{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T02:04:02Z","timestamp":1774922642047,"version":"3.50.1"},"reference-count":215,"publisher":"Springer Science and Business Media LLC","issue":"24","license":[{"start":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T00:00:00Z","timestamp":1637020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T00:00:00Z","timestamp":1637020800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the National Key R&D Program of China","award":["2017YFA0104900"],"award-info":[{"award-number":["2017YFA0104900"]}]},{"name":"the Natural Sciences Foundation of China","award":["81630065"],"award-info":[{"award-number":["81630065"]}]},{"name":"the Natural Sciences Foundation of China","award":["82002319"],"award-info":[{"award-number":["82002319"]}]},{"DOI":"10.13039\/501100002858","name":"the China Postdoctoral Science Foundation","doi-asserted-by":"crossref","award":["2020M681892"],"award-info":[{"award-number":["2020M681892"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell. Mol. Life Sci."],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1007\/s00018-021-03983-8","type":"journal-article","created":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T06:04:17Z","timestamp":1637042657000},"page":"8127-8155","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Pharmaceutical therapeutics for articular regeneration and restoration: state-of-the-art technology for screening small molecular drugs"],"prefix":"10.1007","volume":"78","author":[{"given":"Yishan","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xudong","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeke","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiyang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujie","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0627-2536","authenticated-orcid":false,"given":"Hongwei","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,11,16]]},"reference":[{"issue":"3","key":"3983_CR1","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/j.csm.2017.02.008","volume":"36","author":"BB Hinckel","year":"2017","unstructured":"Hinckel BB, Gomoll AH (2017) Autologous chondrocytes and next-generation matrix-based autologous chondrocyte implantation. Clin Sports Med 36(3):525\u2013548","journal-title":"Clin Sports Med"},{"issue":"11","key":"3983_CR2","doi-asserted-by":"publisher","first-page":"8423","DOI":"10.1136\/bmjopen-2015-008423","volume":"5","author":"CN Engen","year":"2015","unstructured":"Engen CN, \u00c5r\u00f8en A, Engebretsen L (2015) Incidence of knee cartilage surgery in Norway, 2008\u20132011. BMJ Open 5(11):8423","journal-title":"BMJ Open"},{"issue":"10182","key":"3983_CR3","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1016\/S0140-6736(19)30417-9","volume":"393","author":"DJ Hunter","year":"2019","unstructured":"Hunter DJ, Bierma-Zeinstra S (2019) Osteoarthritis. Lancet 393(10182):1745\u20131759","journal-title":"Lancet"},{"issue":"8","key":"3983_CR4","doi-asserted-by":"publisher","first-page":"2366","DOI":"10.3390\/ijms19082366","volume":"19","author":"EV Medvedeva","year":"2018","unstructured":"Medvedeva EV, Grebenik EA, Gornostaeva SN et al (2018) Repair of damaged articular cartilage: current approaches and future directions. Int J Mol Sci 19(8):2366","journal-title":"Int J Mol Sci"},{"issue":"8","key":"3983_CR5","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1007\/s13238-017-0377-7","volume":"8","author":"Y Luo","year":"2017","unstructured":"Luo Y, Sinkeviciute D, He Y et al (2017) The minor collagens in articular cartilage. Protein Cell 8(8):560\u2013572","journal-title":"Protein Cell"},{"issue":"3","key":"3983_CR6","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.joca.2014.11.004","volume":"23","author":"KL Caldwell","year":"2015","unstructured":"Caldwell KL, Wang J (2015) Cell-based articular cartilage repair: the link between development and regeneration. Osteoarthr Cartil 23(3):351\u2013362","journal-title":"Osteoarthr Cartil"},{"key":"3983_CR7","doi-asserted-by":"crossref","unstructured":"Chhabra M (2021) Biological therapeutic modalities. Transl Biotechnol","DOI":"10.1016\/B978-0-12-821972-0.00015-0"},{"issue":"6146","key":"3983_CR8","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1126\/science.1239278","volume":"341","author":"P Hou","year":"2013","unstructured":"Hou P, Li Y, Zhang X et al (2013) Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science 341(6146):651\u2013654","journal-title":"Science"},{"issue":"6","key":"3983_CR9","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1038\/cr.2014.32","volume":"24","author":"L Cheng","year":"2014","unstructured":"Cheng L, Hu W, Qiu B et al (2014) Generation of neural progenitor cells by chemical cocktails and hypoxia. Cell Res 24(6):665\u2013679","journal-title":"Cell Res"},{"issue":"3","key":"3983_CR10","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/j.stem.2016.02.001","volume":"18","author":"Y Zhang","year":"2016","unstructured":"Zhang Y, Cao N, Huang Y et al (2016) Expandable cardiovascular progenitor cells reprogrammed from fibroblasts. Cell Stem Cell 18(3):368\u2013381","journal-title":"Cell Stem Cell"},{"issue":"11","key":"3983_CR11","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1038\/nrd.2016.139","volume":"15","author":"JM Ostrem","year":"2016","unstructured":"Ostrem JM, Shokat KM (2016) Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based design. Nat Rev Drug Discov 15(11):771\u2013785","journal-title":"Nat Rev Drug Discov"},{"issue":"10","key":"3983_CR12","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/nrd4592","volume":"14","author":"CB Nanthakumar","year":"2015","unstructured":"Nanthakumar CB, Hatley RJ, Lemma S, Gauldie J, Marshall RP, Macdonald SJ (2015) Dissecting fibrosis: therapeutic insights from the small-molecule toolbox. Nat Rev Drug Discov 14(10):693\u2013720","journal-title":"Nat Rev Drug Discov"},{"issue":"3","key":"3983_CR13","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1080\/14656566.2017.1284794","volume":"18","author":"NC Thomson","year":"2017","unstructured":"Thomson NC (2017) New and developing non-adrenoreceptor small molecule drugs for the treatment of asthma. Expert Opin Pharmacother 18(3):283\u2013293","journal-title":"Expert Opin Pharmacother"},{"issue":"1","key":"3983_CR14","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.stem.2018.05.025","volume":"23","author":"T Zhao","year":"2018","unstructured":"Zhao T, Fu Y, Zhu J et al (2018) Single-cell RNA-Seq reveals dynamic early embryonic-like programs during chemical reprogramming. Cell Stem Cell 23(1):31-45.e7","journal-title":"Cell Stem Cell"},{"issue":"3","key":"3983_CR15","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.stem.2013.08.002","volume":"13","author":"W Li","year":"2013","unstructured":"Li W, Li K, Wei W, Ding S (2013) Chemical approaches to stem cell biology and therapeutics. Cell Stem Cell 13(3):270\u2013283","journal-title":"Cell Stem Cell"},{"issue":"8","key":"3983_CR16","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1038\/nrd.2016.29","volume":"15","author":"DE Scott","year":"2016","unstructured":"Scott DE, Bayly AR, Abell C, Skidmore J (2016) Small molecules, big targets: drug discovery faces the protein-protein interaction challenge. Nat Rev Drug Discov 15(8):533\u2013550","journal-title":"Nat Rev Drug Discov"},{"issue":"22","key":"3983_CR17","doi-asserted-by":"publisher","first-page":"1662","DOI":"10.1089\/scd.2017.0104","volume":"26","author":"V Bunpetch","year":"2017","unstructured":"Bunpetch V, Wu H, Zhang S, Ouyang H (2017) From, \u201cBench to Bedside\u201d: current advancement on large-scale production of mesenchymal stem cells. Stem Cells Dev 26(22):1662\u20131673","journal-title":"Stem Cells Dev"},{"issue":"4","key":"3983_CR18","doi-asserted-by":"crossref","first-page":"475","DOI":"10.2217\/rme.12.41","volume":"7","author":"A Hayek","year":"2012","unstructured":"Hayek A, Kerstetter-Fogle AE, Sachlos E, Bollenbach T (2012) Kartogenin: a game-changer in regenerative medicine. Regen Med 7(4):475","journal-title":"Regen Med"},{"issue":"6082","key":"3983_CR19","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1126\/science.1215157","volume":"336","author":"K Johnson","year":"2012","unstructured":"Johnson K, Zhu S, Tremblay MS et al (2012) A stem cell-based approach to cartilage repair. Science 336(6082):717\u2013721","journal-title":"Science"},{"issue":"1","key":"3983_CR20","doi-asserted-by":"publisher","first-page":"1710","DOI":"10.1080\/21691401.2019.1607866","volume":"47","author":"J Wang","year":"2019","unstructured":"Wang J, Wang Y, Sun X et al (2019) Biomimetic cartilage scaffold with orientated porous structure of two factors for cartilage repair of knee osteoarthritis. Artif Cells Nanomed Biotechnol 47(1):1710\u20131721","journal-title":"Artif Cells Nanomed Biotechnol"},{"key":"3983_CR21","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.actbio.2016.05.005","volume":"39","author":"ML Kang","year":"2016","unstructured":"Kang ML, Kim JE, Im GI (2016) Thermoresponsive nanospheres with independent dual drug release profiles for the treatment of osteoarthritis. Acta Biomater 39:65\u201378","journal-title":"Acta Biomater"},{"issue":"13\u201314","key":"3983_CR22","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1089\/ten.tea.2016.0524","volume":"23","author":"ML Kang","year":"2017","unstructured":"Kang ML, Jeong SY, Im GI (2017) Hyaluronic acid hydrogel functionalized with self-assembled micelles of amphiphilic PEGylated kartogenin for the treatment of osteoarthritis. Tissue Eng Part A 23(13\u201314):630\u2013639","journal-title":"Tissue Eng Part A"},{"issue":"1","key":"3983_CR23","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1080\/10717544.2018.1461279","volume":"25","author":"W Fan","year":"2018","unstructured":"Fan W, Li J, Yuan L et al (2018) Intra-articular injection of kartogenin-conjugated polyurethane nanoparticles attenuates the progression of osteoarthritis. Drug Deliv 25(1):1004\u20131012","journal-title":"Drug Deliv"},{"issue":"5","key":"3983_CR24","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1136\/annrheumdis-2012-201745","volume":"72","author":"F Yano","year":"2013","unstructured":"Yano F, Hojo H, Ohba S et al (2013) A novel disease-modifying osteoarthritis drug candidate targeting Runx1. Ann Rheum Dis 72(5):748\u2013753","journal-title":"Ann Rheum Dis"},{"issue":"11","key":"3983_CR25","doi-asserted-by":"publisher","first-page":"2062","DOI":"10.1136\/annrheumdis-2014-205672","volume":"73","author":"F