABL. Cancer Cell 7:129\u2013141. https:\/\/doi.org\/10.1016\/j.ccr.2005.01.007","journal-title":"Cancer Cell"},{"key":"3397_CR12","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1182\/blood.V106.11.1093.1093","volume":"106","author":"NP Shah","year":"2005","unstructured":"Shah NP, Nicoll JM, Branford S et al (2005) Molecular analysis of dasatinib resistance mechanisms in CML patients identifies novel BCR\u2013ABL mutations predicted to retain sensitivity to imatinib: rationale for combination tyrosine kinase inhibitor therapy. Blood 106:1093","journal-title":"Blood"},{"key":"3397_CR13","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1038\/leu.2008.84","volume":"22","author":"A Hochhaus","year":"2008","unstructured":"Hochhaus A, Baccarani M, Deininger M et al (2008) Dasatinib induces durable cytogenetic responses in patients with chronic myelogenous leukemia in chronic phase with resistance or intolerance to imatinib. Leukemia 22:1200\u20131206. https:\/\/doi.org\/10.1038\/leu.2008.84","journal-title":"Leukemia"},{"key":"3397_CR14","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1111\/j.1747-0285.2007.00556.x","volume":"70","author":"T Zhou","year":"2007","unstructured":"Zhou T, Parillon L, Li F et al (2007) Crystal structure of the T315I mutant of Abl kinase. Chem Biol Drug Des 70:171\u2013181. https:\/\/doi.org\/10.1111\/j.1747-0285.2007.00556.x","journal-title":"Chem Biol Drug Des"},{"key":"3397_CR15","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.1056\/NEJMoa1306494","volume":"369","author":"JE Cortes","year":"2013","unstructured":"Cortes JE, Kim D-W, Pinilla-Ibarz J et al (2013) A phase 2 trial of ponatinib in Philadelphia chromosome-positive leukemias. N Engl J Med 369:1783\u20131796. https:\/\/doi.org\/10.1056\/NEJMoa1306494","journal-title":"N Engl J Med"},{"key":"3397_CR16","doi-asserted-by":"publisher","first-page":"3169","DOI":"10.1158\/1535-7163.MCT-08-0314","volume":"7","author":"NN Bewry","year":"2008","unstructured":"Bewry NN, Nair RR, Emmons MF et al (2008) Stat3 contributes to resistance toward BCR\u2013ABL inhibitors in a bone marrow microenvironment model of drug resistance. Mol Cancer Ther 7:3169\u20133175. https:\/\/doi.org\/10.1158\/1535-7163.MCT-08-0314","journal-title":"Mol Cancer Ther"},{"key":"3397_CR17","doi-asserted-by":"publisher","first-page":"3189","DOI":"10.1158\/0008-5472.CAN-10-3224","volume":"71","author":"CA Eide","year":"2011","unstructured":"Eide CA, Adrian LT, Tyner JW et al (2011) The ABL switch control inhibitor DCC-2036 is active against the chronic myeloid leukemia mutant BCR\u2013ABLT315I and exhibits a narrow resistance profile. Cancer Res 71:3189\u20133195. https:\/\/doi.org\/10.1158\/0008-5472.CAN-10-3224","journal-title":"Cancer Res"},{"key":"3397_CR18","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1172\/JCI35721","volume":"121","author":"AS Corbin","year":"2011","unstructured":"Corbin AS, Agarwal A, Loriaux M et al (2011) Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR\u2013ABL activity. J Clin Invest 121:396\u2013409. https:\/\/doi.org\/10.1172\/JCI35721","journal-title":"J Clin Invest"},{"key":"3397_CR19","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1200\/JCO.2012.48.5797","volume":"32","author":"P Rousselot","year":"2014","unstructured":"Rousselot P, Charbonnier A, Cony-Makhoul P et al (2014) Loss of major molecular response as a trigger for restarting tyrosine kinase inhibitor therapy in patients with chronic-phase chronic myelogenous leukemia who have stopped imatinib after durable undetectable disease. J Clin Oncol Off J Am Soc Clin Oncol 32:424\u2013430. https:\/\/doi.org\/10.1200\/JCO.2012.48.5797","journal-title":"J Clin Oncol Off J Am Soc Clin