{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T04:53:33Z","timestamp":1789102413812,"version":"build-2803163510"},"reference-count":275,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T00:00:00Z","timestamp":1613606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T00:00:00Z","timestamp":1613606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001381","name":"National Research Foundation Singapore","doi-asserted-by":"crossref","award":["NRF-CRP17-2017-02"],"award-info":[{"award-number":["NRF-CRP17-2017-02"]}],"id":[{"id":"10.13039\/501100001381","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell. Mol. Life Sci."],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Reactivation of telomerase is a major hallmark observed in 90% of all cancers. Yet paradoxically, enhanced telomerase activity does not correlate with telomere length and cancers often possess short telomeres; suggestive of supplementary non-canonical roles that telomerase might play in the development of cancer. Moreover, studies have shown that aberrant expression of shelterin proteins coupled with their release from shortening telomeres can further promote cancer by mechanisms independent of their telomeric role. While targeting telomerase activity appears to be an attractive therapeutic option, this approach has failed in clinical trials due to undesirable cytotoxic effects on stem cells. To circumvent this concern, an alternative strategy could be to target the molecules involved in the non-canonical functions of telomeric proteins. In this review, we will focus on emerging evidence that has demonstrated the non-canonical roles of telomeric proteins and their impact on tumorigenesis. Furthermore, we aim to address current knowledge gaps in telomeric protein functions and propose future research approaches that can be undertaken to achieve this.<\/jats:p>","DOI":"10.1007\/s00018-021-03783-0","type":"journal-article","created":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T04:45:51Z","timestamp":1613709951000},"page":"4235-4257","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Non-canonical roles of canonical telomere binding proteins in cancers"],"prefix":"10.1007","volume":"78","author":[{"given":"Semih Can","family":"Akincilar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire Hian Tzer","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin Feng","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9910-1068","authenticated-orcid":false,"given":"Kerem","family":"Fidan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinay","family":"Tergaonkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,18]]},"reference":[{"issue":"18","key":"3783_CR1","doi-asserted-by":"publisher","first-page":"6622","DOI":"10.1073\/pnas.85.18.6622","volume":"85","author":"RK Moyzis","year":"1988","unstructured":"Moyzis RK et al (1988) A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes. Proc Natl Acad Sci U S A 85(18):6622\u20136626","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"3783_CR2","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1038\/79594","volume":"7","author":"EH Blackburn","year":"2000","unstructured":"Blackburn EH (2000) The end of the (DNA) line. Nat Struct Biol 7(10):847\u2013850","journal-title":"Nat Struct Biol"},{"issue":"7","key":"3783_CR3","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/S0968-0004(02)02110-2","volume":"27","author":"T von Zglinicki","year":"2002","unstructured":"von Zglinicki T (2002) Oxidative stress shortens telomeres. Trends Biochem Sci 27(7):339\u2013344","journal-title":"Trends Biochem Sci"},{"issue":"6","key":"3783_CR4","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1016\/0092-8674(87)90576-9","volume":"51","author":"CW Greider","year":"1987","unstructured":"Greider CW, Blackburn EH (1987) The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity. Cell 51(6):887\u2013898","journal-title":"Cell"},{"issue":"26","key":"3783_CR5","doi-asserted-by":"publisher","first-page":"19719","DOI":"10.1074\/jbc.M002843200","volume":"275","author":"KE Huffman","year":"2000","unstructured":"Huffman KE et al (2000) Telomere shortening is proportional to the size of the G-rich telomeric 3\u2019-overhang. J Biol Chem 275(26):19719\u201319722","journal-title":"J Biol Chem"},{"issue":"6088","key":"3783_CR6","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1126\/science.1223785","volume":"336","author":"CW Greider","year":"2012","unstructured":"Greider CW (2012) Molecular biology. Wnt regulates TERT\u2013putting the horse before the cart. Science 336(6088):1519\u20131520","journal-title":"Science"},{"issue":"18","key":"3783_CR7","doi-asserted-by":"publisher","first-page":"2100","DOI":"10.1101\/gad.1346005","volume":"19","author":"T de Lange","year":"2005","unstructured":"de Lange T (2005) Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev 19(18):2100\u20132110","journal-title":"Genes Dev"},{"issue":"3","key":"3783_CR8","first-page":"987","volume":"6","author":"SY Rha","year":"2000","unstructured":"Rha SY et al (2000) Effect of telomere and telomerase interactive agents on human tumor and normal cell lines. Clin Cancer Res 6(3):987\u2013993","journal-title":"Clin Cancer Res"},{"issue":"3","key":"3783_CR9","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/S0092-8674(04)00334-4","volume":"117","author":"MT Teixeira","year":"2004","unstructured":"Teixeira MT et al (2004) Telomere length homeostasis is achieved via a switch between telomerase- extendible and -nonextendible states. Cell 117(3):323\u2013335","journal-title":"Cell"},{"issue":"5","key":"3783_CR10","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1016\/j.cell.2016.07.033","volume":"166","author":"JC Schmidt","year":"2016","unstructured":"Schmidt JC, Zaug AJ (2016) Cech, TR live cell imaging reveals the dynamics of telomerase recruitment to telomeres. Cell 166(5):1188\u20131197","journal-title":"Cell"},{"issue":"3","key":"3783_CR11","doi-asserted-by":"publisher","first-page":"160338","DOI":"10.1098\/rsob.160338","volume":"7","author":"CA Armstrong","year":"2017","unstructured":"Armstrong CA, Tomita K (2017) Fundamental mechanisms of telomerase action in yeasts and mammals: understanding telomeres and telomerase in cancer cells. Open Biol 7(3):160338","journal-title":"Open Biol"},{"issue":"36","key":"3783_CR12","doi-asserted-by":"publisher","first-page":"5811","DOI":"10.1038\/s41388-020-01405-w","volume":"39","author":"AN Guterres","year":"2020","unstructured":"Guterres AN, Villanueva J (2020) Targeting telomerase for cancer therapy. Oncogene 39(36):5811\u20135824","journal-title":"Oncogene"},{"issue":"10","key":"3783_CR13","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1080\/15476286.2015.1081329","volume":"12","author":"P Rousseau","year":"2015","unstructured":"Rousseau P, Autexier C (2015) Telomere biology: Rationale for diagnostics and therapeutics in cancer. RNA Biol 12(10):1078\u20131082","journal-title":"RNA Biol"},{"issue":"6","key":"3783_CR14","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1158\/2159-8290.CD-16-0062","volume":"6","author":"JW Shay","year":"2016","unstructured":"Shay JW (2016) Role of telomeres and telomerase in aging and cancer. Cancer Discov 6(6):584\u2013593","journal-title":"Cancer Discov"},{"issue":"7","key":"3783_CR15","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.3390\/cancers12071901","volume":"12","author":"SG Fernandes","year":"2020","unstructured":"Fernandes SG et al (2020) Role of telomeres and telomeric proteins in human malignancies and their therapeutic potential. Cancers (Basel) 12(7):1901","journal-title":"Cancers (Basel)"},{"issue":"6205","key":"3783_CR16","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1038\/337331a0","volume":"337","author":"CW Greider","year":"1989","unstructured":"Greider CW, Blackburn EH (1989) A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis. Nature 337(6205):331\u2013337","journal-title":"Nature"},{"issue":"6262","key":"3783_CR17","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1038\/344126a0","volume":"344","author":"GL Yu","year":"1990","unstructured":"Yu GL et al (1990) In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs. Nature 344(6262):126\u2013132","journal-title":"Nature"},{"issue":"1","key":"3783_CR18","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.molmed.2017.11.003","volume":"24","author":"CL Chew","year":"2018","unstructured":"Chew CL et al (2018) Noncoding RNAs: master regulators of inflammatory signaling. Trends Mol Med 24(1):66\u201384","journal-title":"Trends Mol Med"},{"issue":"4","key":"3783_CR19","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1038\/ng1297-498","volume":"17","author":"SL Weinrich","year":"1997","unstructured":"Weinrich SL et al (1997) Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT. Nat Genet 17(4):498\u2013502","journal-title":"Nat Genet"},{"issue":"5820","key":"3783_CR20","doi-asserted-by":"publisher","first-page":"1850","DOI":"10.1126\/science.1138596","volume":"315","author":"SB Cohen","year":"2007","unstructured":"Cohen SB et al (2007) Protein composition of catalytically active human telomerase from immortal cells. Science 315(5820):1850\u20131853","journal-title":"Science"},{"issue":"7704","key":"3783_CR21","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1038\/s41586-018-0062-x","volume":"557","author":"THD Nguyen","year":"2018","unstructured":"Nguyen THD et al (2018) Cryo-EM structure of substrate-bound human telomerase holoenzyme. Nature 557(7704):190\u2013195","journal-title":"Nature"},{"issue":"5","key":"3783_CR22","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1083\/jcb.200310138","volume":"164","author":"BTE J\u00e1dy","year":"2004","unstructured":"J\u00e1dy BTE, Bertrand E (2004) Kiss TS Human telomerase RNA and box H\/ACA scaRNAs share a common Cajal body\u2013specific localization signal. J Cell Biol 164(5):647\u2013652","journal-title":"J Cell Biol"},{"issue":"5914","key":"3783_CR23","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1126\/science.1165357","volume":"323","author":"AS Venteicher","year":"2009","unstructured":"Venteicher AS et al (2009) A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis. Science 323(5914):644\u2013648","journal-title":"Science"},{"issue":"1","key":"3783_CR24","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1128\/MCB.19.1.567","volume":"19","author":"JR Mitchell","year":"1999","unstructured":"Mitchell JR, Cheng J, Collins K (1999) A box H\/ACA small nucleolar RNA-like domain at the human telomerase RNA 3\u2019 end. Mol Cell Biol 19(1):567\u2013576","journal-title":"Mol Cell Biol"},{"issue":"7","key":"3783_CR25","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1038\/nrm1961","volume":"7","author":"K Collins","year":"2006","unstructured":"Collins K (2006) The biogenesis and regulation of telomerase holoenzymes. Nat Rev Mol Cell Biol 7(7):484\u2013494","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"2","key":"3783_CR26","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1083\/jcb.200601105","volume":"173","author":"X Darzacq","year":"2006","unstructured":"Darzacq X et al (2006) Stepwise RNP assembly at the site of H\/ACA RNA transcription in human cells. J Cell Biol 173(2):207\u2013218","journal-title":"J Cell Biol"},{"issue":"12","key":"3783_CR27","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.cancergen.2011.11.002","volume":"204","author":"PJ Mason","year":"2011","unstructured":"Mason PJ, Bessler M (2011) The genetics of dyskeratosis congenita. Cancer Genet 204(12):635\u2013645","journal-title":"Cancer Genet"},{"issue":"6","key":"3783_CR28","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1261\/rna.1532109","volume":"15","author":"PN Grozdanov","year":"2009","unstructured":"Grozdanov PN et al (2009) SHQ1 is required prior to NAF1 for assembly of H\/ACA small nucleolar and telomerase RNPs. RNA 15(6):1188\u20131197","journal-title":"RNA"},{"issue":"6","key":"3783_CR29","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1016\/j.cell.2008.01.019","volume":"132","author":"AS Venteicher","year":"2008","unstructured":"Venteicher AS et al (2008) Identification of ATPases pontin and reptin as telomerase components essential for holoenzyme assembly. Cell 132(6):945\u2013957","journal-title":"Cell"},{"issue":"10","key":"3783_CR30","doi-asserted-by":"publisher","first-page":"1833","DOI":"10.1261\/rna.034942.112","volume":"18","author":"R Machado-Pinilla","year":"2012","unstructured":"Machado-Pinilla R et al (2012) Mechanism of the AAA+ ATPases pontin and reptin in the biogenesis of