{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T02:36:44Z","timestamp":1789094204107,"version":"build-2803163510"},"reference-count":220,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T00:00:00Z","timestamp":1604016000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T00:00:00Z","timestamp":1604016000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01KI1726A"],"award-info":[{"award-number":["01KI1726A"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CRC1181-A06"],"award-info":[{"award-number":["CRC1181-A06"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CRC1181-C04"],"award-info":[{"award-number":["CRC1181-C04"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005341","name":"Bayerisches Staatsministerium f\u00fcr Wissenschaft, Forschung und Kunst","doi-asserted-by":"publisher","award":["bayresq.net"],"award-info":[{"award-number":["bayresq.net"]}],"id":[{"id":"10.13039\/501100005341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001652","name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001652","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell. Mol. Life Sci."],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Various factors of the tissue microenvironment such as the oxygen concentration influence the host\u2013pathogen interaction. During the past decade, hypoxia-driven signaling via hypoxia-inducible factors (HIF) has emerged as an important factor that affects both the pathogen and the host. In this chapter, we will review the current knowledge of this complex interplay, with a particular emphasis given to the impact of hypoxia and HIF on the inflammatory and antimicrobial activity of myeloid cells, the bacterial responses to hypoxia and the containment of bacterial infections under oxygen-limited conditions. We will also summarize how low oxygen concentrations influence the metabolism of neutrophils, macrophages and dendritic cells. Finally, we will discuss the consequences of hypoxia and HIF\u03b1 activation for the invading pathogen, with a focus on<jats:italic>Pseudomonas aeruginosa<\/jats:italic>,<jats:italic>Mycobacterium tuberculosis<\/jats:italic>,<jats:italic>Coxiella burnetii<\/jats:italic>,<jats:italic>Salmonella enterica<\/jats:italic>and<jats:italic>Staphylococcus aureus<\/jats:italic>. This includes a description of the mechanisms and microbial factors, which the pathogens use to sense and react to hypoxic conditions.<\/jats:p>","DOI":"10.1007\/s00018-020-03684-8","type":"journal-article","created":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T07:02:37Z","timestamp":1604041357000},"page":"1887-1907","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Mechanisms controlling bacterial infection in myeloid cells under hypoxic conditions"],"prefix":"10.1007","volume":"78","author":[{"given":"Inaya","family":"Hayek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentin","family":"Schatz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Bogdan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Jantsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1224-0880","authenticated-orcid":false,"given":"Anja","family":"L\u00fchrmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,10,30]]},"reference":[{"key":"3684_CR1","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1111\/imm.12597","volume":"148","author":"M Riera Romo","year":"2016","unstructured":"Riera Romo M, P\u00e9rez-Mart\u00ednez D, Castillo Ferrer C (2016) Innate immunity in vertebrates: An overview. Immunology 148:125\u2013139. https:\/\/doi.org\/10.1111\/imm.12597","journal-title":"Immunology"},{"key":"3684_CR2","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1038\/nri.2017.103","volume":"17","author":"CT Taylor","year":"2017","unstructured":"Taylor CT, Colgan SP (2017) Regulation of immunity and inflammation by hypoxia in immunological niches. Nat Rev Immunol 17:774\u2013785. https:\/\/doi.org\/10.1038\/nri.2017.103","journal-title":"Nat Rev Immunol"},{"key":"3684_CR3","doi-asserted-by":"publisher","first-page":"2048","DOI":"10.1016\/j.celrep.2015.11.005","volume":"13","author":"I Siegert","year":"2015","unstructured":"Siegert I, Sch\u00f6del J, Nairz M et al (2015) Ferritin-mediated iron sequestration stabilizes hypoxia-inducible factor-1\u03b1 upon LPS activation in the presence of ample oxygen. Cell Rep 13:2048\u20132055. https:\/\/doi.org\/10.1016\/j.celrep.2015.11.005","journal-title":"Cell Rep"},{"key":"3684_CR4","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1038\/ni.3734","volume":"18","author":"UM Gundra","year":"2017","unstructured":"Gundra UM, Girgis NM, Gonzalez MA et al (2017) Vitamin A mediates conversion of monocyte-derived macrophages into tissue-resident macrophages during alternative activation. Nat Immunol 18:642\u2013653. https:\/\/doi.org\/10.1038\/ni.3734","journal-title":"Nat Immunol"},{"key":"3684_CR5","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.1016\/j.cell.2016.07.026","volume":"166","author":"A Wang","year":"2016","unstructured":"Wang A, Huen SC, Luan HH et al (2016) Opposing effects of fasting metabolism on tissue tolerance in bacterial and viral inflammation. Cell 166:1512-1525.e12. https:\/\/doi.org\/10.1016\/j.cell.2016.07.026","journal-title":"Cell"},{"key":"3684_CR6","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1111\/imr.12266","volume":"264","author":"G Weiss","year":"2015","unstructured":"Weiss G, Schaible UE (2015) Macrophage defense mechanisms against intracellular bacteria. Immunol Rev 264:182\u2013203. https:\/\/doi.org\/10.1111\/imr.12266","journal-title":"Immunol Rev"},{"key":"3684_CR7","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/nri1685","volume":"5","author":"M Sitkovsky","year":"2005","unstructured":"Sitkovsky M, Lukashev D (2005) Regulation of immune cells by local-tissue oxygen tension: HIF1\u03b1 and adenosine receptors. Nat Rev Immunol 5:712\u2013721","journal-title":"Nat Rev Immunol"},{"key":"3684_CR8","doi-asserted-by":"publisher","first-page":"1964","DOI":"10.1038\/jid.2008.27","volume":"128","author":"C Peyssonnaux","year":"2008","unstructured":"Peyssonnaux C, Boutin AT, Zinkernagel AS et al (2008) Critical role of HIF-1\u03b1 in keratinocyte defense against bacterial infection. J Invest Dermatol 128:1964\u20131968. https:\/\/doi.org\/10.1038\/jid.2008.27","journal-title":"J Invest Dermatol"},{"key":"3684_CR9","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/jcp.21908","volume":"222","author":"P Eliasson","year":"2010","unstructured":"Eliasson P, J\u00f6nsson JI (2010) The hematopoietic stem cell niche: Low in oxygen but a nice place to be. J Cell Physiol 222:17\u201322","journal-title":"J Cell Physiol"},{"key":"3684_CR10","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1096\/fj.01-0496fje","volume":"16","author":"A Scheid","year":"2002","unstructured":"Scheid A, Wenger RH, Sch\u00e4ffer L et al (2002) Physiologically low oxygen concentrations in fetal skin regulate hypoxia-inducible factor 1 and transforming growth factor-beta3. FASEB J 16:411\u2013413. https:\/\/doi.org\/10.1096\/fj.01-0496fje","journal-title":"FASEB J"},{"key":"3684_CR11","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.immuni.2013.11.020","volume":"40","author":"EL Campbell","year":"2014","unstructured":"Campbell EL, Bruyninckx WJ, Kelly CJ et al (2014) Transmigrating neutrophils shape the mucosal microenvironment through localized oxygen depletion to influence resolution of inflammation. Immunity 40:66\u201377. https:\/\/doi.org\/10.1016\/j.immuni.2013.11.020","journal-title":"Immunity"},{"key":"3684_CR12","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1172\/jci21086","volume":"114","author":"J Karhausen","year":"2004","unstructured":"Karhausen J, Furuta GT, Tomaszewski JE et al (2004) Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis. J Clin Invest 114:1098\u20131106. https:\/\/doi.org\/10.1172\/jci21086","journal-title":"J Clin Invest"},{"key":"3684_CR13","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/nature08970","volume":"465","author":"B Marteyn","year":"2010","unstructured":"Marteyn B, West NP, Browning DF et al (2010) Modulation of Shigella virulence in response to available oxygen in vivo. Nature 465:355\u2013358. https:\/\/doi.org\/10.1038\/nature08970","journal-title":"Nature"},{"key":"3684_CR14","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1053\/j.gastro.2014.07.020","volume":"147","author":"L Albenberg","year":"2014","unstructured":"Albenberg L, Esipova TV, Judge CP et al (2014) Correlation between intraluminal oxygen gradient and radial partitioning of intestinal microbiota. Gastroenterology 147:1055-1063.e8. https:\/\/doi.org\/10.1053\/j.gastro.2014.07.020","journal-title":"Gastroenterology"},{"key":"3684_CR15","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1016\/j.chom.2015.03.005","volume":"17","author":"CJ Kelly","year":"2015","unstructured":"Kelly CJ, Zheng L, Campbell EL et al (2015) Crosstalk between microbiota-derived short-chain fatty acids and intestinal epithelial HIF augments tissue barrier function. Cell Host Microbe 17:662\u2013671. https:\/\/doi.org\/10.1016\/j.chom.2015.03.005","journal-title":"Cell Host Microbe"},{"key":"3684_CR16","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.imbio.2014.09.009","volume":"220","author":"J Jantsch","year":"2015","unstructured":"Jantsch J, Sch\u00f6del J (2015) Hypoxia and hypoxia-inducible factors in myeloid cell-driven host defense and tissue homeostasis. Immunobiology 220:305\u2013314","journal-title":"Immunobiology"},{"key":"3684_CR17","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.1039\/C4CS00039K","volume":"43","author":"XD Wang","year":"2014","unstructured":"Wang XD, Wolfbeis OS (2014) Optical methods for sensing and imaging oxygen: Materials, spectroscopies and applications. Chem Soc Rev 43:3666\u20133761","journal-title":"Chem Soc Rev"},{"key":"3684_CR18","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3389\/fonc.2017.00010","volume":"7","author":"F Colliez","year":"2017","unstructured":"Colliez F, Gallez B, Jordan BF (2017) Assessing tumor oxygenation for predicting outcome in radiation oncology: A review of studies correlating tumor hypoxic status and outcome in the preclinical and clinical settings. Front Oncol 7:10","journal-title":"Front Oncol"},{"key":"3684_CR19","doi-asserted-by":"crossref","first-page":"129S","DOI":"10.2967\/jnumed.107.045914","volume":"49","author":"KA Krohn","year":"2008","unstructured":"Krohn KA, Link JM, Mason RP (2008) Molecular imaging of hypoxia. J. Nucl. Med. 49:129S\u2013148S","journal-title":"J. Nucl. Med."