{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T21:44:33Z","timestamp":1778103873496,"version":"3.51.4"},"reference-count":82,"publisher":"Springer Science and Business Media LLC","issue":"23","license":[{"start":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T00:00:00Z","timestamp":1634515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T00:00:00Z","timestamp":1634515200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000874","name":"Brain and Behavior Research Foundation","doi-asserted-by":"publisher","award":["20748"],"award-info":[{"award-number":["20748"]}],"id":[{"id":"10.13039\/100000874","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Wilhelm Schuler-Stiftung"},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["445878942"],"award-info":[{"award-number":["445878942"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["354137032"],"award-info":[{"award-number":["354137032"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GRK2381"],"award-info":[{"award-number":["GRK2381"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Robert Pfleger Stiftung"},{"DOI":"10.13039\/501100002345","name":"Eberhard Karls Universit\u00e4t T\u00fcbingen","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002345","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell. Mol. Life Sci."],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human mutations of the Na<jats:sup>+<\/jats:sup>-activated K<jats:sup>+<\/jats:sup> channel Slack (<jats:italic>KCNT1<\/jats:italic>) are associated with epilepsy and intellectual disability. Accordingly, Slack knockout mice (<jats:italic>Slack<\/jats:italic><jats:sup><jats:italic>\u2212\/\u2212<\/jats:italic><\/jats:sup>) exhibit cognitive flexibility deficits in distinct behavioral tasks. So far, however, the underlying causes as well as the role of Slack in hippocampus-dependent memory functions remain enigmatic. We now report that infant (P6\u2013P14) <jats:italic>Slack<\/jats:italic><jats:sup><jats:italic>\u2212\/\u2212<\/jats:italic><\/jats:sup> lack both hippocampal LTD and LTP, likely due to impaired NMDA receptor (NMDAR) signaling. Postsynaptic GluN2B levels are reduced in infant <jats:italic>Slack<\/jats:italic><jats:sup><jats:italic>\u2212\/\u2212<\/jats:italic><\/jats:sup>, evidenced by lower amplitudes of NMDAR-meditated excitatory postsynaptic potentials. Low GluN2B affected NMDAR-mediated Ca<jats:sup>2+<\/jats:sup>-influx, rendering cultured hippocampal <jats:italic>Slack<\/jats:italic><jats:sup><jats:italic>\u2212\/\u2212<\/jats:italic><\/jats:sup>neurons highly insensitive to the GluN2B-specific inhibitor Ro 25-6981. Furthermore, dephosphorylation of the AMPA receptor (AMPAR) subunit GluA1 at S845, which is involved in AMPAR endocytosis during homeostatic and neuromodulator-regulated plasticity, is reduced after chemical LTD (cLTD) in infant <jats:italic>Slack<\/jats:italic><jats:sup><jats:italic>\u2212\/\u2212<\/jats:italic><\/jats:sup>. We additionally detect a lack of mGluR-induced LTD in infant <jats:italic>Slack<\/jats:italic><jats:sup><jats:italic>\u2212\/\u2212<\/jats:italic><\/jats:sup>, possibly caused by upregulation of the recycling endosome-associated small GTPase Rab4 which might accelerate AMPAR recycling from early endosomes. Interestingly, LTP and mGluR LTD, but not LTD and S845 dephosphorylation after cLTD are restored in adult <jats:italic>Slack<\/jats:italic><jats:sup><jats:italic>\u2212\/\u2212<\/jats:italic><\/jats:sup>. This together with normalized expression levels of GluN2B and Rab4 hints to developmental \u201crestoration\u201d of LTP expression despite Slack ablation, whereas in infant and adult brain, NMDAR-dependent LTD induction depends on this channel. Based on the present findings, NMDAR and vesicular transport might represent novel targets for the therapy of intellectual disability associated with Slack mutations. Consequently, careful modulation of hippocampal Slack activity should also improve learning abilities.<\/jats:p>","DOI":"10.1007\/s00018-021-03953-0","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T14:27:15Z","timestamp":1635172035000},"page":"7569-7587","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The Na+-activated K+ channel Slack contributes to synaptic development and plasticity"],"prefix":"10.1007","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3235-5140","authenticated-orcid":false,"given":"Lucas","family":"Matt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Pham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Skrabak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Eckert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaqi","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Gisevius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebekka","family":"Ehinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Bausch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marius","family":"Ueffing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karsten","family":"Boldt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Ruth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Lukowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,10,18]]},"reference":[{"issue":"2","key":"3953_CR1","first-page":"1","volume":"62","author":"R Perou","year":"2013","unstructured":"Perou R, Bitsko RH, Blumberg SJ, Pastor P, Ghandour