Oncol"},{"key":"3397_CR20","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.bbadis.2012.10.014","volume":"1832","author":"A Mitra","year":"2013","unstructured":"Mitra A, Sasikumar K, Parthasaradhi BVV, Radha V (2013) The tyrosine phosphatase TC48 interacts with and inactivates the oncogenic fusion protein BCR\u2013ABL but not cellular Abl. Biochim Biophys Acta BBA Mol Basis Dis 1832:275\u2013284. https:\/\/doi.org\/10.1016\/j.bbadis.2012.10.014","journal-title":"Biochim Biophys Acta BBA Mol Basis Dis"},{"key":"3397_CR21","doi-asserted-by":"publisher","first-page":"7414","DOI":"10.1073\/pnas.0900653106","volume":"106","author":"M Brehme","year":"2009","unstructured":"Brehme M, Hantschel O, Colinge J et al (2009) Charting the molecular network of the drug target BCR\u2013ABL. Proc Natl Acad Sci 106:7414\u20137419","journal-title":"Proc Natl Acad Sci"},{"key":"3397_CR22","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/S0092-8674(05)80094-7","volume":"75","author":"AM Pendergast","year":"1993","unstructured":"Pendergast AM, Quilliam LA, Cripe LD et al (1993) BCR\u2013ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein. Cell 75:175\u2013185","journal-title":"Cell"},{"key":"3397_CR23","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1016\/0092-8674(95)90277-5","volume":"82","author":"A Goga","year":"1995","unstructured":"Goga A, McLaughlin J, Afar DE et al (1995) Alternative signals to RAS for hematopoietic transformation by the BCR\u2013ABL oncogene. Cell 82:981\u2013988","journal-title":"Cell"},{"key":"3397_CR24","doi-asserted-by":"publisher","first-page":"e17020","DOI":"10.1371\/journal.pone.0017020","volume":"6","author":"M Preyer","year":"2011","unstructured":"Preyer M, Vigneri P, Wang JYJ (2011) Interplay between kinase domain autophosphorylation and F-actin binding domain in regulating imatinib sensitivity and nuclear import of BCR\u2013ABL. PLoS One 6:e17020. https:\/\/doi.org\/10.1371\/journal.pone.0017020","journal-title":"PLoS One"},{"key":"3397_CR25","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1182\/blood.V96.2.618","volume":"96","author":"S Coutinho","year":"2000","unstructured":"Coutinho S, Jahn T, Lewitzky M et al (2000) Characterization of Grb4, an adapter protein interacting with BCR\u2013ABL. Blood 96:618\u2013624","journal-title":"Blood"},{"key":"3397_CR26","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1016\/j.cellsig.2009.12.012","volume":"22","author":"C Preisinger","year":"2010","unstructured":"Preisinger C, Kolch W (2010) The BCR\u2013ABL kinase regulates the actin cytoskeleton via a GADS\/Slp-76\/Nck1 adaptor protein pathway. Cell Signal 22:848\u2013856. https:\/\/doi.org\/10.1016\/j.cellsig.2009.12.012","journal-title":"Cell Signal"},{"key":"3397_CR27","doi-asserted-by":"publisher","first-page":"30907","DOI":"10.1074\/jbc.M605902200","volume":"281","author":"MA Meyn","year":"2006","unstructured":"Meyn MA, Wilson MB, Abdi FA et al (2006) Src family kinases phosphorylate the BCR\u2013ABL SH3\u2013SH2 region and modulate BCR\u2013ABL transforming activity. J Biol Chem 281:30907\u201330916. https:\/\/doi.org\/10.1074\/jbc.M605902200","journal-title":"J Biol Chem"},{"key":"3397_CR28","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1101\/gad.8.7.783","volume":"8","author":"R Ren","year":"1994","unstructured":"Ren R, Ye Z-S, Baltimore D (1994) Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites. Genes Dev 8:783\u2013795","journal-title":"Genes Dev"},{"key":"3397_CR29","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1038\/sj.onc.1204202","volume":"20","author":"M Lewitzky","year":"2001","unstructured":"Lewitzky M, Kardinal C, Gehring NH et al (2001) The C-terminal SH3 domain of the