{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T12:55:15Z","timestamp":1793278515461,"version":"4.5.0"},"reference-count":71,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,3,14]],"date-time":"2020-03-14T00:00:00Z","timestamp":1584144000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,3,14]],"date-time":"2020-03-14T00:00:00Z","timestamp":1584144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["R01DC016309"],"award-info":[{"award-number":["R01DC016309"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R21AI137484"],"award-info":[{"award-number":["R21AI137484"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell. Mol. Life Sci."],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1007\/s00018-020-03494-y","type":"journal-article","created":{"date-parts":[[2020,3,14]],"date-time":"2020-03-14T11:02:30Z","timestamp":1584183750000},"page":"271-286","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["Bitter taste receptors stimulate phagocytosis in human macrophages through calcium, nitric oxide, and cyclic-GMP signaling"],"prefix":"10.1007","volume":"78","author":[{"given":"Indiwari","family":"Gopallawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna R.","family":"Freund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5826-6686","authenticated-orcid":false,"given":"Robert J.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,3,14]]},"reference":[{"key":"3494_CR1","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/978-3-642-14426-4_8","volume":"52","author":"M Behrens","year":"2010","unstructured":"Behrens M, Meyerhof W (2010) Oral and extraoral bitter taste receptors. Results Probl Cell Differ 52:87\u201399. https:\/\/doi.org\/10.1007\/978-3-642-14426-4_8","journal-title":"Results Probl Cell Differ"},{"key":"3494_CR2","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/s00018-014-1736-7","volume":"72","author":"RJ Lee","year":"2015","unstructured":"Lee RJ, Cohen NA (2015) Taste receptors in innate immunity. Cell Mol Life Sci 72:217\u2013236. https:\/\/doi.org\/10.1007\/s00018-014-1736-7","journal-title":"Cell Mol Life Sci"},{"key":"3494_CR3","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.wjorl.2018.02.004","volume":"4","author":"JR Freund","year":"2018","unstructured":"Freund JR, Lee RJ (2018) Taste receptors in the upper airway. World J Otorhinolaryngol Head Neck Surg 4:67\u201376. https:\/\/doi.org\/10.1016\/j.wjorl.2018.02.004","journal-title":"World J Otorhinolaryngol Head Neck Surg"},{"key":"3494_CR4","doi-asserted-by":"publisher","DOI":"10.3390\/nu11092017","author":"RM Carey","year":"2019","unstructured":"Carey RM, Lee RJ (2019) Taste receptors in upper airway innate immunity. Nutrients. https:\/\/doi.org\/10.3390\/nu11092017","journal-title":"Nutrients"},{"key":"3494_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2017.02.002","author":"SS An","year":"2017","unstructured":"An SS, Liggett SB (2017) Taste and smell gpcrs in the lung: evidence for a previously unrecognized widespread chemosensory system. Cell Signal. https:\/\/doi.org\/10.1016\/j.cellsig.2017.02.002","journal-title":"Cell Signal"},{"key":"3494_CR6","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1165\/rcmb.2016-0373OC","volume":"56","author":"D Kim","year":"2017","unstructured":"Kim D, Woo JA, Geffken E, An SS, Liggett SB (2017) Coupling of airway smooth muscle bitter taste receptors to intracellular signaling and relaxation is via galphai1,2,3. Am J Respir Cell Mol Biol 56:762\u2013771. https:\/\/doi.org\/10.1165\/rcmb.2016-0373OC","journal-title":"Am J Respir Cell Mol Biol"},{"key":"3494_CR7","doi-asserted-by":"publisher","first-page":"9824","DOI":"10.1074\/jbc.RA117.001005","volume":"293","author":"JR Freund","year":"2018","unstructured":"Freund JR, Mansfield CJ, Doghramji LJ, Adappa ND, Palmer JN, Kennedy DW, Reed DR, Jiang P, Lee RJ (2018) Activation of airway epithelial bitter taste receptors by pseudomonas aeruginosa quinolones modulates calcium, cyclic-amp, and nitric oxide signaling. J Biol Chem 293:9824\u20139840. https:\/\/doi.org\/10.1074\/jbc.RA117.001005","journal-title":"J Biol Chem"},{"key":"3494_CR8","doi-asserted-by":"publisher","first-page":"8484","DOI":"10.1074\/jbc.M116.771949","volume":"292","author":"BM