},{"key":"3684_CR20","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1007\/s00259-009-1195-9","volume":"36","author":"G Mees","year":"2009","unstructured":"Mees G, Dierckx R, Vangestel C, Van De Wiele C (2009) Molecular imaging of hypoxia with radiolabelled agents. Eur J Nucl Med Mol Imaging 36:1674\u20131686","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"3684_CR21","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3389\/fchem.2018.00027","volume":"6","author":"V Mirabello","year":"2018","unstructured":"Mirabello V, Cortezon-Tamarit F, Pascu SI (2018) Oxygen sensing, hypoxia tracing and in vivo imaging with functional metalloprobes for the early detection of non-communicable diseases. Front Chem 6:27. https:\/\/doi.org\/10.3389\/fchem.2018.00027","journal-title":"Front Chem"},{"key":"3684_CR22","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1002\/tcr.201500292","volume":"16","author":"F Cortezon-Tamarit","year":"2016","unstructured":"Cortezon-Tamarit F, Sarpaki S, Calatayud DG et al (2016) Applications of \u201cHot\u201d and \u201cCold\u201d Bis(thiosemicarbazonato) metal complexes in multimodal imaging. Chem Rec 16:1380\u20131397. https:\/\/doi.org\/10.1002\/tcr.201500292","journal-title":"Chem Rec"},{"key":"3684_CR23","doi-asserted-by":"crossref","first-page":"47","DOI":"10.7150\/thno.7447","volume":"4","author":"I Velikyan","year":"2014","unstructured":"Velikyan I (2014) Prospective of 68Ga-Radiopharmaceutical development. Theranostics 4:47\u201380","journal-title":"Theranostics"},{"key":"3684_CR24","first-page":"169","volume":"41","author":"T Melo","year":"2000","unstructured":"Melo T, Duncan J, Ballinger JR, Rauth AM (2000) BRU59-21, a second-generation 99mTc-labeled 2-nitroimidazole for imaging hypoxia in tumors. J Nucl Med 41:169\u2013176","journal-title":"J Nucl Med"},{"key":"3684_CR25","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1007\/s00259-002-0888-0","volume":"29","author":"FJ Hoebers","year":"2002","unstructured":"Hoebers FJ, Janssen HL, Olmos RA et al (2002) Phase 1 study to identify tumour hypoxia in patients with head and neck cancer using technetium-99m BRU 59\u201321. Eur J Nucl Med 29:1206\u20131211. https:\/\/doi.org\/10.1007\/s00259-002-0888-0","journal-title":"Eur J Nucl Med"},{"key":"3684_CR26","doi-asserted-by":"crossref","unstructured":"Honess DJ, Hill SA, Collingridge DR, et al (1998) Preclinical evaluation of the novel hypoxic marker 99mTc-HL91 (prognox) in murine and xenograft systems in vivo. In: International Journal of Radiation Oncology Biology Physics. Elsevier, pp 731\u2013735","DOI":"10.1016\/S0360-3016(98)00300-9"},{"key":"3684_CR27","doi-asserted-by":"crossref","DOI":"10.1002\/9781118854754","volume-title":"The chemistry of molecular imaging","author":"NJ Long","year":"2014","unstructured":"Long NJ, Wong WT (2014) The chemistry of molecular imaging. Wiley, Hoboken"},{"key":"3684_CR28","doi-asserted-by":"publisher","first-page":"1987","DOI":"10.1111\/j.1462-5822.2008.01182.x","volume":"10","author":"K Melican","year":"2008","unstructured":"Melican K, Boekel J, M\u00e5nsson LE et al (2008) Bacterial infection-mediated mucosal signalling induces local renal ischaemia as a defence against sepsis. Cell Microbiol 10:1987\u20131998. https:\/\/doi.org\/10.1111\/j.1462-5822.2008.01182.x","journal-title":"Cell Microbiol"},{"key":"3684_CR29","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.smim.2016.10.010","volume":"28","author":"F Gaertner","year":"2016","unstructured":"Gaertner F, Massberg S (2016) Blood coagulation in immunothrombosis\u2014at the frontline of intravascular immunity. Semin Immunol 28:561\u2013569","journal-title":"Semin Immunol"},{"key":"3684_CR30","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1038\/nm.2184","volume":"16","author":"S Massberg","year":"2010","unstructured":"Massberg S, Grahl L, Von Bruehl ML et al (2010) Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases. Nat Med 16:887\u2013896. https:\/\/doi.org\/10.1038\/nm.2184","journal-title":"Nat Med"},{"key":"3684_CR31","doi-asserted-by":"publisher","first-page":"E3282","DOI":"10.1073\/pnas.1509091112","volume":"112","author":"ET Arena","year":"2015","unstructured":"Arena ET, Campbell-Valois FX, Tinevez JY et al (2015) Bioimage analysis of Shigella infection reveals targeting of colonic crypts. Proc Natl Acad Sci USA 112:E3282\u2013E3290. https:\/\/doi.org\/10.1073\/pnas.1509091112","journal-title":"Proc Natl Acad Sci USA"},{"key":"3684_CR32","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.micinf.2016.10.011","volume":"19","author":"ET Arena","year":"2017","unstructured":"Arena ET, Tinevez JY, Nigro G et al (2017) The infectious hypoxia: occurrence and causes during Shigella infection. Microbes Infect 19:157\u2013165. https:\/\/doi.org\/10.1016\/j.micinf.2016.10.011","journal-title":"Microbes Infect"},{"key":"3684_CR33","doi-asserted-by":"publisher","first-page":"1833","DOI":"10.1111\/cmi.12476","volume":"17","author":"J Jennewein","year":"2015","unstructured":"Jennewein J, Matuszak J, Walter S et al (2015) Low-oxygen tensions found in Salmonella-infected gut tissue boost Salmonella replication in macrophages by impairing antimicrobial activity and augmenting Salmonella virulence. Cell Microbiol 17:1833\u20131847. https:\/\/doi.org\/10.1111\/cmi.12476","journal-title":"Cell Microbiol"},{"key":"3684_CR34","doi-asserted-by":"publisher","first-page":"2001","DOI":"10.1038\/s41564-019-0525-3","volume":"4","author":"JY Tinevez","year":"2019","unstructured":"Tinevez JY, Arena ET, Anderson M et al (2019) Shigella-mediated oxygen depletion is essential for intestinal mucosa colonization. Nat Microbiol 4:2001\u20132009. https:\/\/doi.org\/10.1038\/s41564-019-0525-3","journal-title":"Nat Microbiol"},{"key":"3684_CR35","doi-asserted-by":"publisher","first-page":"37513","DOI":"10.18632\/oncotarget.7038","volume":"7","author":"DG Tu","year":"2016","unstructured":"Tu DG, Chang WW, Lin ST et al (2016) Salmonella inhibits tumor angiogenesis by downregulation of vascular endothelial growth factor. Oncotarget 7:37513. https:\/\/doi.org\/10.18632\/oncotarget.7038","journal-title":"Oncotarget"},{"key":"3684_CR36","doi-asserted-by":"publisher","first-page":"514","DOI":"10.4049\/jimmunol.1800422","volume":"202","author":"P Rao","year":"2019","unstructured":"Rao P, Suvas S (2019) Development of inflammatory hypoxia and prevalence of glycolytic metabolism in progressing herpes stromal keratitis lesions. J Immunol 202:514\u2013526. https:\/\/doi.org\/10.4049\/jimmunol.1800422","journal-title":"J Immunol"},{"key":"3684_CR37","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02120-18","author":"JP Lopes","year":"2018","unstructured":"Lopes JP, Stylianou M, Backman E et al (2018) Evasion of immune surveillance in low oxygen environments enhances candida albicans virulence. MBio. https:\/\/doi.org\/10.1128\/mBio.02120-18","journal-title":"MBio"},{"key":"3684_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep26490","volume":"6","author":"MS Gresnigt","year":"2016","unstructured":"Gresnigt MS, Rekiki A, Rasid O et al (2016) Reducing hypoxia and inflammation during invasive pulmonary aspergillosis by targeting the Interleukin-1 receptor. Sci Rep 6:1\u201312. https:\/\/doi.org\/10.1038\/srep26490","journal-title":"Sci Rep"},{"key":"3684_CR39","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nri.2016.70","volume":"16","author":"LAJ O\u2019Neill","year":"2016","unstructured":"O\u2019Neill LAJ, Kishton RJ, Rathmell J (2016) A guide to immunometabolism for immunologists. Nat Rev Immunol 16:553\u2013565","journal-title":"Nat Rev Immunol"},{"key":"3684_CR40","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1002\/JLB.4RI0518-195R","volume":"105","author":"LC Davies","year":"2019","unstructured":"Davies LC, Rice CM, McVicar DW, Weiss JM (2019) Diversity and environmental adaptation of phagocytic cell metabolism. J Leukoc Biol 105:37\u201348. https:\/\/doi.org\/10.1002\/JLB.4RI0518-195R","journal-title":"J Leukoc Biol"},{"key":"3684_CR41","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1002\/bies.201300084","volume":"35","author":"EM Palsson-Mcdermott","year":"2013","unstructured":"Palsson-Mcdermott EM, O\u2019Neill LAJ (2013) The Warburg effect then and now: From cancer to inflammatory diseases. BioEssays 35:965\u2013973. https:\/\/doi.org\/10.1002\/bies.201300084","journal-title":"BioEssays"},{"key":"3684_CR42","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201847388","author":"P Sadiku","year":"2019","unstructured":"Sadiku P, Walmsley SR (2019) Hypoxia and the regulation of myeloid cell metabolic imprinting: consequences for the inflammatory response. EMBO Rep. https:\/\/doi.org\/10.15252\/embr.201847388","journal-title":"EMBO Rep"},{"key":"3684_CR43","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.cmet.2015.06.014","volume":"22","author":"PJ Murray","year":"2015","unstructured":"Murray PJ, Rathmell J, Pearce E (2015) SnapShot: immunometabolism. Cell Metab 22:190-190.e1","journal-title":"Cell Metab"},{"key":"3684_CR44","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1084\/jem.20151570","volume":"213","author":"LAJ O\u2019Neill","year":"2016","unstructured":"O\u2019Neill LAJ, Pearce EJ (2016) Immunometabolism governs dendritic cell and macrophage function. J Exp Med 213:15\u201323","journal-title":"J Exp Med"},{"key":"3684_CR45","doi-asserted-by":"crossref","first-page":"3699","DOI":"10.1172\/JCI84431","volume":"126","author":"SE Corcoran","year":"2016","unstructured":"Corcoran SE, O\u2019Neill LAJ (2016) HIF1\u03b1 and metabolic reprogramming in inflammation. J Clin Invest 126:3699\u20133707","journal-title":"J Clin Invest"},{"key":"3684_CR46","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.cell.2017.04.004","volume":"169","author":"MD Buck","year":"2017","unstructured":"Buck MD, Sowell RT, Kaech SM, Pearce EL (2017) Metabolic Instruction of Immunity. Cell 169:570\u2013586","journal-title":"Cell"},{"key":"3684_CR47","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/s41577-019-0128-5","volume":"19","author":"LAJ O\u2019Neill","year":"2019","unstructured":"O\u2019Neill LAJ, Artyomov MN (2019) Itaconate: the poster child of metabolic reprogramming in macrophage function. Nat Rev Immunol 19:273\u2013281","journal-title":"Nat Rev Immunol"},{"key":"3684_CR48","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.molimm.2015.07.034","volume":"68","author":"RP Donnelly","year":"2015","unstructured":"Donnelly RP, Finlay DK (2015) Glucose, glycolysis and lymphocyte responses. Mol Immunol 68:513\u2013519. https:\/\/doi.org\/10.1016\/j.molimm.2015.07.034","journal-title":"Mol Immunol"},{"key":"3684_CR49","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1152\/physrev.00030.2011","volume":"92","author":"NR Prabhakar","year":"2012","unstructured":"Prabhakar NR, Semenza GL (2012) Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2. Physiol Rev 92:967\u20131003","journal-title":"Physiol Rev"},{"key":"3684_CR50","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.molcel.2008.04.009","volume":"30","author":"WG Kaelin","year":"2008","unstructured":"Kaelin WG, Ratcliffe PJ (2008) Oxygen sensing by metazoans: the central role of the hif hydroxylase pathway. Mol Cell 30:393\u2013402","journal-title":"Mol Cell"},{"key":"3684_CR51","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1007\/s00109-018-1710-1","volume":"96","author":"CL Stothers","year":"2018","unstructured":"Stothers CL, Luan L, Fensterheim BA, Bohannon JK (2018) Hypoxia-inducible factor-1\u03b1 regulation of myeloid cells. J Mol Med 96:1293\u20131306","journal-title":"J Mol Med"},{"key":"3684_CR52","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1007\/s00424-019-02334-8","volume":"471","author":"J Fandrey","year":"2019","unstructured":"Fandrey J, Sch\u00f6del J, Eckardt KU et al (2019) Now a Nobel gas: oxygen. Pflugers Arch Eur J Physiol 471:1343\u20131358","journal-title":"Pflugers Arch Eur J Physiol"},{"key":"3684_CR53","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s10456-018-9600-2","volume":"21","author":"M Serocki","year":"2018","unstructured":"Serocki M, Bartoszewska