{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T06:18:14Z","timestamp":1778134694767,"version":"3.51.4"},"reference-count":208,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2022,8,6]],"date-time":"2022-08-06T00:00:00Z","timestamp":1659744000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,8,6]],"date-time":"2022-08-06T00:00:00Z","timestamp":1659744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32021005"],"award-info":[{"award-number":["32021005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31820103010"],"award-info":[{"award-number":["31820103010"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015601","name":"Collaborative Innovationcenter of Food Safety and Quality Control in Jiangsu Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015601","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell. Mol. Life Sci."],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1007\/s00018-022-04498-6","type":"journal-article","created":{"date-parts":[[2022,8,6]],"date-time":"2022-08-06T05:02:51Z","timestamp":1659762171000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Microbiota-assisted therapy for systemic inflammatory arthritis: advances and mechanistic insights"],"prefix":"10.1007","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4199-7164","authenticated-orcid":false,"given":"Bowen","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1347-3718","authenticated-orcid":false,"given":"Bo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianxin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. Paul","family":"Ross","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Stanton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,8,6]]},"reference":[{"key":"4498_CR1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1002533","volume":"14","author":"R Sender","year":"2016","unstructured":"Sender R, Fuchs S, Milo R (2016) Revised estimates for the number of human and bacteria cells in the body. PLoS Biol 14:e1002533. https:\/\/doi.org\/10.1371\/journal.pbio.1002533","journal-title":"PLoS Biol"},{"key":"4498_CR2","doi-asserted-by":"publisher","first-page":"1915","DOI":"10.1126\/science.1104816","volume":"307","author":"F B\u00e4ckhed","year":"2005","unstructured":"B\u00e4ckhed F, Ley RE, Sonnenburg JL et al (2005) Host-bacterial mutualism in the human intestine. Science 307:1915. https:\/\/doi.org\/10.1126\/science.1104816","journal-title":"Science"},{"key":"4498_CR3","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1016\/j.chom.2021.05.008","volume":"29","author":"F Hildebrand","year":"2021","unstructured":"Hildebrand F, Gossmann TI, Frioux C et al (2021) Dispersal strategies shape persistence and evolution of human gut bacteria. Cell Host Microbe 29:1167\u20131176","journal-title":"Cell Host Microbe"},{"key":"4498_CR4","doi-asserted-by":"publisher","first-page":"2302","DOI":"10.1016\/j.cell.2021.03.024","volume":"184","author":"L Chen","year":"2021","unstructured":"Chen L, Wang D, Garmaeva S et al (2021) The long-term genetic stability and individual specificity of the human gut microbiome. Cell 184:2302-2315.e2312. https:\/\/doi.org\/10.1016\/j.cell.2021.03.024","journal-title":"Cell"},{"key":"4498_CR5","doi-asserted-by":"publisher","first-page":"3063","DOI":"10.1038\/s41467-021-23265-y","volume":"12","author":"Y Wu","year":"2021","unstructured":"Wu Y, Jiao N, Zhu R et al (2021) Identification of microbial markers across populations in early detection of colorectal cancer. Nat Commun 12:3063. https:\/\/doi.org\/10.1038\/s41467-021-23265-y","journal-title":"Nat Commun"},{"key":"4498_CR6","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1016\/j.cell.2020.05.036","volume":"181","author":"S Alavi","year":"2020","unstructured":"Alavi S, Mitchell JD, Cho JY et al (2020) Interpersonal gut microbiome variation drives susceptibility and resistance to cholera infection. Cell 181:1533-1546.e1513. https:\/\/doi.org\/10.1016\/j.cell.2020.05.036","journal-title":"Cell"},{"key":"4498_CR7","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.05.054","author":"J Miyoshi","year":"2021","unstructured":"Miyoshi J, Miyoshi S, Delmont TO et al (2021) Early-life microbial restitution reduces colitis risk promoted by antibiotic-induced gut dysbiosis in IL-10-\/- mice. Gastroenterology. https:\/\/doi.org\/10.1053\/j.gastro.2021.05.054","journal-title":"Gastroenterology"},{"key":"4498_CR8","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1186\/s40168-020-00940-8","volume":"8","author":"M Selma-Royo","year":"2020","unstructured":"Selma-Royo M, Calatayud Arroyo M, Garc\u00eda-Mantrana I et al (2020) Perinatal environment shapes microbiota colonization and infant growth: impact on host response and intestinal function. Microbiome 8:167. https:\/\/doi.org\/10.1186\/s40168-020-00940-8","journal-title":"Microbiome"},{"key":"4498_CR9","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1038\/s41586-019-1238-8","volume":"569","author":"LM Proctor","year":"2019","unstructured":"Proctor LM, Creasy HH, Fettweis JM et al (2019) The integrative human microbiome project. Nature 569:641\u2013648. https:\/\/doi.org\/10.1038\/s41586-019-1238-8","journal-title":"Nature"},{"key":"4498_CR10","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1001\/jama.2019.19602","volume":"323","author":"CP Harkins","year":"2020","unstructured":"Harkins CP, Kong HH, Segre JA (2020) Manipulating the human microbiome to manage disease. JAMA 323:303\u2013304. https:\/\/doi.org\/10.1001\/jama.2019.19602","journal-title":"JAMA"},{"key":"4498_CR11","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j5145","volume":"360","author":"JC Clemente","year":"2018","unstructured":"Clemente JC, Manasson J, Scher JU (2018) The role of the gut microbiome in systemic inflammatory disease. BMJ 360:j5145. https:\/\/doi.org\/10.1136\/bmj.j5145","journal-title":"BMJ"},{"key":"4498_CR12","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1016\/j.cmet.2020.03.003","volume":"31","author":"EC Rosser","year":"2020","unstructured":"Rosser EC, Piper CJM, Matei DE et al (2020) Microbiota-derived metabolites suppress arthritis by amplifying Aryl-hydrocarbon receptor activation in regulatory B cells. Cell Metab 31:837-851.e810. https:\/\/doi.org\/10.1016\/j.cmet.2020.03.003","journal-title":"Cell Metab"},{"key":"4498_CR13","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1186\/s13059-017-1271-6","volume":"18","author":"C Wen","year":"2017","unstructured":"Wen C, Zheng Z, Shao T et al (2017) Quantitative metagenomics reveals unique gut microbiome biomarkers in ankylosing spondylitis. Genome Biol 18:142. https:\/\/doi.org\/10.1186\/s13059-017-1271-6","journal-title":"Genome Biol"},{"key":"4498_CR14","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/s41584-020-0454-9","volume":"16","author":"E Gracey","year":"2020","unstructured":"Gracey E, Vereecke L, McGovern D et al (2020) Revisiting the gut\u2013joint axis: links between gut inflammation and spondyloarthritis. Nat Rev Rheumatol 16:415\u2013433. https:\/\/doi.org\/10.1038\/s41584-020-0454-9","journal-title":"Nat Rev Rheumatol"},{"key":"4498_CR15","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.cell.2020.03.007","volume":"181","author":"L Fugger","year":"2020","unstructured":"Fugger L, Jensen LT, Rossjohn J (2020) Challenges, progress, and prospects of developing therapies to treat autoimmune diseases. Cell 181:63\u201380. https:\/\/doi.org\/10.1016\/j.cell.2020.03.007","journal-title":"Cell"},{"key":"4498_CR16","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1016\/j.immuni.2016.03.013","volume":"44","author":"F Teng","year":"2016","unstructured":"Teng F, Klinger CN, Felix KM et al (2016) Gut microbiota drive autoimmune arthritis by promoting differentiation and migration of Peyer\u2019s patch T follicular helper cells. Immunity 44:875\u2013888. https:\/\/doi.org\/10.1016\/j.immuni.2016.03.013","journal-title":"Immunity"},{"key":"4498_CR17","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1007\/s00281-017-0620-6","volume":"39","author":"A Tracy","year":"2017","unstructured":"Tracy A, Buckley CD, Raza K (2017) Pre-symptomatic autoimmunity in rheumatoid arthritis: when does the disease start? Sem Immunopathol 39:423\u2013435. https:\/\/doi.org\/10.1007\/s00281-017-0620-6","journal-title":"Sem Immunopathol"},{"key":"4498_CR18","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1038\/s41584-021-00585-3","volume":"17","author":"MM Zaiss","year":"2021","unstructured":"Zaiss MM, Joyce Wu HJ, Mauro D et al (2021) The gut\u2013joint axis in rheumatoid arthritis. Nat Rev Rheumatol 17:224\u2013237. https:\/\/doi.org\/10.1038\/s41584-021-00585-3","journal-title":"Nat Rev Rheumatol"},{"key":"4498_CR19","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1136\/annrheumdis-2020-219009","volume":"80","author":"R Moentadj","year":"2021","unstructured":"Moentadj R, Wang Y, Bowerman K et al (2021) Streptococcus species enriched in the oral cavity of patients with RA are a source of peptidoglycan-polysaccharide polymers that can induce arthritis in mice. Ann Rheum Dis 80:573. https:\/\/doi.org\/10.1136\/annrheumdis-2020-219009","journal-title":"Ann Rheum Dis"},{"key":"4498_CR20","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2021.1924613","author":"T Behl","year":"2021","unstructured":"Behl T, Mehta K, Sehgal A et al (2021) Exploring the role of polyphenols in rheumatoid arthritis. Crit Rev Food Sci Nutr. https:\/\/doi.org\/10.1080\/10408398.2021.1924613","journal-title":"Crit Rev Food Sci Nutr"},{"key":"4498_CR21","doi-asserted-by":"publisher","first-page":"2950","DOI":"10.1182\/blood-2010-05-284844","volume":"116","author":"MJ Stables","year":"2010","unstructured":"Stables MJ, Newson J, Ayoub SS et al (2010) Priming innate immune responses to infection by cyclooxygenase inhibition kills antibiotic-susceptible and -resistant bacteria. Blood 116:2950\u20132959. https:\/\/doi.org\/10.1182\/blood-2010-05-284844","journal-title":"Blood"},{"key":"4498_CR22","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/nrd1929","volume":"5","author":"JA Mitchell","year":"2006","unstructured":"Mitchell JA, Warner TD (2006) COX isoforms in the cardiovascular system: understanding the activities of non-steroidal anti-inflammatory drugs. Nat Rev Drug Discov 5:75\u201386. https:\/\/doi.org\/10.1038\/nrd1929","journal-title":"Nat Rev Drug Discov"},{"key":"4498_CR23","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1136\/ard.2003.015925","volume":"63","author":"F Richy","year":"2004","unstructured":"Richy F, Bruyere O, Ethgen O et al (2004) Time dependent risk of gastrointestinal complications induced by non-steroidal anti-inflammatory drug use: a consensus statement using a meta-analytic approach. Ann Rheum Dis 63:759. https:\/\/doi.org\/10.1136\/ard.2003.015925","journal-title":"Ann Rheum Dis"},{"key":"4498_CR24","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1053\/j.gastro.2017.10.049","volume":"154","author":"I Bjarnason","year":"2018","unstructured":"Bjarnason I, Scarpignato C, Holmgren E et al (2018) Mechanisms of damage to the gastrointestinal tract from nonsteroidal anti-inflammatory drugs. Gastroenterology 154:500\u2013514. https:\/\/doi.org\/10.1053\/j.gastro.2017.10.049","journal-title":"Gastroenterology"},{"key":"4498_CR25","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1038\/s41569-020-0366-z","volume":"17","author":"A-M Schjerning","year":"2020","unstructured":"Schjerning A-M, McGettigan P, Gislason G (2020) Cardiovascular effects and safety of (non-aspirin) NSAIDs. Nat Rev Cardiol 17:574\u2013584. https:\/\/doi.org\/10.1038\/s41569-020-0366-z","journal-title":"Nat Rev Cardiol"},{"key":"4498_CR26","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/S0140-6736(10)60673-3","volume":"376","author":"FKL Chan","year":"2010","unstructured":"Chan FKL, Lanas A, Scheiman J et al (2010) Celecoxib versus omeprazole and diclofenac in patients with osteoarthritis and rheumatoid arthritis (CONDOR): a randomised trial. Lancet 376:173\u2013179. https:\/\/doi.org\/10.1016\/S0140-6736(10)60673-3","journal-title":"Lancet"},{"key":"4498_CR27","doi-asserted-by":"publisher","first-page":"699","DOI":"10.7326\/0003-4819-124-8-199604150-00001","volume":"124","author":"A van der Heide","year":"1996","unstructured":"van der Heide A, Jacobs JWG, Bijlsma JWJ et al (1996) The effectiveness of early treatment with \u201csecond-line\u201d antirheumatic drugs. Ann Intern Med 124:699\u2013707. https:\/\/doi.org\/10.7326\/0003-4819-124-8-199604150-00001","journal-title":"Ann Intern Med"},{"key":"4498_CR28","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/s41413-020-00112-2","volume":"8","author":"E Macfarlane","year":"2020","unstructured":"Macfarlane E, Seibel MJ, Zhou H (2020) Arthritis and the role of endogenous glucocorticoids. Bone Res 8:33. https:\/\/doi.org\/10.1038\/s41413-020-00112-2","journal-title":"Bone Res"},{"key":"4498_CR29","doi-asserted-by":"publisher","first-page":"870","DOI":"10.7326\/M20-1594","volume":"173","author":"MD George","year":"2020","unstructured":"George MD, Baker JF, Winthrop K et al (2020) Risk for serious infection with low-dose glucocorticoids in patients with rheumatoid arthritis. Ann Intern Med 173:870\u2013878. https:\/\/doi.org\/10.7326\/M20-1594","journal-title":"Ann Intern Med"},{"key":"4498_CR30","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/S0140-6736(20)30636-X","volume":"396","author":"GR Burmester","year":"2020","unstructured":"Burmester GR, Buttgereit F, Bernasconi C et al (2020) Continuing versus tapering glucocorticoids after achievement of low disease activity or remission in rheumatoid arthritis (SEMIRA): a double-blind, multicentre, randomised controlled trial. Lancet 396:267\u2013276. https:\/\/doi.org\/10.1016\/S0140-6736(20)30636-X","journal-title":"Lancet"},{"key":"4498_CR31","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1136\/annrheumdis-2017-212612","volume":"77","author":"S Hilliquin","year":"2018","unstructured":"Hilliquin S, Hugues B, Mitrovic S et al (2018) Ability of disease-modifying antirheumatic drugs to prevent or delay rheumatoid arthritis onset: a systematic literature review and meta-analysis. Ann Rheum Dis 77:1099. https:\/\/doi.org\/10.1136\/annrheumdis-2017-212612","journal-title":"Ann Rheum Dis"},{"key":"4498_CR32","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1136\/annrheumdis-2019-215304","volume":"78","author":"MMA Verhoeven","year":"2019","unstructured":"Verhoeven MMA, de Hair MJH, Tekstra J et al (2019) Initiating tocilizumab, with or without methotrexate, compared with starting methotrexate with prednisone within step-up treatment strategies in early rheumatoid arthritis: an indirect comparison of effectiveness and safety of the U-Act-Early and CAMERA-II treat-to-target trials. Ann Rheum Dis 78:1333. https:\/\/doi.org\/10.1136\/annrheumdis-2019-215304","journal-title":"Ann Rheum Dis"},{"key":"4498_CR33","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1136\/annrheumdis-2017-212628","volume":"77","author":"DMJ Dorleijn","year":"2018","unstructured":"Dorleijn DMJ, Luijsterburg PAJ, Reijman M et al (2018) Intramuscular glucocorticoid injection versus placebo injection in hip osteoarthritis: a 12-week blinded randomised controlled trial. Ann Rheum Dis 77:875. https:\/\/doi.org\/10.1136\/annrheumdis-2017-212628","journal-title":"Ann Rheum Dis"},{"key":"4498_CR34","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/s41584-020-0371-y","volume":"16","author":"RS Hardy","year":"2020","unstructured":"Hardy RS, Raza K, Cooper MS (2020) Therapeutic glucocorticoids: mechanisms of actions in rheumatic diseases. Nat Rev Rheumatol 16:133\u2013144. https:\/\/doi.org\/10.1038\/s41584-020-0371-y","journal-title":"Nat Rev Rheumatol"},{"key":"4498_CR35","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2021-219951","author":"H Nabi","year":"2021","unstructured":"Nabi H, Georgiadis S, Loft AG et al (2021) Comparative effectiveness of two adalimumab biosimilars in 1318 real-world patients with inflammatory rheumatic disease mandated to switch from originator adalimumab: nationwide observational study emulating a randomised clinical trial. Ann Rheum Dis. https:\/\/doi.org\/10.1136\/annrheumdis-2021-219951","journal-title":"Ann Rheum Dis"},{"key":"4498_CR36","doi-asserted-by":"publisher","first-page":"2662","DOI":"10.1161\/CIRCULATIONAHA.107.731877","volume":"117","author":"I Ikonomidis","year":"2008","unstructured":"Ikonomidis I, Lekakis JP, Nikolaou M et al (2008) Inhibition of interleukin-1 by anakinra improves vascular and left ventricular function in patients with rheumatoid arthritis. Circulation 117:2662\u20132669. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.107.731877","journal-title":"Circulation"},{"key":"4498_CR37","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1136\/annrheumdis-2020-217209","volume":"80","author":"DA Pappas","year":"2021","unstructured":"Pappas DA, St John G, Etzel CJ et al (2021) Comparative effectiveness of first-line tumour necrosis factor inhibitor versus non-tumour necrosis factor inhibitor biologics and targeted synthetic agents in patients with rheumatoid arthritis: results from a large US registry study. Ann Rheum Dis 80:96. https:\/\/doi.org\/10.1136\/annrheumdis-2020-217209","journal-title":"Ann Rheum Dis"},{"key":"4498_CR38","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1136\/annrheumdis-2020-218808","volume":"80","author":"X Baraliakos","year":"2021","unstructured":"Baraliakos X, Gossec L, Pournara E et al (2021) Secukinumab in patients with psoriatic arthritis and axial manifestations: results from the double-blind, randomised, phase 3 MAXIMISE trial. Ann Rheum Dis 80:582. https:\/\/doi.org\/10.1136\/annrheumdis-2020-218808","journal-title":"Ann Rheum Dis"},{"key":"4498_CR39","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1001\/jama.2020.4006","volume":"323","author":"AW Armstrong","year":"2020","unstructured":"Armstrong AW, Read C (2020) Pathophysiology, clinical presentation, and treatment of psoriasis: a review. JAMA 323:1945\u20131960. https:\/\/doi.org\/10.1001\/jama.2020.4006","journal-title":"JAMA"},{"key":"4498_CR40","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1002\/acr.23512","volume":"70","author":"A Hresko","year":"2018","unstructured":"Hresko A, Lin T-C, Solomon DH (2018) Medical care costs associated with rheumatoid arthritis in the US: a systematic literature review and meta-analysis. Arthritis Care Res 70:1431\u20131438. https:\/\/doi.org\/10.1002\/acr.23512","journal-title":"Arthritis Care Res"},{"key":"4498_CR41","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1136\/annrheumdis-2019-216068","volume":"79","author":"A Kruglov","year":"2020","unstructured":"Kruglov A, Drutskaya M, Schlienz D et al (2020) Contrasting contributions of TNF from distinct cellular sources in arthritis. Ann Rheum Dis 79:1453. https:\/\/doi.org\/10.1136\/annrheumdis-2019-216068","journal-title":"Ann Rheum Dis"},{"key":"4498_CR42","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6665563","author":"Y Li","year":"2021","unstructured":"Li Y, Zhang S-X, Yin X-F et al (2021) The gut microbiota and its relevance to peripheral lymphocyte subpopulations and cytokines in patients with rheumatoid arthritis. J Immunol Res. https:\/\/doi.org\/10.1155\/2021\/6665563","journal-title":"J Immunol Res"},{"key":"4498_CR43","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1136\/annrheumdis-2019-215763","volume":"79","author":"J Yin","year":"2020","unstructured":"Yin J, Sternes PR, Wang M et al (2020) Shotgun metagenomics reveals an enrichment of potentially cross-reactive bacterial epitopes in ankylosing spondylitis patients, as well as the effects of TNFi therapy upon microbiome composition. Ann Rheum Dis 79:132. https:\/\/doi.org\/10.1136\/annrheumdis-2019-215763","journal-title":"Ann Rheum Dis"},{"key":"4498_CR44","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1111\/1346-8138.14933","volume":"46","author":"J Shapiro","year":"2019","unstructured":"Shapiro J, Cohen NA, Shalev V et al (2019) Psoriatic patients have a distinct structural and functional fecal microbiota compared with controls. J Dermatol 46:595\u2013603. https:\/\/doi.org\/10.1111\/1346-8138.14933","journal-title":"J Dermatol"},{"key":"4498_CR45","doi-asserted-by":"publisher","first-page":"19600","DOI":"10.1073\/pnas.1904779116","volume":"116","author":"SB Kanaan","year":"2019","unstructured":"Kanaan SB, Sensoy O, Yan Z et al (2019) Immunogenicity of a rheumatoid arthritis protective sequence when acquired through microchimerism. Proc Natl Acad Sci 116:19600. https:\/\/doi.org\/10.1073\/pnas.1904779116","journal-title":"Proc Natl Acad Sci"},{"key":"4498_CR46","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1038\/s41467-021-21242-z","volume":"12","author":"Z Ye","year":"2021","unstructured":"Ye Z, Shen Y, Jin K et al (2021) Arachidonic acid-regulated calcium signaling in T cells from patients with rheumatoid arthritis promotes synovial inflammation. Nat Commun 12:907. https:\/\/doi.org\/10.1038\/s41467-021-21242-z","journal-title":"Nat Commun"},{"key":"4498_CR47","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1016\/j.ajhg.2019.08.002","volume":"105","author":"C Terao","year":"2019","unstructured":"Terao C, Brynedal B, Chen Z et al (2019) Distinct HLA associations with rheumatoid arthritis subsets defined by serological subphenotype. Am J Hum Genet 105:616\u2013624. https:\/\/doi.org\/10.1016\/j.ajhg.2019.08.002","journal-title":"Am J Hum Genet"},{"key":"4498_CR48","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1136\/annrheumdis-2017-212365","volume":"77","author":"L Van Hoovels","year":"2018","unstructured":"Van Hoovels L, Jacobs J, Vander Cruyssen B et al (2018) Performance characteristics of rheumatoid factor and anti-cyclic citrullinated peptide antibody assays may impact ACR\/EULAR classification of rheumatoid arthritis. Ann Rheum Dis 77:667. https:\/\/doi.org\/10.1136\/annrheumdis-2017-212365","journal-title":"Ann Rheum Dis"},{"key":"4498_CR49","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1136\/annrheumdis-2019-215463","volume":"78","author":"Y