{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:15:18Z","timestamp":1791443718970,"version":"4.3.3"},"reference-count":109,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T00:00:00Z","timestamp":1640131200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T00:00:00Z","timestamp":1640131200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DA042348"],"award-info":[{"award-number":["DA042348"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DA053643"],"award-info":[{"award-number":["DA053643"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DA050169"],"award-info":[{"award-number":["DA050169"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell. Mol. Life Sci."],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1007\/s00018-021-04068-2","type":"journal-article","created":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T09:06:12Z","timestamp":1640163972000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["HIV-infection and cocaine use regulate semen extracellular vesicles proteome and miRNAome in a manner that mediates strategic monocyte haptotaxis governed by miR-128 network"],"prefix":"10.1007","volume":"79","author":[{"given":"Hussein","family":"Kaddour","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Kopcho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Lyu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Shouman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Paromov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddharth","family":"Pratap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandravanu","family":"Dash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun-Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Martinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"McKay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Epeldegui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph B.","family":"Margolick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack T.","family":"Stapleton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7737-6493","authenticated-orcid":false,"given":"Chioma M.","family":"Okeoma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,12,22]]},"reference":[{"key":"4068_CR1","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1074\/mcp.RA119.001594","volume":"19","author":"H Kaddour","year":"2020","unstructured":"Kaddour H, Lyu Y, Welch JL, Paromov V, Mandape SN, Sakhare SS, Pandhare J, Stapleton JT, Pratap S, Dash C, Okeoma CM (2020) Proteomics profiling of autologous blood and semen exosomes from HIV-infected and uninfected individuals reveals compositional and functional variabilities. Mol Cell Proteomics 19:78\u2013100","journal-title":"Mol Cell Proteomics"},{"key":"4068_CR2","doi-asserted-by":"crossref","first-page":"5361","DOI":"10.3390\/ijms21155361","volume":"21","author":"H Kaddour","year":"2020","unstructured":"Kaddour H, Lyu Y, Shouman N, Mohan M, Okeoma CM (2020) Development of novel high-resolution size-guided turbidimetry-enabled particle purification liquid chromatography (PPLC): extracellular vesicles and membraneless condensates in focus. Int J Mol Sci 21:5361","journal-title":"Int J Mol Sci"},{"key":"4068_CR3","doi-asserted-by":"crossref","first-page":"7290","DOI":"10.1093\/nar\/gku347","volume":"42","author":"L Vojtech","year":"2014","unstructured":"Vojtech L, Woo S, Hughes S, Levy C, Ballweber L, Sauteraud RP, Strobl J, Westerberg K, Gottardo R, Tewari M, Hladik F (2014) Exosomes in human semen carry a distinctive repertoire of small non-coding RNAs with potential regulatory functions. Nucleic Acids Res 42:7290\u20137304","journal-title":"Nucleic Acids Res"},{"key":"4068_CR4","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.virol.2015.03.040","volume":"482","author":"MN Madison","year":"2015","unstructured":"Madison MN, Jones PH, Okeoma CM (2015) Exosomes in human semen restrict HIV-1 transmission by vaginal cells and block intravaginal replication of LP-BM5 murine AIDS virus complex. Virology 482:189\u2013201","journal-title":"Virology"},{"key":"4068_CR5","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s12977-014-0102-z","volume":"11","author":"MN Madison","year":"2014","unstructured":"Madison MN, Roller RJ, Okeoma CM (2014) Human semen contains exosomes with potent anti-HIV-1 activity. Retrovirology 11:102","journal-title":"Retrovirology"},{"issue":"21","key":"4068_CR6","doi-asserted-by":"crossref","first-page":"e00731","DOI":"10.1128\/JVI.00731-18","volume":"92","author":"JL Welch","year":"2018","unstructured":"Welch JL, Kaddour H, Schlievert PM, Stapleton JT, Okeoma CM (2018) Semen exosomes promote transcriptional silencing of HIV-1 by disrupting NF-kB\/Sp1\/Tat circuitry. J Virol 92(21):e00731","journal-title":"J Virol"},{"key":"4068_CR7","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1097\/QAI.0000000000002233","volume":"83","author":"JL Welch","year":"2020","unstructured":"Welch JL, Kaddour H, Winchester L, Fletcher CV, Stapleton JT, Okeoma CM (2020) Semen extracellular vesicles from HIV-1-infected individuals inhibit HIV-1 replication In Vitro, and extracellular vesicles carry antiretroviral drugs In Vivo. J Acquir Immune Defic Syndr 83:90\u201398","journal-title":"J Acquir Immune Defic Syndr"},{"key":"4068_CR8","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/1873-3468.13653","volume":"594","author":"JL Welch","year":"2020","unstructured":"Welch JL, Kaufman TM, Stapleton JT, Okeoma CM (2020) Semen exosomes inhibit HIV infection and HIV-induced proinflammatory cytokine production independent of the activation state of primary lymphocytes. FEBS Lett 594:695\u2013709","journal-title":"FEBS Lett"},{"key":"4068_CR9","doi-asserted-by":"crossref","first-page":"45034","DOI":"10.1038\/srep45034","volume":"7","author":"JL Welch","year":"2017","unstructured":"Welch JL, Madison MN, Margolick JB, Galvin S, Gupta P, Martinez-Maza O, Dash C, Okeoma