Hariri","year":"2017","unstructured":"Hariri BM, McMahon DB, Chen B, Freund JR, Mansfield CJ, Doghramji LJ, Adappa ND, Palmer JN, Kennedy DW, Reed DR, Jiang P, Lee RJ (2017) Flavones modulate respiratory epithelial innate immunity: anti-inflammatory effects and activation of the t2r14 receptor. J Biol Chem 292:8484\u20138497. https:\/\/doi.org\/10.1074\/jbc.M116.771949","journal-title":"J Biol Chem"},{"key":"3494_CR9","doi-asserted-by":"publisher","first-page":"4145","DOI":"10.1172\/JCI64240","volume":"122","author":"RJ Lee","year":"2012","unstructured":"Lee RJ, Xiong G, Kofonow JM, Chen B, Lysenko A, Jiang P, Abraham V, Doghramji L, Adappa ND, Palmer JN, Kennedy DW, Beauchamp GK, Doulias P-T, Ischiropoulos H, Kreindler JL, Reed DR, Cohen NA (2012) T2r38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection. J Clin Invest 122:4145\u20134159","journal-title":"J Clin Invest"},{"key":"3494_CR10","doi-asserted-by":"publisher","first-page":"15358","DOI":"10.1074\/jbc.M116.718544","volume":"291","author":"K Lossow","year":"2016","unstructured":"Lossow K, Hubner S, Roudnitzky N, Slack JP, Pollastro F, Behrens M, Meyerhof W (2016) Comprehensive analysis of mouse bitter taste receptors reveals different molecular receptive ranges for orthologous receptors in mice and humans. J Biol Chem 291:15358\u201315377. https:\/\/doi.org\/10.1074\/jbc.M116.718544","journal-title":"J Biol Chem"},{"key":"3494_CR11","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1021\/acsinfecdis.8b00094","volume":"4","author":"A Jaggupilli","year":"2018","unstructured":"Jaggupilli A, Singh N, Jesus VC, Duan K, Chelikani P (2018) Characterization of the binding sites for bacterial acyl homoserine lactones (ahls) on human bitter taste receptors (t2rs). ACS Infect Dis 4:1146\u20131156. https:\/\/doi.org\/10.1021\/acsinfecdis.8b00094","journal-title":"ACS Infect Dis"},{"key":"3494_CR12","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1002\/alr.21140","volume":"3","author":"ND Adappa","year":"2013","unstructured":"Adappa ND, Howland TJ, Palmer JN, Kennedy DW, Doghramji L, Lysenko A, Reed DR, Lee RJ, Cohen NA (2013) Genetics of the taste receptor t2r38 correlates with chronic rhinosinusitis necessitating surgical intervention. Int Forum Allergy Rhinol 3:184\u2013187","journal-title":"Int Forum Allergy Rhinol"},{"key":"3494_CR13","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1002\/alr.21253","volume":"4","author":"ND Adappa","year":"2014","unstructured":"Adappa ND, Zhang Z, Palmer JN, Kennedy DW, Doghramji L, Lysenko A, Reed DR, Scott T, Zhao NW, Owens D, Lee RJ, Cohen NA (2014) The bitter taste receptor t2r38 is an independent risk factor for chronic rhinosinusitis requiring sinus surgery. Int Forum Allergy Rhinol 4:3\u20137. https:\/\/doi.org\/10.1002\/alr.21253","journal-title":"Int Forum Allergy Rhinol"},{"key":"3494_CR14","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1002\/alr.21666","volume":"6","author":"ND Adappa","year":"2015","unstructured":"Adappa ND, Farquhar D, Palmer JN, Kennedy DW, Doghramji L, Morris SA, Owens D, Mansfield C, Lysenko A, Lee RJ, Cowart BJ, Reed DR, Cohen NA (2015) Tas2r38 genotype predicts surgical outcome in nonpolypoid chronic rhinosinusitis. Int Forum Allergy Rhinol 6:25\u201333. https:\/\/doi.org\/10.1002\/alr.21666","journal-title":"Int Forum Allergy Rhinol"},{"key":"3494_CR15","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1002\/alr.21275","volume":"4","author":"L Mfuna Endam","year":"2014","unstructured":"Mfuna Endam L, Filali-Mouhim A, Boisvert P, Boulet LP, Bosse Y, Desrosiers M (2014) Genetic variations in taste receptors are associated with chronic rhinosinusitis: a replication study. Int Forum Allergy Rhinol 4:200\u2013206. https:\/\/doi.org\/10.1002\/alr.21275","journal-title":"Int Forum Allergy Rhinol"},{"key":"3494_CR16","doi-asserted-by":"publisher","first-page":"90","DOI":"10.4193\/Rhin16.181","volume":"55","author":"DI Rom","year":"2017","unstructured":"Rom DI, Christensen JM, Alvarado R, Sacks R, Harvey RJ (2017) The impact of bitter taste receptor genetics on culturable bacteria in chronic rhinosinusitis. Rhinology 