{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:10:44Z","timestamp":1790028644021,"version":"4.0.1"},"reference-count":161,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T00:00:00Z","timestamp":1640908800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T00:00:00Z","timestamp":1640908800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM134731"],"award-info":[{"award-number":["GM134731"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM098605"],"award-info":[{"award-number":["GM098605"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM141085"],"award-info":[{"award-number":["GM141085"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003334","name":"Albert J. Ryan Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003334","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Grant-in-Aid for Research Activity Start-up","award":["19K21196"],"award-info":[{"award-number":["19K21196"]}]},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell. Mol. Life Sci."],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1007\/s00018-021-04075-3","type":"journal-article","created":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T05:02:24Z","timestamp":1640926944000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Meiotic sex chromosome inactivation and the XY body: a phase separation hypothesis"],"prefix":"10.1007","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1696-6515","authenticated-orcid":false,"given":"Kris G.","family":"Alavattam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9060-2042","authenticated-orcid":false,"given":"So","family":"Maezawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9760-1595","authenticated-orcid":false,"given":"Paul R.","family":"Andreassen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1052-943X","authenticated-orcid":false,"given":"Satoshi H.","family":"Namekawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,12,31]]},"reference":[{"issue":"6","key":"4075_CR1","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/j.tcb.2018.02.004","volume":"28","author":"S Boeynaems","year":"2018","unstructured":"Boeynaems S, Alberti S, Fawzi NL, Mittag T, Polymenidou M, Rousseau F, Schymkowitz J, Shorter J, Wolozin B, Van Den Bosch L, Tompa P, Fuxreiter M (2018) Protein phase separation: a new phase in cell biology. Trends Cell Biol 28(6):420\u2013435. https:\/\/doi.org\/10.1016\/j.tcb.2018.02.004","journal-title":"Trends Cell Biol"},{"issue":"1","key":"4075_CR2","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.devcel.2020.06.033","volume":"55","author":"YG Zhao","year":"2020","unstructured":"Zhao YG, Zhang H (2020) Phase separation in membrane biology: the interplay between membrane-bound organelles and membraneless condensates. Dev Cell 55(1):30\u201344. https:\/\/doi.org\/10.1016\/j.devcel.2020.06.033","journal-title":"Dev Cell"},{"issue":"1","key":"4075_CR3","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.tibs.2015.11.001","volume":"41","author":"HB Schmidt","year":"2016","unstructured":"Schmidt HB, G\u00f6rlich D (2016) Transport selectivity of nuclear pores, phase separation, and membraneless organelles. Trends Biochem Sci 41(1):46\u201361. https:\/\/doi.org\/10.1016\/j.tibs.2015.11.001","journal-title":"Trends Biochem Sci"},{"issue":"11","key":"4075_CR4","doi-asserted-by":"publisher","first-page":"4334","DOI":"10.1073\/pnas.1017150108","volume":"108","author":"CP Brangwynne","year":"2011","unstructured":"Brangwynne CP, Mitchison TJ, Hyman AA (2011) Active liquid-like behavior of nucleoli determines their size and shape in Xenopus laevis oocytes. Proc Natl Acad Sci USA 108(11):4334\u20134339. https:\/\/doi.org\/10.1073\/pnas.1017150108","journal-title":"Proc Natl Acad Sci USA"},{"issue":"7662","key":"4075_CR5","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1038\/nature22989","volume":"547","author":"AR Strom","year":"2017","unstructured":"Strom AR, Emelyanov AV, Mir M, Fyodorov DV, Darzacq X, Karpen GH (2017) Phase separation drives heterochromatin domain formation. Nature 547(7662):241\u2013245. https:\/\/doi.org\/10.1038\/nature22989","journal-title":"Nature"},{"issue":"7662","key":"4075_CR6","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1038\/nature22822","volume":"547","author":"AG Larson","year":"2017","unstructured":"Larson AG, Elnatan D, Keenen MM, Trnka MJ, Johnston JB, Burlingame AL, Agard DA, Redding S, Narlikar GJ (2017) Liquid droplet formation by HP1\u03b1 suggests a role for phase separation in heterochromatin. Nature 547(7662):236\u2013240. https:\/\/doi.org\/10.1038\/nature22822","journal-title":"Nature"},{"issue":"6400","key":"4075_CR7","doi-asserted-by":"publisher","first-page":"aar3958","DOI":"10.1126\/science.aar3958","volume":"361","author":"BR Sabari","year":"2018","unstructured":"Sabari BR, Dall\u2019Agnese A, Boija A, Klein IA, Coffey EL, Shrinivas K, Abraham BJ, Hannett NM, Zamudio AV, Manteiga JC, Li CH, Guo YE, Day DS, Schuijers J, Vasile E, Malik S, Hnisz D, Lee TI, Cisse II, Roeder RG, Sharp PA, Chakraborty AK, Young RA (2018) Coactivator condensation at super-enhancers links phase separation and gene control. Science. 361(6400):aar3958. https:\/\/doi.org\/10.1126\/science.aar3958","journal-title":"Science."},{"issue":"1","key":"4075_CR8","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.devcel.2020.09.004","volume":"55","author":"AE Dodson","year":"2020","unstructured":"Dodson AE, Kennedy S (2020) Phase separation in germ cells and development. Dev Cell 55(1):4\u201317. https:\/\/doi.org\/10.1016\/j.devcel.2020.09.004","journal-title":"Dev Cell"},{"key":"4075_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2020.12.004","author":"C So","year":"2021","unstructured":"So C, Cheng S, Schuh M (2021) Phase separation during germline development. Trends Cell Biol. https:\/\/doi.org\/10.1016\/j.tcb.2020.12.004","journal-title":"Trends Cell Biol"},{"issue":"5935","key":"4075_CR10","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1126\/science.1172046","volume":"324","author":"CP Brangwynne","year":"2009","unstructured":"Brangwynne CP, Eckmann CR, Courson DS, Rybarska A, Hoege C, Gharakhani J, J\u00fclicher F, Hyman AA (2009) Germline P granules are liquid droplets that localize by controlled dissolution\/condensation. Science 324(5935):1729\u20131732. https:\/\/doi.org\/10.1126\/science.1172046","journal-title":"Science"},{"key":"4075_CR11","doi-asserted-by":"publisher","first-page":"21455","DOI":"10.7554\/eLife.21455","volume":"6","author":"O Rog","year":"2017","unstructured":"Rog O, K\u00f6hler S, Dernburg AF (2017) The synaptonemal complex has liquid crystalline properties and spatially regulates meiotic recombination factors. Elife 6:21455. https:\/\/doi.org\/10.7554\/eLife.21455","journal-title":"Elife"},{"key":"4075_CR12","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03374-w","author":"C Claeys Bouuaert","year":"2021","unstructured":"Claeys Bouuaert C, Pu S, Wang J, Oger C, Daccache D, Xie W, Patel DJ, Keeney S (2021) DNA-driven condensation assembles the meiotic DNA break machinery. Nature. https:\/\/doi.org\/10.1038\/s41586-021-03374-w","journal-title":"Nature"},{"issue":"1","key":"4075_CR13","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/ng1484","volume":"37","author":"JM Turner","year":"2005","unstructured":"Turner JM, Mahadevaiah SK, Fernandez-Capetillo O, Nussenzweig A, Xu X, Deng CX, Burgoyne PS (2005) Silencing of unsynapsed meiotic chromosomes in the mouse. Nat Genet 37(1):41\u201347. https:\/\/doi.org\/10.1038\/ng1484","journal-title":"Nat Genet"},{"issue":"3","key":"4075_CR14","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1128\/MCB.25.3.1041-1053.2005","volume":"25","author":"WM Baarends","year":"2005","unstructured":"Baarends WM, Wassenaar E, van der Laan R, Hoogerbrugge J, Sleddens-Linkels E, Hoeijmakers JH, de Boer P, Grootegoed JA (2005) Silencing of unpaired chromatin and histone H2A ubiquitination in mammalian meiosis. Mol Cell Biol 25(3):1041\u20131053. https:\/\/doi.org\/10.1128\/MCB.25.3.1041-1053.2005","journal-title":"Mol Cell Biol"},{"issue":"1","key":"4075_CR15","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/ng0105-11","volume":"37","author":"J Schimenti","year":"2005","unstructured":"Schimenti J (2005) Synapsis or silence. Nat Genet 37(1):11\u201313. https:\/\/doi.org\/10.1038\/ng0105-11","journal-title":"Nat Genet"},{"issue":"3","key":"4075_CR16","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/nrg2505","volume":"10","author":"PS Burgoyne","year":"2009","unstructured":"Burgoyne PS, Mahadevaiah SK, Turner JM (2009) The consequences of asynapsis for mammalian meiosis. Nat Rev Genet 10(3):207\u2013216. https:\/\/doi.org\/10.1038\/nrg2505","journal-title":"Nat Rev Genet"},{"issue":"10","key":"4075_CR17","doi-asserted-by":"publisher","first-page":"1823","DOI":"10.1242\/dev.000018","volume":"134","author":"JM Turner","year":"2007","unstructured":"Turner JM (2007) Meiotic sex chromosome inactivation. Development 134(10):1823\u20131831. https:\/\/doi.org\/10.1242\/dev.000018","journal-title":"Development"},{"key":"4075_CR18","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/s0074-7696(08)60928-6","volume":"38","author":"AJ Solari","year":"1974","unstructured":"Solari AJ (1974) The behavior of the XY pair in mammals. Int