RM, Gfroerer JC, Hedden SL, Crosby AE, Visser SN, Schieve LA, Parks SE, Hall JE, Brody D, Simile CM, Thompson WW, Baio J, Avenevoli S, Kogan MD, Huang LN, Centers for Disease C, Prevention (2013) Mental health surveillance among children\u2013United States, 2005\u20132011. MMWR Suppl 62(2):1\u201335","journal-title":"MMWR Suppl"},{"issue":"Pt 2","key":"3953_CR2","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.neubiorev.2014.02.015","volume":"46","author":"AK Srivastava","year":"2014","unstructured":"Srivastava AK, Schwartz CE (2014) Intellectual disability and autism spectrum disorders: causal genes and molecular mechanisms. Neurosci Biobehav Rev 46(Pt 2):161\u2013174. https:\/\/doi.org\/10.1016\/j.neubiorev.2014.02.015","journal-title":"Neurosci Biobehav Rev"},{"issue":"4","key":"3953_CR3","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1136\/jmedgenet-2015-103508","volume":"53","author":"CX Lim","year":"2016","unstructured":"Lim CX, Ricos MG, Dibbens LM, Heron SE (2016) KCNT1 mutations in seizure disorders: the phenotypic spectrum and functional effects. J Med Genet 53(4):217\u2013225. https:\/\/doi.org\/10.1136\/jmedgenet-2015-103508","journal-title":"J Med Genet"},{"issue":"1","key":"3953_CR4","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1096\/fj.201902366R","volume":"34","author":"SR Ali","year":"2020","unstructured":"Ali SR, Malone TJ, Zhang Y, Prechova M, Kaczmarek LK (2020) Phactr1 regulates Slack (KCNT1) channels via protein phosphatase 1 (PP1). FASEB J 34(1):1591\u20131601. https:\/\/doi.org\/10.1096\/fj.201902366R","journal-title":"FASEB J"},{"issue":"7","key":"3953_CR5","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1101\/lm.037820.114","volume":"22","author":"AE Bausch","year":"2015","unstructured":"Bausch AE, Dieter R, Nann Y, Hausmann M, Meyerdierks N, Kaczmarek LK, Ruth P, Lukowski R (2015) The sodium-activated potassium channel Slack is required for optimal cognitive flexibility in mice. Learn Mem 22(7):323\u2013335. https:\/\/doi.org\/10.1101\/lm.037820.114","journal-title":"Learn Mem"},{"key":"3953_CR6","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3389\/fncel.2014.00209","volume":"8","author":"GE Kim","year":"2014","unstructured":"Kim GE, Kaczmarek LK (2014) Emerging role of the KCNT1 Slack channel in intellectual disability. Front Cell Neurosci 8:209. https:\/\/doi.org\/10.3389\/fncel.2014.00209","journal-title":"Front Cell Neurosci"},{"issue":"11","key":"3953_CR7","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1038\/ng.2440","volume":"44","author":"SE Heron","year":"2012","unstructured":"Heron SE, Smith KR, Bahlo M, Nobili L, Kahana E, Licchetta L, Oliver KL, Mazarib A, Afawi Z, Korczyn A, Plazzi G, Petrou S, Berkovic SF, Scheffer IE, Dibbens LM (2012) Missense mutations in the sodium-gated potassium channel gene KCNT1 cause severe autosomal dominant nocturnal frontal lobe epilepsy. Nat Genet 44(11):1188\u20131190. https:\/\/doi.org\/10.1038\/ng.2440","journal-title":"Nat Genet"},{"issue":"1","key":"3953_CR8","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.pediatrneurol.2013.06.024","volume":"50","author":"A Vanderver","year":"2014","unstructured":"Vanderver A, Simons C, Schmidt JL, Pearl PL, Bloom M, Lavenstein B, Miller D, Grimmond SM, Taft RJ (2014) Identification of a novel de novo p.Phe932Ile KCNT1 mutation in a patient with leukoencephalopathy and severe epilepsy. Pediatr Neurol 50(1):112\u2013114. https:\/\/doi.org\/10.1016\/j.pediatrneurol.2013.06.024","journal-title":"Pediatr Neurol"},{"key":"3953_CR9","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.neuroscience.2017.03.035","volume":"351","author":"KM Evely","year":"2017","unstructured":"Evely KM, Pryce KD, Bhattacharjee A (2017) The Phe932Ile mutation in KCNT1 channels associated with severe epilepsy, delayed myelination and leukoencephalopathy produces a loss-of-function channel phenotype. Neuroscience 351:65\u201370. https:\/\/doi.org\/10.1016\/j.neuroscience.2017.03.035","journal-title":"Neuroscience"},{"issue":"11","key":"3953_CR10","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1038\/ng.2441","volume":"44","author":"G Barcia","year":"2012","unstructured":"Barcia G, Fleming MR, Deligniere A, Gazula VR, Brown MR, Langouet M, Chen H, Kronengold J, Abhyankar A, Cilio R, Nitschke P, Kaminska A, Boddaert N, Casanova JL, Desguerre I, Munnich A, Dulac O, Kaczmarek LK, Colleaux L, Nabbout R (2012) De novo gain-of-function KCNT1 channel mutations cause malignant migrating partial seizures of infancy. Nat Genet 44(11):1255\u20131259. https:\/\/doi.org\/10.1038\/ng.2441","journal-title":"Nat Genet"},{"issue":"5","key":"3953_CR11","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.1016\/j.celrep.2014.11.015","volume":"9","author":"GE Kim","year":"2014","unstructured":"Kim GE, Kronengold J, Barcia G, Quraishi IH, Martin HC, Blair E, Taylor JC, Dulac O, Colleaux L, Nabbout R, Kaczmarek LK (2014) Human slack potassium channel mutations increase positive cooperativity between individual channels. Cell Rep 9(5):1661\u20131672. https:\/\/doi.org\/10.1016\/j.celrep.2014.11.015","journal-title":"Cell Rep"},{"issue":"3","key":"3953_CR12","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1002\/cne.10439","volume":"454","author":"A Bhattacharjee","year":"2002","unstructured":"Bhattacharjee A, Gan L, Kaczmarek LK (2002) Localization of the Slack