H\/ACA RNPs. RNA 18(10):1833\u20131845","journal-title":"RNA"},{"issue":"6","key":"3783_CR31","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1016\/j.molcel.2007.07.020","volume":"27","author":"G Cristofari","year":"2007","unstructured":"Cristofari G et al (2007) Human telomerase RNA accumulation in cajal bodies facilitates telomerase recruitment to telomeres and telomere elongation. Mol Cell 27(6):882\u2013889","journal-title":"Mol Cell"},{"issue":"5349","key":"3783_CR32","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1126\/science.279.5349.349","volume":"279","author":"AG Bodnar","year":"1998","unstructured":"Bodnar AG et al (1998) Extension of life-span by introduction of telomerase into normal human cells. Science 279(5349):349\u2013352","journal-title":"Science"},{"issue":"6","key":"3783_CR33","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1111\/j.1349-7006.2008.00815.x","volume":"99","author":"Y Cao","year":"2008","unstructured":"Cao Y, Bryan TM, Reddel RR (2008) Increased copy number of the TERT and TERC telomerase subunit genes in cancer cells. Cancer Sci 99(6):1092\u20131099","journal-title":"Cancer Sci"},{"issue":"8","key":"3783_CR34","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1007\/s00018-016-2146-9","volume":"73","author":"SC Akincilar","year":"2016","unstructured":"Akincilar SC, Unal B, Tergaonkar V (2016) Reactivation of telomerase in cancer. Cell Mol Life Sci 73(8):1659\u20131670","journal-title":"Cell Mol Life Sci"},{"issue":"5\u20136","key":"3783_CR35","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1038\/sj.bjc.6690433","volume":"80","author":"PH Rooney","year":"1999","unstructured":"Rooney PH et al (1999) Comparative genomic hybridization and chromosomal instability in solid tumours. Br J Cancer 80(5\u20136):862\u2013873","journal-title":"Br J Cancer"},{"issue":"5","key":"3783_CR36","first-page":"1107","volume":"152","author":"S Knuutila","year":"1998","unstructured":"Knuutila S et al (1998) DNA copy number amplifications in human neoplasms: review of comparative genomic hybridization studies. Am J Pathol 152(5):1107\u20131123","journal-title":"Am J Pathol"},{"issue":"4","key":"3783_CR37","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1002\/gcc.20198","volume":"43","author":"YP Mosse","year":"2005","unstructured":"Mosse YP et al (2005) High-resolution detection and mapping of genomic DNA alterations in neuroblastoma. Genes Chromosomes Cancer 43(4):390\u2013403","journal-title":"Genes Chromosomes Cancer"},{"issue":"3","key":"3783_CR38","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1002\/gcc.20137","volume":"42","author":"BP Coe","year":"2005","unstructured":"Coe BP et al (2005) High-resolution chromosome arm 5p array CGH analysis of small cell lung carcinoma cell lines. Genes Chromosomes Cancer 42(3):308\u2013313","journal-title":"Genes Chromosomes Cancer"},{"issue":"15","key":"3783_CR39","doi-asserted-by":"publisher","first-page":"6021","DOI":"10.1073\/pnas.1303607110","volume":"110","author":"PJ Killela","year":"2013","unstructured":"Killela PJ et al (2013) TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal. Proc Natl Acad Sci U S A 110(15):6021\u20136026","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"3783_CR40","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1038\/bjc.2013.312","volume":"109","author":"KG Griewank","year":"2013","unstructured":"Griewank KG et al (2013) TERT promoter mutations in ocular melanoma distinguish between conjunctival and uveal tumours. Br J Cancer 109(2):497\u2013501","journal-title":"Br J Cancer"},{"issue":"9","key":"3783_CR41","doi-asserted-by":"publisher","first-page":"E1562","DOI":"10.1210\/jc.2013-2383","volume":"98","author":"I Landa","year":"2013","unstructured":"Landa I et al (2013) Frequent somatic TERT promoter mutations in thyroid cancer: higher prevalence in advanced forms of the disease. J Clin Endocrinol Metab 98(9):E1562\u2013E1566","journal-title":"J Clin Endocrinol Metab"},{"key":"3783_CR42","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.1038\/ncomms3185","volume":"4","author":"J Vinagre","year":"2013","unstructured":"Vinagre J et al (2013) Frequency of TERT promoter mutations in human cancers. Nat Commun 4:2185","journal-title":"Nat Commun"},{"issue":"6225","key":"3783_CR43","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1126\/science.1260200","volume":"347","author":"S Borah","year":"2015","unstructured":"Borah S et al (2015) Cancer. TERT promoter mutations and telomerase reactivation in urothelial cancer. Science 347(6225):1006\u20131010","journal-title":"Science"},{"issue":"50","key":"3783_CR44","doi-asserted-by":"publisher","first-page":"14402","DOI":"10.1073\/pnas.1611106113","volume":"113","author":"Y Li","year":"2016","unstructured":"Li Y et al (2016) Activation of mutant TERT promoter by RAS-ERK signaling is a key step in malignant progression of BRAF-mutant human melanomas. Proc Natl Acad Sci U S A 113(50):14402\u201314407","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"3783_CR45","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1038\/ncb3240","volume":"17","author":"Y Li","year":"2015","unstructured":"Li Y et al (2015) Non-canonical NF-kappaB signalling and ETS1\/2 cooperatively drive C250T mutant TERT promoter activation. Nat Cell Biol 17(10):1327\u20131338","journal-title":"Nat Cell Biol"},{"issue":"1","key":"3783_CR46","doi-asserted-by":"publisher","first-page":"3183","DOI":"10.1038\/s41467-018-05644-0","volume":"9","author":"X Xu","year":"2018","unstructured":"Xu X et al (2018) Structural basis for reactivating the mutant TERT promoter by cooperative binding of p52 and ETS1. Nat Commun 9(1):3183","journal-title":"Nat Commun"},{"issue":"6238","key":"3783_CR47","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1126\/science.aab0015","volume":"348","author":"RJ Bell","year":"2015","unstructured":"Bell RJ et al (2015) Cancer. The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer. Science 348(6238):1036\u20131039","journal-title":"Science"},{"issue":"11","key":"3783_CR48","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1158\/2159-8290.CD-16-0177","volume":"6","author":"SC Akincilar","year":"2016","unstructured":"Akincilar SC et al (2016) Long-range chromatin interactions drive mutant TERT promoter activation. Cancer Discov 6(11):1276\u20131291","journal-title":"Cancer Discov"},{"issue":"8","key":"3783_CR49","first-page":"1743","volume":"63","author":"C Lindvall","year":"2003","unstructured":"Lindvall C et al (2003) Molecular characterization of human telomerase reverse transcriptase-immortalized human fibroblasts by gene expression profiling: activation of the epiregulin gene. Cancer Res 63(8):1743\u20131747","journal-title":"Cancer Res"},{"issue":"2","key":"3783_CR50","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1091\/mbc.e05-09-0903","volume":"17","author":"RL Tomlinson","year":"2006","unstructured":"Tomlinson RL et al (2006) Cell cycle-regulated trafficking of human telomerase to telomeres. Mol Biol Cell 17(2):955\u2013965","journal-title":"Mol Biol Cell"},{"issue":"1","key":"3783_CR51","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1101\/gad.2006411","volume":"25","author":"F Zhong","year":"2011","unstructured":"Zhong F et al (2011) Disruption of telomerase trafficking by TCAB1 mutation causes dyskeratosis congenita. Genes Dev 25(1):11\u201316","journal-title":"Genes Dev"},{"key":"3783_CR52","doi-asserted-by":"publisher","first-page":"133","DOI":"10.3389\/fonc.2012.00133","volume":"2","author":"I Chiodi","year":"2012","unstructured":"Chiodi I, Mondello C (2012) Telomere-independent functions of telomerase in nuclei, cytoplasm, and mitochondria. Front Oncol 2:133","journal-title":"Front Oncol"},{"issue":"1","key":"3783_CR53","doi-asserted-by":"publisher","first-page":"17","DOI":"10.3390\/antiox6010017","volume":"6","author":"MB Ozturk","year":"2017","unstructured":"Ozturk MB, Li Y, Tergaonkar V (2017) Current insights to regulation and role of telomerase in human diseases. Antioxidants (Basel) 6(1):17","journal-title":"Antioxidants (Basel)"},{"key":"3783_CR54","doi-asserted-by":"publisher","first-page":"22886","DOI":"10.1038\/srep22886","volume":"6","author":"H Liu","year":"2016","unstructured":"Liu H et al (2016) hTERT promotes cell adhesion and migration independent of telomerase activity. Sci Rep 6:22886","journal-title":"Sci Rep"},{"issue":"4","key":"3783_CR55","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/j.bbrc.2009.06.116","volume":"386","author":"L Zhou","year":"2009","unstructured":"Zhou L et al (2009) Telomerase reverse transcriptase activates the expression of vascular endothelial growth factor independent of telomerase activity. Biochem Biophys Res Commun 386(4):739\u2013743","journal-title":"Biochem Biophys Res Commun"},{"issue":"8","key":"3783_CR56","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1038\/sj.onc.1208232","volume":"24","author":"R Rahman","year":"2005","unstructured":"Rahman R, Latonen L, Wiman KG (2005) hTERT antagonizes p53-induced apoptosis independently of telomerase activity. Oncogene 24(8):1320\u20131327","journal-title":"Oncogene"},{"issue":"6","key":"3783_CR57","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1038\/s41419-020-2641-7","volume":"11","author":"WH Shin","year":"2020","unstructured":"Shin WH, Chung KC (2020) Human telomerase reverse transcriptase positively regulates mitophagy by inhibiting the processing and cytoplasmic release of mitochondrial PINK1. Cell Death Dis 11(6):425","journal-title":"Cell Death Dis"},{"issue":"Pt 7","key":"3783_CR58","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1242\/jcs.019372","volume":"121","author":"S Ahmed","year":"2008","unstructured":"Ahmed S et al (2008) Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress. J Cell Sci 121(Pt 7):1046\u20131053","journal-title":"J Cell Sci"},{"key":"3783_CR59","doi-asserted-by":"publisher","first-page":"104726","DOI":"10.1016\/j.phrs.2020.104726","volume":"155","author":"L Wu","year":"2020","unstructured":"Wu L et al (2020) Telomerase: Key regulator of inflammation and cancer. Pharmacol Res 155:104726","journal-title":"Pharmacol Res"},{"issue":"1","key":"3783_CR60","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1158\/0008-5472.CAN-10-1588","volume":"71","author":"IR Indran","year":"2011","unstructured":"Indran IR, Hande MP, Pervaiz S (2011) hTERT overexpression alleviates intracellular ROS production, improves mitochondrial function, and inhibits ROS-mediated apoptosis in cancer cells. Cancer Res 71(1):266\u2013276","journal-title":"Cancer Res"},{"issue":"6788","key":"3783_CR61","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1038\/35015674","volume":"405","author":"J Wang","year":"2000","unstructured":"Wang J, Hannon GJ, Beach DH (2000) Risky immortalization by telomerase. Nature 405(6788):755\u2013756","journal-title":"Nature"},{"issue":"23","key":"3783_CR62","doi-asserted-by":"publisher","first-page":"3784","DOI":"10.1038\/sj.onc.1205455","volume":"21","author":"H Xiang","year":"2002","unstructured":"Xiang H et al (2002) Human telomerase accelerates growth of lens epithelial cells through regulation of the genes mediating RB\/E2F pathway. Oncogene 21(23):3784\u20133791","journal-title":"Oncogene"},{"issue":"5","key":"3783_CR63","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1016\/S0002-9440(10)65025-0","volume":"156","author":"DG Farwell","year":"2000","unstructured":"Farwell DG et al (2000) Genetic and epigenetic changes in human epithelial cells immortalized by telomerase. Am J Pathol 156(5):1537\u20131547","journal-title":"Am J Pathol"},{"issue":"7251","key":"3783_CR64","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1038\/nature08137","volume":"460","author":"JI Park","year":"2009","unstructured":"Park JI et al (2009) Telomerase modulates Wnt signalling by association with target gene chromatin. Nature 460(7251):66\u201372","journal-title":"Nature"},{"issue":"5","key":"3783_CR65","doi-asserted-by":"publisher","first-page":"2109","DOI":"10.1172\/JCI79134","volume":"125","author":"CM Koh","year":"2015","unstructured":"Koh CM et al (2015) Telomerase regulates MYC-driven oncogenesis independent of its reverse transcriptase activity. J Clin Invest 125(5):2109\u20132122","journal-title":"J Clin Invest"},{"key":"3783_CR66","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fcell.2017.00001","volume":"5","author":"E Khattar","year":"2017","unstructured":"Khattar E, Tergaonkar V (2017) Transcriptional regulation of telomerase reverse transcriptase (TERT) by MYC. Front Cell Dev Biol 