{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:48:57Z","timestamp":1787849337188,"version":"build-2784847793"},"reference-count":83,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T00:00:00Z","timestamp":1662940800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T00:00:00Z","timestamp":1662940800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB1123-A3"],"award-info":[{"award-number":["SFB1123-A3"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB1123-A3"],"award-info":[{"award-number":["SFB1123-A3"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB1123-A2"],"award-info":[{"award-number":["SFB1123-A2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB1123-A1"],"award-info":[{"award-number":["SFB1123-A1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB1123-Z1"],"award-info":[{"award-number":["SFB1123-Z1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB1123-B5"],"award-info":[{"award-number":["SFB1123-B5"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB240-B01 (374031971 \u2013 TRR 240)"],"award-info":[{"award-number":["SFB240-B01 (374031971 \u2013 TRR 240)"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DFG INST 409\/209-1 FUGG"],"award-info":[{"award-number":["DFG INST 409\/209-1 FUGG"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["EXC 2145 SyNergy\u2014ID 390857198"],"award-info":[{"award-number":["EXC 2145 SyNergy\u2014ID 390857198"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["EXC 2145 SyNergy\u2014ID 390857198"],"award-info":[{"award-number":["EXC 2145 SyNergy\u2014ID 390857198"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["EXC 2145 SyNergy\u2014ID 390857198"],"award-info":[{"award-number":["EXC 2145 SyNergy\u2014ID 390857198"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB1123-B6"],"award-info":[{"award-number":["SFB1123-B6"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009401","name":"Medizinischen Fakult\u00e4t, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","doi-asserted-by":"publisher","award":["Metiphys scholarship of LMU Munich"],"award-info":[{"award-number":["Metiphys scholarship of LMU Munich"]}],"id":[{"id":"10.13039\/501100009401","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009401","name":"Medizinischen Fakult\u00e4t, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","doi-asserted-by":"publisher","award":["F\u00f6FoLe"],"award-info":[{"award-number":["F\u00f6FoLe"]}],"id":[{"id":"10.13039\/501100009401","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008426","name":"Friedrich-Baur-Stiftung","doi-asserted-by":"publisher","award":["AH2020"],"award-info":[{"award-number":["AH2020"]}],"id":[{"id":"10.13039\/501100008426","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Universit\u00e4tsklinik M\u00fcnchen"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell. Mol. Life Sci."],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>To fulfil its orchestration of immune cell trafficking, a network of chemokines and receptors developed that capitalizes on specificity, redundancy, and functional selectivity. The discovery of heteromeric interactions in the chemokine interactome has expanded the complexity within this network. Moreover, some inflammatory mediators, not structurally linked to classical chemokines, bind to chemokine receptors and behave as atypical chemokines (ACKs). We identified macrophage migration inhibitory factor (MIF) as an ACK that binds to chemokine receptors CXCR2 and CXCR4 to promote atherogenic leukocyte recruitment. Here, we hypothesized that chemokine\u2013chemokine interactions extend to ACKs and that MIF forms heterocomplexes with classical chemokines. We tested this hypothesis by using an unbiased chemokine protein array. Platelet chemokine CXCL4L1 (but not its variant CXCL4 or the CXCR2\/CXCR4 ligands CXCL8 or CXCL12) was identified as a candidate interactor. MIF\/CXCL4L1 complexation was verified by co-immunoprecipitation, surface plasmon-resonance analysis, and microscale thermophoresis, also establishing high-affinity binding. We next determined whether heterocomplex formation modulates inflammatory\/atherogenic activities of MIF. Complex formation was observed to inhibit MIF-elicited T-cell chemotaxis as assessed by transwell migration assay and in a 3D-matrix-based live cell-imaging set-up. Heterocomplexation also blocked MIF-triggered migration of microglia in cortical cultures in situ, as well as MIF-mediated monocyte adhesion on aortic endothelial cell monolayers under flow stress conditions. Of note, CXCL4L1 blocked binding of Alexa-MIF to a soluble surrogate of CXCR4 and co-incubation with CXCL4L1 attenuated MIF responses in HEK293-CXCR4 transfectants, indicating that complex formation interferes with MIF\/CXCR4 pathways. Because MIF and CXCL4L1 are platelet-derived products, we finally tested their role in platelet activation. Multi-photon microscopy, FLIM-FRET, and proximity-ligation assay visualized heterocomplexes in platelet aggregates and in clinical human thrombus sections obtained from peripheral artery disease (PAD) in patients undergoing thrombectomy. Moreover, heterocomplexes inhibited MIF-stimulated thrombus formation under flow and skewed the lamellipodia phenotype of adhering platelets. Our study establishes a novel molecular interaction that adds to the complexity of the chemokine interactome and chemokine\/receptor-network. MIF\/CXCL4L1, or more generally, ACK\/CXC-motif chemokine heterocomplexes may be target structures that can be exploited to modulate inflammation and thrombosis.<\/jats:p>","DOI":"10.1007\/s00018-022-04539-0","type":"journal-article","created":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T11:03:01Z","timestamp":1662980581000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Heterocomplexes between the atypical chemokine MIF and the CXC-motif chemokine CXCL4L1 regulate inflammation and thrombus formation"],"prefix":"10.1007","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1629-8353","authenticated-orcid":false,"given":"Markus","family":"Brandhofer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7936-3848","authenticated-orcid":false,"given":"Xavier","family":"Blanchet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Siminkovitch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5469-3648","authenticated-orcid":false,"given":"Anne-Katrin","family":"Rohlfing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3051-2096","authenticated-orcid":false,"given":"Omar","family":"El Bounkari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy A.","family":"Nestele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Bild","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Kontos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Hille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Rohde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Fr\u00f6hlich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jona","family":"Golemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozgun","family":"Gokce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Krammer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7334-3096","authenticated-orcid":false,"given":"Patrick","family":"Scheiermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Tsilimparis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadja","family":"Sachs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang E.","family":"Kempf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Maegdefessel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael K.","family":"Otabil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9871-6696","authenticated-orcid":false,"given":"Remco T. A.","family":"Megens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Ippel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9955-9730","authenticated-orcid":false,"given":"Rory R.","family":"Koenen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfu","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Engelmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin H.","family":"Mayo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meinrad","family":"Gawaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aphrodite","family":"Kapurniotu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4610-8714","authenticated-orcid":false,"given":"Christian","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"von Hundelshausen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2996-2652","authenticated-orcid":false,"given":"J\u00fcrgen","family":"Bernhagen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,9,12]]},"reference":[{"key":"4539_CR1","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1038\/nm.2538","volume":"17","author":"C Weber","year":"2011","unstructured":"Weber C, Noels H (2011) Atherosclerosis: current pathogenesis and therapeutic options. Nat Med 17:1410\u20131422","journal-title":"Nat Med"},{"key":"4539_CR2","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1161\/ATVBAHA.118.312037","volume":"39","author":"H Noels","year":"2019","unstructured":"Noels H, Weber C, Koenen RR (2019) Chemokines as therapeutic targets in cardiovascular disease. Arterioscler Thromb Vasc Biol 39:583\u2013592","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"4539_CR3","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1056\/NEJMra052723","volume":"354","author":"IF Charo","year":"2006","unstructured":"Charo IF, Ransohoff RM (2006) The many roles of chemokines and chemokine receptors in inflammation. N Engl J Med 354:610\u2013621","journal-title":"N Engl J Med"},{"key":"4539_CR4","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1038\/nrd.2017.91","volume":"16","author":"CJ Hutchings","year":"2017","unstructured":"Hutchings CJ, Koglin M, Olson WC, Marshall FH (2017) Opportunities for therapeutic antibodies directed at G-protein-coupled receptors. Nat Rev Drug Discov 16:787\u2013810","journal-title":"Nat Rev Drug Discov"},{"key":"4539_CR5","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1038\/nri3049","volume":"11","author":"A Zlotnik","year":"2011","unstructured":"Zlotnik A, Burkhardt AM, Homey B (2011) Homeostatic chemokine receptors and organ-specific metastasis. Nat Rev Immunol 11:597\u2013606","journal-title":"Nat Rev Immunol"},{"key":"4539_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1124\/pr.113.007724","volume":"66","author":"F Bachelerie","year":"2014","unstructured":"Bachelerie F, Ben-Baruch A, Burkhardt AM, Combadiere C, Farber JM, Graham GJ, Horuk R, Sparre-Ulrich AH, Locati M, Luster AD, Mantovani A, Matsushima K, Murphy PM, Nibbs R, Nomiyama H, Power CA, Proudfoot AE, Rosenkilde MM, Rot A, Sozzani S, Thelen M, Yoshie O, Zlotnik A (2014) International Union of Basic and Clinical Pharmacology. [corrected]. