{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:40:54Z","timestamp":1790188854096,"version":"4.1.0"},"reference-count":81,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T00:00:00Z","timestamp":1642550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T00:00:00Z","timestamp":1642550400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81970884"],"award-info":[{"award-number":["81970884"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81900941"],"award-info":[{"award-number":["81900941"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81900944"],"award-info":[{"award-number":["81900944"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81622013"],"award-info":[{"award-number":["81622013"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81970882"],"award-info":[{"award-number":["81970882"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81570919"],"award-info":[{"award-number":["81570919"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81870721"],"award-info":[{"award-number":["81870721"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81771019"],"award-info":[{"award-number":["81771019"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81700913"],"award-info":[{"award-number":["81700913"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81670928"],"award-info":[{"award-number":["81670928"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81570921"],"award-info":[{"award-number":["81570921"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the National Key R&D Program of China","award":["2017YFA0103903"],"award-info":[{"award-number":["2017YFA0103903"]}]},{"name":"the Strategic Priority Research Program of the Chinese Academy of Science","award":["XDA16010303"],"award-info":[{"award-number":["XDA16010303"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell. Mol. Life Sci."],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The Hippo\/Yes-associated protein (YAP) signaling pathway has been shown to be able to maintain organ size and homeostasis by regulating cell proliferation, differentiation, and apoptosis. The abuse of aminoglycosides is one of the main causes of sensorineural hearing loss (SSNHL). However, the role of the Hippo\/YAP signaling pathway in cochlear hair cell (HC) damage protection in the auditory field is still unclear. In this study, we used the YAP agonist XMU-MP-1 (XMU) and the inhibitor Verteporfin (VP) to regulate the Hippo\/YAP signaling pathway in vitro. We showed that YAP overexpression reduced neomycin-induced HC loss, while downregulated YAP expression increased HC vulnerability after neomycin exposure in vitro. We next found that activation of YAP expression inhibited C-Abl-mediated cell apoptosis, which led to reduced HC loss. Many previous studies have reported that the level of reactive oxygen species (ROS) is significantly increased in cochlear HCs after neomycin exposure. In our study, we also found that YAP overexpression significantly decreased ROS accumulation, while downregulation of YAP expression increased ROS accumulation. In summary, our results demonstrate that the Hippo\/YAP signaling pathway plays an important role in reducing HC injury and maintaining auditory function after aminoglycoside exposure. YAP overexpression could protect against neomycin-induced HC loss by inhibiting C-Abl-mediated cell apoptosis and decreasing ROS accumulation, suggesting that YAP could be a novel therapeutic target for aminoglycosides-induced sensorineural hearing loss in the clinic.<\/jats:p>","DOI":"10.1007\/s00018-021-04029-9","type":"journal-article","created":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T16:03:18Z","timestamp":1642608198000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Hippo\/YAP signaling pathway protects against neomycin-induced hair cell damage in the mouse cochlea"],"prefix":"10.1007","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5985-2430","authenticated-orcid":false,"given":"Maohua","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhua","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiying","family":"Qiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenjie","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youjun","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renjie","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,19]]},"reference":[{"key":"4029_CR1","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.pharmthera.2019.05.003","volume":"200","author":"Y Ma","year":"2019","unstructured":"Ma