CM (2017) Effect of prolonged freezing of semen on exosome recovery and biologic activity. Sci Rep 7:45034","journal-title":"Sci Rep"},{"key":"4068_CR10","first-page":"e0525","volume":"94","author":"EGM de Menezes","year":"2020","unstructured":"de Menezes EGM, Jang K, George AF, Nyegaard M, Neidleman J, Inglis HC, Danesh A, Deng X, Afshari A, Kim YH (2020) Seminal plasma-derived extracellular-vesicle fractions from HIV-infected men exhibit unique microRNA signatures and induce a proinflammatory response in cells isolated from the female reproductive tract. J Virol 94:e0525","journal-title":"J Virol"},{"key":"4068_CR11","doi-asserted-by":"crossref","first-page":"e13220","DOI":"10.1111\/and.13220","volume":"50","author":"LA Ouattara","year":"2018","unstructured":"Ouattara LA, Anderson SM, Doncel GF (2018) Seminal exosomes and HIV-1 transmission. Andrologia 50:e13220","journal-title":"Andrologia"},{"key":"4068_CR12","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ejogrb.2019.02.010","volume":"235","author":"S Paktinat","year":"2019","unstructured":"Paktinat S, Hashemi SM, Novin MG, Mohammadi-Yeganeh S, Salehpour S, Karamian A, Nazarian H (2019) Seminal exosomes induce interleukin-6 and interleukin-8 secretion by human endometrial stromal cells. Eur J Obstet Gynecol Reprod Biol 235:71\u201376","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"4068_CR13","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1210\/er.2017-00229","volume":"39","author":"C Simon","year":"2018","unstructured":"Simon C, Greening DW, Bolumar D, Balaguer N, Salamonsen LA, Vilella F (2018) Extracellular vesicles in human reproduction in health and disease. Endocr Rev 39:292\u2013332","journal-title":"Endocr Rev"},{"key":"4068_CR14","doi-asserted-by":"crossref","first-page":"R21","DOI":"10.1530\/REP-13-0058","volume":"146","author":"R Sullivan","year":"2013","unstructured":"Sullivan R, Saez F (2013) Epididymosomes, prostasomes, and liposomes: their roles in mammalian male reproductive physiology. Reproduction 146:R21\u2013R35","journal-title":"Reproduction"},{"key":"4068_CR15","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.2105\/AJPH.2012.301162","volume":"103","author":"MJ Mimiaga","year":"2013","unstructured":"Mimiaga MJ, Reisner SL, Grasso C, Crane HM, Safren SA, Kitahata MM, Schumacher JE, Mathews WC, Mayer KH (2013) Substance use among HIV-infected patients engaged in primary care in the United States: findings from the Centers for AIDS Research Network of Integrated Clinical Systems cohort. Am J Public Health 103:1457\u20131467","journal-title":"Am J Public Health"},{"key":"4068_CR16","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.etp.2008.08.001","volume":"61","author":"A Mohammadi","year":"2009","unstructured":"Mohammadi A, Darabi M, Nasry M, Saabet-Jahromi MJ, Malek-Pour-Afshar R, Sheibani H (2009) Effect of opium addiction on lipid profile and atherosclerosis formation in hypercholesterolemic rabbits. Exp Toxicol Pathol 61:145\u2013149","journal-title":"Exp Toxicol Pathol"},{"key":"4068_CR17","first-page":"154","volume":"16","author":"H Roohafza","year":"2013","unstructured":"Roohafza H, Talaei M, Sadeghi M, Haghani P, Shokouh P, Sarrafzadegan N (2013) Opium decreases the age at myocardial infarction and sudden cardiac death: a long- and short-term outcome evaluation. Arch Iran Med 16:154\u2013160","journal-title":"Arch Iran Med"},{"key":"4068_CR18","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.imlet.2013.04.003","volume":"152","author":"S Nabati","year":"2013","unstructured":"Nabati S, Asadikaram G, Arababadi MK, Shahabinejad G, Rezaeian M, Mahmoodi M, Kennedy D (2013) The plasma levels of the cytokines in opium-addicts and the effects of opium on the cytokines secretion by their lymphocytes. Immunol Lett 152:42\u201346","journal-title":"Immunol Lett"},{"key":"4068_CR19","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1074\/jbc.M115.694133","volume":"291","author":"B Saha","year":"2016","unstructured":"Saha B, Momen-Heravi F, Kodys K, Szabo G (2016) MicroRNA cargo of extracellular vesicles from alcohol-exposed monocytes signals naive monocytes to differentiate into M2 macrophages. J Biol Chem 291:149\u2013159","journal-title":"J Biol Chem"},{"key":"4068_CR20","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1186\/s12967-015-0623-9","volume":"13","author":"F Momen-Heravi","year":"2015","unstructured":"Momen-Heravi F, Saha B, Kodys K, Catalano D, Satishchandran A, Szabo G (2015) Increased number of circulating exosomes and their microRNA cargos are potential novel biomarkers in alcoholic hepatitis. J Transl Med 13:261","journal-title":"J Transl Med"},{"key":"4068_CR21","doi-asserted-by":"crossref","first-page":"9991","DOI":"10.1038\/srep09991","volume":"5","author":"F Momen-Heravi","year":"2015","unstructured":"Momen-Heravi F, Bala S, Kodys K, Szabo G (2015) Exosomes derived from alcohol-treated hepatocytes horizontally transfer liver specific miRNA-122 and sensitize monocytes to LPS. Sci Rep 5:9991","journal-title":"Sci Rep"},{"key":"4068_CR22","doi-asserted-by":"crossref","first-page":"515","DOI":"10.2164\/jandrol.110.011874","volume":"33","author":"CM Fronczak","year":"2012","unstructured":"Fronczak CM, Kim ED, Barqawi AB (2012) The insults of illicit drug use on male fertility. J Androl 33:515\u2013528","journal-title":"J Androl"},{"key":"4068_CR23","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1093\/infdis\/164.3.464","volume":"164","author":"JN Krieger","year":"1991","unstructured":"Krieger JN, Coombs RW, Collier AC, Koehler JK, Ross SO, Chaloupka K, Murphy VL, Corey L (1991) Fertility parameters in men infected with human immunodeficiency virus. J Infect Dis 164:464\u2013469","journal-title":"J Infect Dis"},{"key":"4068_CR24","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1468-1293.2010.00868.x","volume":"12","author":"J