{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:11:49Z","timestamp":1790755909601,"version":"4.1.0"},"reference-count":83,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,11,5]],"date-time":"2022-11-05T00:00:00Z","timestamp":1667606400000},"content-version":"vor","delay-in-days":4,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["JA 3192\/1-1"],"award-info":[{"award-number":["JA 3192\/1-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["496182670"],"award-info":[{"award-number":["496182670"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National University Medicine (NUM) network","award":["01KX2121"],"award-info":[{"award-number":["01KX2121"]}]},{"DOI":"10.13039\/501100004426","name":"Dr. Werner Jackst\u00e4dt-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004426","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Universit\u00e4tsklinikum Halle (Saale)"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell. Mol. Life Sci."],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The non-classical human leukocyte antigen (HLA)-G exerts immune-suppressive properties modulating both NK and T cell responses. While it is physiologically expressed at the maternal\u2013fetal interface and in immune-privileged organs, HLA-G expression is found in tumors and in virus-infected cells. So far, there exists little information about the role of HLA-G and its interplay with immune cells in biopsies, surgical specimen or autopsy tissues of lung, kidney and\/or heart muscle from SARS-CoV-2-infected patients compared to control tissues. Heterogeneous, but higher HLA-G protein expression levels were detected in lung alveolar epithelial cells of SARS-CoV-2-infected patients compared to lung epithelial cells from influenza-infected patients, but not in other organs or lung epithelia from non-viral-infected patients, which was not accompanied by high levels of SARS-CoV-2 nucleocapsid antigen and spike protein, but inversely correlated to the HLA-G-specific miRNA expression. High HLA-G expression levels not only in SARS-CoV-2-, but also in influenza-infected lung tissues were associated with a high frequency of tissue-infiltrating immune cells, but low numbers of CD8<jats:sup>+<\/jats:sup> cells and an altered expression of hyperactivation and exhaustion markers in the lung epithelia combined with changes in the spatial distribution of macrophages and T cells. Thus, our data provide evidence for an involvement of HLA-G and HLA-G-specific miRNAs in immune escape and as suitable therapeutic targets for the treatment of SARS-CoV-2 infections.<\/jats:p>","DOI":"10.1007\/s00018-022-04592-9","type":"journal-article","created":{"date-parts":[[2022,11,5]],"date-time":"2022-11-05T07:04:51Z","timestamp":1667631891000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Induction of pulmonary HLA-G expression by SARS-CoV-2 infection"],"prefix":"10.1007","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5544-4958","authenticated-orcid":false,"given":"Barbara","family":"Seliger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Jasinski-Bergner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Massa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Biehl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Bachmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny","family":"Jonigk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Eichhorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arndt","family":"Hartmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Wickenhauser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,5]]},"reference":[{"issue":"1","key":"4592_CR1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1006\/scbi.1998.0103","volume":"9","author":"N Rouas-Freiss","year":"1999","unstructured":"Rouas-Freiss N, Khalil-Daher I, Riteau B, Menier C, Paul P, Dausset J, Carosella ED (1999) The immunotolerance role of HLA-G. Semin Cancer Biol 9(1):3\u201312. https:\/\/doi.org\/10.1006\/scbi.1998.0103","journal-title":"Semin Cancer Biol"},{"issue":"11","key":"4592_CR2","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1002\/1878-0261.12119","volume":"11","author":"D Tronik-Le Roux","year":"2017","unstructured":"Tronik-Le Roux D, Renard J, Verine J, Renault V, Tubacher E, LeMaoult J, Rouas-Freiss N, Deleuze JF, Desgrandschamps F, Carosella ED (2017) Novel landscape of HLA-G isoforms expressed in clear cell renal cell carcinoma patients. Mol Oncol 11(11):1561\u20131578. https:\/\/doi.org\/10.1002\/1878-0261.12119","journal-title":"Mol Oncol"},{"key":"4592_CR3","doi-asserted-by":"publisher","first-page":"361","DOI":"10.3389\/fonc.2018.00361","volume":"8","author":"A Lin","year":"2018","unstructured":"Lin A, Zhang X, Zhang RL, Zhang JG, Zhou WJ, Yan WH (2018) Clinical significance of potential unidentified HLA-G isoforms without alpha1 domain but containing intron 4 in colorectal cancer patients. Front Oncol 8:361. https:\/\/doi.org\/10.3389\/fonc.2018.00361","journal-title":"Front Oncol"},{"issue":"1\u20132","key":"4592_CR4","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/s11010-013-1708-5","volume":"381","author":"R Rizzo","year":"2013","unstructured":"Rizzo R, Trentini A, Bortolotti D, Manfrinato MC, Rotola A, Castellazzi M, Melchiorri L, Di Luca D, Dallocchio F, Fainardi E, Bellini T (2013) Matrix metalloproteinase-2 (MMP-2) generates soluble HLA-G1 by cell surface proteolytic shedding. Mol Cell Biochem 381(1\u20132):243\u2013255. https:\/\/doi.org\/10.1007\/s11010-013-1708-5","journal-title":"Mol Cell Biochem"},{"key":"4592_CR5","doi-asserted-by":"publisher","first-page":"597468","DOI":"10.3389\/fonc.2020.597468","volume":"10","author":"L Liu","year":"2020","unstructured":"Liu L, Wang L, Zhao L, He C, Wang G (2020) The role of HLA-G in tumor escape: manipulating the phenotype and function of immune cells. Front Oncol 10:597468. https:\/\/doi.org\/10.3389\/fonc.2020.597468","journal-title":"Front Oncol"},{"key":"4592_CR6","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21124362","author":"GT Ho","year":"2020","unstructured":"Ho GT, Celik AA, Huyton T, Hiemisch W, Blasczyk R, Simper GS, Bade-Doeding C (2020) NKG2A\/CD94 is a new immune receptor for HLA-G and distinguishes amino acid differences in the HLA-G heavy chain. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms21124362","journal-title":"Int J Mol Sci"},{"key":"4592_CR7","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/bs.ai.2015.04.001","volume":"127","author":"ED Carosella","year":"2015","unstructured":"Carosella ED, Rouas-Freiss N, Tronik-Le Roux D, Moreau P, LeMaoult J (2015) HLA-G: an immune checkpoint molecule. Adv Immunol 127:33\u2013144. https:\/\/doi.org\/10.1016\/bs.ai.2015.04.001","journal-title":"Adv Immunol"},{"issue":"3","key":"4592_CR8","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1111\/tan.12427","volume":"84","author":"G Amodio","year":"2014","unstructured":"Amodio G, de Albuquerque RS, Gregori S (2014) New insights into HLA-G mediated tolerance. Tissue Antigens 84(3):255\u2013263. https:\/\/doi.org\/10.1111\/tan.12427","journal-title":"Tissue Antigens"},{"key":"4592_CR9","doi-asserted-by":"publisher","first-page":"592010","DOI":"10.3389\/fimmu.2020.592010","volume":"11","author":"X Xu","year":"2020","unstructured":"Xu X, Zhou Y, Wei H (2020) Roles of HLA-G in the maternal-fetal immune microenvironment. Front Immunol 11:592010. https:\/\/doi.org\/10.3389\/fimmu.2020.592010","journal-title":"Front Immunol"},{"issue":"9","key":"4592_CR10","doi-asserted-by":"publisher","first-page":"e1077","DOI":"10.1002\/cti2.1077","volume":"8","author":"A Lin","year":"2019","unstructured":"Lin A, Yan WH (2019) Intercellular transfer of HLA-G: its potential in cancer immunology. Clin Transl Immunol 8(9):e1077. https:\/\/doi.org\/10.1002\/cti2.1077","journal-title":"Clin Transl Immunol"},{"issue":"10","key":"4592_CR11","doi-asserted-by":"publisher","first-page":"2055","DOI":"10.1182\/blood-2012-03-416792","volume":"120","author":"R Brown","year":"2012","unstructured":"Brown R, Kabani K, Favaloro J, Yang S, Ho PJ, Gibson J, Fromm P, Suen H, Woodland N, Nassif N, Hart D, Joshua D (2012) CD86+ or HLA-G+ can be transferred via trogocytosis from myeloma cells to T cells and are associated with poor prognosis. Blood 120(10):2055\u20132063. https:\/\/doi.org\/10.1182\/blood-2012-03-416792","journal-title":"Blood"},{"key":"4592_CR12","doi-asserted-by":"publisher","first-page":"173","DOI":"10.3389\/fimmu.2016.00173","volume":"7","author":"V Rebmann","year":"2016","unstructured":"Rebmann V, Konig L, Nardi Fda S, Wagner B, Manvailer LF, Horn PA (2016) The potential of HLA-G-bearing extracellular vesicles as a future element in HLA-G immune biology. Front Immunol 7:173. https:\/\/doi.org\/10.3389\/fimmu.2016.00173","journal-title":"Front Immunol"},{"key":"4592_CR13","doi-asserted-by":"publisher","first-page":"734068","DOI":"10.1155\/2014\/734068","volume":"2014","author":"EC Castelli","year":"2014","unstructured":"Castelli EC, Veiga-Castelli LC, Yaghi L, Moreau P, Donadi EA (2014) Transcriptional and posttranscriptional regulations of the HLA-G gene. J Immunol Res 2014:734068. https:\/\/doi.org\/10.1155\/2014\/734068","journal-title":"J Immunol Res"},{"key":"4592_CR14","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21124307","author":"N Jorgensen","year":"2020","unstructured":"Jorgensen N, Sayed A, Jeppesen HB, Persson G, Weisdorf I, Funck T, Hviid TVF (2020) Characterization of HLA-G regulation and HLA expression in breast cancer and malignant melanoma cell lines upon IFN-gamma stimulation and inhibition of DNA methylation. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms21124307","journal-title":"Int J Mol Sci"},{"issue":"14","key":"4592_CR15","first-page":"4107","volume":"63","author":"J Bukur","year":"2003","unstructured":"Bukur J, Rebmann V, Grosse-Wilde H, Luboldt H, Ruebben H, Drexler I, Sutter G, Huber C, Seliger B (2003) Functional role of human leukocyte antigen-G up-regulation in renal cell carcinoma. Cancer Res 63(14):4107\u20134111","journal-title":"Cancer Res"},{"issue":"9B","key":"4592_CR16","doi-asserted-by":"publisher","first-page":"2973","DOI":"10.1111\/j.1582-4934.2009.00800.x","volume":"13","author":"P Moreau","year":"2009","unstructured":"Moreau P, Flajollet S, Carosella ED (2009) Non-classical transcriptional regulation of HLA-G: an update. J Cell Mol Med 13(9B):2973\u20132989. https:\/\/doi.org\/10.1111\/j.1582-4934.2009.00800.x","journal-title":"J Cell Mol Med"},{"key":"4592_CR17","doi-asserted-by":"publisher","first-page":"4587520","DOI":"10.1155\/2017\/4587520","volume":"2017","author":"M Garziera","year":"2017","unstructured":"Garziera M, Scarabel L, Toffoli G (2017) Hypoxic modulation of HLA-G expression through the metabolic sensor HIF-1 in human cancer cells. J Immunol Res 2017:4587520. https:\/\/doi.org\/10.1155\/2017\/4587520","journal-title":"J Immunol Res"},{"issue":"3","key":"4592_CR18","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1073\/pnas.0337539100","volume":"100","author":"P Moreau","year":"2003","unstructured":"Moreau P, Mouillot G, Rousseau P, Marcou C, Dausset J, Carosella ED (2003) HLA-G gene repression is reversed by demethylation. Proc Natl Acad Sci USA 100(3):1191\u20131196. https:\/\/doi.org\/10.1073\/pnas.0337539100","journal-title":"Proc Natl Acad Sci USA"},{"key":"4592_CR19","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.scr.2017.01.005","volume":"19","author":"A Verloes","year":"2017","unstructured":"Verloes A, Spits C, Vercammen M, Geens M, LeMaoult J, Sermon K, Coucke W, Van de Velde H (2017) The role of methylation, DNA polymorphisms and microRNAs on HLA-G expression in human embryonic stem cells. Stem Cell Res 19:118\u2013127. https:\/\/doi.org\/10.1016\/j.scr.2017.01.005","journal-title":"Stem Cell Res"},{"issue":"3","key":"4592_CR20","doi-asserted-by":"publisher","first-page":"e33395","DOI":"10.1371\/journal.pone.0033395","volume":"7","author":"I Manaster","year":"2012","unstructured":"Manaster I, Goldman-Wohl D, Greenfield C, Nachmani D, Tsukerman P, Hamani Y, Yagel S, Mandelboim O (2012) MiRNA-mediated control of HLA-G expression