Y, Wise AK, Shepherd RK et al (2019) New molecular therapies for the treatment of hearing loss. Pharmacol Ther 200:190\u2013209. https:\/\/doi.org\/10.1016\/j.pharmthera.2019.05.003","journal-title":"Pharmacol Ther"},{"key":"4029_CR2","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1111\/j.1399-0004.2006.00613.x","volume":"69","author":"MB Petersen","year":"2006","unstructured":"Petersen MB, Willems PJ (2006) Non-syndromic, autosomal-recessive deafness. Clin Genet 69:371\u2013392. https:\/\/doi.org\/10.1111\/j.1399-0004.2006.00613.x","journal-title":"Clin Genet"},{"key":"4029_CR3","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.1002\/ar.22578","volume":"295","author":"J Schacht","year":"2012","unstructured":"Schacht J, Talaska AE, Rybak LP (2012) Cisplatin and aminoglycoside antibiotics: hearing loss and its prevention. Anat Rec 295:1837\u20131850. https:\/\/doi.org\/10.1002\/ar.22578","journal-title":"Anat Rec"},{"key":"4029_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2019.111191","volume":"185","author":"KN Prasad","year":"2020","unstructured":"Prasad KN, Bondy SC (2020) Increased oxidative stress, inflammation, and glutamate: Potential preventive and therapeutic targets for hearing disorders. Mech Ageing Dev 185:111191. https:\/\/doi.org\/10.1016\/j.mad.2019.111191","journal-title":"Mech Ageing Dev"},{"key":"4029_CR5","doi-asserted-by":"publisher","first-page":"2465","DOI":"10.1056\/NEJMra1616601","volume":"377","author":"LL Cunningham","year":"2017","unstructured":"Cunningham LL, Tucci DL (2017) Hearing loss in adults. N Engl J Med 377:2465\u20132473. https:\/\/doi.org\/10.1056\/NEJMra1616601","journal-title":"N Engl J Med"},{"key":"4029_CR6","first-page":"601","volume":"15","author":"G Cianfrone","year":"2011","unstructured":"Cianfrone G, Pentangelo D, Cianfrone F et al (2011) Pharmacological drugs inducing ototoxicity, vestibular symptoms and tinnitus: a reasoned and updated guide. Eur Rev Med Pharmacol Sci 15:601\u2013636","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"4029_CR7","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1002\/cpt.603","volume":"101","author":"C Lanvers-Kaminsky","year":"2017","unstructured":"Lanvers-Kaminsky C, Zehnhoff-Dinnesen AA, Parfitt R et al (2017) Drug-induced ototoxicity: Mechanisms, Pharmacogenetics, and protective strategies. Clin Pharmacol Ther 101:491\u2013500. https:\/\/doi.org\/10.1002\/cpt.603","journal-title":"Clin Pharmacol Ther"},{"key":"4029_CR8","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1172\/JCI77424","volume":"125","author":"ME Huth","year":"2015","unstructured":"Huth ME, Han KH, Sotoudeh K et al (2015) Designer aminoglycosides prevent cochlear hair cell loss and hearing loss. J Clin Invest 125:583\u2013592. https:\/\/doi.org\/10.1172\/JCI77424","journal-title":"J Clin Invest"},{"key":"4029_CR9","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1101\/gad.9.5.534","volume":"9","author":"RW Justice","year":"1995","unstructured":"Justice RW, Zilian O, Woods DF et al (1995) The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation. Genes Dev 9:534\u2013546. https:\/\/doi.org\/10.1101\/gad.9.5.534","journal-title":"Genes Dev"},{"key":"4029_CR10","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/s0092-8674(02)00824-3","volume":"110","author":"N Tapon","year":"2002","unstructured":"Tapon N, Harvey KF, Bell DW et al (2002) Salvador promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines. Cell 110:467\u2013478. https:\/\/doi.org\/10.1016\/s0092-8674(02)00824-3","journal-title":"Cell"},{"key":"4029_CR11","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/s0092-8674(03)00557-9","volume":"114","author":"KF Harvey","year":"2003","unstructured":"Harvey KF, Pfleger CM, Hariharan IK (2003) The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis. Cell 114:457\u2013467. https:\/\/doi.org\/10.1016\/s0092-8674(03)00557-9","journal-title":"Cell"},{"key":"4029_CR12","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.cell.2004.12.036","volume":"120","author":"ZC Lai","year":"2005","unstructured":"Lai ZC, Wei X, Shimizu T et al (2005) Control of cell proliferation and apoptosis by mob as tumor suppressor, mats. Cell 120:675\u2013685. https:\/\/doi.org\/10.1016\/j.cell.2004.12.036","journal-title":"Cell"},{"key":"4029_CR13","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/j.cell.2015.10.044","volume":"163","author":"FX Yu","year":"2015","unstructured":"Yu FX, Zhao B, Guan KL (2015) Hippo pathway in organ size control, tissue homeostasis, and