{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T21:32:26Z","timestamp":1776115946434,"version":"3.50.1"},"reference-count":119,"publisher":"Springer Science and Business Media LLC","issue":"23","license":[{"start":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T00:00:00Z","timestamp":1590537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T00:00:00Z","timestamp":1590537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Ministerio de Educaci\u00f3n y Formaci\u00f3n Profesional","award":["FPU18\/00845"],"award-info":[{"award-number":["FPU18\/00845"]}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"crossref","award":["SAF2016-75228-R"],"award-info":[{"award-number":["SAF2016-75228-R"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell. Mol. Life Sci."],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Members of the dual-specificity tyrosine-regulated kinase (DYRKs) subfamily possess a distinctive capacity to phosphorylate tyrosine, serine, and threonine residues. Among the DYRK class II members, DYRK2 is considered a unique protein due to its role in disease. According to the post-transcriptional and post-translational modifications, DYRK2 expression greatly differs among human tissues. Regarding its mechanism of action, this kinase performs direct phosphorylation on its substrates or acts as a priming kinase, enabling subsequent substrate phosphorylation by GSK3\u03b2. Moreover, DYRK2 acts as a scaffold for the EDVP E3 ligase complex during the G2\/M phase of cell cycle. DYRK2 functions such as cell survival, cell development, cell differentiation, proteasome regulation, and microtubules were studied in complete detail in this review. We have also gathered available information from different bioinformatic resources to show DYRK2 interactome, normal and tumoral tissue expression, and recurrent cancer mutations. Then, here we present an innovative approach to clarify DYRK2 functionality and importance. DYRK2 roles in diseases have been studied in detail, highlighting this kinase as a key protein in cancer development. First, DYRK2 regulation of c-Jun, c-Myc, Rpt3, TERT, and katanin p60 reveals the implication of this kinase in cell-cycle-mediated cancer development. Additionally, depletion of this kinase correlated with reduced apoptosis, with consequences on cancer patient response to chemotherapy. Other functions like cancer stem cell formation and epithelial\u2013mesenchymal transition regulation are also controlled by DYRK2. Furthermore, the pharmacological modulation of this protein by different inhibitors (harmine, curcumine, LDN192960, and ID-8) has enabled to clarify DYRK2 functionality.<\/jats:p>","DOI":"10.1007\/s00018-020-03556-1","type":"journal-article","created":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T08:02:22Z","timestamp":1590566542000},"page":"4747-4763","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Updating dual-specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2): molecular basis, functions and role in diseases"],"prefix":"10.1007","volume":"77","author":[{"given":"Alejandro","family":"Correa-S\u00e1ez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Jim\u00e9nez-Izquierdo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mart\u00edn","family":"Garrido-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosario","family":"Morrugares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5338-535X","authenticated-orcid":false,"given":"Marco A.","family":"Calzado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,5,27]]},"reference":[{"key":"3556_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/s0079-6603(08)60503-6","author":"W Becker","year":"1998","unstructured":"Becker W, Joost HG (1998) Structural and functional characteristics of Dyrk, a novel subfamily of protein kinases with dual specificity. Progr Nucleic Acid Res Mol Biol. https:\/\/doi.org\/10.1016\/s0079-6603(08)60503-6","journal-title":"Progr Nucleic Acid Res Mol Biol"},{"issue":"12","key":"3556_CR2","doi-asserted-by":"publisher","first-page":"R488","DOI":"10.1016\/j.cub.2015.02.067","volume":"25","author":"U Soppa","year":"2015","unstructured":"Soppa U, Becker W (2015) DYRK protein kinases. Curr Biol 25(12):R488\u2013489. https:\/\/doi.org\/10.1016\/j.cub.2015.02.067","journal-title":"Curr Biol"},{"issue":"2","key":"3556_CR3","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1096\/fj.10-165837","volume":"25","author":"S Aranda","year":"2011","unstructured":"Aranda S, Laguna A, de la Luna S (2011) DYRK family of protein kinases: evolutionary relationships, biochemical properties, and functional roles. FASEB J 25(2):449\u2013462. https:\/\/doi.org\/10.1096\/fj.10-165837","journal-title":"FASEB J"},{"issue":"6","key":"3556_CR4","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1016\/j.str.2013.03.012","volume":"21","author":"M Soundararajan","year":"2013","unstructured":"Soundararajan M, Roos AK, Savitsky P, Filippakopoulos P, Kettenbach AN, Olsen JV, Gerber SA, Eswaran J, Knapp S, Elkins JM (2013) Structures of Down syndrome kinases, DYRKs, reveal mechanisms of kinase activation and substrate recognition. Structure 21(6):986\u2013996. https:\/\/doi.org\/10.1016\/j.str.2013.03.012","journal-title":"Structure"},{"issue":"4","key":"3556_CR5","doi-asserted-by":"publisher","first-page":"2431","DOI":"10.1074\/jbc.275.4.2431","volume":"275","author":"S Himpel","year":"2000","unstructured":"Himpel S, Tegge W, Frank R, Leder S, Joost H-G, Becker W (2000) Specificity determinants of substrate recognition by the protein kinase DYRK1A. J Biol Chem 275(4):2431\u20132438. https:\/\/doi.org\/10.1074\/jbc.275.4.2431","journal-title":"J Biol Chem"},{"issue":"6","key":"3556_CR6","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1016\/j.cell.2005.03.034","volume":"121","author":"PA Lochhead","year":"2005","unstructured":"Lochhead PA, Sibbet G, Morrice N, Cleghon V (2005) Activation-loop autophosphorylation is mediated by a novel transitional intermediate form of DYRKs. Cell 121(6):925\u2013936. https:\/\/doi.org\/10.1016\/j.cell.2005.03.034","journal-title":"Cell"},{"issue":"3","key":"3556_CR7","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1016\/j.cell.2009.08.047","volume":"139","author":"KC-C Cheng","year":"2009","unstructured":"Cheng KC-C, Klancer R, Singson A, Seydoux G (2009) Regulation of MBK-2\/DYRK by CDK-1 and the pseudophosphatases EGG-4 and EGG-5 during the oocyte-to-embryo transition. Cell 139(3):560\u2013572. https:\/\/doi.org\/10.1016\/j.cell.2009.08.047","journal-title":"Cell"},{"issue":"20","key":"3556_CR8","doi-asserted-by":"publisher","first-page":"1752","DOI":"10.1016\/j.cub.2009.09.015","volume":"19","author":"JM Parry","year":"2009","unstructured":"Parry JM, Velarde NV, Lefkovith AJ, Zegarek MH, Hang JS, Ohm J, Klancer R, Maruyama R, Druzhinina MK, Grant BD, Piano F, Singson A (2009) EGG-4 and EGG-5 link events of the oocyte-to-embryo transition with meiotic progression in C. elegans. Curr Biol 19(20):1752\u20131757. https:\/\/doi.org\/10.1016\/j.cub.2009.09.015","journal-title":"Curr Biol"},{"issue":"1","key":"3556_CR9","doi-asserted-by":"publisher","first-page":"e29702","DOI":"10.1371\/journal.pone.0029702","volume":"7","author":"J Han","year":"2012","unstructured":"Han J, Miranda-Saavedra D, Luebbering