{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T20:46:42Z","timestamp":1776286002687,"version":"3.50.1"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T00:00:00Z","timestamp":1691539200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T00:00:00Z","timestamp":1691539200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Lingnan Modern Agriculture Project","award":["NT2021005"],"award-info":[{"award-number":["NT2021005"]}]},{"DOI":"10.13039\/501100012166","name":"National Key R & D Program of China","doi-asserted-by":"crossref","award":["2020YFA0509500"],"award-info":[{"award-number":["2020YFA0509500"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Key R & D Program of China","doi-asserted-by":"crossref","award":["2021YFA0805903"],"award-info":[{"award-number":["2021YFA0805903"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100014219","name":"National Science Fund for Distinguished Young Scholars","doi-asserted-by":"publisher","award":["32025034"],"award-info":[{"award-number":["32025034"]}],"id":[{"id":"10.13039\/501100014219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014219","name":"National Science Fund for Distinguished Young Scholars","doi-asserted-by":"publisher","award":["31925036"],"award-info":[{"award-number":["31925036"]}],"id":[{"id":"10.13039\/501100014219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012421","name":"Agricultural Science and Technology Innovation Program","doi-asserted-by":"crossref","award":["ASTIP-IAS05"],"award-info":[{"award-number":["ASTIP-IAS05"]}],"id":[{"id":"10.13039\/501100012421","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell. Mol. Life Sci."],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1007\/s00018-023-04896-4","type":"journal-article","created":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T08:02:35Z","timestamp":1691568155000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Adipocyte Rnf20 ablation increases the fast-twitch fibers of skeletal muscle via lysophosphatidylcholine 16:0"],"prefix":"10.1007","volume":"80","author":[{"given":"Ying","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuanhe","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianfei","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sin Man","family":"Lam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guanghou","family":"Shui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shulin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianwen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cong","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianguo","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1492-6771","authenticated-orcid":false,"given":"Yanfang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,8,9]]},"reference":[{"key":"4896_CR1","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1038\/s41467-020-20760-6","volume":"121","author":"F Relaix","year":"2021","unstructured":"Relaix F, Bencze M, Borok MJ, Der Vartanian A, Gattazzo F, Mademtzoglou D, Perez-Diaz S, Prola A, Reyes-Fernandez PC, Rotini A, Taglietti T (2021) Perspectives on skeletal muscle stem cells. Nat Commun 121:692. https:\/\/doi.org\/10.1038\/s41467-020-20760-6","journal-title":"Nat Commun"},{"key":"4896_CR2","doi-asserted-by":"publisher","first-page":"1645","DOI":"10.1002\/cphy.c130009","volume":"34","author":"B Blaauw","year":"2013","unstructured":"Blaauw B, Schiaffino S, Reggiani C (2013) Mechanisms modulating skeletal muscle phenotype. Compr Physiol 