potassium channel in the rat central nervous system. J Comp Neurol 454(3):241\u2013254. https:\/\/doi.org\/10.1002\/cne.10439","journal-title":"J Comp Neurol"},{"issue":"1","key":"3953_CR13","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1002\/cne.20462","volume":"484","author":"A Bhattacharjee","year":"2005","unstructured":"Bhattacharjee A, von Hehn CA, Mei X, Kaczmarek LK (2005) Localization of the Na+-activated K+ channel Slick in the rat central nervous system. J Comp Neurol 484(1):80\u201392. https:\/\/doi.org\/10.1002\/cne.20462","journal-title":"J Comp Neurol"},{"issue":"10","key":"3953_CR14","doi-asserted-by":"publisher","first-page":"2093","DOI":"10.1002\/cne.23934","volume":"524","author":"S Rizzi","year":"2016","unstructured":"Rizzi S, Knaus HG, Schwarzer C (2016) Differential distribution of the sodium-activated potassium channels slick and slack in mouse brain. J Comp Neurol 524(10):2093\u20132116. https:\/\/doi.org\/10.1002\/cne.23934","journal-title":"J Comp Neurol"},{"key":"3953_CR15","doi-asserted-by":"publisher","first-page":"174480691771434","DOI":"10.1177\/1744806917714342","volume":"13","author":"KM Evely","year":"2017","unstructured":"Evely KM, Pryce KD, Bausch AE, Lukowski R, Ruth P, Haj-Dahmane S, Bhattacharjee A (2017) Slack KNa channels influence dorsal horn synapses and nociceptive behavior. Mol Pain 13:1744806917714342. https:\/\/doi.org\/10.1177\/1744806917714342","journal-title":"Mol Pain"},{"issue":"3","key":"3953_CR16","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1523\/JNEUROSCI.2423-14.2015","volume":"35","author":"R Lu","year":"2015","unstructured":"Lu R, Bausch AE, Kallenborn-Gerhardt W, Stoetzer C, Debruin N, Ruth P, Geisslinger G, Leffler A, Lukowski R, Schmidtko A (2015) Slack channels expressed in sensory neurons control neuropathic pain in mice. J Neurosci 35(3):1125\u20131135. https:\/\/doi.org\/10.1523\/JNEUROSCI.2423-14.2015","journal-title":"J Neurosci"},{"key":"3953_CR17","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.10013","author":"PL Martinez-Espinosa","year":"2015","unstructured":"Martinez-Espinosa PL, Wu J, Yang C, Gonzalez-Perez V, Zhou H, Liang H, Xia XM, Lingle CJ (2015) Knockout of Slo2.2 enhances itch, abolishes KNa current, and increases action potential firing frequency in DRG neurons. Elife. https:\/\/doi.org\/10.7554\/eLife.10013","journal-title":"Elife"},{"issue":"8","key":"3953_CR18","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1016\/j.tins.2005.06.003","volume":"28","author":"A Bhattacharjee","year":"2005","unstructured":"Bhattacharjee A, Kaczmarek LK (2005) For K+ channels, Na+ is the new Ca2+. Trends Neurosci 28(8):422\u2013428. https:\/\/doi.org\/10.1016\/j.tins.2005.06.003","journal-title":"Trends Neurosci"},{"key":"3953_CR19","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/354262","author":"LK Kaczmarek","year":"2013","unstructured":"Kaczmarek LK (2013) Slack, Slick and sodium-activated potassium channels. ISRN Neurosci. https:\/\/doi.org\/10.1155\/2013\/354262","journal-title":"ISRN Neurosci"},{"issue":"1","key":"3953_CR20","doi-asserted-by":"publisher","first-page":"3213","DOI":"10.1038\/s41598-020-60028-z","volume":"10","author":"IH Quraishi","year":"2020","unstructured":"Quraishi IH, Mercier MR, McClure H, Couture RL, Schwartz ML, Lukowski R, Ruth P, Kaczmarek LK (2020) Impaired motor skill learning and altered seizure susceptibility in mice with loss or gain of function of the Kcnt1 gene encoding Slack (KNa1.1) Na(+)-activated K(+) channels. Sci Rep 10(1):3213. https:\/\/doi.org\/10.1038\/s41598-020-60028-z","journal-title":"Sci Rep"},{"issue":"1","key":"3953_CR21","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1038\/sj.npp.1301559","volume":"33","author":"A Citri","year":"2008","unstructured":"Citri A, Malenka RC (2008) Synaptic plasticity: multiple forms, functions, and mechanisms. Neuropsychopharmacology 33(1):18\u201341. https:\/\/doi.org\/10.1038\/sj.npp.1301559","journal-title":"Neuropsychopharmacology"},{"issue":"4","key":"3953_CR22","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.neuron.2010.09.024","volume":"68","author":"KD Micheva","year":"2010","unstructured":"Micheva KD, Busse B, Weiler NC, O\u2019Rourke N, Smith SJ (2010) Single-synapse analysis of a diverse synapse population: proteomic imaging methods and markers. Neuron 68(4):639\u2013653. https:\/\/doi.org\/10.1016\/j.neuron.2010.09.024","journal-title":"Neuron"},{"issue":"2","key":"3953_CR23","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.neuron.2018.10.018","volume":"100","author":"GH Diering","year":"2018","unstructured":"Diering GH, Huganir RL (2018) The AMPA receptor code of synaptic plasticity. Neuron 100(2):314\u2013329. https:\/\/doi.org\/10.1016\/j.neuron.2018.10.018","journal-title":"Neuron"},{"key":"3953_CR24","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1146\/annurev-neuro-071714-033821","volume":"38","author":"L Volk","year":"2015","unstructured":"Volk L, Chiu SL, Sharma K, Huganir RL (2015) Glutamate synapses in human cognitive disorders. Annu Rev Neurosci 38:127\u2013149. https:\/\/doi.org\/10.1146\/annurev-neuro-071714-033821","journal-title":"Annu Rev Neurosci"},{"issue":"1633","key":"3953_CR25","doi-asserted-by":"publisher","first-page":"20130288","DOI":"10.1098\/rstb.2013.0288","volume":"369","author":"T Takeuchi","year":"2014","unstructured":"Takeuchi