N, Singh A, Sibbet G, Ferguson MAJ, Cleghon V (2012) Deep evolutionary conservation of an intramolecular protein kinase activation mechanism. PLoS ONE 7(1):e29702. https:\/\/doi.org\/10.1371\/journal.pone.0029702","journal-title":"PLoS ONE"},{"issue":"40","key":"3556_CR10","doi-asserted-by":"publisher","first-page":"25893","DOI":"10.1074\/jbc.273.40.25893","volume":"273","author":"W Becker","year":"1998","unstructured":"Becker W, Weber Y, Wetzel K, Eirmbter K, Tejedor FJ, Joost H-G (1998) Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases. J Biol Chem 273(40):25893\u201325902. https:\/\/doi.org\/10.1074\/jbc.273.40.25893","journal-title":"J Biol Chem"},{"issue":"Pt 2","key":"3556_CR11","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1042\/BJ20030500","volume":"374","author":"PA Lochhead","year":"2003","unstructured":"Lochhead PA, Sibbet G, Kinstrie R, Cleghon T, Rylatt M, Morrison DK, Cleghon V (2003) dDYRK2: a novel dual-specificity tyrosine-phosphorylation-regulated kinase in Drosophila. Biochem J 374(Pt 2):381\u2013391. https:\/\/doi.org\/10.1042\/BJ20030500","journal-title":"Biochem J"},{"issue":"3","key":"3556_CR12","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1101\/gr.5.3.272","volume":"5","author":"R Houlgatte","year":"1995","unstructured":"Houlgatte R, Mariage-Samson R, Duprat S, Tessier A, Bentolila S, Lamy B, Auffray C (1995) The Genexpress Index: a resource for gene discovery and the genic map of the human genome. Genome Res 5(3):272\u2013304. https:\/\/doi.org\/10.1101\/gr.5.3.272","journal-title":"Genome Res"},{"issue":"32","key":"3556_CR13","doi-asserted-by":"publisher","first-page":"8155","DOI":"10.1073\/pnas.1806797115","volume":"115","author":"S Banerjee","year":"2018","unstructured":"Banerjee S, Ji C, Mayfield JE, Goel A, Xiao J, Dixon JE, Guo X (2018) Ancient drug curcumin impedes 26S proteasome activity by direct inhibition of dual-specificity tyrosine-regulated kinase 2. Proc Natl Acad Sci USA 115(32):8155\u20138160. https:\/\/doi.org\/10.1073\/pnas.1806797115","journal-title":"Proc Natl Acad Sci USA"},{"issue":"49","key":"3556_CR14","doi-asserted-by":"publisher","first-page":"24881","DOI":"10.1073\/pnas.1912033116","volume":"116","author":"S Banerjee","year":"2019","unstructured":"Banerjee S, Wei T, Wang J, Lee JJ, Gutierrez HL, Chapman O, Wiley SE, Mayfield JE, Tandon V, Juarez EF, Chavez L, Liang R, Sah RL, Costello C, Mesirov JP, de la Vega L, Cooper KL, Dixon JE, Xiao J, Lei X (2019) Inhibition of dual-specificity tyrosine phosphorylation-regulated kinase 2 perturbs 26S proteasome-addicted neoplastic progression. Proc Natl Acad Sci USA 116(49):24881\u201324891. https:\/\/doi.org\/10.1073\/pnas.1912033116","journal-title":"Proc Natl Acad Sci USA"},{"issue":"111","key":"3556_CR15","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1126\/scisignal.2000579","volume":"3","author":"R Kinstrie","year":"2010","unstructured":"Kinstrie R, Luebbering N, Miranda-Saavedra D, Sibbet G, Han J, Lochhead PA, Cleghon V (2010) Characterization of a domain that transiently converts class 2 DYRKs into intramolecular tyrosine kinases. Sci Signal 3(111):16. https:\/\/doi.org\/10.1126\/scisignal.2000579","journal-title":"Sci Signal"},{"key":"3556_CR16","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/978-3-7091-6721-2_12","volume":"67","author":"J Galceran","year":"2003","unstructured":"Galceran J, de Graaf K, Tejedor FJ, Becker W (2003) The MNB\/DYRK1A protein kinase: genetic and biochemical properties. J Neural Transm Suppl 67:139\u2013148. https:\/\/doi.org\/10.1007\/978-3-7091-6721-2_12","journal-title":"J Neural Transm Suppl"},{"issue":"7","key":"3556_CR17","doi-asserted-by":"publisher","first-page":"4909","DOI":"10.1074\/jbc.M109.042341","volume":"285","author":"N Taira","year":"2010","unstructured":"Taira N, Yamamoto H, Yamaguchi T, Miki Y, Yoshida K (2010) ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage. J Biol Chem 285(7):4909\u20134919. https:\/\/doi.org\/10.1074\/jbc.M109.042341","journal-title":"J Biol Chem"},{"issue":"22","key":"3556_CR18","doi-asserted-by":"publisher","first-page":"1960","DOI":"10.1182\/blood.2018875922","volume":"134","author":"CS Park","year":"2019","unstructured":"Park CS, Lewis AH, Chen TJ, Bridges CS, Shen Y, Suppipat K, Puppi M, Tomolonis JA, Pang PD, Mistretta T-A, Ma L, Green MR, Rau R, Lacorazza HD (2019) A KLF4-DYRK2-mediated pathway regulating self-renewal in CML stem cells. Blood 134(22):1960\u20131972. https:\/\/doi.org\/10.1182\/blood.2018875922","journal-title":"Blood"},{"key":"3556_CR19","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2020.5020","author":"T Kumamoto","year":"2020","unstructured":"Kumamoto T, Yamada K, Yoshida S, Aoki K, Hirooka S, Eto K, Yanaga K, Yoshida K (2020) Impairment of DYRK2 by DNMT1-mediated transcription augments carcinogenesis in human colorectal cancer. Int J Oncol. https:\/\/doi.org\/10.3892\/ijo.2020.5020","journal-title":"Int J Oncol"},{"issue":"4","key":"3556_CR20","doi-asserted-by":"publisher","first-page":"e91","DOI":"10.1016\/j.jamcollsurg.2019.08.961","volume":"229","author":"T Kumamoto","year":"2019","unstructured":"Kumamoto T, Yamada K, Yoshida S, Aoki K, Yanaga K, Yoshida K (2019) DNA methylation of dual-specificity tyrosine-regulated kinase 2 (DYRK2) promoter regulates proliferation of human colorectal cancer. J Am Coll Surg 229(4):e91. https:\/\/doi.org\/10.1016\/j.jamcollsurg.2019.08.961","journal-title":"J Am Coll Surg"},{"issue":"4","key":"3556_CR21","doi-asserted-by":"publisher","first-page":"339","DOI":"10.4161\/rna.28300","volume":"11","author":"J Wang","year":"2014","unstructured":"Wang J, Jia Z, Zhang C, Sun M, Wang W, Chen P, Ma K, Zhang Y, Li X, Zhou C (2014) miR-499 protects cardiomyocytes from H 2O 2-induced apoptosis via its effects on Pdcd4 and Pacs2. RNA Biol 11(4):339\u2013350. https:\/\/doi.org\/10.4161\/rna.28300","journal-title":"RNA Biol"},{"key":"3556_CR22","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.2147\/OTT.S125724","volume":"10","author":"Y Wang","year":"2017","unstructured":"Wang Y, Sun J, Wei X, Luan L, Zeng X, Wang C, Zhao W (2017) Decrease of miR-622 expression suppresses migration and invasion by targeting regulation of DYRK2 in colorectal cancer cells. Onco Targets Ther 10:1091\u20131100. https:\/\/doi.org\/10.2147\/OTT.S125724","journal-title":"Onco Targets Ther"},{"issue":"12","key":"3556_CR23","first-page":"4350","volume":"10","author":"J Yang","year":"2018","unstructured":"Yang J, Yu X, Xue F, Li Y, Liu W, Zhang S (2018) Exosomes derived from cardiomyocytes promote cardiac fibrosis via myocyte-fibroblast cross-talk. Am J Transl Res 10(12):4350\u20134366","journal-title":"Am J Transl Res"},{"key":"3556_CR24","doi-asserted-by":"publisher","unstructured":"Wang Y-J, Yue M, Guo K, Wu S-J, Tian Y-G (2018) The miR-338\u20133p involve in response to acute radiation syndrome by targeting DYRK2 in Tibet minipig. bioRxiv:506444. https:\/\/doi.org\/10.1101\/506444","DOI":"10.1101\/506444"},{"issue":"11","key":"3556_CR25","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1021\/acschemneuro.6b00222","volume":"7","author":"S Haenisch","year":"2016","unstructured":"Haenisch S, von Ruden EL, Wahmkow H, Rettenbeck ML, Michler C, Russmann V, Bruckmueller H, Waetzig V, Cascorbi I, Potschka H (2016) miRNA-187-3p-mediated