55:90\u201394. https:\/\/doi.org\/10.4193\/Rhin16.181","journal-title":"Rhinology"},{"key":"3494_CR17","doi-asserted-by":"publisher","first-page":"13","DOI":"10.5604\/00306657.1209438","volume":"70","author":"K Dzaman","year":"2016","unstructured":"Dzaman K, Zagor M, Sarnowska E, Krzeski A, Kantor I (2016) The correlation of tas2r38 gene variants with higher risk for chronic rhinosinusitis in polish patients. Otolaryngol Pol 70:13\u201318. https:\/\/doi.org\/10.5604\/00306657.1209438","journal-title":"Otolaryngol Pol"},{"key":"3494_CR18","doi-asserted-by":"publisher","first-page":"369","DOI":"10.3389\/fimmu.2015.00369","volume":"6","author":"S Maurer","year":"2015","unstructured":"Maurer S, Wabnitz GH, Kahle NA, Stegmaier S, Prior B, Giese T, Gaida MM, Samstag Y, Hansch GM (2015) Tasting pseudomonas aeruginosa biofilms: human neutrophils express the bitter receptor t2r38 as sensor for the quorum sensing molecule n-(3-oxododecanoyl)-l-homoserine lactone. Front Immunol 6:369. https:\/\/doi.org\/10.3389\/fimmu.2015.00369","journal-title":"Front Immunol"},{"key":"3494_CR19","doi-asserted-by":"publisher","DOI":"10.1093\/femspd\/ftw004","author":"MM Gaida","year":"2016","unstructured":"Gaida MM, Dapunt U, Hansch GM (2016) Sensing developing biofilms: the bitter receptor t2r38 on myeloid cells. Pathog Dis. https:\/\/doi.org\/10.1093\/femspd\/ftw004","journal-title":"Pathog Dis"},{"key":"3494_CR20","doi-asserted-by":"publisher","first-page":"2949","DOI":"10.3389\/fimmu.2018.02949","volume":"9","author":"HTT Tran","year":"2018","unstructured":"Tran HTT, Herz C, Ruf P, Stetter R, Lamy E (2018) Human t2r38 bitter taste receptor expression in resting and activated lymphocytes. Front Immunol 9:2949. https:\/\/doi.org\/10.3389\/fimmu.2018.02949","journal-title":"Front Immunol"},{"key":"3494_CR21","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1189\/jlb.2A0714-331RR","volume":"97","author":"A Malki","year":"2015","unstructured":"Malki A, Fiedler J, Fricke K, Ballweg I, Pfaffl MW, Krautwurst D (2015) Class i odorant receptors, tas1r and tas2r taste receptors, are markers for subpopulations of circulating leukocytes. J Leukoc Biol 97:533\u2013545. https:\/\/doi.org\/10.1189\/jlb.2A0714-331RR","journal-title":"J Leukoc Biol"},{"key":"3494_CR22","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.3389\/fphys.2019.01267","volume":"10","author":"S Grassin-Delyle","year":"2019","unstructured":"Grassin-Delyle S, Salvator H, Mantov N, Abrial C, Brollo M, Faisy C, Naline E, Couderc LJ, Devillier P (2019) Bitter taste receptors (tas2rs) in human lung macrophages: receptor expression and inhibitory effects of tas2r agonists. Front Physiol 10:1267. https:\/\/doi.org\/10.3389\/fphys.2019.01267","journal-title":"Front Physiol"},{"key":"3494_CR23","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.it.2015.01.003","volume":"36","author":"C Bogdan","year":"2015","unstructured":"Bogdan C (2015) Nitric oxide synthase in innate and adaptive immunity: an update. Trends Immunol 36:161\u2013178. https:\/\/doi.org\/10.1016\/j.it.2015.01.003","journal-title":"Trends Immunol"},{"key":"3494_CR24","doi-asserted-by":"publisher","first-page":"4492","DOI":"10.1074\/jbc.M111.315598","volume":"287","author":"Z Huang","year":"2012","unstructured":"Huang Z, Hoffmann FW, Fay JD, Hashimoto AC, Chapagain ML, Kaufusi PH, Hoffmann PR (2012) Stimulation of unprimed macrophages with immune complexes triggers a low output of nitric oxide by calcium-dependent neuronal nitric-oxide synthase. J Biol Chem 287:4492\u20134502. https:\/\/doi.org\/10.1074\/jbc.M111.315598","journal-title":"J Biol Chem"},{"key":"3494_CR25","doi-asserted-by":"publisher","first-page":"1941","DOI":"10.1002\/eji.1830240836","volume":"24","author":"N Reiling","year":"1994","unstructured":"Reiling N, Ulmer AJ, Duchrow M, Ernst M, Flad HD, Hauschildt S (1994) Nitric oxide synthase: mRNA expression of different isoforms in human monocytes\/macrophages. Eur J Immunol 24:1941\u20131944. https:\/\/doi.org\/10.1002\/eji.1830240836","journal-title":"Eur J Immunol"},{"key":"3494_CR26","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.bbrc.2003.09.039","volume":"310","author":"H M\u00fchl","year":"2003","unstructured":"M\u00fchl H, Pfeilschifter J (2003) Endothelial nitric oxide synthase: a determinant of tnf\u03b1 production