34:1645\u20131687. https:\/\/doi.org\/10.1002\/cphy.c130009","journal-title":"Compr Physiol"},{"key":"4896_CR3","doi-asserted-by":"publisher","first-page":"e348","DOI":"10.1371\/journal.pbio.0020348","volume":"210","author":"JR Zierath","year":"2004","unstructured":"Zierath JR, Hawley JA (2004) Skeletal muscle fiber type: influence on contractile and metabolic properties. PLoS Biol 210:e348. https:\/\/doi.org\/10.1371\/journal.pbio.0020348","journal-title":"PLoS Biol"},{"key":"4896_CR4","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1152\/physrev.00031.2010","volume":"914","author":"S Schiaffino","year":"2011","unstructured":"Schiaffino S, Reggiani C (2011) Fiber types in mammalian skeletal muscles. Physiol Rev 914:1447\u20131531. https:\/\/doi.org\/10.1152\/physrev.00031.2010","journal-title":"Physiol Rev"},{"key":"4896_CR5","doi-asserted-by":"publisher","first-page":"e47892","DOI":"10.15252\/embr.201947892","volume":"209","author":"T Wang","year":"2019","unstructured":"Wang T, Xu YQ, Yuan YX, Xu PW, Zhang C, Li F, Wang LN, Yin C, Zhang L, Cai XC, Zhu CJ, Xu JR, Liang BQ, Schaul S, Xie PP, Yue D, Liao ZR, Yu LL, Luo L, Zhou G, Yang JP, He ZH, Du M, Zhou YP, Deng BC, Wang SB, Gao P, Zhu XT, Xi QY, Zhang YL, Shu G, Jiang QY (2019) Succinate induces skeletal muscle fiber remodeling via Suncr1 signaling. EMBO Rep 209:e47892. https:\/\/doi.org\/10.15252\/embr.201947892","journal-title":"EMBO Rep"},{"key":"4896_CR6","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/nrendo.2012.49","volume":"88","author":"BK Pedersen","year":"2012","unstructured":"Pedersen BK, Febbraio MA (2012) Muscles, exercise and obesity: skeletal muscle as a secretory organ. Nat Rev Endocrinol 88:457\u2013465. https:\/\/doi.org\/10.1038\/nrendo.2012.49","journal-title":"Nat Rev Endocrinol"},{"key":"4896_CR7","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1080\/13813450802535812","volume":"1145","author":"J Ukropec","year":"2008","unstructured":"Ukropec J, Ukropcova B, Kurdiova T, Gasperikova D, Klimes I (2008) Adipose tissue and skeletal muscle plasticity modulates metabolic health. Arch Physiol Biochem 1145:357\u2013368. https:\/\/doi.org\/10.1080\/13813450802535812","journal-title":"Arch Physiol Biochem"},{"key":"4896_CR8","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1111\/j.1745-7254.2007.00523.x","volume":"283","author":"HQ Fan","year":"2007","unstructured":"Fan HQ, Gu N, Liu F, Fei L, Pan XQ, Guo M, Chen RH, Guo XR (2007) Prolonged exposure to resistin inhibits glucose uptake in rat skeletal muscles. Acta Pharmacol Sin 283:410\u2013416. https:\/\/doi.org\/10.1111\/j.1745-7254.2007.00523.x","journal-title":"Acta Pharmacol Sin"},{"key":"4896_CR9","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.2337\/diab.46.8.1360","volume":"468","author":"DM Muoio","year":"1997","unstructured":"Muoio DM, Dohm GL, Fiedorek FT Jr, Tapscott EB, Coleman RA (1997) Leptin directly alters lipid partitioning in skeletal muscle. Diabetes 468:1360\u20131363. https:\/\/doi.org\/10.2337\/diab.46.8.1360","journal-title":"Diabetes"},{"key":"4896_CR10","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1038\/nm788","volume":"811","author":"T Yamauchi","year":"2002","unstructured":"Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S, Yamashita S, Noda M, Kita S, Ueki K, Eto K, Akanuma Y, Froguel P, Foufelle F, Ferre P, Carling D, Kimura S, Nagai R, Kahn BB, Kadowaki T (2002) Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating amp-activated protein kinase. Nat Med 811:1288\u20131295. https:\/\/doi.org\/10.1038\/nm788","journal-title":"Nat Med"},{"issue":"Pt 2","key":"4896_CR11","doi-asserted-by":"publisher","first-page":"R659","DOI":"10.1152\/ajpregu.1989.256.3.R659","volume":"2563","author":"Y Fong","year":"1989","unstructured":"Fong Y, Moldawer LL, Marano M, Wei H, Barber A, Manogue K, Tracey KJ, Kuo G, Fischman DA, Cerami A et al (1989) Cachectin\/Tnf or Il-1 alpha induces cachexia with redistribution of body proteins. Am J Physiol 2563(Pt 2):R659\u2013R665. https:\/\/doi.org\/10.1152\/ajpregu.1989.256.3.R659","journal-title":"Am J Physiol"},{"key":"4896_CR12","doi-asserted-by":"publisher","first-page":"1648","DOI":"10.1194\/jlr.R094060","volume":"6010","author":"JB Funcke","year":"2019","unstructured":"Funcke JB, Scherer PE (2019) Beyond adiponectin and leptin: adipose tissue-derived mediators of inter-organ communication. J Lipid Res 6010:1648\u20131684. https:\/\/doi.org\/10.1194\/jlr.R094060","journal-title":"J Lipid Res"},{"key":"4896_CR13","doi-asserted-by":"publisher","first-page":"5696","DOI":"10.1210\/en.2007-0183","volume":"14812","author":"Q Zhou","year":"2007","unstructured":"Zhou Q, Du J, Hu Z, Walsh K, Wang XH (2007) Evidence for adipose-muscle cross talk: opposing regulation of muscle proteolysis by adiponectin and fatty acids. Endocrinology 14812:5696\u20135705. https:\/\/doi.org\/10.1210\/en.2007-0183","journal-title":"Endocrinology"},{"key":"4896_CR14","doi-asserted-by":"publisher","first-page":"1394","DOI":"10.1007\/s00125-013-2891-3","volume":"566","author":"C Rancoule","year":"2013","unstructured":"Rancoule C, Attane C, Gres S, Fournel A, Dusaulcy R, Bertrand C, Vinel C, Treguer K, Prentki M, Valet P, Saulnier-Blache JS (2013) Lysophosphatidic acid impairs glucose homeostasis and inhibits insulin secretion in high-fat diet obese mice. Diabetologia 566:1394\u20131402. https:\/\/doi.org\/10.1007\/s00125-013-2891-3","journal-title":"Diabetologia"},{"key":"4896_CR15","doi-asserted-by":"publisher","first-page":"2579","DOI":"10.2337\/db06-0330","volume":"559","author":"F Samad","year":"2006","unstructured":"Samad F, Hester KD, Yang G, Hannun YA, Bielawski J (2006) Altered adipose and plasma sphingolipid metabolism in obesity: a potential mechanism for cardiovascular and metabolic risk. Diabetes 559:2579\u20132587. https:\/\/doi.org\/10.2337\/db06-0330","journal-title":"Diabetes"},{"key":"4896_CR16","doi-asserted-by":"publisher","first-page":"5337","DOI":"10.1210\/jc.2003-031658","volume":"8911","author":"MC Vantyghem","year":"2004","unstructured":"Vantyghem MC, Pigny P, Maurage CA, Rouaix-Emery N, Stojkovic T, Cuisset JM, Millaire A, Lascols O, Vermersch P, Wemeau JL, Capeau J, Vigouroux C (2004) Patients with familial partial lipodystrophy of the dunnigan type due to a Lmna R482w mutation show muscular and cardiac abnormalities. J Clin Endocrinol Metab 8911:5337\u20135346. https:\/\/doi.org\/10.1210\/jc.2003-031658","journal-title":"J Clin Endocrinol Metab"},{"key":"4896_CR17","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1177\/0300985818809126","volume":"562","author":"RS Sellers","year":"2019","unstructured":"Sellers RS, Mahmood SR, Perumal GS, Macaluso FP, Kurland IJ (2019) Phenotypic modulation of skeletal muscle fibers in Lpin1-deficient lipodystrophic ( Fld) mice. Vet Pathol 562:322\u2013331. https:\/\/doi.org\/10.1177\/0300985818809126","journal-title":"Vet Pathol"},{"key":"4896_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.mce.2018.12.001","volume":"482","author":"W Xu","year":"2019","unstructured":"Xu