{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T01:14:36Z","timestamp":1794273276941,"version":"4.9.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2023,3,18]],"date-time":"2023-03-18T00:00:00Z","timestamp":1679097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,3,18]],"date-time":"2023-03-18T00:00:00Z","timestamp":1679097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873178"],"award-info":[{"award-number":["81873178"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81904036"],"award-info":[{"award-number":["81904036"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The leading talent Training Program of Pudong Health Burea of Shanghai","award":["PWRl2019-03"],"award-info":[{"award-number":["PWRl2019-03"]}]},{"name":"Excellent subject leader training project of the three-year action plan of Shanghai public health system","award":["GWV-10.2-XD15"],"award-info":[{"award-number":["GWV-10.2-XD15"]}]},{"name":"Key discipline construction project of the three-year action plan of Shanghai public health system","award":["GWV-10.1-XK9"],"award-info":[{"award-number":["GWV-10.1-XK9"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell. Mol. Life Sci."],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1007\/s00018-023-04741-8","type":"journal-article","created":{"date-parts":[[2023,3,18]],"date-time":"2023-03-18T04:02:41Z","timestamp":1679112161000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["lncRNA miR4458HG modulates hepatocellular carcinoma progression by activating m6A-dependent glycolysis and promoting the polarization of tumor-associated macrophages"],"prefix":"10.1007","volume":"80","author":[{"given":"Ying","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menghan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongchao","family":"Mai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Borong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juhua","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4171-5008","authenticated-orcid":false,"given":"Wei","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,3,18]]},"reference":[{"issue":"11","key":"4741_CR1","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1038\/nrgastro.2014.157","volume":"11","author":"GJ Gores","year":"2014","unstructured":"Gores GJ (2014) Decade in review-hepatocellular carcinoma: HCC-subtypes, stratification and sorafenib. Nat Rev Gastroenterol Hepatol 11(11):645\u2013647","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"5","key":"4741_CR2","doi-asserted-by":"publisher","first-page":"2072","DOI":"10.1002\/hep.26130","volume":"57","author":"X Wang","year":"2013","unstructured":"Wang X, Zhang A, Sun H (2013) Power of metabolomics in diagnosis and biomarker discovery of hepatocellular carcinoma. Hepatology 57(5):2072\u20132077","journal-title":"Hepatology"},{"key":"4741_CR3","doi-asserted-by":"publisher","first-page":"77","DOI":"10.2147\/JHC.S224471","volume":"7","author":"AW Moawad","year":"2020","unstructured":"Moawad AW, Szklaruk J, Lall C et al (2020) Angiogenesis in hepatocellular carcinoma; pathophysiology, targeted therapy, and role of imaging. J Hepatocell Carcinoma 7:77\u201389","journal-title":"J Hepatocell Carcinoma"},{"issue":"5","key":"4741_CR4","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1038\/nrc3038","volume":"11","author":"WH Koppenol","year":"2011","unstructured":"Koppenol WH, Bounds PL, Dang CV (2011) Otto Warburg\u2019s contributions to current concepts of cancer metabolism. Nat Rev Cancer 11(5):325\u2013337","journal-title":"Nat Rev Cancer"},{"issue":"5","key":"4741_CR5","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1016\/j.cell.2008.08.021","volume":"134","author":"PP Hsu","year":"2008","unstructured":"Hsu PP, Sabatini DM (2008) Cancer cell metabolism: Warburg and beyond. Cell 134(5):703\u2013707","journal-title":"Cell"},{"issue":"4","key":"4741_CR6","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1002\/hep.30923","volume":"71","author":"TL Wong","year":"2020","unstructured":"Wong TL, Ng KY, Tan KV et al (2020) CRAF methylation by PRMT6 regulates aerobic glycolysis-driven hepatocarcinogenesis via ERK-dependent PKM2 nuclear relocalization and activation. Hepatology 71(4):1279\u20131296","journal-title":"Hepatology"},{"issue":"2","key":"4741_CR7","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1002\/hep.31280","volume":"73","author":"Q Zuo","year":"2021","unstructured":"Zuo Q, He J, Zhang S et al (2021) PPARgamma coactivator-1alpha suppresses metastasis of hepatocellular carcinoma by inhibiting Warburg effect by PPARgamma-dependent WNT\/beta-catenin\/pyruvate dehydrogenase kinase isozyme 1 axis. Hepatology 73(2):644\u2013660","journal-title":"Hepatology"},{"issue":"7485","key":"4741_CR8","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1038\/nature12943","volume":"505","author":"A Necsulea","year":"2014","unstructured":"Necsulea A, Soumillon M, Warnefors M et al (2014) The evolution of lncRNA repertoires and expression patterns in tetrapods. Nature 