Rev Cytol 38:273\u2013317. https:\/\/doi.org\/10.1016\/s0074-7696(08)60928-6","journal-title":"Int Rev Cytol"},{"issue":"2","key":"4075_CR19","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/BF00356023","volume":"102","author":"BD McKee","year":"1993","unstructured":"McKee BD, Handel MA (1993) Sex chromosomes, recombination, and chromatin conformation. Chromosoma 102(2):71\u201380","journal-title":"Chromosoma"},{"issue":"3\u20134","key":"4075_CR20","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1159\/000076810","volume":"103","author":"S Hoyer-Fender","year":"2003","unstructured":"Hoyer-Fender S (2003) Molecular aspects of XY body formation. Cytogenet Genome Res 103(3\u20134):245\u2013255. https:\/\/doi.org\/10.1159\/000076810","journal-title":"Cytogenet Genome Res"},{"issue":"1","key":"4075_CR21","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.yexcr.2004.03.008","volume":"296","author":"MA Handel","year":"2004","unstructured":"Handel MA (2004) The XY body: a specialized meiotic chromatin domain. Exp Cell Res 296(1):57\u201363. https:\/\/doi.org\/10.1016\/j.yexcr.2004.03.008","journal-title":"Exp Cell Res"},{"issue":"7","key":"4075_CR22","doi-asserted-by":"publisher","first-page":"452","DOI":"10.4161\/epi.4.7.9923","volume":"4","author":"W Yan","year":"2009","unstructured":"Yan W, McCarrey JR (2009) Sex chromosome inactivation in the male. Epigenetics 4(7):452\u2013456. https:\/\/doi.org\/10.4161\/epi.4.7.9923","journal-title":"Epigenetics"},{"issue":"15","key":"4075_CR23","doi-asserted-by":"publisher","first-page":"2559","DOI":"10.1007\/s00018-012-0941-5","volume":"69","author":"Y Ichijima","year":"2012","unstructured":"Ichijima Y, Sin HS, Namekawa SH (2012) Sex chromosome inactivation in germ cells: emerging roles of DNA damage response pathways. Cell Mol Life Sci 69(15):2559\u20132572. https:\/\/doi.org\/10.1007\/s00018-012-0941-5","journal-title":"Cell Mol Life Sci"},{"key":"4075_CR24","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1146\/annurev-genet-112414-055145","volume":"49","author":"JM Turner","year":"2015","unstructured":"Turner JM (2015) Meiotic silencing in mammals. Annu Rev Genet 49:395\u2013412. https:\/\/doi.org\/10.1146\/annurev-genet-112414-055145","journal-title":"Annu Rev Genet"},{"issue":"9","key":"4075_CR25","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1101\/gad.2030811","volume":"25","author":"Y Ichijima","year":"2011","unstructured":"Ichijima Y, Ichijima M, Lou Z, Nussenzweig A, Camerini-Otero RD, Chen J, Andreassen PR, Namekawa SH (2011) MDC1 directs chromosome-wide silencing of the sex chromosomes in male germ cells. Genes Dev 25(9):959\u2013971. https:\/\/doi.org\/10.1101\/gad.2030811","journal-title":"Genes Dev"},{"issue":"4","key":"4075_CR26","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.1091\/mbc.e03-06-0444","volume":"15","author":"D Perera","year":"2004","unstructured":"Perera D, Perez-Hidalgo L, Moens PB, Reini K, Lakin N, Syvaoja JE, San-Segundo PA, Freire R (2004) TopBP1 and ATR colocalization at meiotic chromosomes: role of TopBP1\/Cut5 in the meiotic recombination checkpoint. Mol Biol Cell 15(4):1568\u20131579. https:\/\/doi.org\/10.1091\/mbc.e03-06-0444","journal-title":"Mol Biol Cell"},{"issue":"13","key":"4075_CR27","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.1101\/gad.219477.113","volume":"27","author":"H Royo","year":"2013","unstructured":"Royo H, Prosser H, Ruzankina Y, Mahadevaiah SK, Cloutier JM, Baumann M, Fukuda T, Hoog C, Toth A, de Rooij DG, Bradley A, Brown EJ, Turner JM (2013) ATR acts stage specifically to regulate multiple aspects of mammalian meiotic silencing. Genes Dev 27(13):1484\u20131494. https:\/\/doi.org\/10.1101\/gad.219477.113","journal-title":"Genes Dev"},{"issue":"47","key":"4075_CR28","doi-asserted-by":"publisher","first-page":"12536","DOI":"10.1073\/pnas.1712530114","volume":"114","author":"E ElInati","year":"2017","unstructured":"ElInati E, Russell HR, Ojarikre OA, Sangrithi M, Hirota T, de Rooij DG, McKinnon PJ, Turner JMA (2017) DNA damage response protein TOPBP1 regulates X chromosome silencing in the mammalian germ line. Proc Natl Acad Sci U S A 114(47):12536\u201312541. https:\/\/doi.org\/10.1073\/pnas.1712530114","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"4075_CR29","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/S1534-5807(03)00093-5","volume":"4","author":"O Fernandez-Capetillo","year":"2003","unstructured":"Fernandez-Capetillo O, Mahadevaiah SK, Celeste A, Romanienko PJ, Camerini-Otero RD, Bonner WM, Manova K, Burgoyne P, Nussenzweig A (2003) H2AX is required for chromatin remodeling and inactivation of sex chromosomes in male mouse meiosis. Dev Cell 4(4):497\u2013508","journal-title":"Dev Cell"},{"issue":"3","key":"4075_CR30","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/j.cub.2019.11.064","volume":"30","author":"H Abe","year":"2020","unstructured":"Abe H, Alavattam KG, Hu YC, Pang Q, Andreassen PR, Hegde RS, Namekawa SH (2020) the initiation of meiotic sex chromosome inactivation sequesters DNA damage signaling from autosomes in mouse spermatogenesis. Curr Biol 30(3):408-420.e405. https:\/\/doi.org\/10.1016\/j.cub.2019.11.064","journal-title":"Curr Biol"},{"issue":"5","key":"4075_CR31","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1093\/biolre\/ioaa021","volume":"102","author":"MA Handel","year":"2020","unstructured":"Handel MA (2020) The XY body: an attractive chromatin domain. Biol Reprod 102(5):985\u2013987. https:\/\/doi.org\/10.1093\/biolre\/ioaa021","journal-title":"Biol Reprod"},{"issue":"24","key":"4075_CR32","doi-asserted-by":"publisher","first-page":"2737","DOI":"10.1101\/gad.202713.112","volume":"26","author":"HS Sin","year":"2012","unstructured":"Sin HS, Barski A, Zhang F, Kartashov AV, Nussenzweig A, Chen J, Andreassen PR, Namekawa SH (2012) RNF8 regulates active epigenetic modifications and escape gene activation from inactive sex chromosomes in post-meiotic spermatids. Genes Dev 26(24):2737\u20132748. https:\/\/doi.org\/10.1101\/gad.202713.112","journal-title":"Genes Dev"},{"issue":"4","key":"4075_CR33","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1016\/j.celrep.2016.09.073","volume":"17","author":"KG Alavattam","year":"2016","unstructured":"Alavattam KG, Kato Y, Sin HS, Maezawa S, Kowalski IJ, Zhang F, Pang Q, Andreassen PR, Namekawa SH (2016) Elucidation of the Fanconi anemia protein network in meiosis and its function in the regulation of histone modifications. Cell Rep 17(4):1141\u20131157. https:\/\/doi.org\/10.1016\/j.celrep.2016.09.073","journal-title":"Cell Rep"},{"issue":"2","key":"4075_CR34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007233","volume":"14","author":"SR Adams","year":"2018","unstructured":"Adams SR, Maezawa S, Alavattam KG, Abe H, Sakashita A, Shroder M, Broering TJ, Sroga Rios J, Thomas MA, Lin X, Price CM, Barski A, Andreassen PR, Namekawa SH (2018) RNF8 and SCML2 cooperate to regulate ubiquitination and H3K27 acetylation for escape gene activation on the sex chromosomes. PLoS Genet 14(2):e1007233. https:\/\/doi.org\/10.1371\/journal.pgen.1007233","journal-title":"PLoS Genet"},{"issue":"5","key":"4075_CR35","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1016\/j.devcel.2015.01.014","volume":"32","author":"K Hasegawa","year":"2015","unstructured":"Hasegawa K, Sin HS, Maezawa S, Broering TJ, Kartashov AV, Alavattam KG, Ichijima Y, Zhang F, Bacon WC, Greis KD, Andreassen PR, Barski A, Namekawa SH (2015) SCML2 establishes the male germline epigenome through regulation of histone H2A ubiquitination. Dev Cell 32(5):574\u2013588. https:\/\/doi.org\/10.1016\/j.devcel.2015.01.014","journal-title":"Dev Cell"},{"issue":"3","key":"4075_CR36","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.molcel.2018.11.019","volume":"73","author":"Y Wang","year":"2019","unstructured":"Wang Y, Wang H, Zhang Y, Du Z, Si W, Fan S, Qin D, Wang M, Duan Y, Li L, Jiao Y, Li Y, Wang Q, Shi Q, Wu X, Xie W (2019) Reprogramming of meiotic chromatin architecture during spermatogenesis. Mol Cell. 73(3):547\u2013561. https:\/\/doi.org\/10.1016\/j.molcel.2018.11.019","journal-title":"Mol Cell."