Ishikawa","year":"2019","unstructured":"Ishikawa Y, Ikari K, Hashimoto M et al (2019) Shared epitope defines distinct associations of cigarette smoking with levels of anticitrullinated protein antibody and rheumatoid factor. Ann Rheum Dis 78:1480. https:\/\/doi.org\/10.1136\/annrheumdis-2019-215463","journal-title":"Ann Rheum Dis"},{"key":"4498_CR50","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003432","volume":"17","author":"M Pujades-Rodriguez","year":"2020","unstructured":"Pujades-Rodriguez M, Morgan AW, Cubbon RM et al (2020) Dose-dependent oral glucocorticoid cardiovascular risks in people with immune-mediated inflammatory diseases: a population-based cohort study. PLoS Med 17:e1003432. https:\/\/doi.org\/10.1371\/journal.pmed.1003432","journal-title":"PLoS Med"},{"key":"4498_CR51","doi-asserted-by":"publisher","first-page":"1642","DOI":"10.1002\/art.40917","volume":"71","author":"M Asquith","year":"2019","unstructured":"Asquith M, Sternes PR, Costello M-E et al (2019) HLA alleles associated with risk of ankylosing spondylitis and rheumatoid arthritis influence the gut microbiome. Arthr Rheumatol 71:1642\u20131650. https:\/\/doi.org\/10.1002\/art.40917","journal-title":"Arthr Rheumatol"},{"key":"4498_CR52","doi-asserted-by":"publisher","DOI":"10.1002\/art.41802","author":"JS Hanberg","year":"2021","unstructured":"Hanberg JS, Hsieh E, Akg\u00fcn KM et al (2021) Incident rheumatoid arthritis in human immunodeficiency virus infection: epidemiology and treatment. Arthr Rheumatol. https:\/\/doi.org\/10.1002\/art.41802","journal-title":"Arthr Rheumatol"},{"key":"4498_CR53","doi-asserted-by":"publisher","first-page":"e339","DOI":"10.1038\/emm.2017.24","volume":"49","author":"D Kim","year":"2017","unstructured":"Kim D, Zeng MY, N\u00fa\u00f1ez G (2017) The interplay between host immune cells and gut microbiota in chronic inflammatory diseases. Exp Mol Med 49:e339\u2013e339. https:\/\/doi.org\/10.1038\/emm.2017.24","journal-title":"Exp Mol Med"},{"key":"4498_CR54","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1186\/s40168-021-01028-7","volume":"9","author":"D Li","year":"2021","unstructured":"Li D, Feng Y, Tian M et al (2021) Gut microbiota-derived inosine from dietary barley leaf supplementation attenuates colitis through PPAR\u03b3 signaling activation. Microbiome 9:83. https:\/\/doi.org\/10.1186\/s40168-021-01028-7","journal-title":"Microbiome"},{"key":"4498_CR55","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1016\/j.it.2021.05.006","volume":"42","author":"K Zubeidat","year":"2021","unstructured":"Zubeidat K, Hovav A-H (2021) Shaped by the epithelium -postnatal immune mechanisms of oral homeostasis. Trends Immunol 42:622\u2013634. https:\/\/doi.org\/10.1016\/j.it.2021.05.006","journal-title":"Trends Immunol"},{"key":"4498_CR56","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1002\/art.40490","volume":"70","author":"WK Jubair","year":"2018","unstructured":"Jubair WK, Hendrickson JD, Severs EL et al (2018) Modulation of inflammatory arthritis in mice by gut microbiota through mucosal inflammation and autoantibody generation. Arthr Rheumatol 70:1220\u20131233. https:\/\/doi.org\/10.1002\/art.40490","journal-title":"Arthr Rheumatol"},{"key":"4498_CR57","doi-asserted-by":"publisher","first-page":"2646","DOI":"10.1002\/art.39783","volume":"68","author":"Y Maeda","year":"2016","unstructured":"Maeda Y, Kurakawa T, Umemoto E et al (2016) Dysbiosis contributes to arthritis development via activation of autoreactive T cells in the intestine. Arthr Rheumatol 68:2646\u20132661. https:\/\/doi.org\/10.1002\/art.39783","journal-title":"Arthr Rheumatol"},{"key":"4498_CR58","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.chom.2019.07.008","volume":"26","author":"BT Tierney","year":"2019","unstructured":"Tierney BT, Yang Z, Luber JM et al (2019) The landscape of genetic content in the gut and oral human microbiome. Cell Host Microbe 26:283-295.e288. https:\/\/doi.org\/10.1016\/j.chom.2019.07.008","journal-title":"Cell Host Microbe"},{"key":"4498_CR59","doi-asserted-by":"publisher","first-page":"e45931","DOI":"10.7554\/eLife.45931","volume":"8","author":"A Prodan","year":"2019","unstructured":"Prodan A, Levin E, Nieuwdorp M (2019) Does disease start in the mouth, the gut or both? Elife 8:e45931. https:\/\/doi.org\/10.7554\/eLife.45931","journal-title":"Elife"},{"key":"4498_CR60","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/s41522-019-0084-7","volume":"5","author":"A El-Awady","year":"2019","unstructured":"El-Awady A, de Sousa Rabelo M, Meghil MM et al (2019) Polymicrobial synergy within oral biofilm promotes invasion of dendritic cells and survival of consortia members. npj Biofilms Microbiomes 5:11. https:\/\/doi.org\/10.1038\/s41522-019-0084-7","journal-title":"npj Biofilms Microbiomes"},{"key":"4498_CR61","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2020.102581","volume":"117","author":"Y Okamato","year":"2021","unstructured":"Okamato Y, Ghosh T, Okamoto T et al (2021) Subjects at-risk for future development of rheumatoid arthritis demonstrate a PAD4-and TLR-dependent enhanced histone H3 citrullination and proinflammatory cytokine production in CD14hi monocytes. J Autoimmun 117:102581. https:\/\/doi.org\/10.1016\/j.jaut.2020.102581","journal-title":"J Autoimmun"},{"key":"4498_CR62","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1021\/acs.accounts.9b00024","volume":"52","author":"S Mondal","year":"2019","unstructured":"Mondal S, Thompson PR (2019) Protein arginine deiminases (PADs): biochemistry and chemical biology of protein citrullination. Acc Chem Res 52:818\u2013832. https:\/\/doi.org\/10.1021\/acs.accounts.9b00024","journal-title":"Acc Chem Res"},{"key":"4498_CR63","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1038\/s41584-020-0409-1","volume":"16","author":"AM Curran","year":"2020","unstructured":"Curran AM, Naik P, Giles JT et al (2020) PAD enzymes in rheumatoid arthritis: pathogenic effectors and autoimmune targets. Nat Rev Rheumatol 16:301\u2013315. https:\/\/doi.org\/10.1038\/s41584-020-0409-1","journal-title":"Nat Rev Rheumatol"},{"key":"4498_CR64","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1136\/annrheumdis-2015-207656","volume":"75","author":"AB Montgomery","year":"2016","unstructured":"Montgomery AB, Kopec J, Shrestha L et al (2016) Crystal structure of Porphyromonas gingivalis peptidylarginine deiminase: implications for autoimmunity in rheumatoid arthritis. Ann Rheum Dis 75:1255. https:\/\/doi.org\/10.1136\/annrheumdis-2015-207656","journal-title":"Ann Rheum Dis"},{"key":"4498_CR65","volume-title":"Porphyromonas gingivalis, the beast with two heads. A bacterial role in the etiology of rheumatoid arthritis","author":"G Gabarrini","year":"2018","unstructured":"Gabarrini G (2018) Porphyromonas gingivalis, the beast with two heads. A bacterial role in the etiology of rheumatoid arthritis. University of Groningen, Groningen"},{"key":"4498_CR66","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2021.166836","volume":"433","author":"I Lunar Silva","year":"2021","unstructured":"Lunar Silva I, Cascales E (2021) Molecular strategies underlying Porphyromonas gingivalis virulence. J Mol Biol 433:166836. https:\/\/doi.org\/10.1016\/j.jmb.2021.166836","journal-title":"J Mol Biol"},{"key":"4498_CR67","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008124","volume":"15","author":"H Takeuchi","year":"2019","unstructured":"Takeuchi H, Sasaki N, Yamaga S et al (2019) Porphyromonas gingivalis induces penetration of lipopolysaccharide and peptidoglycan through the gingival epithelium via degradation of junctional adhesion molecule 1. PLoS Pathog 15:e1008124. https:\/\/doi.org\/10.1371\/journal.ppat.1008124","journal-title":"PLoS Pathog"},{"key":"4498_CR68","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1136\/annrheumdis-2012-202726","volume":"73","author":"A-M Quirke","year":"2014","unstructured":"Quirke A-M, Lugli EB, Wegner N et al (2014) Heightened immune response to autocitrullinated Porphyromonas gingivalis peptidylarginine deiminase: a potential mechanism for breaching immunologic tolerance in rheumatoid arthritis. Ann Rheum Dis 73:263. https:\/\/doi.org\/10.1136\/annrheumdis-2012-202726","journal-title":"Ann Rheum Dis"},{"key":"4498_CR69","doi-asserted-by":"publisher","first-page":"e00032-00019","DOI":"10.1128\/MMBR.00032-19","volume":"84","author":"G Gabarrini","year":"2020","unstructured":"Gabarrini G, Grasso S, van Winkelhoff Arie J et al (2020) Gingimaps: protein localization in the oral pathogen Porphyromonas gingivalis. Microbiol Mol Biol Rev 84:e00032-00019. https:\/\/doi.org\/10.1128\/MMBR.00032-19","journal-title":"Microbiol Mol Biol Rev"},{"key":"4498_CR70","doi-asserted-by":"publisher","first-page":"140","DOI":"10.3389\/fcimb.2017.00140","volume":"7","author":"I Glowczyk","year":"2017","unstructured":"Glowczyk I, Wong A, Potempa B et al (2017) Inactive gingipains from P. gingivalis selectively skews T cells toward a Th17 phenotype in an IL-6 dependent manner. Front Cell Infect Microbiol 7:140","journal-title":"Front Cell Infect Microbiol"},{"key":"4498_CR71","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1016\/j.chom.2014.05.012","volume":"15","author":"T Maekawa","year":"2014","unstructured":"Maekawa T, Krauss JL, Abe T et al (2014) Porphyromonas gingivalis manipulates complement and TLR Signaling To Uncouple Bacterial Clearance From Inflammation And Promote Dysbiosis. Cell Host Microbe 15:768\u2013778. https:\/\/doi.org\/10.1016\/j.chom.2014.05.012","journal-title":"Cell Host Microbe"},{"key":"4498_CR72","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1002\/JPER.20-0295","volume":"92","author":"D Manoil","year":"2021","unstructured":"Manoil D, Bostanci N, Mumcu G et al (2021) Novel and known periodontal pathogens residing in gingival crevicular fluid are associated with rheumatoid arthritis. J Periodontol 92:359\u2013370. https:\/\/doi.org\/10.1002\/JPER.20-0295","journal-title":"J Periodontol"},{"key":"4498_CR73","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1111\/jcpe.12102","volume":"40","author":"S Reichert","year":"2013","unstructured":"Reichert S, Haffner M, Key\u00dfer G et al (2013) Detection of oral bacterial DNA in synovial fluid. J Clin Periodontol 40:591\u2013598. https:\/\/doi.org\/10.1111\/jcpe.12102","journal-title":"J Clin Periodontol"},{"key":"4498_CR74","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1515\/hsz-2019-0387","volume":"401","author":"MT Sarwar","year":"2020","unstructured":"Sarwar MT, Ohara-Nemoto Y, Kobayakawa T et al (2020) Characterization of substrate specificity and novel autoprocessing mechanism of dipeptidase A from Prevotella intermedia. Biol Chem 401:629\u2013642. https:\/\/doi.org\/10.1515\/hsz-2019-0387","journal-title":"Biol Chem"},{"key":"4498_CR75","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-021-00559-y","author":"A Tett","year":"2021","unstructured":"Tett A, Pasolli E, Masetti G et al (2021) Prevotella diversity, niches and