cancer. Cell 163:811\u2013828. https:\/\/doi.org\/10.1016\/j.cell.2015.10.044","journal-title":"Cell"},{"key":"4029_CR14","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.cell.2005.06.007","volume":"122","author":"J Huang","year":"2005","unstructured":"Huang J, Wu S, Barrera J et al (2005) The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP. Cell 122:421\u2013434. https:\/\/doi.org\/10.1016\/j.cell.2005.06.007","journal-title":"Cell"},{"key":"4029_CR15","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1101\/gad.1909210","volume":"24","author":"B Zhao","year":"2010","unstructured":"Zhao B, Li L, Lei Q et al (2010) The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version. Genes Dev 24:862\u2013874. https:\/\/doi.org\/10.1101\/gad.1909210","journal-title":"Genes Dev"},{"key":"4029_CR16","doi-asserted-by":"publisher","first-page":"2747","DOI":"10.1101\/gad.1602907","volume":"21","author":"B Zhao","year":"2007","unstructured":"Zhao B, Wei X, Li W et al (2007) Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev 21:2747\u20132761. https:\/\/doi.org\/10.1101\/gad.1602907","journal-title":"Genes Dev"},{"key":"4029_CR17","doi-asserted-by":"publisher","first-page":"642","DOI":"10.15252\/embr.201438638","volume":"15","author":"JS Mo","year":"2014","unstructured":"Mo JS, Park HW, Guan KL (2014) The Hippo signaling pathway in stem cell biology and cancer. EMBO Rep 15:642\u2013656. https:\/\/doi.org\/10.15252\/embr.201438638","journal-title":"EMBO Rep"},{"key":"4029_CR18","doi-asserted-by":"publisher","first-page":"1962","DOI":"10.1101\/gad.1664408","volume":"22","author":"B Zhao","year":"2008","unstructured":"Zhao B, Ye X, Yu J et al (2008) TEAD mediates YAP-dependent gene induction and growth control. Genes Dev 22:1962\u20131971. https:\/\/doi.org\/10.1101\/gad.1664408","journal-title":"Genes Dev"},{"key":"4029_CR19","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.cell.2006.01.005","volume":"124","author":"BA Edgar","year":"2006","unstructured":"Edgar BA (2006) From cell structure to transcription: hippo forges a new path. Cell 124:267\u2013273. https:\/\/doi.org\/10.1016\/j.cell.2006.01.005","journal-title":"Cell"},{"key":"4029_CR20","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1038\/nrc2070","volume":"7","author":"K Harvey","year":"2007","unstructured":"Harvey K, Tapon N (2007) The Salvador-Warts-Hippo pathway\u2014an emerging tumour-suppressor network. Nat Rev Cancer 7:182\u2013191. https:\/\/doi.org\/10.1038\/nrc2070","journal-title":"Nat Rev Cancer"},{"key":"4029_CR21","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.devcel.2010.09.011","volume":"19","author":"D Pan","year":"2010","unstructured":"Pan D (2010) The hippo signaling pathway in development and cancer. Dev Cell 19:491\u2013505. https:\/\/doi.org\/10.1016\/j.devcel.2010.09.011","journal-title":"Dev Cell"},{"key":"4029_CR22","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1242\/dev.045500","volume":"138","author":"G Halder","year":"2011","unstructured":"Halder G, Johnson RL (2011) Hippo signaling: growth control and beyond. Development 138:9\u201322. https:\/\/doi.org\/10.1242\/dev.045500","journal-title":"Development"},{"key":"4029_CR23","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.devcel.2019.06.003","volume":"50","author":"Y Zheng","year":"2019","unstructured":"Zheng Y, Pan D (2019) The hippo signaling pathway in development and disease. Dev Cell 50:264\u2013282. https:\/\/doi.org\/10.1016\/j.devcel.2019.06.003","journal-title":"Dev Cell"},{"key":"4029_CR24","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/nature14228","volume":"519","author":"K Taniguchi","year":"2015","unstructured":"Taniguchi K, Wu LW, Grivennikov SI et al (2015) A gp130-Src-YAP module links inflammation to epithelial regeneration. Nature 519:57\u201362. https:\/\/doi.org\/10.1038\/nature14228","journal-title":"Nature"},{"key":"4029_CR25","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/j.tips.2013.08.006","volume":"34","author":"HW Park","year":"2013","unstructured":"Park HW, Guan KL (2013) Regulation of the Hippo pathway and implications for anticancer drug development. Trends Pharmacol Sci 34:581\u2013589. https:\/\/doi.org\/10.1016\/j.tips.2013.08.006","journal-title":"Trends Pharmacol Sci"},{"key":"4029_CR26","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1038\/cr.2014.10","volume":"24","author":"W Zhang","year":"2014","unstructured":"Zhang W, Gao Y, Li P et al (2014) VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex. Cell