},{"issue":"3","key":"4075_CR37","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1038\/s41594-019-0187-0","volume":"26","author":"L Patel","year":"2019","unstructured":"Patel L, Kang R, Rosenberg SC, Qiu Y, Raviram R, Chee S, Hu R, Ren B, Cole F, Corbett KD (2019) Dynamic reorganization of the genome shapes the recombination landscape in meiotic prophase. Nat Struct Mol Biol 26(3):164\u2013174. https:\/\/doi.org\/10.1038\/s41594-019-0187-0","journal-title":"Nat Struct Mol Biol"},{"issue":"3","key":"4075_CR38","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1038\/s41594-019-0189-y","volume":"26","author":"KG Alavattam","year":"2019","unstructured":"Alavattam KG, Maezawa S, Sakashita A, Khoury H, Barski A, Kaplan N, Namekawa SH (2019) Attenuated chromatin compartmentalization in meiosis and its maturation in sperm development. Nat Struct Mol Biol 26(3):175\u2013184. https:\/\/doi.org\/10.1038\/s41594-019-0189-y","journal-title":"Nat Struct Mol Biol"},{"issue":"2","key":"4075_CR39","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.celrep.2019.06.037","volume":"28","author":"C Vara","year":"2019","unstructured":"Vara C, Paytuv\u00ed-Gallart A, Cuartero Y, Le Dily F, Garcia F, Salv\u00e0-Castro J, G\u00f3mez HL, Juli\u00e0 E, Moutinho C, Aiese Cigliano R, Sanseverino W, Fornas O, Pend\u00e1s AM, Heyn H, Waters PD, Marti-Renom MA, Ruiz-Herrera A (2019) Three-dimensional genomic structure and cohesin occupancy correlate with transcriptional activity during spermatogenesis. Cell Rep 28(2):352-367.e359. https:\/\/doi.org\/10.1016\/j.celrep.2019.06.037","journal-title":"Cell Rep"},{"key":"4075_CR40","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.674203","volume":"9","author":"Y Xu","year":"2021","unstructured":"Xu Y, Qiao H (2021) A hypothesis: linking phase separation to meiotic sex chromosome inactivation and sex-body formation. Front Cell Dev Biol 9:674203. https:\/\/doi.org\/10.3389\/fcell.2021.674203","journal-title":"Front Cell Dev Biol"},{"issue":"1","key":"4075_CR41","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1093\/biolre\/ioy021","volume":"99","author":"E Bolcun-Filas","year":"2018","unstructured":"Bolcun-Filas E, Handel MA (2018) Meiosis: the chromosomal foundation of reproduction. Biol Reprod 99(1):112\u2013126. https:\/\/doi.org\/10.1093\/biolre\/ioy021","journal-title":"Biol Reprod"},{"issue":"1","key":"4075_CR42","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a016634","volume":"7","author":"I Lam","year":"2014","unstructured":"Lam I, Keeney S (2014) Mechanism and regulation of meiotic recombination initiation. Cold Spring Harb Perspect Biol 7(1):a016634. https:\/\/doi.org\/10.1101\/cshperspect.a016634","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"4075_CR43","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1146\/annurev-genet-120215-035111","volume":"50","author":"S Gray","year":"2016","unstructured":"Gray S, Cohen PE (2016) Control of meiotic crossovers: from double-strand break formation to designation. Annu Rev Genet 50:175\u2013210. https:\/\/doi.org\/10.1146\/annurev-genet-120215-035111","journal-title":"Annu Rev Genet"},{"issue":"2","key":"4075_CR44","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1038\/nrg2723","volume":"11","author":"MA Handel","year":"2010","unstructured":"Handel MA, Schimenti JC (2010) Genetics of mammalian meiosis: regulation, dynamics and impact on fertility. Nat Rev Genet 11(2):124\u2013136. https:\/\/doi.org\/10.1038\/nrg2723","journal-title":"Nat Rev Genet"},{"issue":"12","key":"4075_CR45","doi-asserted-by":"publisher","first-page":"a016618","DOI":"10.1101\/cshperspect.a016618","volume":"7","author":"N Hunter","year":"2015","unstructured":"Hunter N (2015) Meiotic recombination: the essence of heredity. Cold Spring Harb Perspect Biol. 7(12):a016618. https:\/\/doi.org\/10.1101\/cshperspect.a016618","journal-title":"Cold Spring Harb Perspect Biol."},{"issue":"4","key":"4075_CR46","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1038\/ncb2451","volume":"14","author":"F Cole","year":"2012","unstructured":"Cole F, Kauppi L, Lange J, Roig I, Wang R, Keeney S, Jasin M (2012) Homeostatic control of recombination is implemented progressively in mouse meiosis. Nat Cell Biol 14(4):424\u2013430. https:\/\/doi.org\/10.1038\/ncb2451","journal-title":"Nat Cell Biol"},{"issue":"4","key":"4075_CR47","doi-asserted-by":"publisher","first-page":"255","DOI":"10.4161\/epi.5.4.11518","volume":"5","author":"A Inagaki","year":"2010","unstructured":"Inagaki A, Schoenmakers S, Baarends WM (2010) DNA double strand break repair, chromosome synapsis and transcriptional silencing in meiosis. Epigenetics 5(4):255\u2013266. https:\/\/doi.org\/10.4161\/epi.5.4.11518","journal-title":"Epigenetics"},{"issue":"5","key":"4075_CR48","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1083\/jcb.201311050","volume":"205","author":"TJ Broering","year":"2014","unstructured":"Broering TJ, Alavattam KG, Sadreyev RI, Ichijima Y, Kato Y, Hasegawa K, Camerini-Otero RD, Lee JT, Andreassen PR, Namekawa SH (2014) BRCA1 establishes DNA damage signaling and pericentric heterochromatin of the X chromosome in male meiosis. J Cell Biol 205(5):663\u2013675. https:\/\/doi.org\/10.1083\/jcb.201311050","journal-title":"J Cell Biol"},{"issue":"16","key":"4075_CR49","doi-asserted-by":"publisher","first-page":"7203","DOI":"10.1128\/MCB.25.16.7203-7215.2005","volume":"25","author":"M Barchi","year":"2005","unstructured":"Barchi M, Mahadevaiah S, Di Giacomo M, Baudat F, de Rooij DG, Burgoyne PS, Jasin M, Keeney S (2005) Surveillance of different recombination defects in mouse spermatocytes yields distinct responses despite elimination at an identical developmental stage. Mol Cell Biol 25(16):7203\u20137215. https:\/\/doi.org\/10.1128\/MCB.25.16.7203-7215.2005","journal-title":"Mol Cell Biol"},{"issue":"10","key":"4075_CR50","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a016675","volume":"6","author":"VV Subramanian","year":"2014","unstructured":"Subramanian VV, Hochwagen A (2014) The meiotic checkpoint network: step-by-step through meiotic prophase. Cold Spring Harb Perspect Biol 6(10):a016675. https:\/\/doi.org\/10.1101\/cshperspect.a016675","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"10","key":"4075_CR51","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1101\/gr.6520107","volume":"17","author":"D Homolka","year":"2007","unstructured":"Homolka D, Ivanek R, Capkova J, Jansa P, Forejt J (2007) Chromosomal rearrangement interferes with meiotic X chromosome inactivation. Genome Res 17(10):1431\u20131437. https:\/\/doi.org\/10.1101\/gr.6520107","journal-title":"Genome Res"},{"issue":"3","key":"4075_CR52","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1038\/ng0398-257","volume":"18","author":"T Odorisio","year":"1998","unstructured":"Odorisio T, Rodriguez TA, Evans EP, Clarke AR, Burgoyne PS (1998) The meiotic checkpoint monitoring synapsis eliminates spermatocytes via p53-independent apoptosis. Nat Genet 18(3):257\u2013261. https:\/\/doi.org\/10.1038\/ng0398-257","journal-title":"Nat Genet"},{"issue":"2","key":"4075_CR53","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1083\/jcb.200710195","volume":"182","author":"SK Mahadevaiah","year":"2008","unstructured":"Mahadevaiah SK, Bourc\u2019his D, de Rooij DG, Bestor TH, Turner JM, Burgoyne PS (2008) Extensive meiotic asynapsis in mice antagonises meiotic silencing of unsynapsed chromatin and consequently disrupts meiotic sex chromosome inactivation. J Cell Biol 182(2):263\u2013276. https:\/\/doi.org\/10.1083\/jcb.200710195","journal-title":"J Cell Biol"},{"issue":"10","key":"4075_CR54","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1002\/bies.20639","volume":"29","author":"PS Burgoyne","year":"2007","unstructured":"Burgoyne PS, Mahadevaiah SK, Turner JM (2007) The management of DNA double-strand breaks in mitotic G2, and in mammalian meiosis viewed from a mitotic G2 perspective. BioEssays 29(10):974\u2013986. https:\/\/doi.org\/10.1002\/bies.20639","journal-title":"BioEssays"},{"issue":"2","key":"4075_CR55","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.molcel.2010.09.019","volume":"40","author":"A Ciccia","year":"2010","unstructured":"Ciccia A, Elledge SJ (2010) The DNA damage response: making it safe to play with knives. Mol Cell 40(2):179\u2013204. https:\/\/doi.org\/10.1016\/j.molcel.2010.09.019","journal-title":"Mol Cell"},{"issue":"18","key":"4075_CR56","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2019101801","volume":"38","author":"MC Lanz","year":"2019","unstructured":"Lanz MC, Dibitetto D, Smolka MB (2019) DNA damage kinase signaling: checkpoint and repair at 30 years. Embo j 38(18):e101801. https:\/\/doi.org\/10.15252\/embj.2019101801","journal-title":"Embo j"},{"key":"4075_CR57","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1146\/annurev-genet-120213-092304","volume":"48","author":"S Keeney","year":"2014","unstructured":"Keeney S, Lange J, Mohibullah N (2014) Self-organization of meiotic recombination initiation: general principles and molecular pathways. Annu Rev Genet 48:187\u2013214. https:\/\/doi.org\/10.1146\/annurev-genet-120213-092304","journal-title":"Annu Rev Genet"},{"issue":"Pt 15","key":"4075_CR58","doi-asserted-by":"publisher","first-page":"3233","DOI":"10.1242\/jcs.02466","volume":"118","author":"MA Bellani","year":"2005","unstructured":"Bellani MA, Romanienko PJ, Cairatti DA, Camerini-Otero RD (2005) SPO11 is required for sex-body formation, and Spo11 heterozygosity rescues the prophase arrest of Atm-\/- spermatocytes. J Cell Sci 118(Pt 15):3233\u20133245. https:\/\/doi.org\/10.1242\/jcs.02466","journal-title":"J Cell Sci"},{"issue":"1","key":"4075_CR59","doi-asserted-by":"publisher","first-page":"2621","DOI":"10.1038\/s41467-018-04850-0","volume":"9","author":"A Widger","year":"2018","unstructured":"Widger A, Mahadevaiah SK, Lange J, ElInati E, Zohren J, Hirota T, Pacheco S, Maldonado-Linares A, Stanzione M, Ojarikre O, Maciulyte V, de Rooij DG, T\u00f3th A, Roig I, Keeney S, Turner JMA (2018) ATR is a multifunctional regulator of male mouse meiosis. Nat Commun 9(1):2621. https:\/\/doi.org\/10.1038\/s41467-018-04850-0","journal-title":"Nat Commun"},{"issue":"1","key":"4075_CR60","doi-asserted-by":"publisher","first-page":"2622","DOI":"10.1038\/s41467-018-04851-z","volume":"9","author":"S Pacheco","year":"2018","unstructured":"Pacheco S, Maldonado-Linares A, Marcet-Ortega