interactions with the human host. Nat Rev Microbiol. https:\/\/doi.org\/10.1038\/s41579-021-00559-y","journal-title":"Nat Rev Microbiol"},{"key":"4498_CR76","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/j.chom.2019.10.020","volume":"26","author":"SP Claus","year":"2019","unstructured":"Claus SP (2019) The strange case of Prevotella copri: Dr. Jekyll or Mr. Hyde? Cell Host Microbe 26:577\u2013578. https:\/\/doi.org\/10.1016\/j.chom.2019.10.020","journal-title":"Cell Host Microbe"},{"key":"4498_CR77","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/j.cmet.2015.10.001","volume":"22","author":"P Kovatcheva-Datchary","year":"2015","unstructured":"Kovatcheva-Datchary P, Nilsson A, Akrami R et al (2015) Dietary fiber-induced improvement in glucose metabolism is associated with increased abundance of Prevotella. Cell Metab 22:971\u2013982. https:\/\/doi.org\/10.1016\/j.cmet.2015.10.001","journal-title":"Cell Metab"},{"key":"4498_CR78","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1136\/annrheumdis-2019-215743","volume":"79","author":"T Kishikawa","year":"2020","unstructured":"Kishikawa T, Maeda Y, Nii T et al (2020) Metagenome-wide association study of gut microbiome revealed novel aetiology of rheumatoid arthritis in the Japanese population. Ann Rheum Dis 79:103. https:\/\/doi.org\/10.1136\/annrheumdis-2019-215743","journal-title":"Ann Rheum Dis"},{"key":"4498_CR79","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s12276-019-0283-6","volume":"51","author":"Y Maeda","year":"2019","unstructured":"Maeda Y, Takeda K (2019) Host\u2013microbiota interactions in rheumatoid arthritis. Exp Mol Med 51:1\u20136. https:\/\/doi.org\/10.1038\/s12276-019-0283-6","journal-title":"Exp Mol Med"},{"key":"4498_CR80","doi-asserted-by":"publisher","first-page":"2946","DOI":"10.1172\/JCI93450","volume":"127","author":"A Pianta","year":"2017","unstructured":"Pianta A, Arvikar SL, Strle K et al (2017) Two rheumatoid arthritis\u2013specific autoantigens correlate microbial immunity with autoimmune responses in joints. J Clin Investig 127:2946\u20132956. https:\/\/doi.org\/10.1172\/JCI93450","journal-title":"J Clin Investig"},{"key":"4498_CR81","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1136\/annrheumdis-2018-212942","volume":"77","author":"DS Pisetsky","year":"2018","unstructured":"Pisetsky DS (2018) How the gut inflames the joints. Ann Rheum Dis 77:634. https:\/\/doi.org\/10.1136\/annrheumdis-2018-212942","journal-title":"Ann Rheum Dis"},{"key":"4498_CR82","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j839","volume":"356","author":"K McAllister","year":"2017","unstructured":"McAllister K, Goodson N, Warburton L et al (2017) Spondyloarthritis: diagnosis and management: summary of NICE guidance. BMJ 356:j839. https:\/\/doi.org\/10.1136\/bmj.j839","journal-title":"BMJ"},{"key":"4498_CR83","doi-asserted-by":"publisher","first-page":"2933","DOI":"10.3389\/fimmu.2018.02933","volume":"9","author":"F Costantino","year":"2018","unstructured":"Costantino F, Breban M, Garchon H-J (2018) Genetics and functional genomics of spondyloarthritis. Front Immunol 9:2933","journal-title":"Front Immunol"},{"key":"4498_CR84","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1111\/j.1399-0039.2004.00158.x","volume":"63","author":"E Zino","year":"2004","unstructured":"Zino E, Terlizzi SD, Carugo C et al (2004) Rapid detection of all HLA-B*27 alleles (B*2701\u2013B*2725) by group-specific polymerase chain reaction. Tissue Antigens 63:88\u201392. https:\/\/doi.org\/10.1111\/j.1399-0039.2004.00158.x","journal-title":"Tissue Antigens"},{"key":"4498_CR85","doi-asserted-by":"publisher","first-page":"3004","DOI":"10.1093\/rheumatology\/keaa746","volume":"60","author":"JR Parida","year":"2021","unstructured":"Parida JR, Kumar S, Ahmed S et al (2021) Reactive arthritis and undifferentiated peripheral spondyloarthritis share human leucocyte antigen B27 subtypes and serum and synovial fluid cytokine profiles. Rheumatology 60:3004\u20133011. https:\/\/doi.org\/10.1093\/rheumatology\/keaa746","journal-title":"Rheumatology"},{"key":"4498_CR86","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1002\/art.40405","volume":"70","author":"T Gill","year":"2018","unstructured":"Gill T, Asquith M, Brooks SR et al (2018) Effects of HLA\u2013B27 on gut microbiota in experimental spondyloarthritis implicate an ecological model of dysbiosis. Arthr Rheumatol 70:555\u2013565. https:\/\/doi.org\/10.1002\/art.40405","journal-title":"Arthr Rheumatol"},{"key":"4498_CR87","doi-asserted-by":"publisher","first-page":"vi4","DOI":"10.1093\/rheumatology\/key001","volume":"57","author":"D Simone","year":"2018","unstructured":"Simone D, Al-Mossawi MH, Bowness P (2018) Progress in our understanding of the pathogenesis of ankylosing spondylitis. Rheumatology 57:vi4\u2013vi9. https:\/\/doi.org\/10.1093\/rheumatology\/key001","journal-title":"Rheumatology"},{"key":"4498_CR88","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1084\/jem.182.4.1153","volume":"182","author":"SD Khare","year":"1995","unstructured":"Khare SD, Luthra HS, David CS (1995) Spontaneous inflammatory arthritis in HLA-B27 transgenic mice lacking beta 2-microglobulin: a model of human spondyloarthropathies. J Exp Med 182:1153\u20131158. https:\/\/doi.org\/10.1084\/jem.182.4.1153","journal-title":"J Exp Med"},{"key":"4498_CR89","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1016\/0092-8674(90)90512-D","volume":"63","author":"RE Hammer","year":"1990","unstructured":"Hammer RE, Maika SD, Richardson JA et al (1990) Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human \u03b22m: an animal model of HLA-B27-associated human disorders. Cell 63:1099\u20131112. https:\/\/doi.org\/10.1016\/0092-8674(90)90512-D","journal-title":"Cell"},{"key":"4498_CR90","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1136\/annrheumdis-2019-215349","volume":"78","author":"Z Qaiyum","year":"2019","unstructured":"Qaiyum Z, Gracey E, Yao Y et al (2019) Integrin and transcriptomic profiles identify a distinctive synovial CD8+ T cell subpopulation in spondyloarthritis. Ann Rheum Dis 78:1566. https:\/\/doi.org\/10.1136\/annrheumdis-2019-215349","journal-title":"Ann Rheum Dis"},{"key":"4498_CR91","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-216456","author":"G Guggino","year":"2019","unstructured":"Guggino G, Rizzo A, Mauro D et al (2019) Gut-derived CD8+ tissue-resident memory T cells are expanded in the peripheral blood and synovia of SpA patients. Ann Rheum Dis. https:\/\/doi.org\/10.1136\/annrheumdis-2019-216456","journal-title":"Ann Rheum Dis"},{"key":"4498_CR92","doi-asserted-by":"publisher","first-page":"3510","DOI":"10.3389\/fimmu.2020.586494","volume":"11","author":"T Gill","year":"2021","unstructured":"Gill T, Rosenbaum JT (2021) Putative pathobionts in HLA-B27-associated spondyloarthropathy. Front Immunol 11:3510","journal-title":"Front Immunol"},{"key":"4498_CR93","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.pharmthera.2019.03.006","volume":"199","author":"K Uchiyama","year":"2019","unstructured":"Uchiyama K, Naito Y, Takagi T (2019) Intestinal microbiome as a novel therapeutic target for local and systemic inflammation. Pharmacol Ther 199:164\u2013172","journal-title":"Pharmacol Ther"},{"key":"4498_CR94","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1111\/imm.13242","volume":"161","author":"A Voruganti","year":"2020","unstructured":"Voruganti A, Bowness P (2020) New developments in our understanding of ankylosing spondylitis pathogenesis. Immunology 161:94\u2013102. https:\/\/doi.org\/10.1111\/imm.13242","journal-title":"Immunology"},{"key":"4498_CR95","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1016\/S0140-6736(07)60635-7","volume":"369","author":"J Braun","year":"2007","unstructured":"Braun J, Sieper J (2007) Ankylosing spondylitis. Lancet 369:1379\u20131390. https:\/\/doi.org\/10.1016\/S0140-6736(07)60635-7","journal-title":"Lancet"},{"key":"4498_CR96","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/242121a0","volume":"242","author":"MFP Caffrey","year":"1973","unstructured":"Caffrey MFP, James DCO (1973) Human lymphocyte antigen association in ankylosing spondylitis. Nature 242:121\u2013121","journal-title":"Nature"},{"key":"4498_CR97","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202100549","author":"Z Peng","year":"2021","unstructured":"Peng Z, Wu J, Wang K et al (2021) Production of a promising biosynthetic self-assembled nanoconjugate vaccine against klebsiella pneumoniae serotype O2 in a general Escherichia coli host. Adv Sci. https:\/\/doi.org\/10.1002\/advs.202100549","journal-title":"Adv Sci"},{"key":"4498_CR98","first-page":"27","volume":"58","author":"A Ebringer","year":"1976","unstructured":"Ebringer A, Cowling P, Ngwa-Suh N et al (1976) Cross-reactivity between Klebsiella aerogenes species and B27 lymphocyte antigens as an aetiological factor in ankylosing spondylitis. HLA Dis Paris INSERM 58:27","journal-title":"HLA Dis Paris INSERM"},{"key":"4498_CR99","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/277068a0","volume":"277","author":"K Seager","year":"1979","unstructured":"Seager K, Bashir HV, Geczy AF et al (1979) Evidence for a specific B27-associated cell surface marker on lymphocytes of patients with ankylosing spondylitis. Nature 277:68\u201370. https:\/\/doi.org\/10.1038\/277068a0","journal-title":"Nature"},{"key":"4498_CR100","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1007\/s10067-006-0488-7","volume":"26","author":"T Rashid","year":"2007","unstructured":"Rashid T, Ebringer A (2007) Ankylosing spondylitis is linked to Klebsiella\u2014the evidence. Clin Rheumatol 26:858\u2013864. https:\/\/doi.org\/10.1007\/s10067-006-0488-7","journal-title":"Clin Rheumatol"},{"key":"4498_CR101","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1093\/rheumatology\/keg482","volume":"43","author":"MA Stone","year":"2004","unstructured":"Stone MA, Payne U, Schentag C et al (2004) Comparative immune responses to candidate arthritogenic bacteria do not confirm a dominant role for Klebsiella pneumonia in the pathogenesis of familial ankylosing spondylitis. Rheumatology 43:148\u2013155. https:\/\/doi.org\/10.1093\/rheumatology\/keg482","journal-title":"Rheumatology"},{"key":"4498_CR102","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8884324","author":"G Liu","year":"2020","unstructured":"Liu G, Hao Y, Yang Q et al (2020) The association of fecal microbiota in ankylosing spondylitis cases with C-reactive protein and erythrocyte sedimentation rate. Mediat Inflamm. https:\/\/doi.org\/10.1155\/2020\/8884324","journal-title":"Mediat Inflamm"},{"key":"4498_CR103","doi-asserted-by":"publisher","first-page":"102360","DOI":"10.1016\/j.jaut.2019.102360","volume":"107","author":"C Zhou","year":"2020","unstructured":"Zhou C, Zhao H, Xiao X-Y et al (2020) Metagenomic profiling of the pro-inflammatory gut microbiota in ankylosing spondylitis. J Autoimmun 107:102360","journal-title":"J Autoimmun"},{"key":"4498_CR104","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1038\/s41584-021-00578-2","volume":"17","author":"LM