adapter protein Grb2 binds with high affinity to sequences in Gab1 and SLP-76 which lack the SH3-typical P-X-X-P core motif. Oncogene 20:1052\u20131062. https:\/\/doi.org\/10.1038\/sj.onc.1204202","journal-title":"Oncogene"},{"key":"3397_CR30","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1038\/35067100","volume":"2","author":"CB Thien","year":"2001","unstructured":"Thien CB, Langdon WY (2001) Cbl: many adaptations to regulate protein tyrosine kinases. Nat Rev Mol Cell Biol 2:294","journal-title":"Nat Rev Mol Cell Biol"},{"key":"3397_CR31","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1038\/sj.onc.1201031","volume":"14","author":"PM Dombrosky-Ferlan","year":"1997","unstructured":"Dombrosky-Ferlan PM, Corey SJ (1997) Yeast two-hybrid in vivo association of the Src kinase Lyn with the proto-oncogene product Cbl but not with the p85 subunit of PI 3-kinase. Oncogene 14:2019","journal-title":"Oncogene"},{"key":"3397_CR32","doi-asserted-by":"publisher","first-page":"6159","DOI":"10.1074\/jbc.271.11.6159","volume":"271","author":"L Buday","year":"1996","unstructured":"Buday L, Khwaja A, Sipeki S et al (1996) Interactions of Cbl with two adaptor proteins, Grb2 and Crk, upon T cell activation. J Biol Chem 271:6159\u20136163","journal-title":"J Biol Chem"},{"key":"3397_CR33","doi-asserted-by":"crossref","first-page":"22921","DOI":"10.1016\/S0021-9258(17)31595-8","volume":"269","author":"JA Donovan","year":"1994","unstructured":"Donovan JA, Wange RL, Langdon WY, Samelson LE (1994) The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor. J Biol Chem 269:22921\u201322924","journal-title":"J Biol Chem"},{"key":"3397_CR34","doi-asserted-by":"publisher","first-page":"3571","DOI":"10.1128\/MCB.15.7.3571","volume":"15","author":"H Meisner","year":"1995","unstructured":"Meisner H, Conway BR, Hartley D, Czech MP (1995) Interactions of Cbl with Grb2 and phosphatidylinositol 3\u2032-kinase in activated Jurkat cells. Mol Cell Biol 15:3571\u20133578","journal-title":"Mol Cell Biol"},{"key":"3397_CR35","doi-asserted-by":"publisher","first-page":"3187","DOI":"10.1074\/jbc.271.6.3187","volume":"271","author":"G Panchamoorthy","year":"1996","unstructured":"Panchamoorthy G, Fukazawa T, Miyake S et al (1996) p120 is a major substrate of tyrosine phosphorylation upon B cell antigen receptor stimulation and interacts in vivo with Fyn and Syk tyrosine kinases, Grb2 and Shc adaptors, and the p85 subunit of phosphatidylinositol 3-kinase. J Biol Chem 271:3187\u20133194","journal-title":"J Biol Chem"},{"key":"3397_CR36","doi-asserted-by":"publisher","first-page":"16170","DOI":"10.1074\/jbc.272.26.16170","volume":"272","author":"A Bhat","year":"1997","unstructured":"Bhat A, Kolibaba K, Oda T et al (1997) Interactions of CBL with BCR\u2013ABL and CRKL in BCR\u2013ABL-transformed myeloid cells. J Biol Chem 272:16170\u201316175","journal-title":"J Biol Chem"},{"key":"3397_CR37","doi-asserted-by":"publisher","first-page":"e7439","DOI":"10.1371\/journal.pone.0007439","volume":"4","author":"KJ Johnson","year":"2009","unstructured":"Johnson KJ, Griswold IJ, O\u2019Hare T et al (2009) A BCR\u2013ABL mutant lacking direct binding sites for the GRB2, CBL and CRKL adapter proteins fails to induce leukemia in mice. PLoS One 4:e7439. https:\/\/doi.org\/10.1371\/journal.pone.0007439","journal-title":"PLoS One"},{"key":"3397_CR38","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/0092-8674(93)90146-h","volume":"73","author":"L Buday","year":"1993","unstructured":"Buday L, Downward J (1993) Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor. Cell 73:611\u2013620. https:\/\/doi.org\/10.1016\/0092-8674(93)90146-h","journal-title":"Cell"},{"key":"3397_CR39","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/363045a0","volume":"363","author":"SE