Nicopoullos","year":"2011","unstructured":"Nicopoullos J, Almeida P, Vourliotis M, Gilling-Smith C (2011) A decade of the sperm-washing programme: correlation between markers of HIV and seminal parameters. HIV Med 12:195\u2013201","journal-title":"HIV Med"},{"key":"4068_CR25","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1093\/humrep\/17.8.2112","volume":"17","author":"E Dulioust","year":"2002","unstructured":"Dulioust E, Du AL, Costagliola D, Guibert J, Kunstmann J-M, Heard I, Juillard J-C, Salmon D, Leruez-Ville M, Mandelbrot L (2002) Semen alterations in HIV-1 infected men. Hum Reprod 17:2112\u20132118","journal-title":"Hum Reprod"},{"key":"4068_CR26","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1016\/j.lfs.2010.10.029","volume":"88","author":"X Wang","year":"2011","unstructured":"Wang X, Ho W-Z (2011) Drugs of abuse and HIV infection\/replication: implications for mother\u2013fetus transmission. Life Sci 88:972\u2013979","journal-title":"Life Sci"},{"key":"4068_CR27","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1086\/433175","volume":"41","author":"F Kapadia","year":"2005","unstructured":"Kapadia F, Vlahov D, Donahoe RM, Friedland G (2005) The role of substance abuse in HIV disease progression: reconciling differences from laboratory and epidemiologic investigations. Clin Infect Dis 41:1027\u20131034","journal-title":"Clin Infect Dis"},{"key":"4068_CR28","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/aja.2009.26","volume":"11","author":"J Wang","year":"2009","unstructured":"Wang J, Wang J, Zhang H-R, Shi H-J, Ma D, Zhao H-X, Lin B, Li R-S (2009) Proteomic analysis of seminal plasma from asthenozoospermia patients reveals proteins that affect oxidative stress responses and semen quality. Asian J Androl 11:484","journal-title":"Asian J Androl"},{"key":"4068_CR29","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1021\/pr200812p","volume":"11","author":"I Batruch","year":"2012","unstructured":"Batruch I, Smith CR, Mullen BJ, Grober E, Lo KC, Diamandis EP, Jarvi KA (2012) Analysis of seminal plasma from patients with non-obstructive azoospermia and identification of Candidate Biomarkers of Male Infertility. J Proteome Res 11:1503\u20131511","journal-title":"J Proteome Res"},{"key":"4068_CR30","doi-asserted-by":"crossref","first-page":"e004127","DOI":"10.1074\/mcp.M110.004127","volume":"10","author":"AP Drabovich","year":"2011","unstructured":"Drabovich AP, Jarvi K, Diamandis EP (2011) Verification of male infertility biomarkers in seminal plasma by multiplex selected reaction monitoring assay. Mol Cell Prot 10:e004127","journal-title":"Mol Cell Prot"},{"key":"4068_CR31","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1093\/molehr\/gas022","volume":"18","author":"W Wu","year":"2012","unstructured":"Wu W, Hu Z, Qin Y, Dong J, Dai J, Lu C, Zhang W, Shen H, Xia Y, Wang X (2012) Seminal plasma microRNAs: potential biomarkers for spermatogenesis status. Mol Hum Reprod 18:489\u2013497","journal-title":"Mol Hum Reprod"},{"key":"4068_CR32","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1158\/1078-0432.CCR-05-1696","volume":"12","author":"L-Y Luo","year":"2006","unstructured":"Luo L-Y, Shan SJ, Elliott MB, Soosaipillai A, Diamandis EP (2006) Purification and characterization of human kallikrein 11, a candidate prostate and ovarian cancer biomarker, from seminal plasma. Clin Cancer Res 12:742\u2013750","journal-title":"Clin Cancer Res"},{"key":"4068_CR33","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/nrurol.2014.74","volume":"11","author":"AP Drabovich","year":"2014","unstructured":"Drabovich AP, Saraon P, Jarvi K, Diamandis EP (2014) Seminal plasma as a diagnostic fluid for male reproductive system disorders. Nat Rev Urol 11:278","journal-title":"Nat Rev Urol"},{"key":"4068_CR34","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1007\/s12020-016-1150-z","volume":"57","author":"M Pelloni","year":"2017","unstructured":"Pelloni M, Coltrinari G, Paoli D, Pallotti F, Lombardo F, Lenzi A, Gandini L (2017) Differential expression of miRNAs in the seminal plasma and serum of testicular cancer patients. Endocrine 57:518\u2013527","journal-title":"Endocrine"},{"key":"4068_CR35","doi-asserted-by":"crossref","first-page":"24229","DOI":"10.1038\/srep24229","volume":"6","author":"Y Hong","year":"2016","unstructured":"Hong Y, Wang C, Fu Z, Liang H, Zhang S, Lu M, Sun W, Ye C, Zhang C-Y, Zen K (2016) Systematic characterization of seminal plasma piRNAs as molecular biomarkers for male infertility. Sci Rep 6:24229","journal-title":"Sci Rep"},{"key":"4068_CR36","doi-asserted-by":"crossref","first-page":"13772","DOI":"10.1038\/s41598-019-50172-6","volume":"9","author":"M Barcel\u00f3","year":"2019","unstructured":"Barcel\u00f3 M, Castells M, Bassas L, Vigu\u00e9s F, Larriba S (2019) Semen miRNAs contained in exosomes as non-invasive biomarkers for prostate cancer diagnosis. Sci Rep 9:13772","journal-title":"Sci Rep"},{"key":"4068_CR37","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.jprot.2012.10.023","volume":"78","author":"A D\u2019Alessandro","year":"2013","unstructured":"D\u2019Alessandro A, Zolla L (2013) Meat science: from proteomics to integrated omics towards system biology. J Proteomics 78:558\u2013577","journal-title":"J Proteomics"},{"key":"4068_CR38","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.cbpa.2009.09.022","volume":"13","author":"A Fukushima","year":"2009","unstructured":"Fukushima A, Kusano M, Redestig H, Arita M, Saito K (2009) Integrated omics approaches in plant systems biology. Curr Opin Chem Biol 13:532\u2013538","journal-title":"Curr Opin Chem Biol"},{"key":"4068_CR39","doi-asserted-by":"crossref","first-page":"R21","DOI":"10.1530\/JME-18-0055","volume":"62","author":"BB Misra","year":"2019","unstructured":"Misra BB, Langefeld C, Olivier M, Cox LA (2019) Integrated omics: tools, advances and future approaches. J Mol Endocrinol 62:R21\u2013R45","journal-title":"J