5:1","journal-title":"Front Cell Dev Biol"},{"key":"3783_CR67","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1186\/1471-2164-15-74","volume":"15","author":"A Herbst","year":"2014","unstructured":"Herbst A et al (2014) Comprehensive analysis of beta-catenin target genes in colorectal carcinoma cell lines with deregulated Wnt\/beta-catenin signaling. BMC Genom 15:74","journal-title":"BMC Genom"},{"issue":"9","key":"3783_CR68","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1016\/j.febslet.2015.02.035","volume":"589","author":"SC Akincilar","year":"2015","unstructured":"Akincilar SC et al (2015) Quantitative assessment of telomerase components in cancer cell lines. FEBS Lett 589(9):974\u2013984","journal-title":"FEBS Lett"},{"issue":"10","key":"3783_CR69","doi-asserted-by":"publisher","first-page":"4045","DOI":"10.1172\/JCI86042","volume":"126","author":"E Khattar","year":"2016","unstructured":"Khattar E et al (2016) Telomerase reverse transcriptase promotes cancer cell proliferation by augmenting tRNA expression. J Clin Invest 126(10):4045\u20134060","journal-title":"J Clin Invest"},{"issue":"2","key":"3783_CR70","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.tibs.2003.12.003","volume":"29","author":"Y Yamamoto","year":"2004","unstructured":"Yamamoto Y, Gaynor RB (2004) IkappaB kinases: key regulators of the NF-kappaB pathway. Trends Biochem Sci 29(2):72\u201379","journal-title":"Trends Biochem Sci"},{"key":"3783_CR71","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-322980","author":"SC Akincilar","year":"2020","unstructured":"Akincilar SC et al (2020) NAIL: an evolutionarily conserved lncRNA essential for licensing coordinated activation of p38 and NFkappaB in colitis. Gut. https:\/\/doi.org\/10.1136\/gutjnl-2020-322980","journal-title":"Gut"},{"issue":"1\u20132","key":"3783_CR72","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.cell.2016.12.012","volume":"168","author":"Q Zhang","year":"2017","unstructured":"Zhang Q, Lenardo MJ, Baltimore D (2017) 30 Years of NF-kappaB: a blossoming of relevance to human pathobiology. Cell 168(1\u20132):37\u201357","journal-title":"Cell"},{"issue":"12","key":"3783_CR73","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1038\/ncb2621","volume":"14","author":"A Ghosh","year":"2012","unstructured":"Ghosh A et al (2012) Telomerase directly regulates NF-kappaB-dependent transcription. Nat Cell Biol 14(12):1270\u20131281","journal-title":"Nat Cell Biol"},{"issue":"3","key":"3783_CR74","doi-asserted-by":"publisher","first-page":"82","DOI":"10.3390\/biomedicines6030082","volume":"6","author":"YR Puar","year":"2018","unstructured":"Puar YR et al (2018) Evidence for the involvement of the master transcription factor NF-kappaB in cancer initiation and progression. Biomedicines 6(3):82","journal-title":"Biomedicines"},{"key":"3783_CR75","doi-asserted-by":"publisher","first-page":"4599","DOI":"10.1038\/ncomms5599","volume":"5","author":"OG Gonzalez","year":"2014","unstructured":"Gonzalez OG et al (2014) Telomerase stimulates ribosomal DNA transcription under hyperproliferative conditions. Nat Commun 5:4599","journal-title":"Nat Commun"},{"issue":"1","key":"3783_CR76","first-page":"18","volume":"63","author":"M Akiyama","year":"2003","unstructured":"Akiyama M et al (2003) Nuclear factor-kappaB p65 mediates tumor necrosis factor alpha-induced nuclear translocation of telomerase reverse transcriptase protein. Cancer Res 63(1):18\u201321","journal-title":"Cancer Res"},{"issue":"1","key":"3783_CR77","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1007\/s10620-018-5318-7","volume":"64","author":"Y Hu","year":"2019","unstructured":"Hu Y et al (2019) The clinicopathological correlations of hTERC amplification with esophageal squamous cell precursor lesions. Dig Dis Sci 64(1):68\u201375","journal-title":"Dig Dis Sci"},{"issue":"9","key":"3783_CR78","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1038\/sj.onc.1201066","volume":"14","author":"AI Soder","year":"1997","unstructured":"Soder AI et al (1997) Amplification, increased dosage and in situ expression of the telomerase RNA gene in human cancer. Oncogene 14(9):1013\u20131021","journal-title":"Oncogene"},{"issue":"8","key":"3783_CR79","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1038\/sj.onc.1201620","volume":"16","author":"AI Soder","year":"1998","unstructured":"Soder AI et al (1998) Tumour specific regulation of telomerase RNA gene expression visualized by in situ hybridization. Oncogene 16(8):979\u2013983","journal-title":"Oncogene"},{"key":"3783_CR80","doi-asserted-by":"publisher","first-page":"104354","DOI":"10.1016\/j.yexmp.2019.104354","volume":"112","author":"CB Storti","year":"2020","unstructured":"Storti CB et al (2020) Telomere-associated genes and telomeric lncRNAs are biomarker candidates in lung squamous cell carcinoma (LUSC). Exp Mol Pathol 112:104354","journal-title":"Exp Mol Pathol"},{"issue":"3","key":"3783_CR81","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/ng.3781","volume":"49","author":"FP Barthel","year":"2017","unstructured":"Barthel FP et al (2017) Systematic analysis of telomere length and somatic alterations in 31 cancer types. Nat Genet 49(3):349\u2013357","journal-title":"Nat Genet"},{"issue":"10","key":"3783_CR82","doi-asserted-by":"publisher","first-page":"1778","DOI":"10.1038\/s41388-018-0544-1","volume":"38","author":"A Kheimar","year":"2019","unstructured":"Kheimar A et al (2019) Overexpression of cellular telomerase RNA enhances virus-induced cancer formation. Oncogene 38(10):1778\u20131786","journal-title":"Oncogene"},{"issue":"5","key":"3783_CR83","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1084\/jem.20052240","volume":"203","author":"S Trapp","year":"2006","unstructured":"Trapp S et al (2006) A virus-encoded telomerase RNA promotes malignant T cell lymphomagenesis. J Exp Med 203(5):1307\u20131317","journal-title":"J Exp Med"},{"issue":"5","key":"3783_CR84","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1038\/cgt.2010.81","volume":"18","author":"Y Li","year":"2011","unstructured":"Li Y et al (2011) Telomerase inhibition strategies by siRNAs against either hTR or hTERT in oral squamous cell carcinoma. Cancer Gene Ther 18(5):318\u2013325","journal-title":"Cancer Gene Ther"},{"issue":"5","key":"3783_CR85","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1007\/s11805-006-0097-x","volume":"3","author":"R Wen","year":"2006","unstructured":"Wen R et al (2006) Attenuation of telomerase activity by siRNA targeted telomerase RNA leads to apoptosis and inhibition of proliferation in human renal carcinoma cells. Chinese J Clin Oncol 3(5):326\u2013331","journal-title":"Chinese J Clin Oncol"},{"issue":"5228","key":"3783_CR86","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1126\/science.7544491","volume":"269","author":"J Feng","year":"1995","unstructured":"Feng J et al (1995) The RNA component of human telomerase. Science 269(5228):1236\u20131241","journal-title":"Science"},{"issue":"3","key":"3783_CR87","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1038\/sj.embor.7400359","volume":"6","author":"ML Cayuela","year":"2005","unstructured":"Cayuela ML, Flores JM, Blasco MA (2005) The telomerase RNA component Terc is required for the tumour-promoting effects of Tert overexpression. EMBO Rep 6(3):268\u2013274","journal-title":"EMBO Rep"},{"key":"3783_CR88","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.07918","author":"K Chiba","year":"2015","unstructured":"Chiba K et al (2015) Cancer-associated TERT promoter mutations abrogate telomerase silencing. Elife. https:\/\/doi.org\/10.7554\/eLife.07918","journal-title":"Elife"},{"issue":"1","key":"3783_CR89","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1038\/79089","volume":"26","author":"E Gonz\u00e1lez-Su\u00e1rez","year":"2000","unstructured":"Gonz\u00e1lez-Su\u00e1rez E et al (2000) Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis. Nat Genet 26(1):114\u2013117","journal-title":"Nat Genet"},{"issue":"5","key":"3783_CR90","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1038\/ng.2941","volume":"46","author":"J Shi","year":"2014","unstructured":"Shi J et al (2014) Rare missense variants in POT1 predispose to familial cutaneous malignant melanoma. Nat Genet 46(5):482\u2013486","journal-title":"Nat Genet"},{"issue":"3","key":"3783_CR91","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1182\/blood-2003-01-0335","volume":"102","author":"H Yamaguchi","year":"2003","unstructured":"Yamaguchi H et al (2003) Mutations of the human telomerase RNA gene (TERC) in aplastic anemia and myelodysplastic syndrome. Blood 102(3):916\u2013918","journal-title":"Blood"},{"issue":"9","key":"3783_CR92","doi-asserted-by":"publisher","first-page":"3377","DOI":"10.1172\/JCI87547","volume":"126","author":"B Boyraz","year":"2016","unstructured":"Boyraz B et al (2016) Posttranscriptional manipulation of TERC reverses molecular hallmarks of telomere disease. J Clin Invest 126(9):3377\u20133382","journal-title":"J Clin Invest"},{"issue":"5","key":"3783_CR93","doi-asserted-by":"publisher","first-page":"2151","DOI":"10.1172\/JCI78963","volume":"125","author":"H Tummala","year":"2015","unstructured":"Tummala H et al (2015) Poly(A)-specific ribonuclease deficiency impacts telomere biology and causes dyskeratosis congenita. J Clin Invest 125(5):2151\u20132160","journal-title":"J Clin Invest"},{"issue":"2","key":"3783_CR94","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1136\/gut.2011.239772","volume":"61","author":"AM Jones","year":"2012","unstructured":"Jones AM et al (2012) TERC polymorphisms are associated both with susceptibility to colorectal cancer and with longer telomeres. Gut 61(2):248\u2013254","journal-title":"Gut"},{"issue":"8","key":"3783_CR95","doi-asserted-by":"publisher","first-page":"3170","DOI":"10.1158\/0008-5472.CAN-09-4595","volume":"70","author":"KA Pooley","year":"2010","unstructured":"Pooley KA et al (2010) Telomere length in prospective and retrospective cancer case-control studies. Cancer Res 70(8):3170\u20133176","journal-title":"Cancer Res"},{"issue":"6 Pt 1","key":"3783_CR96","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1083\/jcb.127.6.1505","volume":"127","author":"UT Meier","year":"1994","unstructured":"Meier UT, Blobel G (1994) NAP57, a mammalian nucleolar protein with a putative homolog in yeast and bacteria. J Cell Biol 127(6 Pt 1):1505\u20131514","journal-title":"J Cell Biol"},{"issue":"11","key":"3783_CR97","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1016\/j.chembiol.2006.09.009","volume":"13","author":"T Hamma","year":"2006","unstructured":"Hamma T, Ferre-D\u2019Amare AR (2006) Pseudouridine synthases. Chem Biol 13(11):1125\u20131135","journal-title":"Chem Biol"},{"issue":"5","key":"3783_CR98","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1038\/s41416-019-0695-z","volume":"122","author":"P Hou","year":"2020","unstructured":"Hou P et al (2020) DKC1 enhances angiogenesis by promoting HIF-1alpha transcription and facilitates metastasis in colorectal cancer. Br J Cancer 122(5):668\u2013679","journal-title":"Br J Cancer"},{"issue":"4","key":"3783_CR99","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1016\/j.bbrc.2007.08.071","volume":"362","author":"F Alawi","year":"2007","unstructured":"Alawi F, Lee MN (2007) DKC1 is a direct and conserved transcriptional target of c-MYC. Biochem Biophys Res Commun 362(4):893\u2013898","journal-title":"Biochem Biophys Res Commun"},{"issue":"7","key":"3783_CR100","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1002\/hed.21579","volume":"33","author":"F Alawi","year":"2011","unstructured":"Alawi F et al (2011) Correlation of dyskerin expression with active proliferation independent of telomerase. Head Neck 33(7):1041\u20131051","journal-title":"Head Neck"},{"issue":"16","key":"3783_CR101","doi-asserted-by":"publisher","first-page":"4695","DOI":"10.1158\/1078-0432.CCR-06-2818","volume":"13","author":"F Westermann","year":"2007","unstructured":"Westermann F et al (2007) High Skp2 expression characterizes high-risk neuroblastomas independent of MYCN status. Clin Cancer Res 13(16):4695\u20134703","journal-title":"Clin Cancer Res"},{"issue":"12","key":"3783_CR102","doi-asserted-by":"publisher","first-page":"3171","DOI":"10.1172\/JCI29401","volume":"116","author":"R Piva","year":"2006","unstructured":"Piva R et al (2006) Functional validation of the anaplastic lymphoma kinase signature identifies CEBPB and BCL2A1 as critical target genes. J Clin Invest 116(12):3171\u20133182","journal-title":"J Clin