and function. PLoS ONE 7(3):e33395. https:\/\/doi.org\/10.1371\/journal.pone.0033395","journal-title":"PLoS ONE"},{"issue":"18","key":"4592_CR21","doi-asserted-by":"publisher","first-page":"26866","DOI":"10.18632\/oncotarget.8567","volume":"7","author":"S Jasinski-Bergner","year":"2016","unstructured":"Jasinski-Bergner S, Reches A, Stoehr C, Massa C, Gonschorek E, Huettelmaier S, Braun J, Wach S, Wullich B, Spath V, Wang E, Marincola FM, Mandelboim O, Hartmann A, Seliger B (2016) Identification of novel microRNAs regulating HLA-G expression and investigating their clinical relevance in renal cell carcinoma. Oncotarget 7(18):26866\u201326878. https:\/\/doi.org\/10.18632\/oncotarget.8567","journal-title":"Oncotarget"},{"issue":"6","key":"4592_CR22","doi-asserted-by":"publisher","first-page":"e1008805","DOI":"10.1080\/2162402X.2015.1008805","volume":"4","author":"S Jasinski-Bergner","year":"2015","unstructured":"Jasinski-Bergner S, Stoehr C, Bukur J, Massa C, Braun J, Huttelmaier S, Spath V, Wartenberg R, Legal W, Taubert H, Wach S, Wullich B, Hartmann A, Seliger B (2015) Clinical relevance of miR-mediated HLA-G regulation and the associated immune cell infiltration in renal cell carcinoma. Oncoimmunology 4(6):e1008805. https:\/\/doi.org\/10.1080\/2162402X.2015.1008805","journal-title":"Oncoimmunology"},{"key":"4592_CR23","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2019-000396","author":"M Friedrich","year":"2020","unstructured":"Friedrich M, Vaxevanis CK, Biehl K, Mueller A, Seliger B (2020) Targeting the coding sequence: opposing roles in regulating classical and non-classical MHC class I molecules by miR-16 and miR-744. J Immunother Cancer. https:\/\/doi.org\/10.1136\/jitc-2019-000396","journal-title":"J Immunother Cancer"},{"issue":"12","key":"4592_CR24","doi-asserted-by":"publisher","first-page":"4967","DOI":"10.4049\/jimmunol.1501550","volume":"196","author":"A Reches","year":"2016","unstructured":"Reches A, Nachmani D, Berhani O, Duev-Cohen A, Shreibman D, Ophir Y, Seliger B, Mandelboim O (2016) HNRNPR regulates the expression of classical and nonclassical MHC class I proteins. J Immunol 196(12):4967\u20134976. https:\/\/doi.org\/10.4049\/jimmunol.1501550","journal-title":"J Immunol"},{"issue":"3","key":"4592_CR25","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1016\/j.bbrc.2015.07.040","volume":"464","author":"B Song","year":"2015","unstructured":"Song B, Guan Z, Liu F, Sun D, Wang K, Qu H (2015) Long non-coding RNA HOTAIR promotes HLA-G expression via inhibiting miR-152 in gastric cancer cells. Biochem Biophys Res Commun 464(3):807\u2013813. https:\/\/doi.org\/10.1016\/j.bbrc.2015.07.040","journal-title":"Biochem Biophys Res Commun"},{"issue":"4","key":"4592_CR26","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.humimm.2007.01.010","volume":"68","author":"M Shih Ie","year":"2007","unstructured":"Shih Ie M (2007) Application of human leukocyte antigen-G expression in the diagnosis of human cancer. Hum Immunol 68(4):272\u2013276. https:\/\/doi.org\/10.1016\/j.humimm.2007.01.010","journal-title":"Hum Immunol"},{"issue":"3","key":"4592_CR27","first-page":"431","volume":"44","author":"C Torun Edis","year":"2010","unstructured":"Torun Edis C, Yagci Caglayik D, Uyar Y, Korukluoglu G, Ertek M (2010) Sandfly fever outbreak in a province at Central Anatolia, Turkey. Mikrobiyol Bul 44(3):431\u2013439","journal-title":"Mikrobiyol Bul"},{"issue":"12","key":"4592_CR28","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1016\/j.humimm.2014.09.019","volume":"75","author":"E Catamo","year":"2014","unstructured":"Catamo E, Zupin L, Crovella S, Celsi F, Segat L (2014) Non-classical MHC-I human leukocyte antigen (HLA-G) in hepatotropic viral infections and in hepatocellular carcinoma. Hum Immunol 75(12):1225\u20131231. https:\/\/doi.org\/10.1016\/j.humimm.2014.09.019","journal-title":"Hum Immunol"},{"key":"4592_CR29","doi-asserted-by":"publisher","first-page":"298569","DOI":"10.1155\/2014\/298569","volume":"2014","author":"L Amiot","year":"2014","unstructured":"Amiot L, Vu N, Samson M (2014) Immunomodulatory properties of HLA-G in infectious diseases. J Immunol Res 2014:298569. https:\/\/doi.org\/10.1155\/2014\/298569","journal-title":"J Immunol Res"},{"issue":"2","key":"4592_CR30","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1002\/ana.21705","volume":"66","author":"YH Huang","year":"2009","unstructured":"Huang YH, Zozulya AL, Weidenfeller C, Metz I, Buck D, Toyka KV, Bruck W, Wiendl H (2009) Specific central nervous system recruitment of HLA-G(+) regulatory T cells in multiple sclerosis. Ann Neurol 66(2):171\u2013183. https:\/\/doi.org\/10.1002\/ana.21705","journal-title":"Ann Neurol"},{"key":"4592_CR31","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/1465-9921-14-4","volume":"14","author":"SR White","year":"2013","unstructured":"White SR, Loisel DA, Stern R, Laxman B, Floreth T, Marroquin BA (2013) Human leukocyte antigen-G expression in differentiated human airway epithelial cells: lack of modulation by Th2-associated cytokines. Respir Res 14:4. https:\/\/doi.org\/10.1186\/1465-9921-14-4","journal-title":"Respir Res"},{"key":"4592_CR32","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.3389\/fimmu.2020.01349","volume":"11","author":"HH Xu","year":"2020","unstructured":"Xu HH, Yan WH, Lin A (2020) The role of HLA-G in human papillomavirus infections and cervical carcinogenesis. Front Immunol 11:1349. https:\/\/doi.org\/10.3389\/fimmu.2020.01349","journal-title":"Front Immunol"},{"issue":"8","key":"4592_CR33","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1177\/1933719110369183","volume":"17","author":"DD Dong","year":"2010","unstructured":"Dong DD, Yang H, Li K, Xu G, Song LH, Fan XL, Jiang XL, Yie SM (2010) Human leukocyte antigen-G (HLA-G) expression in cervical lesions: association with cancer progression, HPV 16\/18 infection, and host immune response. Reprod Sci 17(8):718\u2013723. https:\/\/doi.org\/10.1177\/1933719110369183","journal-title":"Reprod