Mol Endocrinol"},{"key":"4068_CR40","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.3390\/cells8091027","volume":"8","author":"Y Lyu","year":"2019","unstructured":"Lyu Y, Kaddour H, Kopcho S, Panzner TD, Shouman N, Kim E-Y, Martinson J, McKay H, Martinez-Maza O, Margolick JB et al (2019) Human immunodeficiency virus (HIV) infection and use of illicit substances promote secretion of semen exosomes that enhance monocyte adhesion and induce actin reorganization and chemotactic migration. Cells 8:1027","journal-title":"Cells"},{"key":"4068_CR41","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1471-2172-11-30","volume":"11","author":"S Seidler","year":"2010","unstructured":"Seidler S, Zimmermann HW, Bartneck M, Trautwein C, Tacke F (2010) Age-dependent alterations of monocyte subsets and monocyte-related chemokine pathways in healthy adults. BMC Immunol 11:30","journal-title":"BMC Immunol"},{"key":"4068_CR42","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.0818-9641.2004.01242.x","volume":"82","author":"M De Martinis","year":"2004","unstructured":"De Martinis M, Modesti M, Ginaldi L (2004) Phenotypic and functional changes of circulating monocytes and polymorphonuclear leucocytes from elderly persons. Immunol Cell Biol 82:415\u2013420","journal-title":"Immunol Cell Biol"},{"key":"4068_CR43","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1093\/cvr\/cvv147","volume":"107","author":"T Gerhardt","year":"2015","unstructured":"Gerhardt T, Ley K (2015) Monocyte trafficking across the vessel wall. Cardiovasc Res 107:321\u2013330","journal-title":"Cardiovasc Res"},{"key":"4068_CR44","doi-asserted-by":"crossref","first-page":"e160","DOI":"10.1371\/journal.pbio.0030160","volume":"3","author":"CM Witt","year":"2005","unstructured":"Witt CM, Raychaudhuri S, Schaefer B, Chakraborty AK, Robey EA (2005) Directed migration of positively selected thymocytes visualized in real time. PLoS Biol 3:e160","journal-title":"PLoS Biol"},{"key":"4068_CR45","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1093\/cvr\/cvq040","volume":"86","author":"CH Wong","year":"2010","unstructured":"Wong CH, Heit B, Kubes P (2010) Molecular regulators of leucocyte chemotaxis during inflammation. Cardiovasc Res 86:183\u2013191","journal-title":"Cardiovasc Res"},{"key":"4068_CR46","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/84219","volume":"2","author":"B Moser","year":"2001","unstructured":"Moser B, Loetscher P (2001) Lymphocyte traffic control by chemokines. Nat Immunol 2:123\u2013128","journal-title":"Nat Immunol"},{"key":"4068_CR47","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1093\/emboj\/18.3.501","volume":"18","author":"F S\u00e1nchez-Madrid","year":"1999","unstructured":"S\u00e1nchez-Madrid F, del Pozo MA (1999) Leukocyte polarization in cell migration and immune interactions. EMBO J 18:501\u2013511","journal-title":"EMBO J"},{"key":"4068_CR48","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0065-2776(08)60910-4","volume":"74","author":"P Loetscher","year":"1999","unstructured":"Loetscher P, Moser B, Baggiolini M (1999) Chemokines and their receptors in lymphocyte traffic and HIV infection. Adv Immunol 74:127\u2013180","journal-title":"Adv Immunol"},{"key":"4068_CR49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2172-12-64","volume":"12","author":"S Paskauskas","year":"2011","unstructured":"Paskauskas S, Parseliunas A, Kerkadze V, Nobiling R, Schmidt J, Ryschich E (2011) Blockade of leukocyte haptokinesis and haptotaxis by ketoprofen, diclofenac and SC-560. BMC Immunol 12:1\u20139","journal-title":"BMC Immunol"},{"key":"4068_CR50","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nri3641","volume":"14","author":"W Weninger","year":"2014","unstructured":"Weninger W, Biro M, Jain R (2014) Leukocyte migration in the interstitial space of non-lymphoid organs. Nat Rev Immunol 14:232\u2013246","journal-title":"Nat Rev Immunol"},{"key":"4068_CR51","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.bbagen.2004.10.012","volume":"1721","author":"L Ganiko","year":"2005","unstructured":"Ganiko L, Martins AR, Freym\u00fcller E, Mortara RA, Roque-Barreira M-C (2005) Lectin KM+-induced neutrophil haptotaxis involves binding to laminin. Biochim Biophys Acta 1721:152\u2013163","journal-title":"Biochim Biophys Acta"},{"key":"4068_CR52","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1093\/aje\/126.2.310","volume":"126","author":"RA Kaslow","year":"1987","unstructured":"Kaslow RA, Ostrow DG, Detels R, Phair JP, Polk BF (1987) RINALDO Jr CR, Study MAC: The Multicenter AIDS Cohort Study: rationale, organization, and selected characteristics of the participants. Am J Epidemiol 126:310\u2013318","journal-title":"Am J Epidemiol"},{"key":"4068_CR53","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.puhe.2011.11.013","volume":"126","author":"R Detels","year":"2012","unstructured":"Detels R, Jacobson L, Margolick J, Martinez-Maza O, Mu\u00f1oz A, Phair J, Rinaldo C, Wolinsky S (2012) The multicenter AIDS cohort study, 1983 to\u2026. Public Health 126:196\u2013198","journal-title":"Public Health"},{"key":"4068_CR54","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.3390\/v12101117","volume":"12","author":"H Kaddour","year":"2020","unstructured":"Kaddour H, Panzner TD, Welch JL, Shouman N, Mohan M, Stapleton JT, Okeoma CM (2020) Electrostatic surface properties of blood and semen extracellular vesicles: implications of sialylation and HIV-induced changes on EV internalization. Viruses 12:1117","journal-title":"Viruses"},{"key":"4068_CR55","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/10890","volume":"17","author":"AJ Link","year":"1999","unstructured":"Link AJ, Eng J, Schieltz DM, Carmack E, Mize GJ, Morris DR, Garvik BM, Yates JR (1999) Direct analysis of protein complexes using mass spectrometry. Nat Biotechnol 17:676\u2013682","journal-title":"Nat