{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T20:32:12Z","timestamp":1793046732490,"version":"4.5.0"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T00:00:00Z","timestamp":1680739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T00:00:00Z","timestamp":1680739200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100014718","name":"Innovative Research Group Project of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170331"],"award-info":[{"award-number":["82170331"]}],"id":[{"id":"10.13039\/100014718","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014718","name":"Innovative Research Group Project of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U21A20337"],"award-info":[{"award-number":["U21A20337"]}],"id":[{"id":"10.13039\/100014718","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014718","name":"Innovative Research Group Project of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170489"],"award-info":[{"award-number":["82170489"]}],"id":[{"id":"10.13039\/100014718","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LR22H020001"],"award-info":[{"award-number":["LR22H020001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY23H010007"],"award-info":[{"award-number":["LY23H010007"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["WKJ-ZJ-2312"],"award-info":[{"award-number":["WKJ-ZJ-2312"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell. Mol. Life Sci."],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Regeneration of smooth muscle cells (SMCs) is vital in vascular remodeling. Sca1<jats:sup>+<\/jats:sup> stem\/progenitor cells (SPCs) can generate de novo smooth muscle cells after severe vascular injury during vessel repair and regeneration. However, the underlying mechanisms have not been conclusively determined. Here, we reported that lncRNA Metastasis-associated lung adenocarcinoma transcript 1 (Malat1) was down-regulated in various vascular diseases including arteriovenous fistula, artery injury and atherosclerosis. Using genetic lineage tracing mice and veingraft mice surgery model, we found that suppression of lncRNA Malat1 promoted Sca1<jats:sup>+<\/jats:sup> cells to differentiate into SMCs in vivo, resulting in excess SMC accumulation in neointima and vessel stenosis. Genetic ablation of Sca1<jats:sup>+<\/jats:sup> cells attenuated venous arterialization and impaired vascular structure normalization, and thus, resulting in less Malat1 down-regulation. Single cell sequencing further revealed a fibroblast-like phenotype of Sca1<jats:sup>+<\/jats:sup> SPCs-derived SMCs. Protein array sequencing and in vitro assays revealed that SMC regeneration from Sca1<jats:sup>+<\/jats:sup> SPCs was regulated by Malat1 through miR125a-5p\/Stat3 signaling pathway. These findings delineate the critical role of Sca1<jats:sup>+<\/jats:sup> SPCs in vascular remodeling and reveal that lncRNA Malat1 is a key regulator and might serve as a novel biomarker or potential therapeutic target for vascular diseases.<\/jats:p>","DOI":"10.1007\/s00018-023-04762-3","type":"journal-article","created":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T13:05:29Z","timestamp":1680786329000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Fate mapping RNA-sequencing reveal Malat1 regulates Sca1+ progenitor cells to vascular smooth muscle cells transition in vascular remodeling"],"prefix":"10.1007","volume":"80","author":[{"given":"Lingxia","family":"Lyu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhoubin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuoshi","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongchun","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuliang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liujun","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuhao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengchen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6754-1432","authenticated-orcid":false,"given":"Xiaogang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,4,6]]},"reference":[{"issue":"Suppl 1","key":"4762_CR1","first-page":"S176","volume":"48","author":"Vascular Access Work Group","year":"2006","unstructured":"Vascular Access Work Group (2006) Clinical practice guidelines for vascular access. Am J Kidney Dis 48(Suppl 1):S176\u2013S247","journal-title":"Am J Kidney