regulation of the KCNK10\/TREK-2 potassium channel in a rat epilepsy model. ACS Chem Neurosci 7(11):1585\u20131594. https:\/\/doi.org\/10.1021\/acschemneuro.6b00222","journal-title":"ACS Chem Neurosci"},{"issue":"5","key":"3556_CR26","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/j.molcel.2004.08.024","volume":"15","author":"B Nolen","year":"2004","unstructured":"Nolen B, Taylor S, Ghosh G (2004) Regulation of protein kinases; controlling activity through activation segment conformation. Mol Cell 15(5):661\u2013675. https:\/\/doi.org\/10.1016\/j.molcel.2004.08.024","journal-title":"Mol Cell"},{"issue":"28","key":"3556_CR27","doi-asserted-by":"publisher","first-page":"25040","DOI":"10.1074\/jbc.M203257200","volume":"277","author":"S Lim","year":"2002","unstructured":"Lim S, Jin K, Friedman E (2002) Mirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1alpha. J Biol Chem 277(28):25040\u201325046. https:\/\/doi.org\/10.1074\/jbc.M203257200","journal-title":"J Biol Chem"},{"key":"3556_CR28","doi-asserted-by":"publisher","first-page":"11391","DOI":"10.1038\/ncomms11391","volume":"7","author":"I Kii","year":"2016","unstructured":"Kii I, Sumida Y, Goto T, Sonamoto R, Okuno Y, Yoshida S, Kato-Sumida T, Koike Y, Abe M, Nonaka Y, Ikura T, Ito N, Shibuya H, Hosoya T, Hagiwara M (2016) Selective inhibition of the kinase DYRK1A by targeting its folding process. Nat Commun 7:11391. https:\/\/doi.org\/10.1038\/ncomms11391","journal-title":"Nat Commun"},{"issue":"4","key":"3556_CR29","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1007\/s00018-015-2032-x","volume":"73","author":"AL Ashford","year":"2016","unstructured":"Ashford AL, Dunkley TPJ, Cockerill M, Rowlinson RA, Baak LM, Gallo R, Balmanno K, Goodwin LM, Ward RA, Lochhead PA, Guichard S, Hudson K, Cook SJ (2016) Identification of DYRK1B as a substrate of ERK1\/2 and characterisation of the kinase activity of DYRK1B mutants from cancer and metabolic syndrome. Cell Mol Life Sci 73(4):883\u2013900. https:\/\/doi.org\/10.1007\/s00018-015-2032-x","journal-title":"Cell Mol Life Sci"},{"issue":"10","key":"3556_CR30","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1016\/j.jmb.2018.04.001","volume":"430","author":"K Kim","year":"2018","unstructured":"Kim K, Cha JS, Cho Y-S, Kim H, Chang N, Kim H-J, Cho H-S (2018) Crystal structure of human dual-specificity tyrosine-regulated kinase 3 reveals new structural features and insights into its auto-phosphorylation. J Mol Biol 430(10):1521\u20131530. https:\/\/doi.org\/10.1016\/j.jmb.2018.04.001","journal-title":"J Mol Biol"},{"issue":"4","key":"3556_CR31","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1091\/mbc.e06-08-0668","volume":"18","author":"M Alvarez","year":"2007","unstructured":"Alvarez M, Altafaj X, Aranda S, de la Luna S (2007) DYRK1A autophosphorylation on serine residue 520 modulates its kinase activity via 14\u20133-3 binding. Mol Biol Cell 18(4):1167\u20131178. https:\/\/doi.org\/10.1091\/mbc.e06-08-0668","journal-title":"Mol Biol Cell"},{"issue":"5","key":"3556_CR32","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1016\/j.molcel.2007.02.007","volume":"25","author":"N Taira","year":"2007","unstructured":"Taira N, Nihira K, Yamaguchi T, Miki Y, Yoshida K (2007) DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage. Mol Cell 25(5):725\u2013738. https:\/\/doi.org\/10.1016\/j.molcel.2007.02.007","journal-title":"Mol Cell"},{"issue":"5","key":"3556_CR33","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1093\/jmcb\/mjs047","volume":"4","author":"M P\u00e9rez","year":"2012","unstructured":"P\u00e9rez M, Garc\u00eda-Limones C, Zapico I, Marina A, Schmitz ML, Mu\u00f1oz E, Calzado MA (2012) Mutual regulation between SIAH2 and DYRK2 controls hypoxic and genotoxic signaling pathways. J Mol Cell Biol 4(5):316\u2013330. https:\/\/doi.org\/10.1093\/jmcb\/mjs047","journal-title":"J Mol Cell Biol"},{"issue":"3","key":"3556_CR34","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/j.cell.2008.02.047","volume":"133","author":"M Varjosalo","year":"2008","unstructured":"Varjosalo M, Bjorklund M, Cheng F, Syvanen H, Kivioja T, Kilpinen S, Sun Z, Kallioniemi O, Stunnenberg HG, He WW, Ojala P, Taipale J (2008) Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling. Cell 133(3):537\u2013548. https:\/\/doi.org\/10.1016\/j.cell.2008.02.047","journal-title":"Cell"},{"key":"3556_CR35","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1016\/j.ijbiomac.2017.11.095","volume":"109","author":"L Xu","year":"2018","unstructured":"Xu L, Sun Y, Li M, Ge X (2018) Dyrk2 mediated the release of proinflammatory cytokines in LPS-induced BV2 cells. Int J Biol Macromol 109:1115\u20131124. https:\/\/doi.org\/10.1016\/j.ijbiomac.2017.11.095","journal-title":"Int J Biol Macromol"},{"issue":"4","key":"3556_CR36","doi-asserted-by":"publisher","first-page":"632","DOI":"10.15252\/embr.201642377","volume":"18","author":"D Hossain","year":"2017","unstructured":"Hossain D, Javadi Esfehani Y, Das A, Tsang WY (2017) Cep78 controls centrosome homeostasis by inhibiting EDD-DYRK2-DDB1. EMBO Rep 18(4):632\u2013644. https:\/\/doi.org\/10.15252\/embr.201642377","journal-title":"EMBO Rep"},{"key":"3556_CR37","doi-asserted-by":"publisher","first-page":"D512","DOI":"10.1093\/nar\/gku1267","volume":"43","author":"PV Hornbeck","year":"2015","unstructured":"Hornbeck PV, Zhang B, Murray B, Kornhauser JM, Latham V, Skrzypek E (2015) PhosphoSitePlus, 2014: mutations, PTMs and recalibrations. Nucleic Acids Res 43:D512\u2013520. https:\/\/doi.org\/10.1093\/nar\/gku1267","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"3556_CR38","doi-asserted-by":"publisher","first-page":"D542","DOI":"10.1093\/nar\/gkx1104","volume":"46","author":"H Huang","year":"2018","unstructured":"Huang H, Arighi CN, Ross KE, Ren J, Li G, Chen SC, Wang Q, Cowart J, Vijay-Shanker K, Wu CH (2018) iPTMnet: an integrated resource for protein post-translational modification network discovery. Nucleic Acids Res 46(D1):D542\u2013D550. https:\/\/doi.org\/10.1093\/nar\/gkx1104","journal-title":"Nucleic Acids Res"},{"issue":"1\u20132","key":"3556_CR39","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/s0014-5793(01)03221-5","volume":"510","author":"LE Campbell","year":"2002","unstructured":"Campbell LE, Proud CG (2002) Differing substrate specificities of members of the DYRK family of arginine-directed protein kinases. FEBS Lett 510(1\u20132):31\u201336. https:\/\/doi.org\/10.1016\/s0014-5793(01)03221-5","journal-title":"FEBS Lett"},{"key":"3556_CR40","doi-asserted-by":"publisher","DOI":"10.3390\/jdb5040013","author":"R Singh","year":"2017","unstructured":"Singh R, Lauth M (2017) Emerging roles of DYRK kinases in embryogenesis and hedgehog pathway control. J Dev Biol. https:\/\/doi.org\/10.3390\/jdb5040013","journal-title":"J Dev Biol"},{"issue":"2","key":"3556_CR41","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.ydbio.2012.07.032","volume":"370","author":"H Tanaka","year":"2012","unstructured":"Tanaka H, Morimura R, Ohshima T (2012) Dpysl2 (CRMP2) and Dpysl3 (CRMP4) phosphorylation by Cdk5 and DYRK2 is required for proper positioning of rohon-beard neurons and neural crest cells during neurulation in zebrafish. Dev Biol 370(2):223\u2013236. https:\/\/doi.org\/10.1016\/j.ydbio.2012.07.032","journal-title":"Dev