T, Duszkiewicz AJ, Morris RG (2014) The synaptic plasticity and memory hypothesis: encoding, storage and persistence. Philos Trans R Soc Lond B Biol Sci 369(1633):20130288. https:\/\/doi.org\/10.1098\/rstb.2013.0288","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"issue":"11","key":"3953_CR26","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.1038\/nn.4661","volume":"20","author":"J Lisman","year":"2017","unstructured":"Lisman J, Buzsaki G, Eichenbaum H, Nadel L, Ranganath C, Redish AD (2017) Viewpoints: how the hippocampus contributes to memory, navigation and cognition. Nat Neurosci 20(11):1434\u20131447. https:\/\/doi.org\/10.1038\/nn.4661","journal-title":"Nat Neurosci"},{"issue":"4","key":"3953_CR27","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1523\/JNEUROSCI.23-04-01119.2003","volume":"23","author":"JH Kim","year":"2003","unstructured":"Kim JH, Lee HK, Takamiya K, Huganir RL (2003) The role of synaptic GTPase-activating protein in neuronal development and synaptic plasticity. J Neurosci 23(4):1119\u20131124","journal-title":"J Neurosci"},{"issue":"22","key":"3953_CR28","doi-asserted-by":"publisher","first-page":"9721","DOI":"10.1523\/JNEUROSCI.22-22-09721.2002","volume":"22","author":"NH Komiyama","year":"2002","unstructured":"Komiyama NH, Watabe AM, Carlisle HJ, Porter K, Charlesworth P, Monti J, Strathdee DJ, O\u2019Carroll CM, Martin SJ, Morris RG, O\u2019Dell TJ, Grant SG (2002) SynGAP regulates ERK\/MAPK signaling, synaptic plasticity, and learning in the complex with postsynaptic density 95 and NMDA receptor. J Neurosci 22(22):9721\u20139732","journal-title":"J Neurosci"},{"issue":"11","key":"3953_CR29","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1101\/gad.1783809","volume":"23","author":"N Nadif Kasri","year":"2009","unstructured":"Nadif Kasri N, Nakano-Kobayashi A, Malinow R, Li B, Van Aelst L (2009) The Rho-linked mental retardation protein oligophrenin-1 controls synapse maturation and plasticity by stabilizing AMPA receptors. Genes Dev 23(11):1289\u20131302. https:\/\/doi.org\/10.1101\/gad.1783809","journal-title":"Genes Dev"},{"issue":"2","key":"3953_CR30","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/j.neuron.2011.09.001","volume":"72","author":"N Nadif Kasri","year":"2011","unstructured":"Nadif Kasri N, Nakano-Kobayashi A, Van Aelst L (2011) Rapid synthesis of the X-linked mental retardation protein OPHN1 mediates mGluR-dependent LTD through interaction with the endocytic machinery. Neuron 72(2):300\u2013315. https:\/\/doi.org\/10.1016\/j.neuron.2011.09.001","journal-title":"Neuron"},{"key":"3953_CR31","doi-asserted-by":"publisher","first-page":"260","DOI":"10.3389\/fnmol.2018.00260","volume":"11","author":"L Matt","year":"2018","unstructured":"Matt L, Eckert P, Panford-Walsh R, Geisler HS, Bausch AE, Manthey M, Muller NIC, Harasztosi C, Rohbock K, Ruth P, Friauf E, Ott T, Zimmermann U, Ruttiger L, Schimmang T, Knipper M, Singer W (2018) Visualizing BDNF transcript usage during sound-induced memory linked plasticity. Front Mol Neurosci 11:260. https:\/\/doi.org\/10.3389\/fnmol.2018.00260","journal-title":"Front Mol Neurosci"},{"issue":"1","key":"3953_CR32","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/s00018-010-0446-z","volume":"68","author":"L Matt","year":"2011","unstructured":"Matt L, Michalakis S, Hofmann F, Hammelmann V, Ludwig A, Biel M, Kleppisch T (2011) HCN2 channels in local inhibitory interneurons constrain LTP in the hippocampal direct perforant path. Cell Mol Life Sci 68(1):125\u2013137. https:\/\/doi.org\/10.1007\/s00018-010-0446-z","journal-title":"Cell Mol Life Sci"},{"issue":"7","key":"3953_CR33","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/nmeth.2089","volume":"9","author":"CA Schneider","year":"2012","unstructured":"Schneider CA, Rasband WS, Eliceiri KW (2012) NIH Image to ImageJ: 25 years of image analysis. Nat Methods 9(7):671\u2013675","journal-title":"Nat Methods"},{"key":"3953_CR34","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.neuroscience.2018.05.040","volume":"384","author":"AE Bausch","year":"2018","unstructured":"Bausch AE, Ehinger R, Straubinger J, Zerfass P, Nann Y, Lukowski R (2018) Loss of sodium-activated potassium channel slack and FMRP differentially affect social behavior in mice. Neuroscience 384:361\u2013374. https:\/\/doi.org\/10.1016\/j.neuroscience.2018.05.040","journal-title":"Neuroscience"},{"key":"3953_CR35","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0130-16.2016","author":"G Chenaux","year":"2016","unstructured":"Chenaux G, Matt L, Hill TC, Kaur I, Liu XB, Kirk LM, Speca DJ, McMahon SA, Zito K, Hell JW, Diaz E (2016) Loss of SynDIG1 reduces excitatory synapse maturation but not formation in vivo. eNeuro. https:\/\/doi.org\/10.1523\/ENEURO.0130-16.2016","journal-title":"eNeuro"},{"issue":"9","key":"3953_CR36","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1038\/nprot.2012.099","volume":"7","author":"GM Beaudoin 3rd","year":"2012","unstructured":"Beaudoin GM 3rd, Lee SH, Singh D, Yuan Y, Ng YG, Reichardt LF, Arikkath J (2012) Culturing pyramidal neurons from the early postnatal mouse hippocampus and cortex. Nat Protoc 7(9):1741\u20131754. https:\/\/doi.org\/10.1038\/nprot.2012.099","journal-title":"Nat Protoc"},{"issue":"Unit19","key":"3953_CR37","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1002\/0471140864.ps1920s57","volume":"19","author":"CJ Gloeckner","year":"2009","unstructured":"Gloeckner CJ, Boldt K, Ueffing M (2009) Strep\/FLAG tandem affinity purification (SF-TAP) to study protein interactions. Curr Protoc Protein Sci Chapter 19(Unit19):20. https:\/\/doi.org\/10.1002\/0471140864.ps1920s57","journal-title":"Curr Protoc Protein Sci Chapter"},{"issue":"12","key":"3953_CR38","doi-asserted-by":"publisher","first-page":"2010","DOI":"10.1074\/mcp.T500030-MCP200","volume":"4","author":"JV Olsen","year":"2005","unstructured":"Olsen JV, de Godoy LM, Li G, Macek B, Mortensen P, Pesch R, Makarov A, Lange O, Horning S, Mann M (2005) Parts per million mass accuracy on an Orbitrap mass spectrometer via lock mass injection into a C-trap. Mol Cell Proteomics 4(12):2010\u20132021. https:\/\/doi.org\/10.1074\/mcp.T500030-MCP200","journal-title":"Mol Cell Proteomics"},{"issue":"12","key":"3953_CR39","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1038\/nbt.1511","volume":"26","author":"J Cox","year":"2008","unstructured":"Cox J, Mann M (2008) MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. Nat Biotechnol 26(12):1367\u20131372. https:\/\/doi.org\/10.1038\/nbt.1511","journal-title":"Nat Biotechnol"},{"issue":"5","key":"3953_CR40","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1038\/nprot.2009.36","volume":"4","author":"J Cox","year":"2009","unstructured":"Cox J, Matic I, Hilger M, Nagaraj N, Selbach M, Olsen JV, Mann M (2009) A practical guide to the MaxQuant computational platform for SILAC-based quantitative proteomics. Nat Protoc 4(5):698\u2013705. https:\/\/doi.org\/10.1038\/nprot.2009.36","journal-title":"Nat Protoc"},{"issue":"9","key":"3953_CR41","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1038\/nmeth.3901","volume":"13","author":"S Tyanova","year":"2016","unstructured":"Tyanova S, Temu T, Sinitcyn P, Carlson A, Hein MY, Geiger T, Mann M, Cox J (2016) The Perseus computational platform for comprehensive analysis of (prote)omics data. Nat Methods 13(9):731\u2013740. https:\/\/doi.org\/10.1038\/nmeth.3901","journal-title":"Nat Methods"},{"issue":"1","key":"3953_CR42","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.neuron.2008.01.039","volume":"58","author":"RE Nicholls","year":"2008","unstructured":"Nicholls RE, Alarcon JM, Malleret G, Carroll RC, Grody M, Vronskaya S, Kandel ER (2008) Transgenic mice lacking NMDAR-dependent LTD exhibit deficits in behavioral flexibility. Neuron 58(1):104\u2013117. https:\/\/doi.org\/10.1016\/j.neuron.2008.01.039","journal-title":"Neuron"},{"issue":"7","key":"3953_CR43","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1038\/nrn2867","volume":"11","author":"GL Collingridge","year":"2010","unstructured":"Collingridge GL, Peineau S, Howland JG, Wang YT (2010) Long-term depression in the CNS. Nat Rev Neurosci 11(7):459\u2013473. https:\/\/doi.org\/10.1038\/nrn2867","journal-title":"Nat Rev Neurosci"},{"issue":"7","key":"3953_CR44","doi-asserted-by":"publisher","first-page":"2910","DOI":"10.1523\/JNEUROSCI.13-07-02910.1993","volume":"13","author":"SM Dudek","year":"1993","unstructured":"Dudek SM, Bear MF (1993) Bidirectional long-term modification of synaptic effectiveness in the adult and immature hippocampus. J Neurosci 13(7):2910\u20132918","journal-title":"J Neurosci"},{"issue":"1","key":"3953_CR45","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1046\/j.1460-9568.2000.00903.x","volume":"12","author":"N Kemp","year":"2000","unstructured":"Kemp N, McQueen J, Faulkes S, Bashir ZI (2000) Different forms of LTD in the CA1 region of the hippocampus: role of age and stimulus protocol. Eur J Neurosci 12(1):360\u2013366. https:\/\/doi.org\/10.1046\/j.1460-9568.2000.00903.x","journal-title":"Eur J Neurosci"},{"issue":"24","key":"3953_CR46","doi-asserted-by":"publisher","first-page":"eaba1430","DOI":"10.1126\/sciadv.aba1430","volume":"6","author":"Y Murata","year":"2020","unstructured":"Murata Y, Colonnese MT (2020) GABAergic interneurons excite neonatal hippocampus in vivo. Sci Adv 6(24):eaba1430. https:\/\/doi.org\/10.1126\/sciadv.aba1430","journal-title":"Sci Adv"},{"issue":"6056","key":"3953_CR47","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1038\/319774a0","volume":"319","author":"RG Morris","year":"1986","unstructured":"Morris RG, Anderson E, Lynch GS, Baudry M (1986) Selective impairment of learning and blockade of long-term potentiation by an N-methyl-d-aspartate receptor antagonist, AP5. Nature 319(6056):774\u2013776. https:\/\/doi.org\/10.1038\/319774a0","journal-title":"Nature"},{"issue":"1","key":"3953_CR48","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.mcn.2012.03.005","volume":"50","author":"VA Kulkarni","year":"2012","unstructured":"Kulkarni VA, Firestein BL (2012) The dendritic tree and brain disorders. Mol Cell Neurosci 50(1):10\u201320. https:\/\/doi.org\/10.1016\/j.mcn.2012.03.005","journal-title":"Mol Cell Neurosci"},{"issue":"Suppl 2","key":"3953_CR49","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1111\/j.1601-183X.2006.00224.x","volume":"5","author":"M Dierssen","year":"2006","unstructured":"Dierssen M, Ramakers GJ (2006) Dendritic pathology in mental retardation: from molecular genetics to neurobiology. Genes Brain Behav 5(Suppl 2):48\u201360. https:\/\/doi.org\/10.1111\/j.1601-183X.2006.00224.x","journal-title":"Genes Brain