S, Janaszak-Jasiecka A et al (2018) miRNAs regulate the HIF switch during hypoxia: a novel therapeutic target. Angiogenesis 21:183\u2013202","journal-title":"Angiogenesis"},{"key":"3684_CR54","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1038\/ni1008-1091","volume":"9","author":"TSP Heng","year":"2008","unstructured":"Heng TSP, Painter MW, Elpek K et al (2008) The immunological genome project: Networks of gene expression in immune cells. Nat Immunol 9:1091\u20131094","journal-title":"Nat Immunol"},{"key":"3684_CR55","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1101\/gad.11.1.72","volume":"11","author":"H Tian","year":"1997","unstructured":"Tian H, McKnight SL, Russell DW (1997) Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev 11:72\u201382. https:\/\/doi.org\/10.1101\/gad.11.1.72","journal-title":"Genes Dev"},{"key":"3684_CR56","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1096\/fj.02-0445fje","volume":"17","author":"MS Wiesener","year":"2003","unstructured":"Wiesener MS, J\u00fcrgensen JS, Rosenberger C et al (2003) Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs. FASEB J 17:271\u2013273. https:\/\/doi.org\/10.1096\/fj.02-0445fje","journal-title":"FASEB J"},{"key":"3684_CR57","doi-asserted-by":"publisher","first-page":"2699","DOI":"10.1172\/JCI39506","volume":"120","author":"HZ Imtiyaz","year":"2010","unstructured":"Imtiyaz HZ, Williams EP, Hickey MM et al (2010) Hypoxia-inducible factor 2\u03b1 regulates macrophage function in mouse models of acute and tumor inflammation. J Clin Invest 120:2699\u20132714. https:\/\/doi.org\/10.1172\/JCI39506","journal-title":"J Clin Invest"},{"key":"3684_CR58","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1182\/blood-2013-05-500207","volume":"123","author":"AAR Thompson","year":"2014","unstructured":"Thompson AAR, Elks PM, Marriott HM et al (2014) Hypoxia-inducible factor 2a regulates key neutrophil functions in humans, mice, and zebrafish. Blood 123:366\u2013376. https:\/\/doi.org\/10.1182\/blood-2013-05-500207","journal-title":"Blood"},{"key":"3684_CR59","doi-asserted-by":"publisher","first-page":"C260","DOI":"10.1152\/ajpcell.00315.2015","volume":"310","author":"C Duan","year":"2016","unstructured":"Duan C (2016) Hypoxia-inducible factor 3 biology: complexities and emerging themes. Am J Physiol - Cell Physiol 310:C260\u2013C269. https:\/\/doi.org\/10.1152\/ajpcell.00315.2015","journal-title":"Am J Physiol - Cell Physiol"},{"key":"3684_CR60","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.46490","author":"ME Cockman","year":"2019","unstructured":"Cockman ME, Lippl K, Tian YM et al (2019) Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates. Elife. https:\/\/doi.org\/10.7554\/eLife.46490","journal-title":"Elife"},{"key":"3684_CR61","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1038\/emboj.2012.125","volume":"31","author":"SN Greer","year":"2012","unstructured":"Greer SN, Metcalf JL, Wang Y, Ohh M (2012) The updated biology of hypoxia-inducible factor. EMBO J 31:2448\u20132460","journal-title":"EMBO J"},{"key":"3684_CR62","doi-asserted-by":"publisher","first-page":"16767","DOI":"10.1074\/jbc.M901790200","volume":"284","author":"DR Mole","year":"2009","unstructured":"Mole DR, Blancher C, Copley RR et al (2009) Genome-wide association of hypoxia-inducible factor (HIF)-1\u03b1 and HIF-2\u03b1 DNA binding with expression profiling of hypoxia-inducible transcripts. J Biol Chem 284:16767\u201316775. https:\/\/doi.org\/10.1074\/jbc.M901790200","journal-title":"J Biol Chem"},{"key":"3684_CR63","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1515\/hsz-2012-0351","volume":"394","author":"J Sch\u00f6del","year":"2013","unstructured":"Sch\u00f6del J, Mole DR, Ratcliffe PJ (2013) Pan-genomic binding of hypoxia-inducible transcription factors. Biol Chem 394:507\u2013517","journal-title":"Biol Chem"},{"key":"3684_CR64","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.immuni.2014.09.008","volume":"41","author":"A Palazon","year":"2014","unstructured":"Palazon A, Goldrath AW, Nizet V, Johnson RS (2014) HIF transcription factors, inflammation, and immunity. Immunity 41:518\u2013528","journal-title":"Immunity"},{"key":"3684_CR65","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.micinf.2016.11.003","volume":"19","author":"G Devraj","year":"2017","unstructured":"Devraj G, Beerlage C, Br\u00fcne B, Kempf VAJ (2017) Hypoxia and HIF-1 activation in bacterial infections. Microbes Infect 19:144\u2013156. https:\/\/doi.org\/10.1016\/j.micinf.2016.11.003","journal-title":"Microbes Infect"},{"key":"3684_CR66","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1016\/j.yexcr.2009.03.019","volume":"315","author":"N Dehne","year":"2009","unstructured":"Dehne N, Br\u00fcne B (2009) HIF-1 in the inflammatory microenvironment. Exp Cell Res 315:1791\u20131797","journal-title":"Exp Cell Res"},{"key":"3684_CR67","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0011576","volume":"5","author":"N Werth","year":"2010","unstructured":"Werth N, Beerlage C, Rosenberger C et al (2010) Activation of hypoxia inducible factor 1 is a general phenomenon in infections with human pathogens. PLoS ONE 5:1\u201312. https:\/\/doi.org\/10.1371\/journal.pone.0011576","journal-title":"PLoS ONE"},{"key":"3684_CR68","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1182\/blood-2003-07-2427","volume":"103","author":"CC Blouin","year":"2004","unstructured":"Blouin CC, Pag\u00e9 EL, Soucy GM, Richard DE (2004) Hypoxic gene activation by lipopolysaccharide in macrophages: Implication of hypoxia-inducible factor 1\u03b1. Blood 103:1124\u20131130. https:\/\/doi.org\/10.1182\/blood-2003-07-2427","journal-title":"Blood"},{"key":"3684_CR69","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1042\/BJ20051839","volume":"396","author":"S Frede","year":"2006","unstructured":"Frede S, Stockmann C, Freitag P, Fandrey J (2006) Bacterial lipopolysaccharide induces HIF-1 activation in human monocytes via p44\/42 MAPK and NF-\u03baB. Biochem J 396:517\u2013527. https:\/\/doi.org\/10.1042\/BJ20051839","journal-title":"Biochem J"},{"key":"3684_CR70","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1038\/nature06905","volume":"453","author":"J Rius","year":"2008","unstructured":"Rius J, Guma M, Schachtrup C et al (2008) NF-\u03baB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1\u03b1. Nature 453:807\u2013811. https:\/\/doi.org\/10.1038\/nature06905","journal-title":"Nature"},{"key":"3684_CR71","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1038\/icb.2009.76","volume":"88","author":"SA Nicholas","year":"2010","unstructured":"Nicholas SA, Sumbayev VV (2010) The role of redox-dependent mechanisms in the downregulation of ligand-induced Toll-like receptors 7, 8 and 4-mediated HIF-1\u03b1 prolyl hydroxylation. Immunol Cell Biol 88:180\u2013186. https:\/\/doi.org\/10.1038\/icb.2009.76","journal-title":"Immunol Cell Biol"},{"key":"3684_CR72","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.celrep.2019.06.018","volume":"28","author":"JD Bailey","year":"2019","unstructured":"Bailey JD, Diotallevi M, Nicol T et al (2019) Nitric oxide modulates metabolic remodeling in inflammatory macrophages through TCA cycle regulation and itaconate accumulation. Cell Rep 28:218-230.e7. https:\/\/doi.org\/10.1016\/j.celrep.2019.06.018","journal-title":"Cell Rep"},{"key":"3684_CR73","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/ncomms15620","volume":"8","author":"SJ Lawless","year":"2017","unstructured":"Lawless SJ, Kedia-Mehta N, Walls JF et al (2017) Glucose represses dendritic cell-induced T cell responses. Nat Commun 8:1\u201314. https:\/\/doi.org\/10.1038\/ncomms15620","journal-title":"Nat Commun"},{"key":"3684_CR74","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/J.CELL.2016.08.064","volume":"167","author":"EL Mills","year":"2016","unstructured":"Mills EL, Kelly B, Logan A et al (2016) Succinate dehydrogenase supports metabolic repurposing of mitochondria to drive inflammatory macrophages. Cell 167:457-470.e13. https:\/\/doi.org\/10.1016\/J.CELL.2016.08.064","journal-title":"Cell"},{"key":"3684_CR75","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1038\/nature11986","volume":"496","author":"GM Tannahill","year":"2013","unstructured":"Tannahill GM, Curtis AM, Adamik J et al (2013) Succinate is an inflammatory signal that induces IL-1\u03b2 through HIF-1\u03b1. Nature 496:238\u2013242. https:\/\/doi.org\/10.1038\/nature11986","journal-title":"Nature"},{"key":"3684_CR76","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1189\/jlb.1210683","volume":"90","author":"J Jantsch","year":"2011","unstructured":"Jantsch J, Wiese M, Sch\u00f6del J et al (2011) Toll-like receptor activation and hypoxia use distinct signaling pathways to stabilize hypoxia-inducible factor 1\u03b1 (HIF1A) and result in differential HIF1A-dependent gene expression. J Leukoc Biol 90:551\u2013562. https:\/\/doi.org\/10.1189\/jlb.1210683","journal-title":"J Leukoc Biol"},{"key":"3684_CR77","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/s41586-019-1485-8","volume":"573","author":"AG Solis","year":"2019","unstructured":"Solis AG, Bielecki P, Steach HR et al (2019) Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity. Nature 573:69\u201374. https:\/\/doi.org\/10.1038\/s41586-019-1485-8","journal-title":"Nature"},{"key":"3684_CR78","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1054\/mehy.2001.1288","volume":"57","author":"S Kurbel","year":"2001","unstructured":"Kurbel S, Kurbel B, Belovari T et al (2001) Model of interstitial pressure as a result of cyclical changes in the capillary wall fluid transport. Med Hypotheses 57:161\u2013166. https:\/\/doi.org\/10.1054\/mehy.2001.1288","journal-title":"Med Hypotheses"},{"key":"3684_CR79","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.12.008","author":"H Hartmann","year":"2008","unstructured":"Hartmann H, Eltzschig HK, Wurz H et al (2008) Hypoxia-independent activation of HIF-1 by enterobacteriaceae and their siderophores. Gastroenterology. https:\/\/doi.org\/10.1053\/j.gastro.2007.12.008","journal-title":"Gastroenterology"},{"key":"3684_CR80","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1084\/jem.20040500","volume":"200","author":"T Riess","year":"2004","unstructured":"Riess T, Andersson SGE, Lupas A et al (2004) Bartonella adhesin A mediates a proangiogenic host cell response. J Exp Med 200:1267\u20131278. https:\/\/doi.org\/10.1084\/jem.20040500","journal-title":"J Exp Med"},{"key":"3684_CR81","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1161\/01.CIR.0000155608.07691.B7","volume":"111","author":"VAJ Kempf","year":"2005","unstructured":"Kempf VAJ, Lebiedziejewski M, Alitalo K et al (2005) Activation of hypoxia-inducible factor-1 in bacillary angiomatosis: evidence for a role of hypoxia-inducible factor-1 in bacterial infections. Circulation 111:1054\u20131062. https:\/\/doi.org\/10.1161\/01.CIR.0000155608.07691.B7","journal-title":"Circulation"},{"key":"3684_CR82","doi-asserted-by":"publisher","first-page":"3985","DOI":"10.1128\/IAI.00554-12","volume":"80","author":"C Legendre","year":"2012","unstructured":"Legendre C, Reen FJ, Mooij MJ et al (2012) Pseudomonas aeruginosa Alkyl quinolones repress hypoxia-inducible factor 1 (HIF-1) signaling through HIF-1\u03b1 degradation. Infect Immun 80:3985\u20133992. https:\/\/doi.org\/10.1128\/IAI.00554-12","journal-title":"Infect