Yano","year":"2014","unstructured":"Yano F, Ohba S, Hosaka Y, Saito T, Chung UI (2014) Disease-modifying effects of TD-198946 on progressed osteoarthritis in a mouse model. Ann Rheum Dis 73(11):2062\u20132064","journal-title":"Ann Rheum Dis"},{"issue":"3","key":"3983_CR26","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1002\/term.2795","volume":"13","author":"R Chijimatsu","year":"2019","unstructured":"Chijimatsu R, Yano F, Saito T et al (2019) Effect of the small compound TD-198946 on glycosaminoglycan synthesis and transforming growth factor \u03b23-associated chondrogenesis of human synovium-derived stem cells in vitro. J Tissue Eng Regen Med 13(3):446\u2013458","journal-title":"J Tissue Eng Regen Med"},{"issue":"21","key":"3983_CR27","doi-asserted-by":"publisher","first-page":"7467","DOI":"10.1073\/pnas.0802825105","volume":"105","author":"KC Hwang","year":"2008","unstructured":"Hwang KC, Kim JY, Chang W et al (2008) Chemicals that modulate stem cell differentiation. Proc Natl Acad Sci USA 105(21):7467\u20137471","journal-title":"Proc Natl Acad Sci USA"},{"issue":"20","key":"3983_CR28","doi-asserted-by":"publisher","first-page":"5098","DOI":"10.1016\/j.bmcl.2016.08.069","volume":"26","author":"E Choi","year":"2016","unstructured":"Choi E, Lee J, Lee S et al (2016) Potential therapeutic application of small molecule with sulfonamide for chondrogenic differentiation and articular cartilage repair. Bioorg Med Chem Lett 26(20):5098\u20135102","journal-title":"Bioorg Med Chem Lett"},{"issue":"8","key":"3983_CR29","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1177\/0963689717720278","volume":"26","author":"BE Heck","year":"2017","unstructured":"Heck BE, Park JJ, Makani V, Kim EC, Kim DH (2017) PPAR-\u03b4 agonist with mesenchymal stem cells induces type II collagen-producing chondrocytes in human arthritic synovial fluid. Cell Transplant 26(8):1405\u20131417","journal-title":"Cell Transplant"},{"issue":"32","key":"3983_CR30","doi-asserted-by":"publisher","first-page":"22048","DOI":"10.1074\/jbc.M114.568790","volume":"289","author":"C Buhrmann","year":"2014","unstructured":"Buhrmann C, Busch F, Shayan P, Shakibaei M (2014) Sirtuin-1 (SIRT1) is required for promoting chondrogenic differentiation of mesenchymal stem cells. J Biol Chem 289(32):22048\u201322062","journal-title":"J Biol Chem"},{"issue":"1","key":"3983_CR31","doi-asserted-by":"publisher","first-page":"88","DOI":"10.15171\/apb.2020.011","volume":"10","author":"G Keshavarz","year":"2020","unstructured":"Keshavarz G, Jalili C, Pazhouhi M, Khazaei M (2020) Resveratrol effect on adipose-derived stem cells differentiation to chondrocyte in three-dimensional culture. Adv Pharm Bull 10(1):88\u201396","journal-title":"Adv Pharm Bull"},{"issue":"2","key":"3983_CR32","first-page":"107","volume":"39","author":"M Baghaban Eslaminejad","year":"2014","unstructured":"Baghaban Eslaminejad M, Fallah N (2014) Small molecule-BIO accelerates and enhances marrow-derived mesenchymal stem cell in vitro chondrogenesis. Iran J Med Sci 39(2):107\u2013116","journal-title":"Iran J Med Sci"},{"issue":"6","key":"3983_CR33","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1007\/s00774-010-0179-y","volume":"28","author":"H Hojo","year":"2010","unstructured":"Hojo H, Yano F, Ohba S et al (2010) Identification of oxytetracycline as a chondrogenic compound using a cell-based screening system. J Bone Miner Metab 28(6):627\u2013633","journal-title":"J Bone Miner Metab"},{"issue":"7","key":"3983_CR34","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1089\/ten.tec.2014.0088","volume":"21","author":"BQ Le","year":"2015","unstructured":"Le BQ, Fernandes H, Bouten CV, Karperien M, van Blitterswijk C, de Boer J (2015) High-throughput screening assay for the identification of compounds enhancing collagenous extracellular matrix production by ATDC5 Cells. Tissue Eng Part C Methods 21(7):726\u2013736","journal-title":"Tissue Eng Part C Methods"},{"issue":"7","key":"3983_CR35","doi-asserted-by":"publisher","first-page":"1708","DOI":"10.1002\/jcp.25486","volume":"232","author":"L Duan","year":"2017","unstructured":"Duan L, Liang Y, Ma B et al (2017) DNA methylation profiling in chondrocyte dedifferentiation in vitro. J Cell Physiol 232(7):1708\u20131716","journal-title":"J Cell Physiol"},{"issue":"1","key":"3983_CR36","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.1016\/j.bbrc.2017.11.180","volume":"495","author":"T Kobayashi","year":"2018","unstructured":"Kobayashi T, Fujita K, Kamatani T, Matsuda S, Tsumaki N (2018) A-674563 increases chondrocyte marker expression in cultured chondrocytes by inhibiting Sox9 degradation. Biochem Biophys Res Commun 495(1):1468\u20131475","journal-title":"Biochem Biophys Res Commun"},{"key":"3983_CR37","doi-asserted-by":"publisher","first-page":"1092015","DOI":"10.1155\/2017\/1092015","volume":"2017","author":"NM Al-Rasheed","year":"2017","unstructured":"Al-Rasheed NM, Al-Rasheed NM, Hasan IH et al (2017) Simvastatin ameliorates diabetic cardiomyopathy by attenuating oxidative stress and inflammation in rats. Oxid Med Cell Longev 2017:1092015","journal-title":"Oxid Med Cell Longev"},{"key":"3983_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.abb.2019.01.038","volume":"665","author":"K Terabe","year":"2019","unstructured":"Terabe K, Takahashi N, Cobb M, Askew EB, Knudson CB, Knudson W (2019) Simvastatin promotes restoration of chondrocyte morphology and phenotype. Arch Biochem Biophys 665:1\u201311","journal-title":"Arch Biochem Biophys"},{"issue":"1","key":"3983_CR39","first-page":"33","volume":"13","author":"A Nardi","year":"2016","unstructured":"Nardi A, Ventura L, Cozzi L, Tonini G (2016) Clodronate news of efficacy in osteoporosis. Clin Cases Miner Bone Metab 13(1):33\u201335","journal-title":"Clin Cases Miner Bone Metab"},{"issue":"9","key":"3983_CR40","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1016\/j.joca.2014.07.009","volume":"22","author":"RG Rosa","year":"2014","unstructured":"Rosa RG, Collavino K, Lakhani A et al (2014) Clodronate exerts an anabolic effect on articular chondrocytes mediated through the purinergic receptor pathway. Osteoarthr Cartil 22(9):1327\u20131336","journal-title":"Osteoarthr Cartil"},{"key":"3983_CR41","doi-asserted-by":"crossref","unstructured":"Valenti MT, Mottes M, Biotti A, et al (2017) Clodronate as a therapeutic strategy against osteoarthritis. Int J Mol Sci 18(12)","DOI":"10.3390\/ijms18122696"},{"issue":"2","key":"3983_CR42","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1002\/art.23302","volume":"58","author":"K Pelttari","year":"2008","unstructured":"Pelttari K, Lorenz H, Boeuf S et al (2008) Secretion of matrix metalloproteinase 3 by expanded articular chondrocytes as a predictor of ectopic cartilage formation capacity in vivo. Arthritis Rheum 58(2):467\u2013474","journal-title":"Arthritis Rheum"},{"issue":"Suppl 4","key":"3983_CR43","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1136\/ard.2005.042465","volume":"64","author":"G Murphy","year":"2005","unstructured":"Murphy G, Lee MH (2005) What are the roles of metalloproteinases in cartilage and bone damage. Ann Rheum Dis 64(Suppl 4):44\u201347","journal-title":"Ann Rheum Dis"},{"issue":"6","key":"3983_CR44","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1089\/ten.2006.0342","volume":"13","author":"SE Francioli","year":"2007","unstructured":"Francioli SE, Martin I, Sie CP et al (2007) Growth factors for clinical-scale expansion of human articular chondrocytes: relevance for automated bioreactor systems. Tissue Eng 13(6):1227\u20131234","journal-title":"Tissue Eng"},{"issue":"3","key":"3983_CR45","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.stemcr.2015.01.016","volume":"4","author":"A Yamashita","year":"2015","unstructured":"Yamashita A, Morioka M, Yahara Y et al (2015) Generation of scaffoldless hyaline cartilaginous tissue from human iPSCs. Stem Cell Rep 4(3):404\u2013418","journal-title":"Stem Cell Rep"},{"issue":"4","key":"3983_CR46","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","volume":"126","author":"K Takahashi","year":"2006","unstructured":"Takahashi K, Yamanaka S (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126(4):663\u2013676","journal-title":"Cell"},{"issue":"6","key":"3983_CR47","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1016\/j.stemcr.2018.11.012","volume":"11","author":"S Chen","year":"2018","unstructured":"Chen S (2018) Screening-based chemical approaches to unravel stem cell biology. Stem Cell Rep 11(6):1312\u20131323","journal-title":"Stem Cell Rep"},{"issue":"7","key":"3983_CR48","doi-asserted-by":"publisher","first-page":"1570","DOI":"10.1016\/j.cell.2015.12.011","volume":"163","author":"H Niwa","year":"2015","unstructured":"Niwa H (2015) A stepping stone to pluripotency. Cell 163(7):1570\u20131572","journal-title":"Cell"},{"issue":"7","key":"3983_CR49","doi-asserted-by":"publisher","first-page":"1678","DOI":"10.1016\/j.cell.2015.11.017","volume":"163","author":"Y Zhao","year":"2015","unstructured":"Zhao Y, Zhao T, Guan J et al (2015) A XEN-like State bridges somatic cells to pluripotency during chemical reprogramming. Cell 163(7):1678\u20131691","journal-title":"Cell"},{"issue":"3","key":"3983_CR50","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1016\/j.stemcr.2020.01.013","volume":"14","author":"Y Chen","year":"2020","unstructured":"Chen Y, Wu B, Lin J et al (2020) High-resolution dissection of chemical reprogramming from mouse embryonic fibroblasts into fibrocartilaginous cells. Stem Cell Reports 14(3):478\u2013492","journal-title":"Stem Cell Reports"},{"issue":"3","key":"3983_CR51","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.chembiol.2021.02.001","volume":"28","author":"JJ Vandana","year":"2021","unstructured":"Vandana JJ, Lacko LA, Chen S (2021) Phenotypic technologies in stem cell biology. Cell Chem Biol 28(3):257\u2013270","journal-title":"Cell Chem Biol"},{"issue":"26","key":"3983_CR52","doi-asserted-by":"publisher","first-page":"2522","DOI":"10.1056\/NEJMcibr1204283","volume":"366","author":"JC Marini","year":"2012","unstructured":"Marini JC, Forlino A (2012) Replenishing cartilage from endogenous stem cells. N Engl J Med 366(26):2522\u20132524","journal-title":"N Engl J Med"},{"issue":"Pt 1","key":"3983_CR53","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.semcancer.2020.04.008","volume":"67","author":"H Song","year":"2020","unstructured":"Song H, Park KH (2020) Regulation and function of SOX9 during cartilage development and regeneration. Semin Cancer Biol 67(Pt 1):12\u201323","journal-title":"Semin Cancer