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Mol. Life Sci."],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chronic liver diseases represent a burgeoning health problem affecting billions of people worldwide. The insufficient performance of current minimally invasive tools is recognised as a significant barrier to the clinical management of these conditions. Extracellular vesicles (EVs) have emerged as a rich source of circulating biomarkers closely linked to pathological processes in originating tissues. Here, we summarise the contribution of EVs to normal liver function and to chronic liver pathologies; and explore the use of circulating EV biomarkers, with a particular focus on techniques to isolate and analyse cell- or tissue-specific EVs. Such approaches present a novel strategy to inform disease status and monitor changes in response to treatment in a minimally invasive manner. Emerging technologies that support the selective isolation and analysis of circulating EVs derived only from hepatic cells, have driven recent advancements in EV-based biomarker platforms for chronic liver diseases and show promise to bring these techniques to clinical settings.<\/jats:p>","DOI":"10.1007\/s00018-022-04256-8","type":"journal-article","created":{"date-parts":[[2022,4,10]],"date-time":"2022-04-10T05:02:35Z","timestamp":1649566955000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Circulating cell-specific extracellular vesicles as biomarkers for the diagnosis and monitoring of chronic liver diseases"],"prefix":"10.1007","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3303-1666","authenticated-orcid":false,"given":"Lauren A.","family":"Newman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Muller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8946-3954","authenticated-orcid":false,"given":"Andrew","family":"Rowland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,4,10]]},"reference":[{"issue":"1","key":"4256_CR1","doi-asserted-by":"publisher","first-page":"1461505","DOI":"10.1080\/20013078.2018.1461505","volume":"7","author":"L Chen","year":"2018","unstructured":"Chen L, Chen R, Kemper S, Cong M, You H, Brigstock DR (2018) Therapeutic effects of serum extracellular vesicles in liver fibrosis. 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