W, Zhou H, Xuan H, Saha P, Wang G, Chen W (2019) Novel metabolic disorders in skeletal muscle of lipodystrophic Bscl2\/seipin deficient mice. Mol Cell Endocrinol 482:1\u201310. https:\/\/doi.org\/10.1016\/j.mce.2018.12.001","journal-title":"Mol Cell Endocrinol"},{"key":"4896_CR19","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1016\/j.bbagrm.2014.01.002","volume":"18398","author":"G Fuchs","year":"2014","unstructured":"Fuchs G, Oren M (2014) Writing and reading H2b monoubiquitylation. Biochim Biophys Acta 18398:694\u2013701. https:\/\/doi.org\/10.1016\/j.bbagrm.2014.01.002","journal-title":"Biochim Biophys Acta"},{"key":"4896_CR20","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1093\/abbs\/gmt136","volume":"462","author":"P Ren","year":"2014","unstructured":"Ren P, Sheng Z, Wang Y, Yi X, Zhou Q, Zhou J, Xiang S, Hu X, Zhang J (2014) Rnf20 promotes the polyubiquitination and proteasome-dependent degradation of Ap-2alpha protein. Acta Biochim Biophys Sin (Shanghai) 462:136\u2013140. https:\/\/doi.org\/10.1093\/abbs\/gmt136","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"4896_CR21","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00265-17","author":"JH Lee","year":"2017","unstructured":"Lee JH, Jeon YG, Lee KH, Lee HW, Park J, Jang H, Kang M, Lee HS, Cho HJ, Nam DH, Kwak C, Kim JB (2017) Rnf20 suppresses tumorigenesis by inhibiting the Srebp1c-Pttg1 axis in kidney cancer. Mol Cell Biol. https:\/\/doi.org\/10.1128\/MCB.00265-17","journal-title":"Mol Cell Biol"},{"key":"4896_CR22","doi-asserted-by":"publisher","first-page":"20","DOI":"10.2337\/db19-0508","volume":"691","author":"YG Jeon","year":"2020","unstructured":"Jeon YG, Lee JH, Ji Y, Sohn JH, Lee D, Kim DW, Yoon SG, Shin KC, Park J, Seong JK, Cho JY, Choe SS, Kim JB (2020) Rnf20 functions as a transcriptional coactivator for ppargamma by promoting Ncor1 degradation in adipocytes. Diabetes 691:20\u201334. https:\/\/doi.org\/10.2337\/db19-0508","journal-title":"Diabetes"},{"key":"4896_CR23","doi-asserted-by":"publisher","first-page":"e13131","DOI":"10.1111\/cpr.13131","volume":"5412","author":"Y Zhao","year":"2021","unstructured":"Zhao Y, Pan J, Cao C, Liang X, Yang S, Liu L, Tao C, Zhao J, Wang Y (2021) Rnf20 affects porcine adipocyte differentiation via regulation of mitotic clonal expansion. Cell Prolif 5412:e13131. https:\/\/doi.org\/10.1111\/cpr.13131","journal-title":"Cell Prolif"},{"key":"4896_CR24","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1007\/s13238-020-00770-2","volume":"126","author":"X Liang","year":"2021","unstructured":"Liang X, Tao C, Pan J, Zhang L, Liu L, Zhao Y, Fan Y, Cao C, Liu J, Zhang J, Lam SM, Shui G, Jin W, Li W, Zhao J, Li K, Wang Y (2021) Rnf20 deficiency in adipocyte impairs adipose tissue development and thermogenesis. Protein Cell 126:475\u2013492. https:\/\/doi.org\/10.1007\/s13238-020-00770-2","journal-title":"Protein Cell"},{"key":"4896_CR25","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1016\/j.bbalip.2019.06.017","volume":"186410","author":"J Pan","year":"2019","unstructured":"Pan J, Tao C, Cao C, Zheng Q, Lam SM, Shui G, Liu X, Li K, Zhao J, Wang Y (2019) Adipose lipidomics and Rna-Seq analysis revealed the enhanced mitochondrial function in Ucp1 knock-in pigs. Biochim Biophys Acta Mol Cell Biol Lipids 186410:1375\u20131383. https:\/\/doi.org\/10.1016\/j.bbalip.2019.06.017","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"key":"4896_CR26","doi-asserted-by":"publisher","first-page":"101456","DOI":"10.1016\/j.molmet.2022.101456","volume":"59","author":"AS Pereyra","year":"2022","unstructured":"Pereyra AS, Lin CT, Sanchez DM, Laskin J, Spangenburg EE, Neufer PD, Fisher-Wellman K, Ellis JM (2022) Skeletal muscle undergoes fiber type metabolic switch without myosin heavy chain switch in response to defective fatty acid oxidation. Mol Metab. 