Biol"},{"issue":"1","key":"3983_CR54","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1007\/s00441-005-0050-y","volume":"323","author":"C Hidaka","year":"2006","unstructured":"Hidaka C, Cheng C, Alexandre D, Bhargava M, Torzilli PA (2006) Maturational differences in superficial and deep zone articular chondrocytes. Cell Tissue Res 323(1):127\u2013135","journal-title":"Cell Tissue Res"},{"issue":"2","key":"3983_CR55","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.celrep.2019.06.031","volume":"28","author":"SL Wolock","year":"2019","unstructured":"Wolock SL, Krishnan I, Tenen DE et al (2019) Mapping distinct bone marrow niche populations and their differentiation paths. Cell Rep 28(2):302-311.e5","journal-title":"Cell Rep"},{"issue":"8","key":"3983_CR56","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1002\/jbmr.3719","volume":"34","author":"K Mizuhashi","year":"2019","unstructured":"Mizuhashi K, Nagata M, Matsushita Y, Ono W, Ono N (2019) Growth plate borderline chondrocytes behave as transient mesenchymal precursor cells. J Bone Miner Res 34(8):1387\u20131392","journal-title":"J Bone Miner Res"},{"issue":"7","key":"3983_CR57","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1038\/s41422-021-00467-z","volume":"31","author":"J He","year":"2021","unstructured":"He J, Yan J, Wang J et al (2021) Dissecting human embryonic skeletal stem cell ontogeny by single-cell transcriptomic and functional analyses. Cell Res 31(7):742\u2013757","journal-title":"Cell Res"},{"key":"3983_CR58","doi-asserted-by":"crossref","unstructured":"Rakic R, Bourdon B, Hervieu M et al (2017) RNA Interference and BMP-2 stimulation allows equine chondrocytes redifferentiation in 3D-hypoxia cell culture model: application for matrix-induced autologous chondrocyte implantation. Int J Mol Sci 18(9)","DOI":"10.3390\/ijms18091842"},{"issue":"4","key":"3983_CR59","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1080\/14728214.2018.1547706","volume":"23","author":"WM Oo","year":"2018","unstructured":"Oo WM, Yu SP, Daniel MS, Hunter DJ (2018) Disease-modifying drugs in osteoarthritis: current understanding and future therapeutics. Expert Opin Emerg Drugs 23(4):331\u2013347","journal-title":"Expert Opin Emerg Drugs"},{"issue":"1","key":"3983_CR60","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/nrrheum.2010.196","volume":"7","author":"M Kapoor","year":"2011","unstructured":"Kapoor M, Martel-Pelletier J, Lajeunesse D, Pelletier JP, Fahmi H (2011) Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Nat Rev Rheumatol 7(1):33\u201342","journal-title":"Nat Rev Rheumatol"},{"issue":"6","key":"3983_CR61","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1002\/jor.20180","volume":"24","author":"HK Kitadai","year":"2006","unstructured":"Kitadai HK, Takahashi HK, Straus AH et al (2006) Effect of oral diacerein (DAR) in an experimental hip chondrolysis model. J Orthop Res 24(6):1240\u20131248","journal-title":"J Orthop Res"},{"issue":"5","key":"3983_CR62","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1590\/S1807-59322006000500014","volume":"61","author":"MU Rezende","year":"2006","unstructured":"Rezende MU, Gurgel HM, Vila\u00e7a Junior PR et al (2006) Diacerhein versus glucosamine in a rat model of osteoarthritis. Clinics (Sao Paulo) 61(5):461\u2013466","journal-title":"Clinics (Sao Paulo)"},{"issue":"2","key":"3983_CR63","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/s40266-016-0347-4","volume":"33","author":"K Pavelka","year":"2016","unstructured":"Pavelka K, Bruy\u00e8re O, Cooper C et al (2016) Diacerein: benefits, risks and place in the management of osteoarthritis an opinion-based report from the ESCEO. Drugs Aging 33(2):75\u201385","journal-title":"Drugs Aging"},{"issue":"17 Suppl","key":"3983_CR64","first-page":"S24","volume":"48","author":"P Ghosh","year":"1998","unstructured":"Ghosh P, Xu A, Hwa SY, Burkhardt D, Little C (1998) Evaluation of the effects of diacerhein in the sheep model of arthritis. Rev Prat 48(17 Suppl):S24-30","journal-title":"Rev Prat"},{"key":"3983_CR65","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.3389\/fphar.2018.01378","volume":"9","author":"S Liang","year":"2018","unstructured":"Liang S, Lv ZT, Zhang JM et al (2018) Necrostatin-1 attenuates trauma-induced mouse osteoarthritis and IL-1\u03b2 induced apoptosis via HMGB1\/TLR4\/SDF-1 in primary mouse chondrocytes. Front Pharmacol 9:1378","journal-title":"Front Pharmacol"},{"issue":"6","key":"3983_CR66","doi-asserted-by":"publisher","first-page":"a001651","DOI":"10.1101\/cshperspect.a001651","volume":"1","author":"T Lawrence","year":"2009","unstructured":"Lawrence T (2009) The nuclear factor NF-kappaB pathway in inflammation. Cold Spring Harb Perspect Biol 1(6):a001651","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"5","key":"3983_CR67","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1302\/2046-3758.45.2000378","volume":"4","author":"K Hamamura","year":"2015","unstructured":"Hamamura K, Nishimura A, Iino T, Takigawa S, Sudo A, Yokota H (2015) Chondroprotective effects of Salubrinal in a mouse model of osteoarthritis. Bone Jt Res 4(5):84\u201392","journal-title":"Bone Jt Res"},{"issue":"1","key":"3983_CR68","doi-asserted-by":"publisher","first-page":"1442","DOI":"10.1038\/s41467-019-09491-5","volume":"10","author":"SH Chang","year":"2019","unstructured":"Chang SH, Mori D, Kobayashi H et al (2019) Excessive mechanical loading promotes osteoarthritis through the gremlin-1-NF-\u03baB pathway. Nat Commun 10(1):1442","journal-title":"Nat Commun"},{"issue":"1","key":"3983_CR69","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1136\/annrheumdis-2013-203901","volume":"74","author":"S Zhu","year":"2015","unstructured":"Zhu S, Lu P, Liu H et al (2015) Inhibition of Rac1 activity by controlled release of NSC23766 from chitosan microspheres effectively ameliorates osteoarthritis development in vivo. Ann Rheum Dis 74(1):285\u2013293","journal-title":"Ann Rheum Dis"},{"issue":"8","key":"3983_CR70","doi-asserted-by":"publisher","first-page":"2154","DOI":"10.1002\/art.39174","volume":"67","author":"S Zhu","year":"2015","unstructured":"Zhu S, Dai J, Liu H et al (2015) Down-regulation of Rac GTPase-activating protein OCRL1 causes aberrant activation of Rac1 in osteoarthritis development. Arthritis Rheumatol 67(8):2154\u20132163","journal-title":"Arthritis Rheumatol"},{"key":"3983_CR71","doi-asserted-by":"publisher","first-page":"539361","DOI":"10.3389\/fonc.2021.539361","volume":"11","author":"W Nasry","year":"2021","unstructured":"Nasry W, Martin CK (2021) Intersecting mechanisms of hypoxia and prostaglandin E2-mediated inflammation in the comparative biology of oral squamous cell carcinoma. Front Oncol 11:539361","journal-title":"Front Oncol"},{"issue":"4","key":"3983_CR72","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.joca.2008.09.003","volume":"17","author":"S Otsuka","year":"2009","unstructured":"Otsuka S, Aoyama T, Furu M et al (2009) PGE2 signal via EP2 receptors evoked by a selective agonist enhances regeneration of injured articular cartilage. Osteoarthr Cartil 17(4):529\u2013538","journal-title":"Osteoarthr Cartil"},{"issue":"1","key":"3983_CR73","doi-asserted-by":"publisher","first-page":"20329","DOI":"10.1038\/s41598-019-56861-6","volume":"9","author":"Y Murahashi","year":"2019","unstructured":"Murahashi Y, Yano F, Chijimatsu R et al (2019) Oral administration of EP4-selective agonist KAG-308 suppresses mouse knee osteoarthritis development through reduction of chondrocyte hypertrophy and TNF secretion. Sci Rep 9(1):20329","journal-title":"Sci Rep"},{"issue":"5","key":"3983_CR74","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1002\/jor.23781","volume":"36","author":"SM Hwang","year":"2018","unstructured":"Hwang SM, Feigenson M, Begun DL et al (2018) Phlpp inhibitors block pain and cartilage degradation associated with osteoarthritis. J Orthop Res 36(5):1487\u20131497","journal-title":"J Orthop Res"},{"issue":"3","key":"3983_CR75","doi-asserted-by":"publisher","first-page":"97","DOI":"10.4081\/reumatismo.2013.97","volume":"65","author":"L De Falco","year":"2013","unstructured":"De Falco L, Fioravanti A, Galeazzi M, Tenti S (2013) Bradykinin and its role in osteoarthritis. Reumatismo 65(3):97\u2013104","journal-title":"Reumatismo"},{"issue":"8","key":"3983_CR76","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1007\/s00011-007-7204-1","volume":"57","author":"S Meini","year":"2008","unstructured":"Meini S, Maggi CA (2008) Knee osteoarthritis: a role for bradykinin. Inflamm Res 57(8):351\u2013361","journal-title":"Inflamm Res"},{"key":"3983_CR77","doi-asserted-by":"publisher","first-page":"932691","DOI":"10.1155\/2013\/932691","volume":"2013","author":"Y Gebru","year":"2013","unstructured":"Gebru Y, Diao TY, Pan H, Mukwaya E, Zhang Y (2013) Potential of RAS inhibition to improve metabolic bone disorders. Biomed Res Int 2013:932691","journal-title":"Biomed Res Int"},{"issue":"4","key":"3983_CR78","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1007\/s00296-004-0564-8","volume":"25","author":"V Cobankara","year":"2005","unstructured":"Cobankara V, Ozt\u00fcrk MA, Kiraz S et al (2005) Renin and angiotensin-converting enzyme (ACE) as active components of the local synovial renin-angiotensin system in rheumatoid arthritis. Rheumatol Int 25(4):285\u2013291","journal-title":"Rheumatol Int"},{"issue":"2","key":"3983_CR79","doi-asserted-by":"publisher","first-page":"2387","DOI":"10.4081\/ejh.2014.2387","volume":"58","author":"I Tsukamoto","year":"2014","unstructured":"Tsukamoto I, Akagi M, Inoue S, Yamagishi K, Mori S, Asada S (2014) Expressions of local renin-angiotensin system components in chondrocytes. Eur J Histochem 58(2):2387","journal-title":"Eur J Histochem"},{"issue":"4","key":"3983_CR80","doi-asserted-by":"publisher","first-page":"3965","DOI":"10.3892\/mmr.2017.7110","volume":"16","author":"K Yan","year":"2017","unstructured":"Yan K, Shen Y (2017) Aliskiren has chondroprotective efficacy in a rat model of osteoarthritis through suppression of the local renin-angiotensin system. Mol Med Rep 16(4):3965\u20133973","journal-title":"Mol Med Rep"},{"issue":"1","key":"3983_CR81","doi-asserted-by":"publisher","first-page":"16983","DOI":"10.1038\/s41598-017-17289-y","volume":"7","author":"H Makino","year":"2017","unstructured":"Makino H, Seki S, Yahara Y et al (2017) A selective inhibition of c-Fos\/activator protein-1 as a potential therapeutic target for intervertebral disc degeneration and associated pain. Sci Rep 7(1):16983","journal-title":"Sci