{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:12:49Z","timestamp":1790867569919,"version":"4.1.0"},"reference-count":139,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T00:00:00Z","timestamp":1640822400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T00:00:00Z","timestamp":1640822400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Agence nationale de la recherche, \u2018Investissements d\u2019avenir\u2019 program","award":["ANR-10-IAIHU-06"],"award-info":[{"award-number":["ANR-10-IAIHU-06"]}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"crossref","award":["FDT202012010523"],"award-info":[{"award-number":["FDT202012010523"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Fondation Assitance Publique-H\u00f4pitaux de Paris","award":["EPIRES"],"award-info":[{"award-number":["EPIRES"]}]},{"name":"Fondation Assitance Publique-H\u00f4pitaux de Paris","award":["Marie Laure PLV Merchandising"],"award-info":[{"award-number":["Marie Laure PLV Merchandising"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell. Mol. Life Sci."],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1007\/s00018-021-04088-y","type":"journal-article","created":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T10:02:11Z","timestamp":1640858531000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["The LGI1 protein: molecular structure, physiological functions and disruption-related seizures"],"prefix":"10.1007","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8714-5784","authenticated-orcid":false,"given":"Paul","family":"Baudin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1407-5575","authenticated-orcid":false,"given":"Louis","family":"Cousyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0077-8114","authenticated-orcid":false,"given":"Vincent","family":"Navarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,12,30]]},"reference":[{"key":"4088_CR1","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1093\/hmg\/ddi169","volume":"14","author":"KR Senechal","year":"2005","unstructured":"Senechal KR, Thaller C, Noebels JL (2005) ADPEAF mutations reduce levels of secreted LGI1, a putative tumor suppressor protein linked to epilepsy. Hum Mol Genet 14:1613\u20131620. https:\/\/doi.org\/10.1093\/hmg\/ddi169","journal-title":"Hum Mol Genet"},{"key":"4088_CR2","doi-asserted-by":"publisher","first-page":"1792","DOI":"10.1126\/science.1129947","volume":"313","author":"Y Fukata","year":"2006","unstructured":"Fukata Y, Adesnik H, Iwanaga T et al (2006) Epilepsy-related ligand\/receptor complex LGI1 and ADAM22 regulate synaptic transmission. Science 313:1792\u20131795. https:\/\/doi.org\/10.1126\/science.1129947","journal-title":"Science"},{"key":"4088_CR3","doi-asserted-by":"publisher","first-page":"3436","DOI":"10.1093\/hmg\/ddl421","volume":"15","author":"MS Sirerol-Piquer","year":"2006","unstructured":"Sirerol-Piquer MS, Ayerdi-Izquierdo A, Morante-Redolat JM et al (2006) The epilepsy gene LGI1 encodes a secreted glycoprotein that binds to the cell surface. Hum Mol Genet 15:3436\u20133445. https:\/\/doi.org\/10.1093\/hmg\/ddl421","journal-title":"Hum Mol Genet"},{"key":"4088_CR4","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1152\/physrev.00010.2016","volume":"97","author":"J Dalmau","year":"2017","unstructured":"Dalmau J, Geis C, Graus F (2017) Autoantibodies to synaptic receptors and neuronal cell surface proteins in autoimmune diseases of the central nervous system. Physiol Rev 97:839\u2013887. https:\/\/doi.org\/10.1152\/physrev.00010.2016","journal-title":"Physiol Rev"},{"key":"4088_CR5","doi-asserted-by":"publisher","first-page":"287","DOI":"10.4997\/JRCPE.2019.407","volume":"49","author":"JA Goodfellow","year":"2019","unstructured":"Goodfellow JA, Mackay GA (2019) Autoimmune encephalitis. J R Coll Physicians Edinb 49:287\u2013294. https:\/\/doi.org\/10.4997\/JRCPE.2019.407","journal-title":"J R Coll Physicians Edinb"},{"key":"4088_CR6","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1007\/s13311-019-00750-3","volume":"16","author":"KS Husari","year":"2019","unstructured":"Husari KS, Dubey D (2019) Autoimmune epilepsy. Neurotherapeutics 16:685\u2013702. https:\/\/doi.org\/10.1007\/s13311-019-00750-3","journal-title":"Neurotherapeutics"},{"key":"4088_CR7","doi-asserted-by":"publisher","first-page":"2734","DOI":"10.1093\/brain\/awq213","volume":"133","author":"SR Irani","year":"2010","unstructured":"Irani SR, Alexander S, Waters P et al (2010) Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan\u2019s syndrome and acquired neuromyotonia. Brain 133:2734\u20132748. https:\/\/doi.org\/10.1093\/brain\/awq213","journal-title":"Brain"},{"key":"4088_CR8","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1002\/ana.22307","volume":"69","author":"SR Irani","year":"2011","unstructured":"Irani SR, Michell AW, Lang B et al (2011) Faciobrachial dystonic seizures precede Lgi1 antibody limbic encephalitis. Ann Neurol 69:892\u2013900. https:\/\/doi.org\/10.1002\/ana.22307","journal-title":"Ann Neurol"},{"key":"4088_CR9","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1016\/S1474-4422(10)70137-X","volume":"9","author":"M Lai","year":"2010","unstructured":"Lai M, Huijbers MG, Lancaster E et al (2010) Investigation of LGI1 as the antigen in limbic encephalitis previously attributed to potassium channels: a case series. Lancet Neurol 9:776\u2013785. https:\/\/doi.org\/10.1016\/S1474-4422(10)70137-X","journal-title":"Lancet Neurol"},{"key":"4088_CR10","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1093\/brain\/aww012","volume":"139","author":"V Navarro","year":"2016","unstructured":"Navarro V, Kas A, Apartis E et al (2016) Motor cortex and hippocampus are the two main cortical targets in LGI1-antibody encephalitis. Brain 139:1079\u20131093. https:\/\/doi.org\/10.1093\/brain\/aww012","journal-title":"Brain"},{"key":"4088_CR11","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1111\/jvim.12610","volume":"29","author":"A Pakozdy","year":"2015","unstructured":"Pakozdy A, Patzl M, Zimmermann L et al (2015) LGI proteins and epilepsy in human and animals. J Vet Intern Med 29:997\u20131005. https:\/\/doi.org\/10.1111\/jvim.12610","journal-title":"J Vet Intern Med"},{"key":"4088_CR12","doi-asserted-by":"publisher","first-page":"2873","DOI":"10.1038\/sj.onc.1202481","volume":"17","author":"OB Chernova","year":"1998","unstructured":"Chernova OB, Somerville RP, Cowell JK (1998) A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors. Oncogene 17:2873\u20132881. https:\/\/doi.org\/10.1038\/sj.onc.1202481","journal-title":"Oncogene"},{"key":"4088_CR13","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/s004010100463","volume":"103","author":"D Krex","year":"2002","unstructured":"Krex D, Hauses M, Appelt H et al (2002) Physical and functional characterization of the human LGI1 gene and its possible role in glioma development. Acta Neuropathol 103:255\u2013266. https:\/\/doi.org\/10.1007\/s004010100463","journal-title":"Acta Neuropathol"},{"key":"4088_CR14","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1007\/s00428-003-0874-3","volume":"443","author":"R Besleaga","year":"2003","unstructured":"Besleaga R, Montesinos-Rongen M, Perez-Tur J et al (2003) Expression of the LGI1 gene product in astrocytic gliomas: downregulation with malignant progression. Virchows Arch 443:561\u2013564. https:\/\/doi.org\/10.1007\/s00428-003-0874-3","journal-title":"Virchows Arch"},{"key":"4088_CR15","doi-asserted-by":"publisher","first-page":"3985","DOI":"10.1038\/sj.onc.1206584","volume":"22","author":"P