Biol"},{"issue":"1","key":"3556_CR42","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.ydbio.2005.09.053","volume":"288","author":"Y Nishi","year":"2005","unstructured":"Nishi Y, Lin R (2005) DYRK2 and GSK-3 phosphorylate and promote the timely degradation of OMA-1, a key regulator of the oocyte-to-embryo transition in C. elegans. Dev Biol 288(1):139\u2013149. https:\/\/doi.org\/10.1016\/j.ydbio.2005.09.053","journal-title":"Dev Biol"},{"issue":"2","key":"3556_CR43","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.canlet.2013.06.005","volume":"339","author":"R Mimoto","year":"2013","unstructured":"Mimoto R, Taira N, Takahashi H, Yamaguchi T, Okabe M, Uchida K, Miki Y, Yoshida K (2013) DYRK2 controls the epithelial-mesenchymal transition in breast cancer by degrading Snail. Cancer Lett 339(2):214\u2013225. https:\/\/doi.org\/10.1016\/j.canlet.2013.06.005","journal-title":"Cancer Lett"},{"issue":"3","key":"3556_CR44","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1172\/JCI60818","volume":"122","author":"N Taira","year":"2012","unstructured":"Taira N, Mimoto R, Kurata M, Yamaguchi T, Kitagawa M, Miki Y, Yoshida K (2012) DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells. J Clin Investig 122(3):859\u2013872. https:\/\/doi.org\/10.1172\/JCI60818","journal-title":"J Clin Investig"},{"issue":"Pt 3","key":"3556_CR45","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1042\/bj3550609","volume":"355","author":"YL Woods","year":"2001","unstructured":"Woods YL, Cohen P, Becker W, Jakes R, Goedert M, Wang X, Proud CG (2001) The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase. Biochem J 355(Pt 3):609\u2013615. https:\/\/doi.org\/10.1042\/bj3550609","journal-title":"Biochem J"},{"issue":"24","key":"3556_CR46","doi-asserted-by":"publisher","first-page":"16591","DOI":"10.1074\/jbc.M513344200","volume":"281","author":"AR Cole","year":"2006","unstructured":"Cole AR, Causeret F, Yadirgi G, Hastie CJ, McLauchlan H, McManus EJ, Hernandez F, Eickholt BJ, Nikolic M, Sutherland C (2006) Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivo. J Biol Chem 281(24):16591\u201316598. https:\/\/doi.org\/10.1074\/jbc.M513344200","journal-title":"J Biol Chem"},{"key":"3556_CR47","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.pharmthera.2014.11.016","volume":"148","author":"E Beurel","year":"2015","unstructured":"Beurel E, Grieco SF, Jope RS (2015) Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases. Pharmacol Ther 148:114\u2013131. https:\/\/doi.org\/10.1016\/j.pharmthera.2014.11.016","journal-title":"Pharmacol Ther"},{"issue":"2","key":"3556_CR48","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.tibs.2003.12.004","volume":"29","author":"RS Jope","year":"2004","unstructured":"Jope RS, Johnson GV (2004) The glamour and gloom of glycogen synthase kinase-3. Trends Biochem Sci 29(2):95\u2013102. https:\/\/doi.org\/10.1016\/j.tibs.2003.12.004","journal-title":"Trends Biochem Sci"},{"issue":"Pt 7","key":"3556_CR49","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1242\/jcs.00384","volume":"116","author":"BW Doble","year":"2003","unstructured":"Doble BW, Woodgett JR (2003) GSK-3: tricks of the trade for a multi-tasking kinase. J Cell Sci 116(Pt 7):1175\u20131186. https:\/\/doi.org\/10.1242\/jcs.00384","journal-title":"J Cell Sci"},{"issue":"2","key":"3556_CR50","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/s0014-5793(99)01161-8","volume":"458","author":"GM Thomas","year":"1999","unstructured":"Thomas GM, Frame S, Goedert M, Nathke I, Polakis P, Cohen P (1999) A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of axin and beta-catenin. FEBS Lett 458(2):247\u2013251. https:\/\/doi.org\/10.1016\/s0014-5793(99)01161-8","journal-title":"FEBS Lett"},{"issue":"4","key":"3556_CR51","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1038\/ncb1848","volume":"11","author":"S Maddika","year":"2009","unstructured":"Maddika S, Chen J (2009) Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase. Nat Cell Biol 11(4):409\u2013419. https:\/\/doi.org\/10.1038\/ncb1848","journal-title":"Nat Cell Biol"},{"issue":"10","key":"3556_CR52","doi-asserted-by":"publisher","first-page":"7252","DOI":"10.1074\/jbc.M112.416792","volume":"288","author":"H-Y Jung","year":"2013","unstructured":"Jung H-Y, Wang X, Jun S, Park J-I (2013) Dyrk2-associated EDD-DDB1-VprBP E3 ligase inhibits telomerase by TERT degradation. J Biol Chem 288(10):7252\u20137262. https:\/\/doi.org\/10.1074\/jbc.M112.416792","journal-title":"J Biol Chem"},{"issue":"5","key":"3556_CR53","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1002\/em.22087","volume":"58","author":"N Chatterjee","year":"2017","unstructured":"Chatterjee N, Walker GC (2017) Mechanisms of DNA damage, repair, and mutagenesis. Environ Mol Mutagen 58(5):235\u2013263. https:\/\/doi.org\/10.1002\/em.22087","journal-title":"Environ Mol Mutagen"},{"issue":"11","key":"3556_CR54","doi-asserted-by":"publisher","first-page":"3376","DOI":"10.1111\/cas.13792","volume":"109","author":"S Yogosawa","year":"2018","unstructured":"Yogosawa S, Yoshida K (2018) Tumor suppressive role for kinases phosphorylating p53 in DNA damage-induced apoptosis. Cancer Sci 109(11):3376\u20133382. https:\/\/doi.org\/10.1111\/cas.13792","journal-title":"Cancer Sci"},{"issue":"6","key":"3556_CR55","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1002\/1873-3468.12596","volume":"591","author":"T Yamamoto","year":"2017","unstructured":"Yamamoto T, Taira Nihira N, Yogosawa S, Aoki K, Takeda H, Sawasaki T, Yoshida K (2017) Interaction between RNF8 and DYRK2 is required for the recruitment of DNA repair molecules to DNA double-strand breaks. FEBS Lett 591(6):842\u2013853. https:\/\/doi.org\/10.1002\/1873-3468.12596","journal-title":"FEBS Lett"},{"issue":"10","key":"3556_CR56","doi-asserted-by":"publisher","first-page":"e76775","DOI":"10.1371\/journal.pone.0076775","volume":"8","author":"N Luebbering","year":"2013","unstructured":"Luebbering N, Charlton-Perkins M, Kumar JP, Rollmann SM, Cook T, Cleghon V (2013) Drosophila Dyrk2 plays a role in the development of the visual system. PLoS ONE 8(10):e76775. https:\/\/doi.org\/10.1371\/journal.pone.0076775","journal-title":"PLoS ONE"},{"issue":"2","key":"3556_CR57","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1093\/genetics\/163.2.571","volume":"163","author":"WB Raich","year":"2003","unstructured":"Raich WB, Moorman C, Lacefield CO, Lehrer J, Bartsch D, Plasterk RHA, Kandel ER, Hobert O (2003) Characterization of Caenorhabditis elegans homologs of the down syndrome candidate gene DYRK1A. Genetics 163(2):571\u2013580","journal-title":"Genetics"},{"issue":"6\u20137","key":"3556_CR58","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1387\/ijdb.160175sj","volume":"61","author":"W Sun","year":"2017","unstructured":"Sun W, Jiao S, Tan X, Zhang P, You F (2017) DYRK2 displays muscle fiber type specific function during zebrafish early somitogenesis. Int J Dev Biol 61(6\u20137):459\u2013463. https:\/\/doi.org\/10.1387\/ijdb.160175sj","journal-title":"Int J Dev Biol"},{"key":"3556_CR59","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.50850","author":"Y Woo","year":"2019","unstructured":"Woo Y, Kim SJ, Suh BK (2019) Sequential phosphorylation of NDEL1 by the DYRK2-GSK3beta complex is critical for neuronal