Rep"},{"issue":"2","key":"3983_CR82","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1254\/jphs.11014FP","volume":"116","author":"H Lim","year":"2011","unstructured":"Lim H, Park H, Kim HP (2011) Effects of flavonoids on matrix metalloproteinase-13 expression of interleukin-1\u03b2-treated articular chondrocytes and their cellular mechanisms: inhibition of c-Fos\/AP-1 and JAK\/STAT signaling pathways. J Pharmacol Sci 116(2):221\u2013231","journal-title":"J Pharmacol Sci"},{"issue":"7","key":"3983_CR83","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1038\/nbt1412","volume":"26","author":"Y Aikawa","year":"2008","unstructured":"Aikawa Y, Morimoto K, Yamamoto T et al (2008) Treatment of arthritis with a selective inhibitor of c-Fos\/activator protein-1. Nat Biotechnol 26(7):817\u2013823","journal-title":"Nat Biotechnol"},{"issue":"2","key":"3983_CR84","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1016\/j.bbrc.2018.02.147","volume":"497","author":"H Motomura","year":"2018","unstructured":"Motomura H, Seki S, Shiozawa S, Aikawa Y, Nogami M, Kimura T (2018) A selective c-Fos\/AP-1 inhibitor prevents cartilage destruction and subsequent osteophyte formation. Biochem Biophys Res Commun 497(2):756\u2013761","journal-title":"Biochem Biophys Res Commun"},{"key":"3983_CR85","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/s13063-015-0602-8","volume":"16","author":"SR Kingsbury","year":"2015","unstructured":"Kingsbury SR, Tharmanathan P, Arden NK et al (2015) Pain reduction with oral methotrexate in knee osteoarthritis, a pragmatic phase iii trial of treatment effectiveness (PROMOTE): study protocol for a randomized controlled trial. Trials 16:77","journal-title":"Trials"},{"issue":"2","key":"3983_CR86","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1111\/bcp.12094","volume":"77","author":"M Niesters","year":"2014","unstructured":"Niesters M, Martini C, Dahan A (2014) Ketamine for chronic pain: risks and benefits. Br J Clin Pharmacol 77(2):357\u2013367","journal-title":"Br J Clin Pharmacol"},{"issue":"8","key":"3983_CR87","doi-asserted-by":"publisher","first-page":"2523","DOI":"10.1002\/art.22829","volume":"56","author":"S Flood","year":"2007","unstructured":"Flood S, Parri R, Williams A, Duance V, Mason D (2007) Modulation of interleukin-6 and matrix metalloproteinase 2 expression in human fibroblast-like synoviocytes by functional ionotropic glutamate receptors. Arthritis Rheum 56(8):2523\u20132534","journal-title":"Arthritis Rheum"},{"issue":"6","key":"3983_CR88","doi-asserted-by":"publisher","first-page":"5013","DOI":"10.3892\/mmr.2016.5164","volume":"13","author":"W Lu","year":"2016","unstructured":"Lu W, Wang L, Wo C, Yao J (2016) Ketamine attenuates osteoarthritis of the knee via modulation of inflammatory responses in a rabbit model. Mol Med Rep 13(6):5013\u20135020","journal-title":"Mol Med Rep"},{"issue":"52","key":"3983_CR89","doi-asserted-by":"publisher","first-page":"89475","DOI":"10.18632\/oncotarget.18324","volume":"8","author":"JE Lee","year":"2017","unstructured":"Lee JE, Lee JM, Park YJ, Kim BS, Jeon YT, Chung Y (2017) Inhibition of autoimmune Th17 cell responses by pain killer ketamine. Oncotarget 8(52):89475\u201389485","journal-title":"Oncotarget"},{"issue":"1","key":"3983_CR90","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1038\/s41413-020-00109-x","volume":"8","author":"C Yuan","year":"2020","unstructured":"Yuan C, Pan Z, Zhao K et al (2020) Classification of four distinct osteoarthritis subtypes with a knee joint tissue transcriptome atlas. Bone Res 8(1):38","journal-title":"Bone Res"},{"issue":"3","key":"3983_CR91","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1002\/art.38965","volume":"67","author":"BJ de Lange-Brokaar","year":"2015","unstructured":"de Lange-Brokaar BJ, Ioan-Facsinay A, Yusuf E et al (2015) Association of pain in knee osteoarthritis with distinct patterns of synovitis. Arthritis Rheumatol 67(3):733\u2013740","journal-title":"Arthritis Rheumatol"},{"issue":"11","key":"3983_CR92","doi-asserted-by":"publisher","first-page":"1858","DOI":"10.1016\/j.joca.2015.05.017","volume":"23","author":"A Yusup","year":"2015","unstructured":"Yusup A, Kaneko H, Liu L et al (2015) Bone marrow lesions, subchondral bone cysts and subchondral bone attrition are associated with histological synovitis in patients with end-stage knee osteoarthritis: a cross-sectional study. Osteoarthr Cartil 23(11):1858\u20131864","journal-title":"Osteoarthr Cartil"},{"issue":"3","key":"3983_CR93","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1002\/art.39488","volume":"68","author":"T Neogi","year":"2016","unstructured":"Neogi T, Guermazi A, Roemer F et al (2016) Association of joint inflammation with pain sensitization in knee osteoarthritis: the multicenter osteoarthritis study. Arthritis Rheumatol 68(3):654\u2013661","journal-title":"Arthritis Rheumatol"},{"issue":"6","key":"3983_CR94","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/s41584-019-0221-y","volume":"15","author":"PG Conaghan","year":"2019","unstructured":"Conaghan PG, Cook AD, Hamilton JA, Tak PP (2019) Therapeutic options for targeting inflammatory osteoarthritis pain. Nat Rev Rheumatol 15(6):355\u2013363","journal-title":"Nat Rev Rheumatol"},{"issue":"2","key":"3983_CR95","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1038\/s41584-018-0123-4","volume":"15","author":"IA Jones","year":"2019","unstructured":"Jones IA, Togashi R, Wilson ML, Heckmann N, Vangsness CT Jr (2019) Intra-articular treatment options for knee osteoarthritis. Nat Rev Rheumatol 15(2):77\u201390","journal-title":"Nat Rev Rheumatol"},{"key":"3983_CR96","first-page":"CD005328","volume":"10","author":"P J\u00fcni","year":"2015","unstructured":"J\u00fcni P, Hari R, Rutjes AW et al (2015) Intra-articular corticosteroid for knee osteoarthritis. Cochrane Database Syst Rev 10:CD005328","journal-title":"Cochrane Database Syst Rev"},{"issue":"5","key":"3983_CR97","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1002\/acr.23884","volume":"72","author":"MC Osani","year":"2020","unstructured":"Osani MC, Vaysbrot EE, Zhou M, McAlindon TE, Bannuru RR (2020) Duration of symptom relief and early trajectory of adverse events for oral nonsteroidal antiinflammatory drugs in knee osteoarthritis: a systematic review and meta-analysis. Arthritis Care Res (Hoboken) 72(5):641\u2013651","journal-title":"Arthritis Care Res (Hoboken)"},{"issue":"12","key":"3983_CR98","doi-asserted-by":"publisher","first-page":"2286","DOI":"10.1093\/rheumatology\/kes219","volume":"51","author":"CY Wenham","year":"2012","unstructured":"Wenham CY, Hensor EM, Grainger AJ et al (2012) A randomized, double-blind, placebo-controlled trial of low-dose oral prednisolone for treating painful hand osteoarthritis. Rheumatol (Oxf) 51(12):2286\u20132294","journal-title":"Rheumatol (Oxf)"},{"issue":"19","key":"3983_CR99","doi-asserted-by":"publisher","first-page":"1967","DOI":"10.1001\/jama.2017.5283","volume":"317","author":"TE McAlindon","year":"2017","unstructured":"McAlindon TE, LaValley MP, Harvey WF et al (2017) Effect of intra-articular triamcinolone vs saline on knee cartilage volume and pain in patients with knee osteoarthritis: a randomized clinical trial. JAMA 317(19):1967\u20131975","journal-title":"JAMA"},{"issue":"32","key":"3983_CR100","doi-asserted-by":"publisher","first-page":"19471","DOI":"10.1074\/jbc.R115.654764","volume":"290","author":"BL Roth","year":"2015","unstructured":"Roth BL, Kroeze WK (2015) Integrated approaches for genome-wide interrogation of the druggable non-olfactory g protein-coupled receptor superfamily. J Biol Chem 290(32):19471\u201319477","journal-title":"J Biol Chem"},{"issue":"Suppl_4","key":"3983_CR101","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1093\/rheumatology\/kex522","volume":"57","author":"RE Miller","year":"2018","unstructured":"Miller RE, Block JA, Malfait AM (2018) What is new in pain modification in osteoarthritis. Rheumatol (Oxf) 57(Suppl_4):99\u2013107","journal-title":"Rheumatol (Oxf)"},{"key":"3983_CR102","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1007\/978-3-662-44605-8_16","volume":"226","author":"A Cowan","year":"2015","unstructured":"Cowan A, Kehner GB, Inan S (2015) Targeting itch with ligands selective for \u03ba opioid receptors. Handb Exp Pharmacol 226:291\u2013314","journal-title":"Handb Exp Pharmacol"},{"issue":"31","key":"3983_CR103","doi-asserted-by":"publisher","first-page":"2878","DOI":"10.2174\/1568026620666200508082615","volume":"20","author":"N Kiguchi","year":"2020","unstructured":"Kiguchi N, Ding H, Kishioka S, Ko MC (2020) Nociceptin\/Orphanin FQ peptide receptor-related ligands as novel analgesics. Curr Top Med Chem 20(31):2878\u20132888","journal-title":"Curr Top Med Chem"},{"issue":"3","key":"3983_CR104","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1016\/j.jpainsymman.2019.05.012","volume":"58","author":"ED Koch","year":"2019","unstructured":"Koch ED, Kapanadze S, Eerdekens MH et al (2019) Cebranopadol, a novel first-in-class analgesic drug candidate: first experience with cancer-related pain for up to 26 weeks. J Pain Symptom Manage 58(3):390\u2013399","journal-title":"J Pain Symptom Manage"},{"issue":"3","key":"3983_CR105","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1021\/jm3011433","volume":"56","author":"SK Bagal","year":"2013","unstructured":"Bagal SK, Brown AD, Cox PJ et al (2013) Ion channels as therapeutic targets: a drug discovery perspective. J Med Chem 56(3):593\u2013624","journal-title":"J Med Chem"},{"issue":"6","key":"3983_CR106","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1007\/s11914-016-0326-z","volume":"14","author":"AM Malfait","year":"2016","unstructured":"Malfait AM, Miller RJ (2016) Emerging targets for the management of osteoarthritis pain. Curr Osteoporos Rep 14(6):260\u2013268","journal-title":"Curr Osteoporos Rep"},{"key":"3983_CR107","doi-asserted-by":"crossref","unstructured":"R Stevens DP, J Ervin JN, Nieves Y (2017) OP0167 efficacy and safety of CNTX-4975 in subjects with moderate to severe osteoarthritis knee pain: 24-week, randomized, double-blind, placebo-controlled, dose","DOI":"10.1136\/annrheumdis-2017-eular.5309"},{"key":"3983_CR108","doi-asserted-by":"publisher","first-page":"349","DOI":"10.3389\/fnmol.2017.00349","volume":"10","author":"A Eitner","year":"2017","unstructured":"Eitner A, Hofmann GO, Schaible HG (2017) Mechanisms of osteoarthritic pain studies in humans and experimental models. Front Mol Neurosci 10:349","journal-title":"Front Mol