Biotechnol"},{"key":"4068_CR56","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1093\/sysbio\/45.3.380","volume":"45","author":"R Real","year":"1996","unstructured":"Real R, Vargas JM (1996) The probabilistic basis of Jaccard\u2019s index of similarity. Syst Biol 45:380\u2013385","journal-title":"Syst Biol"},{"key":"4068_CR57","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1111\/andr.12412","volume":"5","author":"C Yang","year":"2017","unstructured":"Yang C, Guo WB, Zhang WS, Bian J, Yang JK, Zhou QZ, Chen MK, Peng W, Qi T, Wang CY (2017) Comprehensive proteomics analysis of exosomes derived from human seminal plasma. Andrology 5:1007\u20131015","journal-title":"Andrology"},{"key":"4068_CR58","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1093\/humrep\/dez114","volume":"34","author":"V Murdica","year":"2019","unstructured":"Murdica V, Cermisoni GC, Zarovni N, Salonia A, Vigan\u00f2 P, Vago R (2019) Proteomic analysis reveals the negative modulator of sperm function glycodelin as over-represented in semen exosomes isolated from asthenozoospermic patients. Hum Reprod 34:1416\u20131427","journal-title":"Hum Reprod"},{"key":"4068_CR59","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1002\/mrd.23224","volume":"86","author":"Y Lin","year":"2019","unstructured":"Lin Y, Liang A, He Y, Li Z, Li Z, Wang G, Sun F (2019) Proteomic analysis of seminal extracellular vesicle proteins involved in asthenozoospermia by iTRAQ. Mol Reprod Dev 86:1094\u20131105","journal-title":"Mol Reprod Dev"},{"key":"4068_CR60","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1074\/mcp.RA119.001594","volume":"19","author":"H Kaddour","year":"2020","unstructured":"Kaddour H, Lyu Y, Welch JL, Paromov V, Mandape SN, Sakhare SS, Pandhare J, Stapleton JT, Pratap S, Dash C (2020) Proteomics profiling of autologous blood and semen exosomes from HIV-infected and uninfected individuals reveals compositional and functional variabilities. Mol Cell Proteomics 19:78\u2013100","journal-title":"Mol Cell Proteomics"},{"key":"4068_CR61","doi-asserted-by":"crossref","first-page":"W214","DOI":"10.1093\/nar\/gkq537","volume":"38","author":"D Warde-Farley","year":"2010","unstructured":"Warde-Farley D, Donaldson SL, Comes O, Zuberi K, Badrawi R, Chao P, Franz M, Grouios C, Kazi F, Lopes CT (2010) The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function. Nucleic Acids Res 38:W214\u2013W220","journal-title":"Nucleic Acids Res"},{"key":"4068_CR62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13059-018-1488-z","volume":"19","author":"S Barber\u00e1n-Soler","year":"2018","unstructured":"Barber\u00e1n-Soler S, Vo JM, Hogans RE, Dallas A, Johnston BH, Kazakov SA (2018) Decreasing miRNA sequencing bias using a single adapter and circularization approach. Genome Biol 19:1\u20139","journal-title":"Genome Biol"},{"key":"4068_CR63","doi-asserted-by":"crossref","first-page":"D925","DOI":"10.1093\/nar\/gkw1084","volume":"45","author":"IF Chung","year":"2017","unstructured":"Chung IF, Chang S-J, Chen C-Y, Liu S-H, Li C-Y, Chan C-H, Shih C-C, Cheng W-C (2017) YM500v3: a database for small RNA sequencing in human cancer research. Nucleic Acids Res 45:D925\u2013D931","journal-title":"Nucleic Acids Res"},{"key":"4068_CR64","doi-asserted-by":"crossref","first-page":"W460","DOI":"10.1093\/nar\/gkv403","volume":"43","author":"IS Vlachos","year":"2015","unstructured":"Vlachos IS, Zagganas K, Paraskevopoulou MD, Georgakilas G, Karagkouni D, Vergoulis T, Dalamagas T, Hatzigeorgiou AG (2015) DIANA-miRPath v3.0: deciphering microRNA function with experimental support. Nucleic Acids Res 43:W460\u2013W466","journal-title":"Nucleic Acids Res"},{"key":"4068_CR65","doi-asserted-by":"crossref","first-page":"359369","DOI":"10.1155\/2012\/359369","volume":"2012","author":"SP Persengiev","year":"2012","unstructured":"Persengiev SP, Kondova II, Bontrop RE (2012) The Impact of MicroRNAs on Brain Aging and Neurodegeneration. Curr Gerontol Geriatr Res 2012:359369","journal-title":"Curr Gerontol Geriatr Res"},{"key":"4068_CR66","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1097\/WNR.0b013e3280148e8b","volume":"18","author":"WJ Lukiw","year":"2007","unstructured":"Lukiw WJ (2007) Micro-RNA speciation in fetal, adult and Alzheimer\u2019s disease hippocampus. NeuroReport 18:297\u2013300","journal-title":"NeuroReport"},{"key":"4068_CR67","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.bbrc.2019.10.083","volume":"521","author":"L Wu","year":"2020","unstructured":"Wu L, Zhang G, Guo C, Zhao X, Shen D, Yang N (2020) MiR-128-3p mediates TNF-\u03b1-induced inflammatory responses by regulating Sirt1 expression in bone marrow mesenchymal stem cells. Biochem Biophys Res Commun 521:98\u2013105","journal-title":"Biochem Biophys Res Commun"},{"key":"4068_CR68","doi-asserted-by":"crossref","first-page":"12881","DOI":"10.1111\/adb.12881","volume":"26","author":"J Li","year":"2020","unstructured":"Li J, Zhu L, Su H, Liu D, Yan Z, Ni T, Wei H, Goh ELK, Chen T (2020) Regulation of miR-128 in the nucleus accumbens affects methamphetamine-induced behavioral sensitization by modulating proteins involved in neuroplasticity. Addict Biol 26:12881","journal-title":"Addict Biol"},{"key":"4068_CR69","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1093\/infdis\/jiu006","volume":"209","author":"T Zhang","year":"2014","unstructured":"Zhang T, Yu J, Zhang Y, Li L, Chen Y, Li D, Liu F, Zhang CY, Gu H, Zen K (2014) Salmonella enterica serovar enteritidis modulates intestinal epithelial miR-128 levels to decrease macrophage recruitment via macrophage colony-stimulating factor. J Infect Dis 209:2000\u20132011","journal-title":"J Infect Dis"},{"key":"4068_CR70","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1002\/jcp.21452","volume":"216","author":"D Eletto","year":"2008","unstructured":"Eletto D, Russo G, Passiatore G, Del Valle L, Giordano A, Khalili