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for atypical chemokine receptors. Pharmacol Rev 66:1\u201379","journal-title":"Pharmacol Rev"},{"key":"4539_CR7","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/ni.2812","volume":"15","author":"F Bachelerie","year":"2014","unstructured":"Bachelerie F, Graham GJ, Locati M, Mantovani A, Murphy PM, Nibbs R, Rot A, Sozzani S, Thelen M (2014) New nomenclature for atypical chemokine receptors. Nat Immunol 15:207\u2013208","journal-title":"Nat Immunol"},{"key":"4539_CR8","first-page":"145","volume":"52","author":"PM Murphy","year":"2000","unstructured":"Murphy PM, Baggiolini M, Charo IF, Hebert CA, Horuk R, Matsushima K, Miller LH, Oppenheim JJ, Power CA (2000) International union of pharmacology. XXII. Nomenclature for chemokine receptors. Pharmacol Rev 52:145\u2013176","journal-title":"Pharmacol Rev"},{"key":"4539_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2020.109862","volume":"78","author":"DS Eiger","year":"2021","unstructured":"Eiger DS, Boldizsar N, Honeycutt CC, Gardner J, Rajagopal S (2021) Biased agonism at chemokine receptors. Cell Signal 78:109862","journal-title":"Cell Signal"},{"key":"4539_CR10","doi-asserted-by":"publisher","first-page":"277","DOI":"10.3389\/fimmu.2014.00277","volume":"5","author":"A Steen","year":"2014","unstructured":"Steen A, Larsen O, Thiele S, Rosenkilde MM (2014) Biased and g protein-independent signaling of chemokine receptors. Front Immunol 5:277","journal-title":"Front Immunol"},{"key":"4539_CR11","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.bcp.2016.04.007","volume":"114","author":"AB Kleist","year":"2016","unstructured":"Kleist AB, Getschman AE, Ziarek JJ, Nevins AM, Gauthier PA, Chevigne A, Szpakowska M, Volkman BF (2016) New paradigms in chemokine receptor signal transduction: Moving beyond the two-site model. Biochem Pharmacol 114:53\u201368","journal-title":"Biochem Pharmacol"},{"key":"4539_CR12","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1038\/nri3544","volume":"13","author":"RJ Nibbs","year":"2013","unstructured":"Nibbs RJ, Graham GJ (2013) Immune regulation by atypical chemokine receptors. Nat Rev Immunol 13:815\u2013829","journal-title":"Nat Rev Immunol"},{"key":"4539_CR13","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aah6650","author":"P von Hundelshausen","year":"2017","unstructured":"von Hundelshausen P, Agten SM, Eckardt V, Blanchet X, Schmitt MM, Ippel H, Neideck C, Bidzhekov K, Leberzammer J, Wichapong K, Faussner A, Drechsler M, Grommes J, van Geffen JP, Li H, Ortega-Gomez A, Megens RT, Naumann R, Dijkgraaf I, Nicolaes GA, Doring Y, Soehnlein O, Lutgens E, Heemskerk JW, Koenen RR, Mayo KH, Hackeng TM, Weber C (2017) Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation. Sci Transl Med. https:\/\/doi.org\/10.1126\/scitranslmed.aah6650","journal-title":"Sci Transl Med"},{"key":"4539_CR14","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1038\/nm.1898","volume":"15","author":"RR Koenen","year":"2009","unstructured":"Koenen RR, von Hundelshausen P, Nesmelova IV, Zernecke A, Liehn EA, Sarabi A, Kramp BK, Piccinini AM, Paludan SR, Kowalska MA, Kungl AJ, Hackeng TM, Mayo KH, Weber C (2009) Disrupting functional interactions between platelet chemokines inhibits atherosclerosis in hyperlipidemic mice. Nat Med 15:97\u2013103","journal-title":"Nat Med"},{"key":"4539_CR15","doi-asserted-by":"publisher","first-page":"7028","DOI":"10.1074\/jbc.M109.091090","volume":"285","author":"J Rohrl","year":"2010","unstructured":"Rohrl J, Yang D, Oppenheim JJ, Hehlgans T (2010) Specific binding and chemotactic activity of mBD4 and its functional orthologue hBD2 to CCR6-expressing cells. J Biol Chem 285:7028\u20137034","journal-title":"J Biol Chem"},{"key":"4539_CR16","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1126\/science.284.5411.147","volume":"284","author":"K Wakasugi","year":"1999","unstructured":"Wakasugi K, Schimmel P (1999) Two distinct cytokines released from a human aminoacyl-tRNA synthetase. Science 284:147\u2013151","journal-title":"Science"},{"key":"4539_CR17","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3389\/fmed.2019.00003","volume":"6","author":"A Kapurniotu","year":"2019","unstructured":"Kapurniotu A, Gokce O, Bernhagen J (2019) The multitasking potential of alarmins and atypical chemokines. Front Med (Lausanne) 6:3","journal-title":"Front Med (Lausanne)"},{"key":"4539_CR18","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/S0014-5793(03)01027-5","volume":"553","author":"B Degryse","year":"2003","unstructured":"Degryse B, de Virgilio M (2003) The nuclear protein HMGB1, a new kind of chemokine? FEBS Lett 553:11\u201317","journal-title":"FEBS Lett"},{"key":"4539_CR19","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.coi.2005.06.002","volume":"17","author":"JJ Oppenheim","year":"2005","unstructured":"Oppenheim JJ, Yang D (2005) Alarmins: chemotactic activators of immune responses. Curr Opin Immunol 17:359\u2013365","journal-title":"Curr Opin Immunol"},{"key":"4539_CR20","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1073\/pnas.56.1.72","volume":"56","author":"JR David","year":"1966","unstructured":"David JR (1966) Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction. Proc Natl Acad Sci USA 56:72\u201377","journal-title":"Proc Natl Acad Sci USA"},{"key":"4539_CR21","doi-asserted-by":"publisher","first-page":"740","DOI":"10.3390\/genes10100740","volume":"10","author":"C Michelet","year":"2019","unstructured":"Michelet C, Danchin EGJ, Jaouannet M, Bernhagen J, Panstruga R, Kogel KH, Keller H, Coustau C (2019) Cross-Kingdom Analysis of Diversity, Evolutionary History, and Site Selection within the Eukaryotic Macrophage Migration Inhibitory Factor Superfamily. Genes (Basel) 10:740","journal-title":"Genes (Basel)"},{"key":"4539_CR22","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1038\/nri1200","volume":"3","author":"T Calandra","year":"2003","unstructured":"Calandra T, Roger T (2003) Macrophage migration