505(7485):635\u2013640","journal-title":"Nature"},{"issue":"1","key":"4741_CR9","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1186\/s13059-017-1331-y","volume":"18","author":"O Marin-Bejar","year":"2017","unstructured":"Marin-Bejar O, Mas AM, Gonzalez J et al (2017) The human lncRNA LINC-PINT inhibits tumor cell invasion through a highly conserved sequence element. Genome Biol 18(1):202","journal-title":"Genome Biol"},{"issue":"4","key":"4741_CR10","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1016\/j.ccell.2016.03.010","volume":"29","author":"AM Schmitt","year":"2016","unstructured":"Schmitt AM, Chang HY (2016) Long noncoding RNAs in cancer pathways. Cancer Cell 29(4):452\u2013463","journal-title":"Cancer Cell"},{"issue":"2","key":"4741_CR11","first-page":"219","volume":"37","author":"D Brauze","year":"1990","unstructured":"Brauze D, Mikstacka R, Pelkonen O (1990) Monoclonal antibody characterization of NADH- and NADPH-dependent hydroxylation of benzo(a)pyrene in liver microsomes from 5,6-benzoflavone-induced C57Bl\/6 mice. Acta Biochim Pol 37(2):219\u2013225","journal-title":"Acta Biochim Pol"},{"issue":"7291","key":"4741_CR12","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1038\/nature08975","volume":"464","author":"RA Gupta","year":"2010","unstructured":"Gupta RA, Shah N, Wang KC et al (2010) Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature 464(7291):1071\u20131076","journal-title":"Nature"},{"issue":"1","key":"4741_CR13","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1186\/s12943-020-01190-w","volume":"19","author":"C Shen","year":"2020","unstructured":"Shen C, Xuan B, Yan T et al (2020) m(6)A-dependent glycolysis enhances colorectal cancer progression. Mol Cancer 19(1):72","journal-title":"Mol Cancer"},{"issue":"12","key":"4741_CR14","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1038\/nbt.1511","volume":"26","author":"J Cox","year":"2008","unstructured":"Cox J, Mann M (2008) MaxQuant enables high peptide identification rates, individualized ppb-range mass accuracies and proteome-wide protein quantification. Nat Biotechnol 26(12):1367\u20131372","journal-title":"Nat Biotechnol"},{"issue":"1","key":"4741_CR15","doi-asserted-by":"publisher","first-page":"4594","DOI":"10.1038\/s41467-022-32283-3","volume":"13","author":"Y Lu","year":"2022","unstructured":"Lu Y, Yang A, Quan C et al (2022) A single-cell atlas of the multicellular ecosystem of primary and metastatic hepatocellular carcinoma. Nat Commun 13(1):4594","journal-title":"Nat Commun"},{"issue":"6","key":"4741_CR16","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1038\/nprot.2012.048","volume":"7","author":"J Zhang","year":"2012","unstructured":"Zhang J, Nuebel E, Wisidagama DR et al (2012) Measuring energy metabolism in cultured cells, including human pluripotent stem cells and differentiated cells. Nat Protoc 7(6):1068\u20131085","journal-title":"Nat Protoc"},{"issue":"5","key":"4741_CR17","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1074\/mcp.M200025-MCP200","volume":"1","author":"SE Ong","year":"2002","unstructured":"Ong SE, Blagoev B, Kratchmarova I et al (2002) Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics. Mol Cell Proteomics 1(5):376\u2013386","journal-title":"Mol Cell Proteomics"},{"issue":"3","key":"4741_CR18","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1021\/pr050031z","volume":"4","author":"T Wang","year":"2005","unstructured":"Wang T, Gu S, Ronni T, Du YC, Chen X (2005) In vivo dual-tagging proteomic approach in studying signaling pathways in immune response. J Proteome Res 4(3):941\u2013949","journal-title":"J Proteome Res"},{"issue":"3","key":"4741_CR19","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/s41556-018-0045-z","volume":"20","author":"H Huang","year":"2018","unstructured":"Huang H, Weng H, Sun W et al (2018) Recognition of RNA N(6)-methyladenosine by IGF2BP proteins enhances mRNA stability and translation. Nat Cell Biol 20(3):285\u2013295","journal-title":"Nat Cell Biol"},{"issue":"1","key":"4741_CR20","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1186\/s12943-019-1105-0","volume":"18","author":"Y Wang","year":"2019","unstructured":"Wang Y, Lu JH, Wu QN et al (2019) LncRNA LINRIS stabilizes IGF2BP2 and promotes the aerobic glycolysis in colorectal cancer. Mol Cancer 18(1):174","journal-title":"Mol Cancer"},{"issue":"2","key":"4741_CR21","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.ccr.2013.06.014","volume":"24","author":"KC Patra","year":"2013","unstructured":"Patra KC, Wang Q, Bhaskar PT et al (2013) Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer. Cancer Cell 24(2):213\u2013228","journal-title":"Cancer Cell"},{"issue":"6","key":"4741_CR22","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.1158\/1078-0432.CCR-16-0871","volume":"23","author":"T Kawai","year":"2017","unstructured":"Kawai T, Yasuchika K, Seo S et al (2017) Identification of keratin 19-positive cancer stem cells associating human hepatocellular carcinoma using (18)F-fluorodeoxyglucose positron emission tomography. Clin Cancer Res 23(6):1450\u20131460","journal-title":"Clin Cancer Res"},{"key":"4741_CR23","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/j.omtn.2019.10.047","volume":"19","author":"X Chen","year":"2020","unstructured":"Chen X, Wang Z, Tong F, Dong X, Wu G, Zhang R (2020) lncRNA UCA1 promotes gefitinib resistance as a ceRNA to target FOSL2 by sponging miR-143 in non-small cell lung cancer. Mol Ther Nucleic Acids 19:643\u2013653","journal-title":"Mol Ther Nucleic Acids"},{"issue":"10","key":"4741_CR24","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.15252\/embr.201744147","volume":"18","author":"XS Wu","year":"2017","unstructured":"Wu XS, Wang F, Li HF et al (2017) LncRNA-PAGBC acts as a microRNA sponge and promotes gallbladder tumorigenesis. EMBO Rep 18(10):1837\u20131853","journal-title":"EMBO Rep"},{"issue":"1","key":"4741_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12943-019-1085-0","volume":"19","author":"X Li","year":"2020","unstructured":"Li X, Li C, Zhang L et al (2020) The significance of exosomes in the development and treatment of hepatocellular carcinoma. Mol Cancer 19(1):1","journal-title":"Mol Cancer"},{"issue":"9","key":"4741_CR26","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/j.tibs.2016.07.003","volume":"41","author":"LL Chen","year":"2016","unstructured":"Chen LL (2016) Linking long noncoding RNA localization and function. Trends Biochem Sci 41(9):761\u2013772","journal-title":"Trends Biochem Sci"},{"issue":"1","key":"4741_CR27","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1038\/s41467-017-02733-4","volume":"9","author":"D DeWaal","year":"2018","unstructured":"DeWaal D, Nogueira V, Terry AR et al (2018) Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin. Nat Commun 9(1):446","journal-title":"Nat Commun"},{"issue":"4","key":"4741_CR28","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.2353\/ajpath.2009.080596","volume":"174","author":"T Amann","year":"2009","unstructured":"Amann T, Maegdefrau U, Hartmann A et al (2009) GLUT1 expression is increased in hepatocellular carcinoma and promotes tumorigenesis. Am J Pathol 174(4):1544\u20131552","journal-title":"Am J Pathol"},{"key":"4741_CR29","doi-asserted-by":"publisher","first-page":"7882","DOI":"10.1038\/ncomms8882","volume":"6","author":"V Iansante","year":"2015","unstructured":"Iansante V, Choy PM, Fung SW et al (2015) PARP14 promotes the Warburg effect in hepatocellular carcinoma by inhibiting JNK1-dependent PKM2 phosphorylation and activation. Nat Commun 6:7882","journal-title":"Nat Commun"},{"issue":"5","key":"4741_CR30","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1016\/j.ccell.2014.09.005","volume":"26","author":"SA Melo","year":"2014","unstructured":"Melo SA, Sugimoto H, O\u2019Connell JT et al (2014) Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis. Cancer Cell 26(5):707\u2013721","journal-title":"Cancer Cell"},{"issue":"4","key":"4741_CR31","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/j.ccr.2014.03.007","volume":"25","author":"W Zhou","year":"2014","unstructured":"Zhou W, Fong MY, Min Y et al (2014) Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis. Cancer Cell 25(4):501\u2013515","journal-title":"Cancer Cell"}],"container-title":["Cellular and Molecular Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-023-04741-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00018-023-04741-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-023-04741-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T06:21:03Z","timestamp":1681712463000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00018-023-04741-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,18]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["4741"],"URL":"https:\/\/doi.org\/10.1007\/s00018-023-04741-8","relation":{},"ISSN":["1420-682X","1420-9071"],"issn-type":[{"value":"1420-682X","type":"print"},{"value":"1420-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,18]]},"assertion":[{"value":"10 October 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 February 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 March 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 March 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No potential conflicts of interest were disclosed.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Animal experiments were carried out in accordance with the standards approved by the Ethics Committee of The Seventh People\u2019s Hospital of Shanghai University of Traditional Chinese Medicine.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The use of samples from patients was conducted according to the guidelines of the Declaration of Helsinki and approved by the Ethics Committee of The Seventh People\u2019s Hospital of Shanghai University of Traditional Chinese Medicine. The need to obtain informed consent from the study patients was waived.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}],"article-number":"99"}}