Invest"},{"issue":"1","key":"3783_CR103","doi-asserted-by":"publisher","first-page":"110","DOI":"10.4161\/cbt.3.1.662","volume":"3","author":"SL McDonald","year":"2004","unstructured":"McDonald SL et al (2004) Expression analysis of genes identified by molecular profiling of VGP melanomas and MGP melanoma-positive lymph nodes. Cancer Biol Ther 3(1):110\u2013120","journal-title":"Cancer Biol Ther"},{"issue":"1","key":"3783_CR104","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1002\/path.2023","volume":"210","author":"L Montanaro","year":"2006","unstructured":"Montanaro L et al (2006) Dyskerin expression influences the level of ribosomal RNA pseudo-uridylation and telomerase RNA component in human breast cancer. J Pathol 210(1):10\u201318","journal-title":"J Pathol"},{"issue":"6","key":"3783_CR105","first-page":"483","volume":"30","author":"L Montanaro","year":"2008","unstructured":"Montanaro L et al (2008) Relationship between dyskerin expression and telomerase activity in human breast cancer. Cell Oncol 30(6):483\u2013490","journal-title":"Cell Oncol"},{"issue":"8","key":"3783_CR106","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1038\/sj.bjc.6605299","volume":"101","author":"P Sieron","year":"2009","unstructured":"Sieron P et al (2009) DKC1 overexpression associated with prostate cancer progression. Br J Cancer 101(8):1410\u20131416","journal-title":"Br J Cancer"},{"issue":"3","key":"3783_CR107","doi-asserted-by":"publisher","first-page":"321","DOI":"10.3892\/ijmm_00000348","volume":"25","author":"A Witkowska","year":"2010","unstructured":"Witkowska A et al (2010) Expression profile of significant immortalization genes in colon cancer. Int J Mol Med 25(3):321\u2013329","journal-title":"Int J Mol Med"},{"issue":"11","key":"3783_CR108","doi-asserted-by":"publisher","first-page":"4376","DOI":"10.1091\/mbc.e03-05-0279","volume":"14","author":"ME Schaner","year":"2003","unstructured":"Schaner ME et al (2003) Gene expression patterns in ovarian carcinomas. Mol Biol Cell 14(11):4376\u20134386","journal-title":"Mol Biol Cell"},{"issue":"8","key":"3783_CR109","doi-asserted-by":"publisher","first-page":"e43147","DOI":"10.1371\/journal.pone.0043147","volume":"7","author":"B Liu","year":"2012","unstructured":"Liu B et al (2012) Dyskerin overexpression in human hepatocellular carcinoma is associated with advanced clinical stage and poor patient prognosis. PLoS ONE 7(8):e43147","journal-title":"PLoS ONE"},{"issue":"6","key":"3783_CR110","doi-asserted-by":"publisher","first-page":"e2249","DOI":"10.1038\/cddis.2016.148","volume":"7","author":"T Sbarrato","year":"2016","unstructured":"Sbarrato T et al (2016) A ribosome-related signature in peripheral blood CLL B cells is linked to reduced survival following treatment. Cell Death Dis 7(6):e2249","journal-title":"Cell Death Dis"},{"issue":"12","key":"3783_CR111","doi-asserted-by":"publisher","first-page":"3604","DOI":"10.1158\/0008-5472.CAN-15-0879","volume":"76","author":"R O'Brien","year":"2016","unstructured":"O\u2019Brien R et al (2016) MYC-Driven Neuroblastomas Are Addicted to a Telomerase-Independent Function of Dyskerin. Cancer Res 76(12):3604\u20133617","journal-title":"Cancer Res"},{"issue":"5","key":"3783_CR112","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/S1470-2045(02)00729-5","volume":"3","author":"JA McCaul","year":"2002","unstructured":"McCaul JA et al (2002) Telomerase inhibition and the future management of head-and-neck cancer. Lancet Oncol 3(5):280\u2013288","journal-title":"Lancet Oncol"},{"issue":"13","key":"3783_CR113","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1093\/hmg\/ddm111","volume":"16","author":"AJ Walne","year":"2007","unstructured":"Walne AJ et al (2007) Genetic heterogeneity in autosomal recessive dyskeratosis congenita with one subtype due to mutations in the telomerase-associated protein NOP10. Hum Mol Genet 16(13):1619\u20131629","journal-title":"Hum Mol Genet"},{"issue":"6","key":"3783_CR114","doi-asserted-by":"publisher","first-page":"1902465","DOI":"10.1183\/13993003.02465-2019","volume":"55","author":"C Kannengiesser","year":"2020","unstructured":"Kannengiesser C et al (2020) First heterozygous <em>NOP10<\/em> mutation in familial pulmonary fibrosis. Eur Respir J 55(6):1902465","journal-title":"Eur Respir J"},{"issue":"6","key":"3783_CR115","doi-asserted-by":"publisher","first-page":"e0179883","DOI":"10.1371\/journal.pone.0179883","volume":"12","author":"PC Dos Santos","year":"2017","unstructured":"Dos Santos PC et al (2017) Dysregulation of H\/ACA ribonucleoprotein components in chronic lymphocytic leukemia. PLoS ONE 12(6):e0179883","journal-title":"PLoS ONE"},{"issue":"6","key":"3783_CR116","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1097\/PAT.0b013e3283583bf6","volume":"44","author":"MS Kim","year":"2012","unstructured":"Kim MS et al (2012) Expressional analysis of NOLA1, NOLA2, NOLA3 and DKC1, the core proteins in H\/ACA riboproteins, in gastric and colorectal cancers. Pathology 44(6):576\u2013577","journal-title":"Pathology"},{"issue":"3","key":"3783_CR117","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1002\/pbc.21813","volume":"52","author":"S Pigullo","year":"2009","unstructured":"Pigullo S et al (2009) NOLA1 gene mutations in acquired aplastic anemia. Pediatr Blood Cancer 52(3):376\u2013378","journal-title":"Pediatr Blood Cancer"},{"issue":"23","key":"3783_CR118","doi-asserted-by":"publisher","first-page":"8073","DOI":"10.1073\/pnas.0800042105","volume":"105","author":"T Vulliamy","year":"2008","unstructured":"Vulliamy T et al (2008) Mutations in the telomerase component NHP2 cause the premature ageing syndrome dyskeratosis congenita. Proc Natl Acad Sci 105(23):8073\u20138078","journal-title":"Proc Natl Acad Sci"},{"key":"3783_CR119","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1186\/1476-4598-13-180","volume":"13","author":"CK Sun","year":"2014","unstructured":"Sun CK et al (2014) TCAB1: a potential target for diagnosis and therapy of head and neck carcinomas. Mol Cancer 13:180","journal-title":"Mol Cancer"},{"issue":"1","key":"3783_CR120","doi-asserted-by":"publisher","first-page":"e114","DOI":"10.1038\/cddis.2010.90","volume":"2","author":"S Mahmoudi","year":"2011","unstructured":"Mahmoudi S et al (2011) WRAP53 promotes cancer cell survival and is a potential target for cancer therapy. Cell Death Dis 2(1):e114\u2013e114","journal-title":"Cell Death Dis"},{"issue":"3","key":"3783_CR121","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.3892\/ol.2014.2306","volume":"8","author":"P Yuan","year":"2014","unstructured":"Yuan P et al (2014) Telomerase Cajal body protein 1 depletion inhibits telomerase trafficking to telomeres and induces G(1) cell cycle arrest in A549 cells. Oncol Lett 8(3):1009\u20131016","journal-title":"Oncol Lett"},{"issue":"1","key":"3783_CR122","doi-asserted-by":"publisher","first-page":"3218","DOI":"10.1038\/s41598-017-03156-3","volume":"7","author":"K Wang","year":"2017","unstructured":"Wang K et al (2017) Epstein-Barr virus-induced up-regulation of TCAB1 is involved in the DNA damage response in nasopharyngeal carcinoma. Sci Rep 7(1):3218","journal-title":"Sci Rep"},{"issue":"10","key":"3783_CR123","doi-asserted-by":"publisher","first-page":"e1892","DOI":"10.1038\/cddis.2015.250","volume":"6","author":"E Hedstr\u00f6m","year":"2015","unstructured":"Hedstr\u00f6m E et al (2015) Downregulation of the cancer susceptibility protein WRAP53\u03b2 in epithelial ovarian cancer leads to defective DNA repair and poor clinical outcome. Cell Death Dis 6(10):e1892\u2013e1892","journal-title":"Cell Death Dis"},{"issue":"1","key":"3783_CR124","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.oraloncology.2014.10.003","volume":"51","author":"S Garvin","year":"2015","unstructured":"Garvin S et al (2015) Nuclear expression of WRAP53\u03b2 is associated with a positive response to radiotherapy and improved overall survival in patients with head and neck squamous cell carcinoma. Oral Oncol 51(1):24\u201330","journal-title":"Oral Oncol"},{"issue":"4","key":"3783_CR125","doi-asserted-by":"publisher","first-page":"2062","DOI":"10.3892\/or.2017.5898","volume":"38","author":"K Tiefenb\u00f6ck-Hansson","year":"2017","unstructured":"Tiefenb\u00f6ck-Hansson K et al (2017) WRAP53\u03b2, survivin and p16INK4a expression as potential predictors of radiotherapy\/chemoradiotherapy response in T2N0-T3N0 glottic laryngeal cancer. Oncol Rep 38(4):2062\u20132068","journal-title":"Oncol Rep"},{"issue":"6","key":"3783_CR126","doi-asserted-by":"publisher","first-page":"e2267","DOI":"10.1038\/cddis.2016.172","volume":"7","author":"H Rassoolzadeh","year":"2016","unstructured":"Rassoolzadeh H et al (2016) Overexpression of the scaffold WD40 protein WRAP53\u03b2 enhances the repair of and cell survival from DNA double-strand breaks. Cell Death Dis 7(6):e2267","journal-title":"Cell Death Dis"},{"issue":"17","key":"3783_CR127","doi-asserted-by":"publisher","first-page":"6873","DOI":"10.1158\/0008-5472.CAN-08-0547","volume":"68","author":"O Huber","year":"2008","unstructured":"Huber O et al (2008) Pontin and reptin, two related ATPases with multiple roles in cancer. Cancer Res 68(17):6873\u20136876","journal-title":"Cancer Res"},{"issue":"5","key":"3783_CR128","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1007\/s00412-008-0170-8","volume":"117","author":"Z Cvackova","year":"2008","unstructured":"Cvackova Z et al (2008) Pontin is localized in nucleolar fibrillar centers. Chromosoma 117(5):487\u2013497","journal-title":"Chromosoma"},{"issue":"36","key":"3783_CR129","doi-asserted-by":"publisher","first-page":"4243","DOI":"10.1038\/onc.2012.442","volume":"32","author":"M Dalvai","year":"2013","unstructured":"Dalvai M et al (2013) H2A.Z-dependent crosstalk between enhancer and promoter regulates cyclin D1 expression. Oncogene 32(36):4243\u20134251","journal-title":"Oncogene"},{"issue":"7035","key":"3783_CR130","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1038\/nature03452","volume":"434","author":"JH Kim","year":"2005","unstructured":"Kim JH et al (2005) Transcriptional regulation of a metastasis suppressor gene by Tip60 and beta-catenin complexes. Nature 434(7035):921\u2013926","journal-title":"Nature"},{"issue":"4","key":"3783_CR131","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/j.mod.2004.11.010","volume":"122","author":"C Etard","year":"2005","unstructured":"Etard C et al (2005) Pontin and Reptin regulate cell proliferation in early Xenopus embryos in collaboration with c-Myc and Miz-1. Mech Dev 122(4):545\u2013556","journal-title":"Mech Dev"},{"issue":"3","key":"3783_CR132","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.devcel.2014.09.001","volume":"31","author":"A Magalska","year":"2014","unstructured":"Magalska A et al (2014) RuvB-like ATPases function in chromatin decondensation at the end of mitosis. Dev Cell 31(3):305\u2013318","journal-title":"Dev Cell"},{"issue":"1","key":"3783_CR133","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1038\/ncb2641","volume":"15","author":"PA Muller","year":"2013","unstructured":"Muller PA, Vousden KH (2013) p53 mutations in cancer. Nat Cell Biol 15(1):2\u20138","journal-title":"Nat Cell Biol"},{"issue":"11","key":"3783_CR134","doi-asserted-by":"publisher","first-page":"1824","DOI":"10.1038\/cdd.2015.33","volume":"22","author":"Y Zhao","year":"2015","unstructured":"Zhao Y et al (2015) Pontin, a new mutant p53-binding protein, promotes gain-of-function of mutant p53. Cell Death Differ 22(11):1824\u20131836","journal-title":"Cell Death Differ"},{"issue":"3","key":"3783_CR135","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1016\/j.jmb.2010.09.035","volume":"404","author":"MM Maslon","year":"2010","unstructured":"Maslon MM et al (2010) A divergent substrate-binding loop within the pro-oncogenic protein anterior gradient-2 forms a docking site for Reptin. J Mol Biol 404(3):418\u2013438","journal-title":"J Mol Biol"},{"issue":"9","key":"3783_CR136","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1002\/pro.2299","volume":"22","author":"TA Gray","year":"2013","unstructured":"Gray TA et al (2013) Development of a fluorescent monoclonal antibody-based assay to measure the allosteric effects of synthetic peptides on self-oligomerization of AGR2 protein. Protein Sci 22(9):1266\u20131278","journal-title":"Protein Sci"},{"issue":"5","key":"3783_CR137","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/j.bbapap.2016.02.011","volume":"1864","author":"DJ Clarke","year":"2016","unstructured":"Clarke DJ et al (2016) Mass spectrometry analysis of the oxidation states of the pro-oncogenic protein anterior