59:101456. https:\/\/doi.org\/10.1016\/j.molmet.2022.101456","journal-title":"Mol Metab."},{"key":"4896_CR27","doi-asserted-by":"publisher","first-page":"2753","DOI":"10.1038\/s41467-023-38003-9","volume":"141","author":"L Wang","year":"2023","unstructured":"Wang L, Zhou M (2023) Structure of a eukaryotic cholinephosphotransferase-1 reveals mechanisms of substrate recognition and catalysis. Nat Commun 141:2753. https:\/\/doi.org\/10.1038\/s41467-023-38003-9","journal-title":"Nat Commun"},{"key":"4896_CR28","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1038\/ncb1101-1014","volume":"311","author":"SC Bodine","year":"2001","unstructured":"Bodine SC, Stitt TN, Gonzalez M, Kline WO, Stover GL, Bauerlein R, Zlotchenko E, Scrimgeour A, Lawrence JC, Glass DJ, Yancopoulos GD (2001) Akt\/Mtor pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo. Nat Cell Biol 311:1014\u20131019. https:\/\/doi.org\/10.1038\/ncb1101-1014","journal-title":"Nat Cell Biol"},{"key":"4896_CR29","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1038\/ncb1101-1009","volume":"311","author":"C Rommel","year":"2001","unstructured":"Rommel C, Bodine SC, Clarke BA, Rossman R, Nunez L, Stitt TN, Yancopoulos GD, Glass DJ (2001) Mediation of Igf-1-induced skeletal myotube hypertrophy by Pi(3)K\/Akt\/Mtor and Pi(3)K\/Akt\/Gsk3 pathways. Nat Cell Biol 311:1009\u20131013. https:\/\/doi.org\/10.1038\/ncb1101-1009","journal-title":"Nat Cell Biol"},{"key":"4896_CR30","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.meatsci.2007.12.020","volume":"802","author":"YC Ryu","year":"2008","unstructured":"Ryu YC, Choi YM, Lee SH, Shin HG, Choe JH, Kim JM, Hong KC, Kim BC (2008) Comparing the histochemical characteristics and meat quality traits of different pig breeds. Meat Sci 802:363\u2013369. https:\/\/doi.org\/10.1016\/j.meatsci.2007.12.020","journal-title":"Meat Sci"},{"key":"4896_CR31","doi-asserted-by":"publisher","first-page":"2990","DOI":"10.1096\/fj.07-097600","volume":"228","author":"H Shi","year":"2008","unstructured":"Shi H, Scheffler JM, Pleitner JM, Zeng C, Park S, Hannon KM, Grant AL, Gerrard DE (2008) Modulation of skeletal muscle fiber type by mitogen-activated protein kinase signaling. FASEB J 228:2990\u20133000. https:\/\/doi.org\/10.1096\/fj.07-097600","journal-title":"FASEB J"},{"key":"4896_CR32","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1097\/MCO.0b013e3282fb7b76","volume":"113","author":"HJ Koh","year":"2008","unstructured":"Koh HJ, Brandauer J, Goodyear LJ (2008) Lkb1 and Ampk and the regulation of skeletal muscle metabolism. Curr Opin Clin Nutr Metab Care 113:227\u2013232. https:\/\/doi.org\/10.1097\/MCO.0b013e3282fb7b76","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"4896_CR33","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1007\/s00125-002-0873-y","volume":"459","author":"KN Frayn","year":"2002","unstructured":"Frayn KN (2002) Adipose tissue as a buffer for daily lipid flux. Diabetologia 459:1201\u20131210. https:\/\/doi.org\/10.1007\/s00125-002-0873-y","journal-title":"Diabetologia"},{"key":"4896_CR34","doi-asserted-by":"publisher","first-page":"1805","DOI":"10.1194\/jlr.M082008","volume":"5910","author":"K