Behav"},{"issue":"2","key":"3953_CR50","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/s0896-6273(00)00133-1","volume":"28","author":"D Fricker","year":"2000","unstructured":"Fricker D, Miles R (2000) EPSP amplification and the precision of spike timing in hippocampal neurons. Neuron 28(2):559\u2013569. https:\/\/doi.org\/10.1016\/s0896-6273(00)00133-1","journal-title":"Neuron"},{"issue":"Pt 3","key":"3953_CR51","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1111\/j.1469-7793.2001.00809.x","volume":"536","author":"B Lancaster","year":"2001","unstructured":"Lancaster B, Hu H, Ramakers GM, Storm JF (2001) Interaction between synaptic excitation and slow afterhyperpolarization current in rat hippocampal pyramidal cells. J Physiol 536(Pt 3):809\u2013823. https:\/\/doi.org\/10.1111\/j.1469-7793.2001.00809.x","journal-title":"J Physiol"},{"issue":"29","key":"3953_CR52","doi-asserted-by":"publisher","first-page":"7696","DOI":"10.1523\/JNEUROSCI.4572-06.2007","volume":"27","author":"T Kirschstein","year":"2007","unstructured":"Kirschstein T, Bauer M, Muller L, Ruschenschmidt C, Reitze M, Becker AJ, Schoch S, Beck H (2007) Loss of metabotropic glutamate receptor-dependent long-term depression via downregulation of mGluR5 after status epilepticus. J Neurosci 27(29):7696\u20137704. https:\/\/doi.org\/10.1523\/JNEUROSCI.4572-06.2007","journal-title":"J Neurosci"},{"issue":"1","key":"3953_CR53","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.neuron.2008.05.014","volume":"59","author":"MW Waung","year":"2008","unstructured":"Waung MW, Pfeiffer BE, Nosyreva ED, Ronesi JA, Huber KM (2008) Rapid translation of Arc\/Arg3.1 selectively mediates mGluR-dependent LTD through persistent increases in AMPAR endocytosis rate. Neuron 59(1):84\u201397. https:\/\/doi.org\/10.1016\/j.neuron.2008.05.014","journal-title":"Neuron"},{"key":"3953_CR54","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-1-4939-7321-7_1","volume":"1677","author":"KB Hansen","year":"2017","unstructured":"Hansen KB, Yi F, Perszyk RE, Menniti FS, Traynelis SF (2017) NMDA receptors in the central nervous system. Methods Mol Biol 1677:1\u201380. https:\/\/doi.org\/10.1007\/978-1-4939-7321-7_1","journal-title":"Methods Mol Biol"},{"issue":"13","key":"3953_CR55","doi-asserted-by":"publisher","first-page":"4590","DOI":"10.1523\/JNEUROSCI.0640-10.2010","volume":"30","author":"JL Brigman","year":"2010","unstructured":"Brigman JL, Wright T, Talani G, Prasad-Mulcare S, Jinde S, Seabold GK, Mathur P, Davis MI, Bock R, Gustin RM, Colbran RJ, Alvarez VA, Nakazawa K, Delpire E, Lovinger DM, Holmes A (2010) Loss of GluN2B-containing NMDA receptors in CA1 hippocampus and cortex impairs long-term depression, reduces dendritic spine density, and disrupts learning. J Neurosci 30(13):4590\u20134600. https:\/\/doi.org\/10.1523\/JNEUROSCI.0640-10.2010","journal-title":"J Neurosci"},{"issue":"4","key":"3953_CR56","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1177\/1073858415588498","volume":"22","author":"SA Connor","year":"2016","unstructured":"Connor SA, Wang YT (2016) A place at the table: LTD as a mediator of memory genesis. Neuroscientist 22(4):359\u2013371. https:\/\/doi.org\/10.1177\/1073858415588498","journal-title":"Neuroscientist"},{"issue":"19","key":"3953_CR57","doi-asserted-by":"publisher","first-page":"4462","DOI":"10.1523\/JNEUROSCI.0394-18.2018","volume":"38","author":"JM Wong","year":"2018","unstructured":"Wong JM, Gray JA (2018) Long-term depression is independent of GluN2 subunit composition. J Neurosci 38(19):4462\u20134470. https:\/\/doi.org\/10.1523\/JNEUROSCI.0394-18.2018","journal-title":"J Neurosci"},{"issue":"3","key":"3953_CR58","first-page":"1285","volume":"283","author":"G Fischer","year":"1997","unstructured":"Fischer G, Mutel V, Trube G, Malherbe P, Kew JN, Mohacsi E, Heitz MP, Kemp JA (1997) Ro 25-6981, a highly potent and selective blocker of N-methyl-d-aspartate receptors containing the NR2B subunit. Characterization in vitro. J Pharmacol Exp Ther 283(3):1285\u20131292","journal-title":"J Pharmacol Exp Ther"},{"issue":"5","key":"3953_CR59","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/s0092-8674(03)00122-3","volume":"112","author":"HK Lee","year":"2003","unstructured":"Lee HK, Takamiya K, Han JS, Man H, Kim CH, Rumbaugh G, Yu S, Ding L, He C, Petralia RS, Wenthold RJ, Gallagher M, Huganir RL (2003) Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory. Cell 112(5):631\u2013643. https:\/\/doi.org\/10.1016\/s0092-8674(03)00122-3","journal-title":"Cell"},{"issue":"5","key":"3953_CR60","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1016\/s0896-6273(00)80632-7","volume":"21","author":"HK Lee","year":"1998","unstructured":"Lee HK, Kameyama K, Huganir RL, Bear MF (1998) NMDA induces long-term synaptic depression and dephosphorylation of the GluR1 subunit of AMPA receptors in hippocampus. Neuron 21(5):1151\u20131162. https:\/\/doi.org\/10.1016\/s0896-6273(00)80632-7","journal-title":"Neuron"},{"issue":"7","key":"3953_CR61","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1038\/nn.2563","volume":"13","author":"MR Brown","year":"2010","unstructured":"Brown MR, Kronengold J, Gazula VR, Chen Y, Strumbos JG, Sigworth FJ, Navaratnam D, Kaczmarek LK (2010) Fragile X mental retardation protein controls gating of the sodium-activated potassium channel Slack. Nat Neurosci 13(7):819\u2013821. https:\/\/doi.org\/10.1038\/nn.2563","journal-title":"Nat