Dis"},{"issue":"6","key":"4762_CR2","doi-asserted-by":"publisher","first-page":"954","DOI":"10.2215\/CJN.00490119","volume":"14","author":"M Allon","year":"2019","unstructured":"Allon M (2019) Vascular access for hemodialysis patients: new data should guide decision making. Clin J Am Soc Nephrol 14(6):954\u2013961","journal-title":"Clin J Am Soc Nephrol"},{"issue":"4","key":"4762_CR3","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1681\/ASN.V74523","volume":"7","author":"HI Feldman","year":"1996","unstructured":"Feldman HI, Kobrin S, Wasserstein A (1996) Hemodialysis vascular access morbidity. J Am Soc Nephrol 7(4):523\u2013535","journal-title":"J Am Soc Nephrol"},{"issue":"4","key":"4762_CR4","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1681\/ASN.2005050615","volume":"17","author":"P Roy-Chaudhury","year":"2006","unstructured":"Roy-Chaudhury P, Sukhatme VP, Cheung AK (2006) Hemodialysis vascular access dysfunction: a cellular and molecular viewpoint. J Am Soc Nephrol 17(4):1112\u20131127","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"4762_CR5","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1055\/s-0037-1606180","volume":"44","author":"A Masud","year":"2018","unstructured":"Masud A et al (2018) The complications of vascular access in hemodialysis. Semin Thromb Hemost 44(1):57\u201359","journal-title":"Semin Thromb Hemost"},{"issue":"9","key":"4762_CR6","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1161\/01.CIR.97.9.916","volume":"97","author":"JG Motwani","year":"1998","unstructured":"Motwani JG, Topol EJ (1998) Aortocoronary saphenous vein graft disease: pathogenesis, predisposition, and prevention. Circulation 97(9):916\u2013931","journal-title":"Circulation"},{"issue":"7","key":"4762_CR7","doi-asserted-by":"publisher","first-page":"e13","DOI":"10.1161\/01.RES.0000037090.34760.EE","volume":"91","author":"Y Hu","year":"2002","unstructured":"Hu Y et al (2002) Both donor and recipient origins of smooth muscle cells in vein graft atherosclerotic lesions. Circ Res 91(7):e13-20","journal-title":"Circ Res"},{"issue":"4","key":"4762_CR8","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.004891","volume":"6","author":"J Zhao","year":"2017","unstructured":"Zhao J et al (2017) Dual function for mature vascular smooth muscle cells during arteriovenous fistula remodeling. J Am Heart Assoc 6(4):e004891","journal-title":"J Am Heart Assoc"},{"key":"4762_CR9","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1038\/ncomms1867","volume":"3","author":"Z Tang","year":"2012","unstructured":"Tang Z et al (2012) Differentiation of multipotent vascular stem cells contributes to vascular diseases. Nat Commun 3:875","journal-title":"Nat Commun"},{"issue":"9","key":"4762_CR10","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1172\/JCI19628","volume":"113","author":"Y Hu","year":"2004","unstructured":"Hu Y et al (2004) Abundant progenitor cells in the adventitia contribute to atherosclerosis of vein grafts in ApoE-deficient mice. J Clin Investig 113(9):1258\u20131265","journal-title":"J Clin Investig"},{"issue":"2","key":"4762_CR11","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1161\/CIRCRESAHA.117.312111","volume":"122","author":"U Roostalu","year":"2018","unstructured":"Roostalu U et al (2018) Distinct cellular mechanisms underlie smooth muscle turnover in vascular development and repair. Circ Res 122(2):267\u2013281","journal-title":"Circ Res"},{"issue":"1","key":"4762_CR12","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.stem.2019.11.010","volume":"26","author":"J Tang","year":"2020","unstructured":"Tang J et al (2020) Arterial Sca1(+) vascular stem cells generate de novo smooth muscle for artery repair and regeneration. Cell Stem Cell 26(1):81-96 e4","journal-title":"Cell Stem Cell"},{"key":"4762_CR13","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/1471-2164-8-39","volume":"8","author":"JN Hutchinson","year":"2007","unstructured":"Hutchinson JN et al (2007) A screen for nuclear transcripts identifies two linked noncoding RNAs associated with SC35 splicing domains. BMC Genom 8:39","journal-title":"BMC Genom"},{"issue":"39","key":"4762_CR14","doi-asserted-by":"publisher","first-page":"8031","DOI":"10.1038\/sj.onc.1206928","volume":"22","author":"P Ji","year":"2003","unstructured":"Ji P et al (2003) MALAT-1, a