M, Rojas C, Mart\u00ednez-Marchal A, Fuentes-Lazaro J, Lange J, Jasin M, Keeney S, Fern\u00e1ndez-Capetillo O, Garcia-Cald\u00e9s M, Roig I (2018) ATR is required to complete meiotic recombination in mice. Nat Commun 9(1):2622. https:\/\/doi.org\/10.1038\/s41467-018-04851-z","journal-title":"Nat Commun"},{"issue":"17","key":"4075_CR61","doi-asserted-by":"publisher","first-page":"2972","DOI":"10.1242\/dev.126078","volume":"142","author":"AM Fedoriw","year":"2015","unstructured":"Fedoriw AM, Menon D, Kim Y, Mu W, Magnuson T (2015) Key mediators of somatic ATR signaling localize to unpaired chromosomes in spermatocytes. Development 142(17):2972\u20132980. https:\/\/doi.org\/10.1242\/dev.126078","journal-title":"Development"},{"issue":"1","key":"4075_CR62","doi-asserted-by":"publisher","first-page":"5351","DOI":"10.1038\/s41467-018-07798-3","volume":"9","author":"D Menolfi","year":"2018","unstructured":"Menolfi D, Jiang W, Lee BJ, Moiseeva T, Shao Z, Estes V, Frattini MG, Bakkenist CJ, Zha S (2018) Kinase-dead ATR differs from ATR loss by limiting the dynamic exchange of ATR and RPA. Nat Commun 9(1):5351. https:\/\/doi.org\/10.1038\/s41467-018-07798-3","journal-title":"Nat Commun"},{"issue":"1","key":"4075_CR63","doi-asserted-by":"publisher","first-page":"4795","DOI":"10.1038\/s41467-019-12629-0","volume":"10","author":"SA Schalbetter","year":"2019","unstructured":"Schalbetter SA, Fudenberg G, Baxter J, Pollard KS, Neale MJ (2019) Principles of meiotic chromosome assembly revealed in S. cerevisiae. Nat Commun. 10(1):4795. https:\/\/doi.org\/10.1038\/s41467-019-12629-0","journal-title":"Nat Commun."},{"issue":"1","key":"4075_CR64","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1111\/gtc.12652","volume":"24","author":"KI Ishiguro","year":"2019","unstructured":"Ishiguro KI (2019) The cohesin complex in mammalian meiosis. Genes Cells 24(1):6\u201330. https:\/\/doi.org\/10.1111\/gtc.12652","journal-title":"Genes Cells"},{"key":"4075_CR65","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03193-z","author":"C Arnould","year":"2021","unstructured":"Arnould C, Rocher V, Finoux AL, Clouaire T, Li K, Zhou F, Caron P, Mangeot PE, Ricci EP, Mourad R, Haber JE, Noordermeer D, Legube G (2021) Loop extrusion as a mechanism for formation of DNA damage repair foci. Nature. https:\/\/doi.org\/10.1038\/s41586-021-03193-z","journal-title":"Nature"},{"issue":"23","key":"4075_CR66","doi-asserted-by":"publisher","first-page":"2117","DOI":"10.1016\/j.cub.2010.11.010","volume":"20","author":"H Royo","year":"2010","unstructured":"Royo H, Polikiewicz G, Mahadevaiah SK, Prosser H, Mitchell M, Bradley A, de Rooij DG, Burgoyne PS, Turner JM (2010) Evidence that meiotic sex chromosome inactivation is essential for male fertility. Curr Biol 20(23):2117\u20132123. https:\/\/doi.org\/10.1016\/j.cub.2010.11.010","journal-title":"Curr Biol"},{"issue":"6","key":"4075_CR67","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004444","volume":"10","author":"N Vernet","year":"2014","unstructured":"Vernet N, Mahadevaiah SK, Yamauchi Y, Decarpentrie F, Mitchell MJ, Ward MA, Burgoyne PS (2014) Mouse Y-linked Zfy1 and Zfy2 are expressed during the male-specific interphase between meiosis I and meiosis II and promote the 2nd meiotic division. PLoS Genet 10(6):e1004444. https:\/\/doi.org\/10.1371\/journal.pgen.1004444","journal-title":"PLoS Genet"},{"issue":"24","key":"4075_CR68","doi-asserted-by":"publisher","first-page":"5300","DOI":"10.1093\/hmg\/ddw344","volume":"25","author":"N Vernet","year":"2016","unstructured":"Vernet N, Mahadevaiah SK, de Rooij DG, Burgoyne PS, Ellis PJI (2016) Zfy genes are required for efficient meiotic sex chromosome inactivation (MSCI) in spermatocytes. Hum Mol Genet 25(24):5300\u20135310. https:\/\/doi.org\/10.1093\/hmg\/ddw344","journal-title":"Hum Mol Genet"},{"issue":"1","key":"4075_CR69","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1006578","volume":"13","author":"T Nakasuji","year":"2017","unstructured":"Nakasuji T, Ogonuki N, Chiba T, Kato T, Shiozawa K, Yamatoya K, Tanaka H, Kondo T, Miyado K, Miyasaka N, Kubota T, Ogura A, Asahara H (2017) Complementary critical functions of Zfy1 and Zfy2 in mouse spermatogenesis and reproduction. PLoS Genet 13(1):e1006578. https:\/\/doi.org\/10.1371\/journal.pgen.1006578","journal-title":"PLoS Genet"},{"issue":"7","key":"4075_CR70","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1007\/s00412-004-0277-5","volume":"112","author":"K Reini","year":"2004","unstructured":"Reini K, Uitto L, Perera D, Moens PB, Freire R, Syvaoja JE (2004) TopBP1 localises to centrosomes in mitosis and to chromosome cores in meiosis. Chromosoma 112(7):323\u2013330. https:\/\/doi.org\/10.1007\/s00412-004-0277-5","journal-title":"Chromosoma"},{"issue":"Pt 14","key":"4075_CR71","doi-asserted-by":"publisher","first-page":"2488","DOI":"10.1242\/jcs.081711","volume":"124","author":"E Refolio","year":"2011","unstructured":"Refolio E, Cavero S, Marcon E, Freire R, San-Segundo PA (2011) The Ddc2\/ATRIP checkpoint protein monitors meiotic recombination intermediates. J Cell Sci 124(Pt 14):2488\u20132500. https:\/\/doi.org\/10.1242\/jcs.081711","journal-title":"J Cell Sci"},{"issue":"2","key":"4075_CR72","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/s0092-8674(00)81847-4","volume":"88","author":"R Scully","year":"1997","unstructured":"Scully R, Chen J, Plug A, Xiao Y, Weaver D, Feunteun J, Ashley T, Livingston DM (1997) Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell 88(2):265\u2013275. https:\/\/doi.org\/10.1016\/s0092-8674(00)81847-4","journal-title":"Cell"},{"issue":"23","key":"4075_CR73","doi-asserted-by":"publisher","first-page":"2135","DOI":"10.1016\/j.cub.2004.11.032","volume":"14","author":"JM Turner","year":"2004","unstructured":"Turner JM, Aprelikova O, Xu X, Wang R, Kim S, Chandramouli GV, Barrett JC, Burgoyne PS, Deng CX (2004) BRCA1, histone H2AX phosphorylation, and male meiotic sex chromosome inactivation. Curr Biol 14(23):2135\u20132142. https:\/\/doi.org\/10.1016\/j.cub.2004.11.032","journal-title":"Curr Biol"},{"issue":"3","key":"4075_CR74","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/s0092-8674(00)80503-6","volume":"90","author":"R Scully","year":"1997","unstructured":"Scully R, Chen J, Ochs RL, Keegan K, Hoekstra M, Feunteun J, Livingston DM (1997) Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage. Cell 90(3):425\u2013435. https:\/\/doi.org\/10.1016\/s0092-8674(00)80503-6","journal-title":"Cell"},{"issue":"2","key":"4075_CR75","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1038\/nrm2831","volume":"11","author":"MS Huen","year":"2010","unstructured":"Huen MS, Sy SM, Chen J (2010) BRCA1 and its toolbox for the maintenance of genome integrity. Nat Rev Mol Cell Biol 11(2):138\u2013148. https:\/\/doi.org\/10.1038\/nrm2831","journal-title":"Nat Rev Mol Cell Biol"},{"key":"4075_CR76","doi-asserted-by":"publisher","first-page":"2105","DOI":"10.1038\/ncomms3105","volume":"4","author":"LY Lu","year":"2013","unstructured":"Lu LY, Xiong Y, Kuang H, Korakavi G, Yu X (2013) Regulation of the DNA damage response on male meiotic sex chromosomes. Nat Commun 4:2105. https:\/\/doi.org\/10.1038\/ncomms3105","journal-title":"Nat Commun"},{"issue":"4","key":"4075_CR77","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1080\/15384101.2014.998070","volume":"14","author":"LY Lu","year":"2015","unstructured":"Lu LY, Yu X (2015) Double-strand break repair on sex chromosomes: challenges during male meiotic prophase. Cell Cycle 14(4):516\u2013525. https:\/\/doi.org\/10.1080\/15384101.2014.998070","journal-title":"Cell Cycle"},{"issue":"Pt 14","key":"4075_CR78","doi-asserted-by":"publisher","first-page":"2446","DOI":"10.1242\/jcs.049353","volume":"122","author":"A Kouznetsova","year":"2009","unstructured":"Kouznetsova A, Wang H, Bellani M, Camerini-Otero RD, Jessberger R, H\u00f6\u00f6g C (2009) BRCA1-mediated chromatin silencing is limited to oocytes with a small number of asynapsed chromosomes. J Cell Sci 122(Pt 14):2446\u20132452. https:\/\/doi.org\/10.1242\/jcs.049353","journal-title":"J Cell Sci"},{"issue":"12","key":"4075_CR79","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003985","volume":"9","author":"U Biswas","year":"2013","unstructured":"Biswas U, Wetzker C, Lange J, Christodoulou EG, Seifert M, Beyer A, Jessberger R (2013) Meiotic cohesin SMC1\u03b2 provides prophase I centromeric cohesion and is required for multiple synapsis-associated functions. PLoS Genet 9(12):e1003985. https:\/\/doi.org\/10.1371\/journal.pgen.1003985","journal-title":"PLoS Genet"},{"issue":"11","key":"4075_CR80","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1001190","volume":"6","author":"YH Shin","year":"2010","unstructured":"Shin YH, Choi Y, Erdin SU, Yatsenko SA, Kloc M, Yang F, Wang PJ, Meistrich ML, Rajkovic A (2010) Hormad1 mutation disrupts synaptonemal complex formation, recombination, and chromosome segregation in mammalian meiosis. PLoS Genet 6(11):e1001190. https:\/\/doi.org\/10.1371\/journal.pgen.1001190","journal-title":"PLoS Genet"},{"issue":"5","key":"4075_CR81","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1038\/ncb2213","volume":"13","author":"K Daniel","year":"2011","unstructured":"Daniel K, Lange J, Hached K, Fu J, Anastassiadis K, Roig I, Cooke