Res 24:331\u2013343. https:\/\/doi.org\/10.1038\/cr.2014.10","journal-title":"Cell Res"},{"key":"4029_CR27","doi-asserted-by":"publisher","first-page":"8292173","DOI":"10.1155\/2020\/8292173","volume":"2020","author":"K Xu","year":"2020","unstructured":"Xu K, Zhao H, Qiu X et al (2020) VGLL4 protects against oxidized-LDL-induced endothelial cell dysfunction and inflammation by activating hippo-YAP\/TEAD1 signaling pathway. Mediators Inflamm 2020:8292173. https:\/\/doi.org\/10.1155\/2020\/8292173","journal-title":"Mediators Inflamm"},{"key":"4029_CR28","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.2174\/0929867323666160316125048","volume":"23","author":"F Gibault","year":"2016","unstructured":"Gibault F, Corvaisier M, Bailly F et al (2016) Non-photoinduced biological properties of verteporfin. Curr Med Chem 23:1171\u20131184. https:\/\/doi.org\/10.2174\/0929867323666160316125048","journal-title":"Curr Med Chem"},{"key":"4029_CR29","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/s41580-018-0086-y","volume":"20","author":"IM Moya","year":"2019","unstructured":"Moya IM, Halder G (2019) Hippo-YAP\/TAZ signalling in organ regeneration and regenerative medicine. Nat Rev Mol Cell Biol 20:211\u2013226. https:\/\/doi.org\/10.1038\/s41580-018-0086-y","journal-title":"Nat Rev Mol Cell Biol"},{"key":"4029_CR30","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.ydbio.2016.09.001","volume":"419","author":"JY Kim","year":"2016","unstructured":"Kim JY, Park R, Lee JH et al (2016) Yap is essential for retinal progenitor cell cycle progression and RPE cell fate acquisition in the developing mouse eye. Dev Biol 419:336\u2013347. https:\/\/doi.org\/10.1016\/j.ydbio.2016.09.001","journal-title":"Dev Biol"},{"key":"4029_CR31","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1002\/hep.25769","volume":"56","author":"H Bai","year":"2012","unstructured":"Bai H, Zhang N, Xu Y et al (2012) Yes-associated protein regulates the hepatic response after bile duct ligation. Hepatology 56:1097\u20131107. https:\/\/doi.org\/10.1002\/hep.25769","journal-title":"Hepatology"},{"key":"4029_CR32","doi-asserted-by":"publisher","first-page":"10329","DOI":"10.1038\/ncomms10329","volume":"7","author":"R Park","year":"2016","unstructured":"Park R, Moon UY, Park JY et al (2016) Yap is required for ependymal integrity and is suppressed in LPA-induced hydrocephalus. Nat Commun 7:10329. https:\/\/doi.org\/10.1038\/ncomms10329","journal-title":"Nat Commun"},{"key":"4029_CR33","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1038\/jid.2013.339","volume":"134","author":"MJ Lee","year":"2014","unstructured":"Lee MJ, Byun MR, Furutani-Seiki M et al (2014) YAP and TAZ regulate skin wound healing. J Invest Dermatol 134:518\u2013525. https:\/\/doi.org\/10.1038\/jid.2013.339","journal-title":"J Invest Dermatol"},{"key":"4029_CR34","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1161\/CIRCRESAHA.116.308586","volume":"119","author":"T Matsuda","year":"2016","unstructured":"Matsuda T, Zhai P, Sciarretta S et al (2016) NF2 activates hippo signaling and promotes ischemia\/reperfusion injury in the heart. Circ Res 119:596\u2013606. https:\/\/doi.org\/10.1161\/CIRCRESAHA.116.308586","journal-title":"Circ Res"},{"key":"4029_CR35","doi-asserted-by":"publisher","first-page":"17057","DOI":"10.1074\/jbc.C113.457390","volume":"288","author":"KN Campbell","year":"2013","unstructured":"Campbell KN, Wong JS, Gupta R et al (2013) Yes-associated protein (YAP) promotes cell survival by inhibiting proapoptotic dendrin signaling. J Biol Chem 288:17057\u201317062. https:\/\/doi.org\/10.1074\/jbc.C113.457390","journal-title":"J Biol Chem"},{"key":"4029_CR36","doi-asserted-by":"publisher","first-page":"2996","DOI":"10.1038\/srep02996","volume":"3","author":"Y Chen","year":"2013","unstructured":"Chen Y, Yu H, Zhang Y et al (2013) Cotransfection of Pax2 and Math1 promote in situ cochlear hair cell regeneration after neomycin insult. Sci Rep 3:2996. https:\/\/doi.org\/10.1038\/srep02996","journal-title":"Sci Rep"},{"key":"4029_CR37","doi-asserted-by":"publisher","DOI":"10.3791\/1685","author":"M Parker","year":"2010","unstructured":"Parker M, Brugeaud A, Edge AS (2010) Primary culture and plasmid electroporation of the murine organ of Corti. J Vis Exp. https:\/\/doi.org\/10.3791\/1685","journal-title":"J Vis Exp"},{"key":"4029_CR38","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1523\/JNEUROSCI.22-04-01218.2002","volume":"22","author":"JI Matsui","year":"2002","unstructured":"Matsui JI, Ogilvie