Sci"},{"issue":"1","key":"4592_CR34","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1111\/sji.12385","volume":"83","author":"DM Souza","year":"2016","unstructured":"Souza DM, Genre J, Silva TG, Soares CP, Rocha KB, Oliveira CN, Jatoba CA, Andrade JM, Moreau P, Medeiros Ada C, Donadi EA, Crispim JC (2016) Upregulation of soluble HLA-G5 and HLA-G6 isoforms in the milder histopathological stages of Helicobacter pylori infection: a role for subverting immune responses? Scand J Immunol 83(1):38\u201343. https:\/\/doi.org\/10.1111\/sji.12385","journal-title":"Scand J Immunol"},{"issue":"4","key":"4592_CR35","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1111\/tan.13196","volume":"91","author":"A Sabbagh","year":"2018","unstructured":"Sabbagh A, Sonon P, Sadissou I, Mendes-Junior CT, Garcia A, Donadi EA, Courtin D (2018) The role of HLA-G in parasitic diseases. HLA 91(4):255\u2013270. https:\/\/doi.org\/10.1111\/tan.13196","journal-title":"HLA"},{"issue":"1","key":"4592_CR36","doi-asserted-by":"publisher","first-page":"782","DOI":"10.2119\/molmed.2015.00083","volume":"21","author":"A Lin","year":"2015","unstructured":"Lin A, Yan WH (2015) Human leukocyte antigen-G (HLA-G) expression in cancers: roles in immune evasion, metastasis and target for therapy. Mol Med 21(1):782\u2013791. https:\/\/doi.org\/10.2119\/molmed.2015.00083","journal-title":"Mol Med"},{"issue":"8","key":"4592_CR37","doi-asserted-by":"publisher","first-page":"3057","DOI":"10.1111\/cas.14514","volume":"111","author":"N Hiraoka","year":"2020","unstructured":"Hiraoka N, Ino Y, Hori S, Yamazaki-Itoh R, Naito C, Shimasaki M, Esaki M, Nara S, Kishi Y, Shimada K, Nakamura N, Torigoe T, Heike Y (2020) Expression of classical human leukocyte antigen class I antigens, HLA-E and HLA-G, is adversely prognostic in pancreatic cancer patients. Cancer Sci 111(8):3057\u20133070. https:\/\/doi.org\/10.1111\/cas.14514","journal-title":"Cancer Sci"},{"key":"4592_CR38","doi-asserted-by":"publisher","first-page":"614773","DOI":"10.3389\/fimmu.2021.614773","volume":"12","author":"HH Xu","year":"2021","unstructured":"Xu HH, Gan J, Xu DP, Li L, Yan WH (2021) Comprehensive transcriptomic analysis reveals the role of the immune checkpoint HLA-G molecule in cancers. Front Immunol 12:614773. https:\/\/doi.org\/10.3389\/fimmu.2021.614773","journal-title":"Front Immunol"},{"issue":"1","key":"4592_CR39","doi-asserted-by":"publisher","first-page":"15750","DOI":"10.1038\/s41598-020-72837-3","volume":"10","author":"FM Wuerfel","year":"2020","unstructured":"Wuerfel FM, Huebner H, Haberle L, Gass P, Hein A, Jud SM, Hack CC, Wunderle M, Schulz-Wendtland R, Erber R, Hartmann A, Ekici AB, Beckmann MW, Fasching PA, Ruebner M (2020) HLA-G and HLA-F protein isoform expression in breast cancer patients receiving neoadjuvant treatment. Sci Rep 10(1):15750. https:\/\/doi.org\/10.1038\/s41598-020-72837-3","journal-title":"Sci Rep"},{"issue":"7","key":"4592_CR40","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1007\/s12094-019-02244-2","volume":"22","author":"AD Lazaro-Sanchez","year":"2020","unstructured":"Lazaro-Sanchez AD, Salces-Ortiz P, Velasquez LI, Orozco-Beltran D, Diaz-Fernandez N, Juarez-Marroqui A (2020) HLA-G as a new tumor biomarker: detection of soluble isoforms of HLA-G in the serum and saliva of patients with colorectal cancer. Clin Transl Oncol 22(7):1166\u20131171. https:\/\/doi.org\/10.1007\/s12094-019-02244-2","journal-title":"Clin Transl Oncol"},{"key":"4592_CR41","doi-asserted-by":"publisher","first-page":"3890306","DOI":"10.1155\/2016\/3890306","volume":"2016","author":"R Rizzo","year":"2016","unstructured":"Rizzo R, Gabrielli L, Bortolotti D, Gentili V, Piccirilli G, Chiereghin A, Pavia C, Bolzani S, Guerra B, Simonazzi G, Cervi F, Capretti MG, Fainardi E, Luca DD, Landini MP, Lazzarotto T (2016) Study of soluble HLA-G in congenital human cytomegalovirus infection. J Immunol Res 2016:3890306. https:\/\/doi.org\/10.1155\/2016\/3890306","journal-title":"J Immunol Res"},{"issue":"2","key":"4592_CR42","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1111\/j.1399-0039.2011.01814.x","volume":"79","author":"Y Park","year":"2012","unstructured":"Park Y, Park Y, Lim HS, Kim YS, Hong DJ, Kim HS (2012) Soluble human leukocyte antigen-G expression in hepatitis B virus infection and hepatocellular carcinoma. Tissue Antigens 79(2):97\u2013103. https:\/\/doi.org\/10.1111\/j.1399-0039.2011.01814.x","journal-title":"Tissue Antigens"},{"issue":"10","key":"4592_CR43","doi-asserted-by":"publisher","first-page":"e13585","DOI":"10.1111\/ijcp.13585","volume":"74","author":"BC Bertol","year":"2020","unstructured":"Bertol BC, de Araujo JNG, Sadissou IA, Sonon P, Dias FC, Bortolin RH, de Figueiredo-Feitosa NL, de Freitas LCC, de Miranda Henrique SR, de Tarrapp CC, Oliveira Ramos AD, de Luchessi J, Freitas LMZ, Maciel VN, Silbiger and E. A. Donadi, (2020) Plasma levels of soluble HLA-G and cytokines in papillary thyroid carcinoma before and after thyroidectomy. Int J Clin Pract 74(10):e13585. https:\/\/doi.org\/10.1111\/ijcp.13585","journal-title":"Int J Clin Pract"},{"key":"4592_CR44","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.molimm.2018.04.007","volume":"99","author":"H Ben Yahia","year":"2018","unstructured":"Ben Yahia H, Babay W, Bortolotti D, Boujelbene N, Laaribi AB, Zidi N, Kehila M, Chelbi H, Boudabous A, Mrad K, Mezlini A, Di Luca D, Ouzari HI, Rizzo R, Zidi I (2018) Increased plasmatic soluble HLA-G levels in endometrial cancer. Mol Immunol 99:82\u201386. https:\/\/doi.org\/10.1016\/j.molimm.2018.04.007","journal-title":"Mol Immunol"},{"issue":"1","key":"4592_CR45","doi-asserted-by":"publisher","first-page":"8773","DOI":"10.1038\/s41598-020-65424-z","volume":"10","author":"L Scarabel","year":"2020","unstructured":"Scarabel L, Garziera M, Fortuna S, Asaro F, Toffoli G, Geremia S (2020) Soluble HLA-G expression levels and HLA-G\/irinotecan association in metastatic colorectal cancer treated with irinotecan-based strategy. Sci Rep 10(1):8773. https:\/\/doi.org\/10.1038\/s41598-020-65424-z","journal-title":"Sci