Neurosci"},{"issue":"5","key":"3953_CR62","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1177\/1073858409333075","volume":"15","author":"BE Pfeiffer","year":"2009","unstructured":"Pfeiffer BE, Huber KM (2009) The state of synapses in fragile X syndrome. Neuroscientist 15(5):549\u2013567. https:\/\/doi.org\/10.1177\/1073858409333075","journal-title":"Neuroscientist"},{"key":"3953_CR63","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/1756-6606-6-15","volume":"6","author":"MS Sidorov","year":"2013","unstructured":"Sidorov MS, Auerbach BD, Bear MF (2013) Fragile X mental retardation protein and synaptic plasticity. Mol Brain 6:15. https:\/\/doi.org\/10.1186\/1756-6606-6-15","journal-title":"Mol Brain"},{"issue":"11","key":"3953_CR64","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/j.tins.2011.08.007","volume":"34","author":"E Korb","year":"2011","unstructured":"Korb E, Finkbeiner S (2011) Arc in synaptic plasticity: from gene to behavior. Trends Neurosci 34(11):591\u2013598. https:\/\/doi.org\/10.1016\/j.tins.2011.08.007","journal-title":"Trends Neurosci"},{"issue":"6480","key":"3953_CR65","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1038\/369486a0","volume":"369","author":"RM Mulkey","year":"1994","unstructured":"Mulkey RM, Endo S, Shenolikar S, Malenka RC (1994) Involvement of a calcineurin\/inhibitor-1 phosphatase cascade in hippocampal long-term depression. Nature 369(6480):486\u2013488. https:\/\/doi.org\/10.1038\/369486a0","journal-title":"Nature"},{"issue":"38","key":"3953_CR66","doi-asserted-by":"publisher","first-page":"13200","DOI":"10.1523\/JNEUROSCI.0061-12.2012","volume":"32","author":"M Fernandez-Monreal","year":"2012","unstructured":"Fernandez-Monreal M, Brown TC, Royo M, Esteban JA (2012) The balance between receptor recycling and trafficking toward lysosomes determines synaptic strength during long-term depression. J Neurosci 32(38):13200\u201313205. https:\/\/doi.org\/10.1523\/JNEUROSCI.0061-12.2012","journal-title":"J Neurosci"},{"issue":"25","key":"3953_CR67","doi-asserted-by":"publisher","first-page":"15635","DOI":"10.1074\/jbc.M114.628776","volume":"290","author":"AM Lenselink","year":"2015","unstructured":"Lenselink AM, Rotaru DC, Li KW, van Nierop P, Rao-Ruiz P, Loos M, van der Schors R, Gouwenberg Y, Wortel J, Mansvelder HD, Smit AB, Spijker S (2015) Strain differences in presynaptic function: proteomics, ultrastructure, and physiology of hippocampal synapses in DBA\/2J and C57Bl\/6J mice. J Biol Chem 290(25):15635\u201315645. https:\/\/doi.org\/10.1074\/jbc.M114.628776","journal-title":"J Biol Chem"},{"issue":"4","key":"3953_CR68","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1016\/j.mcn.2010.07.011","volume":"45","author":"MD Antion","year":"2010","unstructured":"Antion MD, Christie LA, Bond AM, Dalva MB, Contractor A (2010) Ephrin-B3 regulates glutamate receptor signaling at hippocampal synapses. Mol Cell Neurosci 45(4):378\u2013388. https:\/\/doi.org\/10.1016\/j.mcn.2010.07.011","journal-title":"Mol Cell Neurosci"},{"issue":"34","key":"3953_CR69","doi-asserted-by":"publisher","first-page":"14300","DOI":"10.1073\/pnas.1112237108","volume":"108","author":"T Tsetsenis","year":"2011","unstructured":"Tsetsenis T, Younts TJ, Chiu CQ, Kaeser PS, Castillo PE, Sudhof TC (2011) Rab3B protein is required for long-term depression of hippocampal inhibitory synapses and for normal reversal learning. Proc Natl Acad Sci USA 108(34):14300\u201314305. https:\/\/doi.org\/10.1073\/pnas.1112237108","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"3953_CR70","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1080\/21541248.2017.1337546","volume":"10","author":"A Hausser","year":"2019","unstructured":"Hausser A, Schlett K (2019) Coordination of AMPA receptor trafficking by Rab GTPases. Small GTPases 10(6):419\u2013432. https:\/\/doi.org\/10.1080\/21541248.2017.1337546","journal-title":"Small GTPases"},{"issue":"16","key":"3953_CR71","doi-asserted-by":"publisher","first-page":"3935","DOI":"10.1113\/jphysiol.2013.255075","volume":"591","author":"J Cheng","year":"2013","unstructured":"Cheng J, Liu W, Duffney LJ, Yan Z (2013) SNARE proteins are essential in the potentiation of NMDA receptors by group II metabotropic glutamate receptors. J Physiol 591(16):3935\u20133947. https:\/\/doi.org\/10.1113\/jphysiol.2013.255075","journal-title":"J Physiol"},{"issue":"2","key":"3953_CR72","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1111\/j.1460-9568.2006.05287.x","volume":"25","author":"E Nanou","year":"2007","unstructured":"Nanou E, El Manira A (2007) A postsynaptic negative feedback mediated by coupling between AMPA receptors and Na+-activated K+ channels in spinal cord neurones. Eur J Neurosci 25(2):445\u2013450. https:\/\/doi.org\/10.1111\/j.1460-9568.2006.05287.x","journal-title":"Eur J Neurosci"},{"issue":"4","key":"3953_CR73","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1002\/ana.24128","volume":"75","author":"CJ Milligan","year":"2014","unstructured":"Milligan CJ, Li M, Gazina EV, Heron SE, Nair U, Trager C, Reid CA, Venkat A, Younkin DP, Dlugos DJ, Petrovski S, Goldstein DB, Dibbens LM, Scheffer IE, Berkovic SF, Petrou S (2014) KCNT1 gain of function in 2 epilepsy phenotypes is reversed by quinidine. Ann Neurol 75(4):581\u2013590. https:\/\/doi.org\/10.1002\/ana.24128","journal-title":"Ann