Perez-Chada","year":"2021","unstructured":"Perez-Chada LM, Haberman RH, Chandran V et al (2021) Consensus terminology for preclinical phases of psoriatic arthritis for use in research studies: results from a Delphi consensus study. Nat Rev Rheumatol 17:238\u2013243. https:\/\/doi.org\/10.1038\/s41584-021-00578-2","journal-title":"Nat Rev Rheumatol"},{"key":"4498_CR105","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.jaad.2015.05.001","volume":"73","author":"AP Villani","year":"2015","unstructured":"Villani AP, Rouzaud M, Sevrain M et al (2015) Prevalence of undiagnosed psoriatic arthritis among psoriasis patients: systematic review and meta-analysis. J Am Acad Dermatol 73:242\u2013248. https:\/\/doi.org\/10.1016\/j.jaad.2015.05.001","journal-title":"J Am Acad Dermatol"},{"key":"4498_CR106","doi-asserted-by":"publisher","first-page":"2431","DOI":"10.3389\/fimmu.2020.571319","volume":"11","author":"S Yegorov","year":"2020","unstructured":"Yegorov S, Babenko D, Kozhakhmetov S et al (2020) Psoriasis is associated with elevated gut IL-1\u03b1 and intestinal microbiome alterations. Front Immunol 11:2431","journal-title":"Front Immunol"},{"key":"4498_CR107","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1002\/art.38892","volume":"67","author":"JU Scher","year":"2015","unstructured":"Scher JU, Ubeda C, Artacho A et al (2015) Decreased bacterial diversity characterizes the altered gut microbiota in patients with psoriatic arthritis, resembling dysbiosis in inflammatory bowel disease. Arthritis Rheumatol 67:128\u2013139. https:\/\/doi.org\/10.1002\/art.38892","journal-title":"Arthritis Rheumatol"},{"key":"4498_CR108","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40168-020-00939-1","volume":"9","author":"JW Arnold","year":"2021","unstructured":"Arnold JW, Roach J, Fabela S et al (2021) The pleiotropic effects of prebiotic galacto-oligosaccharides on the aging gut. Microbiome 9:1\u20139","journal-title":"Microbiome"},{"key":"4498_CR109","doi-asserted-by":"publisher","first-page":"109131","DOI":"10.1016\/j.biopha.2019.109131","volume":"118","author":"W Zhang","year":"2019","unstructured":"Zhang W, Xu J-H, Yu T et al (2019) Effects of berberine and metformin on intestinal inflammation and gut microbiome composition in db\/db mice. Biomed Pharmacother 118:109131","journal-title":"Biomed Pharmacother"},{"key":"4498_CR110","doi-asserted-by":"publisher","first-page":"9039","DOI":"10.1021\/acs.jafc.9b04253","volume":"67","author":"B Li","year":"2019","unstructured":"Li B, Ge Y, Xu Y et al (2019) Spatial learning and memory impairment in growing mice induced by major oxidized tyrosine product dityrosine. J Agric Food Chem 67:9039\u20139049. https:\/\/doi.org\/10.1021\/acs.jafc.9b04253","journal-title":"J Agric Food Chem"},{"key":"4498_CR111","doi-asserted-by":"publisher","first-page":"3175","DOI":"10.1038\/s41467-021-23549-3","volume":"12","author":"Q Wang","year":"2021","unstructured":"Wang Q, Hern\u00e1ndez-Ochoa EO, Viswanathan MC et al (2021) CaMKII oxidation is a critical performance\/disease trade-off acquired at the dawn of vertebrate evolution. Nat Commun 12:3175. https:\/\/doi.org\/10.1038\/s41467-021-23549-3","journal-title":"Nat Commun"},{"key":"4498_CR112","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.stem.2021.02.011","volume":"28","author":"RP Chakrabarty","year":"2021","unstructured":"Chakrabarty RP, Chandel NS (2021) Mitochondria as signaling organelles control mammalian stem cell fate. Cell Stem Cell 28:394\u2013408. https:\/\/doi.org\/10.1016\/j.stem.2021.02.011","journal-title":"Cell Stem Cell"},{"key":"4498_CR113","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1172\/JCI79735","volume":"125","author":"W Xiong","year":"2015","unstructured":"Xiong W, MacColl Garfinkel AE, Li Y et al (2015) NRF2 promotes neuronal survival in neurodegeneration and acute nerve damage. J Clin Investig 125:1433\u20131445. https:\/\/doi.org\/10.1172\/JCI79735","journal-title":"J Clin Investig"},{"key":"4498_CR114","doi-asserted-by":"publisher","first-page":"2116","DOI":"10.3389\/fimmu.2021.698042","volume":"12","author":"A Dumas","year":"2021","unstructured":"Dumas A, Knaus UG (2021) Raising the \u2018good\u2019 oxidants for immune protection. Front Immunol 12:2116","journal-title":"Front Immunol"},{"key":"4498_CR115","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1007\/s40820-020-0410-x","volume":"12","author":"X-X Fan","year":"2020","unstructured":"Fan X-X, Xu M-Z, Leung EL-H et al (2020) ROS-responsive berberine polymeric micelles effectively suppressed the inflammation of rheumatoid arthritis by targeting mitochondria. Nano-Micro Letters 12:76. https:\/\/doi.org\/10.1007\/s40820-020-0410-x","journal-title":"Nano-Micro Letters"},{"key":"4498_CR116","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22020723","author":"P W\u00f3jcik","year":"2021","unstructured":"W\u00f3jcik P, G\u0119gotek A, \u017darkovi\u0107 N et al (2021) Oxidative stress and lipid mediators modulate immune cell functions in autoimmune diseases. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms22020723","journal-title":"Int J Mol Sci"},{"key":"4498_CR117","doi-asserted-by":"publisher","first-page":"2835","DOI":"10.1042\/CS20190728","volume":"134","author":"MM Steinz","year":"2020","unstructured":"Steinz MM, Santos-Alves E, Lanner JT (2020) Skeletal muscle redox signaling in rheumatoid arthritis. Clin Sci 134:2835\u20132850. https:\/\/doi.org\/10.1042\/CS20190728","journal-title":"Clin Sci"},{"key":"4498_CR118","doi-asserted-by":"publisher","first-page":"eaaz5327","DOI":"10.1126\/scitranslmed.aaz5327","volume":"12","author":"H Kristyanto","year":"2020","unstructured":"Kristyanto H, Blomberg NJ, Slot LM et al (2020) Persistently activated, proliferative memory autoreactive B cells promote inflammation in rheumatoid arthritis. Sci Transl Med 12:eaaz5327. https:\/\/doi.org\/10.1126\/scitranslmed.aaz5327","journal-title":"Sci Transl Med"},{"key":"4498_CR119","doi-asserted-by":"publisher","first-page":"2033","DOI":"10.1172\/JCI27544","volume":"116","author":"PM-C Dang","year":"2006","unstructured":"Dang PM-C, Stensballe A, Boussetta T et al (2006) A specific p47phox -serine phosphorylated by convergent MAPKs mediates neutrophil NADPH oxidase priming at inflammatory sites. J Clin Investig 116:2033\u20132043. https:\/\/doi.org\/10.1172\/JCI27544","journal-title":"J Clin Investig"},{"key":"4498_CR120","doi-asserted-by":"publisher","first-page":"3364","DOI":"10.3389\/fimmu.2020.584116","volume":"11","author":"HL Wright","year":"2021","unstructured":"Wright HL, Lyon M, Chapman EA et al (2021) Rheumatoid arthritis synovial fluid neutrophils drive inflammation through production of chemokines, reactive oxygen species, and neutrophil extracellular traps. Front Immunol 11:3364","journal-title":"Front Immunol"},{"key":"4498_CR121","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.1007\/s10067-014-2597-z","volume":"33","author":"S Datta","year":"2014","unstructured":"Datta S, Kundu S, Ghosh P et al (2014) Correlation of oxidant status with oxidative tissue damage in patients with rheumatoid arthritis. Clin Rheumatol 33:1557\u20131564. https:\/\/doi.org\/10.1007\/s10067-014-2597-z","journal-title":"Clin Rheumatol"},{"key":"4498_CR122","doi-asserted-by":"publisher","first-page":"3206","DOI":"10.1021\/acsnano.8b08785","volume":"13","author":"J Kim","year":"2019","unstructured":"Kim J, Kim HY, Song SY et al (2019) Synergistic oxygen generation and reactive oxygen species scavenging by manganese ferrite\/ceria co-decorated nanoparticles for rheumatoid arthritis treatment. ACS Nano 13:3206\u20133217. https:\/\/doi.org\/10.1021\/acsnano.8b08785","journal-title":"ACS Nano"},{"key":"4498_CR123","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/j.freeradbiomed.2017.12.004","volume":"115","author":"X Su","year":"2018","unstructured":"Su X, Li T, Liu Z et al (2018) Licochalcone A activates Keap1-Nrf2 signaling to suppress arthritis via phosphorylation of p62 at serine 349. Free Radic Biol Med 115:471\u2013483. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2017.12.004","journal-title":"Free Radic Biol Med"},{"key":"4498_CR124","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1042\/BST20150014","volume":"43","author":"JD Wardyn","year":"2015","unstructured":"Wardyn JD, Ponsford AH, Sanderson CM (2015) Dissecting molecular cross-talk between Nrf2 and NF-\u03baB response pathways. Biochem Soc Trans 43:621\u2013626. https:\/\/doi.org\/10.1042\/BST20150014","journal-title":"Biochem Soc Trans"},{"key":"4498_CR125","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2020.101207","volume":"65","author":"W Zhang","year":"2021","unstructured":"Zhang W, Feng C, Jiang H (2021) Novel target for treating Alzheimer\u2019s diseases: crosstalk between the Nrf2 pathway and autophagy. Ageing Res Rev 65:101207. https:\/\/doi.org\/10.1016\/j.arr.2020.101207","journal-title":"Ageing Res Rev"},{"key":"4498_CR126","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/8564681","author":"X Gao","year":"2019","unstructured":"Gao X, Jiang S, Du Z et al (2019) In vitroKLF2 protects against osteoarthritis by repressing oxidative response through activation of Nrf2\/ARE signaling in vitro and in vivo. Oxid Med Cell Longev. https:\/\/doi.org\/10.1155\/2019\/8564681","journal-title":"Oxid Med Cell Longev"},{"key":"4498_CR127","doi-asserted-by":"publisher","DOI":"10.3390\/nu13020311","author":"ML Castej\u00f3n","year":"2021","unstructured":"Castej\u00f3n ML, Alarc\u00f3n-de-la-Lastra C, Rosillo M\u00c1 et al (2021) A new peracetylated oleuropein derivative ameliorates joint inflammation and destruction in a murine collagen-induced arthritis model via activation of the Nrf-2\/Ho-1 antioxidant pathway and suppression of MAPKs and NF-\u03baB activation. Nutrients. https:\/\/doi.org\/10.3390\/nu13020311","journal-title":"Nutrients"},{"key":"4498_CR128","first-page":"2369","volume":"11","author":"Y Luo","year":"2021","unstructured":"Luo Y, Xiong B, Liu H et al (2021) Koumine suppresses IL-1\u03b2 secretion and attenuates inflammation associated with blocking ROS\/NF-\u03baB\/NLRP3 axis in macrophages. Front Pharmacol 11:2369","journal-title":"Front Pharmacol"},{"key":"4498_CR129","doi-asserted-by":"publisher","first-page":"6042","DOI":"10.1038\/s41467-020-19939-8","volume":"11","author":"H Song","year":"2020","unstructured":"Song H, Zhao C, Yu Z et al (2020) UAF1 deubiquitinase complexes facilitate NLRP3 inflammasome activation by promoting NLRP3 expression. Nat Commun 11:6042. https:\/\/doi.org\/10.1038\/s41467-020-19939-8","journal-title":"Nat Commun"},{"key":"4498_CR130","doi-asserted-by":"publisher","first-page":"13046","DOI":"10.1111\/jcmm.15905","volume":"24","author":"Z Yan","year":"2020","unstructured":"Yan Z, Qi W, Zhan J et al (2020) Activating Nrf2 signalling alleviates osteoarthritis development by inhibiting inflammasome activation. J Cell Mol Med 24:13046\u201313057. https:\/\/doi.org\/10.1111\/jcmm.15905","journal-title":"J