Kunapuli","year":"2003","unstructured":"Kunapuli P, Chitta KS, Cowell JK (2003) Suppression of the cell proliferation and invasion phenotypes in glioma cells by the LGI1 gene. Oncogene 22:3985\u20133991. https:\/\/doi.org\/10.1038\/sj.onc.1206584","journal-title":"Oncogene"},{"key":"4088_CR16","doi-asserted-by":"publisher","first-page":"23151","DOI":"10.1074\/jbc.M314192200","volume":"279","author":"P Kunapuli","year":"2004","unstructured":"Kunapuli P, Kasyapa CS, Hawthorn L, Cowell JK (2004) LGI1, a putative tumor metastasis suppressor gene, controls in vitro invasiveness and expression of matrix metalloproteinases in glioma cells through the ERK1\/2 pathway. J Biol Chem 279:23151\u201323157. https:\/\/doi.org\/10.1074\/jbc.M314192200","journal-title":"J Biol Chem"},{"key":"4088_CR17","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1002\/jcp.20627","volume":"207","author":"G Nadia","year":"2006","unstructured":"Nadia G, Masola V, Quartesan S et al (2006) Increased expression ofLGI1 gene triggers growth inhibition and apoptosis of neuroblastoma cells. J Cell Physiol 207:711\u2013721. https:\/\/doi.org\/10.1002\/jcp.20627","journal-title":"J Cell Physiol"},{"key":"4088_CR18","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1215\/15228517-2005-006","volume":"8","author":"T Piepoli","year":"2006","unstructured":"Piepoli T, Jakupoglu C, Gu W et al (2006) Expression studies in gliomas and glial cells do not support a tumor suppressor role for LGI11. Neuro Oncol 8:96\u2013108. https:\/\/doi.org\/10.1215\/15228517-2005-006","journal-title":"Neuro Oncol"},{"key":"4088_CR19","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/s10048-005-0216-5","volume":"6","author":"W Gu","year":"2005","unstructured":"Gu W, Brodtkorb E, Piepoli T et al (2005) LGI1: a gene involved in epileptogenesis and glioma progression? Neurogenetics 6:59\u201366. https:\/\/doi.org\/10.1007\/s10048-005-0216-5","journal-title":"Neurogenetics"},{"key":"4088_CR20","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1002\/ana.24979","volume":"82","author":"A Gadoth","year":"2017","unstructured":"Gadoth A, Pittock SJ, Dubey D et al (2017) Expanded phenotypes and outcomes among 256 LGI1\/CASPR2-IgG-positive patients. Ann Neurol 82:79\u201392. https:\/\/doi.org\/10.1002\/ana.24979","journal-title":"Ann Neurol"},{"key":"4088_CR21","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1007\/s0033500101280","volume":"11","author":"RPT Somerville","year":"2000","unstructured":"Somerville RPT, Chernova O, Liu S et al (2000) Identification of the promoter, genomic structure, and mouse ortholog of LGI1. Mamm Genome 11:622\u2013627. https:\/\/doi.org\/10.1007\/s0033500101280","journal-title":"Mamm Genome"},{"key":"4088_CR22","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.eplepsyres.2007.06.014","volume":"76","author":"E Chabrol","year":"2007","unstructured":"Chabrol E, Gourfinkel-An I, Scheffer IE et al (2007) Absence of mutations in the LGI1 receptor ADAM22 gene in autosomal dominant lateral temporal epilepsy. Epilepsy Res 76:41\u201348. https:\/\/doi.org\/10.1016\/j.eplepsyres.2007.06.014","journal-title":"Epilepsy Res"},{"key":"4088_CR23","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.eplepsyres.2009.02.007","volume":"85","author":"J de Bellescize","year":"2009","unstructured":"de Bellescize J, Boutry N, Chabrol E et al (2009) A novel three base-pair LGI1 deletion leading to loss of function in a family with autosomal dominant lateral temporal epilepsy and migraine-like episodes. Epilepsy Res 85:118\u2013122. https:\/\/doi.org\/10.1016\/j.eplepsyres.2009.02.007","journal-title":"Epilepsy Res"},{"key":"4088_CR24","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1007\/s00335-007-9024-6","volume":"18","author":"K Head","year":"2007","unstructured":"Head K, Gong S, Joseph S et al (2007) Defining the expression pattern of the LGI1 gene in BAC transgenic mice. Mamm Genome 18:328\u2013337. https:\/\/doi.org\/10.1007\/s00335-007-9024-6","journal-title":"Mamm Genome"},{"key":"4088_CR25","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/S0014-5793(02)02713-8","volume":"519","author":"W Gu","year":"2002","unstructured":"Gu W, Wevers A, Schr\u00f6der H et al (2002) The LGI1 gene involved in lateral temporal lobe epilepsy belongs to a new subfamily of leucine-rich repeat proteins. FEBS Lett 519:71\u201376. https:\/\/doi.org\/10.1016\/S0014-5793(02)02713-8","journal-title":"FEBS Lett"},{"key":"4088_CR26","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1038\/s41467-018-03947-w","volume":"9","author":"A Yamagata","year":"2018","unstructured":"Yamagata A, Miyazaki Y, Yokoi N et al (2018) Structural basis of epilepsy-related ligand\u2013receptor complex LGI1\u2013ADAM22. Nat Commun 9:1546. https:\/\/doi.org\/10.1038\/s41467-018-03947-w","journal-title":"Nat Commun"},{"key":"4088_CR27","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.1093\/hmg\/11.15.1757","volume":"11","author":"H Scheel","year":"2002","unstructured":"Scheel H (2002) A common protein interaction domain links two recently identified epilepsy genes. Hum Mol Genet 11:1757\u20131762. https:\/\/doi.org\/10.1093\/hmg\/11.15.1757","journal-title":"Hum Mol Genet"},{"key":"4088_CR28","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/S0968-0004(02)02163-1","volume":"27","author":"E Staub","year":"2002","unstructured":"Staub E, P\u00e9rez-Tur J, Siebert R et al (2002) The novel EPTP repeat defines a superfamily of proteins implicated in epileptic disorders. Trends Biochem Sci 27:441\u2013444. https:\/\/doi.org\/10.1016\/S0968-0004(02)02163-1","journal-title":"Trends Biochem Sci"},{"key":"4088_CR29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018142","volume":"6","author":"E Leonardi","year":"2011","unstructured":"Leonardi E, Andreazza S, Vanin S et al (2011) A computational model of the LGI1 protein suggests a common binding site for ADAM proteins. PLoS ONE 6:e18142. https:\/\/doi.org\/10.1371\/journal.pone.0018142","journal-title":"PLoS ONE"},{"key":"4088_CR30","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1016\/s0959-440x(01)00266-4","volume":"11","author":"B Kobe","year":"2001","unstructured":"Kobe B, Kajava AV (2001) The leucine-rich repeat as a protein recognition motif. Curr Opin Struct Biol 11:725\u2013732. https:\/\/doi.org\/10.1016\/s0959-440x(01)00266-4","journal-title":"Curr Opin Struct Biol"},{"key":"4088_CR31","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/1471-2202-12-43","volume":"12","author":"J Silva","year":"2011","unstructured":"Silva J, Wang G, Cowell JK (2011) The temporal and spatial expression pattern of the LGI1 epilepsy predisposition gene during mouse embryonic cranial development. BMC Neurosci 12:43. https:\/\/doi.org\/10.1186\/1471-2202-12-43","journal-title":"BMC Neurosci"},{"key":"4088_CR32","doi-asserted-by":"publisher","first-page":"2984","DOI":"10.1093\/brain\/awu259","volume":"137","author":"M Boillot","year":"2014","unstructured":"Boillot M, Huneau C, Marsan E et al (2014) Glutamatergic neuron-targeted loss of LGI1 epilepsy gene results in seizures. Brain 137:2984\u20132996. https:\/\/doi.org\/10.1093\/brain\/awu259","journal-title":"Brain"},{"key":"4088_CR33","doi-asserted-by":"publisher","first-page":"18161","DOI":"10.1523\/JNEUROSCI.3506-13.2013","volume":"33","author":"T Ohkawa","year":"2013","unstructured":"Ohkawa T, Fukata Y, Yamasaki M et al (2013) Autoantibodies to epilepsy-related LGI1 in limbic encephalitis neutralize