novel noncoding RNA, and thymosin beta4 predict metastasis and survival in early-stage non-small cell lung cancer. Oncogene 22(39):8031\u20138041","journal-title":"Oncogene"},{"issue":"31","key":"4762_CR15","doi-asserted-by":"publisher","first-page":"12956","DOI":"10.1073\/pnas.0906005106","volume":"106","author":"L Li","year":"2009","unstructured":"Li L et al (2009) Role of human noncoding RNAs in the control of tumorigenesis. Proc Natl Acad Sci USA 106(31):12956\u201312961","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"4762_CR16","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1038\/bjc.2014.383","volume":"111","author":"Q Ji","year":"2014","unstructured":"Ji Q et al (2014) Long non-coding RNA MALAT1 promotes tumour growth and metastasis in colorectal cancer through binding to SFPQ and releasing oncogene PTBP2 from SFPQ\/PTBP2 complex. Br J Cancer 111(4):736\u2013748","journal-title":"Br J Cancer"},{"issue":"5","key":"4762_CR17","doi-asserted-by":"publisher","first-page":"101042831769979","DOI":"10.1177\/1010428317699796","volume":"39","author":"S Bi","year":"2017","unstructured":"Bi S et al (2017) LncRNA-MALAT1-mediated Axl promotes cell invasion and migration in human neuroblastoma. Tumour Biol 39(5):1010428317699796","journal-title":"Tumour Biol"},{"issue":"4","key":"4762_CR18","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1158\/1535-7163.MCT-16-0591","volume":"16","author":"P Li","year":"2017","unstructured":"Li P et al (2017) MALAT1 Is associated with poor response to oxaliplatin-based chemotherapy in colorectal cancer patients and promotes chemoresistance through EZH2. Mol Cancer Ther 16(4):739\u2013751","journal-title":"Mol Cancer Ther"},{"issue":"3","key":"4762_CR19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003368","volume":"9","author":"V Tripathi","year":"2013","unstructured":"Tripathi V et al (2013) Long noncoding RNA MALAT1 controls cell cycle progression by regulating the expression of oncogenic transcription factor B-MYB. PLoS Genet 9(3):e1003368","journal-title":"PLoS Genet"},{"issue":"6","key":"4762_CR20","doi-asserted-by":"publisher","first-page":"806","DOI":"10.4161\/cbt.28584","volume":"15","author":"XS Wu","year":"2014","unstructured":"Wu XS et al (2014) MALAT1 promotes the proliferation and metastasis of gallbladder cancer cells by activating the ERK\/MAPK pathway. Cancer Biol Ther 15(6):806\u2013814","journal-title":"Cancer Biol Ther"},{"issue":"1","key":"4762_CR21","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/s11060-014-1613-0","volume":"121","author":"L Shen","year":"2015","unstructured":"Shen L et al (2015) Long noncoding RNA MALAT1 promotes brain metastasis by inducing epithelial-mesenchymal transition in lung cancer. J Neurooncol 121(1):101\u2013108","journal-title":"J Neurooncol"},{"issue":"9","key":"4762_CR22","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1161\/CIRCRESAHA.114.303265","volume":"114","author":"KM Michalik","year":"2014","unstructured":"Michalik KM et al (2014) Long noncoding RNA MALAT1 regulates endothelial cell function and vessel growth. Circ Res 114(9):1389\u20131397","journal-title":"Circ Res"},{"issue":"5","key":"4762_CR23","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1177\/1535370216685434","volume":"242","author":"M Brock","year":"2017","unstructured":"Brock M et al (2017) Analysis of hypoxia-induced noncoding RNAs reveals metastasis-associated lung adenocarcinoma transcript 1 as an important regulator of vascular smooth muscle cell proliferation. Exp Biol Med (Maywood) 242(5):487\u2013496","journal-title":"Exp Biol Med (Maywood)"},{"issue":"10","key":"4762_CR24","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1161\/CIRCULATIONAHA.117.029015","volume":"139","author":"S Cremer","year":"2019","unstructured":"Cremer S et al (2019) Hematopoietic deficiency of the long noncoding RNA MALAT1 promotes atherosclerosis and plaque inflammation. Circulation 139(10):1320\u20131334","journal-title":"Circulation"},{"issue":"8","key":"4762_CR25","doi-asserted-by":"publisher","first-page":"e146","DOI":"10.1161\/CIRCRESAHA.121.319494","volume":"129","author":"L Jiang","year":"2021","unstructured":"Jiang L et al (2021) Nonbone marrow CD34(+) cells are crucial for endothelial repair of injured artery. Circ Res 129(8):e146\u2013e165","journal-title":"Circ Res"},{"issue":"8","key":"4762_CR26","first-page":"5150","volume":"11","author":"X Tang","year":"2019","unstructured":"Tang X et al (2019) Molecular mechanisms involved in TGF-beta1-induced muscle-derived stem cells differentiation to smooth muscle cells. Am J Transl Res 11(8):5150\u20135161","journal-title":"Am J Transl Res"},{"issue":"2","key":"4762_CR27","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1161\/CIRCRESAHA.119.314855","volume":"125","author":"Z Ni","year":"2019","unstructured":"Ni Z et al (2019) Recipient c-kit lineage cells repopulate smooth muscle cells of transplant arteriosclerosis in mouse models. Circ Res 125(2):223\u2013241","journal-title":"Circ Res"},{"issue":"12","key":"4762_CR28","doi-asserted-by":"publisher","first-page":"1705","DOI":"10.1093\/cvr\/cvz185","volume":"115","author":"K van Kuijk","year":"2019","unstructured":"van Kuijk K et al (2019) Heterogeneity and plasticity in healthy and atherosclerotic vasculature explored by single-cell sequencing. Cardiovasc Res 115(12):1705\u20131715","journal-title":"Cardiovasc Res"},{"issue":"1","key":"4762_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0002-9440(10)63270-1","volume":"165","author":"Q Xu","year":"2004","unstructured":"Xu Q (2004) Mouse models of arteriosclerosis: from arterial injuries to vascular grafts. Am J Pathol 165(1):1\u201310","journal-title":"Am J Pathol"},{"issue":"3","key":"4762_CR30","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1161\/01.RES.77.3.445","volume":"77","author":"SM Schwartz","year":"1995","unstructured":"Schwartz SM, de Blois D, Obrien ER (1995) The intima. Soil for atherosclerosis and restenosis. Circ Res 77(3):445\u2013465","journal-title":"Circ Res"},{"issue":"12","key":"4762_CR31","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1038\/s41569-019-0227-9","volume":"16","author":"GL Basatemur","year":"2019","unstructured":"Basatemur GL et al (2019) Vascular smooth muscle cells in atherosclerosis. Nat Rev Cardiol 16(12):727\u2013744","journal-title":"Nat Rev Cardiol"},{"issue":"6","key":"4762_CR32","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1038\/nmeth762","volume":"2","author":"T Buch","year":"2005","unstructured":"Buch T et al (2005) A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration. Nat Methods 2(6):419\u2013426","journal-title":"Nat Methods"},{"issue":"6","key":"4762_CR33","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1016\/0092-8674(92)90623-K","volume":"69","author":"JG Naglich","year":"1992","unstructured":"Naglich JG et al (1992) Expression cloning of a diphtheria toxin receptor: identity with a heparin-binding EGF-like growth factor precursor. Cell 69(6):1051\u20131061","journal-title":"Cell"},{"issue":"3","key":"4762_CR34","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1038\/s41419-022-04605-2","volume":"13","author":"F Kleefeldt","year":"2022","unstructured":"Kleefeldt F et al (2022) Bone marrow-independent adventitial macrophage progenitor cells contribute to angiogenesis. Cell Death Dis 13(3):220","journal-title":"Cell Death Dis"},{"issue":"6","key":"4762_CR35","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1038\/nm.3866","volume":"21","author":"LS Shankman","year":"2015","unstructured":"Shankman LS et al (2015) KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis. Nat Med 21(6):628\u2013637","journal-title":"Nat Med"},{"issue":"8","key":"4762_CR36","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1038\/s41591-019-0512-5","volume":"25","author":"RC Wirka","year":"2019","unstructured":"Wirka RC et al (2019) Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis. Nat Med 25(8):1280\u20131289","journal-title":"Nat Med"},{"issue":"9932","key":"4762_CR37","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.1016\/S0140-6736(14)60107-0","volume":"383","author":"G Heusch","year":"2014","unstructured":"Heusch G et al (2014) Cardiovascular remodelling in coronary artery disease and heart failure. Lancet 383(9932):1933\u20131943","journal-title":"Lancet"},{"issue":"2","key":"4762_CR38","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1093\/cvr\/cvs115","volume":"95","author":"D Gomez","year":"2012","unstructured":"Gomez D, Owens GK (2012) Smooth muscle cell phenotypic switching in atherosclerosis. Cardiovasc Res 95(2):156\u2013164","journal-title":"Cardiovasc