HJ, Stewart AF, Wassmann K, Jasin M, Keeney S, T\u00f3th A (2011) Meiotic homologue alignment and its quality surveillance are controlled by mouse HORMAD1. Nat Cell Biol 13(5):599\u2013610. https:\/\/doi.org\/10.1038\/ncb2213","journal-title":"Nat Cell Biol"},{"issue":"6","key":"4075_CR82","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1111\/j.1365-2443.2012.01600.x","volume":"17","author":"H Kogo","year":"2012","unstructured":"Kogo H, Tsutsumi M, Ohye T, Inagaki H, Abe T, Kurahashi H (2012) HORMAD1-dependent checkpoint\/surveillance mechanism eliminates asynaptic oocytes. Genes Cells 17(6):439\u2013454. https:\/\/doi.org\/10.1111\/j.1365-2443.2012.01600.x","journal-title":"Genes Cells"},{"issue":"9","key":"4075_CR83","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1101\/gad.187559.112","volume":"26","author":"L Wojtasz","year":"2012","unstructured":"Wojtasz L, Cloutier JM, Baumann M, Daniel K, Varga J, Fu J, Anastassiadis K, Stewart AF, Rem\u00e9nyi A, Turner JM, T\u00f3th A (2012) Meiotic DNA double-strand breaks and chromosome asynapsis in mice are monitored by distinct HORMAD2-independent and -dependent mechanisms. Genes Dev 26(9):958\u2013973. https:\/\/doi.org\/10.1101\/gad.187559.112","journal-title":"Genes Dev"},{"issue":"11","key":"4075_CR84","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1111\/gtc.12005","volume":"17","author":"H Kogo","year":"2012","unstructured":"Kogo H, Tsutsumi M, Inagaki H, Ohye T, Kiyonari H, Kurahashi H (2012) HORMAD2 is essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Genes Cells 17(11):897\u2013912. https:\/\/doi.org\/10.1111\/gtc.12005","journal-title":"Genes Cells"},{"issue":"2","key":"4075_CR85","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002485","volume":"8","author":"T Fukuda","year":"2012","unstructured":"Fukuda T, Pratto F, Schimenti JC, Turner JM, Camerini-Otero RD, H\u00f6\u00f6g C (2012) Phosphorylation of chromosome core components may serve as axis marks for the status of chromosomal events during mammalian meiosis. PLoS Genet 8(2):e1002485. https:\/\/doi.org\/10.1371\/journal.pgen.1002485","journal-title":"PLoS Genet"},{"issue":"19","key":"4075_CR86","doi-asserted-by":"publisher","first-page":"3135","DOI":"10.4161\/cc.26061","volume":"12","author":"AM Lyndaker","year":"2013","unstructured":"Lyndaker AM, Vasileva A, Wolgemuth DJ, Weiss RS, Lieberman HB (2013) Clamping down on mammalian meiosis. Cell Cycle 12(19):3135\u20133145. https:\/\/doi.org\/10.4161\/cc.26061","journal-title":"Cell Cycle"},{"issue":"7","key":"4075_CR87","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1002\/em.22401","volume":"61","author":"C Pereira","year":"2020","unstructured":"Pereira C, Smolka MB, Weiss RS, Brie\u00f1o-Enr\u00edquez MA (2020) ATR signaling in mammalian meiosis: from upstream scaffolds to downstream signaling. Environ Mol Mutagen 61(7):752\u2013766. https:\/\/doi.org\/10.1002\/em.22401","journal-title":"Environ Mol Mutagen"},{"issue":"2","key":"4075_CR88","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007952","volume":"15","author":"B Shi","year":"2019","unstructured":"Shi B, Xue J, Yin H, Guo R, Luo M, Ye L, Shi Q, Huang X, Liu M, Sha J, Wang PJ (2019) Dual functions for the ssDNA-binding protein RPA in meiotic recombination. PLoS Genet 15(2):e1007952. https:\/\/doi.org\/10.1371\/journal.pgen.1007952","journal-title":"PLoS Genet"},{"issue":"Pt 17","key":"4075_CR89","doi-asserted-by":"publisher","first-page":"3927","DOI":"10.1242\/jcs.126763","volume":"126","author":"A Vasileva","year":"2013","unstructured":"Vasileva A, Hopkins KM, Wang X, Weisbach MM, Friedman RA, Wolgemuth DJ, Lieberman HB (2013) The DNA damage checkpoint protein RAD9A is essential for male meiosis in the mouse. J Cell Sci 126(Pt 17):3927\u20133938. https:\/\/doi.org\/10.1242\/jcs.126763","journal-title":"J Cell Sci"},{"issue":"2","key":"4075_CR90","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003320","volume":"9","author":"AM Lyndaker","year":"2013","unstructured":"Lyndaker AM, Lim PX, Mleczko JM, Diggins CE, Holloway JK, Holmes RJ, Kan R, Schlafer DH, Freire R, Cohen PE, Weiss RS (2013) Conditional inactivation of the DNA damage response gene Hus1 in mouse testis reveals separable roles for components of the RAD9-RAD1-HUS1 complex in meiotic chromosome maintenance. PLoS Genet 9(2):e1003320. https:\/\/doi.org\/10.1371\/journal.pgen.1003320","journal-title":"PLoS Genet"},{"issue":"5","key":"4075_CR91","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/nrm.2017.7","volume":"18","author":"SF Banani","year":"2017","unstructured":"Banani SF, Lee HO, Hyman AA, Rosen MK (2017) Biomolecular condensates: organizers of cellular biochemistry. Nat Rev Mol Cell Biol 18(5):285\u2013298. https:\/\/doi.org\/10.1038\/nrm.2017.7","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"5","key":"4075_CR92","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1016\/j.cell.2016.05.026","volume":"165","author":"LP Bergeron-Sandoval","year":"2016","unstructured":"Bergeron-Sandoval LP, Safaee N, Michnick SW (2016) Mechanisms and consequences of macromolecular phase separation. Cell 165(5):1067\u20131079. https:\/\/doi.org\/10.1016\/j.cell.2016.05.026","journal-title":"Cell"},{"issue":"2","key":"4075_CR93","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/j.cell.2019.08.037","volume":"179","author":"BA Gibson","year":"2019","unstructured":"Gibson BA, Doolittle LK, Schneider MWG, Jensen LE, Gamarra N, Henry L, Gerlich DW, Redding S, Rosen MK (2019) Organization of chromatin by intrinsic and regulated phase separation. Cell 179(2):470-484.e421. https:\/\/doi.org\/10.1016\/j.cell.2019.08.037","journal-title":"Cell"},{"issue":"7","key":"4075_CR94","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1016\/j.cub.2006.01.066","volume":"16","author":"SH Namekawa","year":"2006","unstructured":"Namekawa SH, Park PJ, Zhang LF, Shima JE, McCarrey JR, Griswold MD, Lee JT (2006) Postmeiotic sex chromatin in the male germline of mice. Curr Biol 16(7):660\u2013667. https:\/\/doi.org\/10.1016\/j.cub.2006.01.066","journal-title":"Curr Biol"},{"key":"4075_CR95","doi-asserted-by":"publisher","first-page":"8088","DOI":"10.1038\/ncomms9088","volume":"6","author":"M Altmeyer","year":"2015","unstructured":"Altmeyer M, Neelsen KJ, Teloni F, Pozdnyakova I, Pellegrino S, Grofte M, Rask MD, Streicher W, Jungmichel S, Nielsen ML, Lukas J (2015) Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose). Nat Commun 6:8088. https:\/\/doi.org\/10.1038\/ncomms9088","journal-title":"Nat Commun"},{"issue":"5","key":"4075_CR96","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1016\/j.cell.2015.07.047","volume":"162","author":"A Patel","year":"2015","unstructured":"Patel A, Lee HO, Jawerth L, Maharana S, Jahnel M, Hein MY, Stoynov S, Mahamid J, Saha S, Franzmann TM, Pozniakovski A, Poser I, Maghelli N, Royer LA, Weigert M, Myers EW, Grill S, Drechsel D, Hyman AA, Alberti S (2015) A liquid-to-solid phase transition of the ALS protein FUS accelerated by disease mutation. Cell 162(5):1066\u20131077. https:\/\/doi.org\/10.1016\/j.cell.2015.07.047","journal-title":"Cell"},{"issue":"40","key":"4075_CR97","doi-asserted-by":"publisher","first-page":"14854","DOI":"10.1073\/pnas.0604252103","volume":"103","author":"F Dantzer","year":"2006","unstructured":"Dantzer F, Mark M, Quenet D, Scherthan H, Huber A, Liebe B, Monaco L, Chicheportiche A, Sassone-Corsi P, de Murcia G, M\u00e9nissier-de Murcia J (2006) Poly(ADP-ribose) polymerase-2 contributes to the fidelity of male meiosis I and spermiogenesis. Proc Natl Acad Sci U S A 103(40):14854\u201314859. https:\/\/doi.org\/10.1073\/pnas.0604252103","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"16","key":"4075_CR98","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2018101379","volume":"38","author":"S Kilic","year":"2019","unstructured":"Kilic S, Lezaja A, Gatti M, Bianco E, Michelena J, Imhof R, Altmeyer M (2019) Phase separation of 53BP1 determines liquid-like behavior of DNA repair compartments. Embo j 38(16):e101379. https:\/\/doi.org\/10.15252\/embj.2018101379","journal-title":"Embo j"},{"issue":"9","key":"4075_CR99","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1016\/j.dnarep.2007.02.011","volume":"6","author":"EA Ahmed","year":"2007","unstructured":"Ahmed EA, van der Vaart A, Barten A, Kal HB, Chen J, Lou Z, Minter-Dykhouse K, Bartkova J, Bartek J, de Boer P, de Rooij DG (2007) Differences in DNA double strand breaks repair in male germ cell types: lessons learned from a differential expression of Mdc1 and 53BP1. DNA Repair (Amst) 6(9):1243\u20131254. https:\/\/doi.org\/10.1016\/j.dnarep.2007.02.011","journal-title":"DNA Repair (Amst)"},{"issue":"3","key":"4075_CR100","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/j.cell.2016.06.010","volume":"166","author":"SF Banani","year":"2016","unstructured":"Banani SF, Rice AM, Peeples WB, Lin Y, Jain S, Parker R, Rosen MK (2016) Compositional control of phase-separated cellular bodies. Cell 166(3):651\u2013663. https:\/\/doi.org\/10.1016\/j.cell.2016.06.010","journal-title":"Cell"},{"issue":"5","key":"4075_CR101","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1007\/s00412-004-0311-7","volume":"113","author":"RS Rogers","year":"2004","unstructured":"Rogers RS, Inselman A, Handel