Egan","year":"1993","unstructured":"Egan SE, Giddings BW, Brooks MW et al (1993) Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation. Nature 363:45. https:\/\/doi.org\/10.1038\/363045a0","journal-title":"Nature"},{"key":"3397_CR40","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/363085a0","volume":"363","author":"N Li","year":"1993","unstructured":"Li N, Batzer A, Daly R et al (1993) Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling. Nature 363:85\u201388. https:\/\/doi.org\/10.1038\/363085a0","journal-title":"Nature"},{"key":"3397_CR41","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/363083a0","volume":"363","author":"M Rozakis-Adcock","year":"1993","unstructured":"Rozakis-Adcock M, Fernley R, Wade J et al (1993) The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1. Nature 363:83\u201385. https:\/\/doi.org\/10.1038\/363083a0","journal-title":"Nature"},{"key":"3397_CR42","doi-asserted-by":"publisher","first-page":"18205","DOI":"10.1074\/jbc.270.31.18205","volume":"270","author":"T Trb","year":"1995","unstructured":"Trb T, Choi WE, Wolf G et al (1995) Specificity of the PTB domain of Shc for \u03b2 turn-forming pentapeptide motifs amino-terminal to phosphotyrosine. J Biol Chem 270:18205\u201318208. https:\/\/doi.org\/10.1074\/jbc.270.31.18205","journal-title":"J Biol Chem"},{"key":"3397_CR43","doi-asserted-by":"publisher","first-page":"7587","DOI":"10.1128\/MCB.13.12.7587","volume":"13","author":"JR McWHIRTER","year":"1993","unstructured":"McWHIRTER JR, Galasso DL, Wang JY (1993) A coiled-coil oligomerization domain of Bcr is essential for the transforming function of BCR\u2013ABL oncoproteins. Mol Cell Biol 13:7587\u20137595","journal-title":"Mol Cell Biol"},{"key":"3397_CR44","doi-asserted-by":"publisher","first-page":"7744","DOI":"10.1038\/sj.onc.1204978","volume":"20","author":"BB Brasher","year":"2001","unstructured":"Brasher BB, Roumiantsev S, Van Etten RA (2001) Mutational analysis of the regulatory function of the c-Abl Src homology 3 domain. Oncogene 20:7744\u20137752. https:\/\/doi.org\/10.1038\/sj.onc.1204978","journal-title":"Oncogene"},{"key":"3397_CR45","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.cell.2011.08.046","volume":"147","author":"F Grebien","year":"2011","unstructured":"Grebien F, Hantschel O, Wojcik J et al (2011) Targeting the SH2-kinase interface in BCR\u2013ABL inhibits leukemogenesis. Cell 147:306\u2013319. https:\/\/doi.org\/10.1016\/j.cell.2011.08.046","journal-title":"Cell"},{"key":"3397_CR46","doi-asserted-by":"crossref","first-page":"22925","DOI":"10.1016\/S0021-9258(17)31596-X","volume":"269","author":"T Oda","year":"1994","unstructured":"Oda T, Heaney C, Hagopian JR et al (1994) Crkl is the major tyrosine-phosphorylated protein in neutrophils from patients with chronic myelogenous leukemia. J Biol Chem 269:22925\u201322928","journal-title":"J Biol Chem"},{"key":"3397_CR47","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1182\/blood.V84.6.1731.1731","volume":"84","author":"J ten Hoeve","year":"1994","unstructured":"ten Hoeve J, Arlinghaus RB, Guo JQ et al (1994) Tyrosine phosphorylation of CRKL in philadelphia\u2009+\u2009leukemia. Blood 84:1731\u20131736","journal-title":"Blood"},{"key":"3397_CR48","doi-asserted-by":"publisher","first-page":"2912","DOI":"10.1182\/blood.V84.9.2912.2912","volume":"84","author":"GL Nichols","year":"1994","unstructured":"Nichols GL, Raines MA, Vera JC et al (1994) Identification of CRKL as the constitutively phosphorylated 39-kD tyrosine phosphoprotein in chronic myelogenous leukemia cells. Blood 