Immun"},{"key":"3684_CR83","doi-asserted-by":"publisher","first-page":"2181","DOI":"10.1111\/j.1462-5822.2007.00948.x","volume":"9","author":"J Rupp","year":"2007","unstructured":"Rupp J, Gieffers J, Klinger M et al (2007) Chlamydia pneumoniae directly interferes with HIF-1\u03b1 stabilization in human host cells. Cell Microbiol 9:2181\u20132191. https:\/\/doi.org\/10.1111\/j.1462-5822.2007.00948.x","journal-title":"Cell Microbiol"},{"key":"3684_CR84","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.it.2005.06.007","volume":"26","author":"SR Walmsley","year":"2005","unstructured":"Walmsley SR, Cadwallader KA, Chilvers ER (2005) The role of HIF-1\u03b1 in myeloid cell inflammation. Trends Immunol 26:434\u2013439","journal-title":"Trends Immunol"},{"key":"3684_CR85","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1038\/sj.cdd.4401320","volume":"11","author":"NA Maianski","year":"2004","unstructured":"Maianski NA, Geissler J, Srinivasula SM et al (2004) Functional characterization of mitochondria in neutrophils: A role restricted to apoptosis. Cell Death Differ 11:143\u2013153. https:\/\/doi.org\/10.1038\/sj.cdd.4401320","journal-title":"Cell Death Differ"},{"key":"3684_CR86","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/S0092-8674(03)00154-5","volume":"112","author":"T Cramer","year":"2003","unstructured":"Cramer T, Yamanishi Y, Clausen BE et al (2003) HIF-1\u03b1 is essential for myeloid cell-mediated inflammation. Cell 112:645\u2013657. https:\/\/doi.org\/10.1016\/S0092-8674(03)00154-5","journal-title":"Cell"},{"key":"3684_CR87","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1084\/jem.20040624","volume":"201","author":"SR Walmsley","year":"2005","unstructured":"Walmsley SR, Print C, Farahi N et al (2005) Hypoxia-induced neutrophil survival is mediated by HIF-1\u03b1-dependent NF-\u03baB activity. J Exp Med 201:105\u2013115. https:\/\/doi.org\/10.1084\/jem.20040624","journal-title":"J Exp Med"},{"key":"3684_CR88","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00350.2006","author":"DP Schuster","year":"2007","unstructured":"Schuster DP, Brody SL, Zhou Z et al (2007) Regulation of lipopolysaccharide-induced increases in neutrophil glucose uptake. Am J Physiol Lung Cell Mol Physiol. https:\/\/doi.org\/10.1152\/ajplung.00350.2006","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"3684_CR89","doi-asserted-by":"publisher","first-page":"3407","DOI":"10.1172\/JCI90848","volume":"127","author":"P Sadiku","year":"2017","unstructured":"Sadiku P, Willson JA, Dickinson RS et al (2017) Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses. J Clin Invest 127:3407\u20133420. https:\/\/doi.org\/10.1172\/JCI90848","journal-title":"J Clin Invest"},{"key":"3684_CR90","doi-asserted-by":"publisher","first-page":"1806","DOI":"10.1172\/JCI23865","volume":"115","author":"C Peyssonnaux","year":"2005","unstructured":"Peyssonnaux C, Datta V, Cramer T et al (2005) HIF-1alpha expression regulates the bactericidal capacity of phagocytes. J Clin Invest 115:1806\u20131815. https:\/\/doi.org\/10.1172\/JCI23865","journal-title":"J Clin Invest"},{"key":"3684_CR91","doi-asserted-by":"publisher","first-page":"3118","DOI":"10.1182\/blood-2012-01-405993","volume":"120","author":"AM McInturff","year":"2012","unstructured":"McInturff AM, Cody MJ, Elliott EA et al (2012) Mammalian target of rapamycin regulates neutrophil extracellular trap formation via induction of hypoxia-inducible factor 1 \u03b1. Blood 120:3118\u20133125. https:\/\/doi.org\/10.1182\/blood-2012-01-405993","journal-title":"Blood"},{"key":"3684_CR92","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1182\/blood-2015-11-680918","volume":"128","author":"V Monceaux","year":"2016","unstructured":"Monceaux V, Chiche-Lapierre C, Chaput C et al (2016) Anoxia and glucose supplementation preserve neutrophil viability and function. Blood 128:993\u20131002. https:\/\/doi.org\/10.1182\/blood-2015-11-680918","journal-title":"Blood"},{"key":"3684_CR93","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.cmet.2014.12.005","volume":"21","author":"EM Palsson-Mcdermott","year":"2015","unstructured":"Palsson-Mcdermott EM, Curtis AM, Goel G et al (2015) Pyruvate kinase M2 regulates hif-1\u03b1 activity and il-1\u03b2 induction and is a critical determinant of the warburg effect in LPS-activated macrophages. Cell Metab 21:65\u201380. https:\/\/doi.org\/10.1016\/j.cmet.2014.12.005","journal-title":"Cell Metab"},{"key":"3684_CR94","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1111\/j.1365-2567.2009.03203.x","volume":"129","author":"SY Kim","year":"2010","unstructured":"Kim SY, Choi YJ, Joung SM et al (2010) Hypoxic stress up-regulates the expression of Toll-like receptor 4 in macrophages via hypoxia-inducible factor. Immunology 129:516\u2013524. https:\/\/doi.org\/10.1111\/j.1365-2567.2009.03203.x","journal-title":"Immunology"},{"key":"3684_CR95","doi-asserted-by":"publisher","first-page":"3502","DOI":"10.1016\/j.celrep.2019.02.103","volume":"26","author":"I Hayek","year":"2019","unstructured":"Hayek I, Fischer F, Schulze-Luehrmann J et al (2019) Limitation of TCA cycle intermediates represents an oxygen-independent nutritional antibacterial effector mechanism of macrophages. Cell Rep 26:3502-3510.e6. https:\/\/doi.org\/10.1016\/j.celrep.2019.02.103","journal-title":"Cell Rep"},{"key":"3684_CR96","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.ppat.1003789","volume":"9","author":"PM Elks","year":"2013","unstructured":"Elks PM, Brizee S, van der Vaart M et al (2013) Hypoxia inducible factor signaling modulates susceptibility to mycobacterial infection via a nitric oxide dependent mechanism. PLoS Pathog 9:1\u201316. https:\/\/doi.org\/10.1371\/journal.ppat.1003789","journal-title":"PLoS Pathog"},{"key":"3684_CR97","doi-asserted-by":"publisher","first-page":"3039","DOI":"10.1182\/blood-2006-12-063289","volume":"110","author":"HK Bayele","year":"2007","unstructured":"Bayele HK, Peyssonnaux C, Giatromanolaki A et al (2007) HIF-1 regulates heritable variation and allele expression phenotypes of the macrophage immune response gene SLC11A1 from a Z-DNA-forming microsatellite. Blood 110:3039\u20133048. https:\/\/doi.org\/10.1182\/blood-2006-12-063289","journal-title":"Blood"},{"key":"3684_CR98","doi-asserted-by":"publisher","first-page":"4034","DOI":"10.4049\/jimmunol.1601080","volume":"197","author":"V Schatz","year":"2016","unstructured":"Schatz V, Str\u00fcssmann Y, Mahnke A et al (2016) Myeloid cell-derived HIF-1\u03b1 promotes control of leishmania major. J Immunol 197:4034\u20134041. https:\/\/doi.org\/10.4049\/jimmunol.1601080","journal-title":"J Immunol"},{"key":"3684_CR99","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1101\/gad.1881410","volume":"24","author":"N Takeda","year":"2010","unstructured":"Takeda N, O\u2019Dea EL, Doedens A et al (2010) Differential activation and antagonistic function of HIF-\u03b1 isoforms in macrophages are essential for NO homeostasis. Genes Dev 24:491\u2013501. https:\/\/doi.org\/10.1101\/gad.1881410","journal-title":"Genes Dev"},{"key":"3684_CR100","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/cr.2015.68","volume":"25","author":"B Kelly","year":"2015","unstructured":"Kelly B, O\u2019Neill LAJ (2015) Metabolic reprogramming in macrophages and dendritic cells in innate immunity. Cell Res 25:771\u2013784","journal-title":"Cell Res"},{"key":"3684_CR101","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.1182\/blood-2012-03-419747","volume":"120","author":"B Everts","year":"2012","unstructured":"Everts B, Amiel E, Van Der Windt GJW et al (2012) Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells. Blood 120:1422\u20131431. https:\/\/doi.org\/10.1182\/blood-2012-03-419747","journal-title":"Blood"},{"key":"3684_CR102","doi-asserted-by":"publisher","first-page":"5134329","DOI":"10.1155\/2016\/5134329","volume":"2016","author":"S Winning","year":"2016","unstructured":"Winning S, Fandrey J (2016) Dendritic cells under hypoxia: how oxygen shortage affects the linkage between innate and adaptive immunity. J Immunol Res 2016:5134329\u20135134329. https:\/\/doi.org\/10.1155\/2016\/5134329","journal-title":"J Immunol Res"},{"key":"3684_CR103","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.4049\/jimmunol.1701522","volume":"201","author":"L Perrin-Cocon","year":"2018","unstructured":"Perrin-Cocon L, Aublin-Gex A, Diaz O et al (2018) Toll-like receptor 4\u2013induced glycolytic burst in human monocyte-derived dendritic cells results from p38-dependent stabilization of HIF-1\u03b1 and increased hexokinase II expression. J Immunol 201:1510\u20131521. https:\/\/doi.org\/10.4049\/jimmunol.1701522","journal-title":"J Immunol"},{"key":"3684_CR104","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04804-6","author":"H Guak","year":"2018","unstructured":"Guak H, Al Habyan S, Ma EH et al (2018) Glycolytic metabolism is essential for CCR7 oligomerization and dendritic cell migration. Nat Commun. https:\/\/doi.org\/10.1038\/s41467-018-04804-6","journal-title":"Nat Commun"},{"key":"3684_CR105","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1002\/eji.201142053","volume":"42","author":"T K\u00f6hler","year":"2012","unstructured":"K\u00f6hler T, Reizis B, Johnson RS et al (2012) Influence of hypoxia-inducible factor 1\u03b1 on dendritic cell differentiation and migration. Eur J Immunol 42:1226\u20131236. https:\/\/doi.org\/10.1002\/eji.201142053","journal-title":"Eur J Immunol"},{"key":"3684_CR106","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1016\/j.immuni.2019.01.021","volume":"50","author":"J Liu","year":"2019","unstructured":"Liu J, Zhang X, Chen K et al (2019) CCR7 chemokine receptor-inducible lnc-Dpf3 restrains dendritic cell migration by inhibiting HIF-1\u03b1-mediated glycolysis. Immunity 50:600-615.e15. https:\/\/doi.org\/10.1016\/j.immuni.2019.01.021","journal-title":"Immunity"},{"key":"3684_CR107","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1007\/s00109-013-1052-y","volume":"91","author":"T Bhandari","year":"2013","unstructured":"Bhandari T, Olson J, Johnson RS, Nizet V (2013) HIF-1\u03b1 influences myeloid cell antigen presentation and response to subcutaneous OVA vaccination. J Mol Med 91:1199\u20131205. https:\/\/doi.org\/10.1007\/s00109-013-1052-y","journal-title":"J Mol Med"},{"key":"3684_CR108","doi-asserted-by":"publisher","first-page":"4697","DOI":"10.4049\/jimmunol.180.7.4697","volume":"180","author":"J Jantsch","year":"2008","unstructured":"Jantsch J, Chakravortty D, Turza N et al (2008) Hypoxia and hypoxia-inducible factor-1\u03b1 modulate lipopolysaccharide-induced dendritic cell activation and function. J Immunol 180:4697\u20134705. https:\/\/doi.org\/10.4049\/jimmunol.180.7.4697","journal-title":"J Immunol"},{"key":"3684_CR109","doi-asserted-by":"publisher","first-page":"e1001759","DOI":"10.1371\/journal.pbio.1001759","volume":"12","author":"A Pantel","year":"2014","unstructured":"Pantel A, Teixeira A, Haddad E et al (2014) Direct type I IFN but Not MDA5\/TLR3 activation of dendritic cells is required for maturation and metabolic shift to glycolysis after poly IC stimulation. PLoS Biol 12:e1001759. https:\/\/doi.org\/10.1371\/journal.pbio.1001759","journal-title":"PLoS Biol"},{"key":"3684_CR110","doi-asserted-by":"publisher","first-page":"e10983","DOI":"10.1371\/journal.pone.0010983","volume":"5","author":"R