gradient-2 reveals covalent dimerization via an intermolecular disulphide bond. Biochim Biophys Acta 1864(5):551\u2013561","journal-title":"Biochim Biophys Acta"},{"key":"3783_CR138","doi-asserted-by":"publisher","first-page":"58","DOI":"10.3389\/fmolb.2017.00058","volume":"4","author":"YQ Mao","year":"2017","unstructured":"Mao YQ, Houry WA (2017) The role of pontin and reptin in cellular physiology and cancer etiology. Front Mol Biosci 4:58","journal-title":"Front Mol Biosci"},{"issue":"4","key":"3783_CR139","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.febslet.2012.01.026","volume":"586","author":"C Xie","year":"2012","unstructured":"Xie C et al (2012) RUVBL2 is a novel repressor of ARF transcription. FEBS Lett 586(4):435\u2013441","journal-title":"FEBS Lett"},{"issue":"1","key":"3783_CR140","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.celrep.2016.05.082","volume":"16","author":"JI Perez-Perri","year":"2016","unstructured":"Perez-Perri JI et al (2016) The TIP60 complex is a conserved coactivator of HIF1A. Cell Rep 16(1):37\u201347","journal-title":"Cell Rep"},{"issue":"6","key":"3783_CR141","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1038\/nrc3064","volume":"11","author":"WR Wilson","year":"2011","unstructured":"Wilson WR, Hay MP (2011) Targeting hypoxia in cancer therapy. Nat Rev Cancer 11(6):393\u2013410","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"3783_CR142","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.molcel.2010.06.008","volume":"39","author":"JS Lee","year":"2010","unstructured":"Lee JS et al (2010) Negative regulation of hypoxic responses via induced Reptin methylation. Mol Cell 39(1):71\u201385","journal-title":"Mol Cell"},{"issue":"33","key":"3783_CR143","doi-asserted-by":"publisher","first-page":"13510","DOI":"10.1073\/pnas.1106106108","volume":"108","author":"JS Lee","year":"2011","unstructured":"Lee JS et al (2011) Hypoxia-induced methylation of a pontin chromatin remodeling factor. Proc Natl Acad Sci U S A 108(33):13510\u201313515","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3783_CR144","doi-asserted-by":"publisher","first-page":"17","DOI":"10.3389\/fmolb.2015.00017","volume":"2","author":"PM Matias","year":"2015","unstructured":"Matias PM et al (2015) The AAA+ proteins Pontin and Reptin enter adult age: from understanding their basic biology to the identification of selective inhibitors. Front Mol Biosci 2:17","journal-title":"Front Mol Biosci"},{"issue":"2","key":"3783_CR145","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/S1097-2765(01)00321-5","volume":"8","author":"L Fairall","year":"2001","unstructured":"Fairall L et al (2001) Structure of the TRFH dimerization domain of the human telomeric proteins TRF1 and TRF2. Mol Cell 8(2):351\u2013361","journal-title":"Mol Cell"},{"issue":"5519","key":"3783_CR146","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1126\/science.1060036","volume":"292","author":"P Baumann","year":"2001","unstructured":"Baumann P, Cech TR (2001) Pot1, the putative telomere end-binding protein in fission yeast and humans. Science 292(5519):1171\u20131175","journal-title":"Science"},{"issue":"32","key":"3783_CR147","doi-asserted-by":"publisher","first-page":"11874","DOI":"10.1073\/pnas.0605303103","volume":"103","author":"MS O'Connor","year":"2006","unstructured":"O\u2019Connor MS et al (2006) A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly. Proc Natl Acad Sci 103(32):11874\u201311879","journal-title":"Proc Natl Acad Sci"},{"issue":"4","key":"3783_CR148","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/70508","volume":"23","author":"SH Kim","year":"1999","unstructured":"Kim SH, Kaminker P, Campisi J (1999) TIN2, a new regulator of telomere length in human cells. Nat Genet 23(4):405\u2013412","journal-title":"Nat Genet"},{"issue":"18","key":"3783_CR149","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1016\/j.cub.2004.08.052","volume":"14","author":"BR Houghtaling","year":"2004","unstructured":"Houghtaling BR et al (2004) A dynamic molecular link between the telomere length regulator TRF1 and the chromosome end protector TRF2. Curr Biol 14(18):1621\u20131631","journal-title":"Curr Biol"},{"issue":"45","key":"3783_CR150","doi-asserted-by":"publisher","first-page":"47264","DOI":"10.1074\/jbc.M409047200","volume":"279","author":"JZ Ye","year":"2004","unstructured":"Ye JZ et al (2004) TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres. J Biol Chem 279(45):47264\u201347271","journal-title":"J Biol Chem"},{"issue":"7","key":"3783_CR151","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1038\/ncb1142","volume":"6","author":"D Liu","year":"2004","unstructured":"Liu D et al (2004) PTOP interacts with POT1 and regulates its localization to telomeres. Nat Cell Biol 6(7):673\u2013680","journal-title":"Nat Cell Biol"},{"issue":"14","key":"3783_CR152","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.1101\/gad.1215404","volume":"18","author":"JZ-S Ye","year":"2004","unstructured":"Ye JZ-S et al (2004) POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2\/TRF1 complex. Genes Dev 18(14):1649\u20131654","journal-title":"Genes Dev"},{"issue":"5","key":"3783_CR153","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/S0092-8674(00)80858-2","volume":"101","author":"B Li","year":"2000","unstructured":"Li B, Oestreich S, de Lange T (2000) Identification of human Rap1: implications for telomere evolution. Cell 101(5):471\u2013483","journal-title":"Cell"},{"issue":"6618","key":"3783_CR154","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1038\/385740a0","volume":"385","author":"B van Steensel","year":"1997","unstructured":"van Steensel B, de Lange T (1997) Control of telomere length by the human telomeric protein TRF1. Nature 385(6618):740\u2013743","journal-title":"Nature"},{"issue":"2","key":"3783_CR155","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1038\/ng1097-231","volume":"17","author":"D Broccoli","year":"1997","unstructured":"Broccoli D et al (1997) Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. Nat Genet 17(2):231\u2013235","journal-title":"Nat Genet"},{"issue":"1","key":"3783_CR156","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.cell.2009.06.021","volume":"138","author":"A Sfeir","year":"2009","unstructured":"Sfeir A et al (2009) Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication. Cell 138(1):90\u2013103","journal-title":"Cell"},{"issue":"17","key":"3783_CR157","doi-asserted-by":"publisher","first-page":"2060","DOI":"10.1101\/gad.543509","volume":"23","author":"P Mart\u00ednez","year":"2009","unstructured":"Mart\u00ednez P et al (2009) Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice. Genes Dev 23(17):2060\u20132075","journal-title":"Genes Dev"},{"issue":"12","key":"3783_CR158","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1002\/gcc.20608","volume":"47","author":"A Poonepalli","year":"2008","unstructured":"Poonepalli A et al (2008) Telomere-mediated genomic instability and the clinico-pathological parameters in breast cancer. Genes Chromosomes Cancer 47(12):1098\u20131109","journal-title":"Genes Chromosomes Cancer"},{"issue":"12","key":"3783_CR159","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1038\/sj.onc.1204229","volume":"20","author":"S Kishi","year":"2001","unstructured":"Kishi S et al (2001) Telomeric protein Pin2\/TRF1 induces mitotic entry and apoptosis in cells with short telomeres and is down-regulated in human breast tumors. Oncogene 20(12):1497\u20131508","journal-title":"Oncogene"},{"issue":"15","key":"3783_CR160","doi-asserted-by":"publisher","first-page":"25442","DOI":"10.18632\/oncotarget.16036","volume":"8","author":"J Heng","year":"2017","unstructured":"Heng J et al (2017) Integrated analysis of promoter methylation and expression of telomere related genes in breast cancer. Oncotarget 8(15):25442\u201325454","journal-title":"Oncotarget"},{"issue":"15","key":"3783_CR161","doi-asserted-by":"publisher","first-page":"4145","DOI":"10.1158\/0008-5472.CAN-13-2038","volume":"74","author":"R Dinami","year":"2014","unstructured":"Dinami R et al (2014) miR-155 Drives Telomere Fragility in Human Breast Cancer by Targeting TRF1. Can Res 74(15):4145\u20134156","journal-title":"Can Res"},{"issue":"1","key":"3783_CR162","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/S0002-9440(10)62233-X","volume":"166","author":"B-K Oh","year":"2005","unstructured":"Oh B-K et al (2005) Up-regulation of telomere-binding proteins, TRF1, TRF2, and TIN2 is related to telomere shortening during human multistep hepatocarcinogenesis. Am J Pathol 166(1):73\u201380","journal-title":"Am J Pathol"},{"issue":"9","key":"3783_CR163","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1007\/s00432-010-0795-x","volume":"136","author":"H Hu","year":"2010","unstructured":"Hu H et al (2010) Expression of TRF1, TRF2, TIN2, TERT, KU70, and BRCA1 proteins is associated with telomere shortening and may contribute to multistage carcinogenesis of gastric cancer. J Cancer Res Clin Oncol 136(9):1407\u20131414","journal-title":"J Cancer Res Clin Oncol"},{"issue":"11","key":"3783_CR164","doi-asserted-by":"publisher","first-page":"2979","DOI":"10.1158\/1078-0432.CCR-10-0142","volume":"16","author":"S Lantuejoul","year":"2010","unstructured":"Lantuejoul S et al (2010) Telomere maintenance and DNA damage responses during lung carcinogenesis. Clin Cancer Res 16(11):2979\u20132988","journal-title":"Clin Cancer Res"},{"issue":"5","key":"3783_CR165","doi-asserted-by":"publisher","first-page":"e64296","DOI":"10.1371\/journal.pone.0064296","volume":"8","author":"D La Torre","year":"2013","unstructured":"La Torre D et al (2013) Telomere length modulation in human astroglial brain tumors. PLoS ONE 8(5):e64296","journal-title":"PLoS ONE"},{"issue":"2","key":"3783_CR166","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.stemcr.2017.01.001","volume":"8","author":"RM Mari\u00f3n","year":"2017","unstructured":"Mari\u00f3n RM et al (2017) Common telomere changes during in vivo reprogramming and early stages of tumorigenesis. Stem Cell Rep 8(2):460\u2013475","journal-title":"Stem Cell Rep"},{"issue":"1","key":"3783_CR167","doi-asserted-by":"publisher","first-page":"1946","DOI":"10.1038\/ncomms2946","volume":"4","author":"RP Schneider","year":"2013","unstructured":"Schneider RP et al (2013) TRF1 is a stem cell marker and is essential for the generation of induced pluripotent stem cells. Nature Commun 4(1):1946","journal-title":"Nature Commun"},{"issue":"8","key":"3783_CR168","doi-asserted-by":"publisher","first-page":"3690","DOI":"10.1210\/jc.2002-020965","volume":"88","author":"H Kanauchi","year":"2003","unstructured":"Kanauchi H et al (2003) Diagnostic and prognostic value of fas and telomeric-repeat binding factor-1 genes in adrenal tumors. J Clin Endocrinol Metabol 88(8):3690\u20133693","journal-title":"J Clin Endocrinol Metabol"},{"issue":"3","key":"3783_CR169","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1002\/cncr.21625","volume":"106","author":"C Garcia-Aranda","year":"2006","unstructured":"Garcia-Aranda C et al (2006) Correlations of telomere length, telomerase activity, and telomeric-repeat binding factor 1 expression in colorectal carcinoma. Cancer 106(3):541\u2013551","journal-title":"Cancer"},{"issue":"2","key":"3783_CR170","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1111\/j.1349-7006.2010.01786.x","volume":"102","author":"K Kojima","year":"2011","unstructured":"Kojima K et al (2011) Telomerase activation without shortening of telomeric 3\u2019-overhang is a poor prognostic factor in human colorectal cancer. Cancer Sci 102(2):330\u2013335","journal-title":"Cancer Sci"},{"issue":"11","key":"3783_CR171","doi-asserted-by":"publisher","first-page":"1875","DOI":"10.1093\/annonc\/mdn405","volume":"19","author":"CM Raynaud","year":"2008","unstructured":"Raynaud CM et al (2008) Telomere shortening is correlated with the DNA damage response and telomeric protein down-regulation in colorectal preneoplastic lesions. Ann Oncol 19(11):1875\u20131881","journal-title":"Ann Oncol"},{"issue":"2","key":"3783_CR172","first-page":"269","volume":"21","author":"K Miyachi","year":"2002","unstructured":"Miyachi K et al (2002) Correlation between telomerase activity and telomeric-repeat binding factors in gastric cancer. J Exp Clin Cancer Res 21(2):269\u2013275","journal-title":"J Exp Clin Cancer Res"},{"issue":"3","key":"3783_CR173","first-page":"507","volume":"19","author":"N Matsutani","year":"2001","unstructured":"Matsutani N et al (2001) Expression of telomeric repeat binding factor 1 and 2 and