Rep"},{"issue":"9","key":"4592_CR46","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1016\/j.humimm.2016.01.002","volume":"77","author":"L Konig","year":"2016","unstructured":"Konig L, Kasimir-Bauer S, Hoffmann O, Bittner AK, Wagner B, Manvailer LF, Schramm S, Bankfalvi A, Giebel B, Kimmig R, Horn PA, Rebmann V (2016) The prognostic impact of soluble and vesicular HLA-G and its relationship to circulating tumor cells in neoadjuvant treated breast cancer patients. Hum Immunol 77(9):791\u2013799. https:\/\/doi.org\/10.1016\/j.humimm.2016.01.002","journal-title":"Hum Immunol"},{"issue":"2","key":"4592_CR47","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1111\/tan.12359","volume":"84","author":"HH Xu","year":"2014","unstructured":"Xu HH, Shi WW, Lin A, Yan WH (2014) HLA-G 3\u2019 untranslated region polymorphisms influence the susceptibility for human papillomavirus infection. Tissue Antigens 84(2):216\u2013222. https:\/\/doi.org\/10.1111\/tan.12359","journal-title":"Tissue Antigens"},{"issue":"10224","key":"4592_CR48","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/S0140-6736(20)30251-8","volume":"395","author":"R Lu","year":"2020","unstructured":"Lu R, Zhao X, Li J, Niu P, Yang B, Wu H, Wang W, Song H, Huang B, Zhu N, Bi Y, Ma X, Zhan F, Wang L, Hu T, Zhou H, Hu Z, Zhou W, Zhao L, Chen J, Meng Y, Wang J, Lin Y, Yuan J, Xie Z, Ma J, Liu WJ, Wang D, Xu W, Holmes EC, Gao GF, Wu G, Chen W, Shi W, Tan W (2020) Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet 395(10224):565\u2013574. https:\/\/doi.org\/10.1016\/S0140-6736(20)30251-8","journal-title":"Lancet"},{"issue":"11","key":"4592_CR49","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1001\/jama.2020.1585","volume":"323","author":"D Wang","year":"2020","unstructured":"Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, Wang B, Xiang H, Cheng Z, Xiong Y, Zhao Y, Li Y, Wang X, Peng Z (2020) Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA 323(11):1061\u20131069. https:\/\/doi.org\/10.1001\/jama.2020.1585","journal-title":"JAMA"},{"issue":"5","key":"4592_CR50","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1016\/j.cell.2020.04.035","volume":"181","author":"CGK Ziegler","year":"2020","unstructured":"Ziegler CGK, Allon SJ, Nyquist SK, Mbano IM, Miao VN, Tzouanas CN, Cao Y, Yousif AS, Bals J, Hauser BM, Feldman J, Muus C, Wadsworth MH, Kazer SW, Hughes TK, Doran B, Gatter GJ, Vukovic M, Taliaferro F, Mead BE, Guo Z, Wang JP, Gras D, Plaisant M, Ansari M, Angelidis I, Adler H, Sucre JMS, Taylor CJ, Lin B, Waghray A, Mitsialis V, Dwyer DF, Buchheit KM, Boyce JA, Barrett NA, Laidlaw TM, Carroll SL, Colonna L, Tkachev V, Peterson CW, Yu A, Zheng HB, Gideon HP, Winchell CG, Lin PL, Bingle CD, Snapper SB, Kropski JA, Theis FJ, Schiller HB, Zaragosi LE, Barbry P, Leslie A, Kiem HP, Flynn JL, Fortune SM, Berger B, Finberg RW, Kean LS, Garber M, Schmidt AG, Lingwood D, Shalek AK, Ordovas-Montanes J, H. C. A. L. B. N. E. a. lung-network@humancellatlas.org and H. C. A. L. B. Network (2020) SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues. Cell 181(5):1016\u20131035. https:\/\/doi.org\/10.1016\/j.cell.2020.04.035","journal-title":"Cell"},{"issue":"7821","key":"4592_CR51","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/s41586-020-2588-y","volume":"584","author":"C Lucas","year":"2020","unstructured":"Lucas C, Wong P, Klein J, Castro TBR, Silva J, Sundaram M, Ellingson MK, Mao T, Oh JE, Israelow B, Takahashi T, Tokuyama M, Lu P, Venkataraman A, Park A, Mohanty S, Wang H, Wyllie AL, Vogels CBF, Earnest R, Lapidus S, Ott IM, Moore AJ, Muenker MC, Fournier JB, Campbell M, Odio CD, Casanovas-Massana A, Yale IT, Herbst R, Shaw AC, Medzhitov R, Schulz WL, Grubaugh ND, Dela Cruz C, Farhadian S, Ko AI, Omer SB, Iwasaki A (2020) Longitudinal analyses reveal immunological misfiring in severe COVID-19. Nature 584(7821):463\u2013469. https:\/\/doi.org\/10.1038\/s41586-020-2588-y","journal-title":"Nature"},{"key":"4592_CR52","doi-asserted-by":"publisher","DOI":"10.1101\/2021.03.08.434433","author":"J Park","year":"2021","unstructured":"Park J, Foox J, Hether T, Danko D, Warren S, Kim Y, Reeves J, Butler DJ, Mozsary C, Rosiene J, Shaiber A, Afshinnekoo E, MacKay M, Bram Y, Chandar V, Geiger H, Craney A, Velu P, Melnick AM, Hajirasouliha I, Beheshti A, Taylor D, Saravia-Butler A, Singh U, Wurtele ES, Schisler J, Fennessey S, Corvelo A, Zody MC, Germer S, Salvatore S, Levy S, Wu S, Tatonetti N, Shapira S, Salvatore M, Loda M, Westblade LF, Cushing M, Rennert H, Kriegel AJ, Elemento O, Imielinski M, Borczuk AC, Meydan C, Schwartz RE, Mason CE (2021) Systemic tissue and cellular disruption from SARS-CoV-2 infection revealed in COVID-19 autopsies and spatial omics tissue maps. bioRxiv. https:\/\/doi.org\/10.1101\/2021.03.08.434433","journal-title":"bioRxiv"},{"key":"4592_CR53","doi-asserted-by":"publisher","DOI":"10.1172\/JCI145853","author":"RM Rebillard","year":"2021","unstructured":"Rebillard RM, Charabati M, Grasmuck C, Filali-Mouhim A, Tastet O, Brassard N, Daigneault A, Bourbonniere L, Anand SP, Balthazard R, Beaudoin-Bussieres G, Gasser R, Benlarbi M, Moratalla AC, Solorio YC, Boutin M, Farzam-Kia N, Descoteaux-Dinelle J, Fournier AP, Gowing E, Laumaea A, Jamann H, Lahav B, Goyette G, Lemaitre F, Mamane VH, Prevost J, Richard J, Thai K, Cailhier JF, Chomont N, Finzi A, Chasse M, Durand M, Arbour N, Kaufmann DE, Prat A, Larochelle C (2021) Identification of SARS-CoV-2-specific immune alterations in acutely ill patients. J Clin Invest. https:\/\/doi.org\/10.1172\/JCI145853","journal-title":"J Clin Invest"},{"issue":"3","key":"4592_CR54","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1038\/s41423-020-00557-9","volume":"18","author":"S Varchetta","year":"2021","unstructured":"Varchetta S, Mele D, Oliviero B, Mantovani S, Ludovisi S, Cerino A, Bruno R, Castelli A, Mosconi M, Vecchia M, Roda S, Sachs M, Klersy C, Mondelli MU (2021) Unique immunological profile in patients with COVID-19. Cell Mol Immunol 18(3):604\u2013612. https:\/\/doi.org\/10.1038\/s41423-020-00557-9","journal-title":"Cell Mol