inhibitory factor: a regulator of innate immunity. Nat Rev Immunol 3:791\u2013800","journal-title":"Nat Rev Immunol"},{"key":"4539_CR23","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1080\/14728222.2017.1336227","volume":"21","author":"PV Tilstam","year":"2017","unstructured":"Tilstam PV, Qi D, Leng L, Young L, Bucala R (2017) MIF family cytokines in cardiovascular diseases and prospects for precision-based therapeutics. Expert Opin Ther Targets 21:671\u2013683","journal-title":"Expert Opin Ther Targets"},{"key":"4539_CR24","doi-asserted-by":"publisher","first-page":"5191","DOI":"10.1073\/pnas.93.11.5191","volume":"93","author":"HW Sun","year":"1996","unstructured":"Sun HW, Bernhagen J, Bucala R, Lolis E (1996) Crystal structure at 2.6-A resolution of human macrophage migration inhibitory factor. Proc Natl Acad Sci USA 93:5191\u20135196","journal-title":"Proc Natl Acad Sci USA"},{"key":"4539_CR25","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1038\/nm1567","volume":"13","author":"J Bernhagen","year":"2007","unstructured":"Bernhagen J, Krohn R, Lue H, Gregory JL, Zernecke A, Koenen RR, Dewor M, Georgiev I, Schober A, Leng L, Kooistra T, Fingerle-Rowson G, Ghezzi P, Kleemann R, McColl SR, Bucala R, Hickey MJ, Weber C (2007) MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment. Nat Med 13:587\u2013596","journal-title":"Nat Med"},{"key":"4539_CR26","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1055\/s-0039-1677803","volume":"119","author":"D Sinitski","year":"2019","unstructured":"Sinitski D, Kontos C, Krammer C, Asare Y, Kapurniotu A, Bernhagen J (2019) Macrophage migration inhibitory factor (MIF)-based therapeutic concepts in atherosclerosis and inflammation. Thromb Haemost 119:553\u2013566","journal-title":"Thromb Haemost"},{"key":"4539_CR27","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1084\/jem.20030286","volume":"197","author":"L Leng","year":"2003","unstructured":"Leng L, Metz CN, Fang Y, Xu J, Donnelly S, Baugh J, Delohery T, Chen Y, Mitchell RA, Bucala R (2003) MIF signal transduction initiated by binding to CD74. J Exp Med 197:1467\u20131476","journal-title":"J Exp Med"},{"key":"4539_CR28","doi-asserted-by":"publisher","first-page":"115","DOI":"10.3389\/fimmu.2013.00115","volume":"4","author":"S Tillmann","year":"2013","unstructured":"Tillmann S, Bernhagen J, Noels H (2013) Arrest functions of the MIF ligand\/receptor axes in atherogenesis. Front Immunol 4:115","journal-title":"Front Immunol"},{"key":"4539_CR29","doi-asserted-by":"publisher","first-page":"429","DOI":"10.3389\/fimmu.2015.00429","volume":"6","author":"L Pawig","year":"2015","unstructured":"Pawig L, Klasen C, Weber C, Bernhagen J, Noels H (2015) Diversity and inter-connections in the CXCR4 chemokine receptor\/ligand family: molecular perspectives. Front Immunol 6:429","journal-title":"Front Immunol"},{"key":"4539_CR30","doi-asserted-by":"publisher","first-page":"5273","DOI":"10.4049\/jimmunol.1302209","volume":"192","author":"C Klasen","year":"2014","unstructured":"Klasen C, Ohl K, Sternkopf M, Shachar I, Schmitz C, Heussen N, Hobeika E, Levit-Zerdoun E, Tenbrock K, Reth M, Bernhagen J, El Bounkari O (2014) MIF promotes B cell chemotaxis through the receptors CXCR4 and CD74 and ZAP-70 signaling. J Immunol 192:5273\u20135284","journal-title":"J Immunol"},{"key":"4539_CR31","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1096\/fj.10-168559","volume":"25","author":"S Kraemer","year":"2011","unstructured":"Kraemer S, Lue H, Zernecke A, Kapurniotu A, Andreetto E, Frank R, Lennartz B, Weber C, Bernhagen J (2011) MIF-chemokine receptor interactions in atherogenesis are dependent on an N-loop-based 2-site binding mechanism. Faseb J 25:894\u2013906","journal-title":"FASEB J"},{"key":"4539_CR32","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1002\/cbic.202000574","volume":"22","author":"C Krammer","year":"2021","unstructured":"Krammer C, Kontos C, Dewor M, Hille K, Dalla Volta B, El Bounkari O, Tas K, Sinitski D, Brandhofer M, Megens RTA, Weber C, Schultz JR, Bernhagen J, Kapurniotu A (2021) A MIF-derived cyclopeptide that inhibits MIF binding and atherogenic signaling via the chemokine receptor CXCR2. ChemBioChem 22:1012\u20131019","journal-title":"ChemBioChem"},{"key":"4539_CR33","doi-asserted-by":"publisher","first-page":"5171","DOI":"10.1038\/s41598-018-23554-5","volume":"8","author":"M Lacy","year":"2018","unstructured":"Lacy M, Kontos C, Brandhofer M, Hille K, Groning S, Sinitski D, Bourilhon P, Rosenberg E, Krammer C, Thavayogarajah T, Pantouris G, Bakou M, Weber C, Lolis E, Bernhagen J, Kapurniotu A (2018) Identification of an Arg-Leu-Arg tripeptide that contributes to the binding interface between the cytokine MIF and the chemokine receptor CXCR4. Sci Rep 8:5171","journal-title":"Sci Rep"},{"key":"4539_CR34","doi-asserted-by":"publisher","first-page":"15881","DOI":"10.1074\/jbc.M116.717751","volume":"291","author":"D Rajasekaran","year":"2016","unstructured":"Rajasekaran D, Groning S, Schmitz C, Zierow S, Drucker N, Bakou M, Kohl K, Mertens A, Lue H, Weber C, Xiao A, Luker G, Kapurniotu A, Lolis E, Bernhagen J (2016) Macrophage migration inhibitory factor-CXCR4 receptor interactions: evidence for partial allosteric agonism in comparison with CXCL12 chemokine. J Biol Chem 291:15881\u201315895","journal-title":"J Biol Chem"},{"key":"4539_CR35","doi-asserted-by":"publisher","first-page":"16278","DOI":"10.1073\/pnas.0804017105","volume":"105","author":"C Weber","year":"2008","unstructured":"Weber C, Kraemer S, Drechsler M, Lue H, Koenen RR, Kapurniotu A, Zernecke A, Bernhagen J (2008) Structural determinants of MIF functions in CXCR2-mediated inflammatory and atherogenic leukocyte recruitment. Proc Natl Acad Sci USA 105:16278\u201316283","journal-title":"Proc Natl Acad Sci USA"},{"key":"4539_CR36","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201947852","volume":"21","author":"V Eckardt","year":"2020","unstructured":"Eckardt V, Miller MC, Blanchet X, Duan R, Leberzammer J, Duchene J, Soehnlein O, Megens RT, Ludwig AK, Dregni A, Faussner A, Wichapong K, Ippel H, Dijkgraaf I, Kaltner H, Doring Y, Bidzhekov K, Hackeng TM, Weber C, Gabius HJ, von Hundelshausen P, Mayo KH (2020) Chemokines and galectins form heterodimers to modulate inflammation. EMBO Rep 21:e47852","journal-title":"EMBO Rep"},{"key":"4539_CR37","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1084\/jem.20111739","volume":"209","author":"M Schiraldi","year":"2012","unstructured":"Schiraldi M, Raucci A, Munoz LM, Livoti E, Celona B, Venereau E, Apuzzo T, De Marchis F, Pedotti M, Bachi A, Thelen M, Varani L, Mellado M, Proudfoot A, Bianchi ME, Uguccioni M (2012) HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4. J Exp Med 209:551\u2013563","journal-title":"J Exp Med"},{"key":"4539_CR38","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201947788","volume":"20","author":"F De Leo","year":"2019","unstructured":"De Leo F, Quilici G, Tirone M, De Marchis F, Mannella V, Zucchelli C, Preti A, Gori A, Casalgrandi M, Mezzapelle R, Bianchi ME, Musco G (2019) Diflunisal targets the HMGB1\/CXCL12 heterocomplex and blocks immune cell recruitment. EMBO Rep 20:e47788","journal-title":"EMBO Rep"},{"key":"4539_CR39","doi-asserted-by":"publisher","first-page":"14144","DOI":"10.1021\/bi00251a025","volume":"33","author":"J Bernhagen","year":"1994","unstructured":"Bernhagen J, Mitchell RA, Calandra T, Voelter W, Cerami A, Bucala R (1994) Purification, bioactivity, and secondary structure analysis of mouse and human macrophage migration Inhibitory factor (MIF). Biochemistry 33:14144\u201314155","journal-title":"Biochemistry"},{"key":"4539_CR40","doi-asserted-by":"publisher","first-page":"5981","DOI":"10.1038\/s41467-020-19764-z","volume":"11","author":"C Kontos","year":"2020","unstructured":"Kontos C, El Bounkari O, Krammer C, Sinitski D, Hille K, Zan C, Yan G, Wang S, Gao Y, Brandhofer M, Megens RTA, Hoffmann A, Pauli J, Asare Y, Gerra S, Bourilhon P, Leng L, Eckstein HH, Kempf WE, Pelisek J, Gokce O, Maegdefessel L, Bucala R, Dichgans M, Weber C, Kapurniotu A, Bernhagen J (2020) Designed CXCR4 mimic acts as a soluble chemokine receptor that blocks atherogenic inflammation by agonist-specific targeting. Nat Commun 11:5981","journal-title":"Nat Commun"},{"key":"4539_CR41","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1002\/ijc.2910410324","volume":"41","author":"HW Ziegler-Heitbrock","year":"1988","unstructured":"Ziegler-Heitbrock HW, Thiel E, Futterer A, Herzog V, Wirtz A, Riethmuller G (1988) Establishment of a human cell line (Mono Mac 6) with characteristics of mature monocytes. Int J Cancer 41:456\u2013461","journal-title":"Int J Cancer"},{"key":"4539_CR42","first-page":"61","volume":"31","author":"B Polack","year":"2001","unstructured":"Polack B, Schved JF, Boneu B, Groupe d\u2019Etude sur l\u2019Hemostase et la, T (2001) Preanalytical recommendations of the \u201cGroupe d\u2019Etude sur l\u2019Hemostase et la Thrombose\u201d (GEHT) for venous blood testing in hemostasis laboratories. Haemostasis 31:61\u201368","journal-title":"Haemostasis"},{"key":"4539_CR43","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1182\/blood-2011-06-359976","volume":"119","author":"O Borst","year":"2012","unstructured":"Borst O, Schmidt EM, Munzer P, Schonberger T, Towhid ST, Elvers M, Leibrock C, Schmid E, Eylenstein A, Kuhl D, May AE, Gawaz M, Lang F (2012) The serum- and glucocorticoid-inducible kinase 1 (SGK1) influences platelet calcium signaling and function by regulation of Orai1 expression in megakaryocytes. Blood 119:251\u2013261","journal-title":"Blood"},{"key":"4539_CR44","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1126\/science.1102901","volume":"307","author":"JH Niess","year":"2005","unstructured":"Niess JH, Brand S, Gu X, Landsman L, Jung S, McCormick BA, Vyas JM, Boes M, Ploegh HL, Fox JG, Littman DR, Reinecker HC (2005) CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science 307:254\u2013258","journal-title":"Science"},{"key":"4539_CR45","doi-asserted-by":"publisher","first-page":"14617","DOI":"10.1523\/JNEUROSCI.1232-13.2013","volume":"33","author":"O Gokce","year":"2013","unstructured":"Gokce O, Sudhof TC (2013) Membrane-tethered monomeric neurexin LNS-domain triggers synapse formation. J Neurosci 33:14617\u201314628","journal-title":"J Neurosci"},{"key":"4539_CR46","doi-asserted-by":"publisher","first-page":"2046","DOI":"10.1073\/pnas.0507471103","volume":"103","author":"LM Yan","year":"2006","unstructured":"Yan LM, Tatarek-Nossol M, Velkova A, Kazantzis A, Kapurniotu A (2006) Design of a mimic of nonamyloidogenic and bioactive human islet amyloid polypeptide (IAPP) as nanomolar affinity inhibitor of IAPP cytotoxic fibrillogenesis. Proc Natl Acad Sci USA 103:2046\u20132051","journal-title":"Proc Natl Acad Sci USA"},{"key":"4539_CR47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/9780470559277.ch090102","volume":"1","author":"NJ Moerke","year":"2009","unstructured":"Moerke NJ (2009) Fluorescence polarization (FP) assays for monitoring peptide-protein or nucleic acid-protein binding. Curr Protoc Chem Biol 1:1\u201315","journal-title":"Curr Protoc Chem