TRF1-interacting nuclear protein 2 in human gastric carcinomas. Int J Oncol 19(3):507\u2013512","journal-title":"Int J Oncol"},{"issue":"5","key":"3783_CR174","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1016\/j.ccell.2017.10.006","volume":"32","author":"L Bejarano","year":"2017","unstructured":"Bejarano L et al (2017) Inhibition of TRF1 telomere protein impairs tumor initiation and progression in glioblastoma mouse models and patient-derived xenografts. Cancer Cell 32(5):590-607.e4","journal-title":"Cancer Cell"},{"issue":"2","key":"3783_CR175","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1002\/ijc.23376","volume":"123","author":"JE Lee","year":"2008","unstructured":"Lee JE et al (2008) Telomeric 3\u2019 overhangs in chronic HBV-related hepatitis and hepatocellular carcinoma. Int J Cancer 123(2):264\u2013272","journal-title":"Int J Cancer"},{"issue":"14","key":"3783_CR176","first-page":"5264","volume":"9","author":"M Igarashi","year":"2003","unstructured":"Igarashi M et al (2003) Interferon can block telomere erosion and in rare cases result in hepatocellular carcinoma development with telomeric repeat binding factor 1 overexpression in chronic hepatitis C. Clin Cancer Res 9(14):5264\u20135270","journal-title":"Clin Cancer Res"},{"issue":"1","key":"3783_CR177","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1002\/cncr.11428","volume":"98","author":"T Yokota","year":"2003","unstructured":"Yokota T et al (2003) Telomere length variation and maintenance in hepatocarcinogenesis. Cancer 98(1):110\u2013118","journal-title":"Cancer"},{"issue":"3","key":"3783_CR178","first-page":"593","volume":"18","author":"JH Ohyashiki","year":"2001","unstructured":"Ohyashiki JH et al (2001) Impaired telomere regulation mechanism by TRF1 (telomere-binding protein), but not TRF2 expression, in acute leukemia cells. Int J Oncol 18(3):593\u2013598","journal-title":"Int J Oncol"},{"issue":"9","key":"3783_CR179","doi-asserted-by":"publisher","first-page":"2090","DOI":"10.1002\/ijc.22026","volume":"119","author":"M Bellon","year":"2006","unstructured":"Bellon M et al (2006) Increased expression of telomere length regulating factors TRF1, TRF2 and TIN2 in patients with adult T-cell leukemia. Int J Cancer 119(9):2090\u20132097","journal-title":"Int J Cancer"},{"issue":"4","key":"3783_CR180","doi-asserted-by":"publisher","first-page":"2388","DOI":"10.1182\/blood-2007-09-111245","volume":"111","author":"D Poncet","year":"2008","unstructured":"Poncet D et al (2008) Changes in the expression of telomere maintenance genes suggest global telomere dysfunction in B-chronic lymphocytic leukemia. Blood 111(4):2388\u20132391","journal-title":"Blood"},{"issue":"2","key":"3783_CR181","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1038\/leu.2012.194","volume":"27","author":"L V\u00e9ron\u00e8se","year":"2013","unstructured":"V\u00e9ron\u00e8se L et al (2013) Telomeres and chromosomal instability in chronic lymphocytic leukemia. Leukemia 27(2):490\u2013493","journal-title":"Leukemia"},{"issue":"35","key":"3783_CR182","doi-asserted-by":"publisher","first-page":"56976","DOI":"10.18632\/oncotarget.10927","volume":"7","author":"R Gui\u00e8ze","year":"2016","unstructured":"Gui\u00e8ze R et al (2016) Telomere status in chronic lymphocytic leukemia with TP53 disruption. Oncotarget 7(35):56976\u201356985","journal-title":"Oncotarget"},{"issue":"4","key":"3783_CR183","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/sj.leu.2404141","volume":"20","author":"LJ Campbell","year":"2006","unstructured":"Campbell LJ et al (2006) hTERT, the catalytic component of telomerase, is downregulated in the haematopoietic stem cells of patients with chronic myeloid leukaemia. Leukemia 20(4):671\u2013679","journal-title":"Leukemia"},{"issue":"3","key":"3783_CR184","first-page":"1105","volume":"9","author":"K Nakanishi","year":"2003","unstructured":"Nakanishi K et al (2003) Expression of mRNAs for telomeric repeat binding factor (TRF)-1 and TRF2 in atypical adenomatous hyperplasia and adenocarcinoma of the lung. Clin Cancer Res 9(3):1105\u20131111","journal-title":"Clin Cancer Res"},{"issue":"1","key":"3783_CR185","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1002\/jso.20421","volume":"93","author":"J Hu","year":"2006","unstructured":"Hu J et al (2006) Expression of telomeric repeat binding factor 1 in non-small cell lung cancer. J Surg Oncol 93(1):62\u201367","journal-title":"J Surg Oncol"},{"issue":"19","key":"3783_CR186","doi-asserted-by":"publisher","first-page":"5720","DOI":"10.1158\/1078-0432.CCR-05-2809","volume":"12","author":"X Lin","year":"2006","unstructured":"Lin X et al (2006) Expression of telomere-associated genes as prognostic markers for overall survival in patients with non-small cell lung cancer. Clin Cancer Res 12(19):5720\u20135725","journal-title":"Clin Cancer Res"},{"issue":"5","key":"3783_CR187","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1054\/bjoc.2001.1954","volume":"85","author":"T Yajima","year":"2001","unstructured":"Yajima T et al (2001) Telomerase reverse transcriptase and telomeric-repeat binding factor protein 1 as regulators of telomerase activity in pancreatic cancer cells. Br J Cancer 85(5):752\u2013757","journal-title":"Br J Cancer"},{"key":"3783_CR188","doi-asserted-by":"publisher","first-page":"14929","DOI":"10.1038\/ncomms14929","volume":"8","author":"C Chen","year":"2017","unstructured":"Chen C et al (2017) Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer. Nature Commun 8:14929\u201314929","journal-title":"Nature Commun"},{"issue":"3","key":"3783_CR189","doi-asserted-by":"publisher","first-page":"e0115651","DOI":"10.1371\/journal.pone.0115651","volume":"10","author":"D Pal","year":"2015","unstructured":"Pal D et al (2015) Over-expression of telomere binding factors (TRF1 & TRF2) in renal cell carcinoma and their inhibition by using SiRNA induce apoptosis, reduce cell proliferation and migration invitro. PLoS ONE 10(3):e0115651\u2013e0115651","journal-title":"PLoS ONE"},{"issue":"3","key":"3783_CR190","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/S0092-8674(00)80932-0","volume":"92","author":"B van Steensel","year":"1998","unstructured":"van Steensel B, Smogorzewska A, de Lange T (1998) TRF2 protects human telomeres from end-to-end fusions. Cell 92(3):401\u2013413","journal-title":"Cell"},{"issue":"5","key":"3783_CR191","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1128\/MCB.20.5.1659-1668.2000","volume":"20","author":"A Smogorzewska","year":"2000","unstructured":"Smogorzewska A et al (2000) Control of human telomere length by TRF1 and TRF2. Mol Cell Biol 20(5):1659\u20131668","journal-title":"Mol Cell Biol"},{"issue":"2b","key":"3783_CR192","first-page":"1315","volume":"22","author":"K Yamada","year":"2002","unstructured":"Yamada K et al (2002) Decreased gene expression for telomeric-repeat binding factors and TIN2 in malignant hematopoietic cells. Anticancer Res 22(2b):1315\u20131320","journal-title":"Anticancer Res"},{"issue":"6a","key":"3783_CR193","first-page":"3303","volume":"22","author":"M Yamada","year":"2002","unstructured":"Yamada M et al (2002) Down-regulation of TRF1, TRF2 and TIN2 genes is important to maintain telomeric DNA for gastric cancers. Anticancer Res 22(6a):3303\u20133307","journal-title":"Anticancer Res"},{"issue":"1","key":"3783_CR194","doi-asserted-by":"publisher","first-page":"63","DOI":"10.3892\/etm.2010.168","volume":"2","author":"H-C Chuang","year":"2011","unstructured":"Chuang H-C et al (2011) Reduced expression of TRF1 is associated with tumor progression and poor prognosis in oral squamous cell carcinoma. Experim Therapeutic Med 2(1):63\u201367","journal-title":"Experim Therapeutic Med"},{"key":"3783_CR195","doi-asserted-by":"publisher","first-page":"10132","DOI":"10.1038\/ncomms10132","volume":"6","author":"B Nera","year":"2015","unstructured":"Nera B et al (2015) Elevated levels of TRF2 induce telomeric ultrafine anaphase bridges and rapid telomere deletions. Nat Commun 6:10132","journal-title":"Nat Commun"},{"issue":"5564","key":"3783_CR196","doi-asserted-by":"publisher","first-page":"2446","DOI":"10.1126\/science.1069523","volume":"295","author":"J Karlseder","year":"2002","unstructured":"Karlseder J, Smogorzewska A, de Lange T (2002) Senescence induced by altered telomere state, not telomere loss. Science 295(5564):2446\u20132449","journal-title":"Science"},{"issue":"4","key":"3783_CR197","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1038\/embor.2013.16","volume":"14","author":"I Diala","year":"2013","unstructured":"Diala I et al (2013) Telomere protection and TRF2 expression are enhanced by the canonical Wnt signalling pathway. EMBO Rep 14(4):356\u2013363","journal-title":"EMBO Rep"},{"issue":"7","key":"3783_CR198","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1038\/cr.2011.40","volume":"21","author":"T Simonet","year":"2011","unstructured":"Simonet T et al (2011) The human TTAGGG repeat factors 1 and 2 bind to a subset of interstitial telomeric sequences and satellite repeats. Cell Res 21(7):1028\u20131038","journal-title":"Cell Res"},{"issue":"7","key":"3783_CR199","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1038\/cr.2011.39","volume":"21","author":"D Yang","year":"2011","unstructured":"Yang D et al (2011) Human telomeric proteins occupy selective interstitial sites. Cell Res 21(7):1013\u20131027","journal-title":"Cell Res"},{"issue":"7","key":"3783_CR200","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1038\/ncb2774","volume":"15","author":"A Biroccio","year":"2013","unstructured":"Biroccio A et al (2013) TRF2 inhibits a cell-extrinsic pathway through which natural killer cells eliminate cancer cells. Nat Cell Biol 15(7):818\u2013828","journal-title":"Nat Cell Biol"},{"issue":"11","key":"3783_CR201","doi-asserted-by":"publisher","first-page":"e100012","DOI":"10.15252\/embj.2018100012","volume":"38","author":"J Cherfils-Vicini","year":"2019","unstructured":"Cherfils-Vicini J et al (2019) Cancer cells induce immune escape via glycocalyx changes controlled by the telomeric protein TRF2. EMBO J 38(11):e100012","journal-title":"EMBO J"},{"issue":"3","key":"3783_CR202","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1016\/j.celrep.2014.09.038","volume":"9","author":"M El Ma\u00ef","year":"2014","unstructured":"El Ma\u00ef M et al (2014) The Telomeric Protein TRF2 Regulates Angiogenesis by Binding and Activating the PDGFR\u03b2 Promoter. Cell Rep 9(3):1047\u20131060","journal-title":"Cell Rep"},{"issue":"7","key":"3783_CR203","doi-asserted-by":"publisher","first-page":"3365","DOI":"10.1093\/nar\/gkz041","volume":"47","author":"P Zizza","year":"2019","unstructured":"Zizza P et al (2019) TRF2 positively regulates SULF2 expression increasing VEGF-A release and activity in tumor microenvironment. Nucleic Acids Res 47(7):3365\u20133382","journal-title":"Nucleic Acids Res"},{"issue":"22","key":"3783_CR204","doi-asserted-by":"publisher","first-page":"2166","DOI":"10.4161\/cbt.8.22.9880","volume":"8","author":"W Dong","year":"2009","unstructured":"Dong W et al (2009) Sp1 upregulates expression of TRF2 and TRF2 inhibition reduces tumorigenesis in human colorectal carcinoma cells. Cancer Biol Ther 8(22):2166\u20132174","journal-title":"Cancer Biol Ther"},{"issue":"3","key":"3783_CR205","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1007\/s10549-010-0988-7","volume":"127","author":"MC Diehl","year":"2011","unstructured":"Diehl MC et al (2011) Elevated TRF2 in advanced breast cancers with short telomeres. Breast Cancer Res Treat 127(3):623\u2013630","journal-title":"Breast Cancer Res Treat"},{"issue":"10","key":"3783_CR206","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1002\/glia.22708","volume":"62","author":"Y Bai","year":"2014","unstructured":"Bai Y et al (2014) Molecular targeting of TRF2 suppresses the growth and tumorigenesis of glioblastoma stem cells. Glia 62(10):1687\u20131698","journal-title":"Glia"},{"issue":"7","key":"3783_CR207","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/s41389-018-0062-6","volume":"7","author":"S Roy","year":"2018","unstructured":"Roy S et al (2018) p38 MAPK pathway and its interaction with TRF2 in cisplatin induced chemotherapeutic response in head and neck cancer. Oncogenesis 7(7):53","journal-title":"Oncogenesis"},{"issue":"10","key":"3783_CR208","doi-asserted-by":"publisher","first-page":"2007","DOI":"10.1038\/sj.leu.2403086","volume":"17","author":"W Klapper","year":"2003","unstructured":"Klapper W et al (2003) DNA damage transiently increases TRF2 mRNA expression and telomerase activity. Leukemia 