morphogenesis. Elife. https:\/\/doi.org\/10.7554\/eLife.50850","journal-title":"Elife"},{"key":"3556_CR60","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.51620","author":"M Cayla","year":"2020","unstructured":"Cayla M, McDonald L, MacGregor P, Matthews K (2020) An atypical DYRK kinase connects quorum-sensing with posttranscriptional gene regulation in Trypanosoma brucei. Elife. https:\/\/doi.org\/10.7554\/eLife.51620","journal-title":"Elife"},{"issue":"7093","key":"3556_CR61","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1038\/nature04631","volume":"441","author":"Y Gwack","year":"2006","unstructured":"Gwack Y, Sharma S, Nardone J, Tanasa B, Iuga A, Srikanth S, Okamura H, Bolton D, Feske S, Hogan PG, Rao A (2006) A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT. Nature 441(7093):646\u2013650. https:\/\/doi.org\/10.1038\/nature04631","journal-title":"Nature"},{"key":"3556_CR62","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-019-03309-9","author":"R Morrugares","year":"2019","unstructured":"Morrugares R, Correa-S\u00e1ez A, Moreno R, Garrido-Rodr\u00edguez M, Mu\u00f1oz E, de la Vega L, Calzado MA (2019) Phosphorylation-dependent regulation of the NOTCH1 intracellular domain by dual-specificity tyrosine-regulated kinase 2. Cell Mol Life Sci. https:\/\/doi.org\/10.1007\/s00018-019-03309-9","journal-title":"Cell Mol Life Sci"},{"issue":"9","key":"3556_CR63","doi-asserted-by":"publisher","first-page":"e1005179","DOI":"10.1371\/journal.ppat.1005179","volume":"11","author":"T An","year":"2015","unstructured":"An T, Li S, Pan W, Tien P, Zhong B, Shu HB, Wu S (2015) DYRK2 negatively regulates type I interferon induction by promoting TBK1 degradation via Ser527 phosphorylation. PLoS Pathog 11(9):e1005179. https:\/\/doi.org\/10.1371\/journal.ppat.1005179","journal-title":"PLoS Pathog"},{"key":"3556_CR64","doi-asserted-by":"crossref","unstructured":"Moreno R, Banerjee S, Jackson AW, Quinn J, Baillie G, Dixon JE, Dinkova-Kostova AT, Edwards J, de la Vega L (2019) DYRK2 activates heat shock factor 1 promoting resistance to proteotoxic stress in triplenegative breast cancer. bioRxiv","DOI":"10.1101\/633560"},{"issue":"2","key":"3556_CR65","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1111\/cas.13459","volume":"109","author":"Y Imawari","year":"2018","unstructured":"Imawari Y, Mimoto R, Hirooka S, Morikawa T, Takeyama H, Yoshida K (2018) Downregulation of dual-specificity tyrosine-regulated kinase 2 promotes tumor cell proliferation and invasion by enhancing cyclin-dependent kinase 14 expression in breast cancer. Cancer Sci 109(2):363\u2013372. https:\/\/doi.org\/10.1111\/cas.13459","journal-title":"Cancer Sci"},{"issue":"2","key":"3556_CR66","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1038\/ncb3289","volume":"18","author":"X Guo","year":"2016","unstructured":"Guo X, Wang X, Wang Z, Banerjee S, Yang J, Huang L, Dixon JE (2016) Site-specific proteasome phosphorylation controls cell proliferation and tumorigenesis. Nat Cell Biol 18(2):202\u2013212. https:\/\/doi.org\/10.1038\/ncb3289","journal-title":"Nat Cell Biol"},{"issue":"1","key":"3556_CR67","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1042\/bj20130558","volume":"459","author":"SS Ong","year":"2014","unstructured":"Ong SS, Goktug AN, Elias A, Wu J, Saunders D, Chen T (2014) Stability of the human pregnane X receptor is regulated by E3 ligase UBR5 and serine\/threonine kinase DYRK2. Biochem J 459(1):193\u2013203. https:\/\/doi.org\/10.1042\/bj20130558","journal-title":"Biochem J"},{"issue":"9","key":"3556_CR68","doi-asserted-by":"publisher","first-page":"e70848","DOI":"10.1371\/journal.pone.0070848","volume":"8","author":"CS Weiss","year":"2013","unstructured":"Weiss CS, Ochs MM, Hagenmueller M, Streit MR, Malekar P, Riffel JH, Buss SJ, Weiss KH, Sadoshima J, Katus HA, Hardt SE (2013) DYRK2 negatively regulates cardiomyocyte growth by mediating repressor function of GSK-3beta on eIF2Bepsilon. PLoS ONE 8(9):e70848. https:\/\/doi.org\/10.1371\/journal.pone.0070848","journal-title":"PLoS ONE"},{"issue":"14","key":"3556_CR69","first-page":"4136","volume":"63","author":"CT Miller","year":"2003","unstructured":"Miller CT, Aggarwal S, Lin TK, Dagenais SL, Contreras JI, Orringer MB, Glover TW, Beer DG, Lin L (2003) Amplification and overexpression of the dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 (DYRK2) gene in esophageal and lung adenocarcinomas. Can Res 63(14):4136\u20134143","journal-title":"Can Res"},{"issue":"11","key":"3556_CR70","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1007\/s11064-017-2345-2","volume":"1","author":"Y Shen","year":"2017","unstructured":"Shen Y, Zhang L, Wang D, Bao Y, Liu C, Xu Z, Huang W, Cheng C (2017) Regulation of glioma cells migration by DYRK2. Neurochem Res 1(11):910\u2013935. https:\/\/doi.org\/10.1007\/s11064-017-2345-2","journal-title":"Neurochem Res"},{"issue":"18","key":"3556_CR71","doi-asserted-by":"publisher","first-page":"3389","DOI":"10.4161\/cc.21404","volume":"11","author":"W Becker","year":"2012","unstructured":"Becker W (2012) Emerging role of DYRK family protein kinases as regulators of protein stability in cell cycle control. Cell Cycle (Georgetown, Tex) 11(18):3389\u20133394. https:\/\/doi.org\/10.4161\/cc.21404","journal-title":"Cell Cycle (Georgetown, Tex)"},{"issue":"1","key":"3556_CR72","doi-asserted-by":"publisher","first-page":"e87409","DOI":"10.1371\/journal.pone.0087409","volume":"9","author":"W Zhou","year":"2014","unstructured":"Zhou W, Lv R, Qi W, Wu D, Xu Y, Liu W, Mou Y, Wang L (2014) Snail contributes to the maintenance of stem cell-like phenotype cells in human pancreatic cancer. PLoS ONE 9(1):e87409. https:\/\/doi.org\/10.1371\/journal.pone.0087409","journal-title":"PLoS ONE"},{"key":"3556_CR73","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-19-0049","author":"K-J Ryu","year":"2019","unstructured":"Ryu K-J, Park S-M, Park S-H, Kim I-K, Han H-T, Kim H-J, Kim SH, Hong K-S, Kim H, Kim M, Yoon S-J, Asaithambi K, Lee KH, Park J-Y, Hah Y-S, Cho HJ, Yook JI, Yang JW, Ko G-H, Lee G, Kang YJ, Hwangbo C, Kim KD, Park Y-J, Yoo J (2019) p38 stabilizes snail by suppressing DYRK2-mediated phosphorylation that is required for GSK3\u03b2-\u03b2TrCP-induced snail degradation. Cancer Res. https:\/\/doi.org\/10.1158\/0008-5472.CAN-19-0049","journal-title":"Cancer Res"},{"issue":"8","key":"3556_CR74","doi-asserted-by":"publisher","first-page":"5913","DOI":"10.1007\/s13277-015-3264-y","volume":"36","author":"N Yamaguchi","year":"2015","unstructured":"Yamaguchi N, Mimoto R, Yanaihara N, Imawari Y, Hirooka S, Okamoto A, Yoshida K (2015) DYRK2 regulates epithelial-mesenchymal-transition and chemosensitivity through Snail degradation in ovarian serous adenocarcinoma. Tumour Biol 36(8):5913\u20135923. https:\/\/doi.org\/10.1007\/s13277-015-3264-y","journal-title":"Tumour Biol"},{"issue":"83","key":"3556_CR75","first-page":"221","volume":"15","author":"MM Mrugala","year":"2013","unstructured":"Mrugala MM (2013) Advances and challenges in the treatment of glioblastoma: a clinician's perspective. Discov Med 15(83):221\u2013230","journal-title":"Discov Med"},{"issue":"8","key":"3556_CR76","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1111\/cas.13280","volume":"108","author":"D Ito","year":"2017","unstructured":"Ito