by human monocytes\/macrophages. Biochem Biophys Res Commun 310:677\u2013680. https:\/\/doi.org\/10.1016\/j.bbrc.2003.09.039","journal-title":"Biochem Biophys Res Commun"},{"key":"3494_CR27","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1155\/S0962935195000482","volume":"4","author":"B Dugas","year":"1995","unstructured":"Dugas B, Paul-Eugene N, Yamaoka K, Amirand C, Damais C, Kolb JP (1995) Il-4 induces camp and cgmp in human monocytic cells. Mediators Inflamm 4:298\u2013305. https:\/\/doi.org\/10.1155\/S0962935195000482","journal-title":"Mediators Inflamm"},{"key":"3494_CR28","first-page":"615","volume":"41","author":"HH Schmidt","year":"1992","unstructured":"Schmidt HH, Warner TD, Nakane M, Forstermann U, Murad F (1992) Regulation and subcellular location of nitrogen oxide synthases in raw264.7 macrophages. Mol Pharmacol 41:615\u2013624","journal-title":"Mol Pharmacol"},{"key":"3494_CR29","doi-asserted-by":"publisher","first-page":"26480","DOI":"10.1074\/jbc.M302238200","volume":"278","author":"L Connelly","year":"2003","unstructured":"Connelly L, Jacobs AT, Palacios-Callender M, Moncada S, Hobbs AJ (2003) Macrophage endothelial nitric-oxide synthase autoregulates cellular activation and pro-inflammatory protein expression. J Biol Chem 278:26480\u201326487. https:\/\/doi.org\/10.1074\/jbc.M302238200","journal-title":"J Biol Chem"},{"key":"3494_CR30","doi-asserted-by":"publisher","first-page":"4030","DOI":"10.4049\/jimmunol.1001778","volume":"185","author":"R Fernandez-Boyanapalli","year":"2010","unstructured":"Fernandez-Boyanapalli R, McPhillips KA, Frasch SC, Janssen WJ, Dinauer MC, Riches DW, Henson PM, Byrne A, Bratton DL (2010) Impaired phagocytosis of apoptotic cells by macrophages in chronic granulomatous disease is reversed by ifn-gamma in a nitric oxide-dependent manner. J Immunol 185:4030\u20134041. https:\/\/doi.org\/10.4049\/jimmunol.1001778","journal-title":"J Immunol"},{"key":"3494_CR31","doi-asserted-by":"publisher","first-page":"7884","DOI":"10.1074\/jbc.M113.522037","volume":"289","author":"AJ Freemerman","year":"2014","unstructured":"Freemerman AJ, Johnson AR, Sacks GN, Milner JJ, Kirk EL, Troester MA, Macintyre AN, Goraksha-Hicks P, Rathmell JC, Makowski L (2014) Metabolic reprogramming of macrophages: Glucose transporter 1 (glut1)-mediated glucose metabolism drives a proinflammatory phenotype. J Biol Chem 289:7884\u20137896. https:\/\/doi.org\/10.1074\/jbc.M113.522037","journal-title":"J Biol Chem"},{"key":"3494_CR32","doi-asserted-by":"publisher","first-page":"D413","DOI":"10.1093\/nar\/gkr755","volume":"40","author":"A Wiener","year":"2012","unstructured":"Wiener A, Shudler M, Levit A, Niv MY (2012) Bitterdb: a database of bitter compounds. Nucleic Acids Res 40:D413\u2013419. https:\/\/doi.org\/10.1093\/nar\/gkr755","journal-title":"Nucleic Acids Res"},{"key":"3494_CR33","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1093\/chemse\/bjp092","volume":"35","author":"W Meyerhof","year":"2010","unstructured":"Meyerhof W, Batram C, Kuhn C, Brockhoff A, Chudoba E, Bufe B, Appendino G, Behrens M (2010) The molecular receptive ranges of human tas2r bitter taste receptors. Chem Senses 35:157\u2013170. https:\/\/doi.org\/10.1093\/chemse\/bjp092","journal-title":"Chem Senses"},{"key":"3494_CR34","doi-asserted-by":"publisher","first-page":"e1001501","DOI":"10.1371\/journal.pbio.1001501","volume":"11","author":"CH Zhang","year":"2013","unstructured":"Zhang CH, Lifshitz LM, Uy KF, Ikebe M, Fogarty KE, ZhuGe R (2013) The cellular and molecular basis of bitter tastant-induced bronchodilation. PLoS Biol 11:e1001501. https:\/\/doi.org\/10.1371\/journal.pbio.1001501","journal-title":"PLoS Biol"},{"key":"3494_CR35","doi-asserted-by":"publisher","first-page":"e94451","DOI":"10.1371\/journal.pone.0094451","volume":"9","author":"WS Roland","year":"2014","unstructured":"Roland WS, Gouka RJ, Gruppen H, Driesse M, van Buren L, Smit G, Vincken JP (2014) 6-methoxyflavanones as bitter taste receptor blockers for htas2r39. PLoS ONE 9:e94451. https:\/\/doi.org\/10.1371\/journal.pone.0094451","journal-title":"PLoS ONE"},{"key":"3494_CR36","doi-asserted-by":"publisher","first-page":"e20123","DOI":"10.1371\/journal.pone.0020123","volume":"6","author":"TA