Neurosci"},{"issue":"5","key":"3983_CR109","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1038\/nrrheum.2017.50","volume":"13","author":"A Mobasheri","year":"2017","unstructured":"Mobasheri A, Rayman MP, Gualillo O, Sellam J, van der Kraan P, Fearon U (2017) The role of metabolism in the pathogenesis of osteoarthritis. Nat Rev Rheumatol 13(5):302\u2013311","journal-title":"Nat Rev Rheumatol"},{"issue":"12","key":"3983_CR110","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1038\/nrrheum.2012.135","volume":"8","author":"Q Zhuo","year":"2012","unstructured":"Zhuo Q, Yang W, Chen J, Wang Y (2012) Metabolic syndrome meets osteoarthritis. Nat Rev Rheumatol 8(12):729\u2013737","journal-title":"Nat Rev Rheumatol"},{"key":"3983_CR111","doi-asserted-by":"publisher","first-page":"5468023","DOI":"10.1155\/2017\/5468023","volume":"2017","author":"D Azamar-Llamas","year":"2017","unstructured":"Azamar-Llamas D, Hern\u00e1ndez-Molina G, Ramos-\u00c1valos B, Furuzawa-Carballeda J (2017) Adipokine contribution to the pathogenesis of osteoarthritis. Mediators Inflamm 2017:5468023","journal-title":"Mediators Inflamm"},{"issue":"12","key":"3983_CR112","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1097\/GME.0000000000001412","volume":"26","author":"SS Faubion","year":"2019","unstructured":"Faubion SS, Kapoor E, Moyer AM, Hodis HN, Miller VM (2019) Statin therapy: does sex matter. Menopause 26(12):1425\u20131435","journal-title":"Menopause"},{"issue":"7519","key":"3983_CR113","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1038\/nature13775","volume":"513","author":"A Yamashita","year":"2014","unstructured":"Yamashita A, Morioka M, Kishi H et al (2014) Statin treatment rescues FGFR3 skeletal dysplasia phenotypes. Nature 513(7519):507\u2013511","journal-title":"Nature"},{"issue":"3\u20134","key":"3983_CR114","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1007\/s00011-014-0794-5","volume":"64","author":"NN Pathak","year":"2015","unstructured":"Pathak NN, Lingaraju MC, Balaganur V et al (2015) Anti-inflammatory and chondroprotective effects of atorvastatin in a cartilage explant model of osteoarthritis. Inflamm Res 64(3\u20134):161\u2013169","journal-title":"Inflamm Res"},{"issue":"12","key":"3983_CR115","doi-asserted-by":"publisher","first-page":"990","DOI":"10.18632\/aging.100213","volume":"2","author":"K Yudoh","year":"2010","unstructured":"Yudoh K, Karasawa R (2010) Statin prevents chondrocyte aging and degeneration of articular cartilage in osteoarthritis (OA). Aging (Albany NY) 2(12):990\u2013998","journal-title":"Aging (Albany NY)"},{"issue":"5","key":"3983_CR116","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/j.jbspin.2017.09.014","volume":"85","author":"F Eymard","year":"2018","unstructured":"Eymard F, Parsons C, Edwards MH et al (2018) Statin use and knee osteoarthritis progression: results from a post-hoc analysis of the SEKOIA trial. Jt Bone Spine 85(5):609\u2013614","journal-title":"Jt Bone Spine"},{"issue":"8","key":"3983_CR117","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1002\/acr.23735","volume":"71","author":"N Veronese","year":"2019","unstructured":"Veronese N, Koyanagi A, Stubbs B et al (2019) Statin use and knee osteoarthritis outcomes: a longitudinal cohort study. Arthritis Care Res (Hoboken) 71(8):1052\u20131058","journal-title":"Arthritis Care Res (Hoboken)"},{"issue":"2","key":"3983_CR118","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1148\/radiol.2019190557","volume":"293","author":"A Haj-Mirzaian","year":"2019","unstructured":"Haj-Mirzaian A, Mohajer B, Guermazi A et al (2019) Statin use and knee osteoarthritis outcome measures according to the presence of heberden nodes: results from the osteoarthritis initiative. Radiology 293(2):396\u2013404","journal-title":"Radiology"},{"issue":"4","key":"3983_CR119","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.tem.2016.12.005","volume":"28","author":"J Misra","year":"2017","unstructured":"Misra J, Kim DK, Choi HS (2017) ERR\u03b3: a junior orphan with a senior role in metabolism. Trends Endocrinol Metab 28(4):261\u2013272","journal-title":"Trends Endocrinol Metab"},{"issue":"1","key":"3983_CR120","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1038\/aps.2014.121","volume":"36","author":"\u00c9 Audet-Walsh","year":"2015","unstructured":"Audet-Walsh \u00c9, Gigu\u00e9re V (2015) The multiple universes of estrogen-related receptor \u03b1 and \u03b3 in metabolic control and related diseases. Acta Pharmacol Sin 36(1):51\u201361","journal-title":"Acta Pharmacol Sin"},{"issue":"1","key":"3983_CR121","doi-asserted-by":"publisher","first-page":"2133","DOI":"10.1038\/s41467-017-01868-8","volume":"8","author":"YO Son","year":"2017","unstructured":"Son YO, Park S, Kwak JS et al (2017) Estrogen-related receptor \u03b3 causes osteoarthritis by upregulating extracellular matrix-degrading enzymes. Nat Commun 8(1):2133","journal-title":"Nat Commun"},{"key":"3983_CR122","doi-asserted-by":"publisher","first-page":"118602","DOI":"10.1016\/j.lfs.2020.118602","volume":"263","author":"Y He","year":"2020","unstructured":"He Y, Makarczyk MJ, Lin H (2020) Role of mitochondria in mediating chondrocyte response to mechanical stimuli. Life Sci 263:118602","journal-title":"Life Sci"},{"key":"3983_CR123","doi-asserted-by":"publisher","first-page":"101249","DOI":"10.1016\/j.arr.2020.101249","volume":"66","author":"L Zheng","year":"2021","unstructured":"Zheng L, Zhang Z, Sheng P, Mobasheri A (2021) The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis. Ageing Res Rev 66:101249","journal-title":"Ageing Res Rev"},{"issue":"5","key":"3983_CR124","doi-asserted-by":"publisher","first-page":"2477","DOI":"10.3390\/ijms22052477","volume":"22","author":"A Eitner","year":"2021","unstructured":"Eitner A, M\u00fcller S, K\u00f6nig C et al (2021) Inhibition of inducible nitric oxide synthase prevents IL-1\u03b2-induced mitochondrial dysfunction in human chondrocytes. Int J Mol Sci 22(5):2477","journal-title":"Int J Mol Sci"},{"issue":"5","key":"3983_CR125","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1007\/s10495-007-0756-2","volume":"12","author":"M Ott","year":"2007","unstructured":"Ott M, Gogvadze V, Orrenius S, Zhivotovsky B (2007) Mitochondria, oxidative stress and cell death. Apoptosis 12(5):913\u2013922","journal-title":"Apoptosis"},{"issue":"2","key":"3983_CR126","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3109\/19390211.2015.1008611","volume":"13","author":"Y Panahi","year":"2016","unstructured":"Panahi Y, Alishiri GH, Parvin S, Sahebkar A (2016) Mitigation of systemic oxidative stress by curcuminoids in osteoarthritis: results of a randomized controlled trial. J Diet Suppl 13(2):209\u2013220","journal-title":"J Diet Suppl"},{"issue":"1","key":"3983_CR127","doi-asserted-by":"publisher","first-page":"1914","DOI":"10.1038\/s41467-019-09839-x","volume":"10","author":"Y Shi","year":"2019","unstructured":"Shi Y, Hu X, Cheng J et al (2019) A small molecule promotes cartilage extracellular matrix generation and inhibits osteoarthritis development. Nat Commun 10(1):1914","journal-title":"Nat Commun"},{"key":"3983_CR128","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.biopha.2017.12.113","volume":"99","author":"D Choudhary","year":"2018","unstructured":"Choudhary D, Adhikary S, Ahmad N et al (2018) Prevention of articular cartilage degeneration in a rat model of monosodium iodoacetate induced osteoarthritis by oral treatment with Withaferin A. Biomed Pharmacother 99:151\u2013161","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"3983_CR129","doi-asserted-by":"publisher","first-page":"C111","DOI":"10.1152\/ajpcell.00261.2018","volume":"317","author":"D Bloemberg","year":"2019","unstructured":"Bloemberg D, Quadrilatero J (2019) Autophagy, apoptosis, and mitochondria: molecular integration and physiological relevance in skeletal muscle. Am J Physiol Cell Physiol 317(1):C111\u2013C130","journal-title":"Am J Physiol Cell Physiol"},{"issue":"5","key":"3983_CR130","doi-asserted-by":"publisher","first-page":"2700","DOI":"10.3390\/ijms22052700","volume":"22","author":"MT Valenti","year":"2021","unstructured":"Valenti MT, Dalle Carbonare L, Zipeto D, Mottes M (2021) Control of the autophagy pathway in osteoarthritis: key regulators, therapeutic targets and therapeutic strategies. Int J Mol Sci 22(5):2700","journal-title":"Int J Mol Sci"},{"issue":"Pt 18","key":"3983_CR131","doi-asserted-by":"publisher","first-page":"3125","DOI":"10.1242\/jeb.01133","volume":"207","author":"Q Chen","year":"2004","unstructured":"Chen Q, Haddad GG (2004) Role of trehalose phosphate synthase and trehalose during hypoxia: from flies to mammals. J Exp Biol 207(Pt 18):3125\u20133129","journal-title":"J Exp Biol"},{"issue":"10","key":"3983_CR132","doi-asserted-by":"publisher","first-page":"e3081","DOI":"10.1038\/cddis.2017.453","volume":"8","author":"Q Tang","year":"2017","unstructured":"Tang Q, Zheng G, Feng Z et al (2017) Trehalose ameliorates oxidative stress-mediated mitochondrial dysfunction and ER stress via selective autophagy stimulation and autophagic flux restoration in osteoarthritis development. Cell Death Dis 8(10):e3081","journal-title":"Cell Death Dis"},{"issue":"8","key":"3983_CR133","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1038\/nm.4132","volume":"22","author":"D Ryu","year":"2016","unstructured":"Ryu D, Mouchiroud L, Andreux PA et al (2016) Urolithin A induces mitophagy and prolongs lifespan in C elegans and increases muscle function in rodents. Nat Med 22(8):879\u2013888","journal-title":"Nat Med"},{"key":"3983_CR134","doi-asserted-by":"publisher","first-page":"703847","DOI":"10.3389\/fphar.2021.703847","volume":"12","author":"Y He","year":"2021","unstructured":"He Y, Yocum L, Alexander PG, Jurczak MJ, Lin H (2021) Urolithin A protects chondrocytes from mechanical overloading-induced injuries. Front Pharmacol 12:703847","journal-title":"Front Pharmacol"},{"issue":"1","key":"3983_CR135","doi-asserted-by":"publisher","first-page":"17","DOI":"10.21037\/atm.2019.10.113","volume":"8","author":"L Zhang","year":"2020","unstructured":"Zhang L, Zhang Z, Khan A, Zheng H, Yuan C, Jiang H (2020) Advances in drug therapy for mitochondrial diseases. Ann Transl Med 8(1):17","journal-title":"Ann Transl Med"},{"issue":"1","key":"3983_CR136","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1186\/s13054-015-1056-9","volume":"19","author":"FA Harms","year":"2015","unstructured":"Harms FA, Bodmer SI, Raat NJ, Mik EG (2015) Non-invasive monitoring of mitochondrial oxygenation and respiration in critical illness using a novel technique. Crit Care 19(1):343","journal-title":"Crit