84:2912\u20132918","journal-title":"Blood"},{"key":"3397_CR49","doi-asserted-by":"publisher","first-page":"2745","DOI":"10.1182\/blood.V89.8.2745","volume":"89","author":"H Odai","year":"1997","unstructured":"Odai H, Sasaki K, Iwamatsu A et al (1997) Purification and molecular cloning of SH2- and SH3-containing inositol polyphosphate-5-phosphatase, which is involved in the signaling pathway of granulocyte-macrophage colony-stimulating factor, erythropoietin, and BCR\u2013ABL. Blood 89:2745\u20132756","journal-title":"Blood"},{"key":"3397_CR50","doi-asserted-by":"publisher","first-page":"2707","DOI":"10.1182\/blood.V93.8.2707","volume":"93","author":"D Wisniewski","year":"1999","unstructured":"Wisniewski D, Strife A, Swendeman S et al (1999) A novel SH2-containing phosphatidylinositol 3, 4, 5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells. Blood 93:2707\u20132720","journal-title":"Blood"},{"key":"3397_CR51","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1182\/blood.V86.2.726.bloodjournal862726","volume":"86","author":"T Skorski","year":"1995","unstructured":"Skorski T, Kanakaraj P, Nieborowska-Skorska M et al (1995) Phosphatidylinositol-3 kinase activity is regulated by BCR\/ABL and is required for the growth of Philadelphia chromosome-positive cells. Blood 86:726\u2013736","journal-title":"Blood"},{"key":"3397_CR52","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1016\/j.exphem.2005.06.030","volume":"33","author":"S Ren","year":"2005","unstructured":"Ren S, Xue F, Feng J, Skorski T (2005) Intrinsic regulation of the interactions between the SH3 domain of p85 subunit of phosphatidylinositol-3 kinase and the protein network of BCR\/ABL oncogenic tyrosine kinase. Exp Hematol 33:1222\u20131228. https:\/\/doi.org\/10.1016\/j.exphem.2005.06.030","journal-title":"Exp Hematol"},{"key":"3397_CR53","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/S1535-6108(02)00074-0","volume":"1","author":"M Sattler","year":"2002","unstructured":"Sattler M, Mohi MG, Pride YB et al (2002) Critical role for Gab2 in transformation by BCR\/ABL. Cancer Cell 1:479\u2013492","journal-title":"Cancer Cell"},{"key":"3397_CR54","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-019-0468-y","author":"AA Mian","year":"2019","unstructured":"Mian AA, Baumann I, Liebermann M et al (2019) The phosphatase UBASH3B\/Sts-1 is a negative regulator of BCR\u2013ABL kinase activity and leukemogenesis. Leukemia. https:\/\/doi.org\/10.1038\/s41375-019-0468-y","journal-title":"Leukemia"},{"key":"3397_CR55","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1038\/leu.2017.36","volume":"31","author":"S Reckel","year":"2017","unstructured":"Reckel S, Hamelin R, Georgeon S et al (2017) Differential signaling networks of BCR\u2013ABL p210 and p190 kinases in leukemia cells defined by functional proteomics. Leukemia 31:1502\u20131512. https:\/\/doi.org\/10.1038\/leu.2017.36","journal-title":"Leukemia"},{"key":"3397_CR56","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1038\/leu.2017.61","volume":"31","author":"JA Cutler","year":"2017","unstructured":"Cutler JA, Tahir R, Sreenivasamurthy SK et al (2017) Differential signaling through p190 and p210 BCR\u2013ABL fusion proteins revealed by interactome and phosphoproteome analysis. Leukemia 31:1513\u20131524. https:\/\/doi.org\/10.1038\/leu.2017.61","journal-title":"Leukemia"},{"key":"3397_CR57","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02313-6","author":"S Reckel","year":"2017","unstructured":"Reckel S, Gehin C, Tardivon D et al (2017) Structural and functional dissection of the DH and PH domains of oncogenic BCR\u2013ABL tyrosine kinase. Nat Commun. https:\/\/doi.org\/10.1038\/s41467-017-02313-6","journal-title":"Nat