Greene","year":"2011","unstructured":"Greene TA, Alarcon S, Thomas A, Berdougo E, Doranz BJ, Breslin PA, Rucker JB (2011) Probenecid inhibits the human bitter taste receptor tas2r16 and suppresses bitter perception of salicin. PLoS ONE 6:e20123. https:\/\/doi.org\/10.1371\/journal.pone.0020123","journal-title":"PLoS ONE"},{"key":"3494_CR37","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1177\/1087057115618608","volume":"21","author":"PH Tewson","year":"2016","unstructured":"Tewson PH, Martinka S, Shaner NC, Hughes TE, Quinn AM (2016) New dag and camp sensors optimized for live-cell assays in automated laboratories. J Biomol Screen 21:298\u2013305. https:\/\/doi.org\/10.1177\/1087057115618608","journal-title":"J Biomol Screen"},{"key":"3494_CR38","doi-asserted-by":"publisher","first-page":"e0122513","DOI":"10.1371\/journal.pone.0122513","volume":"10","author":"J Klarenbeek","year":"2015","unstructured":"Klarenbeek J, Goedhart J, van Batenburg A, Groenewald D, Jalink K (2015) Fourth-generation Epac-based FRET sensors for cAMP feature exceptional brightness, photostability and dynamic range: characterization of dedicated sensors for FLIM, for ratiometry and with high affinity. PLoS ONE 10:e0122513. https:\/\/doi.org\/10.1371\/journal.pone.0122513","journal-title":"PLoS ONE"},{"key":"3494_CR39","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1039\/c0mb00079e","volume":"7","author":"C Depry","year":"2011","unstructured":"Depry C, Allen MD, Zhang J (2011) Visualization of PKA activity in plasma membrane microdomains. Mol Biosyst 7:52\u201358. https:\/\/doi.org\/10.1039\/c0mb00079e","journal-title":"Mol Biosyst"},{"key":"3494_CR40","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1084\/jem.20151570","volume":"213","author":"LA O'Neill","year":"2016","unstructured":"O'Neill LA, Pearce EJ (2016) Immunometabolism governs dendritic cell and macrophage function. J Exp Med 213:15\u201323. https:\/\/doi.org\/10.1084\/jem.20151570","journal-title":"J Exp Med"},{"key":"3494_CR41","doi-asserted-by":"publisher","first-page":"C615","DOI":"10.1152\/ajpcell.00249.2006","volume":"292","author":"A Mayevsky","year":"2007","unstructured":"Mayevsky A, Rogatsky GG (2007) Mitochondrial function in vivo evaluated by NADH fluorescence: from animal models to human studies. Am J Physiol Cell Physiol 292:C615\u2013640. https:\/\/doi.org\/10.1152\/ajpcell.00249.2006","journal-title":"Am J Physiol Cell Physiol"},{"key":"3494_CR42","doi-asserted-by":"crossref","first-page":"3562","DOI":"10.4049\/jimmunol.160.7.3562","volume":"160","author":"AG Rossi","year":"1998","unstructured":"Rossi AG, McCutcheon JC, Roy N, Chilvers ER, Haslett C, Dransfield I (1998) Regulation of macrophage phagocytosis of apoptotic cells by camp. J Immunol 160:3562\u20133568","journal-title":"J Immunol"},{"key":"3494_CR43","doi-asserted-by":"publisher","first-page":"2530","DOI":"10.1128\/IAI.00905-08","volume":"77","author":"LA Yeager","year":"2009","unstructured":"Yeager LA, Chopra AK, Peterson JW (2009) Bacillus anthracis edema toxin suppresses human macrophage phagocytosis and cytoskeletal remodeling via the protein kinase a and exchange protein activated by cyclic amp pathways. Infect Immun 77:2530\u20132543. https:\/\/doi.org\/10.1128\/IAI.00905-08","journal-title":"Infect Immun"},{"key":"3494_CR44","doi-asserted-by":"publisher","first-page":"pe37","DOI":"10.1126\/scisignal.275pe37","volume":"2","author":"M Peters-Golden","year":"2009","unstructured":"Peters-Golden M (2009) Putting on the brakes: cyclic amp as a multipronged controller of macrophage function. Sci Signal 2:pe37. https:\/\/doi.org\/10.1126\/scisignal.275pe37","journal-title":"Sci Signal"},{"key":"3494_CR45","doi-asserted-by":"publisher","first-page":"595","DOI":"10.4049\/jimmunol.174.2.595","volume":"174","author":"DM Aronoff","year":"2005","unstructured":"Aronoff DM, Canetti C, Serezani CH, Luo M, Peters-Golden M (2005) Cutting edge: macrophage inhibition by cyclic amp (camp): differential roles of protein kinase a and exchange protein directly activated by camp-1. J Immunol 174:595\u2013599. https:\/\/doi.org\/10.4049\/jimmunol.174.2.595","journal-title":"J