Care"},{"issue":"5","key":"3983_CR137","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1002\/jbmr.1843","volume":"28","author":"KI Kim","year":"2013","unstructured":"Kim KI, Park YS, Im GI (2013) Changes in the epigenetic status of the SOX-9 promoter in human osteoarthritic cartilage. J Bone Miner Res 28(5):1050\u20131060","journal-title":"J Bone Miner Res"},{"issue":"7","key":"3983_CR138","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1136\/annrheumdis-2016-210407","volume":"76","author":"J Dai","year":"2017","unstructured":"Dai J, Yu D, Wang Y et al (2017) Kdm6b regulates cartilage development and homeostasis through anabolic metabolism. Ann Rheum Dis 76(7):1295\u20131303","journal-title":"Ann Rheum Dis"},{"key":"3983_CR139","doi-asserted-by":"publisher","first-page":"29176","DOI":"10.1038\/srep29176","volume":"6","author":"L Chen","year":"2016","unstructured":"Chen L, Wu Y, Wu Y, Wang Y, Sun L, Li F (2016) The inhibition of EZH2 ameliorates osteoarthritis development through the Wnt\/\u03b2-catenin pathway. Sci Rep 6:29176","journal-title":"Sci Rep"},{"issue":"1","key":"3983_CR140","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1186\/s13075-016-1053-7","volume":"18","author":"C Yapp","year":"2016","unstructured":"Yapp C, Carr AJ, Price A, Oppermann U, Snelling SJ (2016) H3K27me3 demethylases regulate in vitro chondrogenesis and chondrocyte activity in osteoarthritis. Arthritis Res Ther 18(1):158","journal-title":"Arthritis Res Ther"},{"key":"3983_CR141","doi-asserted-by":"publisher","first-page":"15889","DOI":"10.1038\/ncomms15889","volume":"8","author":"S Monteagudo","year":"2017","unstructured":"Monteagudo S, Cornelis F, Aznar-Lopez C et al (2017) DOT1L safeguards cartilage homeostasis and protects against osteoarthritis. Nat Commun 8:15889","journal-title":"Nat Commun"},{"issue":"10","key":"3983_CR142","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1038\/s41580-019-0151-1","volume":"20","author":"A Jambhekar","year":"2019","unstructured":"Jambhekar A, Dhall A, Shi Y (2019) Roles and regulation of histone methylation in animal development. Nat Rev Mol Cell Biol 20(10):625\u2013641","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"5","key":"3983_CR143","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1002\/jbmr.3952","volume":"35","author":"X Du","year":"2020","unstructured":"Du X, Chen Y, Zhang Q et al (2020) Ezh2 ameliorates osteoarthritis by activating TNFSF13B. J Bone Miner Res 35(5):956\u2013965","journal-title":"J Bone Miner Res"},{"issue":"7","key":"3983_CR144","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1007\/s00011-020-01356-8","volume":"69","author":"Z Jun","year":"2020","unstructured":"Jun Z, Xinmeng J, Yue L et al (2020) Jumonji domain containing-3 (JMJD3) inhibition attenuates IL-1\u03b2-induced chondrocytes damage in vitro and protects osteoarthritis cartilage in vivo. Inflamm Res 69(7):657\u2013666","journal-title":"Inflamm Res"},{"key":"3983_CR145","doi-asserted-by":"publisher","first-page":"7402947","DOI":"10.1155\/2018\/7402947","volume":"2018","author":"M De Santis","year":"2018","unstructured":"De Santis M, Di Matteo B, Chisari E et al (2018) The role of Wnt pathway in the pathogenesis of OA and its potential therapeutic implications in the field of regenerative medicine. Biomed Res Int 2018:7402947","journal-title":"Biomed Res Int"},{"issue":"5","key":"3983_CR146","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/j.berh.2018.03.004","volume":"31","author":"A Stampella","year":"2017","unstructured":"Stampella A, Monteagudo S, Lories R (2017) Wnt signaling as target for the treatment of osteoarthritis. Best Pract Res Clin Rheumatol 31(5):721\u2013729","journal-title":"Best Pract Res Clin Rheumatol"},{"issue":"5","key":"3983_CR147","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/j.devcel.2005.03.016","volume":"8","author":"TF Day","year":"2005","unstructured":"Day TF, Guo X, Garrett-Beal L, Yang Y (2005) Wnt\/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis. Dev Cell 8(5):739\u2013750","journal-title":"Dev Cell"},{"issue":"1","key":"3983_CR148","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.joca.2017.08.015","volume":"26","author":"V Deshmukh","year":"2018","unstructured":"Deshmukh V, Hu H, Barroga C et al (2018) A small-molecule inhibitor of the Wnt pathway (SM04690) as a potential disease modifying agent for the treatment of osteoarthritis of the knee. Osteoarthr Cartil 26(1):18\u201327","journal-title":"Osteoarthr Cartil"},{"issue":"9","key":"3983_CR149","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1016\/j.joca.2019.05.006","volume":"27","author":"VO Deshmukh","year":"2019","unstructured":"Deshmukh VO, Green AL et al (2019) Modulation of the Wnt pathway through inhibition of CLK2 and DYRK1A by lorecivivint as a novel, potentially disease-modifying approach for knee osteoarthritis treatment. Osteoarthr Cartil 27(9):1347\u20131360","journal-title":"Osteoarthr Cartil"},{"issue":"2","key":"3983_CR150","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1007\/s40744-021-00316-w","volume":"8","author":"J Tambiah","year":"2021","unstructured":"Tambiah J, Kennedy S, Swearingen CJ et al (2021) Individual participant symptom responses to intra-articular lorecivivint in knee osteoarthritis: post hoc analysis of a phase 2B trial. Rheumatol Ther 8(2):973\u2013985","journal-title":"Rheumatol Ther"},{"issue":"10","key":"3983_CR151","doi-asserted-by":"publisher","first-page":"1694","DOI":"10.1002\/art.41315","volume":"72","author":"Y Yazici","year":"2020","unstructured":"Yazici Y, McAlindon TE, Gibofsky A et al (2020) Lorecivivint, a novel intraarticular CDC-like kinase 2 and dual-specificity tyrosine phosphorylation-regulated kinase 1A inhibitor and wnt pathway modulator for the treatment of knee osteoarthritis: a phase II randomized trial. Arthritis Rheumatol 72(10):1694\u20131706","journal-title":"Arthritis Rheumatol"},{"key":"3983_CR152","doi-asserted-by":"crossref","unstructured":"Goswami VG, Patel BD (2021) Recent updates on Wnt signaling modulators: a patent review (2014\u20132020). Expert Opin Ther Pat 1\u201335","DOI":"10.1080\/13543776.2021.1940138"},{"issue":"12","key":"3983_CR153","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1080\/13543784.2020.1842357","volume":"29","author":"M Sabha","year":"2020","unstructured":"Sabha M, Siaton BC, Hochberg MC (2020) Lorecivivint, an intra-articular potential disease-modifying osteoarthritis drug. Expert Opin Investig Drugs 29(12):1339\u20131346","journal-title":"Expert Opin Investig Drugs"},{"key":"3983_CR154","doi-asserted-by":"crossref","unstructured":"Lietman C, Wu B, Lechner S et al (2018) Inhibition of Wnt\/\u03b2-catenin signaling ameliorates osteoarthritis in a murine model of experimental osteoarthritis. JCI Insight 3(3)","DOI":"10.1172\/jci.insight.96308"},{"issue":"3","key":"3983_CR155","doi-asserted-by":"publisher","first-page":"R60","DOI":"10.1186\/ar4233","volume":"15","author":"JB Shepard","year":"2013","unstructured":"Shepard JB, Jeong JW, Maihle NJ, O\u2019Brien S, Dealy CN (2013) Transient anabolic effects accompany epidermal growth factor receptor signal activation in articular cartilage in vivo. Arthritis Res Ther 15(3):R60","journal-title":"Arthritis Res Ther"},{"issue":"10","key":"3983_CR156","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1016\/j.joca.2016.05.013","volume":"24","author":"SY Shin","year":"2016","unstructured":"Shin SY, Pozzi A, Boyd SK, Clark AL (2016) Integrin \u03b11\u03b21 protects against signs of post-traumatic osteoarthritis in the female murine knee partially via regulation of epidermal growth factor receptor signalling. Osteoarthr Cartil 24(10):1795\u20131806","journal-title":"Osteoarthr Cartil"},{"issue":"7","key":"3983_CR157","doi-asserted-by":"publisher","first-page":"2590","DOI":"10.1073\/pnas.1400744111","volume":"111","author":"B Staal","year":"2014","unstructured":"Staal B, Williams BO, Beier F, Vande Woude GF, Zhang YW (2014) Cartilage-specific deletion of Mig-6 results in osteoarthritis-like disorder with excessive articular chondrocyte proliferation. Proc Natl Acad Sci U S A 111(7):2590\u20132595","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"11","key":"3983_CR158","doi-asserted-by":"publisher","first-page":"2622","DOI":"10.1002\/jbmr.502","volume":"26","author":"X Zhang","year":"2011","unstructured":"Zhang X, Siclari VA, Lan S et al (2011) The critical role of the epidermal growth factor receptor in endochondral ossification. J Bone Miner Res 26(11):2622\u20132633","journal-title":"J Bone Miner Res"},{"key":"3983_CR159","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.ebiom.2018.06.002","volume":"32","author":"H Sun","year":"2018","unstructured":"Sun H, Wu Y, Pan Z et al (2018) Gefitinib for epidermal growth factor receptor activated osteoarthritis subpopulation treatment. EBioMedicine 32:223\u2013233","journal-title":"EBioMedicine"},{"issue":"50","key":"3983_CR160","doi-asserted-by":"publisher","first-page":"14360","DOI":"10.1073\/pnas.1608938113","volume":"113","author":"H Jia","year":"2016","unstructured":"Jia H, Ma X, Tong W et al (2016) EGFR signaling is critical for maintaining the superficial layer of articular cartilage and preventing osteoarthritis initiation. Proc Natl Acad Sci USA 113(50):14360\u201314365","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"3983_CR161","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1038\/nm.3143","volume":"19","author":"G Zhen","year":"2013","unstructured":"Zhen G, Wen C, Jia X et al (2013) Inhibition of TGF-\u03b2 signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis. Nat Med 19(6):704\u2013712","journal-title":"Nat Med"},{"issue":"3","key":"3983_CR162","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1080\/13543784.2017.1283403","volume":"26","author":"W Han","year":"2017","unstructured":"Han W, Fan S, Bai X, Ding C (2017) Strontium ranelate, a promising disease modifying osteoarthritis drug. Expert Opin Investig Drugs 26(3):375\u2013380","journal-title":"Expert Opin Investig Drugs"},{"issue":"2","key":"3983_CR163","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1136\/annrheumdis-2012-202453","volume":"72","author":"FP Lafeber","year":"2013","unstructured":"Lafeber FP, van Laar JM (2013) Strontium ranelate: ready for clinical use as disease-modifying osteoarthritis drug. Ann Rheum Dis 72(2):157\u2013161","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"3983_CR164","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1136\/annrheumdis-2012-202231","volume":"72","author":"JY