17(10):2007\u20132015","journal-title":"Leukemia"},{"issue":"7","key":"3783_CR209","doi-asserted-by":"publisher","first-page":"164","DOI":"10.3390\/v9070164","volume":"9","author":"H Knecht","year":"2017","unstructured":"Knecht H, Mai S (2017) LMP1 and dynamic progressive telomere dysfunction: a major culprit in EBV-associated hodgkin\u2019s lymphoma. Viruses 9(7):164","journal-title":"Viruses"},{"issue":"13","key":"3783_CR210","doi-asserted-by":"publisher","first-page":"2101","DOI":"10.1182\/blood-2014-08-594176","volume":"125","author":"V Lajoie","year":"2015","unstructured":"Lajoie V et al (2015) LMP1 mediates multinuclearity through downregulation of shelterin proteins and formation of telomeric aggregates. Blood 125(13):2101\u20132110","journal-title":"Blood"},{"issue":"3","key":"3783_CR211","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/j.lungcan.2007.11.001","volume":"60","author":"C Fr\u00edas","year":"2008","unstructured":"Fr\u00edas C et al (2008) Telomere shortening is associated with poor prognosis and telomerase activity correlates with DNA repair impairment in non-small cell lung cancer. Lung Cancer 60(3):416\u2013425","journal-title":"Lung Cancer"},{"issue":"10","key":"3783_CR212","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1038\/ng1633","volume":"37","author":"P Mu\u00f1oz","year":"2005","unstructured":"Mu\u00f1oz P et al (2005) XPF nuclease-dependent telomere loss and increased DNA damage in mice overexpressing TRF2 result in premature aging and cancer. Nat Genet 37(10):1063\u20131071","journal-title":"Nat Genet"},{"key":"3783_CR213","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.leukres.2017.05.017","volume":"59","author":"G Ishdorj","year":"2017","unstructured":"Ishdorj G et al (2017) A novel spliced variant of the TIN2 shelterin is present in chronic lymphocytic leukemia. Leuk Res 59:66\u201374","journal-title":"Leuk Res"},{"issue":"42","key":"3783_CR214","doi-asserted-by":"publisher","first-page":"43799","DOI":"10.1074\/jbc.M408650200","volume":"279","author":"SH Kim","year":"2004","unstructured":"Kim SH et al (2004) TIN2 mediates functions of TRF2 at human telomeres. J Biol Chem 279(42):43799\u201343804","journal-title":"J Biol Chem"},{"issue":"5","key":"3783_CR215","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1182\/blood-2010-07-295774","volume":"118","author":"A Augereau","year":"2011","unstructured":"Augereau A et al (2011) Telomeric damage in early stage of chronic lymphocytic leukemia correlates with shelterin dysregulation. Blood 118(5):1316\u20131322","journal-title":"Blood"},{"issue":"6","key":"3783_CR216","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1093\/gerona\/glu019","volume":"70","author":"R Gao","year":"2015","unstructured":"Gao R et al (2015) Targeting of DNA damage signaling pathway induced senescence and reduced migration of cancer cells. J Gerontol A Biol Sci Med Sci 70(6):701\u2013713","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"19","key":"3783_CR217","doi-asserted-by":"publisher","first-page":"4959","DOI":"10.3390\/ijms20194959","volume":"20","author":"P Billard","year":"2019","unstructured":"Billard P, Poncet DA (2019) Replication stress at telomeric and mitochondrial DNA: common origins and consequences on ageing. Int J Mol Sci 20(19):4959","journal-title":"Int J Mol Sci"},{"issue":"6","key":"3783_CR218","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1016\/j.molcel.2012.07.002","volume":"47","author":"LY Chen","year":"2012","unstructured":"Chen LY et al (2012) Mitochondrial localization of telomeric protein TIN2 links telomere regulation to metabolic control. Mol Cell 47(6):839\u2013850","journal-title":"Mol Cell"},{"issue":"8","key":"3783_CR219","doi-asserted-by":"publisher","first-page":"4271","DOI":"10.1093\/nar\/gky223","volume":"46","author":"JH Lee","year":"2018","unstructured":"Lee JH et al (2018) Loss of RNA-binding protein HuR facilitates cellular senescence through posttranscriptional regulation of TIN2 mRNA. Nucleic Acids Res 46(8):4271\u20134285","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"3783_CR220","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1083\/jcb.200710028","volume":"181","author":"S-H Kim","year":"2008","unstructured":"Kim S-H et al (2008) Telomere dysfunction and cell survival: roles for distinct TIN2-containing complexes. J Cell Biol 181(3):447\u2013460","journal-title":"J Cell Biol"},{"issue":"7","key":"3783_CR221","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1038\/sj.embor.embor872","volume":"4","author":"S-H Kim","year":"2003","unstructured":"Kim S-H et al (2003) The human telomere-associated protein TIN2 stimulates interactions between telomeric DNA tracts in vitro. EMBO Rep 4(7):685\u2013691","journal-title":"EMBO Rep"},{"key":"3783_CR222","volume-title":"Biochemical and structural analysis of shelterin subcomplexes","author":"I Oviya","year":"2018","unstructured":"Oviya I (2018) Biochemical and structural analysis of shelterin subcomplexes. Nanyang Technological University, Nanyang"},{"issue":"14","key":"3783_CR223","doi-asserted-by":"publisher","first-page":"10472","DOI":"10.1074\/jbc.M109.098798","volume":"285","author":"S-H Kim","year":"2010","unstructured":"Kim S-H et al (2010) Androgen receptor interacts with telomeric proteins in prostate cancer cells. J Biolog Chem 285(14):10472\u201310476","journal-title":"J Biolog Chem"},{"issue":"3","key":"3783_CR224","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.lungcan.2007.06.019","volume":"58","author":"CP Hsu","year":"2007","unstructured":"Hsu CP et al (2007) Modulation of telomere shelterin by TRF1 [corrected] and TRF2 interacts with telomerase to maintain the telomere length in non-small cell lung cancer. Lung Cancer 58(3):310\u2013316","journal-title":"Lung Cancer"},{"issue":"37","key":"3783_CR225","doi-asserted-by":"publisher","first-page":"39422","DOI":"10.18632\/oncotarget.4964","volume":"6","author":"JA Menendez","year":"2015","unstructured":"Menendez JA et al (2015) Heregulin, a new regulator of telomere length in human cells. Oncotarget 6(37):39422\u201339436","journal-title":"Oncotarget"},{"issue":"27","key":"3783_CR226","doi-asserted-by":"publisher","first-page":"28585","DOI":"10.1074\/jbc.M312913200","volume":"279","author":"MS O'Connor","year":"2004","unstructured":"O\u2019Connor MS et al (2004) The human Rap1 protein complex and modulation of telomere length. J Biol Chem 279(27):28585\u201328591","journal-title":"J Biol Chem"},{"issue":"4","key":"3783_CR227","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1016\/j.celrep.2014.10.014","volume":"9","author":"S Kabir","year":"2014","unstructured":"Kabir S, Hockemeyer D, de Lange T (2014) TALEN gene knockouts reveal no requirement for the conserved human shelterin protein Rap1 in telomere protection and length regulation. Cell Rep 9(4):1273\u20131280","journal-title":"Cell Rep"},{"issue":"5973","key":"3783_CR228","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.1126\/science.1185100","volume":"327","author":"A Sfeir","year":"2010","unstructured":"Sfeir A et al (2010) Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signal. Science 327(5973):1657\u20131661","journal-title":"Science"},{"issue":"4","key":"3783_CR229","doi-asserted-by":"publisher","first-page":"e49076","DOI":"10.15252\/embr.201949076","volume":"21","author":"L Lototska","year":"2020","unstructured":"Lototska L et al (2020) Human RAP1 specifically protects telomeres of senescent cells from DNA damage. EMBO Rep 21(4):e49076","journal-title":"EMBO Rep"},{"issue":"2","key":"3783_CR230","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.molcel.2015.12.009","volume":"61","author":"D Benarroch-Popivker","year":"2016","unstructured":"Benarroch-Popivker D et al (2016) TRF2-mediated control of telomere DNA topology as a mechanism for chromosome-end protection. Mol Cell 61(2):274\u2013286","journal-title":"Mol Cell"},{"issue":"10","key":"3783_CR231","doi-asserted-by":"publisher","first-page":"e0204909","DOI":"10.1371\/journal.pone.0204909","volume":"13","author":"I Ferrara-Romeo","year":"2018","unstructured":"Ferrara-Romeo I, Mart\u00ednez P, Blasco MA (2018) Mice lacking RAP1 show early onset and higher rates of DEN-induced hepatocellular carcinomas in female mice. PLoS ONE 13(10):e0204909","journal-title":"PLoS ONE"},{"issue":"8","key":"3783_CR232","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1038\/ncb2081","volume":"12","author":"P Martinez","year":"2010","unstructured":"Martinez P et al (2010) Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites. Nat Cell Biol 12(8):768\u2013780","journal-title":"Nat Cell Biol"},{"issue":"8","key":"3783_CR233","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1038\/ncb2080","volume":"12","author":"H Teo","year":"2010","unstructured":"Teo H et al (2010) Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression. Nat Cell Biol 12(8):758\u2013767","journal-title":"Nat Cell Biol"},{"key":"3783_CR234","doi-asserted-by":"publisher","first-page":"15007","DOI":"10.1038\/cddiscovery.2015.7","volume":"1","author":"Y Zhang","year":"2015","unstructured":"Zhang Y et al (2015) Rap1-mediated nuclear factor-kappaB (NF-kappaB) activity regulates the paracrine capacity of mesenchymal stem cells in heart repair following infarction. Cell Death Discov 1:15007","journal-title":"Cell Death Discov"},{"issue":"22","key":"3783_CR235","doi-asserted-by":"publisher","first-page":"3580","DOI":"10.1080\/15384101.2015.1100771","volume":"14","author":"Y Cai","year":"2015","unstructured":"Cai Y et al (2015) Rap1 induces cytokine production in pro-inflammatory macrophages through NFkappaB signaling and is highly expressed in human atherosclerotic lesions. Cell Cycle 14(22):3580\u20133592","journal-title":"Cell Cycle"},{"issue":"3","key":"3783_CR236","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1038\/s41419-018-0414-3","volume":"9","author":"Y Ding","year":"2018","unstructured":"Ding Y et al (2018) Rap1 deficiency-provoked paracrine dysfunction impairs immunosuppressive potency of mesenchymal stem cells in allograft rejection of heart transplantation. Cell Death Dis 9(3):386","journal-title":"Cell Death Dis"},{"issue":"2","key":"3783_CR237","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1167\/iovs.14-15268","volume":"56","author":"MW Poon","year":"2015","unstructured":"Poon MW et al (2015) Inhibition of RAP1 enhances corneal recovery following alkali injury. Invest Ophthalmol Vis Sci 56(2):711\u2013721","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"3783_CR238","doi-asserted-by":"publisher","first-page":"5349","DOI":"10.1038\/s41467-019-13082-9","volume":"10","author":"E Khattar","year":"2019","unstructured":"Khattar E et al (2019) Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy. Nature Commun 10(1):5349\u20135349","journal-title":"Nature Commun"},{"issue":"6","key":"3783_CR239","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1080\/09553002.2020.1721609","volume":"96","author":"K Anuja","year":"2020","unstructured":"Anuja K et al (2020) Role of telomeric RAP1 in radiation sensitivity modulation and its interaction with CSC marker KLF4 in colorectal cancer. Int J Radiat Biol 96(6):790\u2013802","journal-title":"Int J Radiat Biol"},{"issue":"4","key":"3783_CR240","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1089\/thy.2011.0109","volume":"22","author":"S Cantara","year":"2012","unstructured":"Cantara S et al (2012) Lack of mutations of the telomerase RNA component in familial papillary thyroid cancer with short telomeres. Thyroid 22(4):363\u2013368","journal-title":"Thyroid"},{"issue":"4","key":"3783_CR241","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1016\/j.jhep.2013.05.011","volume":"59","author":"H Kim","year":"2013","unstructured":"Kim H et al (2013) Telomere length, TERT and shelterin complex proteins in hepatocellular carcinomas expressing \u201cstemness\u201d-related markers. J Hepatol 59(4):746\u2013752","journal-title":"J Hepatol"},{"issue":"7","key":"3783_CR242","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1002\/gcc.22171","volume":"53","author":"M Hoxha","year":"2014","unstructured":"Hoxha M et al (2014) Relevance of telomere\/telomerase system impairment in early stage chronic lymphocytic leukemia. Genes Chromosomes Cancer 53(7):612\u2013621","journal-title":"Genes Chromosomes Cancer"},{"issue":"8","key":"3783_CR243","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1038\/nsmb1270","volume":"14","author":"D Hockemeyer","year":"2007","unstructured":"Hockemeyer D et al (2007) Telomere protection by mammalian Pot1 requires