D, Yogosawa S, Mimoto R, Hirooka S, Horiuchi T, Eto K, Yanaga K, Yoshida K (2017) Dual-specificity tyrosine-regulated kinase 2 is a suppressor and potential prognostic marker for liver metastasis of colorectal cancer. Cancer Sci 108(8):1565\u20131573. https:\/\/doi.org\/10.1111\/cas.13280","journal-title":"Cancer Sci"},{"issue":"8","key":"3556_CR77","doi-asserted-by":"publisher","first-page":"e0159954","DOI":"10.1371\/journal.pone.0159954","volume":"11","author":"H Yan","year":"2016","unstructured":"Yan H, Hu K, Wu W, Li Y, Tian H, Chu Z, Koeffler HP, Yin D (2016) Low expression of DYRK2 (dual specificity tyrosine phosphorylation regulated kinase 2) correlates with poor prognosis in colorectal cancer. PLoS ONE 11(8):e0159954\u2013e1159918. https:\/\/doi.org\/10.1371\/journal.pone.0159954","journal-title":"PLoS ONE"},{"issue":"13","key":"3556_CR78","doi-asserted-by":"publisher","first-page":"1862","DOI":"10.1038\/onc.2016.349","volume":"36","author":"R Mimoto","year":"2017","unstructured":"Mimoto R, Imawari Y, Hirooka S, Takeyama H, Yoshida K (2017) Impairment of DYRK2 augments stem-like traits by promoting KLF4 expression in breast cancer. Oncogene 36(13):1862\u20131872. https:\/\/doi.org\/10.1038\/onc.2016.349","journal-title":"Oncogene"},{"issue":"21","key":"3556_CR79","doi-asserted-by":"publisher","first-page":"2953","DOI":"10.1002\/1873-3468.13601","volume":"593","author":"S Yoshida","year":"2019","unstructured":"Yoshida S, Yoshida K (2019) Multiple functions of DYRK2 in cancer and tissue development. FEBS Lett 593(21):2953\u20132965. https:\/\/doi.org\/10.1002\/1873-3468.13601","journal-title":"FEBS Lett"},{"key":"3556_CR80","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2016.01.002","author":"X Zhang","year":"2016","unstructured":"Zhang X, Xu P, Ni W, Fan H, Xu J, Chen Y, Huang W, Lu S, Liang L, Liu J, Chen B, Shi W (2016) Downregulated DYRK2 expression is associated with poor prognosis and oxaliplatin resistance in hepatocellular carcinoma. Pathol Res Pract. https:\/\/doi.org\/10.1016\/j.prp.2016.01.002","journal-title":"Pathol Res Pract"},{"issue":"7","key":"3556_CR81","first-page":"2753","volume":"29","author":"S Yamashita","year":"2009","unstructured":"Yamashita S, Chujo M, Moroga T, Anami K, Tokuishi K, Miyawaki M, Kawano Y, Takeno S, Yamamoto S, Kawahara K (2009) DYRK2 expression may be a predictive marker for chemotherapy in non-small cell lung cancer. Anticancer Res 29(7):2753\u20132757","journal-title":"Anticancer Res"},{"issue":"6","key":"3556_CR82","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1016\/j.jtcvs.2009.08.003","volume":"138","author":"S Yamashita","year":"2009","unstructured":"Yamashita S, Chujo M, Tokuishi K, Anami K, Miyawaki M, Yamamoto S, Kawahara K (2009) Expression of dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 2 (DYRK2) can be a favorable prognostic marker in pulmonary adenocarcinoma. J Thorac Cardiovasc Surg 138(6):1303\u20131308. https:\/\/doi.org\/10.1016\/j.jtcvs.2009.08.003","journal-title":"J Thorac Cardiovasc Surg"},{"key":"3556_CR83","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/s12894-015-0040-7","volume":"15","author":"S Nomura","year":"2015","unstructured":"Nomura S, Suzuki Y, Takahashi R, Terasaki M, Kimata R, Terasaki Y, Hamasaki T, Kimura G, Shimizu A, Kondo Y (2015) Dual-specificity tyrosine phosphorylation-regulated kinase 2 (DYRK2) as a novel marker in T1 high-grade and T2 bladder cancer patients receiving neoadjuvant chemotherapy. BMC Urol 15:53. https:\/\/doi.org\/10.1186\/s12894-015-0040-7","journal-title":"BMC Urol"},{"key":"3556_CR84","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1016\/j.ijbiomac.2015.08.067","volume":"81","author":"Y Wang","year":"2015","unstructured":"Wang Y, Wu Y, Miao X, Zhu X, Miao X, He Y, Zhong F, Ding L, Liu J, Tang J, Huang Y, Xu X, He S (2015) Silencing of DYRK2 increases cell proliferation but reverses CAM-DR in Non-Hodgkin's Lymphoma. Int J Biol Macromol 81:809\u2013817. https:\/\/doi.org\/10.1016\/j.ijbiomac.2015.08.067","journal-title":"Int J Biol Macromol"},{"key":"3556_CR85","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1186\/s12935-018-0574-3","volume":"18","author":"KL Uhl","year":"2018","unstructured":"Uhl KL, Schultz CR, Geerts D, Bachmann AS (2018) Harmine, a dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor induces caspase-mediated apoptosis in neuroblastoma. Cancer Cell Int 18:82. https:\/\/doi.org\/10.1186\/s12935-018-0574-3","journal-title":"Cancer Cell Int"},{"issue":"11","key":"3556_CR86","doi-asserted-by":"publisher","first-page":"11021","DOI":"10.1007\/s13277-014-2413-z","volume":"35","author":"Y Enomoto","year":"2014","unstructured":"Enomoto Y, Yamashita S, Yoshinaga Y, Fukami Y, Miyahara S, Nabeshima K, Iwasaki A (2014) Downregulation of DYRK2 can be a predictor of recurrence in early stage breast cancer. Tumour Biol 35(11):11021\u201311025. https:\/\/doi.org\/10.1007\/s13277-014-2413-z","journal-title":"Tumour Biol"},{"issue":"Pt A","key":"3556_CR87","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1016\/j.ijbiomac.2017.06.087","volume":"104","author":"Y Sun","year":"2017","unstructured":"Sun Y, Ge X, Li M, Xu L, Shen Y (2017) Dyrk2 involved in regulating LPS-induced neuronal apoptosis. Int J Biol Macromol 104(Pt A):979\u2013986. https:\/\/doi.org\/10.1016\/j.ijbiomac.2017.06.087","journal-title":"Int J Biol Macromol"},{"issue":"14","key":"3556_CR88","doi-asserted-by":"publisher","first-page":"199","DOI":"10.4103\/0973-7847.120524","volume":"7","author":"M Moloudizargari","year":"2013","unstructured":"Moloudizargari M, Mikaili P, Aghajanshakeri S, Asghari MH, Shayegh J (2013) Pharmacological and therapeutic effects of Peganum harmala and its main alkaloids. Pharmacogn Rev 7(14):199\u2013212. https:\/\/doi.org\/10.4103\/0973-7847.120524","journal-title":"Pharmacogn Rev"},{"issue":"11","key":"3556_CR89","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1080\/15384047.2015.1078021","volume":"16","author":"L Zhang","year":"2015","unstructured":"Zhang L, Zhang F, Zhang W, Chen L, Gao N, Men Y, Xu X, Jiang Y (2015) Harmine suppresses homologous recombination repair and inhibits proliferation of hepatoma cells. Cancer Biol Ther 16(11):1585\u20131592. https:\/\/doi.org\/10.1080\/15384047.2015.1078021","journal-title":"Cancer Biol Ther"},{"issue":"21","key":"3556_CR90","doi-asserted-by":"publisher","first-page":"6324","DOI":"10.1111\/j.1742-4658.2009.07346.x","volume":"276","author":"N Gockler","year":"2009","unstructured":"Gockler N, Jofre G, Papadopoulos C, Soppa U, Tejedor FJ, Becker W (2009) Harmine specifically inhibits protein kinase DYRK1A and interferes with neurite formation. FEBS J 276(21):6324\u20136337. https:\/\/doi.org\/10.1111\/j.1742-4658.2009.07346.x","journal-title":"FEBS J"},{"key":"3556_CR91","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1038\/ncomms1090","volume":"1","author":"Y Ogawa","year":"2010","unstructured":"Ogawa Y, Nonaka Y, Goto T, Ohnishi E, Hiramatsu T, Kii I, Yoshida M, Ikura T, Onogi H, Shibuya H, Hosoya T, Ito N, Hagiwara M (2010) Development of a novel selective inhibitor of the down syndrome-related kinase Dyrk1A. Nat Commun 1:86. https:\/\/doi.org\/10.1038\/ncomms1090","journal-title":"Nat Commun"},{"issue":"1","key":"3556_CR92","doi-asserted-by":"publisher","first-page":"26","DOI":"10.2174\/18715273113126660186","volume":"13","author":"W