Immunol"},{"issue":"6","key":"4592_CR55","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1080\/1744666X.2022.2074403","volume":"18","author":"R Ameratunga","year":"2022","unstructured":"Ameratunga R, Woon ST, Steele R, Lehnert K, Leung E, Brooks AES (2022) Severe COVID-19 is a T cell immune dysregulatory disorder triggered by SARS-CoV-2. Expert Rev Clin Immunol 18(6):557\u2013565. https:\/\/doi.org\/10.1080\/1744666X.2022.2074403","journal-title":"Expert Rev Clin Immunol"},{"issue":"2","key":"4592_CR56","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1080\/08820139.2020.1825480","volume":"51","author":"P Lotfinejad","year":"2022","unstructured":"Lotfinejad P, Asadzadeh Z, Najjary S, Somi MH, Hajiasgharzadeh K, Mokhtarzadeh A, Derakhshani A, Roshani E, Baradaran B (2022) COVID-19 infection: concise review based on the immunological perspective. Immunol Invest 51(2):246\u2013265. https:\/\/doi.org\/10.1080\/08820139.2020.1825480","journal-title":"Immunol Invest"},{"issue":"5","key":"4592_CR57","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1093\/intimm\/11.5.803","volume":"11","author":"P Moreau","year":"1999","unstructured":"Moreau P, Adrian-Cabestre F, Menier C, Guiard V, Gourand L, Dausset J, Carosella ED, Paul P (1999) IL-10 selectively induces HLA-G expression in human trophoblasts and monocytes. Int Immunol 11(5):803\u2013811. https:\/\/doi.org\/10.1093\/intimm\/11.5.803","journal-title":"Int Immunol"},{"key":"4592_CR58","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23179736","author":"JFC Cordeiro","year":"2022","unstructured":"Cordeiro JFC, Fernandes TM, Toro DM, da Silva-Neto PV, Pimentel VE, Perez MM, de Carvalho JCS, Fraga-Silva TFC, Oliveira CNS, Argolo JGM, Degiovani AM, Ostini FM, Puginna EF, da Silva JS, Santos I, Bonato VLD, Cardoso CRB, Dias-Baruffi M, Faccioli LH, Donadi EA, Sorgi CA, Fernandes APM, G. On Behalf Of The Immunocovid Study (2022) The severity of COVID-19 affects the plasma soluble levels of the immune checkpoint HLA-G molecule. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms23179736","journal-title":"Int J Mol Sci"},{"issue":"5","key":"4592_CR59","doi-asserted-by":"publisher","first-page":"e1128","DOI":"10.1002\/cti2.1128","volume":"9","author":"S Zhang","year":"2020","unstructured":"Zhang S, Gan J, Chen BG, Zheng D, Zhang JG, Lin RH, Zhou YP, Yang WY, Lin A, Yan WH (2020) Dynamics of peripheral immune cells and their HLA-G and receptor expressions in a patient suffering from critical COVID-19 pneumonia to convalescence. Clin Transl Immunol 9(5):e1128. https:\/\/doi.org\/10.1002\/cti2.1128","journal-title":"Clin Transl Immunol"},{"key":"4592_CR60","doi-asserted-by":"publisher","first-page":"599736","DOI":"10.3389\/fimmu.2020.599736","volume":"11","author":"TFC Fraga-Silva","year":"2020","unstructured":"Fraga-Silva TFC, Maruyama SR, Sorgi CA, Russo EMS, Fernandes APM, de Barros Cardoso CR, Faccioli LH, Dias-Baruffi M, Bonato VLD (2020) COVID-19: integrating the complexity of systemic and pulmonary immunopathology to identify biomarkers for different outcomes. Front Immunol 11:599736. https:\/\/doi.org\/10.3389\/fimmu.2020.599736","journal-title":"Front Immunol"},{"issue":"10","key":"4592_CR61","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1016\/j.humimm.2021.07.007","volume":"82","author":"NT Al-Bayatee","year":"2021","unstructured":"Al-Bayatee NT, Ad\u2019hiah AH (2021) Soluble HLA-G is upregulated in serum of patients with severe COVID-19. Hum Immunol 82(10):726\u2013732. https:\/\/doi.org\/10.1016\/j.humimm.2021.07.007","journal-title":"Hum Immunol"},{"issue":"4","key":"4592_CR62","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1136\/jcp.41.4.467","volume":"41","author":"T Ashcroft","year":"1988","unstructured":"Ashcroft T, Simpson JM, Timbrell V (1988) Simple method of estimating severity of pulmonary fibrosis on a numerical scale. J Clin Pathol 41(4):467\u2013470. https:\/\/doi.org\/10.1136\/jcp.41.4.467","journal-title":"J Clin Pathol"},{"issue":"1","key":"4592_CR63","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1093\/ajcp\/aqab087","volume":"157","author":"D Gagiannis","year":"2022","unstructured":"Gagiannis D, Umathum VG, Bloch W, Rother C, Stahl M, Witte HM, Djudjaj S, Boor P, Steinestel K (2022) Antemortem vs postmortem histopathologic and ultrastructural findings in paired transbronchial biopsy specimens and lung autopsy samples from three patients with confirmed SARS-CoV-2. Am J Clin Pathol 157(1):54\u201363. https:\/\/doi.org\/10.1093\/ajcp\/aqab087","journal-title":"Am J Clin Pathol"},{"issue":"2","key":"4592_CR64","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1093\/annonc\/mdu450","volume":"26","author":"R Salgado","year":"2015","unstructured":"Salgado R, Denkert C, Demaria S, Sirtaine N, Klauschen F, Pruneri G, Wienert S, Van den Eynden G, Baehner FL, Penault-Llorca F, Perez EA, Thompson EA, Symmans WF, Richardson AL, Brock J, Criscitiello C, Bailey H, Ignatiadis M, Floris G, Sparano J, Kos Z, Nielsen T, Rimm DL, Allison KH, Reis-Filho JS, Loibl S, Sotiriou C, Viale G, Badve S, Adams S, Willard-Gallo K, Loi S, T. W. G. International (2015) The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: recommendations by an International TILs Working Group 2014. Ann Oncol 26(2):259\u2013271. https:\/\/doi.org\/10.1093\/annonc\/mdu450","journal-title":"Ann Oncol"},{"issue":"20","key":"4592_CR65","doi-asserted-by":"publisher","first-page":"3798","DOI":"10.1200\/JCO.2003.11.069","volume":"21","author":"FR Hirsch","year":"2003","unstructured":"Hirsch FR, Varella-Garcia M, Bunn PA Jr, Di Maria MV, Veve R, Bremmes RM, Baron AE, Zeng C, Franklin WA (2003) Epidermal growth factor receptor in non-small-cell lung carcinomas: correlation between gene copy number and protein expression and impact on prognosis. J Clin Oncol 21(20):3798\u20133807. https:\/\/doi.org\/10.1200\/JCO.2003.11.069","journal-title":"J Clin Oncol"},{"key":"4592_CR66","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/978-1-4939-8979-9_2","volume":"1913","author":"C Wickenhauser","year":"2019","unstructured":"Wickenhauser C, Bethmann D, Feng