LGI1-ADAM22 interaction and reduce synaptic AMPA receptors. J Neurosci 33:18161\u201318174. https:\/\/doi.org\/10.1523\/JNEUROSCI.3506-13.2013","journal-title":"J Neurosci"},{"key":"4088_CR34","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1002\/ana.25666","volume":"87","author":"H Kornau","year":"2020","unstructured":"Kornau H, Kreye J, Stumpf A et al (2020) Human cerebrospinal fluid monoclonal LGI1 autoantibodies increase neuronal excitability. Ann Neurol 87:405\u2013418. https:\/\/doi.org\/10.1002\/ana.25666","journal-title":"Ann Neurol"},{"key":"4088_CR35","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1093\/hmg\/11.9.1119","volume":"11","author":"JM Morante-Redolat","year":"2002","unstructured":"Morante-Redolat JM (2002) Mutations in the LGI1\/Epitempin gene on 10q24 cause autosomal dominant lateral temporal epilepsy. Hum Mol Genet 11:1119\u20131128. https:\/\/doi.org\/10.1093\/hmg\/11.9.1119","journal-title":"Hum Mol Genet"},{"key":"4088_CR36","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1111\/j.1471-4159.2006.03939.x","volume":"98","author":"S Furlan","year":"2006","unstructured":"Furlan S, Roncaroli F, Forner F et al (2006) The LGI1\/epitempin gene encodes two protein isoforms differentially expressed in human brain. J Neurochem 98:985\u2013991. https:\/\/doi.org\/10.1111\/j.1471-4159.2006.03939.x","journal-title":"J Neurochem"},{"key":"4088_CR37","doi-asserted-by":"publisher","first-page":"2749","DOI":"10.1093\/brain\/awq171","volume":"133","author":"E Chabrol","year":"2010","unstructured":"Chabrol E, Navarro V, Provenzano G et al (2010) Electroclinical characterization of epileptic seizures in leucine-rich, glioma-inactivated 1-deficient mice. Brain 133:2749\u20132762. https:\/\/doi.org\/10.1093\/brain\/awq171","journal-title":"Brain"},{"key":"4088_CR38","doi-asserted-by":"publisher","first-page":"231","DOI":"10.3389\/fnmol.2018.00231","volume":"11","author":"Y-J Xie","year":"2018","unstructured":"Xie Y-J, Zhou L, Wang Y et al (2018) Leucine-rich glioma inactivated 1 promotes oligodendrocyte differentiation and myelination via TSC-mTOR signaling. Front Mol Neurosci 11:231. https:\/\/doi.org\/10.3389\/fnmol.2018.00231","journal-title":"Front Mol Neurosci"},{"key":"4088_CR39","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/ng832","volume":"30","author":"S Kalachikov","year":"2002","unstructured":"Kalachikov S, Evgrafov O, Ross B et al (2002) Mutations in LGI1 cause autosomal-dominant partial epilepsy with auditory features. Nat Genet 30:335\u2013341. https:\/\/doi.org\/10.1038\/ng832","journal-title":"Nat Genet"},{"key":"4088_CR40","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.brainres.2009.10.013","volume":"1307","author":"V Herranz-P\u00e9rez","year":"2010","unstructured":"Herranz-P\u00e9rez V, Olucha-Bordonau FE, Morante-Redolat JM, P\u00e9rez-Tur J (2010) Regional distribution of the leucine-rich glioma inactivated (LGI) gene family transcripts in the adult mouse brain. Brain Res 1307:177\u2013194. https:\/\/doi.org\/10.1016\/j.brainres.2009.10.013","journal-title":"Brain Res"},{"key":"4088_CR41","doi-asserted-by":"publisher","first-page":"42","DOI":"10.3389\/fnmol.2018.00042","volume":"11","author":"G Smedfors","year":"2018","unstructured":"Smedfors G, Olson L, Karlsson TE (2018) A Nogo-like signaling perspective from birth to adulthood and in old age: brain expression patterns of ligands, receptors and modulators. Front Mol Neurosci 11:42. https:\/\/doi.org\/10.3389\/fnmol.2018.00042","journal-title":"Front Mol Neurosci"},{"key":"4088_CR42","doi-asserted-by":"publisher","first-page":"E4129","DOI":"10.1073\/pnas.1511910112","volume":"112","author":"KL Lovero","year":"2015","unstructured":"Lovero KL, Fukata Y, Granger AJ et al (2015) The LGI1\u2013ADAM22 protein complex directs synapse maturation through regulation of PSD-95 function. Proc Natl Acad Sci USA 112:E4129\u2013E4137. https:\/\/doi.org\/10.1073\/pnas.1511910112","journal-title":"Proc Natl Acad Sci USA"},{"key":"4088_CR43","doi-asserted-by":"publisher","first-page":"21769","DOI":"10.1038\/srep21769","volume":"6","author":"M Boillot","year":"2016","unstructured":"Boillot M, Lee C-Y, Allene C et al (2016) LGI1 acts presynaptically to regulate excitatory synaptic transmission during early postnatal development. Sci Rep 6:21769. https:\/\/doi.org\/10.1038\/srep21769","journal-title":"Sci Rep"},{"key":"4088_CR44","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2022580118","volume":"118","author":"Y Fukata","year":"2021","unstructured":"Fukata Y, Chen X, Chiken S et al (2021) LGI1\u2013ADAM22\u2013MAGUK configures transsynaptic nanoalignment for synaptic transmission and epilepsy prevention. Proc Natl Acad Sci USA 118:e2022580118. https:\/\/doi.org\/10.1073\/pnas.2022580118","journal-title":"Proc Natl Acad Sci USA"},{"key":"4088_CR45","doi-asserted-by":"publisher","first-page":"7719","DOI":"10.1073\/pnas.1618656114","volume":"114","author":"M Seagar","year":"2017","unstructured":"Seagar M, Russier M, Caillard O et al (2017) LGI1 tunes intrinsic excitability by regulating the density of axonal Kv1 channels. Proc Natl Acad Sci USA 114:7719\u20137724. https:\/\/doi.org\/10.1073\/pnas.1618656114","journal-title":"Proc Natl Acad Sci USA"},{"key":"4088_CR46","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.219774","author":"B Hivert","year":"2019","unstructured":"Hivert B, Marien L, Agbam KN, Faivre-Sarrailh C (2019) ADAM22 and ADAM23 modulate the targeting of the Kv1 channel-associated protein LGI1 to the axon initial segment. J Cell Sci. https:\/\/doi.org\/10.1242\/jcs.219774","journal-title":"J Cell Sci"},{"key":"4088_CR47","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1007\/s12031-008-9096-0","volume":"35","author":"PAO Ribeiro","year":"2008","unstructured":"Ribeiro PAO, Sbragia L, Gilioli R et al (2008) Expression profile of Lgi1 gene in mouse brain during development. J Mol Neurosci 35:323\u2013329. https:\/\/doi.org\/10.1007\/s12031-008-9096-0","journal-title":"J Mol Neurosci"},{"key":"4088_CR48","doi-asserted-by":"publisher","first-page":"6607","DOI":"10.1523\/JNEUROSCI.5147-09.2010","volume":"30","author":"R Thomas","year":"2010","unstructured":"Thomas R, Favell K, Morante-Redolat J et al (2010) LGI1 Is a nogo receptor 1 ligand that antagonizes myelin-based growth inhibition. J Neurosci 30:6607\u20136612. https:\/\/doi.org\/10.1523\/JNEUROSCI.5147-09.2010","journal-title":"J Neurosci"},{"key":"4088_CR49","doi-asserted-by":"publisher","first-page":"2284","DOI":"10.1111\/j.1460-9568.2012.08129.x","volume":"36","author":"S Kusuzawa","year":"2012","unstructured":"Kusuzawa S, Honda T, Fukata Y et al (2012) Leucine-rich glioma inactivated 1 (Lgi1), an epilepsy-related secreted protein, has a nuclear localization signal and localizes to both the cytoplasm and the nucleus of the caudal ganglionic eminence neurons: nuclear translocation of Lgi1. Eur J Neurosci 36:2284\u20132292. https:\/\/doi.org\/10.1111\/j.1460-9568.2012.08129.x","journal-title":"Eur J Neurosci"},{"key":"4088_CR50","doi-asserted-by":"publisher","first-page":"3799","DOI":"10.1073\/pnas.0914537107","volume":"107","author":"Y Fukata","year":"2010","unstructured":"Fukata Y, Lovero KL, Iwanaga T et al (2010) Disruption of LGI1\u2013linked synaptic complex causes abnormal synaptic transmission and epilepsy. Proc Natl Acad Sci USA 107:3799\u20133804. https:\/\/doi.org\/10.1073\/pnas.0914537107","journal-title":"Proc Natl Acad Sci