Neurol"},{"key":"3953_CR74","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.coph.2014.11.008","volume":"20","author":"N Burnashev","year":"2015","unstructured":"Burnashev N, Szepetowski P (2015) NMDA receptor subunit mutations in neurodevelopmental disorders. Curr Opin Pharmacol 20:73\u201382. https:\/\/doi.org\/10.1016\/j.coph.2014.11.008","journal-title":"Curr Opin Pharmacol"},{"key":"3953_CR75","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-020-00859-4","author":"CA Mielnik","year":"2020","unstructured":"Mielnik CA, Binko MA, Chen Y, Funk AJ, Johansson EM, Intson K, Sivananthan N, Islam R, Milenkovic M, Horsfall W, Ross RA, Groc L, Salahpour A, McCullumsmith RE, Tripathy S, Lambe EK, Ramsey AJ (2020) Consequences of NMDA receptor deficiency can be rescued in the adult brain. Mol Psychiatry. https:\/\/doi.org\/10.1038\/s41380-020-00859-4","journal-title":"Mol Psychiatry"},{"issue":"52","key":"3953_CR76","doi-asserted-by":"publisher","first-page":"20941","DOI":"10.1073\/pnas.0806403106","volume":"105","author":"E Nanou","year":"2008","unstructured":"Nanou E, Kyriakatos A, Bhattacharjee A, Kaczmarek LK, Paratcha G, El Manira A (2008) Na+-mediated coupling between AMPA receptors and KNa channels shapes synaptic transmission. Proc Natl Acad Sci USA 105(52):20941\u201320946. https:\/\/doi.org\/10.1073\/pnas.0806403106","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5","key":"3953_CR77","doi-asserted-by":"publisher","first-page":"e21568","DOI":"10.1096\/fj.202002308RR","volume":"35","author":"R Ehinger","year":"2021","unstructured":"Ehinger R, Kuret A, Matt L, Frank N, Wild K, Kabagema-Bilan C, Bischof H, Malli R, Ruth P, Bausch AE, Lukowski R (2021) Slack K(+) channels attenuate NMDA-induced excitotoxic brain damage and neuronal cell death. FASEB J 35(5):e21568. https:\/\/doi.org\/10.1096\/fj.202002308RR","journal-title":"FASEB J"},{"issue":"4","key":"3953_CR78","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1016\/j.bbrc.2003.09.133","volume":"310","author":"S Uchino","year":"2003","unstructured":"Uchino S, Wada H, Honda S, Hirasawa T, Yanai S, Nakamura Y, Ondo Y, Kohsaka S (2003) Slo2 sodium-activated K+ channels bind to the PDZ domain of PSD-95. Biochem Biophys Res Commun 310(4):1140\u20131147. https:\/\/doi.org\/10.1016\/j.bbrc.2003.09.133","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"3953_CR79","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1177\/1073858408315041","volume":"14","author":"J Kim","year":"2008","unstructured":"Kim J, Hoffman DA (2008) Potassium channels: newly found players in synaptic plasticity. Neuroscientist 14(3):276\u2013286. https:\/\/doi.org\/10.1177\/1073858408315041","journal-title":"Neuroscientist"},{"issue":"25","key":"3953_CR80","doi-asserted-by":"publisher","first-page":"9474","DOI":"10.1073\/pnas.0401702101","volume":"101","author":"M Sausbier","year":"2004","unstructured":"Sausbier M, Hu H, Arntz C, Feil S, Kamm S, Adelsberger H, Sausbier U, Sailer CA, Feil R, Hofmann F, Korth M, Shipston MJ, Knaus HG, Wolfer DP, Pedroarena CM, Storm JF, Ruth P (2004) Cerebellar ataxia and Purkinje cell dysfunction caused by Ca2+-activated K+ channel deficiency. Proc Natl Acad Sci USA 101(25):9474\u20139478. https:\/\/doi.org\/10.1073\/pnas.0401702101","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"3953_CR81","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/nn985","volume":"6","author":"H Yasuda","year":"2003","unstructured":"Yasuda H, Barth AL, Stellwagen D, Malenka RC (2003) A developmental switch in the signaling cascades for LTP induction. Nat Neurosci 6(1):15\u201316. https:\/\/doi.org\/10.1038\/nn985","journal-title":"Nat Neurosci"},{"issue":"11","key":"3953_CR82","doi-asserted-by":"publisher","first-page":"2992","DOI":"10.1523\/JNEUROSCI.3652-04.2005","volume":"25","author":"ED Nosyreva","year":"2005","unstructured":"Nosyreva ED, Huber KM (2005) Developmental switch in synaptic mechanisms of hippocampal metabotropic glutamate receptor-dependent long-term depression. J Neurosci 25(11):2992\u20133001. https:\/\/doi.org\/10.1523\/JNEUROSCI.3652-04.2005","journal-title":"J Neurosci"}],"container-title":["Cellular and Molecular Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-021-03953-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00018-021-03953-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-021-03953-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T07:09:35Z","timestamp":1638169775000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00018-021-03953-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,18]]},"references-count":82,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["3953"],"URL":"https:\/\/doi.org\/10.1007\/s00018-021-03953-0","relation":{},"ISSN":["1420-682X","1420-9071"],"issn-type":[{"value":"1420-682X","type":"print"},{"value":"1420-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,18]]},"assertion":[{"value":"20 January 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 September 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 October 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All experimental procedures were conducted in accordance with the animal protection laws in Germany and were approved by the local Ethics Committee for Animal Research (Regierungspr\u00e4sidium T\u00fcbingen).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}