K, Gualco E, Peruzzi F (2008) Inhibition of SNAP25 expression by HIV-1 Tat involves the activity of mir-128a. J Cell Physiol 216:764\u2013770","journal-title":"J Cell Physiol"},{"key":"4068_CR71","doi-asserted-by":"crossref","first-page":"e00015","DOI":"10.1128\/JVI.00015-18","volume":"92","author":"M Carossino","year":"2018","unstructured":"Carossino M, Dini P, Kalbfleisch TS, Loynachan AT, Canisso IF, Shuck KM, Timoney PJ, Cook RF, Balasuriya UBR (2018) Downregulation of microRNA eca-mir-128 in seminal exosomes and enhanced expression of CXCL16 in the stallion reproductive tract are Associated with long-term persistence of equine arteritis virus. J Virol 92:e00015","journal-title":"J Virol"},{"key":"4068_CR72","doi-asserted-by":"crossref","first-page":"437","DOI":"10.4331\/wjbc.v5.i4.437","volume":"5","author":"VP Bondanese","year":"2014","unstructured":"Bondanese VP, Francisco-Garcia A, Bedke N, Davies DE, Sanchez-Elsner T (2014) Identification of host miRNAs that may limit human rhinovirus replication. World J Biol Chem 5:437\u2013456","journal-title":"World J Biol Chem"},{"key":"4068_CR73","doi-asserted-by":"crossref","first-page":"15870","DOI":"10.1038\/ncomms15870","volume":"8","author":"J Cai","year":"2017","unstructured":"Cai J, Fang L, Huang Y, Li R, Xu X, Hu Z, Zhang L, Yang Y, Zhu X, Zhang H et al (2017) Simultaneous overactivation of Wnt\/\u03b2-catenin and TGF\u03b2 signalling by miR-128-3p confers chemoresistance-associated metastasis in NSCLC. Nat Commun 8:15870","journal-title":"Nat Commun"},{"key":"4068_CR74","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.04263","author":"E Franzoni","year":"2015","unstructured":"Franzoni E, Booker SA, Parthasarathy S, Rehfeld F, Grosser S, Srivatsa S, Fuchs HR, Tarabykin V, Vida I, Wulczyn FG (2015) miR-128 regulates neuronal migration, outgrowth and intrinsic excitability via the intellectual disability gene Phf6. Elife. https:\/\/doi.org\/10.7554\/eLife.04263","journal-title":"Elife"},{"key":"4068_CR75","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s12943-019-0981-7","volume":"18","author":"T Liu","year":"2019","unstructured":"Liu T, Zhang X, Du L, Wang Y, Liu X, Tian H, Wang L, Li P, Zhao Y, Duan W et al (2019) Exosome-transmitted miR-128-3p increase chemosensitivity of oxaliplatin-resistant colorectal cancer. Mol Cancer 18:43","journal-title":"Mol Cancer"},{"key":"4068_CR76","doi-asserted-by":"crossref","first-page":"16699","DOI":"10.1038\/s41598-018-35139-3","volume":"8","author":"J Pan","year":"2018","unstructured":"Pan J, Zhou C, Zhao X, He J, Tian H, Shen W, Han Y, Chen J, Fang S, Meng X et al (2018) A two-miRNA signature (miR-33a-5p and miR-128-3p) in whole blood as potential biomarker for early diagnosis of lung cancer. Sci Rep 8:16699","journal-title":"Sci Rep"},{"key":"4068_CR77","doi-asserted-by":"crossref","first-page":"8653","DOI":"10.2147\/OTT.S212352","volume":"12","author":"L Yang","year":"2019","unstructured":"Yang L, Zhang L, Lu L, Wang Y (2019) Long noncoding RNA SNHG16 sponges miR-182-5p and miR-128-3p to promote retinoblastoma cell migration and invasion by targeting LASP1. Onco Targets Ther 12:8653\u20138662","journal-title":"Onco Targets Ther"},{"key":"4068_CR78","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1093\/abbs\/gmx132","volume":"50","author":"L Zhao","year":"2018","unstructured":"Zhao L, Li R, Xu S, Li Y, Zhao P, Dong W, Liu Z, Zhao Q, Tan B (2018) Tumor suppressor miR-128-3p inhibits metastasis and epithelial-mesenchymal transition by targeting ZEB1 in esophageal squamous-cell cancer. Acta Biochim Biophys Sin (Shanghai) 50:171\u2013180","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"4068_CR79","first-page":"6940","volume":"16","author":"T Zhou","year":"2018","unstructured":"Zhou T, Wu L, Wang Q, Jiang Z, Li Y, Ma N, Chen W, Hou Z, Gan W, Chen S (2018) MicroRNA-128 targeting RPN2 inhibits cell proliferation and migration through the Akt-p53-cyclin pathway in colorectal cancer cells. Oncol Lett 16:6940\u20136949","journal-title":"Oncol Lett"},{"key":"4068_CR80","doi-asserted-by":"crossref","first-page":"3183","DOI":"10.3892\/ol.2015.3689","volume":"10","author":"XU Zhou","year":"2015","unstructured":"Zhou XU, Qi L, Tong S, Cui YU, Chen J, Huang T, Chen Z, Zu XB (2015) miR-128 downregulation promotes growth and metastasis of bladder cancer cells and involves VEGF-C upregulation. Oncol Lett 10:3183\u20133190","journal-title":"Oncol Lett"},{"key":"4068_CR81","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/cbf.3365","volume":"36","author":"D Kong","year":"2018","unstructured":"Kong D, Zhang Z (2018) NAIF1 suppresses osteosarcoma progression and is regulated by miR-128. Cell Biochem Funct 36:443\u2013449","journal-title":"Cell Biochem Funct"},{"key":"4068_CR82","doi-asserted-by":"crossref","first-page":"957","DOI":"10.3892\/or.2014.3318","volume":"32","author":"X She","year":"2014","unstructured":"She X, Yu Z, Cui Y, Lei Q, Wang Z, Xu G, Xiang J, Wu M, Li G (2014) miR-128 and miR-149 enhance the chemosensitivity of temozolomide by Rap1B-mediated cytoskeletal remodeling in glioblastoma. Oncol Rep 32:957\u2013964","journal-title":"Oncol Rep"},{"key":"4068_CR83","doi-asserted-by":"crossref","first-page":"e0206239","DOI":"10.1371\/journal.pone.0206239","volume":"13","author":"C Sticht","year":"2018","unstructured":"Sticht C, De La Torre C, Parveen A, Gretz N (2018) miRWalk: an online resource for prediction of microRNA binding sites. PLoS ONE 13:e0206239","journal-title":"PLoS ONE"},{"key":"4068_CR84","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1177\/1753425920928449","volume":"26","author":"T Mou","year":"2020","unstructured":"Mou T, Luo Y, Huang Z, Zheng D, Pu X, Shen A, Pu J, Li T, Dai J, Chen W, Wu Z (2020) Inhibition of microRNA-128-3p alleviates liver ischaemia-reperfusion injury in mice through repressing the Rnd3\/NF-\u03baB axis. Innate Immun 26:528\u2013536","journal-title":"Innate