Commun"},{"key":"3397_CR58","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1111\/j.1476-5381.2009.00358.x","volume":"158","author":"A Suwa","year":"2009","unstructured":"Suwa A, Yamamoto T, Sawada A et al (2009) Discovery and functional characterization of a novel small molecule inhibitor of the intracellular phosphatase, SHIP2. Br J Pharmacol 158:879\u2013887. https:\/\/doi.org\/10.1111\/j.1476-5381.2009.00358.x","journal-title":"Br J Pharmacol"},{"key":"3397_CR59","first-page":"1385","volume":"10","author":"D Harrison-Findik","year":"1995","unstructured":"Harrison-Findik D, Susa M, Varticovski L (1995) Association of phosphatidylinositol 3-kinase with SHC in chronic myelogeneous leukemia cells. Oncogene 10:1385\u20131391","journal-title":"Oncogene"},{"key":"3397_CR60","doi-asserted-by":"publisher","first-page":"25198","DOI":"10.1074\/jbc.271.41.25198","volume":"271","author":"R Salgia","year":"1996","unstructured":"Salgia R, Pisick E, Sattler M et al (1996) p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR\/ABL oncogene. J Biol Chem 271:25198\u201325203","journal-title":"J Biol Chem"},{"key":"3397_CR61","doi-asserted-by":"publisher","first-page":"33260","DOI":"10.1074\/jbc.272.52.33260","volume":"272","author":"M Warmuth","year":"1997","unstructured":"Warmuth M, Bergmann M, Priess A et al (1997) The Src family kinase Hck interacts with BCR\u2013ABL by a kinase-independent mechanism and phosphorylates the Grb2-binding site of Bcr. J Biol Chem 272:33260\u201333270","journal-title":"J Biol Chem"},{"key":"3397_CR62","doi-asserted-by":"publisher","first-page":"2281","DOI":"10.1038\/nprot.2013.143","volume":"8","author":"FA Ran","year":"2013","unstructured":"Ran FA, Hsu PD, Wright J et al (2013) Genome engineering using the CRISPR-Cas9 system. Nat Protoc 8:2281\u20132308. https:\/\/doi.org\/10.1038\/nprot.2013.143","journal-title":"Nat Protoc"},{"key":"3397_CR63","doi-asserted-by":"publisher","first-page":"W401","DOI":"10.1093\/nar\/gku410","volume":"42","author":"TG Montague","year":"2014","unstructured":"Montague TG, Cruz JM, Gagnon JA et al (2014) CHOPCHOP: a CRISPR\/Cas9 and TALEN web tool for genome editing. Nucleic Acids Res 42:W401\u2013W407. https:\/\/doi.org\/10.1093\/nar\/gku410","journal-title":"Nucleic Acids Res"},{"key":"3397_CR64","doi-asserted-by":"publisher","first-page":"4316","DOI":"10.1073\/pnas.1800338116","volume":"116","author":"M Kunova Bosakova","year":"2019","unstructured":"Kunova Bosakova M, Nita A, Gregor T et al (2019) Fibroblast growth factor receptor influences primary cilium length through an interaction with intestinal cell kinase. Proc Natl Acad Sci 116:4316\u20134325. https:\/\/doi.org\/10.1073\/pnas.1800338116","journal-title":"Proc Natl Acad Sci"}],"container-title":["Cellular and Molecular Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-019-03397-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00018-019-03397-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-019-03397-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T04:11:26Z","timestamp":1613016686000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00018-019-03397-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,9]]},"references-count":64,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["3397"],"URL":"https:\/\/doi.org\/10.1007\/s00018-019-03397-7","relation":{},"ISSN":["1420-682X","1420-9071"],"issn-type":[{"value":"1420-682X","type":"print"},{"value":"1420-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,9]]},"assertion":[{"value":"26 June 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 November 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 November 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 December 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}