MA, Matunis MJ (2004) SUMO modified proteins localize to the XY body of pachytene spermatocytes. Chromosoma 113(5):233\u2013243. https:\/\/doi.org\/10.1007\/s00412-004-0311-7","journal-title":"Chromosoma"},{"issue":"1","key":"4075_CR102","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s10577-008-9006-x","volume":"17","author":"M Vigodner","year":"2009","unstructured":"Vigodner M (2009) Sumoylation precedes accumulation of phosphorylated H2AX on sex chromosomes during their meiotic inactivation. Chromosome Res 17(1):37\u201345. https:\/\/doi.org\/10.1007\/s10577-008-9006-x","journal-title":"Chromosome Res"},{"issue":"6","key":"4075_CR103","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003538","volume":"9","author":"F Carofiglio","year":"2013","unstructured":"Carofiglio F, Inagaki A, de Vries S, Wassenaar E, Schoenmakers S, Vermeulen C, van Cappellen WA, Sleddens-Linkels E, Grootegoed JA, Te Riele HP, de Massy B, Baarends WM (2013) SPO11-independent DNA repair foci and their role in meiotic silencing. PLoS Genet 9(6):e1003538. https:\/\/doi.org\/10.1371\/journal.pgen.1003538","journal-title":"PLoS Genet"},{"issue":"4","key":"4075_CR104","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.devcel.2006.02.009","volume":"10","author":"JM Turner","year":"2006","unstructured":"Turner JM, Mahadevaiah SK, Ellis PJ, Mitchell MJ, Burgoyne PS (2006) Pachytene asynapsis drives meiotic sex chromosome inactivation and leads to substantial postmeiotic repression in spermatids. Dev Cell 10(4):521\u2013529. https:\/\/doi.org\/10.1016\/j.devcel.2006.02.009","journal-title":"Dev Cell"},{"issue":"8","key":"4075_CR105","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000625","volume":"5","author":"M Manterola","year":"2009","unstructured":"Manterola M, Page J, Vasco C, Berr\u00edos S, Parra MT, Viera A, Rufas JS, Zuccotti M, Garagna S, Fern\u00e1ndez-Donoso R (2009) A high incidence of meiotic silencing of unsynapsed chromatin is not associated with substantial pachytene loss in heterozygous male mice carrying multiple simple robertsonian translocations. PLoS Genet 5(8):e1000625. https:\/\/doi.org\/10.1371\/journal.pgen.1000625","journal-title":"PLoS Genet"},{"key":"4075_CR106","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1146\/annurev-cellbio-100913-013325","volume":"30","author":"AA Hyman","year":"2014","unstructured":"Hyman AA, Weber CA, J\u00fclicher F (2014) Liquid-liquid phase separation in biology. Annu Rev Cell Dev Biol 30:39\u201358. https:\/\/doi.org\/10.1146\/annurev-cellbio-100913-013325","journal-title":"Annu Rev Cell Dev Biol"},{"issue":"3","key":"4075_CR107","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1042\/etls20190164","volume":"4","author":"EW Martin","year":"2020","unstructured":"Martin EW, Holehouse AS (2020) Intrinsically disordered protein regions and phase separation: sequence determinants of assembly or lack thereof. Emerg Top Life Sci 4(3):307\u2013329. https:\/\/doi.org\/10.1042\/etls20190164","journal-title":"Emerg Top Life Sci"},{"key":"4075_CR108","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12964-015-0125-7","volume":"14","author":"DM Mitrea","year":"2016","unstructured":"Mitrea DM, Kriwacki RW (2016) Phase separation in biology; functional organization of a higher order. Cell Commun Signal 14:1. https:\/\/doi.org\/10.1186\/s12964-015-0125-7","journal-title":"Cell Commun Signal"},{"issue":"12","key":"4075_CR109","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1038\/s41576-018-0060-8","volume":"19","author":"MJ Rowley","year":"2018","unstructured":"Rowley MJ, Corces VG (2018) Organizational principles of 3D genome architecture. Nat Rev Genet 19(12):789\u2013800. https:\/\/doi.org\/10.1038\/s41576-018-0060-8","journal-title":"Nat Rev Genet"},{"issue":"2","key":"4075_CR110","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/j.cell.2018.05.007","volume":"174","author":"CY Wang","year":"2018","unstructured":"Wang CY, Jegu T, Chu HP, Oh HJ, Lee JT (2018) SMCHD1 merges chromosome compartments and assists formation of super-structures on the inactive X. Cell. 174(2):406\u2013421. https:\/\/doi.org\/10.1016\/j.cell.2018.05.007","journal-title":"Cell."},{"issue":"5","key":"4075_CR111","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1038\/s41594-019-0223-0","volume":"26","author":"A Cerase","year":"2019","unstructured":"Cerase A, Armaos A, Neumayer C, Avner P, Guttman M, Tartaglia GG (2019) Phase separation drives X-chromosome inactivation: a hypothesis. Nat Struct Mol Biol 26(5):331\u2013334. https:\/\/doi.org\/10.1038\/s41594-019-0223-0","journal-title":"Nat Struct Mol Biol"},{"key":"4075_CR112","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1186\/s13059-015-0728-8","volume":"16","author":"X Deng","year":"2015","unstructured":"Deng X, Ma W, Ramani V, Hill A, Yang F, Ay F, Berletch JB, Blau CA, Shendure J, Duan Z, Noble WS, Disteche CM (2015) Bipartite structure of the inactive mouse X chromosome. Genome Biol 16:152. https:\/\/doi.org\/10.1186\/s13059-015-0728-8","journal-title":"Genome Biol"},{"issue":"7613","key":"4075_CR113","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1038\/nature18589","volume":"535","author":"L Giorgetti","year":"2016","unstructured":"Giorgetti L, Lajoie BR, Carter AC, Attia M, Zhan Y, Xu J, Chen CJ, Kaplan N, Chang HY, Heard E, Dekker J (2016) Structural organization of the inactive X chromosome in the mouse. Nature 535(7613):575\u2013579. https:\/\/doi.org\/10.1038\/nature18589","journal-title":"Nature"},{"issue":"6245","key":"4075_CR114","doi-asserted-by":"publisher","first-page":"aab2276","DOI":"10.1126\/science.aab2276","volume":"349","author":"A Minajigi","year":"2015","unstructured":"Minajigi A, Froberg J, Wei C, Sunwoo H, Kesner B, Colognori D, Lessing D, Payer B, Boukhali M, Haas W, Lee JT (2015) Chromosomes A comprehensive Xist interactome reveals cohesin repulsion and an RNA-directed chromosome conformation. Science. 349(6245):aab2276. https:\/\/doi.org\/10.1126\/science.aab2276","journal-title":"Science."},{"issue":"7","key":"4075_CR115","doi-asserted-by":"publisher","first-page":"1665","DOI":"10.1016\/j.cell.2014.11.021","volume":"159","author":"SS Rao","year":"2014","unstructured":"Rao SS, Huntley MH, Durand NC, Stamenova EK, Bochkov ID, Robinson JT, Sanborn AL, Machol I, Omer AD, Lander ES, Aiden EL (2014) A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping. Cell 159(7):1665\u20131680. https:\/\/doi.org\/10.1016\/j.cell.2014.11.021","journal-title":"Cell"},{"key":"4075_CR116","unstructured":"Alavattam KG (2019) Epigenetic regulation of the sex chromosomes and 3D chromatin organization in male germ cells. Dissertation, University of Cincinnati College of Medicine"},{"issue":"14","key":"4075_CR117","doi-asserted-by":"publisher","first-page":"5394","DOI":"10.1128\/mcb.00519-06","volume":"26","author":"IK Greaves","year":"2006","unstructured":"Greaves IK, Rangasamy D, Devoy M, Marshall Graves JA, Tremethick DJ (2006) The X and Y chromosomes assemble into H2A Z-containing [corrected] facultative heterochromatin [corrected] following meiosis. Mol Cell Biol. 26(14):5394\u20135405. https:\/\/doi.org\/10.1128\/mcb.00519-06","journal-title":"Mol Cell Biol."},{"issue":"23","key":"4075_CR118","doi-asserted-by":"publisher","first-page":"9730","DOI":"10.1073\/pnas.0700323104","volume":"104","author":"SH Namekawa","year":"2007","unstructured":"Namekawa SH, VandeBerg JL, McCarrey JR, Lee JT (2007) Sex chromosome silencing in the marsupial male germ line. Proc Natl Acad Sci U S A 104(23):9730\u20139735. https:\/\/doi.org\/10.1073\/pnas.0700323104","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"11","key":"4075_CR119","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1002\/dvg.20345","volume":"45","author":"JL Hornecker","year":"2007","unstructured":"Hornecker JL, Samollow PB, Robinson ES, Vandeberg JL, McCarrey JR (2007) Meiotic sex chromosome inactivation in the marsupial Monodelphis domestica. Genesis 45(11):696\u2013708. https:\/\/doi.org\/10.1002\/dvg.20345","journal-title":"Genesis"},{"issue":"5","key":"4075_CR120","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1101\/gr.135046.111","volume":"22","author":"HS Sin","year":"2012","unstructured":"Sin HS, Ichijima Y, Koh E, Namiki M, Namekawa SH (2012) Human postmeiotic sex chromatin and its impact on sex chromosome evolution. Genome Res 22(5):827\u2013836. https:\/\/doi.org\/10.1101\/gr.135046.111","journal-title":"Genome Res"},{"issue":"2","key":"4075_CR121","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031485","volume":"7","author":"M de Vries","year":"2012","unstructured":"de Vries M, Vosters S, Merkx G, D\u2019Hauwers K, Wansink DG, Ramos L, de Boer P (2012) Human male meiotic sex chromosome inactivation. PLoS One 7(2):e31485. https:\/\/doi.org\/10.1371\/journal.pone.0031485","journal-title":"PLoS One"},{"issue":"9","key":"4075_CR122","doi-asserted-by":"publisher","first-page":"887","DOI":"10.4161\/epi.25672","volume":"8","author":"HS Sin","year":"2013","unstructured":"Sin HS, Namekawa SH (2013) The great escape: active genes on inactive sex chromosomes and their evolutionary implications. Epigenetics 8(9):887\u2013892. https:\/\/doi.org\/10.4161\/epi.25672","journal-title":"Epigenetics"},{"issue":"2","key":"4075_CR123","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1093\/nar\/gkx1052","volume":"46","author":"S