USA"},{"key":"4088_CR51","doi-asserted-by":"publisher","first-page":"3296","DOI":"10.1242\/jcs.03065","volume":"119","author":"NJ G\u00f6dde","year":"2006","unstructured":"G\u00f6dde NJ, D\u2019Abaco GM, Paradiso L, Novak U (2006) Efficient ADAM22 surface expression is mediated by phosphorylation-dependent interaction with 14\u20133-3 protein family members. J Cell Sci 119:3296\u20133305. https:\/\/doi.org\/10.1242\/jcs.03065","journal-title":"J Cell Sci"},{"key":"4088_CR52","doi-asserted-by":"publisher","first-page":"1702","DOI":"10.1093\/hmg\/ddq047","volume":"19","author":"YE Yu","year":"2010","unstructured":"Yu YE, Wen L, Silva J et al (2010) Lgi1 null mutant mice exhibit myoclonic seizures and CA1 neuronal hyperexcitability. Hum Mol Genet 19:1702\u20131711. https:\/\/doi.org\/10.1093\/hmg\/ddq047","journal-title":"Hum Mol Genet"},{"key":"4088_CR53","doi-asserted-by":"publisher","first-page":"11433","DOI":"10.1523\/JNEUROSCI.1346-15.2015","volume":"35","author":"MJ Kole","year":"2015","unstructured":"Kole MJ, Qian J, Waase MP et al (2015) Selective loss of presynaptic potassium channel clusters at the cerebellar basket cell terminal pinceau in adam11 mutants reveals their role in ephaptic control of Purkinje cell firing. J Neurosci 35:11433\u201311444. https:\/\/doi.org\/10.1523\/JNEUROSCI.1346-15.2015","journal-title":"J Neurosci"},{"key":"4088_CR54","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/1471-2202-6-33","volume":"6","author":"K Sagane","year":"2005","unstructured":"Sagane K, Hayakawa K, Kai J et al (2005) Ataxia and peripheral nerve hypomyelination in ADAM22-deficient mice. BMC Neurosci 6:33. https:\/\/doi.org\/10.1186\/1471-2202-6-33","journal-title":"BMC Neurosci"},{"key":"4088_CR55","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.mcn.2009.09.008","volume":"42","author":"K Owuor","year":"2009","unstructured":"Owuor K, Harel NY, Englot DJ et al (2009) LGI1-associated epilepsy through altered ADAM23-dependent neuronal morphology. Mol Cell Neurosci 42:448\u2013457. https:\/\/doi.org\/10.1016\/j.mcn.2009.09.008","journal-title":"Mol Cell Neurosci"},{"key":"4088_CR56","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1016\/S0896-6273(00)81018-1","volume":"20","author":"SL Smart","year":"1998","unstructured":"Smart SL, Lopantsev V, Zhang CL et al (1998) Deletion of the KV1.1 potassium channel causes epilepsy in mice. Neuron 20:809\u2013819. https:\/\/doi.org\/10.1016\/S0896-6273(00)81018-1","journal-title":"Neuron"},{"key":"4088_CR57","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1152\/jn.00640.2006","volume":"98","author":"HM Brew","year":"2007","unstructured":"Brew HM, Gittelman JX, Silverstein RS et al (2007) Seizures and reduced life span in mice lacking the potassium channel subunit Kv1.2, but hypoexcitability and enlarged Kv1 currents in auditory neurons. J Neurophysiol 98:1501\u20131525. https:\/\/doi.org\/10.1152\/jn.00640.2006","journal-title":"J Neurophysiol"},{"key":"4088_CR58","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.mam.2008.08.001","volume":"29","author":"D Edwards","year":"2008","unstructured":"Edwards D, Handsley M, Pennington C (2008) The ADAM metalloproteinases. Mol Aspects Med 29:258\u2013289. https:\/\/doi.org\/10.1016\/j.mam.2008.08.001","journal-title":"Mol Aspects Med"},{"key":"4088_CR59","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/s0378-1119(99)00253-x","volume":"236","author":"K Sagane","year":"1999","unstructured":"Sagane K, Yamazaki K, Mizui Y, Tanaka I (1999) Cloning and chromosomal mapping of mouse ADAM11, ADAM22 and ADAM23. Gene 236:79\u201386. https:\/\/doi.org\/10.1016\/s0378-1119(99)00253-x","journal-title":"Gene"},{"key":"4088_CR60","doi-asserted-by":"publisher","first-page":"29077","DOI":"10.1074\/jbc.M109.014258","volume":"284","author":"H Liu","year":"2009","unstructured":"Liu H, Shim AHR, He X (2009) Structural characterization of the ectodomain of a disintegrin and metalloproteinase-22 (ADAM22), a neural adhesion receptor instead of metalloproteinase. J Biol Chem 284:29077\u201329086. https:\/\/doi.org\/10.1074\/jbc.M109.014258","journal-title":"J Biol Chem"},{"key":"4088_CR61","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1126\/science.290.5495.1364","volume":"290","author":"AE El-Husseini","year":"2000","unstructured":"El-Husseini AE, Schnell E, Chetkovich DM et al (2000) PSD-95 involvement in maturation of excitatory synapses. Science 290:1364\u20131368","journal-title":"Science"},{"key":"4088_CR62","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/nm.3759","volume":"21","author":"N Yokoi","year":"2015","unstructured":"Yokoi N, Fukata Y, Kase D et al (2015) Chemical corrector treatment ameliorates increased seizure susceptibility in a mouse model of familial epilepsy. Nat Med 21:19\u201326. https:\/\/doi.org\/10.1038\/nm.3759","journal-title":"Nat Med"},{"key":"4088_CR63","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1038\/35053072","volume":"409","author":"AE Fournier","year":"2001","unstructured":"Fournier AE, GrandPre T, Strittmatter SM (2001) Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration. Nature 409:341\u2013346. https:\/\/doi.org\/10.1038\/35053072","journal-title":"Nature"},{"key":"4088_CR64","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0185-18.2018","author":"RA Thomas","year":"2018","unstructured":"Thomas RA, Gibon J, Chen CXQ et al (2018) The Nogo receptor ligand LGI1 regulates synapse number and synaptic activity in hippocampal and cortical neurons. eNeuro. https:\/\/doi.org\/10.1523\/ENEURO.0185-18.2018","journal-title":"eNeuro"},{"key":"4088_CR65","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1016\/j.neuron.2006.01.033","volume":"49","author":"U Schulte","year":"2006","unstructured":"Schulte U, Thumfart J-O, Kl\u00f6cker N et al (2006) The epilepsy-linked Lgi1 protein assembles into presynaptic Kv1 channels and inhibits inactivation by Kvbeta1. Neuron 49:697\u2013706. https:\/\/doi.org\/10.1016\/j.neuron.2006.01.033","journal-title":"Neuron"},{"key":"4088_CR66","doi-asserted-by":"publisher","first-page":"1823","DOI":"10.1073\/pnas.0606636104","volume":"104","author":"LP Savtchenko","year":"2007","unstructured":"Savtchenko LP, Rusakov DA (2007) The optimal height of the synaptic cleft. Proc Natl Acad Sci U S A 104:1823\u20131828. https:\/\/doi.org\/10.1073\/pnas.0606636104","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4088_CR67","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1111\/bpa.12225","volume":"25","author":"J Silva","year":"2015","unstructured":"Silva J, Sharma S, Cowell JK (2015) Homozygous deletion of the LGI1 gene in mice leads to developmental abnormalities resulting in cortical dysplasia: loss of LGI1 leads to cortical dysplasia. Brain Pathol 25:587\u2013597. https:\/\/doi.org\/10.1111\/bpa.12225","journal-title":"Brain Pathol"},{"key":"4088_CR68","doi-asserted-by":"publisher","first-page":"e23268","DOI":"10.1002\/dvg.23268","volume":"57","author":"J Silva","year":"2019","unstructured":"Silva J, Qin H, Cowell JK (2019) Selective inactivation of LGI1 in neuronal precursor cells leads to cortical dysplasia in mice. Genesis 57:e23268. https:\/\/doi.org\/10.1002\/dvg.23268","journal-title":"Genesis"},{"key":"4088_CR69","doi-asserted-by":"publisher","first-page":"7827","DOI":"10.1038\/srep07827","volume":"5","author":"Y-J Xie","year":"2015","unstructured":"Xie Y-J, Zhou L, Jiang N et al (2015) Essential roles of leucine-rich glioma inactivated 1 in the development of embryonic and postnatal cerebellum. Sci Rep 5:7827. https:\/\/doi.org\/10.1038\/srep07827","journal-title":"Sci