Z, Jensen SM, Ballesteros-Merino C, Massa C, Steven A, Bauer M, Kaatzsch P, Pazaitis N, Toma G, Bifulco CB, Fox BA, Seliger B (2019) Multispectral fluorescence imaging allows for distinctive topographic assessment and subclassification of tumor-infiltrating and surrounding immune cells. Methods Mol Biol 1913:13\u201331. https:\/\/doi.org\/10.1007\/978-1-4939-8979-9_2","journal-title":"Methods Mol Biol"},{"issue":"20","key":"4592_CR67","doi-asserted-by":"publisher","first-page":"e179","DOI":"10.1093\/nar\/gni178","volume":"33","author":"C Chen","year":"2005","unstructured":"Chen C, Ridzon DA, Broomer AJ, Zhou Z, Lee DH, Nguyen JT, Barbisin M, Xu NL, Mahuvakar VR, Andersen MR, Lao KQ, Livak KJ, Guegler KJ (2005) Real-time quantification of microRNAs by stem-loop RT-PCR. Nucleic Acids Res 33(20):e179. https:\/\/doi.org\/10.1093\/nar\/gni178","journal-title":"Nucleic Acids Res"},{"key":"4592_CR68","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21030900","author":"A Reches","year":"2020","unstructured":"Reches A, Berhani O, Mandelboim O (2020) A unique regulation region in the 3\u2019 UTR of HLA-G with a promising potential. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms21030900","journal-title":"Int J Mol Sci"},{"key":"4592_CR69","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1146\/annurev-immunol-041015-055318","volume":"37","author":"LM McLane","year":"2019","unstructured":"McLane LM, Abdel-Hakeem MS, Wherry EJ (2019) CD8 T cell exhaustion during chronic viral infection and cancer. Annu Rev Immunol 37:457\u2013495. https:\/\/doi.org\/10.1146\/annurev-immunol-041015-055318","journal-title":"Annu Rev Immunol"},{"key":"4592_CR70","doi-asserted-by":"publisher","first-page":"104580","DOI":"10.1016\/j.meegid.2020.104580","volume":"85","author":"S Rashidi","year":"2020","unstructured":"Rashidi S, Farhadi L, Ghasemi F, Sheikhesmaeili F, Mohammadi A (2020) The potential role of HLA-G in the pathogenesis of HBV infection: Immunosuppressive or immunoprotective? Infect Genet Evol 85:104580. https:\/\/doi.org\/10.1016\/j.meegid.2020.104580","journal-title":"Infect Genet Evol"},{"issue":"1","key":"4592_CR71","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1006\/scbi.1998.0106","volume":"9","author":"DJ Schust","year":"1999","unstructured":"Schust DJ, Tortorella D, Ploegh HL (1999) HLA-G and HLA-C at the feto-maternal interface: lessons learned from pathogenic viruses. Semin Cancer Biol 9(1):37\u201346. https:\/\/doi.org\/10.1006\/scbi.1998.0106","journal-title":"Semin Cancer Biol"},{"key":"4592_CR72","doi-asserted-by":"publisher","first-page":"593595","DOI":"10.3389\/fimmu.2021.593595","volume":"12","author":"JA Choreno-Parra","year":"2021","unstructured":"Choreno-Parra JA, Jimenez-Alvarez LA, Cruz-Lagunas A, Rodriguez-Reyna TS, Ramirez-Martinez G, Sandoval-Vega M, Hernandez-Garcia DL, Choreno-Parra EM, Balderas-Martinez YI, Martinez-Sanchez ME, Marquez-Garcia E, Sciutto E, Moreno-Rodriguez J, Barreto-Rodriguez JO, Vazquez-Rojas H, Centeno-Saenz GI, Alvarado-Pena N, Salinas-Lara C, Sanchez-Garibay C, Galeana-Cadena D, Hernandez G, Mendoza-Milla C, Dominguez A, Granados J, Mena-Hernandez L, Perez-Buenfil LA, Dominguez-Cheritt G, Cabello-Gutierrez C, Luna-Rivero C, Salas-Hernandez J, Santillan-Doherty P, Regalado J, Hernandez-Martinez A, Orozco L, Avila-Moreno F, Garcia-Latorre EA, Hernandez-Cardenas CM, Khader SA, Zlotnik A, Zuniga J (2021) Clinical and immunological factors that distinguish COVID-19 from pandemic influenza A(H1N1). Front Immunol 12:593595. https:\/\/doi.org\/10.3389\/fimmu.2021.593595","journal-title":"Front Immunol"},{"key":"4592_CR73","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.69661","author":"AR Schuurman","year":"2021","unstructured":"Schuurman AR, Reijnders TDY, Saris A, Ramirez Moral I, Schinkel M, de Brabander J, van Linge C, Vermeulen L, Scicluna BP, Wiersinga WJ, Vieira Braga FA, van der Poll T (2021) Integrated single-cell analysis unveils diverging immune features of COVID-19, influenza, and other community-acquired pneumonia. Elife. https:\/\/doi.org\/10.7554\/eLife.69661","journal-title":"Elife"},{"issue":"6","key":"4592_CR74","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1016\/j.cell.2020.08.001","volume":"182","author":"J Schulte-Schrepping","year":"2020","unstructured":"Schulte-Schrepping J, Reusch N, Paclik D, Bassler K, Schlickeiser S, Zhang B, Kramer B, Krammer T, Brumhard S, Bonaguro L, De Domenico E, Wendisch D, Grasshoff M, Kapellos TS, Beckstette M, Pecht T, Saglam A, Dietrich O, Mei HE, Schulz AR, Conrad C, Kunkel D, Vafadarnejad E, Xu CJ, Horne A, Herbert M, Drews A, Thibeault C, Pfeiffer M, Hippenstiel S, Hocke A, Muller-Redetzky H, Heim KM, Machleidt F, Uhrig A, Bosquillon de Jarcy L, Jurgens L, Stegemann M, Glosenkamp CR, Volk HD, Goffinet C, Landthaler M, Wyler E, Georg P, Schneider M, Dang-Heine C, Neuwinger N, Kappert K, Tauber R, Corman V, Raabe J, Kaiser KM, Vinh MT, Rieke G, Meisel C, Ulas T, Becker M, Geffers R, Witzenrath M, Drosten C, Suttorp N, von Kalle C, Kurth F, Handler K, Schultze JL, Aschenbrenner AC, Li Y, Nattermann J, Sawitzki B, Saliba AE, Sander LE, Deutsche C-OI (2020) Severe COVID-19 is marked by a dysregulated myeloid cell compartment. Cell 182(6):1419\u20131440. https:\/\/doi.org\/10.1016\/j.cell.2020.08.001","journal-title":"Cell"},{"key":"4592_CR75","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1186\/s12929-015-0177-4","volume":"22","author":"Z Guan","year":"2015","unstructured":"Guan Z, Song B, Liu F, Sun D, Wang K, Qu H (2015) TGF-beta induces HLA-G expression through inhibiting miR-152 in gastric cancer cells. J Biomed Sci 22:107. https:\/\/doi.org\/10.1186\/s12929-015-0177-4","journal-title":"J Biomed Sci"},{"issue":"2","key":"4592_CR76","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/j.ajpath.2012.10.021","volume":"182","author":"IJ Wastowski","year":"2013","unstructured":"Wastowski IJ, Simoes RT, Yaghi L, Donadi EA, Pancoto JT, Poras I, Lechapt-Zalcman E, Bernaudin M, Valable S, Carlotti CG Jr, Flajollet S, Jensen SS, Ferrone S, Carosella