JM, Warchol ME (2002) Inhibition of caspases prevents ototoxic and ongoing hair cell death. J Neurosci 22:1218\u20131227","journal-title":"J Neurosci"},{"key":"4029_CR39","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1007\/s12035-014-8841-3","volume":"52","author":"Y He","year":"2015","unstructured":"He Y, Yu H, Cai C et al (2015) Inhibition of H3K4me2 demethylation protects auditory hair cells from neomycin-induced apoptosis. Mol Neurobiol 52:196\u2013205. https:\/\/doi.org\/10.1007\/s12035-014-8841-3","journal-title":"Mol Neurobiol"},{"key":"4029_CR40","doi-asserted-by":"publisher","first-page":"248","DOI":"10.3389\/fncel.2014.00248","volume":"8","author":"S Sun","year":"2014","unstructured":"Sun S, Sun M, Zhang Y et al (2014) In vivo overexpression of X-linked inhibitor of apoptosis protein protects against neomycin-induced hair cell loss in the apical turn of the cochlea during the ototoxic-sensitive period. Front Cell Neurosci 8:248. https:\/\/doi.org\/10.3389\/fncel.2014.00248","journal-title":"Front Cell Neurosci"},{"key":"4029_CR41","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1007\/s12035-014-8712-y","volume":"51","author":"S Sun","year":"2015","unstructured":"Sun S, Yu H, Yu H et al (2015) Inhibition of the activation and recruitment of microglia-like cells protects against neomycin-induced ototoxicity. Mol Neurobiol 51:252\u2013267. https:\/\/doi.org\/10.1007\/s12035-014-8712-y","journal-title":"Mol Neurobiol"},{"key":"4029_CR42","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.neuroscience.2009.02.085","volume":"161","author":"YH Choung","year":"2009","unstructured":"Choung YH, Taura A, Pak K et al (2009) Generation of highly-reactive oxygen species is closely related to hair cell damage in rat organ of Corti treated with gentamicin. Neuroscience 161:214\u2013226. https:\/\/doi.org\/10.1016\/j.neuroscience.2009.02.085","journal-title":"Neuroscience"},{"key":"4029_CR43","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.cell.2005.02.001","volume":"120","author":"RS Balaban","year":"2005","unstructured":"Balaban RS, Nemoto S, Finkel T (2005) Mitochondria, oxidants, and aging. Cell 120:483\u2013495. https:\/\/doi.org\/10.1016\/j.cell.2005.02.001","journal-title":"Cell"},{"key":"4029_CR44","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/s0736-5748(99)00094-5","volume":"18","author":"T Huang","year":"2000","unstructured":"Huang T, Cheng AG, Stupak H et al (2000) Oxidative stress-induced apoptosis of cochlear sensory cells: otoprotective strategies. Int J Dev Neurosci 18:259\u2013270. https:\/\/doi.org\/10.1016\/s0736-5748(99)00094-5","journal-title":"Int J Dev Neurosci"},{"key":"4029_CR45","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.abb.2016.08.021","volume":"617","author":"B Kalyanaraman","year":"2017","unstructured":"Kalyanaraman B, Hardy M, Podsiadly R et al (2017) Recent developments in detection of superoxide radical anion and hydrogen peroxide: opportunities, challenges, and implications in redox signaling. Arch Biochem Biophys 617:38\u201347. https:\/\/doi.org\/10.1016\/j.abb.2016.08.021","journal-title":"Arch Biochem Biophys"},{"key":"4029_CR46","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/nature08040","volume":"459","author":"J Liu","year":"2009","unstructured":"Liu J, Cao L, Chen J et al (2009) Bmi1 regulates mitochondrial function and the DNA damage response pathway. Nature 459:387\u2013392. https:\/\/doi.org\/10.1038\/nature08040","journal-title":"Nature"},{"key":"4029_CR47","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1038\/nm.1868","volume":"14","author":"H Du","year":"2008","unstructured":"Du H, Guo L, Fang F et al (2008) Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer\u2019s disease. Nat Med 14:1097\u20131105. https:\/\/doi.org\/10.1038\/nm.1868","journal-title":"Nat Med"},{"key":"4029_CR48","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1038\/cdd.2009.96","volume":"16","author":"S Yousefi","year":"2009","unstructured":"Yousefi S, Mihalache C, Kozlowski E et al (2009) Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps. Cell Death Differ 16:1438\u20131444. https:\/\/doi.org\/10.1038\/cdd.2009.96","journal-title":"Cell Death Differ"},{"key":"4029_CR49","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1038\/cdd.2013.83","volume":"20","author":"N Reuven","year":"2013","unstructured":"Reuven N, Adler J, Meltser V et al (2013) The Hippo pathway kinase Lats2 prevents DNA damage-induced apoptosis through inhibition of the tyrosine kinase