Rep"},{"key":"4088_CR70","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.neuron.2011.11.029","volume":"73","author":"ZP Wills","year":"2012","unstructured":"Wills ZP, Mandel-Brehm C, Mardinly AR et al (2012) The Nogo receptor family restricts synapse number in the developing hippocampus. Neuron 73:466\u2013481. https:\/\/doi.org\/10.1016\/j.neuron.2011.11.029","journal-title":"Neuron"},{"key":"4088_CR71","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1038\/35044547","volume":"1","author":"L Luo","year":"2000","unstructured":"Luo L (2000) Rho GTPases in neuronal morphogenesis. Nat Rev Neurosci 1:173\u2013180. https:\/\/doi.org\/10.1038\/35044547","journal-title":"Nat Rev Neurosci"},{"key":"4088_CR72","doi-asserted-by":"publisher","first-page":"3328","DOI":"10.1002\/jnr.22496","volume":"88","author":"J Silva","year":"2010","unstructured":"Silva J, Sharma S, Hughes B et al (2010) Homozygous inactivation of the LGI1 gene results in hypomyelination in the peripheral and central nervous systems: hypomyelination in LGI1 null mice. J Neurosci Res 88:3328\u20133336. https:\/\/doi.org\/10.1002\/jnr.22496","journal-title":"J Neurosci Res"},{"key":"4088_CR73","doi-asserted-by":"publisher","first-page":"8432","DOI":"10.1523\/JNEUROSCI.1105-14.2014","volume":"34","author":"F Lebrun-Julien","year":"2014","unstructured":"Lebrun-Julien F, Bachmann L, Norrm\u00e9n C et al (2014) Balanced mTORC1 activity in oligodendrocytes is required for accurate CNS myelination. J Neurosci 34:8432\u20138448. https:\/\/doi.org\/10.1523\/JNEUROSCI.1105-14.2014","journal-title":"J Neurosci"},{"key":"4088_CR74","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.pharmthera.2016.01.005","volume":"159","author":"SV Ovsepian","year":"2016","unstructured":"Ovsepian SV, LeBerre M, Steuber V et al (2016) Distinctive role of KV1.1 subunit in the biology and functions of low threshold K+ channels with implications for neurological disease. Pharmacol Ther 159:93\u2013101. https:\/\/doi.org\/10.1016\/j.pharmthera.2016.01.005","journal-title":"Pharmacol Ther"},{"key":"4088_CR75","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.tins.2004.02.012","volume":"27","author":"PD Dodson","year":"2004","unstructured":"Dodson PD, Forsythe ID (2004) Presynaptic K+ channels: electrifying regulators of synaptic terminal excitability. Trends Neurosci 27:210\u2013217. https:\/\/doi.org\/10.1016\/j.tins.2004.02.012","journal-title":"Trends Neurosci"},{"key":"4088_CR76","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.neuron.2014.12.042","volume":"85","author":"JS Trimmer","year":"2015","unstructured":"Trimmer JS (2015) Subcellular localization of K+ channels in mammalian brain neurons: remarkable precision in the midst of extraordinary complexity. Neuron 85:238\u2013256. https:\/\/doi.org\/10.1016\/j.neuron.2014.12.042","journal-title":"Neuron"},{"key":"4088_CR77","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1113\/jphysiol.2005.097006","volume":"571","author":"D Guan","year":"2006","unstructured":"Guan D, Lee JCF, Tkatch T et al (2006) Expression and biophysical properties of Kv1 channels in supragranular neocortical pyramidal neurones. J Physiol 571:371\u2013389. https:\/\/doi.org\/10.1113\/jphysiol.2005.097006","journal-title":"J Physiol"},{"key":"4088_CR78","doi-asserted-by":"publisher","first-page":"1931","DOI":"10.1152\/jn.00933.2006","volume":"97","author":"D Guan","year":"2007","unstructured":"Guan D, Lee JCF, Higgs MH et al (2007) Functional roles of Kv1 channels in neocortical pyramidal neurons. J Neurophysiol 97:1931\u20131940. https:\/\/doi.org\/10.1152\/jn.00933.2006","journal-title":"J Neurophysiol"},{"key":"4088_CR79","doi-asserted-by":"publisher","first-page":"12885","DOI":"10.1523\/JNEUROSCI.0740-10.2010","volume":"30","author":"RH Cudmore","year":"2010","unstructured":"Cudmore RH, Fronzaroli-Molinieres L, Giraud P, Debanne D (2010) Spike-time precision and network synchrony are controlled by the homeostatic regulation of the D-type potassium current. J Neurosci 30:12885\u201312895. https:\/\/doi.org\/10.1523\/JNEUROSCI.0740-10.2010","journal-title":"J Neurosci"},{"key":"4088_CR80","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1038\/nature00978","volume":"419","author":"G Yellen","year":"2002","unstructured":"Yellen G (2002) The voltage-gated potassium channels and their relatives. Nature 419:35\u201342. https:\/\/doi.org\/10.1038\/nature00978","journal-title":"Nature"},{"key":"4088_CR81","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.1113\/jphysiol.2012.249706","volume":"591","author":"SV Ovsepian","year":"2013","unstructured":"Ovsepian SV, Steuber V, Le Berre M et al (2013) A defined heteromeric K V 1 channel stabilizes the intrinsic pacemaking and regulates the output of deep cerebellar nuclear neurons to thalamic targets: K V 1 channel governs cerebellar output to thalamus. J Physiol 591:1771\u20131791. https:\/\/doi.org\/10.1113\/jphysiol.2012.249706","journal-title":"J Physiol"},{"key":"4088_CR82","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1152\/jn.00691.2017","volume":"120","author":"D Guan","year":"2018","unstructured":"Guan D, Pathak D, Foehring RC (2018) Functional roles of Kv1-mediated currents in genetically identified subtypes of pyramidal neurons in layer 5 of mouse somatosensory cortex. J Neurophysiol 120:394\u2013408. https:\/\/doi.org\/10.1152\/jn.00691.2017","journal-title":"J Neurophysiol"},{"key":"4088_CR83","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1046\/j.1432-1327.1999.00494.x","volume":"263","author":"FC Wang","year":"1999","unstructured":"Wang FC, Bell N, Reid P et al (1999) Identification of residues in dendrotoxin K responsible for its discrimination between neuronal K+ channels containing Kv1.1 and 1.2 alpha subunits. Eur J Biochem 263:222\u2013229. https:\/\/doi.org\/10.1046\/j.1432-1327.1999.00494.x","journal-title":"Eur J Biochem"},{"key":"4088_CR84","doi-asserted-by":"publisher","first-page":"3065","DOI":"10.2174\/0929867043363820","volume":"11","author":"AL Harvey","year":"2004","unstructured":"Harvey AL, Robertson B (2004) Dendrotoxins: structure-activity relationships and effects on potassium ion channels. CMC 11:3065\u20133072. https:\/\/doi.org\/10.2174\/0929867043363820","journal-title":"CMC"},{"key":"4088_CR85","doi-asserted-by":"publisher","first-page":"3346","DOI":"10.1523\/JNEUROSCI.3245-17.2018","volume":"38","author":"L Zhou","year":"2018","unstructured":"Zhou L, Zhou L, Su L et al (2018) Celecoxib ameliorates seizure susceptibility in autosomal dominant lateral temporal epilepsy. J Neurosci 38:3346\u20133357. https:\/\/doi.org\/10.1523\/JNEUROSCI.3245-17.2018","journal-title":"J Neurosci"},{"key":"4088_CR86","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.neulet.2019.04.012","volume":"704","author":"E Lancaster","year":"2019","unstructured":"Lancaster E, Burnor E, Zhang J, Lancaster E (2019) ADAM23 is a negative regulator of Kv1.1\/Kv1.4 potassium currents. Neurosci Lett 704:159\u2013163. https:\/\/doi.org\/10.1016\/j.neulet.2019.04.012","journal-title":"Neurosci Lett"},{"key":"4088_CR87","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2021.108569","volume":"195","author":"JM Henley","year":"2021","unstructured":"Henley JM, Nair JD, Seager R et al (2021) Kainate and AMPA receptors in epilepsy: cell biology, signalling pathways and possible crosstalk. Neuropharmacology 