Spirig","year":"2010","unstructured":"Spirig R, Djafarzadeh S, Regueira T et al (2010) Effects of TLR agonists on the hypoxia-regulated transcription factor HIF-1\u03b1 and dendritic cell maturation under normoxic conditions. PLoS ONE 5:e10983. https:\/\/doi.org\/10.1371\/journal.pone.0010983","journal-title":"PLoS ONE"},{"key":"3684_CR111","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1038\/ni.2833","volume":"15","author":"B Everts","year":"2014","unstructured":"Everts B, Amiel E, Huang SCC et al (2014) TLR-driven early glycolytic reprogramming via the kinases TBK1-IKK\u03b5 supports the anabolic demands of dendritic cell activation. Nat Immunol 15:323\u2013332. https:\/\/doi.org\/10.1038\/ni.2833","journal-title":"Nat Immunol"},{"key":"3684_CR112","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.chom.2011.04.006","volume":"9","author":"MG Netea","year":"2011","unstructured":"Netea MG, Quintin J, Van Der Meer JWM (2011) Trained immunity: a memory for innate host defense. Cell Host Microbe 9:355\u2013361","journal-title":"Cell Host Microbe"},{"key":"3684_CR113","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.it.2018.11.002","volume":"40","author":"S Penkov","year":"2019","unstructured":"Penkov S, Mitroulis I, Hajishengallis G, Chavakis T (2019) Immunometabolic crosstalk: an ancestral principle of trained immunity? Trends Immunol 40:1\u201311","journal-title":"Trends Immunol"},{"key":"3684_CR114","doi-asserted-by":"publisher","DOI":"10.1126\/science.1250684","author":"SC Cheng","year":"2014","unstructured":"Cheng SC, Quintin J, Cramer RA et al (2014) MTOR- and HIF-1\u03b1-mediated aerobic glycolysis as metabolic basis for trained immunity. Science (80-). https:\/\/doi.org\/10.1126\/science.1250684","journal-title":"Science (80-)"},{"key":"3684_CR115","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1016\/j.stem.2020.01.017","volume":"26","author":"B de Laval","year":"2020","unstructured":"de Laval B, Maurizio J, Kandalla PK et al (2020) Erratum: C\/EBP\u03b2-dependent epigenetic memory induces trained immunity in hematopoietic stem cells. Cell Stem Cell 26:793. https:\/\/doi.org\/10.1016\/j.stem.2020.01.017 ((26(5) (657\u2013674.e8))","journal-title":"Cell Stem Cell"},{"key":"3684_CR116","doi-asserted-by":"publisher","first-page":"3777","DOI":"10.4049\/jimmunol.1800085","volume":"200","author":"BA Fensterheim","year":"2018","unstructured":"Fensterheim BA, Young JD, Luan L et al (2018) The TLR4 agonist monophosphoryl lipid A drives broad resistance to infection via dynamic reprogramming of macrophage metabolism. J Immunol 200:3777\u20133789. https:\/\/doi.org\/10.4049\/jimmunol.1800085","journal-title":"J Immunol"},{"key":"3684_CR117","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aal2861","author":"AAR Thompson","year":"2017","unstructured":"Thompson AAR, Dickinson RS, Murphy F et al (2017) Hypoxia determines survival outcomes of bacterial infection through HIF-1\u03b1\u2013dependent reprogramming of leukocyte metabolism. Sci Immunol. https:\/\/doi.org\/10.1126\/sciimmunol.aal2861","journal-title":"Sci Immunol"},{"key":"3684_CR118","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/bs.aambs.2016.04.002","volume":"95","author":"N Wallace","year":"2016","unstructured":"Wallace N, Zani A, Abrams E, Sun Y (2016) The impact of oxygen on bacterial enteric pathogens. Adv Appl Microbiol 95:179\u2013204. https:\/\/doi.org\/10.1016\/bs.aambs.2016.04.002","journal-title":"Adv Appl Microbiol"},{"key":"3684_CR119","doi-asserted-by":"publisher","first-page":"3917","DOI":"10.1021\/acs.jproteome.7b00561","volume":"16","author":"KS Kamath","year":"2017","unstructured":"Kamath KS, Krisp C, Chick J et al (2017) Pseudomonas aeruginosa proteome under hypoxic stress conditions mimicking the cystic fibrosis lung. J Proteome Res 16:3917\u20133928. https:\/\/doi.org\/10.1021\/acs.jproteome.7b00561","journal-title":"J Proteome Res"},{"key":"3684_CR120","doi-asserted-by":"publisher","first-page":"13331","DOI":"10.1073\/pnas.1409916111","volume":"111","author":"JS Scotti","year":"2014","unstructured":"Scotti JS, Leung IKH, Ge W et al (2014) Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation. Proc Natl Acad Sci U S A 111:13331\u201313336. https:\/\/doi.org\/10.1073\/pnas.1409916111","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3684_CR121","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1093\/infdis\/jix139","volume":"215","author":"B Schaible","year":"2017","unstructured":"Schaible B, Rodriguez J, Garcia A et al (2017) Hypoxia reduces the pathogenicity of Pseudomonas aeruginosa by decreasing the expression of multiple virulence factors. J Infect Dis 215:1459\u20131467. https:\/\/doi.org\/10.1093\/infdis\/jix139","journal-title":"J Infect Dis"},{"key":"3684_CR122","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.ra119.010033","author":"B Schaible","year":"2019","unstructured":"Schaible B, Crifo B, Schaffer K, Taylor CT (2019) Pseudomonas Prolyl Hydroxylase (PPHD), a putative bacterial oxygen sensor suppresses antibiotic resistance and pathogenicity in Pseudomonas aeruginosa. J Biol Chem. https:\/\/doi.org\/10.1074\/jbc.ra119.010033","journal-title":"J Biol Chem"},{"key":"3684_CR123","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00207-17","author":"GH Kaihami","year":"2017","unstructured":"Kaihami GH, Breda LCD, de Almeida JRF et al (2017) The atypical response regulator AtvR is a new player in Pseudomonas aeruginosa response to hypoxia and virulence. Infect Immun. https:\/\/doi.org\/10.1128\/IAI.00207-17","journal-title":"Infect Immun"},{"key":"3684_CR124","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1016\/j.ijmm.2014.07.014","volume":"304","author":"A Eichner","year":"2014","unstructured":"Eichner A, G\u00fcnther N, Arnold M et al (2014) Marker genes for the metabolic adaptation of Pseudomonas aeruginosa to the hypoxic cystic fibrosis lung environment. Int J Med Microbiol 304:1050\u20131061. https:\/\/doi.org\/10.1016\/j.ijmm.2014.07.014","journal-title":"Int J Med Microbiol"},{"key":"3684_CR125","doi-asserted-by":"crossref","unstructured":"Pfyffer GE (2015) Mycobacterium: general characteristics, laboratory detection, and staining procedures. In: Manual of clinical microbiology. ASM Press, Washington, DC, pp 536\u2013569","DOI":"10.1128\/9781555817381.ch30"},{"key":"3684_CR126","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.mib.2020.05.009","volume":"55","author":"AN King","year":"2020","unstructured":"King AN, de Mets F, Brinsmade SR (2020) Who\u2019s in control? Regulation of metabolism and pathogenesis in space and time. Curr Opin Microbiol 55:88\u201396","journal-title":"Curr Opin Microbiol"},{"key":"3684_CR127","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/s41579-018-0055-7","volume":"16","author":"F Jacob-Dubuisson","year":"2018","unstructured":"Jacob-Dubuisson F, Mechaly A, Betton JM, Antoine R (2018) Structural insights into the signalling mechanisms of two-component systems. Nat Rev Microbiol 16:585\u2013593","journal-title":"Nat Rev Microbiol"},{"key":"3684_CR128","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.mgm2-0010-2013","author":"T Parish","year":"2014","unstructured":"Parish T (2014) Two-component regulatory systems of mycobacteria. Microbiol Spectr. https:\/\/doi.org\/10.1128\/microbiolspec.mgm2-0010-2013","journal-title":"Microbiol Spectr"},{"key":"3684_CR129","doi-asserted-by":"crossref","first-page":"259","DOI":"10.3390\/bios3030259","volume":"3","author":"S Sivaramakrishnan","year":"2013","unstructured":"Sivaramakrishnan S, De Montellano PRO (2013) The DosS-DosT\/DosR mycobacterial sensor system. Biosensors 3:259\u2013282","journal-title":"Biosensors"},{"key":"3684_CR130","doi-asserted-by":"publisher","first-page":"19862","DOI":"10.1074\/jbc.RA119.009449","volume":"294","author":"SK Banerjee","year":"2019","unstructured":"Banerjee SK, Lata S, Sharma AK et al (2019) The sensor kinase MtrB of Mycobacterium tuberculosis regulates hypoxic survival and establishment of infection. J Biol Chem 294:19862\u201319876. https:\/\/doi.org\/10.1074\/jbc.RA119.009449","journal-title":"J Biol Chem"},{"key":"3684_CR131","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41426-018-0032-2","volume":"7","author":"H Yang","year":"2018","unstructured":"Yang H, Sha W, Liu Z et al (2018) Lysine acetylation of DosR regulates the hypoxia response of Mycobacterium tuberculosis article. Emerg Microbes Infect 7:1\u201314. https:\/\/doi.org\/10.1038\/s41426-018-0032-2","journal-title":"Emerg Microbes Infect"},{"key":"3684_CR132","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-49666-0","author":"V Kumar","year":"2019","unstructured":"Kumar V, Aneesh Kumar A, Sanawar R et al (2019) Chronic pressure overload results in deficiency of mitochondrial membrane transporter ABCB7 which contributes to iron overload, mitochondrial dysfunction, metabolic shift and worsens cardiac function. Sci Rep. https:\/\/doi.org\/10.1038\/s41598-019-49666-0","journal-title":"Sci Rep"},{"key":"3684_CR133","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.bbrc.2018.07.123","volume":"503","author":"X Sun","year":"2018","unstructured":"Sun X, Wang Y, Sui N (2018) Transcriptional regulation of bHLH during plant response to stress. Biochem Biophys Res Commun 503:397\u2013401","journal-title":"Biochem Biophys Res Commun"},{"key":"3684_CR134","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1038\/nature12337","volume":"499","author":"JE Galagan","year":"2013","unstructured":"Galagan JE, Minch K, Peterson M et al (2013) The Mycobacterium tuberculosis regulatory network and hypoxia. Nature 499:178\u2013183. https:\/\/doi.org\/10.1038\/nature12337","journal-title":"Nature"},{"key":"3684_CR135","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1099\/jmm.0.000511","volume":"66","author":"C Sun","year":"2017","unstructured":"Sun C, Yang G, Yuan J et al (2017) Mycobacterium tuberculosis hypoxic response protein 1 (Hrp1) augments the pro-inflammatory response and enhances the survival of Mycobacterium smegmatis in murine macrophages. J Med Microbiol 66:1033\u20131044. https:\/\/doi.org\/10.1099\/jmm.0.000511","journal-title":"J Med Microbiol"},{"key":"3684_CR136","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1038\/nchembio.2259","volume":"13","author":"H Zheng","year":"2017","unstructured":"Zheng H, Colvin CJ, Johnson BK et al (2017) Inhibitors of Mycobacterium tuberculosis DosRST signaling and persistence. Nat Chem Biol 13:218\u2013225. https:\/\/doi.org\/10.1038\/nchembio.2259","journal-title":"Nat Chem Biol"},{"key":"3684_CR137","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1021\/acschembio.8b00849","volume":"15","author":"H Zheng","year":"2019","unstructured":"Zheng H, Williams JT, Aleiwi B et al (2019) Inhibiting Mycobacterium tuberculosis DosRST signaling by targeting response regulator DNA binding and sensor kinase heme. ACS Chem Biol 15:52\u201362. https:\/\/doi.org\/10.1021\/acschembio.8b00849","journal-title":"ACS Chem Biol"},{"key":"3684_CR138","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1038\/nature13967","volume":"517","author":"SH Oehlers","year":"2015","unstructured":"Oehlers SH, Cronan MR, Scott NR et al (2015) Interception of host angiogenic signalling limits mycobacterial growth. Nature 