Maezawa","year":"2018","unstructured":"Maezawa S, Yukawa M, Alavattam KG, Barski A, Namekawa SH (2018) Dynamic reorganization of open chromatin underlies diverse transcriptomes during spermatogenesis. Nucleic Acids Res 46(2):593\u2013608. https:\/\/doi.org\/10.1093\/nar\/gkx1052","journal-title":"Nucleic Acids Res"},{"issue":"10","key":"4075_CR124","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1038\/s41594-020-0487-4","volume":"27","author":"A Sakashita","year":"2020","unstructured":"Sakashita A, Maezawa S, Takahashi K, Alavattam KG, Yukawa M, Hu YC, Kojima S, Parrish NF, Barski A, Pavlicev M, Namekawa SH (2020) Endogenous retroviruses drive species-specific germline transcriptomes in mammals. Nat Struct Mol Biol 27(10):967\u2013977. https:\/\/doi.org\/10.1038\/s41594-020-0487-4","journal-title":"Nat Struct Mol Biol"},{"issue":"10","key":"4075_CR125","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1038\/s41594-020-0488-3","volume":"27","author":"S Maezawa","year":"2020","unstructured":"Maezawa S, Sakashita A, Yukawa M, Chen X, Takahashi K, Alavattam KG, Nakata I, Weirauch MT, Barski A, Namekawa SH (2020) Super-enhancer switching drives a burst in gene expression at the mitosis-to-meiosis transition. Nat Struct Mol Biol 27(10):978\u2013988. https:\/\/doi.org\/10.1038\/s41594-020-0488-3","journal-title":"Nat Struct Mol Biol"},{"issue":"1","key":"4075_CR126","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1038\/s41467-019-09182-1","volume":"10","author":"C Ernst","year":"2019","unstructured":"Ernst C, Eling N, Martinez-Jimenez CP, Marioni JC, Odom DT (2019) Staged developmental mapping and X chromosome transcriptional dynamics during mouse spermatogenesis. Nat Commun 10(1):1251. https:\/\/doi.org\/10.1038\/s41467-019-09182-1","journal-title":"Nat Commun"},{"issue":"5","key":"4075_CR127","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/j.devcel.2018.10.004","volume":"47","author":"T Hirota","year":"2018","unstructured":"Hirota T, Blakeley P, Sangrithi MN, Mahadevaiah SK, Encheva V, Snijders AP, ElInati E, Ojarikre OA, de Rooij DG, Niakan KK, Turner JMA (2018) SETDB1 links the meiotic DNA damage response to sex chromosome silencing in mice. Dev Cell 47(5):645-659.e646. https:\/\/doi.org\/10.1016\/j.devcel.2018.10.004","journal-title":"Dev Cell"},{"issue":"4","key":"4075_CR128","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003435","volume":"9","author":"OJ Becherel","year":"2013","unstructured":"Becherel OJ, Yeo AJ, Stellati A, Heng EY, Luff J, Suraweera AM, Woods R, Fleming J, Carrie D, McKinney K, Xu X, Deng C, Lavin MF (2013) Senataxin plays an essential role with DNA damage response proteins in meiotic recombination and gene silencing. PLoS Genet 9(4):e1003435. https:\/\/doi.org\/10.1371\/journal.pgen.1003435","journal-title":"PLoS Genet"},{"issue":"2","key":"4075_CR129","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.devcel.2012.07.003","volume":"23","author":"AJ Modzelewski","year":"2012","unstructured":"Modzelewski AJ, Holmes RJ, Hilz S, Grimson A, Cohen PE (2012) AGO4 regulates entry into meiosis and influences silencing of sex chromosomes in the male mouse germline. Dev Cell 23(2):251\u2013264. https:\/\/doi.org\/10.1016\/j.devcel.2012.07.003","journal-title":"Dev Cell"},{"issue":"1","key":"4075_CR130","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004954","volume":"11","author":"M Luo","year":"2015","unstructured":"Luo M, Zhou J, Leu NA, Abreu CM, Wang J, Anguera MC, de Rooij DG, Jasin M, Wang PJ (2015) Polycomb protein SCML2 associates with USP7 and counteracts histone H2A ubiquitination in the XY chromatin during male meiosis. PLoS Genet 11(1):e1004954. https:\/\/doi.org\/10.1371\/journal.pgen.1004954","journal-title":"PLoS Genet"},{"issue":"8","key":"4075_CR131","doi-asserted-by":"publisher","first-page":"2025421118","DOI":"10.1073\/pnas.2025421118","volume":"118","author":"M Li","year":"2021","unstructured":"Li M, Zheng J, Li G, Lin Z, Li D, Liu D, Feng H, Cao D, Ng EHY, Li RHW, Han C, Yeung WSB, Chow LT, Wang H, Liu K (2021) The male germline-specific protein MAPS is indispensable for pachynema progression and fertility. Proc Natl Acad Sci USA. 118(8):2025421118. https:\/\/doi.org\/10.1073\/pnas.2025421118","journal-title":"Proc Natl Acad Sci USA."},{"issue":"2","key":"4075_CR132","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1038\/ng1949","volume":"39","author":"GW van der Heijden","year":"2007","unstructured":"van der Heijden GW, Derijck AA, Posfai E, Giele M, Pelczar P, Ramos L, Wansink DG, van der Vlag J, Peters AH, de Boer P (2007) Chromosome-wide nucleosome replacement and H3.3 incorporation during mammalian meiotic sex chromosome inactivation. Nat Genet 39(2):251\u2013258. https:\/\/doi.org\/10.1038\/ng1949","journal-title":"Nat Genet"},{"issue":"3","key":"4075_CR133","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/j.celrep.2016.12.065","volume":"18","author":"J Ueda","year":"2017","unstructured":"Ueda J, Harada A, Urahama T, Machida S, Maehara K, Hada M, Makino Y, Nogami J, Horikoshi N, Osakabe A, Taguchi H, Tanaka H, Tachiwana H, Yao T, Yamada M, Iwamoto T, Isotani A, Ikawa M, Tachibana T, Okada Y, Kimura H, Ohkawa Y, Kurumizaka H, Yamagata K (2017) Testis-specific histone variant H3t gene is essential for entry into spermatogenesis. Cell Rep 18(3):593\u2013600. https:\/\/doi.org\/10.1016\/j.celrep.2016.12.065","journal-title":"Cell Rep"},{"issue":"3","key":"4075_CR134","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.tig.2018.12.007","volume":"35","author":"V Tsui","year":"2019","unstructured":"Tsui V, Crismani W (2019) The fanconi anemia pathway and fertility. Trends Genet 35(3):199\u2013214. https:\/\/doi.org\/10.1016\/j.tig.2018.12.007","journal-title":"Trends Genet"},{"issue":"18","key":"4075_CR135","doi-asserted-by":"publisher","first-page":"5234","DOI":"10.1093\/hmg\/ddv244","volume":"24","author":"Y Kato","year":"2015","unstructured":"Kato Y, Alavattam KG, Sin HS, Meetei AR, Pang Q, Andreassen PR, Namekawa SH (2015) FANCB is essential in the male germline and regulates H3K9 methylation on the sex chromosomes during meiosis. Hum Mol Genet 24(18):5234\u20135249. https:\/\/doi.org\/10.1093\/hmg\/ddv244","journal-title":"Hum Mol Genet"},{"issue":"6","key":"4075_CR136","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002094","volume":"7","author":"JK Holloway","year":"2011","unstructured":"Holloway JK, Mohan S, Balmus G, Sun X, Modzelewski A, Borst PL, Freire R, Weiss RS, Cohen PE (2011) Mammalian BTBD12 (SLX4) protects against genomic instability during mammalian spermatogenesis. PLoS Genet 7(6):e1002094. https:\/\/doi.org\/10.1371\/journal.pgen.1002094","journal-title":"PLoS Genet"},{"issue":"8","key":"4075_CR137","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1038\/s41419-021-04034-7","volume":"12","author":"L Xu","year":"2021","unstructured":"Xu L, Xu W, Li D, Yu X, Gao F, Qin Y, Yang Y, Zhao S (2021) FANCI plays an essential role in spermatogenesis and regulates meiotic histone methylation. Cell Death Dis 12(8):780. https:\/\/doi.org\/10.1038\/s41419-021-04034-7","journal-title":"Cell Death Dis"},{"issue":"4","key":"4075_CR138","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1007\/s004120000075","volume":"109","author":"D Escalier","year":"2000","unstructured":"Escalier D, Garchon HJ (2000) XMR is associated with the asynapsed segments of sex chromosomes in the XY body of mouse primary spermatocytes. Chromosoma 109(4):259\u2013265. https:\/\/doi.org\/10.1007\/s004120000075","journal-title":"Chromosoma"},{"issue":"2","key":"4075_CR139","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1095\/biolreprod.107.061101","volume":"77","author":"LN Reynard","year":"2007","unstructured":"Reynard LN, Turner JM, Cocquet J, Mahadevaiah SK, Tour\u00e9 A, H\u00f6\u00f6g C, Burgoyne PS (2007) Expression analysis of the mouse multi-copy X-linked gene Xlr-related, meiosis-regulated (Xmr), reveals that Xmr encodes a spermatid-expressed cytoplasmic protein. SLX\/XMR Biol Reprod 77(2):329\u2013335. https:\/\/doi.org\/10.1095\/biolreprod.107.061101","journal-title":"SLX\/XMR Biol Reprod"},{"issue":"2","key":"4075_CR140","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1093\/biolre\/ioy181","volume":"100","author":"S Maezawa","year":"2019","unstructured":"Maezawa S, Alavattam KG, Tatara M, Nagai R, Barski A, Namekawa SH (2019) A rapidly evolved domain, the SCML2 DNA-binding repeats, contributes to chromatin binding of mouse SCML2\u2020. Biol Reprod 100(2):409\u2013419. https:\/\/doi.org\/10.1093\/biolre\/ioy181","journal-title":"Biol Reprod"},{"key":"4075_CR141","doi-asserted-by":"publisher","first-page":"e101379","DOI":"10.15252\/embj.2018101379","volume":"38","author":"S Kilic","year":"2019","unstructured":"Kilic S, Lezaja A, Gatti M, Bianco E, Michelena J, Imhof R, Altmeyer M (2019) Phase separation of 53BP1 determines liquid-like behavior of DNA repair compartments. EMBO J. 38:e101379. https:\/\/doi.org\/10.15252\/embj.2018101379","journal-title":"EMBO J."