Biol"},{"key":"4539_CR48","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1038\/nbt.1671","volume":"28","author":"R Schroder","year":"2010","unstructured":"Schroder R, Janssen N, Schmidt J, Kebig A, Merten N, Hennen S, Muller A, Blattermann S, Mohr-Andra M, Zahn S, Wenzel J, Smith NJ, Gomeza J, Drewke C, Milligan G, Mohr K, Kostenis E (2010) Deconvolution of complex G protein-coupled receptor signaling in live cells using dynamic mass redistribution measurements. Nat Biotechnol 28:943\u2013949","journal-title":"Nat Biotechnol"},{"key":"4539_CR49","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/nprot.2016.169","volume":"12","author":"D Kozakov","year":"2017","unstructured":"Kozakov D, Hall DR, Xia B, Porter KA, Padhorny D, Yueh C, Beglov D, Vajda S (2017) The ClusPro web server for protein-protein docking. Nat Protoc 12:255\u2013278","journal-title":"Nat Protoc"},{"key":"4539_CR50","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1002\/prot.25219","volume":"85","author":"S Vajda","year":"2017","unstructured":"Vajda S, Yueh C, Beglov D, Bohnuud T, Mottarella SE, Xia B, Hall DR, Kozakov D (2017) New additions to the ClusPro server motivated by CAPRI. Proteins 85:435\u2013444","journal-title":"Proteins"},{"issue":"6","key":"4539_CR51","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1038\/nm.2749","volume":"18","author":"T Shichita","year":"2012","unstructured":"Shichita T, Hasegawa E, Kimura A, Morita R, Sakaguchi R, Takada I, Sekiya T, Ooboshi H, Kitazono T, Yanagawa T, Ishii T, Takahashi H, Mori S, Nishibori M, Kuroda K, Akira S, Miyake K, Yoshimura A (2012) Nat Med 18(6):911\u20137. https:\/\/doi.org\/10.1038\/nm.2749","journal-title":"Nat Med"},{"key":"4539_CR52","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.freeradbiomed.2019.04.012","volume":"137","author":"Y He","year":"2019","unstructured":"He Y, Li S, Tang D, Peng Y, Meng J, Peng S, Deng Z, Qiu S, Liao X, Chen H, Tu S, Tao L, Peng Z, Yang H (2019) Free Radic Biol Med 137:24\u201336. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2019.04.012","journal-title":"Free Radic Biol Med"},{"key":"4539_CR53","doi-asserted-by":"publisher","first-page":"e13549","DOI":"10.14814\/phy2.13549","volume":"5","author":"F Ma","year":"2017","unstructured":"Ma F, Kouzoukas DE, Meyer-Siegler KL, Hunt DE, Leng L, Bucala R, Vera PL (2017) Macrophage migration inhibitory factor mediates protease-activated receptor 4-induced bladder pain through urothelial high mobility group box 1. Physiol Rep 5:e13549","journal-title":"Physiol Rep"},{"key":"4539_CR54","doi-asserted-by":"publisher","first-page":"30653","DOI":"10.1074\/jbc.M112.385583","volume":"287","author":"F Bai","year":"2012","unstructured":"Bai F, Asojo OA, Cirillo P, Ciustea M, Ledizet M, Aristoff PA, Leng L, Koski RA, Powell TJ, Bucala R, Anthony KG (2012) A novel allosteric inhibitor of macrophage migration inhibitory factor (MIF). J Biol Chem 287:30653\u201330663","journal-title":"J Biol Chem"},{"key":"4539_CR55","doi-asserted-by":"publisher","first-page":"13522","DOI":"10.1074\/jbc.M113.455329","volume":"288","author":"JH Kuo","year":"2013","unstructured":"Kuo JH, Chen YP, Liu JS, Dubrac A, Quemener C, Prats H, Bikfalvi A, Wu WG, Sue SC (2013) Alternative C-terminal helix orientation alters chemokine function: structure of the anti-angiogenic chemokine, CXCL4L1. J Biol Chem 288:13522\u201313533","journal-title":"J Biol Chem"},{"key":"4539_CR56","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/S0014-5793(98)00400-1","volume":"427","author":"R Mischke","year":"1998","unstructured":"Mischke R, Kleemann R, Brunner H, Bernhagen J (1998) Cross-linking and mutational analysis of the oligomerization state of the cytokine macrophage migration inhibitory factor (MIF). FEBS Lett 427:85\u201390","journal-title":"FEBS Lett"},{"key":"4539_CR57","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.bpc.2003.10.010","volume":"108","author":"JS Philo","year":"2004","unstructured":"Philo JS, Yang TH, LaBarre M (2004) Re-examining the oligomerization state of macrophage migration inhibitory factor (MIF) in solution. Biophys Chem 108:77\u201387","journal-title":"Biophys Chem"},{"key":"4539_CR58","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1182\/blood-2009-11-253591","volume":"117","author":"S Struyf","year":"2011","unstructured":"Struyf S, Salogni L, Burdick MD, Vandercappellen J, Gouwy M, Noppen S, Proost P, Opdenakker G, Parmentier M, Gerard C, Sozzani S, Strieter RM, Van Damme J (2011) Angiostatic and chemotactic activities of the CXC chemokine CXCL4L1 (platelet factor-4 variant) are mediated by CXCR3. Blood 117:480\u2013488","journal-title":"Blood"},{"key":"4539_CR59","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1160\/TH07-01-0066","volume":"97","author":"P von Hundelshausen","year":"2007","unstructured":"von Hundelshausen P, Petersen F, Brandt E (2007) Platelet-derived chemokines in vascular biology. Thromb Haemost 97:704\u2013713","journal-title":"Thromb Haemost"},{"key":"4539_CR60","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1160\/TH13-04-0341","volume":"110","author":"E Karshovska","year":"2013","unstructured":"Karshovska E, Weber C, von Hundelshausen P (2013) Platelet chemokines in health and disease. Thromb Haemost 110:894\u2013902","journal-title":"Thromb Haemost"},{"key":"4539_CR61","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1160\/TH13-01-0049","volume":"110","author":"T Str\u00fc\u00dfmann","year":"2013","unstructured":"Str\u00fc\u00dfmann T, Tillmann S, Wirtz T, Bucala R, von Hundelshausen P, Bernhagen J (2013) Platelets are a previously unrecognised source