c-Abl. Cell Death Differ 20:1330\u20131340. https:\/\/doi.org\/10.1038\/cdd.2013.83","journal-title":"Cell Death Differ"},{"key":"4029_CR50","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s13008-016-0013-6","volume":"11","author":"M He","year":"2016","unstructured":"He M, Zhou Z, Shah AA et al (2016) New insights into posttranslational modifications of Hippo pathway in carcinogenesis and therapeutics. Cell Div 11:4. https:\/\/doi.org\/10.1186\/s13008-016-0013-6","journal-title":"Cell Div"},{"key":"4029_CR51","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1038\/cdd.2014.182","volume":"22","author":"R Keshet","year":"2015","unstructured":"Keshet R, Adler J, Ricardo Lax I et al (2015) c-Abl antagonizes the YAP oncogenic function. Cell Death Differ 22:935\u2013945. https:\/\/doi.org\/10.1038\/cdd.2014.182","journal-title":"Cell Death Differ"},{"key":"4029_CR52","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.molcel.2007.12.022","volume":"29","author":"D Levy","year":"2008","unstructured":"Levy D, Adamovich Y, Reuven N et al (2008) Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage. Mol Cell 29:350\u2013361. https:\/\/doi.org\/10.1016\/j.molcel.2007.12.022","journal-title":"Mol Cell"},{"key":"4029_CR53","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1038\/21690","volume":"399","author":"JG Gong","year":"1999","unstructured":"Gong JG, Costanzo A, Yang HQ et al (1999) The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage. Nature 399:806\u2013809. https:\/\/doi.org\/10.1038\/21690","journal-title":"Nature"},{"key":"4029_CR54","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1038\/21704","volume":"399","author":"ZM Yuan","year":"1999","unstructured":"Yuan ZM, Shioya H, Ishiko T et al (1999) p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage. Nature 399:814\u2013817. https:\/\/doi.org\/10.1038\/21704","journal-title":"Nature"},{"key":"4029_CR55","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1038\/ncb2303","volume":"13","author":"B Zhao","year":"2011","unstructured":"Zhao B, Tumaneng K, Guan KL (2011) The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal. Nat Cell Biol 13:877\u2013883. https:\/\/doi.org\/10.1038\/ncb2303","journal-title":"Nat Cell Biol"},{"key":"4029_CR56","doi-asserted-by":"publisher","first-page":"389","DOI":"10.3389\/fphys.2020.00389","volume":"11","author":"X Chen","year":"2020","unstructured":"Chen X, Li Y, Luo J et al (2020) Molecular mechanism of hippo-YAP1\/TAZ pathway in heart development, disease, and regeneration. Front Physiol 11:389. https:\/\/doi.org\/10.3389\/fphys.2020.00389","journal-title":"Front Physiol"},{"key":"4029_CR57","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1038\/s41569-018-0063-3","volume":"15","author":"J Wang","year":"2018","unstructured":"Wang J, Liu S, Heallen T et al (2018) The Hippo pathway in the heart: pivotal roles in development, disease, and regeneration. Nat Rev Cardiol 15:672\u2013684. https:\/\/doi.org\/10.1038\/s41569-018-0063-3","journal-title":"Nat Rev Cardiol"},{"key":"4029_CR58","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1073\/pnas.0911409107","volume":"107","author":"H Song","year":"2010","unstructured":"Song H, Mak KK, Topol L et al (2010) Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression. Proc Natl Acad Sci U S A 107:1431\u20131436. https:\/\/doi.org\/10.1073\/pnas.0911409107","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4029_CR59","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1016\/j.cell.2007.07.019","volume":"130","author":"J Dong","year":"2007","unstructured":"Dong J, Feldmann G, Huang J et al (2007) Elucidation of a universal size-control mechanism in Drosophila and mammals. Cell 130:1120\u20131133. https:\/\/doi.org\/10.1016\/j.cell.2007.07.019","journal-title":"Cell"},{"key":"4029_CR60","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1161\/CIRCRESAHA.116.303311","volume":"116","author":"Q Zhou","year":"2015","unstructured":"Zhou Q, Li L, Zhao B et al (2015) The hippo pathway in heart development, regeneration, and diseases. Circ Res 116:1431\u20131447. https:\/\/doi.org\/10.1161\/CIRCRESAHA.116.303311","journal-title":"Circ Res"},{"key":"4029_CR61","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024288","volume":"6","author":"P Wang","year":"2011","unstructured":"Wang P, Bai Y, Song B et al (2011) PP1A-mediated dephosphorylation positively regulates YAP2 activity. PLoS ONE 6:e24288. https:\/\/doi.org\/10.1371\/journal.pone.0024288","journal-title":"PLoS