},{"issue":"1","key":"4075_CR142","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1159\/000015418","volume":"86","author":"D Motzkus","year":"1999","unstructured":"Motzkus D, Singh PB, Hoyer-Fender S (1999) M31, a murine homolog of Drosophila HP1, is concentrated in the XY body during spermatogenesis. Cytogenet Cell Genet 86(1):83\u201388. https:\/\/doi.org\/10.1159\/000015418","journal-title":"Cytogenet Cell Genet"},{"issue":"1","key":"4075_CR143","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1023\/a:1022014217196","volume":"11","author":"C Metzler-Guillemain","year":"2003","unstructured":"Metzler-Guillemain C, Luciani J, Depetris D, Guichaoua MR, Mattei MG (2003) HP1beta and HP1gamma, but not HP1alpha, decorate the entire XY body during human male meiosis. Chromosome Res 11(1):73\u201381. https:\/\/doi.org\/10.1023\/a:1022014217196","journal-title":"Chromosome Res"},{"issue":"2","key":"4075_CR144","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.tibs.2017.11.005","volume":"43","author":"JB Woodruff","year":"2018","unstructured":"Woodruff JB, Hyman AA, Boke E (2018) Organization and function of non-dynamic biomolecular condensates. Trends Biochem Sci 43(2):81\u201394. https:\/\/doi.org\/10.1016\/j.tibs.2017.11.005","journal-title":"Trends Biochem Sci"},{"issue":"23\u201324","key":"4075_CR145","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1101\/gad.331520.119","volume":"33","author":"DT McSwiggen","year":"2019","unstructured":"McSwiggen DT, Mir M, Darzacq X, Tjian R (2019) Evaluating phase separation in live cells: diagnosis, caveats, and functional consequences. Genes Dev 33(23\u201324):1619\u20131634. https:\/\/doi.org\/10.1101\/gad.331520.119","journal-title":"Genes Dev"},{"issue":"3","key":"4075_CR146","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.cell.2018.12.035","volume":"176","author":"S Alberti","year":"2019","unstructured":"Alberti S, Gladfelter A, Mittag T (2019) Considerations and challenges in studying liquid-liquid phase separation and biomolecular condensates. Cell 176(3):419\u2013434. https:\/\/doi.org\/10.1016\/j.cell.2018.12.035","journal-title":"Cell"},{"issue":"12","key":"4075_CR147","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1038\/s41587-019-0341-6","volume":"37","author":"D Bracha","year":"2019","unstructured":"Bracha D, Walls MT, Brangwynne CP (2019) Probing and engineering liquid-phase organelles. Nat Biotechnol 37(12):1435\u20131445. https:\/\/doi.org\/10.1038\/s41587-019-0341-6","journal-title":"Nat Biotechnol"},{"key":"4075_CR148","doi-asserted-by":"publisher","first-page":"47098","DOI":"10.7554\/eLife.47098","volume":"8","author":"DT McSwiggen","year":"2019","unstructured":"McSwiggen DT, Hansen AS, Teves SS, Marie-Nelly H, Hao Y, Heckert AB, Umemoto KK, Dugast-Darzacq C, Tjian R, Darzacq X (2019) Evidence for DNA-mediated nuclear compartmentalization distinct from phase separation. Elife 8:47098. https:\/\/doi.org\/10.7554\/eLife.47098","journal-title":"Elife"},{"issue":"6400","key":"4075_CR149","doi-asserted-by":"publisher","first-page":"aar2555","DOI":"10.1126\/science.aar2555","volume":"361","author":"S Chong","year":"2018","unstructured":"Chong S, Dugast-Darzacq C, Liu Z, Dong P, Dailey GM, Cattoglio C, Heckert A, Banala S, Lavis L, Darzacq X, Tjian R (2018) Imaging dynamic and selective low-complexity domain interactions that control gene transcription. Science 361(6400):aar2555. https:\/\/doi.org\/10.1126\/science.aar2555","journal-title":"Science"},{"issue":"1","key":"4075_CR150","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/mrd.20334","volume":"72","author":"LL Tres","year":"2005","unstructured":"Tres LL (2005) XY chromosomal bivalent: nucleolar attraction. Mol Reprod Dev 72(1):1\u20136. https:\/\/doi.org\/10.1002\/mrd.20334","journal-title":"Mol Reprod Dev"},{"issue":"6451","key":"4075_CR151","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1126\/science.aaw9157","volume":"365","author":"F Frottin","year":"2019","unstructured":"Frottin F, Schueder F, Tiwary S, Gupta R, K\u00f6rner R, Schlichthaerle T, Cox J, Jungmann R, Hartl FU, Hipp MS (2019) The nucleolus functions as a phase-separated protein quality control compartment. Science 365(6451):342\u2013347. https:\/\/doi.org\/10.1126\/science.aaw9157","journal-title":"Science"},{"issue":"7839","key":"4075_CR152","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1038\/s41586-020-2899-z","volume":"588","author":"ZY Wang","year":"2020","unstructured":"Wang ZY, Leushkin E, Liechti A, Ovchinnikova S, M\u00f6\u00dfinger K, Br\u00fcning T, Rummel C, Gr\u00fctzner F, Cardoso-Moreira M, Janich P, Gatfield D, Diagouraga B, de Massy B, Gill ME, Peters A, Anders S, Kaessmann H (2020) Transcriptome and translatome co-evolution in mammals. Nature 588(7839):642\u2013647. https:\/\/doi.org\/10.1038\/s41586-020-2899-z","journal-title":"Nature"},{"issue":"1","key":"4075_CR153","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1093\/biolre\/iox150","volume":"98","author":"J Hu","year":"2018","unstructured":"Hu J, Sun F, Handel MA (2018) Nuclear localization of EIF4G3 suggests a role for the XY body in translational regulation during spermatogenesis in mice. Biol Reprod 98(1):102\u2013114. https:\/\/doi.org\/10.1093\/biolre\/iox150","journal-title":"Biol Reprod"},{"issue":"6968","key":"4075_CR154","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1038\/nature02222","volume":"426","author":"KD Huynh","year":"2003","unstructured":"Huynh KD, Lee JT (2003) Inheritance of a pre-inactivated paternal X chromosome in early mouse embryos. Nature 426(6968):857\u2013862. https:\/\/doi.org\/10.1038\/nature02222","journal-title":"Nature"},{"issue":"5","key":"4075_CR155","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/s0168-9525(03)00058-1","volume":"19","author":"CI Wu","year":"2003","unstructured":"Wu CI, Xu EY (2003) Sexual antagonism and X inactivation\u2013the SAXI hypothesis. Trends Genet 19(5):243\u2013247. https:\/\/doi.org\/10.1016\/s0168-9525(03)00058-1","journal-title":"Trends Genet"},{"issue":"4","key":"4075_CR156","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0060080","volume":"6","author":"L Potrzebowski","year":"2008","unstructured":"Potrzebowski L, Vinckenbosch N, Marques AC, Chalmel F, J\u00e9gou B, Kaessmann H (2008) Chromosomal gene movements reflect the recent origin and biology of therian sex chromosomes. PLoS Biol 6(4):e80. https:\/\/doi.org\/10.1371\/journal.pbio.0060080","journal-title":"PLoS Biol"},{"issue":"10","key":"4075_CR157","doi-asserted-by":"publisher","first-page":"e1000494","DOI":"10.1371\/journal.pbio.1000494","volume":"8","author":"YE Zhang","year":"2010","unstructured":"Zhang YE, Vibranovski MD, Landback P, Marais GA, Long M (2010) Chromosomal redistribution of male-biased genes in mammalian evolution with two bursts of gene gain on the X chromosome. PLoS Biol 8(10):e1000494. https:\/\/doi.org\/10.1371\/journal.pbio.1000494","journal-title":"PLoS Biol"},{"issue":"6","key":"4075_CR158","doi-asserted-by":"publisher","first-page":"R265","DOI":"10.1530\/rep-14-0613","volume":"149","author":"YC Hu","year":"2015","unstructured":"Hu YC, Namekawa SH (2015) Functional significance of the sex chromosomes during spermatogenesis. Reproduction 149(6):R265-277. https:\/\/doi.org\/10.1530\/rep-14-0613","journal-title":"Reproduction"},{"issue":"6","key":"4075_CR159","doi-asserted-by":"publisher","first-page":"E468","DOI":"10.1073\/pnas.1219126110","volume":"110","author":"T Bhattacharyya","year":"2013","unstructured":"Bhattacharyya T, Gregorova S, Mihola O, Anger M, Sebestova J, Denny P, Simecek P, Forejt J (2013) Mechanistic basis of infertility of mouse intersubspecific hybrids. Proc Natl Acad Sci U S A 110(6):E468-477. https:\/\/doi.org\/10.1073\/pnas.1219126110","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"4075_CR160","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1534\/genetics.112.148635","volume":"193","author":"P Campbell","year":"2013","unstructured":"Campbell P, Good JM, Nachman MW (2013) Meiotic sex chromosome inactivation is disrupted in sterile hybrid male house mice. Genetics 193(3):819\u2013828. https:\/\/doi.org\/10.1534\/genetics.112.148635","journal-title":"Genetics"},{"issue":"1","key":"4075_CR161","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1002\/pro.3334","volume":"27","author":"Z Doszt\u00e1nyi","year":"2018","unstructured":"Doszt\u00e1nyi Z (2018) Prediction of protein disorder based on IUPred. Protein Sci 27(1):331\u2013340. https:\/\/doi.org\/10.1002\/pro.3334","journal-title":"Protein Sci"}],"container-title":["Cellular and Molecular Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-021-04075-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00018-021-04075-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-021-04075-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T07:20:50Z","timestamp":1645687250000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00018-021-04075-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,31]]},"references-count":161,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["4075"],"URL":"https:\/\/doi.org\/10.1007\/s00018-021-04075-3","relation":{},"ISSN":["1420-682X","1420-9071"],"issn-type":[{"value":"1420-682X","type":"print"},{"value":"1420-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,31]]},"assertion":[{"value":"1 June 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 December 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"18"}}