ED, Kristensen BW, Moreau P (2013) Human leukocyte antigen-G is frequently expressed in glioblastoma and may be induced in vitro by combined 5-aza-2\u2019-deoxycytidine and interferon-gamma treatments: results from a multicentric study. Am J Pathol 182(2):540\u2013552. https:\/\/doi.org\/10.1016\/j.ajpath.2012.10.021","journal-title":"Am J Pathol"},{"issue":"44","key":"4592_CR77","doi-asserted-by":"publisher","first-page":"16412","DOI":"10.1073\/pnas.0605228103","volume":"103","author":"M Shiroishi","year":"2006","unstructured":"Shiroishi M, Kuroki K, Rasubala L, Tsumoto K, Kumagai I, Kurimoto E, Kato K, Kohda D, Maenaka K (2006) Structural basis for recognition of the nonclassical MHC molecule HLA-G by the leukocyte Ig-like receptor B2 (LILRB2\/LIR2\/ILT4\/CD85d). Proc Natl Acad Sci USA 103(44):16412\u201316417. https:\/\/doi.org\/10.1073\/pnas.0605228103","journal-title":"Proc Natl Acad Sci USA"},{"issue":"69","key":"4592_CR78","doi-asserted-by":"publisher","first-page":"33160","DOI":"10.18632\/oncotarget.26036","volume":"9","author":"F Desgrandchamps","year":"2018","unstructured":"Desgrandchamps F, LeMaoult J, Goujon A, Riviere A, Rivero-Juarez A, Djouadou M, de Gouvello A, Dumont C, Wu CL, Culine S, Verine J, Rouas-Freiss N, Hennequin C, Masson-Lecomte A, Carosella ED (2018) Prediction of non-muscle-invasive bladder cancer recurrence by measurement of checkpoint HLAG\u2019s receptor ILT2 on peripheral CD8(+) T cells. Oncotarget 9(69):33160\u201333169. https:\/\/doi.org\/10.18632\/oncotarget.26036","journal-title":"Oncotarget"},{"issue":"1","key":"4592_CR79","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.immuni.2020.12.002","volume":"54","author":"MS Rha","year":"2021","unstructured":"Rha MS, Jeong HW, Ko JH, Choi SJ, Seo IH, Lee JS, Sa M, Kim AR, Joo EJ, Ahn JY, Kim JH, Song KH, Kim ES, Oh DH, Ahn MY, Choi HK, Jeon JH, Choi JP, Kim HB, Kim YK, Park SH, Choi WS, Choi JY, Peck KR, Shin EC (2021) PD-1-expressing SARS-CoV-2-Specific CD8(+) T cells are not exhausted, but functional in patients with COVID-19. Immunity 54(1):44\u201352. https:\/\/doi.org\/10.1016\/j.immuni.2020.12.002","journal-title":"Immunity"},{"key":"4592_CR80","doi-asserted-by":"publisher","first-page":"119124","DOI":"10.1016\/j.lfs.2021.119124","volume":"270","author":"PS Aghbash","year":"2021","unstructured":"Aghbash PS, Eslami N, Shamekh A, Entezari-Maleki T, Baghi HB (2021) SARS-CoV-2 infection: the role of PD-1\/PD-L1 and CTLA-4 axis. Life Sci 270:119124. https:\/\/doi.org\/10.1016\/j.lfs.2021.119124","journal-title":"Life Sci"},{"issue":"4","key":"4592_CR81","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1038\/s41590-022-01152-y","volume":"23","author":"TS Sumida","year":"2022","unstructured":"Sumida TS, Dulberg S, Schupp JC, Lincoln MR, Stillwell HA, Axisa PP, Comi M, Unterman A, Kaminski N, Madi A, Kuchroo VK, Hafler DA (2022) Type I interferon transcriptional network regulates expression of coinhibitory receptors in human T cells. Nat Immunol 23(4):632\u2013642. https:\/\/doi.org\/10.1038\/s41590-022-01152-y","journal-title":"Nat Immunol"},{"issue":"7848","key":"4592_CR82","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/s41586-020-03065-y","volume":"591","author":"E Pairo-Castineira","year":"2021","unstructured":"Pairo-Castineira E, Clohisey S, Klaric L, Bretherick AD, Rawlik K, Pasko D, Walker S, Parkinson N, Fourman MH, Russell CD, Furniss J, Richmond A, Gountouna E, Wrobel N, Harrison D, Wang B, Wu Y, Meynert A, Griffiths F, Oosthuyzen W, Kousathanas A, Moutsianas L, Yang Z, Zhai R, Zheng C, Grimes G, Beale R, Millar J, Shih B, Keating S, Zechner M, Haley C, Porteous DJ, Hayward C, Yang J, Knight J, Summers C, Shankar-Hari M, Klenerman P, Turtle L, Ho A, Moore SC, Hinds C, Horby P, Nichol A, Maslove D, Ling L, McAuley D, Montgomery H, Walsh T, Pereira AC, Renieri A, Gen OI, Gen CI, Shen X, Ponting CP, Fawkes A, Tenesa A, Caulfield M, Scott R, Rowan K, Murphy L, Openshaw PJM, Semple MG, Law A, Vitart V, Wilson JF, Baillie JK, I. C. Investigators, C.-H. G. Initiative, I. andMe, B. Investigators (2021) Genetic mechanisms of critical illness in COVID-19. Nature 591(7848):92\u201398. https:\/\/doi.org\/10.1038\/s41586-020-03065-y","journal-title":"Nature"},{"issue":"3","key":"4592_CR83","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1007\/s00403-021-02218-x","volume":"314","author":"AT Westin","year":"2022","unstructured":"Westin AT, Gardinassi LG, Soares EG, Da Silva JS, Donadi EA, Da Silva Souza C (2022) HLA-G, cytokines, and cytokine receptors in the non-aggressive basal cell carcinoma microenvironment. Arch Dermatol Res 314(3):247\u2013256. https:\/\/doi.org\/10.1007\/s00403-021-02218-x","journal-title":"Arch Dermatol Res"}],"container-title":["Cellular and Molecular Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-022-04592-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00018-022-04592-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-022-04592-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T11:17:32Z","timestamp":1669720652000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00018-022-04592-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":83,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["4592"],"URL":"https:\/\/doi.org\/10.1007\/s00018-022-04592-9","relation":{},"ISSN":["1420-682X","1420-9071"],"issn-type":[{"value":"1420-682X","type":"print"},{"value":"1420-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"19 July 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 October 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 October 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 November 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have declared that they have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was performed with the principles of the declaration of Helsinki. Approval was granted by the Ethics Committee of the Medical Faculty of the Martin Luther University of Halle-Wittenberg, Halle, Germany.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}],"article-number":"582"}}