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Indeed, many of the genetic risk variants cluster in genes of the alternative pathway of the complement system and complement activation products are elevated in AMD patients. Nevertheless, attempts in treating AMD via complement regulators have not yet been successful, suggesting a level of complexity that could not be predicted only from a genetic point of view. In this review, we will explore the role of complement system in AMD development and in the main molecular and cellular features of AMD, including complement activation itself, inflammation, ECM stability, energy metabolism and oxidative stress.<\/jats:p>","DOI":"10.1007\/s00018-021-03796-9","type":"journal-article","created":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T14:03:18Z","timestamp":1615298598000},"page":"4487-4505","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":270,"title":["The complement system in age-related macular degeneration"],"prefix":"10.1007","volume":"78","author":[{"given":"Angela","family":"Armento","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"Ueffing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8394-8355","authenticated-orcid":false,"given":"Simon J.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,9]]},"reference":[{"issue":"2","key":"3796_CR1","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1002\/path.4266","volume":"232","author":"M van Lookeren Campagne","year":"2014","unstructured":"van Lookeren Campagne M et al (2014) Mechanisms of age-related macular degeneration and therapeutic opportunities. 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