Res"},{"issue":"25","key":"4762_CR39","doi-asserted-by":"publisher","first-page":"11428","DOI":"10.7150\/thno.47432","volume":"10","author":"G Deng","year":"2020","unstructured":"Deng G et al (2020) BET inhibitor suppresses melanoma progression via the noncanonical NF-kappaB\/SPP1 pathway. Theranostics 10(25):11428\u201311443","journal-title":"Theranostics"},{"issue":"14","key":"4762_CR40","doi-asserted-by":"publisher","first-page":"1394","DOI":"10.1161\/CIRCULATIONAHA.120.047375","volume":"143","author":"L Wang","year":"2021","unstructured":"Wang L et al (2021) BMP9 and BMP10 act directly on vascular smooth muscle cells for generation and maintenance of the contractile state. Circulation 143(14):1394\u20131410","journal-title":"Circulation"},{"issue":"4","key":"4762_CR41","doi-asserted-by":"publisher","first-page":"410","DOI":"10.2183\/pjab.86.410","volume":"86","author":"T Muramatsu","year":"2010","unstructured":"Muramatsu T (2010) Midkine, a heparin-binding cytokine with multiple roles in development, repair and diseases. Proc Jpn Acad Ser B Phys Biol Sci 86(4):410\u2013425","journal-title":"Proc Jpn Acad Ser B Phys Biol Sci"},{"issue":"4","key":"4762_CR42","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1248\/bpb.b13-00845","volume":"37","author":"C Xu","year":"2014","unstructured":"Xu C et al (2014) Functional receptors and intracellular signal pathways of midkine (MK) and pleiotrophin (PTN). Biol Pharm Bull 37(4):511\u2013520","journal-title":"Biol Pharm Bull"},{"issue":"1","key":"4762_CR43","doi-asserted-by":"publisher","first-page":"C342","DOI":"10.1152\/ajpcell.00341.2006","volume":"292","author":"Q Xiao","year":"2007","unstructured":"Xiao Q et al (2007) Stem cell-derived Sca-1+ progenitors differentiate into smooth muscle cells, which is mediated by collagen IV-integrin alpha1\/beta1\/alphav and PDGF receptor pathways. Am J Physiol Cell Physiol 292(1):C342\u2013C352","journal-title":"Am J Physiol Cell Physiol"},{"issue":"2","key":"4762_CR44","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1161\/01.ATV.0000197793.83391.91","volume":"26","author":"J Sainz","year":"2006","unstructured":"Sainz J et al (2006) Isolation of \u201cside population\u201d progenitor cells from healthy arteries of adult mice. Arterioscler Thromb Vasc Biol 26(2):281\u2013286","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"3","key":"4762_CR45","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1083\/jcb.141.3.805","volume":"141","author":"KK Hirschi","year":"1998","unstructured":"Hirschi KK, Rohovsky SA, D\u2019Amore PA (1998) PDGF, TGF-beta, and heterotypic cell-cell interactions mediate endothelial cell-induced recruitment of 10T1\/2 cells and their differentiation to a smooth muscle fate. J Cell Biol 141(3):805\u2013814","journal-title":"J Cell Biol"},{"issue":"6","key":"4762_CR46","doi-asserted-by":"publisher","first-page":"C1560","DOI":"10.1152\/ajpcell.00221.2004","volume":"287","author":"S Sinha","year":"2004","unstructured":"Sinha S et al (2004) Transforming growth factor-beta1 signaling contributes to development of smooth muscle cells from embryonic stem cells. Am J Physiol Cell Physiol 287(6):C1560\u2013C1568","journal-title":"Am J Physiol Cell Physiol"},{"key":"4762_CR47","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.2147\/CMAR.S243796","volume":"12","author":"Q Dai","year":"2020","unstructured":"Dai Q, Zhang T, Li C (2020) LncRNA MALAT1 regulates the cell proliferation and cisplatin resistance in gastric cancer via PI3K\/AKT pathway. Cancer Manag Res 12:1929\u20131939","journal-title":"Cancer Manag Res"},{"issue":"3","key":"4762_CR48","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1046\/j.1523-1755.2002.00191.x","volume":"61","author":"S Stracke","year":"2002","unstructured":"Stracke S et al (2002) Increased expression of TGF-beta1 and IGF-I in inflammatory stenotic lesions of hemodialysis fistulas. Kidney Int 61(3):1011\u20131019","journal-title":"Kidney Int"},{"issue":"1","key":"4762_CR49","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1159\/000067863","volume":"21","author":"P Roy-Chaudhury","year":"2003","unstructured":"Roy-Chaudhury P et al (2003) Hemodialysis vascular access dysfunction: from pathophysiology to novel therapies. Blood Purif 21(1):99\u2013110","journal-title":"Blood