of MIF. Thromb Haemost 110:1004\u20131013","journal-title":"Thromb Haemost"},{"key":"4539_CR62","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.atherosclerosis.2014.12.039","volume":"239","author":"TH Wirtz","year":"2015","unstructured":"Wirtz TH, Tillmann S, Strussmann T, Kraemer S, Heemskerk JW, Grottke O, Gawaz M, von Hundelshausen P, Bernhagen J (2015) Platelet-derived MIF: a novel platelet chemokine with distinct recruitment properties. Atherosclerosis 239:1\u201310","journal-title":"Atherosclerosis"},{"key":"4539_CR63","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1161\/CIRCRESAHA.115.305171","volume":"115","author":"M Chatterjee","year":"2014","unstructured":"Chatterjee M, Borst O, Walker B, Fotinos A, Vogel S, Seizer P, Mack A, Alampour-Rajabi S, Rath D, Geisler T, Lang F, Langer HF, Bernhagen J, Gawaz M (2014) Macrophage migration inhibitory factor limits activation-induced apoptosis of platelets via CXCR7-dependent Akt signaling. Circ Res 115:939\u2013949","journal-title":"Circ Res"},{"key":"4539_CR64","doi-asserted-by":"publisher","first-page":"2318","DOI":"10.1182\/blood.2019002105","volume":"134","author":"Y Schurr","year":"2019","unstructured":"Schurr Y, Sperr A, Volz J, Beck S, Reil L, Kusch C, Eiring P, Bryson S, Sauer M, Nieswandt B, Machesky L, Bender M (2019) Platelet lamellipodium formation is not required for thrombus formation and stability. Blood 134:2318\u20132329","journal-title":"Blood"},{"key":"4539_CR65","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1111\/jth.12834","volume":"13","author":"A Fotinos","year":"2015","unstructured":"Fotinos A, Klier M, Gowert NS, Munzer P, Klatt C, Beck S, Borst O, Billuart P, Schaller M, Lang F, Gawaz M, Elvers M (2015) Loss of oligophrenin1 leads to uncontrolled Rho activation and increased thrombus formation in mice. J Thromb Haemost 13:619\u2013630","journal-title":"J Thromb Haemost"},{"key":"4539_CR66","doi-asserted-by":"publisher","first-page":"415","DOI":"10.3109\/09537104.2011.556277","volume":"22","author":"BF Kraemer","year":"2011","unstructured":"Kraemer BF, Schmidt C, Urban B, Bigalke B, Schwanitz L, Koch M, Seizer P, Schaller M, Gawaz M, Lindemann S (2011) High shear flow induces migration of adherent human platelets. Platelets 22:415\u2013421","journal-title":"Platelets"},{"key":"4539_CR67","doi-asserted-by":"publisher","first-page":"317ra196","DOI":"10.1126\/scitranslmed.aad5330","volume":"7","author":"JE Alard","year":"2015","unstructured":"Alard JE, Ortega-Gomez A, Wichapong K, Bongiovanni D, Horckmans M, Megens RT, Leoni G, Ferraro B, Rossaint J, Paulin N, Ng J, Ippel H, Suylen D, Hinkel R, Blanchet X, Gaillard F, D\u2019Amico M, von Hundelshausen P, Zarbock A, Scheiermann C, Hackeng TM, Steffens S, Kupatt C, Nicolaes GA, Weber C, Soehnlein O (2015) Recruitment of classical monocytes can be inhibited by disturbing heteromers of neutrophil HNP1 and platelet CCL5. Sci Transl Med 7:317ra196","journal-title":"Sci Transl Med"},{"key":"4539_CR68","doi-asserted-by":"publisher","first-page":"4127","DOI":"10.1182\/blood-2006-10-052035","volume":"109","author":"L Lasagni","year":"2007","unstructured":"Lasagni L, Grepin R, Mazzinghi B, Lazzeri E, Meini C, Sagrinati C, Liotta F, Frosali F, Ronconi E, Alain-Courtois N, Ballerini L, Netti GS, Maggi E, Annunziato F, Serio M, Romagnani S, Bikfalvi A, Romagnani P (2007) PF-4\/CXCL4 and CXCL4L1 exhibit distinct subcellular localization and a differentially regulated mechanism of secretion. Blood 109:4127\u20134134","journal-title":"Blood"},{"key":"4539_CR69","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2017.08.021","volume":"122","author":"G Domschke","year":"2019","unstructured":"Domschke G, Gleissner CA (2019) CXCL4-induced macrophages in human atherosclerosis. Cytokine 122:154141","journal-title":"Cytokine"},{"key":"4539_CR70","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1111\/j.1538-7836.2010.04119.x","volume":"9","author":"A Sarabi","year":"2011","unstructured":"Sarabi A, Kramp BK, Drechsler M, Hackeng TM, Soehnlein O, Weber C, Koenen RR, Von Hundelshausen P (2011) CXCL4L1 inhibits angiogenesis and induces undirected endothelial cell migration without affecting endothelial cell proliferation and monocyte recruitment. J Thromb Haemost 9:209\u2013219","journal-title":"J Thromb Haemost"},{"key":"4539_CR71","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0166006","volume":"11","author":"M Gouwy","year":"2016","unstructured":"Gouwy M, Ruytinx P, Radice E, Claudi F, Van Raemdonck K, Bonecchi R, Locati M, Struyf S (2016) CXCL4 and CXCL4L1 differentially affect monocyte survival and dendritic cell differentiation and phagocytosis. PLoS ONE 11:e0166006","journal-title":"PLoS ONE"},{"key":"4539_CR72","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031343","volume":"7","author":"J De Sutter","year":"2012","unstructured":"De Sutter J, Van de Veire NR, Struyf S, Philippe J, De Buyzere M, Van Damme J (2012) PF-4var\/CXCL4L1 predicts outcome in stable coronary artery disease patients with preserved left ventricular function. PLoS ONE 7:e31343","journal-title":"PLoS ONE"},{"key":"4539_CR73","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1182\/blood.V76.2.336.336","volume":"76","author":"R Eisman","year":"1990","unstructured":"Eisman R, Surrey S, Ramachandran B, Schwartz E, Poncz M (1990) Structural and functional comparison of the genes for human platelet factor 4 and PF4alt. Blood 76:336\u2013344","journal-title":"Blood"},{"key":"4539_CR74","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1002\/cmdc.201500495","volume":"11","author":"M