Reginster","year":"2013","unstructured":"Reginster JY, Badurski J, Bellamy N et al (2013) Efficacy and safety of strontium ranelate in the treatment of knee osteoarthritis: results of a double-blind, randomised placebo-controlled trial. Ann Rheum Dis 72(2):179\u2013186","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"3983_CR165","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1186\/s12891-017-1399-2","volume":"18","author":"JG Chu","year":"2017","unstructured":"Chu JG, Dai MW, Wang Y et al (2017) Strontium ranelate causes osteophytes overgrowth in a model of early phase osteoarthritis. BMC Musculoskelet Disord 18(1):78","journal-title":"BMC Musculoskelet Disord"},{"issue":"1","key":"3983_CR166","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1002\/jor.23005","volume":"34","author":"E Kozawa","year":"2016","unstructured":"Kozawa E, Cheng XW, Urakawa H et al (2016) Increased expression and activation of cathepsin K in human osteoarthritic cartilage and synovial tissues. J Orthop Res 34(1):127\u2013134","journal-title":"J Orthop Res"},{"issue":"12","key":"3983_CR167","first-page":"799","volume":"12","author":"EM Lewiecki","year":"2009","unstructured":"Lewiecki EM (2009) Odanacatib, a cathepsin K inhibitor for the treatment of osteoporosis and other skeletal disorders associated with excessive bone remodeling. IDrugs 12(12):799\u2013809","journal-title":"IDrugs"},{"key":"3983_CR168","doi-asserted-by":"publisher","first-page":"433","DOI":"10.3389\/fcell.2020.00433","volume":"8","author":"R Dai","year":"2020","unstructured":"Dai R, Wu Z, Chu HY et al (2020) Cathepsin K: the action in and beyond bone. Front Cell Dev Biol 8:433","journal-title":"Front Cell Dev Biol"},{"issue":"6","key":"3983_CR169","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.1002\/art.34453","volume":"64","author":"RF Loeser","year":"2012","unstructured":"Loeser RF, Goldring SR, Scanzello CR, Goldring MB (2012) Osteoarthritis: a disease of the joint as an organ. Arthritis Rheum 64(6):1697\u20131707","journal-title":"Arthritis Rheum"},{"key":"3983_CR170","doi-asserted-by":"publisher","first-page":"662381","DOI":"10.3389\/fbioe.2021.662381","volume":"9","author":"H Li","year":"2021","unstructured":"Li H, Liao Z, Yang Z et al (2021) 3D printed poly(\u03b5-Caprolactone)\/meniscus extracellular matrix composite scaffold functionalized with kartogenin-releasing PLGA microspheres for meniscus tissue engineering. Front Bioeng Biotechnol 9:662381","journal-title":"Front Bioeng Biotechnol"},{"issue":"10","key":"3983_CR171","doi-asserted-by":"publisher","first-page":"3568","DOI":"10.1016\/j.bioactmat.2021.03.018","volume":"6","author":"C Yu","year":"2021","unstructured":"Yu C, Li D, Wang C et al (2021) Injectable kartogenin and apocynin loaded micelle enhances the alleviation of intervertebral disc degeneration by adipose-derived stem cell. Bioact Mater 6(10):3568\u20133579","journal-title":"Bioact Mater"},{"key":"3983_CR172","doi-asserted-by":"publisher","first-page":"6640424","DOI":"10.1155\/2021\/6640424","volume":"2021","author":"J Zhu","year":"2021","unstructured":"Zhu J, Shao J, Chen Y et al (2021) Fibrin glue-kartogenin complex promotes the regeneration of the tendon-bone interface in rotator cuff injury. Stem Cells Int 2021:6640424","journal-title":"Stem Cells Int"},{"issue":"5","key":"3983_CR173","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/nrd.2018.53","volume":"17","author":"CJ Gerry","year":"2018","unstructured":"Gerry CJ, Schreiber SL (2018) Chemical probes and drug leads from advances in synthetic planning and methodology. Nat Rev Drug Discov 17(5):333\u2013352","journal-title":"Nat Rev Drug Discov"},{"issue":"6","key":"3983_CR174","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1002\/jcb.24467","volume":"114","author":"Y Yao","year":"2013","unstructured":"Yao Y, Wang Y (2013) ATDC5: an excellent in vitro model cell line for skeletal development. J Cell Biochem 114(6):1223\u20131229","journal-title":"J Cell Biochem"},{"issue":"11","key":"3983_CR175","doi-asserted-by":"publisher","first-page":"3314","DOI":"10.1002\/art.24878","volume":"60","author":"A Kan","year":"2009","unstructured":"Kan A, Ikeda T, Saito T et al (2009) Screening of chondrogenic factors with a real-time fluorescence-monitoring cell line ATDC5-C2ER: identification of sorting nexin 19 as a novel factor. Arthritis Rheum 60(11):3314\u20133323","journal-title":"Arthritis Rheum"},{"issue":"5858","key":"3983_CR176","doi-asserted-by":"publisher","first-page":"1917","DOI":"10.1126\/science.1151526","volume":"318","author":"J Yu","year":"2007","unstructured":"Yu J, Vodyanik MA, Smuga-Otto K et al (2007) Induced pluripotent stem cell lines derived from human somatic cells. Science 318(5858):1917\u20131920","journal-title":"Science"},{"issue":"11","key":"3983_CR177","doi-asserted-by":"publisher","first-page":"3062","DOI":"10.1002\/art.38780","volume":"66","author":"VP Willard","year":"2014","unstructured":"Willard VP, Diekman BO, Sanchez-Adams J, Christoforou N, Leong KW, Guilak F (2014) Use of cartilage derived from murine induced pluripotent stem cells for osteoarthritis drug screening. Arthritis Rheumatol 66(11):3062\u20133072","journal-title":"Arthritis Rheumatol"},{"issue":"12","key":"3983_CR178","doi-asserted-by":"publisher","first-page":"1968","DOI":"10.1016\/j.joca.2013.09.004","volume":"21","author":"Y Minegishi","year":"2013","unstructured":"Minegishi Y, Hosokawa K, Tsumaki N (2013) Time-lapse observation of the dedifferentiation process in mouse chondrocytes using chondrocyte-specific reporters. Osteoarthr Cartil 21(12):1968\u20131975","journal-title":"Osteoarthr Cartil"},{"issue":"2","key":"3983_CR179","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1172\/JCI44605","volume":"121","author":"K Hiramatsu","year":"2011","unstructured":"Hiramatsu K, Sasagawa S, Outani H, Nakagawa K, Yoshikawa H, Tsumaki N (2011) Generation of hyaline cartilaginous tissue from mouse adult dermal fibroblast culture by defined factors. J Clin Invest 121(2):640\u2013657","journal-title":"J Clin Invest"},{"issue":"9","key":"3983_CR180","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1016\/j.drudis.2016.07.003","volume":"21","author":"A Skardal","year":"2016","unstructured":"Skardal A, Shupe T, Atala A (2016) Organoid-on-a-chip and body-on-a-chip systems for drug screening and disease modeling. Drug Discov Today 21(9):1399\u20131411","journal-title":"Drug Discov Today"},{"issue":"Suppl 1","key":"3983_CR181","doi-asserted-by":"publisher","first-page":"S6","DOI":"10.1186\/scrt367","volume":"4","author":"TP Lozito","year":"2013","unstructured":"Lozito TP, Alexander PG, Lin H, Gottardi R, Cheng AW, Tuan RS (2013) Three-dimensional osteochondral microtissue to model pathogenesis of osteoarthritis. Stem Cell Res Ther 4(Suppl 1):S6","journal-title":"Stem Cell Res Ther"},{"issue":"5","key":"3983_CR182","doi-asserted-by":"publisher","first-page":"647","DOI":"10.3904\/kjim.2014.29.5.647","volume":"29","author":"CH Choi","year":"2014","unstructured":"Choi CH, Kim TH, Sung YK et al (2014) SKI306X inhibition of glycosaminoglycan degradation in human cartilage involves down-regulation of cytokine-induced catabolic genes. Korean J Intern Med 29(5):647\u2013655","journal-title":"Korean J Intern Med"},{"issue":"1","key":"3983_CR183","doi-asserted-by":"publisher","first-page":"14409","DOI":"10.1038\/s41598-021-93744-1","volume":"11","author":"A Mixon","year":"2021","unstructured":"Mixon A, Savage A, Bahar-Moni AS, Adouni M, Faisal T (2021) An in vitro investigation to understand the synergistic role of MMPs-1 and 9 on articular cartilage biomechanical properties. Sci Rep 11(1):14409","journal-title":"Sci Rep"},{"issue":"4","key":"3983_CR184","doi-asserted-by":"publisher","first-page":"100099","DOI":"10.1016\/j.ocarto.2020.100099","volume":"2","author":"RM Black","year":"2020","unstructured":"Black RM, Wang Y, Struglics A et al (2020) Proteomic analysis reveals dexamethasone rescues matrix breakdown but not anabolic dysregulation in a cartilage injury model. Osteoarthr Cartil Open. 2(4):100099","journal-title":"Osteoarthr Cartil Open."},{"issue":"5","key":"3983_CR185","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1002\/cbf.3112","volume":"33","author":"J Wardale","year":"2015","unstructured":"Wardale J, Mullen L, Howard D, Ghose S, Rushton N (2015) An ex vivo model using human osteoarthritic cartilage demonstrates the release of bioactive insulin-like growth factor-1 from a collagen-glycosaminoglycan scaffold. Cell Biochem Funct 33(5):277\u2013284","journal-title":"Cell Biochem Funct"},{"issue":"2","key":"3983_CR186","doi-asserted-by":"publisher","first-page":"267","DOI":"10.14573\/altex.1607111","volume":"34","author":"A Schwab","year":"2017","unstructured":"Schwab A, Meeuwsen A, Ehlicke F et al (2017) Ex vivo culture platform for assessment of cartilage repair treatment strategies. Altex 34(2):267\u2013277","journal-title":"Altex"},{"issue":"12","key":"3983_CR187","doi-asserted-by":"publisher","first-page":"6394","DOI":"10.3390\/ijms22126394","volume":"22","author":"J Spinnen","year":"2021","unstructured":"Spinnen J, Shopperly LK, Rendenbach C et al (2021) A novel method facilitating the simple and low-cost preparation of human osteochondral slice explants for large-scale native tissue analysis. Int J Mol Sci 22(12):6394","journal-title":"Int J Mol Sci"},{"issue":"18","key":"3983_CR188","doi-asserted-by":"publisher","first-page":"16106","DOI":"10.1021\/am504135b","volume":"6","author":"C Chen","year":"2014","unstructured":"Chen C, Xie J, Deng L, Yang L (2014) Substrate stiffness together with soluble factors affects chondrocyte mechanoresponses. ACS Appl Mater Interfaces 6(18):16106\u201316116","journal-title":"ACS Appl Mater Interfaces"},{"issue":"2","key":"3983_CR189","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1177\/1759720X12467868","volume":"5","author":"J Sokolove","year":"2013","unstructured":"Sokolove J, Lepus CM (2013) Role of inflammation in the pathogenesis of osteoarthritis: latest findings and interpretations. Ther Adv Musculoskelet Dis 5(2):77\u201394","journal-title":"Ther Adv Musculoskelet Dis"},{"issue":"9","key":"3983_CR190","doi-asserted-by":"publisher","first-page":"2732","DOI":"10.1002\/art.30451","volume":"63","author":"JH Ryu","year":"2011","unstructured":"Ryu JH, Yang S, Shin Y, Rhee J, Chun CH, Chun JS (2011) Interleukin-6 plays an essential role in hypoxia-inducible factor 2\u03b1-induced experimental osteoarthritic cartilage destruction in mice. Arthritis Rheum 63(9):2732\u20132743","journal-title":"Arthritis