Cell Mol Med"},{"key":"4498_CR131","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101544","volume":"33","author":"PJ Barnes","year":"2020","unstructured":"Barnes PJ (2020) Oxidative stress-based therapeutics in COPD. Redox Biol 33:101544. https:\/\/doi.org\/10.1016\/j.redox.2020.101544","journal-title":"Redox Biol"},{"key":"4498_CR132","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1136\/ard.2007.077040","volume":"67","author":"S Garc\u00eda","year":"2008","unstructured":"Garc\u00eda S, Boda\u00f1o A, Pablos JL et al (2008) Poly(ADP-ribose) polymerase inhibition reduces tumor necrosis factor-induced inflammatory response in rheumatoid synovial fibroblasts. Ann Rheum Dis 67:631. https:\/\/doi.org\/10.1136\/ard.2007.077040","journal-title":"Ann Rheum Dis"},{"key":"4498_CR133","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.retram.2020.05.002","volume":"68","author":"S Chadha","year":"2020","unstructured":"Chadha S, Behl T, Kumar A et al (2020) Role of Nrf2 in rheumatoid arthritis. Curr Res Transl Med 68:171\u2013181. https:\/\/doi.org\/10.1016\/j.retram.2020.05.002","journal-title":"Curr Res Transl Med"},{"key":"4498_CR134","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1002\/mc.20225","volume":"45","author":"H-K Na","year":"2006","unstructured":"Na H-K, Surh Y-J (2006) Transcriptional regulation via cysteine thiol modification: a novel molecular strategy for chemoprevention and cytoprotection. Mol Carcinog 45:368\u2013380. https:\/\/doi.org\/10.1002\/mc.20225","journal-title":"Mol Carcinog"},{"key":"4498_CR135","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22084002","author":"K-T Tang","year":"2021","unstructured":"Tang K-T, Lin C-C, Lin S-C et al (2021) Kurarinone attenuates collagen-induced arthritis in mice by inhibiting Th1\/Th17 cell responses and oxidative stress. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms22084002","journal-title":"Int J Mol Sci"},{"key":"4498_CR136","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10020323","author":"M S\u00e1nchez Macarro","year":"2021","unstructured":"S\u00e1nchez Macarro M, \u00c1vila-Gand\u00eda V, P\u00e9rez-Pi\u00f1ero S et al (2021) Antioxidant effect of a probiotic product on a model of oxidative stress induced by high-intensity and duration physical exercise. Antioxidants. https:\/\/doi.org\/10.3390\/antiox10020323","journal-title":"Antioxidants"},{"key":"4498_CR137","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.1007\/s00253-021-11111-6","volume":"105","author":"L Hao","year":"2021","unstructured":"Hao L, Cheng Y, Su W et al (2021) Pediococcus pentosaceus ZJUAF-4 relieves oxidative stress and restores the gut microbiota in diquat-induced intestinal injury. Appl Microbiol Biotechnol 105:1657\u20131668. https:\/\/doi.org\/10.1007\/s00253-021-11111-6","journal-title":"Appl Microbiol Biotechnol"},{"key":"4498_CR138","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1038\/s41598-020-80482-z","volume":"11","author":"MJM Monteros","year":"2021","unstructured":"Monteros MJM, Galdeano CM, Balcells MF et al (2021) Probiotic lactobacilli as a promising strategy to ameliorate disorders associated with intestinal inflammation induced by a non-steroidal anti-inflammatory drug. Sci Rep 11:571. https:\/\/doi.org\/10.1038\/s41598-020-80482-z","journal-title":"Sci Rep"},{"key":"4498_CR139","doi-asserted-by":"publisher","DOI":"10.1038\/cti.2016.29","volume":"5","author":"JL Richards","year":"2016","unstructured":"Richards JL, Yap YA, McLeod KH et al (2016) Dietary metabolites and the gut microbiota: an alternative approach to control inflammatory and autoimmune diseases. Clin Transl Immunol 5:e82. https:\/\/doi.org\/10.1038\/cti.2016.29","journal-title":"Clin Transl Immunol"},{"key":"4498_CR140","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1152\/physrev.2001.81.3.1031","volume":"81","author":"DL Topping","year":"2001","unstructured":"Topping DL, Clifton PM (2001) Short-chain fatty acids and human colonic function: roles of resistant starch and nonstarch polysaccharides. Physiol Rev 81:1031\u20131064. https:\/\/doi.org\/10.1152\/physrev.2001.81.3.1031","journal-title":"Physiol Rev"},{"key":"4498_CR141","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.107047","volume":"89","author":"S Qiao","year":"2020","unstructured":"Qiao S, Lian X, Yue M et al (2020) Regulation of gut microbiota substantially contributes to the induction of intestinal Treg cells and consequent anti-arthritis effect of madecassoside. Int Immunopharmacol 89:107047. https:\/\/doi.org\/10.1016\/j.intimp.2020.107047","journal-title":"Int Immunopharmacol"},{"key":"4498_CR142","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.1016\/j.jid.2021.01.005","volume":"141","author":"H Mehta","year":"2021","unstructured":"Mehta H, Mashiko S, Angsana J et al (2021) Differential changes in inflammatory mononuclear phagocyte and T-cell profiles within psoriatic skin during treatment with Guselkumab vs Secukinumab. J Investig Dermatol 141:1707-1718.e1709. https:\/\/doi.org\/10.1016\/j.jid.2021.01.005","journal-title":"J Investig Dermatol"},{"key":"4498_CR143","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.108849","volume":"114","author":"B Shen","year":"2019","unstructured":"Shen B, Hu J, Song H et al (2019) Antibiotics exacerbated colitis by affecting the microbiota, Treg cells and SCFAs in IL10-deficient mice. Biomed Pharmacother 114:108849. https:\/\/doi.org\/10.1016\/j.biopha.2019.108849","journal-title":"Biomed Pharmacother"},{"key":"4498_CR144","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2020.102564","volume":"116","author":"Y Bai","year":"2021","unstructured":"Bai Y, Li Y, Marion T et al (2021) Resistant starch intake alleviates collagen-induced arthritis in mice by modulating gut microbiota and promoting concomitant propionate production. J Autoimmun 116:102564. https:\/\/doi.org\/10.1016\/j.jaut.2020.102564","journal-title":"J Autoimmun"},{"key":"4498_CR145","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1080\/08923973.2018.1480631","volume":"40","author":"T Cao","year":"2018","unstructured":"Cao T, Zhang X, Chen D et al (2018) The epigenetic modification during the induction of Foxp3 with sodium butyrate. Immunopharmacol Immunotoxicol 40:309\u2013318. https:\/\/doi.org\/10.1080\/08923973.2018.1480631","journal-title":"Immunopharmacol Immunotoxicol"},{"key":"4498_CR146","doi-asserted-by":"publisher","first-page":"4499","DOI":"10.1039\/D0FO00077A","volume":"11","author":"Z Fan","year":"2020","unstructured":"Fan Z, Yang B, Ross RP et al (2020) Protective effects of Bifidobacterium adolescentis on collagen-induced arthritis in rats depend on timing of administration. Food Funct 11:4499\u20134511. https:\/\/doi.org\/10.1039\/D0FO00077A","journal-title":"Food Funct"},{"key":"4498_CR147","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.intimp.2019.01.018","volume":"68","author":"W Hui","year":"2019","unstructured":"Hui W, Yu D, Cao Z et al (2019) Butyrate inhibit collagen-induced arthritis via Treg\/IL-10\/Th17 axis. Int Immunopharmacol 68:226\u2013233. https:\/\/doi.org\/10.1016\/j.intimp.2019.01.018","journal-title":"Int Immunopharmacol"},{"key":"4498_CR148","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1016\/j.immuni.2016.03.016","volume":"44","author":"ML Balmer","year":"2016","unstructured":"Balmer ML, Ma EH, Bantug GR et al (2016) Memory CD8+ T cells require increased concentrations of acetate induced by stress for optimal function. Immunity 44:1312\u20131324. https:\/\/doi.org\/10.1016\/j.immuni.2016.03.016","journal-title":"Immunity"},{"key":"4498_CR149","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1038\/mi.2014.44","volume":"8","author":"J Park","year":"2015","unstructured":"Park J, Kim M, Kang SG et al (2015) Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR\u2013S6K pathway. Mucosal Immunol 8:80\u201393. https:\/\/doi.org\/10.1038\/mi.2014.44","journal-title":"Mucosal Immunol"},{"key":"4498_CR150","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s41522-020-0119-0","volume":"6","author":"E Hernandez-Sanabria","year":"2020","unstructured":"Hernandez-Sanabria E, Heiremans E, Calatayud Arroyo M et al (2020) Short-term supplementation of celecoxib-shifted butyrate production on a simulated model of the gut microbial ecosystem and ameliorated in vitro inflammation. npj Biofilms Microbiomes 6:9. https:\/\/doi.org\/10.1038\/s41522-020-0119-0","journal-title":"npj Biofilms Microbiomes"},{"key":"4498_CR151","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1038\/s41586-019-1095-5","volume":"568","author":"KHG Verschueren","year":"2019","unstructured":"Verschueren KHG, Blanchet C, Felix J et al (2019) Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle. Nature 568:571\u2013575. https:\/\/doi.org\/10.1038\/s41586-019-1095-5","journal-title":"Nature"},{"key":"4498_CR152","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1016\/j.immuni.2019.11.009","volume":"51","author":"MA Lauterbach","year":"2019","unstructured":"Lauterbach MA, Hanke JE, Serefidou M et al (2019) Toll-like receptor signaling rewires macrophage metabolism and promotes histone acetylation via ATP-citrate lyase. Immunity 51:997-1011.e1017. https:\/\/doi.org\/10.1016\/j.immuni.2019.11.009","journal-title":"Immunity"},{"key":"4498_CR153","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1002\/eji.201848009","volume":"49","author":"M Luu","year":"2019","unstructured":"Luu M, Visekruna A (2019) Short-chain fatty acids: bacterial messengers modulating the immunometabolism of T cells. Eur J Immunol 49:842\u2013848. https:\/\/doi.org\/10.1002\/eji.201848009","journal-title":"Eur J Immunol"},{"key":"4498_CR154","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1038\/s41423-021-00647-2","volume":"18","author":"C Wiechers","year":"2021","unstructured":"Wiechers C, Zou M, Galvez E et al (2021) The microbiota is dispensable for the early stages of peripheral regulatory T cell induction within mesenteric lymph nodes. Cell Mol Immunol 18:1211\u20131221. https:\/\/doi.org\/10.1038\/s41423-021-00647-2","journal-title":"Cell Mol Immunol"},{"key":"4498_CR155","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2021.107928","author":"P Atanes","year":"2021","unstructured":"Atanes P, Ashik T, Persaud SJ (2021) Obesity-induced changes in human islet G protein-coupled receptor expression: Implications for metabolic regulation. Pharmacol Ther. https:\/\/doi.org\/10.1016\/j.pharmthera.2021.107928","journal-title":"Pharmacol Ther"},{"key":"4498_CR156","doi-asserted-by":"publisher","first-page":"11312","DOI":"10.1074\/jbc.M211609200","volume":"278","author":"AJ Brown","year":"2003","unstructured":"Brown AJ, Goldsworthy SM, Barnes AA et al (2003) The orphan G Protein-Coupled Receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids *. J Biol Chem 278:11312\u201311319. https:\/\/doi.org\/10.1074\/jbc.M211609200","journal-title":"J Biol Chem"},{"key":"4498_CR157","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s12974-014-0230-3","volume":"12","author":"S-P