517:612\u2013615. https:\/\/doi.org\/10.1038\/nature13967","journal-title":"Nature"},{"key":"3684_CR139","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.mib.2020.01.011","volume":"54","author":"L Ramakrishnan","year":"2020","unstructured":"Ramakrishnan L (2020) Mycobacterium tuberculosis pathogenicity viewed through the lens of molecular Koch\u2019s postulates. Curr Opin Microbiol 54:103\u2013110","journal-title":"Curr Opin Microbiol"},{"key":"3684_CR140","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.mib.2018.11.010","volume":"47","author":"I Hayek","year":"2019","unstructured":"Hayek I, Berens C, L\u00fchrmann A (2019) Modulation of host cell metabolism by T4SS-encoding intracellular pathogens. Curr Opin Microbiol 47:59\u201365","journal-title":"Curr Opin Microbiol"},{"key":"3684_CR141","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.cmet.2019.08.018","volume":"30","author":"J Yuan","year":"2019","unstructured":"Yuan J, Chen C, Cui J et al (2019) Fatty liver disease caused by high-alcohol-producing Klebsiella pneumoniae. Cell Metab 30:675-688.e7. https:\/\/doi.org\/10.1016\/j.cmet.2019.08.018","journal-title":"Cell Metab"},{"key":"3684_CR142","doi-asserted-by":"publisher","first-page":"47","DOI":"10.3389\/fmicb.2016.00047","volume":"7","author":"FMF Elshaghabee","year":"2016","unstructured":"Elshaghabee FMF, Bockelmann W, Meske D et al (2016) Ethanol production by selected intestinal microorganisms and lactic acid bacteria growing under different nutritional conditions. Front Microbiol 7:47. https:\/\/doi.org\/10.3389\/fmicb.2016.00047","journal-title":"Front Microbiol"},{"key":"3684_CR143","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00393-19","author":"AW Crocker","year":"2019","unstructured":"Crocker AW, Harty CE, Hammond JH et al (2019) Pseudomonas aeruginosa ethanol oxidation by AdhA in low-oxygen environments. J Bacteriol. https:\/\/doi.org\/10.1128\/JB.00393-19","journal-title":"J Bacteriol"},{"key":"3684_CR144","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1128\/jb.160.3.928-934.1984","volume":"160","author":"CV Wauven","year":"1984","unstructured":"Wauven CV, Pierard A, Kley-Raymann M, Haas D (1984) Pseudomonas aeruginosa mutants affected in anaerobic growth on arginine: evidence for a four-gene cluster encoding the arginine deiminase pathway. J Bacteriol 160:918\u2013934. https:\/\/doi.org\/10.1128\/jb.160.3.928-934.1984","journal-title":"J Bacteriol"},{"key":"3684_CR145","doi-asserted-by":"publisher","first-page":"4596","DOI":"10.1128\/JB.186.14.4596-4604.2004","volume":"186","author":"M Eschbach","year":"2004","unstructured":"Eschbach M, Schreiber K, Trunk K et al (2004) Long-term anaerobic survival of the opportunistic pathogen Pseudomonas aeruginosa via pyruvate fermentation. J Bacteriol 186:4596\u20134604. https:\/\/doi.org\/10.1128\/JB.186.14.4596-4604.2004","journal-title":"J Bacteriol"},{"key":"3684_CR146","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1111\/1751-7915.12851","volume":"10","author":"JM Borrero-de Acu\u00f1a","year":"2017","unstructured":"Borrero-de Acu\u00f1a JM, Timmis KN, Jahn M, Jahn D (2017) Protein complex formation during denitrification by Pseudomonas aeruginosa. Microb Biotechnol 10:1523\u20131534","journal-title":"Microb Biotechnol"},{"key":"3684_CR147","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2016.00006","author":"CL Sershen","year":"2016","unstructured":"Sershen CL, Plimpton SJ, May EE (2016) Oxygen modulates the effectiveness of granuloma mediated host response to Mycobacterium tuberculosis: a multiscale computational biology approach. Front Cell Infect Microbiol. https:\/\/doi.org\/10.3389\/fcimb.2016.00006","journal-title":"Front Cell Infect Microbiol"},{"key":"3684_CR148","doi-asserted-by":"publisher","first-page":"3258","DOI":"10.1128\/IAI.01449-08","volume":"77","author":"RW Honaker","year":"2009","unstructured":"Honaker RW, Leistikow RL, Bartek IL, Voskui MI (2009) Unique roles of DosT and DosS in DosR regulon induction and Mycobacterium tuberculosis dormancy. Infect Immun 77:3258\u20133263. https:\/\/doi.org\/10.1128\/IAI.01449-08","journal-title":"Infect Immun"},{"key":"3684_CR149","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.02339","author":"K Jakkala","year":"2019","unstructured":"Jakkala K, Ajitkumar P (2019) Hypoxic non-replicating persistent Mycobacterium tuberculosis develops thickened outer layer that helps in restricting rifampicin entry. Front Microbiol. https:\/\/doi.org\/10.3389\/fmicb.2019.02339","journal-title":"Front Microbiol"},{"key":"3684_CR150","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00273-19","author":"A Iacobino","year":"2019","unstructured":"Iacobino A, Giannoni F, Pardini M et al (2019) The combination rifampin-nitazoxanide, but not rifampin-isoniazid-pyrazinamide-ethambutol, kills dormant Mycobacterium tuberculosis in hypoxia at neutral pH. Antimicrob Agents Chemother. https:\/\/doi.org\/10.1128\/AAC.00273-19","journal-title":"Antimicrob Agents Chemother"},{"key":"3684_CR151","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1128\/AAC.05574-11","volume":"56","author":"B Schaible","year":"2012","unstructured":"Schaible B, Taylor CT, Schaffer K (2012) Hypoxia increases antibiotic resistance in Pseudomonas aeruginosa through altering the composition of multidrug efflux pumps. Antimicrob Agents Chemother 56:2114\u20132118. https:\/\/doi.org\/10.1128\/AAC.05574-11","journal-title":"Antimicrob Agents Chemother"},{"key":"3684_CR152","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.01346","author":"P Du","year":"2016","unstructured":"Du P, Sohaskey CD, Shi L (2016) Transcriptional and physiological changes during Mycobacterium tuberculosis reactivation from non-replicating persistence. Front Microbiol. https:\/\/doi.org\/10.3389\/fmicb.2016.01346","journal-title":"Front Microbiol"},{"key":"3684_CR153","doi-asserted-by":"publisher","first-page":"2351","DOI":"10.1074\/jbc.M114.615534","volume":"290","author":"A McGillivray","year":"2015","unstructured":"McGillivray A, Golden NA, Kaushal D (2015) The Mycobacterium tuberculosis Clp gene regulator is required for in vitro reactivation from hypoxia-induced dormancy. J Biol Chem 290:2351\u20132367. https:\/\/doi.org\/10.1074\/jbc.M114.615534","journal-title":"J Biol Chem"},{"key":"3684_CR154","doi-asserted-by":"publisher","DOI":"10.1038\/nmicrobiol.2017.84","author":"H Eoh","year":"2017","unstructured":"Eoh H, Wang Z, Layre E et al (2017) Metabolic anticipation in Mycobacterium tuberculosis. Nat Microbiol. https:\/\/doi.org\/10.1038\/nmicrobiol.2017.84","journal-title":"Nat Microbiol"},{"key":"3684_CR155","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.it.2015.01.003","volume":"36","author":"C Bogdan","year":"2015","unstructured":"Bogdan C (2015) Nitric oxide synthase in innate and adaptive immunity: an update. Trends Immunol 36:161\u2013178","journal-title":"Trends Immunol"},{"key":"3684_CR156","doi-asserted-by":"publisher","first-page":"8841","DOI":"10.1073\/pnas.97.16.8841","volume":"97","author":"C Nathan","year":"2000","unstructured":"Nathan C, Shiloh MU (2000) Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens. Proc Natl Acad Sci USA 97:8841\u20138848. https:\/\/doi.org\/10.1073\/pnas.97.16.8841","journal-title":"Proc Natl Acad Sci USA"},{"key":"3684_CR157","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1042\/0264-6021:3500709","volume":"350","author":"CC McCormick","year":"2000","unstructured":"McCormick CC, Li WP, Calero M (2000) Oxygen tension limits nitric oxide synthesis by activated macrophages. Biochem J 350:709\u2013716. https:\/\/doi.org\/10.1042\/0264-6021:3500709","journal-title":"Biochem J"},{"key":"3684_CR158","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1316894110","author":"A Cunningham-Bussel","year":"2013","unstructured":"Cunningham-Bussel A, Zhang T, Nathan CF (2013) Nitrite produced by Mycobacterium tuberculosis in human macrophages in physiologic oxygen impacts bacterial ATP consumption and gene expression. Proc Natl Acad Sci USA. https:\/\/doi.org\/10.1073\/pnas.1316894110","journal-title":"Proc Natl Acad Sci USA"},{"key":"3684_CR159","doi-asserted-by":"publisher","first-page":"453","DOI":"10.4049\/jimmunol.1002213","volume":"186","author":"NN McGovern","year":"2011","unstructured":"McGovern NN, Cowburn AS, Porter L et al (2011) Hypoxia selectively inhibits respiratory burst activity and killing of staphylococcus aureus in human neutrophils. J Immunol 186:453\u2013463. https:\/\/doi.org\/10.4049\/jimmunol.1002213","journal-title":"J Immunol"},{"key":"3684_CR160","doi-asserted-by":"publisher","first-page":"518","DOI":"10.3389\/fimmu.2016.00518","volume":"7","author":"K Branitzki-Heinemann","year":"2016","unstructured":"Branitzki-Heinemann K, M\u00f6llerherm H, V\u00f6llger L et al (2016) Formation of neutrophil extracellular traps under low oxygen level. Front Immunol 7:518. https:\/\/doi.org\/10.3389\/fimmu.2016.00518","journal-title":"Front Immunol"},{"key":"3684_CR161","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00541","author":"H M\u00f6llerherm","year":"2017","unstructured":"M\u00f6llerherm H, Branitzki-Heinemann K, Brogden G et al (2017) Hypoxia modulates the response of mast cells to Staphylococcus aureus infection. Front Immunol. https:\/\/doi.org\/10.3389\/fimmu.2017.00541","journal-title":"Front Immunol"},{"key":"3684_CR162","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00696-13","author":"TL Kinkel","year":"2013","unstructured":"Kinkel TL, Roux CM, Dunman PM, Fang FC (2013) The Staphylococcus aureus SrrAB two-component system promotes resistance to nitrosative stress and hypoxia. MBio. https:\/\/doi.org\/10.1128\/mBio.00696-13","journal-title":"MBio"},{"key":"3684_CR163","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1164\/arrd.1977.116.4.671","volume":"116","author":"GD Harris","year":"1977","unstructured":"Harris GD, Johanson WG, Pierce AK (1977) Determinants of lung bacterial clearance in mice after acute hypoxia. Am Rev Respir Dis 116:671\u2013677. https:\/\/doi.org\/10.1164\/arrd.1977.116.4.671","journal-title":"Am Rev Respir Dis"},{"key":"3684_CR164","doi-asserted-by":"publisher","first-page":"4001","DOI":"10.4049\/jimmunol.1100976","volume":"188","author":"D Nickel","year":"2012","unstructured":"Nickel D, Busch M, Mayer D et al (2012) Hypoxia triggers the expression of human \u03b2 Defensin 2 and antimicrobial activity against Mycobacterium tuberculosis in human macrophages. J Immunol 188:4001\u20134007. https:\/\/doi.org\/10.4049\/jimmunol.1100976","journal-title":"J Immunol"},{"key":"3684_CR165","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1007\/s00430-015-0442-x","volume":"205","author":"SF Zenk","year":"2016","unstructured":"Zenk SF, Vollmer M, Schercher E et al (2016) Hypoxia promotes Mycobacterium tuberculosis-specific up-regulation of granulysin in human T cells. Med Microbiol Immunol 205:219\u2013229. https:\/\/doi.org\/10.1007\/s00430-015-0442-x","journal-title":"Med Microbiol Immunol"},{"key":"3684_CR166","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1111\/febs.13270","volume":"282","author":"K Schaffer","year":"2015","unstructured":"Schaffer K, Taylor CT (2015) The impact of hypoxia on bacterial infection. FEBS J 282:2260\u20132266","journal-title":"FEBS J"},{"key":"3684_CR167","doi-asserted-by":"publisher","first-page":"e00543","DOI":"10.1128\/IAI.00543-18","volume":"86","author":"ML