195:108569. https:\/\/doi.org\/10.1016\/j.neuropharm.2021.108569","journal-title":"Neuropharmacology"},{"key":"4088_CR88","doi-asserted-by":"publisher","first-page":"13902","DOI":"10.1073\/pnas.172511199","volume":"99","author":"E Schnell","year":"2002","unstructured":"Schnell E, Sizemore M, Karimzadegan S et al (2002) Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor number. Proc Natl Acad Sci U S A 99:13902\u201313907. https:\/\/doi.org\/10.1073\/pnas.172511199","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4088_CR89","doi-asserted-by":"publisher","first-page":"5567","DOI":"10.1021\/bi0511989","volume":"45","author":"L von Ossowski","year":"2006","unstructured":"von Ossowski L, Tossavainen H, von Ossowski I et al (2006) Peptide binding and NMR analysis of the interaction between SAP97 PDZ2 and GluR-A: potential involvement of a disulfide bond. Biochemistry 45:5567\u20135575. https:\/\/doi.org\/10.1021\/bi0511989","journal-title":"Biochemistry"},{"key":"4088_CR90","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/ng0595-56","volume":"10","author":"R Ottman","year":"1995","unstructured":"Ottman R, Risch N, Hauser WA et al (1995) Localization of a gene for partial epilepsy to chromosome 10q. Nat Genet 10:56\u201360. https:\/\/doi.org\/10.1038\/ng0595-56","journal-title":"Nat Genet"},{"key":"4088_CR91","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1016\/j.ajhg.2015.04.020","volume":"96","author":"E Dazzo","year":"2015","unstructured":"Dazzo E, Fanciulli M, Serioli E et al (2015) Heterozygous reelin mutations cause autosomal-dominant lateral temporal epilepsy. Am J Hum Genet 96:992\u20131000. https:\/\/doi.org\/10.1016\/j.ajhg.2015.04.020","journal-title":"Am J Hum Genet"},{"key":"4088_CR92","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1046\/j.1528-1157.2003.20003.x","volume":"44","author":"R Michelucci","year":"2003","unstructured":"Michelucci R, Poza JJ, Sofia V et al (2003) Autosomal dominant lateral temporal epilepsy: clinical spectrum, new epitempin mutations, and genetic heterogeneity in seven European families: familial lateral temporal epilepsy. Epilepsia 44:1289\u20131297. https:\/\/doi.org\/10.1046\/j.1528-1157.2003.20003.x","journal-title":"Epilepsia"},{"key":"4088_CR93","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1111\/epi.12194","volume":"54","author":"R Michelucci","year":"2013","unstructured":"Michelucci R, Pasini E, Malacrida S et al (2013) Low penetrance of autosomal dominant lateral temporal epilepsy in Italian families without LGI1 mutations. Epilepsia 54:1288\u20131297. https:\/\/doi.org\/10.1111\/epi.12194","journal-title":"Epilepsia"},{"key":"4088_CR94","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1111\/epi.12560","volume":"55","author":"F Bisulli","year":"2014","unstructured":"Bisulli F, Naldi I, Baldassari S et al (2014) Autosomal dominant partial epilepsy with auditory features: a new locus on chromosome 19q13.11-q13.31. Epilepsia 55:841\u2013848. https:\/\/doi.org\/10.1111\/epi.12560","journal-title":"Epilepsia"},{"key":"4088_CR95","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.jneumeth.2015.06.003","volume":"260","author":"M Boillot","year":"2016","unstructured":"Boillot M, Baulac S (2016) Genetic models of focal epilepsies. J Neurosci Methods 260:132\u2013143. https:\/\/doi.org\/10.1016\/j.jneumeth.2015.06.003","journal-title":"J Neurosci Methods"},{"key":"4088_CR96","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1007\/s00018-019-03269-0","volume":"77","author":"A Yamagata","year":"2020","unstructured":"Yamagata A, Fukai S (2020) Insights into the mechanisms of epilepsy from structural biology of LGI1\u2013ADAM22. Cell Mol Life Sci 77:267\u2013274. https:\/\/doi.org\/10.1007\/s00018-019-03269-0","journal-title":"Cell Mol Life Sci"},{"key":"4088_CR97","doi-asserted-by":"publisher","first-page":"3546","DOI":"10.1093\/hmg\/dds184","volume":"21","author":"S Baulac","year":"2012","unstructured":"Baulac S, Ishida S, Mashimo T et al (2012) A rat model for LGI1-related epilepsies. Hum Mol Genet 21:3546\u20133557. https:\/\/doi.org\/10.1093\/hmg\/dds184","journal-title":"Hum Mol Genet"},{"key":"4088_CR98","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1212\/WNL.0b013e318212ab2e","volume":"76","author":"P Striano","year":"2011","unstructured":"Striano P, Busolin G, Santulli L et al (2011) Familial temporal lobe epilepsy with psychic auras associated with a novel LGI1 mutation. Neurology 76:1173\u20131176. https:\/\/doi.org\/10.1212\/WNL.0b013e318212ab2e","journal-title":"Neurology"},{"key":"4088_CR99","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1212\/01.wnl.0000323926.77565.ee","volume":"71","author":"MJ Rosanoff","year":"2008","unstructured":"Rosanoff MJ, Ottman R (2008) Penetrance of LGI1 mutations in autosomal dominant partial epilepsy with auditory features. Neurology 71:567\u2013571. https:\/\/doi.org\/10.1212\/01.wnl.0000323926.77565.ee","journal-title":"Neurology"},{"key":"4088_CR100","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1002\/humu.20925","volume":"30","author":"C Nobile","year":"2009","unstructured":"Nobile C, Michelucci R, Andreazza S et al (2009) LGI1 mutations in autosomal dominant and sporadic lateral temporal epilepsy. Hum Mutat 30:530\u2013536. https:\/\/doi.org\/10.1002\/humu.20925","journal-title":"Hum Mutat"},{"key":"4088_CR101","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1093\/brain\/awh077","volume":"127","author":"A Vincent","year":"2004","unstructured":"Vincent A, Buckley C, Schott JM et al (2004) Potassium channel antibody-associated encephalopathy: a potentially immunotherapy-responsive form of limbic encephalitis. Brain 127:701\u2013712. https:\/\/doi.org\/10.1093\/brain\/awh077","journal-title":"Brain"},{"key":"4088_CR102","doi-asserted-by":"publisher","first-page":"e2185","DOI":"10.1212\/WNL.0000000000007475","volume":"92","author":"MAAM de Bruijn","year":"2019","unstructured":"de Bruijn MAAM, van Sonderen A, van Coevorden-Hameete MH et al (2019) Evaluation of seizure treatment in anti-LGI1, anti-NMDAR, and anti-GABA B R encephalitis. Neurology 92:e2185\u2013e2196. https:\/\/doi.org\/10.1212\/WNL.0000000000007475","journal-title":"Neurology"},{"key":"4088_CR103","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1002\/acn3.51137","volume":"7","author":"C Shen","year":"2020","unstructured":"Shen C, Fang G, Yang F et al (2020) Seizures and risk of epilepsy in anti-NMDAR, anti-LGI1, and anti-GABABR encephalitis. Ann Clin Transl Neurol 7:1392\u20131399. https:\/\/doi.org\/10.1002\/acn3.51137","journal-title":"Ann Clin Transl Neurol"},{"key":"4088_CR104","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.seizure.2021.02.010","volume":"86","author":"M Ilyas-Feldmann","year":"2021","unstructured":"Ilyas-Feldmann M, Pr\u00fc\u00df H, Holtkamp M (2021) Long-term seizure outcome and antiseizure medication use in autoimmune encephalitis. Seizure 86:138\u2013143. https:\/\/doi.org\/10.1016\/j.seizure.2021.02.010","journal-title":"Seizure"},{"key":"4088_CR105","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.642078","volume":"12","author":"S Qiao","year":"2021","unstructured":"Qiao S, Wu H-K, Liu L-L et al (2021) Characteristics and prognosis of autoimmune encephalitis in the East of China: a multi-center study. Front Neurol 12:642078. https:\/\/doi.org\/10.3389\/fneur.2021.642078","journal-title":"Front Neurol"},{"key":"4088_CR106","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.621599","volume":"12","author":"W Shan","year":"2021","unstructured":"Shan W, Yang H, Wang Q (2021) Neuronal surface antibody-medicated