Immunol"},{"key":"3494_CR46","doi-asserted-by":"publisher","first-page":"10454","DOI":"10.1021\/jf403387p","volume":"61","author":"WS Roland","year":"2013","unstructured":"Roland WS, van Buren L, Gruppen H, Driesse M, Gouka RJ, Smit G, Vincken JP (2013) Bitter taste receptor activation by flavonoids and isoflavonoids: modeled structural requirements for activation of htas2r14 and htas2r39. J Agric Food Chem 61:10454\u201310466. https:\/\/doi.org\/10.1021\/jf403387p","journal-title":"J Agric Food Chem"},{"key":"3494_CR47","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1124\/jpet.111.184416","volume":"339","author":"EA Townsend","year":"2011","unstructured":"Townsend EA, Meuchel LW, Thompson MA, Pabelick CM, Prakash YS (2011) Estrogen increases nitric-oxide production in human bronchial epithelium. J Pharmacol Exp Ther 339:815\u2013824. https:\/\/doi.org\/10.1124\/jpet.111.184416","journal-title":"J Pharmacol Exp Ther"},{"key":"3494_CR48","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1177\/1753425913503386","volume":"20","author":"RJ Lee","year":"2014","unstructured":"Lee RJ, Chen B, Redding KM, Margolskee RF, Cohen NA (2014) Mouse nasal epithelial innate immune responses to pseudomonas aeruginosa quorum-sensing molecules require taste signaling components. Innate Immun 20:606\u2013617. https:\/\/doi.org\/10.1177\/1753425913503386","journal-title":"Innate Immun"},{"key":"3494_CR49","doi-asserted-by":"publisher","first-page":"2014","DOI":"10.1080\/09168451.2016.1184558","volume":"80","author":"Y Kuroda","year":"2016","unstructured":"Kuroda Y, Ikeda R, Yamazaki T, Ito K, Uda K, Wakabayashi K, Watanabe T (2016) Activation of human bitter taste receptors by polymethoxylated flavonoids. Biosci Biotechnol Biochem 80:2014\u20132017. https:\/\/doi.org\/10.1080\/09168451.2016.1184558","journal-title":"Biosci Biotechnol Biochem"},{"key":"3494_CR50","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1111\/cbdd.13089","volume":"91","author":"M Behrens","year":"2017","unstructured":"Behrens M, Gu M, Fan S, Huang C, Meyerhof W (2017) Bitter substances from plants used in traditional Chinese medicine exert biased activation of human bitter taste receptors. Chem Biol Drug Des 91:422\u2013433. https:\/\/doi.org\/10.1111\/cbdd.13089","journal-title":"Chem Biol Drug Des"},{"key":"3494_CR51","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1096\/fj.13-242594","volume":"28","author":"A Levit","year":"2014","unstructured":"Levit A, Nowak S, Peters M, Wiener A, Meyerhof W, Behrens M, Niv MY (2014) The bitter pill: clinical drugs that activate the human bitter taste receptor TAS2R14. FASEB J 28:1181\u20131197. https:\/\/doi.org\/10.1096\/fj.13-242594","journal-title":"FASEB J"},{"key":"3494_CR52","doi-asserted-by":"publisher","first-page":"4827","DOI":"10.1096\/fj.12-215087","volume":"26","author":"AA Clark","year":"2012","unstructured":"Clark AA, Liggett SB, Munger SD (2012) Extraoral bitter taste receptors as mediators of off-target drug effects. FASEB J 26:4827\u20134831. https:\/\/doi.org\/10.1096\/fj.12-215087","journal-title":"FASEB J"},{"key":"3494_CR53","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1006\/cimm.1996.0290","volume":"174","author":"CD Jun","year":"1996","unstructured":"Jun CD, Han MK, Kim UH, Chung HT (1996) Nitric oxide induces adp-ribosylation of actin in murine macrophages: association with the inhibition of pseudopodia formation, phagocytic activity, and adherence on a laminin substratum. Cell Immunol 174:25\u201334. https:\/\/doi.org\/10.1006\/cimm.1996.0290","journal-title":"Cell Immunol"},{"key":"3494_CR54","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/s0167-4889(01)00090-8","volume":"1539","author":"X Ke","year":"2001","unstructured":"Ke X, Terashima M, Nariai Y, Nakashima Y, Nabika T, Tanigawa Y (2001) Nitric oxide regulates actin reorganization through cGMP and Ca(2+)\/calmodulin in raw 264.7 cells. Biochim Biophys Acta 1539:101\u2013113. https:\/\/doi.org\/10.1016\/s0167-4889(01)00090-8","journal-title":"Biochim Biophys Acta"},{"key":"3494_CR55","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1007\/s00109-014-1236-0","volume":"93","author":"WT Liao","year":"2015","unstructured":"Liao WT, You HL, Li C, Chang JG, Chang SJ, Chen CJ (2015) Cyclic GMP-dependent protein