Rheum"},{"issue":"1","key":"3983_CR191","doi-asserted-by":"publisher","first-page":"R7","DOI":"10.1186\/ar3555","volume":"14","author":"DH Sohn","year":"2012","unstructured":"Sohn DH, Sokolove J, Sharpe O et al (2012) Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4. Arthritis Res Ther 14(1):R7","journal-title":"Arthritis Res Ther"},{"key":"3983_CR192","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.tvjl.2015.07.011","volume":"209","author":"CI Johnson","year":"2016","unstructured":"Johnson CI, Argyle DJ, Clements DN (2016) In vitro models for the study of osteoarthritis. Vet J 209:40\u201349","journal-title":"Vet J"},{"issue":"1","key":"3983_CR193","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/s00264-012-1724-1","volume":"37","author":"P Hoff","year":"2013","unstructured":"Hoff P, Buttgereit F, Burmester GR et al (2013) Osteoarthritis synovial fluid activates pro-inflammatory cytokines in primary human chondrocytes. Int Orthop 37(1):145\u2013151","journal-title":"Int Orthop"},{"issue":"2","key":"3983_CR194","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1136\/ard.62.2.108","volume":"62","author":"T Ushiyama","year":"2003","unstructured":"Ushiyama T, Chano T, Inoue K, Matsusue Y (2003) Cytokine production in the infrapatellar fat pad: another source of cytokines in knee synovial fluids. Ann Rheum Dis 62(2):108\u2013112","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"3983_CR195","doi-asserted-by":"publisher","first-page":"451","DOI":"10.3892\/ijmm.2014.1808","volume":"34","author":"L Jin","year":"2014","unstructured":"Jin L, Zhao J, Jing W et al (2014) Role of miR-146a in human chondrocyte apoptosis in response to mechanical pressure injury in vitro. Int J Mol Med 34(2):451\u2013463","journal-title":"Int J Mol Med"},{"issue":"30","key":"3983_CR196","doi-asserted-by":"publisher","first-page":"9424","DOI":"10.1073\/pnas.1505700112","volume":"112","author":"JH Kim","year":"2015","unstructured":"Kim JH, Lee G, Won Y et al (2015) Matrix cross-linking-mediated mechanotransduction promotes posttraumatic osteoarthritis. Proc Natl Acad Sci USA 112(30):9424\u20139429","journal-title":"Proc Natl Acad Sci USA"},{"issue":"24","key":"3983_CR197","doi-asserted-by":"publisher","first-page":"14998","DOI":"10.1074\/jbc.273.24.14998","volume":"273","author":"LC Bridgewater","year":"1998","unstructured":"Bridgewater LC, Lefebvre V, de Crombrugghe B (1998) Chondrocyte-specific enhancer elements in the Col11a2 gene resemble the Col2a1 tissue-specific enhancer. J Biol Chem 273(24):14998\u201315006","journal-title":"J Biol Chem"},{"issue":"3","key":"3983_CR198","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1002\/dvdy.22569","volume":"240","author":"MA Tryfonidou","year":"2011","unstructured":"Tryfonidou MA, Lunstrum GP, Hendriks K et al (2011) Novel type II collagen reporter mice: new tool for assessing collagen 2\u03b11 expression in vivo and in vitro. Dev Dyn 240(3):663\u2013673","journal-title":"Dev Dyn"},{"key":"3983_CR199","doi-asserted-by":"publisher","first-page":"76","DOI":"10.3389\/fbioe.2017.00076","volume":"5","author":"DE Anderson","year":"2017","unstructured":"Anderson DE, Johnstone B (2017) Dynamic mechanical compression of chondrocytes for tissue engineering: a critical review. Front Bioeng Biotechnol 5:76","journal-title":"Front Bioeng Biotechnol"},{"issue":"9","key":"3983_CR200","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1016\/j.joca.2014.06.032","volume":"22","author":"B Mohanraj","year":"2014","unstructured":"Mohanraj B, Meloni GR, Mauck RL, Dodge GR (2014) A high-throughput model of post-traumatic osteoarthritis using engineered cartilage tissue analogs. Osteoarthr Cartil 22(9):1282\u20131290","journal-title":"Osteoarthr Cartil"},{"issue":"4","key":"3983_CR201","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1016\/j.joca.2007.08.004","volume":"16","author":"CH Hsieh","year":"2008","unstructured":"Hsieh CH, Lin YH, Lin S, Tsai-Wu JJ, Herbert Wu CH, Jiang CC (2008) Surface ultrastructure and mechanical property of human chondrocyte revealed by atomic force microscopy. Osteoarthr Cartil 16(4):480\u2013488","journal-title":"Osteoarthr Cartil"},{"issue":"1","key":"3983_CR202","doi-asserted-by":"publisher","first-page":"0108021","DOI":"10.1115\/1.4029176","volume":"137","author":"R Oftadeh","year":"2015","unstructured":"Oftadeh R, Perez-Viloria M, Villa-Camacho JC, Vaziri A, Nazarian A (2015) Biomechanics and mechanobiology of trabecular bone: a review. J Biomech Eng 137(1):0108021\u201301080215","journal-title":"J Biomech Eng"},{"issue":"3","key":"3983_CR203","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.joca.2007.07.014","volume":"16","author":"RH Das","year":"2008","unstructured":"Das RH, Jahr H, Verhaar JA, van der Linden JC, van Osch GJ, Weinans H (2008) In vitro expansion affects the response of chondrocytes to mechanical stimulation. Osteoarthr Cartil 16(3):385\u2013391","journal-title":"Osteoarthr Cartil"},{"issue":"6","key":"3983_CR204","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/j.joca.2005.12.003","volume":"14","author":"EM Darling","year":"2006","unstructured":"Darling EM, Zauscher S, Guilak F (2006) Viscoelastic properties of zonal articular chondrocytes measured by atomic force microscopy. Osteoarthr Cartil 14(6):571\u2013579","journal-title":"Osteoarthr Cartil"},{"issue":"1","key":"3983_CR205","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/nbt.3419","volume":"34","author":"J Kang","year":"2016","unstructured":"Kang J, Hsu CH, Wu Q et al (2016) Improving drug discovery with high-content phenotypic screens by systematic selection of reporter cell lines. Nat Biotechnol 34(1):70\u201377","journal-title":"Nat Biotechnol"},{"issue":"5795","key":"3983_CR206","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1126\/science.1132939","volume":"313","author":"J Lamb","year":"2006","unstructured":"Lamb J, Crawford ED, Peck D et al (2006) The connectivity map: using gene-expression signatures to connect small molecules, genes, and disease. Science 313(5795):1929\u20131935","journal-title":"Science"},{"issue":"1","key":"3983_CR207","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/nbt.3367","volume":"34","author":"BA Kidd","year":"2016","unstructured":"Kidd BA, Wroblewska A, Boland MR et al (2016) Mapping the effects of drugs on the immune system. Nat Biotechnol 34(1):47\u201354","journal-title":"Nat Biotechnol"},{"issue":"6","key":"3983_CR208","doi-asserted-by":"publisher","first-page":"4895","DOI":"10.1002\/jcp.26298","volume":"233","author":"AM Brum","year":"2018","unstructured":"Brum AM, van de Peppel J, Nguyen L et al (2018) Using the Connectivity Map to discover compounds influencing human osteoblast differentiation. J Cell Physiol 233(6):4895\u20134906","journal-title":"J Cell Physiol"},{"key":"3983_CR209","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.jhealeco.2016.01.012","volume":"47","author":"JA DiMasi","year":"2016","unstructured":"DiMasi JA, Grabowski HG, Hansen RW (2016) Innovation in the pharmaceutical industry: new estimates of R&D costs. J Health Econ 47:20\u201333","journal-title":"J Health Econ"},{"issue":"10","key":"3983_CR210","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1038\/nrd.2017.146","volume":"16","author":"AM Davis","year":"2017","unstructured":"Davis AM, Plowright AT, Valeur E (2017) Directing evolution: the next revolution in drug discovery. Nat Rev Drug Discov 16(10):681\u2013698","journal-title":"Nat Rev Drug Discov"},{"issue":"10","key":"3983_CR211","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1038\/nrd.2018.116","volume":"17","author":"J Bostr\u00f6m","year":"2018","unstructured":"Bostr\u00f6m J, Brown DG, Young RJ, Keser\u00fc GM (2018) Expanding the medicinal chemistry synthetic toolbox. Nat Rev Drug Discov 17(10):709\u2013727","journal-title":"Nat Rev Drug Discov"},{"issue":"34","key":"3983_CR212","doi-asserted-by":"publisher","first-page":"8840","DOI":"10.1002\/anie.201310843","volume":"53","author":"PM Wright","year":"2014","unstructured":"Wright PM, Seiple IB, Myers AG (2014) The evolving role of chemical synthesis in antibacterial drug discovery. Angew Chem Int Ed Engl 53(34):8840\u20138869","journal-title":"Angew Chem Int Ed Engl"},{"issue":"12","key":"3983_CR213","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1080\/14712598.2016.1229774","volume":"16","author":"S Zheng","year":"2016","unstructured":"Zheng S, Hunter DJ, Xu J, Ding C (2016) Monoclonal antibodies for the treatment of osteoarthritis. Expert Opin Biol Ther 16(12):1529\u20131540","journal-title":"Expert Opin Biol Ther"},{"issue":"7","key":"3983_CR214","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1007\/s40266-015-0276-7","volume":"32","author":"N Arden","year":"2015","unstructured":"Arden N, Richette P, Cooper C et al (2015) Can we identify patients with high risk of osteoarthritis progression who will respond to treatment? A focus on biomarkers and frailty. Drugs Aging 32(7):525\u2013535","journal-title":"Drugs Aging"},{"issue":"9","key":"3983_CR215","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.1093\/rheumatology\/kev100","volume":"54","author":"JH Waarsing","year":"2015","unstructured":"Waarsing JH, Bierma-Zeinstra SM, Weinans H (2015) Distinct subtypes of knee osteoarthritis: data from the osteoarthritis initiative. Rheumatology (Oxford) 54(9):1650\u20131658","journal-title":"Rheumatology (Oxford)"}],"container-title":["Cellular and Molecular Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-021-03983-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00018-021-03983-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-021-03983-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T09:56:39Z","timestamp":1744192599000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00018-021-03983-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,16]]},"references-count":215,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["3983"],"URL":"https:\/\/doi.org\/10.1007\/s00018-021-03983-8","relation":{},"ISSN":["1420-682X","1420-9071"],"issn-type":[{"value":"1420-682X","type":"print"},{"value":"1420-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,16]]},"assertion":[{"value":"24 May 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 September 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 November 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Consent for publication was obtained from all participants.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no conflicts of interest to this work.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}