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Mol. Life Sci."],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Endocytosis is controlled by a well-orchestrated molecular machinery, where the individual players as well as their precise interactions are not fully understood. We now show that syndapin I\/PACSIN 1 is expressed in pancreatic \u03b2 cells and that its knockdown abrogates \u03b2 cell endocytosis leading to disturbed plasma membrane protein homeostasis, as exemplified by an elevated density of L-type Ca<jats:sup>2+<\/jats:sup> channels. Intriguingly, inositol hexakisphosphate (InsP<jats:sub>6<\/jats:sub>) activates casein kinase 2 (CK2) that phosphorylates syndapin I\/PACSIN 1, thereby promoting interactions between syndapin I\/PACSIN 1 and neural Wiskott\u2013Aldrich syndrome protein (N-WASP) and driving \u03b2 cell endocytosis. Dominant-negative interference with endogenous syndapin I\/PACSIN 1 protein complexes, by overexpression of the syndapin I\/PACSIN 1 SH3 domain, decreases InsP<jats:sub>6<\/jats:sub>-stimulated endocytosis. InsP<jats:sub>6<\/jats:sub> thus promotes syndapin I\/PACSIN 1 priming by CK2-dependent phosphorylation, which endows the syndapin I\/PACSIN 1 SH3 domain with the capability to interact with the endocytic machinery and thereby initiate endocytosis, as exemplified in \u03b2 cells.<\/jats:p>","DOI":"10.1007\/s00018-022-04305-2","type":"journal-article","created":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T17:23:07Z","timestamp":1652116987000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Inositol hexakisphosphate primes syndapin I\/PACSIN 1 activation in endocytosis"],"prefix":"10.1007","volume":"79","author":[{"given":"Yue","family":"Shi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaixuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael M.","family":"Kessels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Britta","family":"Qualmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per-Olof","family":"Berggren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7470-7197","authenticated-orcid":false,"given":"Shao-Nian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,5,9]]},"reference":[{"key":"4305_CR1","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1016\/j.cell.2006.02.025","volume":"124","author":"S Polo","year":"2006","unstructured":"Polo S, Di Fiore PP (2006) Endocytosis conducts the cell signaling orchestra. 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