Zhou","year":"2016","unstructured":"Zhou M, Li Q, Wang R (2016) Current experimental methods for characterizing protein-protein interactions. ChemMedChem 11:738\u2013756","journal-title":"ChemMedChem"},{"key":"4539_CR75","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1111\/j.1365-2567.2010.03384.x","volume":"132","author":"A Korniejewska","year":"2011","unstructured":"Korniejewska A, McKnight AJ, Johnson Z, Watson ML, Ward SG (2011) Expression and agonist responsiveness of CXCR3 variants in human T lymphocytes. Immunology 132:503\u2013515","journal-title":"Immunology"},{"key":"4539_CR76","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1517\/14728222.2011.550879","volume":"15","author":"F Borghese","year":"2011","unstructured":"Borghese F, Clanchy FI (2011) CD74: an emerging opportunity as a therapeutic target in cancer and autoimmune disease. Expert Opin Ther Targets 15:237\u2013251","journal-title":"Expert Opin Ther Targets"},{"key":"4539_CR77","doi-asserted-by":"publisher","first-page":"10994","DOI":"10.1073\/pnas.1221817110","volume":"110","author":"C Fan","year":"2013","unstructured":"Fan C, Rajasekaran D, Syed MA, Leng L, Loria JP, Bhandari V, Bucala R, Lolis EJ (2013) MIF intersubunit disulfide mutant antagonist supports activation of CD74 by endogenous MIF trimer at physiologic concentrations. Proc Natl Acad Sci USA 110:10994\u201310999","journal-title":"Proc Natl Acad Sci USA"},{"key":"4539_CR78","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1038\/nrcardio.2011.91","volume":"8","author":"G Lippi","year":"2011","unstructured":"Lippi G, Franchini M, Targher G (2011) Arterial thrombus formation in cardiovascular disease. Nat Rev Cardiol 8:502\u2013512","journal-title":"Nat Rev Cardiol"},{"key":"4539_CR79","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1161\/01.RES.0000252802.25497.b7","volume":"100","author":"P von Hundelshausen","year":"2007","unstructured":"von Hundelshausen P, Weber C (2007) Platelets as immune cells: bridging inflammation and cardiovascular disease. Circ Res 100:27\u201340","journal-title":"Circ Res"},{"key":"4539_CR80","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.bcmd.2005.12.022","volume":"36","author":"M Gawaz","year":"2006","unstructured":"Gawaz M (2006) Platelets in the onset of atherosclerosis. Blood Cells Mol Dis 36:206\u2013210","journal-title":"Blood Cells Mol Dis"},{"key":"4539_CR81","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.atherosclerosis.2020.05.018","volume":"307","author":"H Nording","year":"2020","unstructured":"Nording H, Baron L, Langer HF (2020) Platelets as therapeutic targets to prevent atherosclerosis. Atherosclerosis 307:97\u2013108","journal-title":"Atherosclerosis"},{"key":"4539_CR82","doi-asserted-by":"publisher","first-page":"1594","DOI":"10.1161\/CIRCULATIONAHA.107.729125","volume":"117","author":"A Zernecke","year":"2008","unstructured":"Zernecke A, Bernhagen J, Weber C (2008) Macrophage migration inhibitory factor in cardiovascular disease. Circulation 117:1594\u20131602","journal-title":"Circulation"},{"key":"4539_CR83","doi-asserted-by":"publisher","first-page":"31635","DOI":"10.1074\/jbc.M113.477745","volume":"288","author":"I Muller","year":"2013","unstructured":"Muller I, Schonberger T, Schneider M, Borst O, Ziegler M, Seizer P, Leder C, Muller K, Lang M, Appenzeller F, Lunov O, Buchele B, Fahrleitner M, Olbrich M, Langer H, Geisler T, Lang F, Chatterjee M, de Boer JF, Tietge UJ, Bernhagen J, Simmet T, Gawaz M (2013) Gremlin-1 Is an inhibitor of macrophage migration inhibitory factor and attenuates atherosclerotic plaque growth in ApoE-\/- Mice. J Biol Chem 288:31635\u201331645","journal-title":"J Biol Chem"}],"container-title":["Cellular and Molecular Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-022-04539-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00018-022-04539-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-022-04539-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,30]],"date-time":"2022-10-30T07:14:09Z","timestamp":1667114049000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00018-022-04539-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,12]]},"references-count":83,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["4539"],"URL":"https:\/\/doi.org\/10.1007\/s00018-022-04539-0","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.11.26.470090","asserted-by":"object"}]},"ISSN":["1420-682X","1420-9071"],"issn-type":[{"value":"1420-682X","type":"print"},{"value":"1420-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,12]]},"assertion":[{"value":"28 January 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 August 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 September 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"J.B., P.v.H., C.K., O.E.B.,\u00a0C.W., and A.K. are inventors on patent applications related to anti-MIF and anti-chemokine strategies in inflammatory and cardiovascular diseases. The other authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Mouse maintenance and experiments were reviewed and overseen by the institutional animal use and care committee of the local authorities (Regierung von Oberbayern, ROB, Germany) and performed in accordance with the procedures provided by the animal protection representative of CSD. Human thrombus tissue specimens were obtained as disposable material from vascular surgery procedures under ethics allowance LMU Munich 18-104 and TUM-MRI project # 2799\/10).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"N\/A.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"512"}}