Immun"},{"key":"4068_CR85","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1128\/JVI.01754-14","volume":"89","author":"LC Chandra","year":"2015","unstructured":"Chandra LC, Kumar V, Torben W, Vande Stouwe C, Winsauer P, Amedee A, Molina PE, Mohan M (2015) Chronic administration of Delta9-tetrahydrocannabinol induces intestinal anti-inflammatory microRNA expression during acute simian immunodeficiency virus infection of rhesus macaques. J Virol 89:1168\u20131181","journal-title":"J Virol"},{"key":"4068_CR86","doi-asserted-by":"crossref","first-page":"914","DOI":"10.3389\/fimmu.2019.00914","volume":"10","author":"V Kumar","year":"2019","unstructured":"Kumar V, Torben W, Mansfield J, Alvarez X, Vande Stouwe C, Li J, Byrareddy SN, Didier PJ, Pahar B, Molina PE, Mohan M (2019) Cannabinoid attenuation of intestinal inflammation in chronic SIV-infected rhesus macaques involves T Cell modulation and differential expression of micro-RNAs and pro-inflammatory genes. Front Immunol 10:914","journal-title":"Front Immunol"},{"key":"4068_CR87","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nmeth1019","volume":"4","author":"JE Elias","year":"2007","unstructured":"Elias JE, Gygi SP (2007) Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry. Nat Methods 4:207\u2013214","journal-title":"Nat Methods"},{"key":"4068_CR88","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1074\/mcp.M600469-MCP200","volume":"6","author":"BM Balgley","year":"2007","unstructured":"Balgley BM, Laudeman T, Yang L, Song T, Lee CS (2007) Comparative evaluation of tandem MS search algorithms using a target-decoy search strategy. Mol Cell Proteomics 6:1599\u20131608","journal-title":"Mol Cell Proteomics"},{"key":"4068_CR89","doi-asserted-by":"crossref","first-page":"4063","DOI":"10.1002\/elps.200900367","volume":"30","author":"X Fang","year":"2009","unstructured":"Fang X, Balgley BM, Wang W, Park DM, Lee CS (2009) Comparison of multidimensional shotgun technologies targeting tissue proteomics. Electrophoresis 30:4063\u20134070","journal-title":"Electrophoresis"},{"key":"4068_CR90","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1080\/15419060701755966","volume":"14","author":"AR Schenkel","year":"2007","unstructured":"Schenkel AR, Dufour EM, Chew TW, Sorg E, Muller WA (2007) The murine CD99-related molecule CD99-Like 2 (CD99L2) is an adhesion molecule involved in the inflammatory response. Cell Commun Adhes 14:227\u2013237","journal-title":"Cell Commun Adhes"},{"key":"4068_CR91","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1182\/blood-2009-12-256388","volume":"116","author":"MG Bixel","year":"2010","unstructured":"Bixel MG, Li H, Petri B, Khandoga AG, Khandoga A, Zarbock A, Wolburg-Buchholz K, Wolburg H, Sorokin L, Zeuschner D et al (2010) CD99 and CD99L2 act at the same site as, but independently of, PECAM-1 during leukocyte diapedesis. Blood 116:1172\u20131184","journal-title":"Blood"},{"key":"4068_CR92","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1126\/science.1099961","volume":"306","author":"SV Rakhilin","year":"2004","unstructured":"Rakhilin SV, Olson PA, Nishi A, Starkova NN, Fienberg AA, Nairn AC, Surmeier DJ, Greengard P (2004) A network of control mediated by regulator of calcium\/calmodulin-dependent signaling. Science 306:698\u2013701","journal-title":"Science"},{"key":"4068_CR93","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1111\/j.1460-9568.2005.03978.x","volume":"21","author":"L Smirnova","year":"2005","unstructured":"Smirnova L, Gr\u00e4fe A, Seiler A, Schumacher S, Nitsch R, Wulczyn FG (2005) Regulation of miRNA expression during neural cell specification. Eur J Neurosci 21:1469\u20131477","journal-title":"Eur J Neurosci"},{"key":"4068_CR94","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1111\/andr.12923","volume":"9","author":"L Zou","year":"2021","unstructured":"Zou L, Cheng G, Xu C, Liu H, Wang Y, Li N, Zhu C, Xia W (2021) The role of miR-128-3p through MAPK14 activation in the apoptosis of GC2 spermatocyte cell line following heat stress. Andrology 9:665\u2013672","journal-title":"Andrology"},{"key":"4068_CR95","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00015-18","author":"M Carossino","year":"2018","unstructured":"Carossino M, Dini P, Kalbfleisch TS, Loynachan AT, Canisso IF, Shuck KM, Timoney PJ, Cook RF, Balasuriya UB (2018) Downregulation of microRNA eca-mir-128 in seminal exosomes and enhanced expression of CXCL16 in the stallion reproductive tract are associated with long-term persistence of equine arteritis virus. J Virol. https:\/\/doi.org\/10.1128\/JVI.00015-18","journal-title":"J Virol"},{"key":"4068_CR96","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00364-19","author":"A Bochnakian","year":"2019","unstructured":"Bochnakian A, Zhen A, Zisoulis DG, Idica A, KewalRamani VN, Neel N, Daugaard I, Hamdorf M, Kitchen S, Lee K, Pedersen IM (2019) Interferon-inducible MicroRNA miR-128 modulates HIV-1 replication by targeting TNPO3 mRNA. J Virol. https:\/\/doi.org\/10.1128\/JVI.00364-19","journal-title":"J Virol"},{"key":"4068_CR97","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.yfrne.2013.07.007","volume":"34","author":"A Petrulis","year":"2013","unstructured":"Petrulis A (2013) Chemosignals and hormones in the neural control of mammalian sexual behavior. Front Neuroendocrinol 34:255\u2013267","journal-title":"Front Neuroendocrinol"},{"key":"4068_CR98","doi-asserted-by":"crossref","first-page":"4639","DOI":"10.1111\/bph.13206","volume":"172","author":"J Li","year":"2015","unstructured":"Li J, Xie M, Wang X, Ouyang X, Wan Y, Dong G, Yang Z, Yang J, Yue J (2015) Sex hormones regulate cerebral drug metabolism via brain miRNAs: down-regulation of brain CYP2D by androgens reduces the analgesic effects of tramadol. Br J Pharmacol 172:4639\u20134654","journal-title":"Br J Pharmacol"},{"key":"4068_CR99","first-page":"3369","volume":"15","author":"H