interaction with Tpp1. Nat Struct Mol Biol 14(8):754\u2013761","journal-title":"Nat Struct Mol Biol"},{"issue":"22","key":"3783_CR244","doi-asserted-by":"publisher","first-page":"4709","DOI":"10.1038\/sj.emboj.7601893","volume":"26","author":"X Guo","year":"2007","unstructured":"Guo X et al (2007) Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis. EMBO J 26(22):4709\u20134719","journal-title":"EMBO J"},{"issue":"12","key":"3783_CR245","doi-asserted-by":"publisher","first-page":"2971","DOI":"10.1128\/MCB.00240-10","volume":"30","author":"E Abreu","year":"2010","unstructured":"Abreu E et al (2010) TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo. Mol Cell Biol 30(12):2971\u20132982","journal-title":"Mol Cell Biol"},{"issue":"3","key":"3783_CR246","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/j.cell.2012.07.012","volume":"150","author":"FL Zhong","year":"2012","unstructured":"Zhong FL et al (2012) TPP1 OB-fold domain controls telomere maintenance by recruiting telomerase to chromosome ends. Cell 150(3):481\u2013494","journal-title":"Cell"},{"key":"3783_CR247","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1186\/s12885-015-1639-5","volume":"15","author":"J-F Spinella","year":"2015","unstructured":"Spinella J-F et al (2015) A novel somatic mutation in ACD induces telomere lengthening and apoptosis resistance in leukemia cells. BMC cancer 15:621\u2013621","journal-title":"BMC cancer"},{"key":"3783_CR248","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dju408","author":"LG Aoude","year":"2015","unstructured":"Aoude LG et al (2015) Nonsense mutations in the shelterin complex genes ACD and TERF2IP in familial melanoma. J Natl Cancer Inst. https:\/\/doi.org\/10.1093\/jnci\/dju408","journal-title":"J Natl Cancer Inst"},{"issue":"10","key":"3783_CR249","doi-asserted-by":"publisher","first-page":"2453","DOI":"10.1002\/ijc.31984","volume":"144","author":"TP Potjer","year":"2019","unstructured":"Potjer TP et al (2019) Multigene panel sequencing of established and candidate melanoma susceptibility genes in a large cohort of Dutch non-CDKN2A\/CDK4 melanoma families. Int J Cancer 144(10):2453\u20132464","journal-title":"Int J Cancer"},{"issue":"9","key":"3783_CR250","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1158\/1055-9965.EPI-18-0099","volume":"27","author":"J Li","year":"2018","unstructured":"Li J et al (2018) A rare variant P507L in TPP1 interrupts TPP1-TIN2 interaction, influences telomere length, and confers colorectal cancer risk in chinese population. Cancer Epidemiol Biomarkers Prev 27(9):1029\u20131035","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"11","key":"3783_CR251","doi-asserted-by":"publisher","first-page":"e81034","DOI":"10.1371\/journal.pone.0081034","volume":"8","author":"L Yang","year":"2013","unstructured":"Yang L et al (2013) Telomere-binding protein TPP1 modulates telomere homeostasis and confers radioresistance to human colorectal cancer cells. PLoS ONE 8(11):e81034","journal-title":"PLoS ONE"},{"issue":"1","key":"3783_CR252","doi-asserted-by":"publisher","first-page":"289","DOI":"10.3892\/or.2016.5240","volume":"37","author":"Y Zhao","year":"2017","unstructured":"Zhao Y et al (2017) The transcription factor RFX5 is a transcriptional activator of the TPP1 gene in hepatocellular carcinoma. Oncol Rep 37(1):289\u2013296","journal-title":"Oncol Rep"},{"issue":"6943","key":"3783_CR253","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1038\/nature01688","volume":"423","author":"D Loayza","year":"2003","unstructured":"Loayza D, de Lange T (2003) POT1 as a terminal transducer of TRF1 telomere length control. Nature 423(6943):1013\u20131018","journal-title":"Nature"},{"issue":"2","key":"3783_CR254","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1128\/MCB.25.2.808-818.2005","volume":"25","author":"C Kelleher","year":"2005","unstructured":"Kelleher C, Kurth I, Lingner J (2005) Human protection of telomeres 1 (POT1) is a negative regulator of telomerase activity in vitro. Mol Cell Biol 25(2):808\u2013818","journal-title":"Mol Cell Biol"},{"issue":"1","key":"3783_CR255","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.cell.2006.05.037","volume":"126","author":"L Wu","year":"2006","unstructured":"Wu L et al (2006) Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres. Cell 126(1):49\u201362","journal-title":"Cell"},{"issue":"5","key":"3783_CR256","first-page":"599","volume":"21","author":"K Fujii","year":"2008","unstructured":"Fujii K et al (2008) Protection of telomeres 1 protein levels are associated with telomere length in gastric cancer. Int J Mol Med 21(5):599\u2013604","journal-title":"Int J Mol Med"},{"issue":"2\u20133","key":"3783_CR257","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.bcmd.2013.10.002","volume":"52","author":"J Panero","year":"2014","unstructured":"Panero J et al (2014) Expression profile of shelterin components in plasma cell disorders. Clinical significance of POT1 overexpression. Blood Cells Mol Dis 52(2\u20133):134\u2013139","journal-title":"Blood Cells Mol Dis"},{"issue":"44","key":"3783_CR258","doi-asserted-by":"publisher","first-page":"6941","DOI":"10.3748\/wjg.v11.i44.6941","volume":"11","author":"C-P Hsu","year":"2005","unstructured":"Hsu C-P et al (2005) Clinical significance of telomerase and its associate genes expression in the maintenance of telomere length in squamous cell carcinoma of the esophagus. World J Gastroenterol 11(44):6941\u20136947","journal-title":"World J Gastroenterol"},{"issue":"2","key":"3783_CR259","doi-asserted-by":"publisher","first-page":"359","DOI":"10.3390\/cells9020359","volume":"9","author":"M Amir","year":"2020","unstructured":"Amir M et al (2020) Structural features of nucleoprotein CST\/shelterin complex involved in the telomere maintenance and its association with disease mutations. Cells 9(2):359","journal-title":"Cells"},{"issue":"5","key":"3783_CR260","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1038\/ng.2584","volume":"45","author":"AJ Ramsay","year":"2013","unstructured":"Ramsay AJ et al (2013) POT1 mutations cause telomere dysfunction in chronic lymphocytic leukemia. Nat Genet 45(5):526\u2013530","journal-title":"Nat Genet"},{"issue":"19","key":"3783_CR261","doi-asserted-by":"publisher","first-page":"2319","DOI":"10.1182\/blood-2016-01-695692","volume":"128","author":"HE Speedy","year":"2016","unstructured":"Speedy HE et al (2016) Germ line mutations in shelterin complex genes are associated with familial chronic lymphocytic leukemia. Blood 128(19):2319\u20132326","journal-title":"Blood"},{"issue":"5","key":"3783_CR262","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1038\/ng.2947","volume":"46","author":"CD Robles-Espinoza","year":"2014","unstructured":"Robles-Espinoza CD et al (2014) POT1 loss-of-function variants predispose to familial melanoma. Nat Genet 46(5):478\u2013481","journal-title":"Nat Genet"},{"issue":"5","key":"3783_CR263","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1001\/jamadermatol.2018.3662","volume":"155","author":"K Wong","year":"2019","unstructured":"Wong K et al (2019) Association of the POT1 germline missense variant p.I78T with familial melanoma. JAMA Dermatol 155(5):604\u2013609","journal-title":"JAMA Dermatol"},{"issue":"1","key":"3783_CR264","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s10549-007-9622-8","volume":"109","author":"M Salhab","year":"2008","unstructured":"Salhab M et al (2008) The expression of gene transcripts of telomere-associated genes in human breast cancer: correlation with clinico-pathological parameters and clinical outcome. Breast Cancer Res Treat 109(1):35\u201346","journal-title":"Breast Cancer Res Treat"},{"issue":"6","key":"3783_CR265","doi-asserted-by":"publisher","first-page":"e0197154","DOI":"10.1371\/journal.pone.0197154","volume":"13","author":"F Aljarbou","year":"2018","unstructured":"Aljarbou F et al (2018) The expression of telomere-related proteins and DNA damage response and their association with telomere length in colorectal cancer in Saudi patients. PLoS ONE 13(6):e0197154","journal-title":"PLoS ONE"},{"issue":"2","key":"3783_CR266","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1158\/0008-5472.CAN-03-1196","volume":"64","author":"T Kondo","year":"2004","unstructured":"Kondo T et al (2004) Expression of POT1 is associated with tumor stage and telomere length in gastric carcinoma. Cancer Res 64(2):523\u2013529","journal-title":"Cancer Res"},{"issue":"1","key":"3783_CR267","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1007\/s12035-012-8363-9","volume":"47","author":"S Ferrandon","year":"2013","unstructured":"Ferrandon S et al (2013) Telomere profiling: toward glioblastoma personalized medicine. Mol Neurobiol 47(1):64\u201376","journal-title":"Mol Neurobiol"},{"issue":"2","key":"3783_CR268","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1111\/j.1365-2141.2008.07176.x","volume":"142","author":"F Vega","year":"2008","unstructured":"Vega F et al (2008) Splenic marginal zone lymphomas are characterized by loss of interstitial regions of chromosome 7q, 7q31.32 and 7q36.2 that include the protection of telomere 1 (POT1) and sonic hedgehog (SHH) genes. Br J Haematol 142(2):216\u2013226","journal-title":"Br J Haematol"},{"issue":"11\u201312","key":"3783_CR269","doi-asserted-by":"publisher","first-page":"471","DOI":"10.2119\/molmed.2010.00057","volume":"16","author":"J Panero","year":"2010","unstructured":"Panero J et al (2010) Altered mRNA expression of telomere-associated genes in monoclonal gammopathy of undetermined significance and multiple myeloma. Mol Med 16(11\u201312):471\u2013478","journal-title":"Mol Med"},{"key":"3783_CR270","doi-asserted-by":"crossref","unstructured":"Bernardes de Jesus B et al (2012) Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer. EMBO Mol Med 4(8): 691\u2013704","DOI":"10.1002\/emmm.201200245"},{"issue":"3","key":"3783_CR271","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1007\/s10549-014-2975-x","volume":"145","author":"A Motevalli","year":"2014","unstructured":"Motevalli A et al (2014) The effect of chemotherapeutic agents on telomere length maintenance in breast cancer cell lines. Breast Cancer Res Treat 145(3):581\u2013591","journal-title":"Breast Cancer Res Treat"},{"key":"3783_CR272","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12040949","author":"M Recagni","year":"2020","unstructured":"Recagni M et al (2020) The role of alternative lengthening of telomeres mechanism in cancer: translational and therapeutic implications. Cancers (Basel). https:\/\/doi.org\/10.3390\/cancers12040949","journal-title":"Cancers (Basel)"},{"issue":"11","key":"3783_CR273","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1038\/nm1197-1271","volume":"3","author":"TM Bryan","year":"1997","unstructured":"Bryan TM et al (1997) Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines. Nat Med 3(11):1271\u20131274","journal-title":"Nat Med"},{"issue":"17","key":"3783_CR274","doi-asserted-by":"publisher","first-page":"4240","DOI":"10.1002\/j.1460-2075.1995.tb00098.x","volume":"14","author":"TM Bryan","year":"1995","unstructured":"Bryan TM et al (1995) Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J 14(17):4240\u20134248","journal-title":"EMBO J"},{"issue":"4","key":"3783_CR275","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1038\/82586","volume":"26","author":"MA Dunham","year":"2000","unstructured":"Dunham MA et al (2000) Telomere maintenance by recombination in human cells. Nat Genet 26(4):447\u2013450","journal-title":"Nat Genet"}],"container-title":["Cellular and Molecular Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-021-03783-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00018-021-03783-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-021-03783-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T09:26:03Z","timestamp":1628241963000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00018-021-03783-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,18]]},"references-count":275,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["3783"],"URL":"https:\/\/doi.org\/10.1007\/s00018-021-03783-0","relation":{},"ISSN":["1420-682X","1420-9071"],"issn-type":[{"value":"1420-682X","type":"print"},{"value":"1420-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,18]]},"assertion":[{"value":"5 August 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 December 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 January 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 February 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}