Becker","year":"2014","unstructured":"Becker W, Soppa U, Tejedor FJ (2014) DYRK1A: a potential drug target for multiple down syndrome neuropathologies. CNS Neurol Disord Drug Targets 13(1):26\u201333. https:\/\/doi.org\/10.2174\/18715273113126660186","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"3556_CR93","doi-asserted-by":"publisher","first-page":"16078","DOI":"10.1038\/nrdp.2016.78","volume":"2","author":"KK Matthay","year":"2016","unstructured":"Matthay KK, Maris JM, Schleiermacher G, Nakagawara A, Mackall CL, Diller L, Weiss WA (2016) Neuroblastoma. Nat Rev Dis Primers 2:16078. https:\/\/doi.org\/10.1038\/nrdp.2016.78","journal-title":"Nat Rev Dis Primers"},{"issue":"5","key":"3556_CR94","doi-asserted-by":"publisher","first-page":"1620","DOI":"10.1021\/acs.jmedchem.6b00975","volume":"60","author":"KM Nelson","year":"2017","unstructured":"Nelson KM, Dahlin JL, Bisson J, Graham J, Pauli GF, Walters MA (2017) The essential medicinal chemistry of curcumin. J Med Chem 60(5):1620\u20131637. https:\/\/doi.org\/10.1021\/acs.jmedchem.6b00975","journal-title":"J Med Chem"},{"issue":"12","key":"3556_CR95","doi-asserted-by":"publisher","first-page":"3491","DOI":"10.1016\/j.bmcl.2010.04.150","volume":"20","author":"GD Cuny","year":"2010","unstructured":"Cuny GD, Robin M, Ulyanova NP, Patnaik D, Pique V, Casano G, Liu JF, Lin X, Xian J, Glicksman MA, Stein RL, Higgins JM (2010) Structure-activity relationship study of acridine analogs as haspin and DYRK2 kinase inhibitors. Bioorg Med Chem Lett 20(12):3491\u20133494","journal-title":"Bioorg Med Chem Lett"},{"issue":"5","key":"3556_CR96","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1016\/j.bmcl.2012.01.028","volume":"22","author":"GD Cuny","year":"2012","unstructured":"Cuny GD, Ulyanova NP, Patnaik D, Liu JF, Lin X, Auerbach K, Ray SS, Xian J, Glicksman MA, Stein RL, Higgins JM (2012) Structure-activity relationship study of beta-carboline derivatives as haspin kinase inhibitors. Bioorg Med Chem Lett 22(5):2015\u20132019. https:\/\/doi.org\/10.1016\/j.bmcl.2012.01.028","journal-title":"Bioorg Med Chem Lett"},{"issue":"5","key":"3556_CR97","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1271\/bbb.70717","volume":"72","author":"T Miyabayashi","year":"2008","unstructured":"Miyabayashi T, Yamamoto M, Sato A, Sakano S, Takahashi Y (2008) Indole derivatives sustain embryonic stem cell self-renewal in long-term culture. Biosci Biotechnol Biochem 72(5):1242\u20131248. https:\/\/doi.org\/10.1271\/bbb.70717","journal-title":"Biosci Biotechnol Biochem"},{"issue":"1","key":"3556_CR98","doi-asserted-by":"publisher","first-page":"18","DOI":"10.5966\/sctm.2011-0033","volume":"1","author":"K Hasegawa","year":"2012","unstructured":"Hasegawa K, Yasuda SY, Teo JL, Nguyen C, McMillan M, Hsieh CL, Suemori H, Nakatsuji N, Yamamoto M, Miyabayashi T, Lutzko C, Pera MF, Kahn M (2012) Wnt signaling orchestration with a small molecule DYRK inhibitor provides long-term xeno-free human pluripotent cell expansion. Stem Cells Transl Med 1(1):18\u201328. https:\/\/doi.org\/10.5966\/sctm.2011-0033","journal-title":"Stem Cells Transl Med"},{"issue":"47","key":"3556_CR99","doi-asserted-by":"publisher","first-page":"6304","DOI":"10.1038\/sj.onc.1209648","volume":"25","author":"J Ribas","year":"2006","unstructured":"Ribas J, Bettayeb K, Ferandin Y, Knockaert M, Garrofe-Ochoa X, Totzke F, Schachtele C, Mester J, Polychronopoulos P, Magiatis P, Skaltsounis AL, Boix J, Meijer L (2006) 7-Bromoindirubin-3'-oxime induces caspase-independent cell death. Oncogene 25(47):6304\u20136318. https:\/\/doi.org\/10.1038\/sj.onc.1209648","journal-title":"Oncogene"},{"issue":"1","key":"3556_CR100","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1021\/ml300207a","volume":"4","author":"V Myrianthopoulos","year":"2013","unstructured":"Myrianthopoulos V, Kritsanida M, Gaboriaud-Kolar N, Magiatis P, Ferandin Y, Durieu E, Lozach O, Cappel D, Soundararajan M, Filippakopoulos P, Sherman W, Knapp S, Meijer L, Mikros E, Skaltsounis AL (2013) Novel inverse binding mode of indirubin derivatives yields improved selectivity for DYRK kinases. ACS Med Chem Lett 4(1):22\u201326. https:\/\/doi.org\/10.1021\/ml300207a","journal-title":"ACS Med Chem Lett"},{"issue":"17","key":"3556_CR101","doi-asserted-by":"publisher","first-page":"4027","DOI":"10.1021\/jm070077z","volume":"50","author":"V Myrianthopoulos","year":"2007","unstructured":"Myrianthopoulos V, Magiatis P, Ferandin Y, Skaltsounis AL, Meijer L, Mikros E (2007) An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins. J Med Chem 50(17):4027\u20134037. https:\/\/doi.org\/10.1021\/jm070077z","journal-title":"J Med Chem"},{"issue":"1","key":"3556_CR102","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1042\/BJ20130461","volume":"457","author":"AL Ashford","year":"2014","unstructured":"Ashford AL, Oxley D, Kettle J, Hudson K, Guichard S, Cook SJ, Lochhead PA (2014) A novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3beta to phosphorylate cyclin D1 at Thr(286), not Thr(288). Biochem J 457(1):43\u201356. https:\/\/doi.org\/10.1042\/BJ20130461","journal-title":"Biochem J"},{"issue":"6220","key":"3556_CR103","doi-asserted-by":"publisher","first-page":"1260419","DOI":"10.1126\/science.1260419","volume":"347","author":"M Uhlen","year":"2015","unstructured":"Uhlen M, Fagerberg L, Hallstrom BM, Lindskog C, Oksvold P, Mardinoglu A, Sivertsson A, Kampf C, Sjostedt E, Asplund A, Olsson I, Edlund K, Lundberg E, Navani S, Szigyarto CA, Odeberg J, Djureinovic D, Takanen JO, Hober S, Alm T, Edqvist PH, Berling H, Tegel H, Mulder J, Rockberg J, Nilsson P, Schwenk JM, Hamsten M, von Feilitzen K, Forsberg M, Persson L, Johansson F, Zwahlen M, von Heijne G, Nielsen J, Ponten F (2015) Proteomics. Tissue-based map of the human proteome. Science 347(6220):1260419. https:\/\/doi.org\/10.1126\/science.1260419","journal-title":"Science"},{"key":"3556_CR104","doi-asserted-by":"publisher","first-page":"D535","DOI":"10.1093\/nar\/gkj109","volume":"34","author":"C Stark","year":"2006","unstructured":"Stark C, Breitkreutz BJ, Reguly T, Boucher L, Breitkreutz A, Tyers M (2006) BioGRID: a general repository for interaction datasets. Nucleic Acids Res 34:D535\u2013539. https:\/\/doi.org\/10.1093\/nar\/gkj109","journal-title":"Nucleic Acids Res"},{"issue":"6","key":"3556_CR105","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","volume":"1","author":"A Liberzon","year":"2015","unstructured":"Liberzon A, Birger C, Thorvaldsdottir H, Ghandi M, Mesirov JP, Tamayo P (2015) The molecular signatures database (MSigDB) hallmark gene set collection. Cell Syst 1(6):417\u2013425. https:\/\/doi.org\/10.1016\/j.cels.2015.12.004","journal-title":"Cell Syst"},{"issue":"5","key":"3556_CR106","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","volume":"16","author":"G Yu","year":"2012","unstructured":"Yu G, Wang LG, Han Y, He QY (2012) clusterProfiler: an R package for comparing biological themes among gene clusters. OMICS 16(5):284\u2013287. https:\/\/doi.org\/10.1089\/omi.2011.0118","journal-title":"OMICS"},{"key":"3556_CR107","doi-asserted-by":"publisher","DOI":"10.1093\/database\/baw160","author":"M Deng","year":"2017","unstructured":"Deng M, Bragelmann J, Kryukov I, Saraiva-Agostinho