ONE"},{"issue":"35\u201349","key":"4029_CR62","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2017.11.001","volume":"22","author":"S Yui","year":"2018","unstructured":"Yui S, Azzolin L, Maimets M et al (2018) YAP\/TAZ-dependent reprogramming of colonic epithelium links ECM remodeling to tissue regeneration. Cell Stem Cell 22(35\u201349):e37. https:\/\/doi.org\/10.1016\/j.stem.2017.11.001","journal-title":"Cell Stem Cell"},{"key":"4029_CR63","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2011.76","volume":"2","author":"SP Francis","year":"2011","unstructured":"Francis SP, Kramarenko II, Brandon CS et al (2011) Celastrol inhibits aminoglycoside-induced ototoxicity via heat shock protein 32. Cell Death Dis 2:e195. https:\/\/doi.org\/10.1038\/cddis.2011.76","journal-title":"Cell Death Dis"},{"key":"4029_CR64","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1172\/JCI85052","volume":"127","author":"DW Hailey","year":"2017","unstructured":"Hailey DW, Esterberg R, Linbo TH et al (2017) Fluorescent aminoglycosides reveal intracellular trafficking routes in mechanosensory hair cells. J Clin Invest 127:472\u2013486. https:\/\/doi.org\/10.1172\/JCI85052","journal-title":"J Clin Invest"},{"key":"4029_CR65","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/937861","volume":"2011","author":"ME Huth","year":"2011","unstructured":"Huth ME, Ricci AJ, Cheng AG (2011) Mechanisms of aminoglycoside ototoxicity and targets of hair cell protection. Int J Otolaryngol 2011:937861. https:\/\/doi.org\/10.1155\/2011\/937861","journal-title":"Int J Otolaryngol"},{"key":"4029_CR66","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/978-981-13-6123-4_2","volume":"1130","author":"J Guo","year":"2019","unstructured":"Guo J, Chai R, Li H et al (2019) Protection of hair cells from ototoxic drug-induced hearing loss. Adv Exp Med Biol 1130:17\u201336. https:\/\/doi.org\/10.1007\/978-981-13-6123-4_2","journal-title":"Adv Exp Med Biol"},{"key":"4029_CR67","doi-asserted-by":"publisher","first-page":"2140","DOI":"10.1038\/s41598-020-77775-8","volume":"11","author":"V Borse","year":"2021","unstructured":"Borse V, Barton M, Arndt H et al (2021) Dynamic patterns of YAP1 expression and cellular localization in the developing and injured utricle. Sci Rep 11:2140. https:\/\/doi.org\/10.1038\/s41598-020-77775-8","journal-title":"Sci Rep"},{"key":"4029_CR68","doi-asserted-by":"publisher","first-page":"3915","DOI":"10.1523\/JNEUROSCI.0306-20.2020","volume":"40","author":"MA Rudolf","year":"2020","unstructured":"Rudolf MA, Andreeva A, Kozlowski MM et al (2020) YAP mediates hair cell regeneration in balance organs of chickens, but LATS kinases suppress its activity in Mice. J Neurosci 40:3915\u20133932. https:\/\/doi.org\/10.1523\/JNEUROSCI.0306-20.2020","journal-title":"J Neurosci"},{"key":"4029_CR69","doi-asserted-by":"publisher","first-page":"13552","DOI":"10.1073\/pnas.2000175117","volume":"117","author":"K Gnedeva","year":"2020","unstructured":"Gnedeva K, Wang X, McGovern MM et al (2020) Organ of Corti size is governed by Yap\/Tead-mediated progenitor self-renewal. Proc Natl Acad Sci U S A 117:13552\u201313561. https:\/\/doi.org\/10.1073\/pnas.2000175117","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4029_CR70","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1038\/nrm.2017.87","volume":"18","author":"T Panciera","year":"2017","unstructured":"Panciera T, Azzolin L, Cordenonsi M et al (2017) Mechanobiology of YAP and TAZ in physiology and disease. Nat Rev Mol Cell Biol 18:758\u2013770. https:\/\/doi.org\/10.1038\/nrm.2017.87","journal-title":"Nat Rev Mol Cell Biol"},{"key":"4029_CR71","doi-asserted-by":"publisher","first-page":"352ra108","DOI":"10.1126\/scitranslmed.aaf2304","volume":"8","author":"F Fan","year":"2016","unstructured":"Fan F, He Z, Kong LL et al (2016) Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration. Sci Transl Med 8:352ra108. https:\/\/doi.org\/10.1126\/scitranslmed.aaf2304","journal-title":"Sci Transl Med"},{"key":"4029_CR72","doi-asserted-by":"publisher","first-page":"3956","DOI":"10.1111\/bph.14795","volume":"176","author":"E Triastuti","year":"2019","unstructured":"Triastuti E, Nugroho AB, Zi M et al (2019) Pharmacological inhibition of Hippo pathway, with the novel kinase inhibitor XMU-MP-1, protects the heart against adverse effects during pressure overload. Br J Pharmacol 176:3956\u20133971. https:\/\/doi.org\/10.1111\/bph.14795","journal-title":"Br J Pharmacol"},{"key":"4029_CR73","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1038\/eye.2015.251","volume":"30","author":"DK