Gil-Marqu\u00e9s","year":"2018","unstructured":"Gil-Marqu\u00e9s ML, Pach\u00f3n-Ib\u00e1\u00f1ez ME, Pach\u00f3n J, Smani Y (2018) Effect of hypoxia on the pathogenesis of Acinetobacter baumannii and Pseudomonas aeruginosa in vitro and in murine experimental models of infection. Infect Immun 86:e00543-e618. https:\/\/doi.org\/10.1128\/IAI.00543-18","journal-title":"Infect Immun"},{"key":"3684_CR168","doi-asserted-by":"publisher","first-page":"e1003457","DOI":"10.1371\/journal.ppat.1003457","volume":"9","author":"EA Berger","year":"2013","unstructured":"Berger EA, McClellan SA, Vistisen KS, Hazlett LD (2013) HIF-1\u03b1 is essential for effective PMN bacterial killing, antimicrobial peptide production and apoptosis in Pseudomonas aeruginosa keratitis. PLoS Pathog 9:e1003457. https:\/\/doi.org\/10.1371\/journal.ppat.1003457","journal-title":"PLoS Pathog"},{"key":"3684_CR169","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/j.chom.2013.03.003","volume":"13","author":"NV Kirienko","year":"2013","unstructured":"Kirienko NV, Kirienko DR, Larkins-Ford J et al (2013) Pseudomonas aeruginosa disrupts Caenorhabditis elegans iron homeostasis, causing a hypoxic response and death. Cell Host Microbe 13:406\u2013416. https:\/\/doi.org\/10.1016\/j.chom.2013.03.003","journal-title":"Cell Host Microbe"},{"key":"3684_CR170","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1128\/iai.64.2.518-523.1996","volume":"64","author":"JM Meyer","year":"1996","unstructured":"Meyer JM, Neely A, Stintzi A et al (1996) Pyoverdin is essential for virulence of Pseudomonas aeruginosa. Infect Immun 64:518\u2013523. https:\/\/doi.org\/10.1128\/iai.64.2.518-523.1996","journal-title":"Infect Immun"},{"key":"3684_CR171","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1093\/intimm\/dxz048","volume":"31","author":"M Osada-Oka","year":"2019","unstructured":"Osada-Oka M, Goda N, Saiga H et al (2019) Metabolic adaptation to glycolysis is a basic defense mechanism of macrophages for Mycobacterium tuberculosis infection. Int Immunol 31:781\u2013793. https:\/\/doi.org\/10.1093\/intimm\/dxz048","journal-title":"Int Immunol"},{"key":"3684_CR172","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1042\/BJ20111275","volume":"438","author":"V Infantino","year":"2011","unstructured":"Infantino V, Convertini P, Cucci L et al (2011) The mitochondrial citrate carrier: a new player in inflammation. Biochem J 438:433\u2013436. https:\/\/doi.org\/10.1042\/BJ20111275","journal-title":"Biochem J"},{"key":"3684_CR173","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1016\/j.bbagrm.2014.07.013","volume":"1839","author":"V Infantino","year":"2014","unstructured":"Infantino V, Iacobazzi V, Menga A et al (2014) A key role of the mitochondrial citrate carrier (SLC25A1) in TNF\u03b1- and IFN\u03b3-triggered inflammation. Biochim Biophys Acta Gene Regul Mech 1839:1217\u20131225. https:\/\/doi.org\/10.1016\/j.bbagrm.2014.07.013","journal-title":"Biochim Biophys Acta Gene Regul Mech"},{"key":"3684_CR174","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.celrep.2015.05.046","volume":"12","author":"JS Moon","year":"2015","unstructured":"Moon JS, Hisata S, Park MA et al (2015) MTORC1-induced HK1-dependent glycolysis regulates NLRP3 inflammasome activation. Cell Rep 12:102\u2013115. https:\/\/doi.org\/10.1016\/j.celrep.2015.05.046","journal-title":"Cell Rep"},{"key":"3684_CR175","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/j.chom.2018.04.002","volume":"23","author":"M Rother","year":"2018","unstructured":"Rother M, Gonzalez E, Teixeira da Costa AR et al (2018) Combined human genome-wide RNAi and metabolite analyses identify IMPDH as a host-directed target against chlamydia infection. Cell Host Microbe 23:661-671.e8. https:\/\/doi.org\/10.1016\/j.chom.2018.04.002","journal-title":"Cell Host Microbe"},{"key":"3684_CR176","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1111\/imm.13131","volume":"159","author":"M Resende","year":"2020","unstructured":"Resende M, Ferreira CM, Barbosa AM et al (2020) Myeloid HIF-1\u03b1 regulates pulmonary inflammation during experimental Mycobacterium tuberculosis infection. Immunology 159:121\u2013129. https:\/\/doi.org\/10.1111\/imm.13131","journal-title":"Immunology"},{"key":"3684_CR177","doi-asserted-by":"publisher","first-page":"494","DOI":"10.4049\/jimmunol.1801139","volume":"202","author":"NV Ogryzko","year":"2019","unstructured":"Ogryzko NV, Lewis A, Wilson HL et al (2019) Hif-1\u03b1\u2013induced expression of Il-1\u03b2 protects against Mycobacterial infection in zebrafish. J Immunol 202:494\u2013502. https:\/\/doi.org\/10.4049\/jimmunol.1801139","journal-title":"J Immunol"},{"key":"3684_CR178","doi-asserted-by":"publisher","first-page":"270","DOI":"10.4049\/jimmunol.1200061","volume":"190","author":"AM Green","year":"2013","unstructured":"Green AM, DiFazio R, Flynn JL (2013) IFN-\u03b3 from CD4 T cells is essential for host survival and enhances CD8 T cell function during Mycobacterium tuberculosis infection. J Immunol 190:270\u2013277. https:\/\/doi.org\/10.4049\/jimmunol.1200061","journal-title":"J Immunol"},{"key":"3684_CR179","doi-asserted-by":"crossref","first-page":"4408","DOI":"10.4049\/jimmunol.138.12.4408","volume":"138","author":"I Flesch","year":"1987","unstructured":"Flesch I, Kaufmann SH (1987) Mycobacterial growth inhibition by interferon-gamma-activated bone marrow macrophages and differential susceptibility among strains of Mycobacterium tuberculosis. J Immunol 138:4408\u20134413","journal-title":"J Immunol"},{"key":"3684_CR180","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1016\/j.imbio.2007.09.018","volume":"212","author":"AR Shenoy","year":"2008","unstructured":"Shenoy AR, Kim BH, Choi HP et al (2008) Emerging themes in IFN-\u03b3-induced macrophage immunity by the p47 and p65 GTPase families. Immunobiology 212:771\u2013784. https:\/\/doi.org\/10.1016\/j.imbio.2007.09.018","journal-title":"Immunobiology"},{"key":"3684_CR181","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.4049\/jimmunol.1600266","volume":"197","author":"J Braverman","year":"2016","unstructured":"Braverman J, Sogi KM, Benjamin D et al (2016) HIF-1\u03b1 is an essential mediator of IFN-\u03b3\u2013dependent immunity to Mycobacterium tuberculosis. J Immunol 197:1287\u20131297. https:\/\/doi.org\/10.4049\/jimmunol.1600266","journal-title":"J Immunol"},{"key":"3684_CR182","doi-asserted-by":"publisher","first-page":"11572","DOI":"10.18632\/oncotarget.24098","volume":"9","author":"X Song","year":"2018","unstructured":"Song X, Zhang Y, Zhang L et al (2018) Hypoxia enhances indoleamine 2,3-dioxygenase production in dendritic cells. Oncotarget 9:11572\u201311580. https:\/\/doi.org\/10.18632\/oncotarget.24098","journal-title":"Oncotarget"},{"key":"3684_CR183","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1093\/intimm\/dxh140","volume":"16","author":"AL Mellor","year":"2004","unstructured":"Mellor AL, Chandler P, Baban B et al (2004) Specific subsets of murine dendritic cells acquire potent T cell regulatory functions following CTLA4-mediated induction of indoleamine 2,3 dioxygenase. Int Immunol 16:1391\u20131401. https:\/\/doi.org\/10.1093\/intimm\/dxh140","journal-title":"Int Immunol"},{"key":"3684_CR184","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1073\/pnas.81.3.908","volume":"81","author":"ER Pfefferkorn","year":"1984","unstructured":"Pfefferkorn ER (1984) Interferon \u03b3 blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan. Proc Natl Acad Sci USA 81:908\u2013912. https:\/\/doi.org\/10.1073\/pnas.81.3.908","journal-title":"Proc Natl Acad Sci USA"},{"key":"3684_CR185","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1128\/iai.53.2.347-351.1986","volume":"53","author":"GI Byrne","year":"1986","unstructured":"Byrne GI, Lehmann LK, Landry GJ (1986) Induction of tryptophan catabolism is the mechanism for gamma-interferon-mediated inhibition of intracellular Chlamydia psittaci replication in T24 cells. Infect Immun 53:347\u2013351. https:\/\/doi.org\/10.1128\/iai.53.2.347-351.1986","journal-title":"Infect Immun"},{"key":"3684_CR186","doi-asserted-by":"publisher","first-page":"e1007955","DOI":"10.1371\/journal.ppat.1007955","volume":"15","author":"S Ganesan","year":"2019","unstructured":"Ganesan S, Roy CR (2019) Host cell depletion of tryptophan by IFN\u03b3-induced Indoleamine 2,3-dioxygenase 1 (IDO1) inhibits lysosomal replication of Coxiella burnetii. PLoS Pathog 15:e1007955. https:\/\/doi.org\/10.1371\/journal.ppat.1007955","journal-title":"PLoS Pathog"},{"key":"3684_CR187","doi-asserted-by":"publisher","first-page":"19502","DOI":"10.1073\/pnas.1008178107","volume":"107","author":"A Roth","year":"2010","unstructured":"Roth A, K\u00f6nig P, Zandbergen VG et al (2010) Hypoxia abrogates antichlamydial properties of IFN-\u03b3 in human fallopian tube cells in vitro and ex vivo. Proc Natl Acad Sci U S A 107:19502\u201319507. https:\/\/doi.org\/10.1073\/pnas.1008178107","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3684_CR188","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1189\/jlb.0307195","volume":"82","author":"RJ Anand","year":"2007","unstructured":"Anand RJ, Gribar SC, Li J et al (2007) Hypoxia causes an increase in phagocytosis by macrophages in a HIF-1\u03b1-dependent manner. J Leukoc Biol 82:1257\u20131265. https:\/\/doi.org\/10.1189\/jlb.0307195","journal-title":"J Leukoc Biol"},{"key":"3684_CR189","doi-asserted-by":"publisher","first-page":"2570","DOI":"10.1128\/mcb.00166-09","volume":"29","author":"G Bellot","year":"2009","unstructured":"Bellot G, Garcia-Medina R, Gounon P et al (2009) Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains. Mol Cell Biol 29:2570\u20132581. https:\/\/doi.org\/10.1128\/mcb.00166-09","journal-title":"Mol Cell Biol"},{"key":"3684_CR190","doi-asserted-by":"publisher","first-page":"2333","DOI":"10.4161\/15548627.2014.984275","volume":"10","author":"S Mimouna","year":"2014","unstructured":"Mimouna S, Bazin M, Mograbi B et al (2014) HIF1A regulates xenophagic degradation of adherent and invasive Escherichia coli (AIEC). Autophagy 10:2333\u20132345. https:\/\/doi.org\/10.4161\/15548627.2014.984275","journal-title":"Autophagy"},{"key":"3684_CR191","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.240440","author":"Y Cong","year":"2020","unstructured":"Cong Y, Kumar ND, Mauthe M et al (2020) Manipulation of selective macroautophagy by pathogens at a glance. J Cell Sci. https:\/\/doi.org\/10.1242\/jcs.240440","journal-title":"J Cell Sci"},{"key":"3684_CR192","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1038\/s41418-019-0481-8","volume":"27","author":"MD Keller","year":"2020","unstructured":"Keller MD, Torres VJ, Cadwell K (2020) Autophagy and microbial pathogenesis. Cell Death Differ 27:872\u2013886","journal-title":"Cell Death Differ"},{"key":"3684_CR193","doi-asserted-by":"publisher","first-page":"1899","DOI":"10.1080\/15548627.2019.1596483","volume":"15","author":"P Neubert","year":"2019","unstructured":"Neubert P, Weichselbaum A, Reitinger C et al (2019) HIF1A and NFAT5 coordinate Na+-boosted antibacterial defense via enhanced autophagy and autolysosomal targeting. Autophagy 15:1899\u20131916. https:\/\/doi.org\/10.1080\/15548627.2019.1596483","journal-title":"Autophagy"},{"key":"3684_CR194","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00125-19","author":"D Friedrich","year":"2019","unstructured":"Friedrich