Fu","year":"2015","unstructured":"Fu S-P, Wang J-F, Xue W-J et al (2015) Anti-inflammatory effects of BHBA in both in vivo and in vitro Parkinson\u2019s disease models are mediated by GPR109A-dependent mechanisms. J Neuroinflamm 12:9. https:\/\/doi.org\/10.1186\/s12974-014-0230-3","journal-title":"J Neuroinflamm"},{"key":"4498_CR158","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1053\/j.gastro.2013.04.056","volume":"145","author":"MH Kim","year":"2013","unstructured":"Kim MH, Kang SG, Park JH et al (2013) Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice. Gastroenterology 145:396\u2013406","journal-title":"Gastroenterology"},{"key":"4498_CR159","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1126\/science.1241165","volume":"341","author":"PM Smith","year":"2013","unstructured":"Smith PM, Howitt MR, Panikov N et al (2013) The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science 341:569\u2013573","journal-title":"Science"},{"key":"4498_CR160","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1038\/nature08530","volume":"461","author":"KM Maslowski","year":"2009","unstructured":"Maslowski KM, Vieira AT, Ng A et al (2009) Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature 461:1282\u20131286. https:\/\/doi.org\/10.1038\/nature08530","journal-title":"Nature"},{"key":"4498_CR161","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.125191","author":"MB Flak","year":"2019","unstructured":"Flak MB, Colas RA, Mu\u00f1oz-Atienza E et al (2019) Inflammatory arthritis disrupts gut resolution mechanisms, promoting barrier breakdown by Porphyromonas gingivalis. JCI Insight. https:\/\/doi.org\/10.1172\/jci.insight.125191","journal-title":"JCI Insight"},{"key":"4498_CR162","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2020.105663","volume":"200","author":"HMA Fakhoury","year":"2020","unstructured":"Fakhoury HMA, Kvietys PR, AlKattan W et al (2020) Vitamin D and intestinal homeostasis: Barrier, microbiota, and immune modulation. J Steroid Biochem Mol Biol 200:105663. https:\/\/doi.org\/10.1016\/j.jsbmb.2020.105663","journal-title":"J Steroid Biochem Mol Biol"},{"key":"4498_CR163","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1002\/eji.202048876","volume":"51","author":"C Brandl","year":"2021","unstructured":"Brandl C, Bucci L, Schett G et al (2021) Crossing the barriers: revisiting the gut feeling in rheumatoid arthritis. Eur J Immunol 51:798\u2013810. https:\/\/doi.org\/10.1002\/eji.202048876","journal-title":"Eur J Immunol"},{"key":"4498_CR164","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1007\/s11926-019-0856-3","volume":"21","author":"SJ Pedersen","year":"2019","unstructured":"Pedersen SJ, Maksymowych WP (2019) The pathogenesis of ankylosing spondylitis: an update. Curr Rheumatol Rep 21:58. https:\/\/doi.org\/10.1007\/s11926-019-0856-3","journal-title":"Curr Rheumatol Rep"},{"key":"4498_CR165","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.jaci.2009.05.038","volume":"124","author":"KR Groschwitz","year":"2009","unstructured":"Groschwitz KR, Hogan SP (2009) Intestinal barrier function: molecular regulation and disease pathogenesis. J Allergy Clin Immunol 124:3\u201322. https:\/\/doi.org\/10.1016\/j.jaci.2009.05.038","journal-title":"J Allergy Clin Immunol"},{"key":"4498_CR166","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/j.bbamem.2007.10.018","volume":"1778","author":"G Krause","year":"2008","unstructured":"Krause G, Winkler L, Mueller SL et al (2008) Structure and function of claudins. Biochim Biophys Acta (BBA) 1778:631\u2013645. https:\/\/doi.org\/10.1016\/j.bbamem.2007.10.018","journal-title":"Biochim Biophys Acta (BBA)"},{"key":"4498_CR167","doi-asserted-by":"publisher","first-page":"2435","DOI":"10.1242\/jcs.01235","volume":"117","author":"K Turksen","year":"2004","unstructured":"Turksen K, Troy T-C (2004) Barriers built on claudins. J Cell Sci 117:2435\u20132447. https:\/\/doi.org\/10.1242\/jcs.01235","journal-title":"J Cell Sci"},{"key":"4498_CR168","doi-asserted-by":"publisher","first-page":"829","DOI":"10.3389\/fcell.2021.625719","volume":"9","author":"S Ch\u00e1nez-Paredes","year":"2021","unstructured":"Ch\u00e1nez-Paredes S, Montoya-Garc\u00eda A, Castro-Ochoa KF et al (2021) The Arp2\/3 inhibitory protein arpin is required for intestinal epithelial barrier integrity. Front Cell Dev Biol 9:829","journal-title":"Front Cell Dev Biol"},{"key":"4498_CR169","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1186\/s40168-020-00920-y","volume":"8","author":"H Shi","year":"2020","unstructured":"Shi H, Yu Y, Lin D et al (2020) \u03b2-glucan attenuates cognitive impairment via the gut-brain axis in diet-induced obese mice. Microbiome 8:143. https:\/\/doi.org\/10.1186\/s40168-020-00920-y","journal-title":"Microbiome"},{"key":"4498_CR170","doi-asserted-by":"publisher","first-page":"e36095","DOI":"10.1371\/journal.pone.0036095","volume":"7","author":"A Gomez","year":"2012","unstructured":"Gomez A, Luckey D, Yeoman CJ et al (2012) Loss of sex and age driven differences in the gut microbiome characterize arthritis-susceptible 0401 mice but not arthritis-resistant 0402 mice. PLoS ONE 7:e36095","journal-title":"PLoS ONE"},{"key":"4498_CR171","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1152\/physrev.00003.2008","volume":"91","author":"A Fasano","year":"2011","unstructured":"Fasano A (2011) Zonulin and its regulation of intestinal barrier function: the biological door to inflammation, autoimmunity, and cancer. Physiol Rev 91:151\u2013175","journal-title":"Physiol Rev"},{"key":"4498_CR172","doi-asserted-by":"publisher","first-page":"1995","DOI":"10.1038\/s41467-020-15831-7","volume":"11","author":"N Tajik","year":"2020","unstructured":"Tajik N, Frech M, Schulz O et al (2020) Targeting zonulin and intestinal epithelial barrier function to prevent onset of arthritis. Nat Commun 11:1995. https:\/\/doi.org\/10.1038\/s41467-020-15831-7","journal-title":"Nat Commun"},{"key":"4498_CR173","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1136\/annrheumdis-2016-210000","volume":"76","author":"F Ciccia","year":"2017","unstructured":"Ciccia F, Guggino G, Rizzo A et al (2017) Dysbiosis and zonulin upregulation alter gut epithelial and vascular barriers in patients with ankylosing spondylitis. Ann Rheum Dis 76:1123. https:\/\/doi.org\/10.1136\/annrheumdis-2016-210000","journal-title":"Ann Rheum Dis"},{"key":"4498_CR174","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1016\/j.berh.2018.08.012","volume":"31","author":"A Rizzo","year":"2017","unstructured":"Rizzo A, Ferrante A, Guggino G et al (2017) Gut inflammation in spondyloarthritis. Best Pract Res Clin Rheumatol 31:863\u2013876. https:\/\/doi.org\/10.1016\/j.berh.2018.08.012","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"4498_CR175","doi-asserted-by":"publisher","first-page":"1496","DOI":"10.1021\/acs.jafc.0c06329","volume":"69","author":"Y Chen","year":"2021","unstructured":"Chen Y, Yang B, Stanton C et al (2021) Bifidobacterium pseudocatenulatum ameliorates DSS-induced colitis by maintaining intestinal mechanical barrier, blocking proinflammatory cytokines, inhibiting TLR4\/NF-\u03baB signaling, and altering gut microbiota. J Agric Food Chem 69:1496\u20131512. https:\/\/doi.org\/10.1021\/acs.jafc.0c06329","journal-title":"J Agric Food Chem"},{"key":"4498_CR176","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1039\/D0FO02794D","volume":"12","author":"Y Gao","year":"2021","unstructured":"Gao Y, Liu Y, Ma F et al (2021) Lactobacillus plantarum Y44 alleviates oxidative stress by regulating gut microbiota and colonic barrier function in Balb\/C mice with subcutaneous d-galactose injection. Food Funct 12:373\u2013386. https:\/\/doi.org\/10.1039\/D0FO02794D","journal-title":"Food Funct"},{"key":"4498_CR177","doi-asserted-by":"publisher","first-page":"5645","DOI":"10.2147\/DDDT.S284422","volume":"14","author":"T Hu","year":"2020","unstructured":"Hu T, Wang H, Xiang C et al (2020) Lactobacillus acidophilus preventive effect of XY27 on DSS-induced ulcerative colitis in mice. Drug Des Devel Ther 14:5645\u20135657. https:\/\/doi.org\/10.2147\/DDDT.S284422","journal-title":"Drug Des Devel Ther"},{"key":"4498_CR178","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.imlet.2019.10.009","volume":"216","author":"H Jia","year":"2019","unstructured":"Jia H, Ren S, Wang X (2019) Heat-killed probiotic regulates the body\u2019s regulatory immunity to attenuate subsequent experimental autoimmune arthritis. Immunol Lett 216:89\u201396. https:\/\/doi.org\/10.1016\/j.imlet.2019.10.009","journal-title":"Immunol Lett"},{"key":"4498_CR179","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.imlet.2020.10.008","volume":"228","author":"J Jhun","year":"2020","unstructured":"Jhun J, Min H-K, Na HS et al (2020) Combinatmarion treatment with Lactobacillus acidophilus LA-1, vitamin B, and curcumin ameliorates the progression of osteoarthritis by inhibiting the pro-inflammatory mediators. Immunol Lett 228:112\u2013121. https:\/\/doi.org\/10.1016\/j.imlet.2020.10.008","journal-title":"Immunol Lett"},{"key":"4498_CR180","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.3389\/fmicb.2017.01159","volume":"8","author":"M Yamashita","year":"2017","unstructured":"Yamashita M, Matsumoto K, Endo T et al (2017) Preventive effect of Lactobacillus helveticus SBT2171 on collagen-induced arthritis in mice. Front Microbiol 8:1159","journal-title":"Front Microbiol"},{"key":"4498_CR181","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-021-00440-6","author":"S Salminen","year":"2021","unstructured":"Salminen S, Collado MC, Endo A et al (2021) The International Scientific Association of Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics. Nat Rev Gastroenterol Hepatol. https:\/\/doi.org\/10.1038\/s41575-021-00440-6","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"4498_CR182","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s00005-020-00581-7","volume":"68","author":"B Nowak","year":"2020","unstructured":"Nowak B, \u015ar\u00f3ttek M, Ciszek-Lenda M et al (2020) Exopolysaccharide from Lactobacillus rhamnosus KL37 Inhibits T Cell-dependent Immune Response in Mice. Arch Immunol Ther Exp 68:17. https:\/\/doi.org\/10.1007\/s00005-020-00581-7","journal-title":"Arch Immunol Ther Exp"},{"key":"4498_CR183","doi-asserted-by":"publisher","DOI":"10.3390\/nu10101537","author":"Y Liu","year":"2018","unstructured":"Liu Y, Alookaran JJ, Rhoads JM (2018) Probiotics in autoimmune and inflammatory disorders. Nutrients. https:\/\/doi.org\/10.3390\/nu10101537","journal-title":"Nutrients"},{"key":"4498_CR184","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1038\/nbt.2487","volume":"31","author":"Y Liu","year":"2013","unstructured":"Liu Y, Aryee MJ, Padyukov L et al (2013) Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis. Nat Biotechnol 31:142\u2013147. https:\/\/doi.org\/10.1038\/nbt.2487","journal-title":"Nat Biotechnol"},{"key":"4498_CR185","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.molimm.2020.08.002","volume":"127","author":"Y