autoimmune encephalitis (limbic encephalitis) in China: a multiple-center retrospective study. Front Immunol 12:621599. https:\/\/doi.org\/10.3389\/fimmu.2021.621599","journal-title":"Front Immunol"},{"key":"4088_CR107","doi-asserted-by":"publisher","DOI":"10.1684\/epd.2021.1355","author":"L Cousyn","year":"2021","unstructured":"Cousyn L, Lambrecq V, Houot M et al (2021) Seizures in autoimmune encephalitis: specific features from a systematic comparative study. Epileptic Disord. https:\/\/doi.org\/10.1684\/epd.2021.1355","journal-title":"Epileptic Disord"},{"key":"4088_CR108","doi-asserted-by":"publisher","first-page":"203","DOI":"10.2147\/NDT.S292343","volume":"17","author":"S Qiao","year":"2021","unstructured":"Qiao S, Wu H, Liu L et al (2021) Clinical features and long-term outcomes of anti-leucine-rich glioma-inactivated 1 encephalitis: a multi-center study. NDT 17:203\u2013212. https:\/\/doi.org\/10.2147\/NDT.S292343","journal-title":"NDT"},{"key":"4088_CR109","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2021.108159","volume":"122","author":"N Lin","year":"2021","unstructured":"Lin N, Liu Q, Chen J et al (2021) Long-term seizure outcomes in patients with anti-leucine-rich glioma-inactivated 1 encephalitis. Epilepsy Behav 122:108159. https:\/\/doi.org\/10.1016\/j.yebeh.2021.108159","journal-title":"Epilepsy Behav"},{"key":"4088_CR110","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.674368","volume":"12","author":"T-R Li","year":"2021","unstructured":"Li T-R, Zhang Y-D, Wang Q et al (2021) Clinical characteristics and long-term prognosis of anti-LGI1 encephalitis: a single-center cohort study in Beijing. China Front Neurol 12:674368. https:\/\/doi.org\/10.3389\/fneur.2021.674368","journal-title":"China Front Neurol"},{"key":"4088_CR111","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2021.106542","volume":"203","author":"Q Zhao","year":"2021","unstructured":"Zhao Q, Sun L, Zhao D et al (2021) Clinical features of anti-leucine-rich glioma-inactivated 1 encephalitis in northeast China. Clin Neurol Neurosurg 203:106542. https:\/\/doi.org\/10.1016\/j.clineuro.2021.106542","journal-title":"Clin Neurol Neurosurg"},{"key":"4088_CR112","doi-asserted-by":"publisher","first-page":"1692","DOI":"10.1212\/WNL.0000000000002637","volume":"86","author":"A van Sonderen","year":"2016","unstructured":"van Sonderen A, Schreurs MWJ, de Bruijn MAAM et al (2016) The relevance of VGKC positivity in the absence of LGI1 and Caspr2 antibodies. Neurology 86:1692\u20131699. https:\/\/doi.org\/10.1212\/WNL.0000000000002637","journal-title":"Neurology"},{"key":"4088_CR113","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1001\/jamaneurol.2021.0477","volume":"78","author":"SNM Binks","year":"2021","unstructured":"Binks SNM, Veldsman M, Easton A et al (2021) Residual fatigue and cognitive deficits in patients after leucine-rich glioma-inactivated 1 antibody encephalitis. JAMA Neurol 78:617. https:\/\/doi.org\/10.1001\/jamaneurol.2021.0477","journal-title":"JAMA Neurol"},{"key":"4088_CR114","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1002\/ana.24860","volume":"81","author":"T-J Kim","year":"2017","unstructured":"Kim T-J, Lee S-T, Moon J et al (2017) Anti-LGI1 encephalitis is associated with unique HLA subtypes: HLA subtypes in anti-LGI1 encephalitis. Ann Neurol 81:183\u2013192. https:\/\/doi.org\/10.1002\/ana.24860","journal-title":"Ann Neurol"},{"key":"4088_CR115","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1002\/ana.24858","volume":"81","author":"A van Sonderen","year":"2017","unstructured":"van Sonderen A, Roelen DL, Stoop JA et al (2017) Anti-LGI1 encephalitis is strongly associated with HLA-DR7 and HLA-DRB4: anti-LGI1 encephalitis. Ann Neurol 81:193\u2013198. https:\/\/doi.org\/10.1002\/ana.24858","journal-title":"Ann Neurol"},{"key":"4088_CR116","doi-asserted-by":"publisher","first-page":"2263","DOI":"10.1093\/brain\/awy109","volume":"141","author":"S Binks","year":"2018","unstructured":"Binks S, Varley J, Lee W et al (2018) Distinct HLA associations of LGI1 and CASPR2-antibody diseases. Brain 141:2263\u20132271. https:\/\/doi.org\/10.1093\/brain\/awy109","journal-title":"Brain"},{"key":"4088_CR117","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000974","volume":"8","author":"S Mu\u00f1iz-Castrillo","year":"2021","unstructured":"Mu\u00f1iz-Castrillo S, Haesebaert J, Thomas L et al (2021) Clinical and prognostic value of immunogenetic characteristics in anti-LGI1 encephalitis. Neurol Neuroimmunol Neuroinflamm 8:e974. https:\/\/doi.org\/10.1212\/NXI.0000000000000974","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"key":"4088_CR118","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.clinph.2017.10.014","volume":"129","author":"R Wennberg","year":"2018","unstructured":"Wennberg R, Steriade C, Chen R, Andrade D (2018) Frontal infraslow activity marks the motor spasms of anti-LGI1 encephalitis. Clin Neurophysiol 129:59\u201368. https:\/\/doi.org\/10.1016\/j.clinph.2017.10.014","journal-title":"Clin Neurophysiol"},{"key":"4088_CR119","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.seizure.2019.12.023","volume":"76","author":"X Liu","year":"2020","unstructured":"Liu X, Han Y, Yang L et al (2020) The exploration of the spectrum of motor manifestations of anti-LGI1 encephalitis beyond FBDS. Seizure 76:22\u201327. https:\/\/doi.org\/10.1016\/j.seizure.2019.12.023","journal-title":"Seizure"},{"key":"4088_CR120","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000161","volume":"2","author":"EP Flanagan","year":"2015","unstructured":"Flanagan EP, Kotsenas AL, Britton JW et al (2015) Basal ganglia T1 hyperintensity in LGI1-autoantibody faciobrachial dystonic seizures. Neurol Neuroimmunol Neuroinflamm 2:e161. https:\/\/doi.org\/10.1212\/NXI.0000000000000161","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"key":"4088_CR121","doi-asserted-by":"publisher","first-page":"418","DOI":"10.3389\/fneur.2020.00418","volume":"11","author":"X Liu","year":"2020","unstructured":"Liu X, Shan W, Zhao X et al (2020) The clinical value of 18F-FDG-PET in autoimmune encephalitis associated with LGI1 antibody. Front Neurol 11:418. https:\/\/doi.org\/10.3389\/fneur.2020.00418","journal-title":"Front Neurol"},{"key":"4088_CR122","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1007\/s00702-021-02299-y","volume":"128","author":"N Br\u00fcggemann","year":"2021","unstructured":"Br\u00fcggemann N (2021) Contemporary functional neuroanatomy and pathophysiology of dystonia. J Neural Transm (Vienna) 128:499\u2013508. https:\/\/doi.org\/10.1007\/s00702-021-02299-y","journal-title":"J Neural Transm (Vienna)"},{"key":"4088_CR123","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1111\/ene.13324","volume":"24","author":"M Celicanin","year":"2017","unstructured":"Celicanin M, Blaabjerg M, Maersk-Moller C et al (2017) Autoimmune encephalitis associated with voltage-gated potassium channels-complex and leucine-rich glioma-inactivated 1 antibodies - a national cohort study. Eur J Neurol 24:999\u20131005. https:\/\/doi.org\/10.1111\/ene.13324","journal-title":"Eur J Neurol"},{"key":"4088_CR124","doi-asserted-by":"publisher","first-page":"852","DOI":"10.3389\/fneur.2020.00852","volume":"11","author":"H Hang","year":"2020","unstructured":"Hang H, Zhang J, Chen D et al (2020) Clinical characteristics of cognitive impairment and 1-year outcome in patients with anti-LGI1 antibody encephalitis. Front Neurol 11:852. https:\/\/doi.org\/10.3389\/fneur.2020.00852","journal-title":"Front