Li","year":"2018","unstructured":"Li H, Li C, Zhou Y, Luo C, Ou J, Li J, Mo Z (2018) Expression of microRNAs in the serum exosomes of methamphetamine-dependent rats vs. ketamine-dependent rats. Exp Ther Med 15:3369\u20133375","journal-title":"Exp Ther Med"},{"key":"4068_CR100","doi-asserted-by":"crossref","first-page":"8025062","DOI":"10.1155\/2018\/8025062","volume":"2018","author":"HC Li","year":"2018","unstructured":"Li HC, Lin YB, Li C, Luo CH, Zhou YT, Ou JY, Li J, Mo ZX (2018) Expression of miRNAs in Serum Exosomes versus Hippocampus in Methamphetamine-induced rats and intervention of rhynchophylline. Evid Based Complement Alternat Med 2018:8025062","journal-title":"Evid Based Complement Alternat Med"},{"key":"4068_CR101","doi-asserted-by":"crossref","first-page":"e12028","DOI":"10.1002\/jev2.12028","volume":"10","author":"US Sandau","year":"2020","unstructured":"Sandau US, Duggan E, Shi X, Smith SJ, Huckans M, Schutzer WE, Loftis JM, Janowsky A, Nolan JP, Saugstad JA (2020) Methamphetamine use alters human plasma extracellular vesicles and their microRNA cargo: an exploratory study. J Extracell Vesicles 10:e12028","journal-title":"J Extracell Vesicles"},{"key":"4068_CR102","doi-asserted-by":"crossref","first-page":"4276","DOI":"10.1096\/fj.09-134965","volume":"23","author":"C Evangelisti","year":"2009","unstructured":"Evangelisti C, Florian MC, Massimi I, Dominici C, Giannini G, Galardi S, Bu\u00e8 MC, Massalini S, McDowell HP, Messi E et al (2009) MiR-128 up-regulation inhibits Reelin and DCX expression and reduces neuroblastoma cell motility and invasiveness. Faseb J 23:4276\u20134287","journal-title":"Faseb J"},{"key":"4068_CR103","doi-asserted-by":"crossref","first-page":"574054","DOI":"10.3389\/fmicb.2020.574054","volume":"11","author":"R Wang","year":"2020","unstructured":"Wang R, Gornalusse GG, Kim Y, Pandey U, Hladik F, Vojtech L (2020) Potent restriction of sexual Zika Virus infection by the lipid fraction of extracellular vesicles in semen. Front Microbiol 11:574054","journal-title":"Front Microbiol"},{"key":"4068_CR104","doi-asserted-by":"crossref","first-page":"356","DOI":"10.2533\/chimia.2019.356","volume":"73","author":"E Maciel","year":"2019","unstructured":"Maciel E, Mansuy IM (2019) Extracellular vesicles and their miRNA Cargo: a means of communication between soma and germline in the mammalian reproductive system. Chimia (Aarau) 73:356\u2013361","journal-title":"Chimia (Aarau)"},{"key":"4068_CR105","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1038\/s41467-020-15305-w","volume":"11","author":"JC Chan","year":"2020","unstructured":"Chan JC, Morgan CP, Adrian Leu N, Shetty A, Cisse YM, Nugent BM, Morrison KE, Ja\u0161arevi\u0107 E, Huang W, Kanyuch N et al (2020) Reproductive tract extracellular vesicles are sufficient to transmit intergenerational stress and program neurodevelopment. Nat Commun 11:1499","journal-title":"Nat Commun"},{"key":"4068_CR106","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cell.2004.12.035","volume":"120","author":"BP Lewis","year":"2005","unstructured":"Lewis BP, Burge CB, Bartel DP (2005) Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 120:15\u201320","journal-title":"Cell"},{"key":"4068_CR107","doi-asserted-by":"crossref","first-page":"D146","DOI":"10.1093\/nar\/gku1104","volume":"43","author":"N Wong","year":"2015","unstructured":"Wong N, Wang X (2015) miRDB: an online resource for microRNA target prediction and functional annotations. Nucleic Acids Res 43:D146\u2013D152","journal-title":"Nucleic Acids Res"},{"key":"4068_CR108","doi-asserted-by":"crossref","first-page":"D296","DOI":"10.1093\/nar\/gkx1067","volume":"46","author":"CH Chou","year":"2018","unstructured":"Chou CH, Shrestha S, Yang CD, Chang NW, Lin YL, Liao KW, Huang WC, Sun TH, Tu SJ, Lee WH et al (2018) miRTarBase update 2018: a resource for experimentally validated microRNA-target interactions. Nucleic Acids Res 46:D296-d302","journal-title":"Nucleic Acids Res"},{"key":"4068_CR109","doi-asserted-by":"crossref","first-page":"2912","DOI":"10.1093\/bioinformatics\/btv300","volume":"31","author":"W Walter","year":"2015","unstructured":"Walter W, S\u00e1nchez-Cabo F, Ricote M (2015) GOplot: an R package for visually combining expression data with functional analysis. Bioinformatics 31:2912\u20132914","journal-title":"Bioinformatics"}],"container-title":["Cellular and Molecular Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-021-04068-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00018-021-04068-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-021-04068-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T00:38:48Z","timestamp":1726360728000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00018-021-04068-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,22]]},"references-count":109,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["4068"],"URL":"https:\/\/doi.org\/10.1007\/s00018-021-04068-2","relation":{},"ISSN":["1420-682X","1420-9071"],"issn-type":[{"value":"1420-682X","type":"print"},{"value":"1420-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,22]]},"assertion":[{"value":"16 September 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 November 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 November 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 December 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was conducted according to University regulations approved by Stony Brook University Institutional Review Boards (IRB # 201608703) using de-identified human specimens obtained through the Multicenter AIDS Cohort Study (MACS).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Individuals who met the inclusion and exhibit none of the exclusion criteria and who gave written informed consent were included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}],"article-number":"5"}}