Huang","year":"2020","unstructured":"Huang Y, Wang H, Ba X et al (2020) Decipher manifestations and Treg \/Th17 imbalance in multi-staging rheumatoid arthritis and correlation with TSDR\/RORC methylation. Mol Immunol 127:1\u201311. https:\/\/doi.org\/10.1016\/j.molimm.2020.08.002","journal-title":"Mol Immunol"},{"key":"4498_CR186","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1002\/acr2.11231","volume":"3","author":"R Ai","year":"2021","unstructured":"Ai R, Boyle DL, Wang W et al (2021) Distinct DNA methylation patterns of rheumatoid arthritis peripheral blood and synovial tissue T cells. ACR Open Rheumatol 3:127\u2013132. https:\/\/doi.org\/10.1002\/acr2.11231","journal-title":"ACR Open Rheumatol"},{"key":"4498_CR187","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1189\/jlb.0611286","volume":"92","author":"D Ghadimi","year":"2012","unstructured":"Ghadimi D, Helwig U, Schrezenmeir J et al (2012) Epigenetic imprinting by commensal probiotics inhibits the IL-23\/IL-17 axis in an in vitro model of the intestinal mucosal immune system. J Leukoc Biol 92:895\u2013911. https:\/\/doi.org\/10.1189\/jlb.0611286","journal-title":"J Leukoc Biol"},{"key":"4498_CR188","doi-asserted-by":"publisher","first-page":"35755","DOI":"10.1074\/jbc.M111.271007","volume":"286","author":"K Takahashi","year":"2011","unstructured":"Takahashi K, Sugi Y, Nakano K et al (2011) Epigenetic control of the host gene by commensal bacteria in large intestinal epithelial cells. J Biol Chem 286:35755\u201335762","journal-title":"J Biol Chem"},{"key":"4498_CR189","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1038\/s41590-020-0650-4","volume":"21","author":"Z Shulman","year":"2020","unstructured":"Shulman Z, Stern-Ginossar N (2020) The RNA modification N6-methyladenosine as a novel regulator of the immune system. Nat Immunol 21:501\u2013512. https:\/\/doi.org\/10.1038\/s41590-020-0650-4","journal-title":"Nat Immunol"},{"key":"4498_CR190","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/5735279","author":"Q Luo","year":"2020","unstructured":"Luo Q, Gao Y, Zhang L et al (2020) Decreased ALKBH5, FTO, and YTHDF2 in peripheral blood are as risk factors for rheumatoid arthritis. Biomed Res Int. https:\/\/doi.org\/10.1155\/2020\/5735279","journal-title":"Biomed Res Int"},{"key":"4498_CR191","doi-asserted-by":"publisher","first-page":"575","DOI":"10.2147\/JIR.S296006","volume":"14","author":"H Jiang","year":"2021","unstructured":"Jiang H, Cao K, Fan C et al (2021) Transcriptome-wide high-throughput m6A sequencing of differential m6A methylation patterns in the human rheumatoid arthritis fibroblast-like synoviocytes cell line MH7A. J Inflamm Res 14:575","journal-title":"J Inflamm Res"},{"key":"4498_CR192","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1038\/s41467-020-15126-x","volume":"11","author":"S Jabs","year":"2020","unstructured":"Jabs S, Biton A, B\u00e9cavin C et al (2020) Impact of the gut microbiota on the m6A epitranscriptome of mouse cecum and liver. Nat Commun 11:1344. https:\/\/doi.org\/10.1038\/s41467-020-15126-x","journal-title":"Nat Commun"},{"key":"4498_CR193","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1136\/annrheumdis-2019-216794","volume":"80","author":"A Suzuki","year":"2021","unstructured":"Suzuki A, Guerrini MM, Yamamoto K (2021) Functional genomics of autoimmune diseases. Ann Rheum Dis 80:689. https:\/\/doi.org\/10.1136\/annrheumdis-2019-216794","journal-title":"Ann Rheum Dis"},{"key":"4498_CR194","doi-asserted-by":"publisher","first-page":"126","DOI":"10.3389\/fimmu.2021.633201","volume":"12","author":"CC Cunningham","year":"2021","unstructured":"Cunningham CC, Wade S, Floudas A et al (2021) Serum miRNA signature in rheumatoid arthritis and \u201cat-risk individuals.\u201d Front Immunol 12:126","journal-title":"Front Immunol"},{"key":"4498_CR195","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21124301","author":"S-H Lin","year":"2020","unstructured":"Lin S-H, Ho J-C, Li S-C et al (2020) Upregulation of miR-941 in circulating CD14+ monocytes enhances osteoclast activation via WNT16 inhibition in patients with psoriatic arthritis. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms21124301","journal-title":"Int J Mol Sci"},{"key":"4498_CR196","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1136\/annrheumdis-2016-210175","volume":"76","author":"L Chen","year":"2017","unstructured":"Chen L, Al-Mossawi MH, Ridley A et al (2017) miR-10b-5p is a novel Th17 regulator present in Th17 cells from ankylosing spondylitis. Ann Rheum Dis 76:620. https:\/\/doi.org\/10.1136\/annrheumdis-2016-210175","journal-title":"Ann Rheum Dis"},{"key":"4498_CR197","doi-asserted-by":"publisher","first-page":"952","DOI":"10.3389\/fcell.2020.551681","volume":"8","author":"Y Rao","year":"2020","unstructured":"Rao Y, Fang Y, Tan W et al (2020) Delivery of long non-coding RNA NEAT1 by peripheral blood monouclear cells-derived exosomes promotes the occurrence of rheumatoid arthritis via the MicroRNA-23a\/MDM2\/SIRT6 Axis. Front Cell Dev Biol 8:952","journal-title":"Front Cell Dev Biol"},{"key":"4498_CR198","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s13000-019-0783-7","volume":"14","author":"X Tang","year":"2019","unstructured":"Tang X, Wang J, Xia X et al (2019) Elevated expression of ciRS-7 in peripheral blood mononuclear cells from rheumatoid arthritis patients. Diagn Pathol 14:11. https:\/\/doi.org\/10.1186\/s13000-019-0783-7","journal-title":"Diagn Pathol"},{"key":"4498_CR199","doi-asserted-by":"publisher","first-page":"1700144","DOI":"10.1002\/mnfr.201700144","volume":"61","author":"A Rodr\u00edguez-Nogales","year":"2017","unstructured":"Rodr\u00edguez-Nogales A, Algieri F, Garrido-Mesa J et al (2017) Differential intestinal anti-inflammatory effects of Lactobacillus fermentum and Lactobacillus salivarius in DSS mouse colitis: impact on microRNAs expression and microbiota composition. Mol Nutr Food Res 61:1700144. https:\/\/doi.org\/10.1002\/mnfr.201700144","journal-title":"Mol Nutr Food Res"},{"key":"4498_CR200","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.4014\/jmb.2002.02059","volume":"30","author":"Q Hou","year":"2020","unstructured":"Hou Q, Huang Y, Wang Y et al (2020) Lactobacillus casei LC01 regulates intestinal epithelial permeability through miR-144 targeting of OCLN and ZO1. J Microbiol Biotechnol 30:1480\u20131487. https:\/\/doi.org\/10.4014\/jmb.2002.02059","journal-title":"J Microbiol Biotechnol"},{"key":"4498_CR201","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1038\/nrg.2016.20","volume":"17","author":"DW Thomson","year":"2016","unstructured":"Thomson DW, Dinger ME (2016) Endogenous microRNA sponges: evidence and controversy. Nat Rev Genet 17:272\u2013283. https:\/\/doi.org\/10.1038\/nrg.2016.20","journal-title":"Nat Rev Genet"},{"key":"4498_CR202","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynstr.2020.100216","volume":"12","author":"P Tian","year":"2020","unstructured":"Tian P, O\u2019Riordan KJ, Lee Y-K et al (2020) Towards a psychobiotic therapy for depression: Bifidobacterium breve CCFM1025 reverses chronic stress-induced depressive symptoms and gut microbial abnormalities in mice. Neurobiol Stress 12:100216. https:\/\/doi.org\/10.1016\/j.ynstr.2020.100216","journal-title":"Neurobiol Stress"},{"key":"4498_CR203","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.ijdevneu.2010.02.007","volume":"28","author":"S Bhanja","year":"2010","unstructured":"Bhanja S, Mohanakumar KP (2010) Early-life treatment of antiserotonin antibodies alters sensitivity to serotonin receptors, nociceptive stimulus and serotonin metabolism in adult rats. Int J Dev Neurosci 28:317\u2013324. https:\/\/doi.org\/10.1016\/j.ijdevneu.2010.02.007","journal-title":"Int J Dev Neurosci"},{"key":"4498_CR204","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1007\/s11926-012-0314-y","volume":"15","author":"N Yeoh","year":"2013","unstructured":"Yeoh N, Burton JP, Suppiah P et al (2013) The role of the microbiome in rheumatic diseases. Curr Rheumatol Rep 15:314. https:\/\/doi.org\/10.1007\/s11926-012-0314-y","journal-title":"Curr Rheumatol Rep"},{"key":"4498_CR205","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1016\/j.cmet.2021.05.005","volume":"33","author":"NMJ Hanssen","year":"2021","unstructured":"Hanssen NMJ, de Vos WM, Nieuwdorp M (2021) Fecal microbiota transplantation in human metabolic diseases: from a murky past to a bright future? Cell Metab 33:1098\u20131110. https:\/\/doi.org\/10.1016\/j.cmet.2021.05.005","journal-title":"Cell Metab"},{"key":"4498_CR206","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1038\/s41575-021-00441-5","volume":"18","author":"C Danne","year":"2021","unstructured":"Danne C, Rolhion N, Sokol H (2021) Recipient factors in faecal microbiota transplantation: one stool does not fit all. Nat Rev Gastroenterol Hepatol 18:503\u2013513. https:\/\/doi.org\/10.1038\/s41575-021-00441-5","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"4498_CR207","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1002\/ccr3.3677","volume":"9","author":"J Zeng","year":"2021","unstructured":"Zeng J, Peng L, Zheng W et al (2021) Fecal microbiota transplantation for rheumatoid arthritis: a case report. Clin Case Rep 9:906\u2013909. https:\/\/doi.org\/10.1002\/ccr3.3677","journal-title":"Clin Case Rep"},{"key":"4498_CR208","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1136\/annrheumdis-2020-219511","volume":"80","author":"MS Kragsnaes","year":"2021","unstructured":"Kragsnaes MS, Kjeldsen J, Horn HC et al (2021) Safety and efficacy of faecal microbiota transplantation for active peripheral psoriatic arthritis: an exploratory randomised placebo-controlled trial. Ann Rheum Dis 80:1158. https:\/\/doi.org\/10.1136\/annrheumdis-2020-219511","journal-title":"Ann Rheum Dis"}],"container-title":["Cellular and Molecular Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-022-04498-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00018-022-04498-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-022-04498-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T12:22:50Z","timestamp":1663244570000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00018-022-04498-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,6]]},"references-count":208,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["4498"],"URL":"https:\/\/doi.org\/10.1007\/s00018-022-04498-6","relation":{},"ISSN":["1420-682X","1420-9071"],"issn-type":[{"value":"1420-682X","type":"print"},{"value":"1420-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,6]]},"assertion":[{"value":"20 June 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 July 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 July 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 August 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"The manuscript does not contain human research, and any individual person\u2019s data in any form (including any individual details, images or videos).","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"470"}}