Neurol"},{"key":"4088_CR125","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26189","author":"S Ramanathan","year":"2021","unstructured":"Ramanathan S, Tseng M, Davies AJ et al (2021) LGI1- versus CASPR2-antibody neuropathic pain: clinical and biological comparisons. Ann Neurol. https:\/\/doi.org\/10.1002\/ana.26189","journal-title":"Ann Neurol"},{"key":"4088_CR126","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1212\/WNL.0000000000003173","volume":"87","author":"A van Sonderen","year":"2016","unstructured":"van Sonderen A, Thijs RD, Coenders EC et al (2016) Anti-LGI1 encephalitis: clinical syndrome and long-term follow-up. Neurology 87:1449\u20131456. https:\/\/doi.org\/10.1212\/WNL.0000000000003173","journal-title":"Neurology"},{"key":"4088_CR127","doi-asserted-by":"publisher","DOI":"10.1111\/ane.13503","author":"W Chen","year":"2021","unstructured":"Chen W, Wang M, Gao L et al (2021) Neurofunctional outcomes in patients with anti-leucine-rich glioma inactivated 1 encephalitis. Acta Neurol Scand. https:\/\/doi.org\/10.1111\/ane.13503","journal-title":"Acta Neurol Scand"},{"key":"4088_CR128","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012465","author":"KM Smith","year":"2021","unstructured":"Smith KM, Dubey D, Liebo GB et al (2021) Clinical course and features of seizures associated with LGI1-antibody encephalitis. Neurology. https:\/\/doi.org\/10.1212\/WNL.0000000000012465","journal-title":"Neurology"},{"key":"4088_CR129","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1212\/WNL.0000000000003009","volume":"87","author":"H Ari\u00f1o","year":"2016","unstructured":"Ari\u00f1o H, Armangu\u00e9 T, Petit-Pedrol M et al (2016) Anti-LGI1\u2013associated cognitive impairment: presentation and long-term outcome. Neurology 87:759\u2013765. https:\/\/doi.org\/10.1212\/WNL.0000000000003009","journal-title":"Neurology"},{"key":"4088_CR130","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1093\/brain\/awx323","volume":"141","author":"J Thompson","year":"2018","unstructured":"Thompson J, Bi M, Murchison AG et al (2018) The importance of early immunotherapy in patients with faciobrachial dystonic seizures. Brain 141:348\u2013356. https:\/\/doi.org\/10.1093\/brain\/awx323","journal-title":"Brain"},{"key":"4088_CR131","doi-asserted-by":"publisher","first-page":"2101","DOI":"10.1007\/s00415-020-09814-3","volume":"267","author":"CG Bien","year":"2020","unstructured":"Bien CG, Bien CI, Dogan Onugoren M et al (2020) Routine diagnostics for neural antibodies, clinical correlates, treatment and functional outcome. J Neurol 267:2101\u20132114. https:\/\/doi.org\/10.1007\/s00415-020-09814-3","journal-title":"J Neurol"},{"key":"4088_CR132","doi-asserted-by":"publisher","first-page":"97","DOI":"10.3389\/fimmu.2018.00097","volume":"9","author":"I Koneczny","year":"2018","unstructured":"Koneczny I (2018) A new classification system for IgG4 autoantibodies. Front Immunol 9:97. https:\/\/doi.org\/10.3389\/fimmu.2018.00097","journal-title":"Front Immunol"},{"key":"4088_CR133","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1093\/brain\/awaa104","volume":"143","author":"M Ramberger","year":"2020","unstructured":"Ramberger M, Berretta A, Tan JMM et al (2020) Distinctive binding properties of human monoclonal LGI1 autoantibodies determine pathogenic mechanisms. Brain 143:1731\u20131745. https:\/\/doi.org\/10.1093\/brain\/awaa104","journal-title":"Brain"},{"key":"4088_CR134","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1016\/j.ijdevneu.2009.08.016","volume":"27","author":"I Gonz\u00e1lez-Burgos","year":"2009","unstructured":"Gonz\u00e1lez-Burgos I, Vel\u00e1zquez-Zamora DA, Beas-Z\u00e1rate C (2009) Damage and plasticity in adult rat hippocampal trisynaptic circuit neurons after neonatal exposure to glutamate excitotoxicity. Int J Dev Neurosci 27:741\u2013745. https:\/\/doi.org\/10.1016\/j.ijdevneu.2009.08.016","journal-title":"Int J Dev Neurosci"},{"key":"4088_CR135","doi-asserted-by":"publisher","first-page":"3151","DOI":"10.1093\/brain\/awt212","volume":"136","author":"SR Irani","year":"2013","unstructured":"Irani SR, Stagg CJ, Schott JM et al (2013) Faciobrachial dystonic seizures: the influence of immunotherapy on seizure control and prevention of cognitive impairment in a broadening phenotype. Brain 136:3151\u20133162. https:\/\/doi.org\/10.1093\/brain\/awt212","journal-title":"Brain"},{"key":"4088_CR136","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1002\/epi4.12226","volume":"3","author":"AM Feyissa","year":"2018","unstructured":"Feyissa AM, Lamb C, Pittock SJ et al (2018) Antiepileptic drug therapy in autoimmune epilepsy associated with antibodies targeting the leucine-rich glioma-inactivated protein 1. Epilepsia Open 3:348\u2013356. https:\/\/doi.org\/10.1002\/epi4.12226","journal-title":"Epilepsia Open"},{"key":"4088_CR137","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1002\/ana.25655","volume":"87","author":"D Dubey","year":"2020","unstructured":"Dubey D, Britton J, McKeon A et al (2020) Randomized placebo-controlled trial of intravenous immunoglobulin in autoimmune LGI1\/CASPR2 epilepsy. Ann Neurol 87:313\u2013323. https:\/\/doi.org\/10.1002\/ana.25655","journal-title":"Ann Neurol"},{"key":"4088_CR138","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awy253","author":"M Petit-Pedrol","year":"2018","unstructured":"Petit-Pedrol M, Sell J, Planagum\u00e0 J et al (2018) LGI1 antibodies alter Kv1.1 and AMPA receptors changing synaptic excitability, plasticity and memory. Brain. https:\/\/doi.org\/10.1093\/brain\/awy253","journal-title":"Brain"},{"key":"4088_CR139","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.652820","volume":"12","author":"T-Y Zhang","year":"2021","unstructured":"Zhang T-Y, Cai M-T, Zheng Y et al (2021) Anti-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor encephalitis: a review. Front Immunol 12:652820. https:\/\/doi.org\/10.3389\/fimmu.2021.652820","journal-title":"Front Immunol"}],"container-title":["Cellular and Molecular Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-021-04088-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00018-021-04088-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-021-04088-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T12:07:50Z","timestamp":1645704470000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00018-021-04088-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,30]]},"references-count":139,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["4088"],"URL":"https:\/\/doi.org\/10.1007\/s00018-021-04088-y","relation":{},"ISSN":["1420-682X","1420-9071"],"issn-type":[{"value":"1420-682X","type":"print"},{"value":"1420-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,30]]},"assertion":[{"value":"31 August 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 December 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 December 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 December 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"V.N. reports personal fees from UCB, Liva Nova, and EISAI, outside the submitted work. The other authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The authors affirm that patients provided informed consent for publication of the images in Fig.\u00a0\n                      \n                      and in Online Resource 1.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"All authors gave their consent for publication.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"16"}}