N, Perner S (2017) FirebrowseR: an R client to the Broad Institute's firehose pipeline. Database (Oxford). https:\/\/doi.org\/10.1093\/database\/baw160","journal-title":"Database (Oxford)"},{"issue":"7391","key":"3556_CR108","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1038\/nature11003","volume":"483","author":"J Barretina","year":"2012","unstructured":"Barretina J, Caponigro G, Stransky N, Venkatesan K, Margolin AA, Kim S, Wilson CJ, Lehar J, Kryukov GV, Sonkin D, Reddy A, Liu M, Murray L, Berger MF, Monahan JE, Morais P, Meltzer J, Korejwa A, Jane-Valbuena J, Mapa FA, Thibault J, Bric-Furlong E, Raman P, Shipway A, Engels IH, Cheng J, Yu GK, Yu J, Aspesi P Jr, de Silva M, Jagtap K, Jones MD, Wang L, Hatton C, Palescandolo E, Gupta S, Mahan S, Sougnez C, Onofrio RC, Liefeld T, MacConaill L, Winckler W, Reich M, Li N, Mesirov JP, Gabriel SB, Getz G, Ardlie K, Chan V, Myer VE, Weber BL, Porter J, Warmuth M, Finan P, Harris JL, Meyerson M, Golub TR, Morrissey MP, Sellers WR, Schlegel R, Garraway LA (2012) The cancer cell line encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature 483(7391):603\u2013607. https:\/\/doi.org\/10.1038\/nature11003","journal-title":"Nature"},{"issue":"5","key":"3556_CR109","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1158\/2159-8290.CD-12-0095","volume":"2","author":"E Cerami","year":"2012","unstructured":"Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA, Jacobsen A, Byrne CJ, Heuer ML, Larsson E, Antipin Y, Reva B, Goldberg AP, Sander C, Schultz N (2012) The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov 2(5):401\u2013404. https:\/\/doi.org\/10.1158\/2159-8290.CD-12-0095","journal-title":"Cancer Discov"},{"issue":"Pt 3","key":"3556_CR110","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1042\/BJ20050733","volume":"389","author":"GC Auld","year":"2005","unstructured":"Auld GC, Campbell DG, Morrice N, Cohen P (2005) Identification of calcium-regulated heat-stable protein of 24 kDa (CRHSP24) as a physiological substrate for PKB and RSK using KESTREL. Biochem J 389(Pt 3):775\u2013783. https:\/\/doi.org\/10.1042\/BJ20050733","journal-title":"Biochem J"},{"issue":"48","key":"3556_CR111","doi-asserted-by":"publisher","first-page":"50176","DOI":"10.1074\/jbc.C400412200","volume":"279","author":"AR Cole","year":"2004","unstructured":"Cole AR, Knebel A, Morrice NA, Robertson LA, Irving AJ, Connolly CN, Sutherland C (2004) GSK-3 phosphorylation of the Alzheimer epitope within collapsin response mediator proteins regulates axon elongation in primary neurons. J Biol Chem 279(48):50176\u201350180. https:\/\/doi.org\/10.1074\/jbc.C400412200","journal-title":"J Biol Chem"},{"issue":"7","key":"3556_CR112","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1002\/cm.21021","volume":"69","author":"TI Slepak","year":"2012","unstructured":"Slepak TI, Salay LD, Lemmon VP, Bixby JL (2012) Dyrk kinases regulate phosphorylation of doublecortin, cytoskeletal organization, and neuronal morphology. Cytoskeleton (Hoboken) 69(7):514\u2013527. https:\/\/doi.org\/10.1002\/cm.21021","journal-title":"Cytoskeleton (Hoboken)"},{"issue":"5","key":"3556_CR113","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1128\/mcb.23.5.1546-1557.2003","volume":"23","author":"X Wang","year":"2003","unstructured":"Wang X, Li W, Parra JL, Beugnet A, Proud CG (2003) The C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylation. Mol Cell Biol 23(5):1546\u20131557. https:\/\/doi.org\/10.1128\/mcb.23.5.1546-1557.2003","journal-title":"Mol Cell Biol"},{"issue":"4","key":"3556_CR114","doi-asserted-by":"publisher","first-page":"2490","DOI":"10.1074\/jbc.M301769200","volume":"279","author":"AV Skurat","year":"2004","unstructured":"Skurat AV, Dietrich AD (2004) Phosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinases. J Biol Chem 279(4):2490\u20132498. https:\/\/doi.org\/10.1074\/jbc.M301769200","journal-title":"J Biol Chem"},{"key":"3556_CR115","doi-asserted-by":"publisher","first-page":"6622","DOI":"10.1038\/ncomms7622","volume":"6","author":"CF Tsai","year":"2015","unstructured":"Tsai CF, Wang YT, Yen HY, Tsou CC, Ku WC, Lin PY, Chen HY, Nesvizhskii AI, Ishihama Y, Chen YJ (2015) Large-scale determination of absolute phosphorylation stoichiometries in human cells by motif-targeting quantitative proteomics. Nat Commun 6:6622. https:\/\/doi.org\/10.1038\/ncomms7622","journal-title":"Nat Commun"},{"issue":"1\u20132","key":"3556_CR116","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/s0022-1759(00)00313-6","volume":"247","author":"R Matsuo","year":"2001","unstructured":"Matsuo R, Ochiai W, Nakashima K, Taga T (2001) A new expression cloning strategy for isolation of substrate-specific kinases by using phosphorylation site-specific antibody. J Immunol Methods 247(1\u20132):141\u2013151. https:\/\/doi.org\/10.1016\/s0022-1759(00)00313-6","journal-title":"J Immunol Methods"},{"issue":"7","key":"3556_CR117","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1016\/j.cell.2010.12.001","volume":"143","author":"EL Huttlin","year":"2010","unstructured":"Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143(7):1174\u20131189. https:\/\/doi.org\/10.1016\/j.cell.2010.12.001","journal-title":"Cell"},{"key":"3556_CR118","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.canlet.2019.02.046","volume":"451","author":"S Yokoyama-Mashima","year":"2019","unstructured":"Yokoyama-Mashima S, Yogosawa S, Kanegae Y, Hirooka S, Yoshida S, Horiuchi T, Ohashi T, Yanaga K, Saruta M, Oikawa T, Yoshida K (2019) Forced expression of DYRK2 exerts anti-tumor effects via apoptotic induction in liver cancer. Cancer Lett 451:100\u2013109. https:\/\/doi.org\/10.1016\/j.canlet.2019.02.046","journal-title":"Cancer Lett"},{"issue":"11","key":"3556_CR119","doi-asserted-by":"publisher","first-page":"e0143376","DOI":"10.1371\/journal.pone.0143376.s002","volume":"10","author":"P Moreno","year":"2015","unstructured":"Moreno P, Lara-Chica M, Soler-Torronteras R, Caro T, Medina M, \u00c1lvarez A, Salvatierra \u00c1, Munoz E, Calzado Canale MA (2015) The expression of the ubiquitin ligase SIAH2 (seven in Absentia Homolog 2) is increased in human lung cancer. PLoS ONE 10(11):e0143376. https:\/\/doi.org\/10.1371\/journal.pone.0143376.s002","journal-title":"PLoS ONE"}],"container-title":["Cellular and Molecular Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-020-03556-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00018-020-03556-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-020-03556-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T00:02:37Z","timestamp":1622073757000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00018-020-03556-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,27]]},"references-count":119,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["3556"],"URL":"https:\/\/doi.org\/10.1007\/s00018-020-03556-1","relation":{},"ISSN":["1420-682X","1420-9071"],"issn-type":[{"value":"1420-682X","type":"print"},{"value":"1420-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,27]]},"assertion":[{"value":"12 April 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 May 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 May 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 May 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}