kinase ii is necessary for macrophage m1 polarization and phagocytosis via toll-like receptor 2. J Mol Med (Berl) 93:523\u2013533. https:\/\/doi.org\/10.1007\/s00109-014-1236-0","journal-title":"J Mol Med (Berl)"},{"key":"3494_CR56","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/S0021-9150(01)00687-6","volume":"162","author":"A Heinloth","year":"2002","unstructured":"Heinloth A, Brune B, Fischer B, Galle J (2002) Nitric oxide prevents oxidised ldl-induced p53 accumulation, cytochrome c translocation, and apoptosis in macrophages via guanylate cyclase stimulation. Atherosclerosis 162:93\u2013101","journal-title":"Atherosclerosis"},{"key":"3494_CR57","doi-asserted-by":"publisher","first-page":"175","DOI":"10.4049\/jimmunol.165.1.175","volume":"165","author":"AK Kiemer","year":"2000","unstructured":"Kiemer AK, Hartung T, Vollmar AM (2000) Cgmp-mediated inhibition of tnf-alpha production by the atrial natriuretic peptide in murine macrophages. J Immunol 165:175\u2013181","journal-title":"J Immunol"},{"key":"3494_CR58","doi-asserted-by":"publisher","first-page":"2827","DOI":"10.1161\/ATVBAHA.111.236554","volume":"31","author":"P Handa","year":"2011","unstructured":"Handa P, Tateya S, Rizzo NO, Cheng AM, Morgan-Stevenson V, Han CY, Clowes AW, Daum G, O'Brien KD, Schwartz MW, Chait A, Kim F (2011) Reduced vascular nitric oxide-cgmp signaling contributes to adipose tissue inflammation during high-fat feeding. Arterioscler Thromb Vasc Biol 31:2827\u20132835. https:\/\/doi.org\/10.1161\/ATVBAHA.111.236554","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"3494_CR59","doi-asserted-by":"publisher","first-page":"2792","DOI":"10.2337\/db11-0255","volume":"60","author":"S Tateya","year":"2011","unstructured":"Tateya S, Rizzo NO, Handa P, Cheng AM, Morgan-Stevenson V, Daum G, Clowes AW, Morton GJ, Schwartz MW, Kim F (2011) Endothelial no\/cgmp\/vasp signaling attenuates Kupffer cell activation and hepatic insulin resistance induced by high-fat feeding. Diabetes 60:2792\u20132801. https:\/\/doi.org\/10.2337\/db11-0255","journal-title":"Diabetes"},{"key":"3494_CR60","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1111\/j.1524-475X.2009.00509.x","volume":"17","author":"MR Metukuri","year":"2009","unstructured":"Metukuri MR, Namas R, Gladstone C, Clermont T, Jefferson B, Barclay D, Hermus L, Billiar TR, Zamora R, Vodovotz Y (2009) Activation of latent transforming growth factor-beta1 by nitric oxide in macrophages: role of soluble guanylate cyclase and map kinases. Wound Repair Regen 17:578\u2013588. https:\/\/doi.org\/10.1111\/j.1524-475X.2009.00509.x","journal-title":"Wound Repair Regen"},{"key":"3494_CR61","doi-asserted-by":"publisher","first-page":"2619","DOI":"10.4049\/jimmunol.169.5.2619","volume":"169","author":"A Von Knethen","year":"2002","unstructured":"Von Knethen A, Brune B (2002) Activation of peroxisome proliferator-activated receptor gamma by nitric oxide in monocytes\/macrophages down-regulates p47phox and attenuates the respiratory burst. J Immunol 169:2619\u20132626","journal-title":"J Immunol"},{"key":"3494_CR62","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1089\/ars.2012.4785","volume":"19","author":"B Brune","year":"2013","unstructured":"Brune B, Dehne N, Grossmann N, Jung M, Namgaladze D, Schmid T, von Knethen A, Weigert A (2013) Redox control of inflammation in macrophages. Antioxid Redox Signal 19:595\u2013637. https:\/\/doi.org\/10.1089\/ars.2012.4785","journal-title":"Antioxid Redox Signal"},{"key":"3494_CR63","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/0167-0115(94)90543-6","volume":"54","author":"M Ichinose","year":"1994","unstructured":"Ichinose M, Sawada M, Maeno T (1994) Inhibitory effect of vasoactive intestinal peptide (vip) on phagocytosis in mouse peritoneal macrophages. Regul Pept 54:457\u2013466. https:\/\/doi.org\/10.1016\/0167-0115(94)90543-6","journal-title":"Regul Pept"},{"key":"3494_CR64","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/0167-0115(92)90084-8","volume":"40","author":"DK Litwin","year":"1992","unstructured":"Litwin DK, Wilson AK, Said SI (1992) Vasoactive intestinal polypeptide (vip) inhibits rat alveolar macrophage phagocytosis and chemotaxis in vitro. Regul Pept 