D, Zapf D, Lohse B et al (2019) The HIF-1\/LC3-II axis impacts fungal immunity in human macrophages. Infect Immun. https:\/\/doi.org\/10.1128\/IAI.00125-19","journal-title":"Infect Immun"},{"key":"3684_CR195","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/JLB.3MIR1118-415R","volume":"106","author":"NK Patil","year":"2019","unstructured":"Patil NK, Bohannon JK, Hernandez A et al (2019) Regulation of leukocyte function by citric acid cycle intermediates. J Leukoc Biol 106:105\u2013117","journal-title":"J Leukoc Biol"},{"key":"3684_CR196","doi-asserted-by":"publisher","first-page":"e1005408","DOI":"10.1371\/journal.ppat.1005408","volume":"12","author":"J Naujoks","year":"2016","unstructured":"Naujoks J, Tabeling C, Dill BD et al (2016) IFNs modify the proteome of legionella-containing vacuoles and restrict infection via IRG1-derived itaconic acid. PLoS Pathog 12:e1005408. https:\/\/doi.org\/10.1371\/journal.ppat.1005408","journal-title":"PLoS Pathog"},{"key":"3684_CR197","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1126\/science.aaz1333","volume":"369","author":"M Chen","year":"2020","unstructured":"Chen M, Sun H, Boot M et al (2020) Itaconate is an effector of a Rab GTPase cell-autonomous host defense pathway against Salmonella. Science (80-) 369:450\u2013455. https:\/\/doi.org\/10.1126\/science.aaz1333","journal-title":"Science (80-)"},{"key":"3684_CR198","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1146\/annurev-nutr-071714-034243","volume":"35","author":"T Cordes","year":"2015","unstructured":"Cordes T, Michelucci A, Hiller K (2015) Itaconic acid: the surprising role of an industrial compound as a mammalian antimicrobial metabolite. Annu Rev Nutr 35:451\u2013473. https:\/\/doi.org\/10.1146\/annurev-nutr-071714-034243","journal-title":"Annu Rev Nutr"},{"key":"3684_CR199","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1038\/nchembio.1482","volume":"10","author":"J Sasikaran","year":"2014","unstructured":"Sasikaran J, Ziemski M, Zadora PK et al (2014) Bacterial itaconate degradation promotes pathogenicity. Nat Chem Biol 10:371\u2013377. https:\/\/doi.org\/10.1038\/nchembio.1482","journal-title":"Nat Chem Biol"},{"key":"3684_CR200","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s40121-014-0030-1","volume":"3","author":"T Bhandari","year":"2014","unstructured":"Bhandari T, Nizet V (2014) Hypoxia-inducible factor (HIF) as a pharmacological target for prevention and treatment of infectious diseases. Infect Dis Ther 3:159\u2013174","journal-title":"Infect Dis Ther"},{"key":"3684_CR201","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1038\/nrneph.2015.193","volume":"12","author":"PH Maxwell","year":"2016","unstructured":"Maxwell PH, Eckardt KU (2016) HIF prolyl hydroxylase inhibitors for the treatment of renal anaemia and beyond. Nat Rev Nephrol 12:157\u2013168. https:\/\/doi.org\/10.1038\/nrneph.2015.193","journal-title":"Nat Rev Nephrol"},{"key":"3684_CR202","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-100819-121537","author":"SP Colgan","year":"2020","unstructured":"Colgan SP, Furuta GT, Taylor CT (2020) Hypoxia and innate immunity: keeping up with the HIFsters. Annu Rev Immunol. https:\/\/doi.org\/10.1146\/annurev-immunol-100819-121537","journal-title":"Annu Rev Immunol"},{"key":"3684_CR203","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1086\/524843","volume":"197","author":"AS Zinkernagel","year":"2008","unstructured":"Zinkernagel AS, Peyssonnaux C, Johnson RS, Nizet V (2008) Pharmacologic augmentation of hypoxia-inducible factor\u20131\u03b1 with mimosine boosts the bactericidal capacity of phagocytes. J Infect Dis 197:214\u2013217. https:\/\/doi.org\/10.1086\/524843","journal-title":"J Infect Dis"},{"key":"3684_CR204","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1007\/s00109-012-0882-3","volume":"90","author":"CYM Okumura","year":"2012","unstructured":"Okumura CYM, Hollands A, Tran DN et al (2012) A new pharmacological agent (AKB-4924) stabilizes hypoxia inducible factor-1 (HIF-1) and increases skin innate defenses against bacterial infection. J Mol Med 90:1079\u20131089. https:\/\/doi.org\/10.1007\/s00109-012-0882-3","journal-title":"J Mol Med"},{"key":"3684_CR205","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004818","author":"AE Lin","year":"2015","unstructured":"Lin AE, Beasley FC, Olson J et al (2015) Role of hypoxia inducible factor-1\u03b1 (HIF-1\u03b1) in innate defense against uropathogenic Escherichia coli infection. PLoS Pathog. https:\/\/doi.org\/10.1371\/journal.ppat.1004818","journal-title":"PLoS Pathog"},{"key":"3684_CR206","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1038\/mi.2013.29","volume":"7","author":"S Keely","year":"2014","unstructured":"Keely S, Campbell EL, Baird AW et al (2014) Contribution of epithelial innate immunity to systemic protection afforded by prolyl hydroxylase inhibition in murine colitis. Mucosal Immunol 7:114\u2013123. https:\/\/doi.org\/10.1038\/mi.2013.29","journal-title":"Mucosal Immunol"},{"key":"3684_CR207","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1053\/j.gastro.2007.10.012","volume":"134","author":"EP Cummins","year":"2008","unstructured":"Cummins EP, Seeballuck F, Keely SJ et al (2008) The hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitis. Gastroenterology 134:156-165.e1. https:\/\/doi.org\/10.1053\/j.gastro.2007.10.012","journal-title":"Gastroenterology"},{"key":"3684_CR208","doi-asserted-by":"publisher","first-page":"e56491","DOI":"10.1371\/journal.pone.0056491","volume":"8","author":"B Schaible","year":"2013","unstructured":"Schaible B, McClean S, Selfridge A et al (2013) Hypoxia modulates infection of epithelial cells by Pseudomonas aeruginosa. PLoS ONE 8:e56491. https:\/\/doi.org\/10.1371\/journal.pone.0056491","journal-title":"PLoS ONE"},{"key":"3684_CR209","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1126\/science.1059796","volume":"292","author":"P Jaakkola","year":"2001","unstructured":"Jaakkola P, Mole DR, Tian YM et al (2001) Targeting of HIF-\u03b1 to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science (80-) 292:468\u2013472. https:\/\/doi.org\/10.1126\/science.1059796","journal-title":"Science (80-)"},{"key":"3684_CR210","doi-asserted-by":"publisher","first-page":"836","DOI":"10.3389\/fimmu.2020.00836","volume":"11","author":"JJ Phelan","year":"2020","unstructured":"Phelan JJ, McQuaid K, Kenny C et al (2020) Desferrioxamine supports metabolic function in primary human macrophages infected with Mycobacterium tuberculosis. Front Immunol 11:836. https:\/\/doi.org\/10.3389\/fimmu.2020.00836","journal-title":"Front Immunol"},{"key":"3684_CR211","volume-title":"Deferoxamine. StatPearls [Internet]","author":"J Velasquez","year":"2020","unstructured":"Velasquez J, Wray AA (2020) Deferoxamine. StatPearls [Internet]. StatPearls Publishing, Treasure Island, FL"},{"key":"3684_CR212","doi-asserted-by":"publisher","first-page":"785","DOI":"10.2217\/fmb-2017-0168","volume":"13","author":"GJ Baay-Guzman","year":"2018","unstructured":"Baay-Guzman GJ, Duran-Padilla MA, Rangel-Santiago J et al (2018) Dual role of hypoxia-inducible factor 1 \u03b1 in experimental pulmonary tuberculosis: Its implication as a new therapeutic target. Future Microbiol 13:785\u2013798. https:\/\/doi.org\/10.2217\/fmb-2017-0168","journal-title":"Future Microbiol"},{"key":"3684_CR213","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3389\/fcimb.2019.00042","volume":"9","author":"W Eisenreich","year":"2019","unstructured":"Eisenreich W, Rudel T, Heesemann J, Goebel W (2019) How viral and intracellular bacterial pathogens reprogram the metabolism of host cells to allow their intracellular replication. Front Cell Infect Microbiol 9:42","journal-title":"Front Cell Infect Microbiol"},{"key":"3684_CR214","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1128\/IAI.05972-11","volume":"80","author":"M Wiese","year":"2012","unstructured":"Wiese M, Gerlach RG, Popp I et al (2012) Hypoxia-mediated impairment of the mitochondrial respiratory chain inhibits the bactericidal activity of macrophages. Infect Immun 80:1455\u20131466. https:\/\/doi.org\/10.1128\/IAI.05972-11","journal-title":"Infect Immun"},{"key":"3684_CR215","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1038\/ni.3509","volume":"17","author":"J Garaude","year":"2016","unstructured":"Garaude J, Ac\u00edn-P\u00e9rez R, Mart\u00ednez-Cano S et al (2016) Mitochondrial respiratory-chain adaptations in macrophages contribute to antibacterial host defense. Nat Immunol 17:1037\u20131045. https:\/\/doi.org\/10.1038\/ni.3509","journal-title":"Nat Immunol"},{"key":"3684_CR216","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1038\/nature09973","volume":"472","author":"AP West","year":"2011","unstructured":"West AP, Brodsky IE, Rahner C et al (2011) TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. Nature 472:476\u2013480. https:\/\/doi.org\/10.1038\/nature09973","journal-title":"Nature"},{"key":"3684_CR217","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02092-0","author":"LC Davies","year":"2017","unstructured":"Davies LC, Rice CM, Palmieri EM et al (2017) Peritoneal tissue-resident macrophages are metabolically poised to engage microbes using tissue-niche fuels. Nat Commun. https:\/\/doi.org\/10.1038\/s41467-017-02092-0","journal-title":"Nat Commun"},{"key":"3684_CR218","doi-asserted-by":"crossref","first-page":"7116","DOI":"10.1128\/AEM.02636-13","volume":"79","author":"TK Wood","year":"2013","unstructured":"Wood TK, Knabel SJ, Kwan BW (2013) Bacterial persister cell formation and dormancy. Appl Environ Microbiol 79:7116\u20137121","journal-title":"Appl Environ Microbiol"},{"key":"3684_CR219","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf4268","author":"A Harms","year":"2016","unstructured":"Harms A, Maisonneuve E, Gerdes K (2016) Mechanisms of bacterial persistence during stress and antibiotic exposure. Science (80-). https:\/\/doi.org\/10.1126\/science.aaf4268","journal-title":"Science (80-)"},{"key":"3684_CR220","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.ijmm.2013.03.005","volume":"303","author":"M Szasz\u00e1k","year":"2013","unstructured":"Szasz\u00e1k M, Shima K, K\u00e4ding N et al (2013) Host metabolism promotes growth of Chlamydia pneumoniae in a low oxygen environment. Int J Med Microbiol 303:239\u2013246. https:\/\/doi.org\/10.1016\/j.ijmm.2013.03.005","journal-title":"Int J Med Microbiol"}],"container-title":["Cellular and Molecular Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-020-03684-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00018-020-03684-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-020-03684-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T23:22:30Z","timestamp":1696980150000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00018-020-03684-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,30]]},"references-count":220,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["3684"],"URL":"https:\/\/doi.org\/10.1007\/s00018-020-03684-8","relation":{},"ISSN":["1420-682X","1420-9071"],"issn-type":[{"value":"1420-682X","type":"print"},{"value":"1420-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,30]]},"assertion":[{"value":"8 February 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 October 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}