Purif"},{"issue":"1","key":"4762_CR50","doi-asserted-by":"publisher","first-page":"4567","DOI":"10.1038\/s41467-018-06891-x","volume":"9","author":"L Dobnikar","year":"2018","unstructured":"Dobnikar L et al (2018) Disease-relevant transcriptional signatures identified in individual smooth muscle cells from healthy mouse vessels. Nat Commun 9(1):4567","journal-title":"Nat Commun"},{"issue":"16","key":"4762_CR51","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.017420","volume":"9","author":"C Cai","year":"2020","unstructured":"Cai C et al (2020) Differences in transforming growth factor-beta1\/BMP7 signaling and venous fibrosis contribute to female sex differences in arteriovenous fistulas. J Am Heart Assoc 9(16):e017420","journal-title":"J Am Heart Assoc"},{"issue":"6","key":"4762_CR52","doi-asserted-by":"publisher","first-page":"1418","DOI":"10.1111\/jcmm.12576","volume":"19","author":"P Puthanveetil","year":"2015","unstructured":"Puthanveetil P et al (2015) Long non-coding RNA MALAT1 regulates hyperglycaemia induced inflammatory process in the endothelial cells. J Cell Mol Med 19(6):1418\u20131425","journal-title":"J Cell Mol Med"},{"issue":"5","key":"4762_CR53","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1038\/s41419-020-2508-y","volume":"11","author":"Q Wu","year":"2020","unstructured":"Wu Q et al (2020) Extracellular vesicles from human embryonic stem cell-derived cardiovascular progenitor cells promote cardiac infarct healing through reducing cardiomyocyte death and promoting angiogenesis. Cell Death Dis 11(5):354","journal-title":"Cell Death Dis"},{"issue":"1","key":"4762_CR54","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1038\/s41467-018-03394-7","volume":"9","author":"CL Lino Cardenas","year":"2018","unstructured":"Lino Cardenas CL et al (2018) An HDAC9-MALAT1-BRG1 complex mediates smooth muscle dysfunction in thoracic aortic aneurysm. Nat Commun 9(1):1009","journal-title":"Nat Commun"},{"issue":"4","key":"4762_CR55","doi-asserted-by":"publisher","first-page":"4411","DOI":"10.18632\/oncotarget.23230","volume":"9","author":"TF Song","year":"2018","unstructured":"Song TF et al (2018) LncRNA MALAT1 regulates smooth muscle cell phenotype switch via activation of autophagy. Oncotarget 9(4):4411\u20134426","journal-title":"Oncotarget"},{"issue":"1","key":"4762_CR56","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1038\/s41392-022-00943-x","volume":"7","author":"L Yu","year":"2022","unstructured":"Yu L et al (2022) An intersegmental single-cell profile reveals aortic heterogeneity and identifies a novel Malat1(+) vascular smooth muscle subtype involved in abdominal aortic aneurysm formation. Signal Transduct Target Ther 7(1):125","journal-title":"Signal Transduct Target Ther"}],"container-title":["Cellular and Molecular Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-023-04762-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00018-023-04762-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-023-04762-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T10:14:46Z","timestamp":1684318486000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00018-023-04762-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,6]]},"references-count":56,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["4762"],"URL":"https:\/\/doi.org\/10.1007\/s00018-023-04762-3","relation":{},"ISSN":["1420-682X","1420-9071"],"issn-type":[{"value":"1420-682X","type":"print"},{"value":"1420-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,6]]},"assertion":[{"value":"6 October 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 February 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 March 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 April 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Studies involving human participants were reviewed and approved by the Research Ethics Committee of the First Affiliated Hospital, School of Medicine, Zhejiang University (Institutional Review Board Approval No. 2021\/330). The patients\/participants provided written informed consent to participate in this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors read and approved the manuscript for publication. The authors affirmed that human research participants provided informed consent for the publication of images in Fig.\u00a0A\u2013E.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}],"article-number":"118"}}