40:63\u201374. https:\/\/doi.org\/10.1016\/0167-0115(92)90084-8","journal-title":"Regul Pept"},{"key":"3494_CR65","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/0169-328X(94)90047-7","volume":"22","author":"S Takami","year":"1994","unstructured":"Takami S, Getchell TV, McLaughlin SK, Margolskee RF, Getchell ML (1994) Human taste cells express the g protein alpha-gustducin and neuron-specific enolase. Brain Res Mol Brain Res 22:193\u2013203","journal-title":"Brain Res Mol Brain Res"},{"key":"3494_CR66","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1038\/357563a0","volume":"357","author":"SK McLaughlin","year":"1992","unstructured":"McLaughlin SK, McKinnon PJ, Margolskee RF (1992) Gustducin is a taste-cell-specific g protein closely related to the transducins. Nature 357:563\u2013569. https:\/\/doi.org\/10.1038\/357563a0","journal-title":"Nature"},{"key":"3494_CR67","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1152\/physrev.00035.2006","volume":"87","author":"JK Foskett","year":"2007","unstructured":"Foskett JK, White C, Cheung KH, Mak DO (2007) Inositol trisphosphate receptor ca2+ release channels. Physiol Rev 87:593\u2013658","journal-title":"Physiol Rev"},{"key":"3494_CR68","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1042\/bst0310954","volume":"31","author":"DI Yule","year":"2003","unstructured":"Yule DI, Straub SV, Bruce JI (2003) Modulation of ca2+ oscillations by phosphorylation of ins(1,4,5)p3 receptors. Biochem Soc Trans 31:954\u2013957","journal-title":"Biochem Soc Trans"},{"issue":"547\u2013561","key":"3494_CR69","doi-asserted-by":"publisher","first-page":"e510","DOI":"10.1016\/j.neuron.2018.03.043","volume":"98","author":"Z Ma","year":"2018","unstructured":"Ma Z, Taruno A, Ohmoto M, Jyotaki M, Lim JC, Miyazaki H, Niisato N, Marunaka Y, Lee RJ, Hoff H, Payne R, Demuro A, Parker I, Mitchell CH, Henao-Mejia J, Tanis JE, Matsumoto I, Tordoff MG, Foskett JK (2018) Calhm3 is essential for rapid ion channel-mediated purinergic neurotransmission of gpcr-mediated tastes. Neuron 98(547\u2013561):e510. https:\/\/doi.org\/10.1016\/j.neuron.2018.03.043","journal-title":"Neuron"},{"key":"3494_CR70","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1096\/fj.201700114RRR","volume":"32","author":"DB McMahon","year":"2018","unstructured":"McMahon DB, Workman AD, Kohanski MA, Carey RM, Freund JR, Hariri BM, Chen B, Doghramji LJ, Adappa ND, Palmer JN, Kennedy DW, Lee RJ (2018) Protease-activated receptor 2 activates airway apical membrane chloride permeability and increases ciliary beating. FASEB J 32:155\u2013167. https:\/\/doi.org\/10.1096\/fj.201700114RRR","journal-title":"FASEB J"},{"key":"3494_CR71","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aam7703","author":"RJ Lee","year":"2017","unstructured":"Lee RJ, Hariri BM, McMahon DB, Chen B, Doghramji L, Adappa ND, Palmer JN, Kennedy DW, Jiang P, Margolskee RF, Cohen NA (2017) Bacterial d-amino acids suppress sinonasal innate immunity through sweet taste receptors in solitary chemosensory cells. Sci Signal. https:\/\/doi.org\/10.1126\/scisignal.aam7703","journal-title":"Sci Signal"}],"container-title":["Cellular and Molecular Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-020-03494-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00018-020-03494-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-020-03494-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T13:19:13Z","timestamp":1695907153000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00018-020-03494-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,14]]},"references-count":71,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["3494"],"URL":"https:\/\/doi.org\/10.1007\/s00018-020-03494-y","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/776344","asserted-by":"object"}]},"ISSN":["1420-682X","1420-9071"],"issn-type":[{"value":"1420-682X","type":"print"},{"value":"1420-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,14]]},"assertion":[{"value":"28 September 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 January 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 February 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 March 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}