Newman","year":"2016","unstructured":"Newman DK (2016) Photodynamic therapy: current role in the treatment of chorioretinal conditions. Eye (Lond) 30:202\u2013210. https:\/\/doi.org\/10.1038\/eye.2015.251","journal-title":"Eye (Lond)"},{"key":"4029_CR74","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1101\/gad.192856.112","volume":"26","author":"Y Liu-Chittenden","year":"2012","unstructured":"Liu-Chittenden Y, Huang B, Shim JS et al (2012) Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP. Genes Dev 26:1300\u20131305. https:\/\/doi.org\/10.1101\/gad.192856.112","journal-title":"Genes Dev"},{"key":"4029_CR75","doi-asserted-by":"publisher","first-page":"96","DOI":"10.3389\/fncel.2015.00096","volume":"9","author":"CT Dinh","year":"2015","unstructured":"Dinh CT, Goncalves S, Bas E et al (2015) Molecular regulation of auditory hair cell death and approaches to protect sensory receptor cells and\/or stimulate repair following acoustic trauma. Front Cell Neurosci 9:96. https:\/\/doi.org\/10.3389\/fncel.2015.00096","journal-title":"Front Cell Neurosci"},{"key":"4029_CR76","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1039\/c1ib00034a","volume":"3","author":"T Karasawa","year":"2011","unstructured":"Karasawa T, Steyger PS (2011) Intracellular mechanisms of aminoglycoside-induced cytotoxicity. Integr Biol 3:879\u2013886. https:\/\/doi.org\/10.1039\/c1ib00034a","journal-title":"Integr Biol"},{"key":"4029_CR77","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1111\/j.1749-6632.2010.05634.x","volume":"1201","author":"TI Peng","year":"2010","unstructured":"Peng TI, Jou MJ (2010) Oxidative stress caused by mitochondrial calcium overload. Ann N Y Acad Sci 1201:183\u2013188. https:\/\/doi.org\/10.1111\/j.1749-6632.2010.05634.x","journal-title":"Ann N Y Acad Sci"},{"key":"4029_CR78","doi-asserted-by":"publisher","first-page":"58","DOI":"10.3389\/fnagi.2015.00058","volume":"7","author":"AC Wong","year":"2015","unstructured":"Wong AC, Ryan AF (2015) Mechanisms of sensorineural cell damage, death and survival in the cochlea. Front Aging Neurosci 7:58. https:\/\/doi.org\/10.3389\/fnagi.2015.00058","journal-title":"Front Aging Neurosci"},{"key":"4029_CR79","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.heares.2011.05.008","volume":"281","author":"J Xie","year":"2011","unstructured":"Xie J, Talaska AE, Schacht J (2011) New developments in aminoglycoside therapy and ototoxicity. Hear Res 281:28\u201337. https:\/\/doi.org\/10.1016\/j.heares.2011.05.008","journal-title":"Hear Res"},{"key":"4029_CR80","doi-asserted-by":"publisher","first-page":"15164","DOI":"10.1074\/jbc.M010484200","volume":"276","author":"S Strano","year":"2001","unstructured":"Strano S, Munarriz E, Rossi M et al (2001) Physical interaction with Yes-associated protein enhances p73 transcriptional activity. J Biol Chem 276:15164\u201315173. https:\/\/doi.org\/10.1074\/jbc.M010484200","journal-title":"J Biol Chem"},{"key":"4029_CR81","doi-asserted-by":"publisher","first-page":"27462","DOI":"10.1074\/jbc.M803941200","volume":"283","author":"D Levy","year":"2008","unstructured":"Levy D, Reuven N, Shaul Y (2008) A regulatory circuit controlling Itch-mediated p73 degradation by Runx. J Biol Chem 283:27462\u201327468. https:\/\/doi.org\/10.1074\/jbc.M803941200","journal-title":"J Biol Chem"}],"container-title":["Cellular and Molecular Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-021-04029-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00018-021-04029-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-021-04029-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T20:05:07Z","timestamp":1647374707000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00018-021-04029-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,19]]},"references-count":81,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["4029"],"URL":"https:\/\/doi.org\/10.1007\/s00018-021-04029-9","relation":{},"ISSN":["1420-682X","1420-9071"],"issn-type":[{"value":"1420-682X","type":"print"},{"value":"1420-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,19]]},"assertion":[{"value":"24 August 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 October 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 November 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 January 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All authors consent the publication of the manuscript in CMLS.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"79"}}