D'Souza","year":"2018","unstructured":"D\u2019Souza K, Nzirorera C, Cowie AM, Varghese GP, Trivedi P, Eichmann TO, Biswas D, Touaibia M, Morris AJ, Aidinis V, Kane DA, Pulinilkunnil T, Kienesberger PC (2018) Autotaxin-Lpa signaling contributes to obesity-induced insulin resistance in muscle and impairs mitochondrial metabolism. J Lipid Res 5910:1805\u20131817. https:\/\/doi.org\/10.1194\/jlr.M082008","journal-title":"J Lipid Res"},{"key":"4896_CR35","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1016\/j.cell.2008.07.048","volume":"1346","author":"H Cao","year":"2008","unstructured":"Cao H, Gerhold K, Mayers JR, Wiest MM, Watkins SM, Hotamisligil GS (2008) Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism. Cell 1346:933\u2013944. https:\/\/doi.org\/10.1016\/j.cell.2008.07.048","journal-title":"Cell"},{"key":"4896_CR36","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1038\/nm.4297","volume":"235","author":"MD Lynes","year":"2017","unstructured":"Lynes MD, Leiria LO, Lundh M, Bartelt A, Shamsi F, Huang TL, Takahashi H, Hirshman MF, Schlein C, Lee A, Baer LA, May FJ, Gao F, Narain NR, Chen EY, Kiebish MA, Cypess AM, Bluher M, Goodyear LJ, Hotamisligil GS, Stanford KI, Tseng YH (2017) The cold-induced lipokine 12,13-dihome promotes fatty acid transport into brown adipose tissue. Nat Med 235:631\u2013637. https:\/\/doi.org\/10.1038\/nm.4297","journal-title":"Nat Med"},{"key":"4896_CR37","doi-asserted-by":"publisher","first-page":"3224","DOI":"10.1021\/acs.jmedchem.8b00029","volume":"617","author":"H Lin","year":"2018","unstructured":"Lin H, Long JZ, Roche AM, Svensson KJ, Dou FY, Chang MR, Strutzenberg T, Ruiz C, Cameron MD, Novick SJ, Berdan CA, Louie SM, Nomura DK, Spiegelman BM, Griffin PR, Kamenecka TM (2018) Discovery of hydrolysis-resistant isoindoline N-acyl amino acid analogues that stimulate mitochondrial respiration. J Med Chem 617:3224\u20133230. https:\/\/doi.org\/10.1021\/acs.jmedchem.8b00029","journal-title":"J Med Chem"},{"key":"4896_CR38","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1007\/s11306-013-0590-1","volume":"103","author":"N Schafer","year":"2014","unstructured":"Schafer N, Yu Z, Wagener A, Millrose MK, Reissmann M, Bortfeldt R, Dieterich C, Adamski J, Wang-Sattler R, Illig T, Brockmann GA (2014) Changes in metabolite profiles caused by genetically determined obesity in mice. Metabolomics 103:461\u2013472. https:\/\/doi.org\/10.1007\/s11306-013-0590-1","journal-title":"Metabolomics"},{"key":"4896_CR39","doi-asserted-by":"publisher","first-page":"e21867","DOI":"10.1096\/fj.202101104R","volume":"3510","author":"PJ Ferrara","year":"2021","unstructured":"Ferrara PJ, Verkerke ARP, Maschek JA, Shahtout JL, Siripoksup P, Eshima H, Johnson JM, Petrocelli JJ, Mahmassani ZS, Green TD, McClung JM, Cox JE, Drummond MJ, Funai K (2021) Low lysophosphatidylcholine induces skeletal muscle myopathy that is aggravated by high-fat diet feeding. FASEB J 3510:e21867. https:\/\/doi.org\/10.1096\/fj.202101104R","journal-title":"FASEB J"},{"key":"4896_CR40","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1007\/s11306-017-1185-z","volume":"135","author":"MR Boon","year":"2017","unstructured":"Boon MR, Bakker LEH, Prehn C, Adamski J, Vosselman MJ, Jazet IM, Arias-Bouda LMP, van Lichtenbelt WDM, van Dijk KW, Rensen PCN, Mook-Kanamori DO (2017) Lysopc-Acyl C16:0 is associated with brown adipose tissue activity in men. Metabolomics 135:48. https:\/\/doi.org\/10.1007\/s11306-017-1185-z","journal-title":"Metabolomics"},{"key":"4896_CR41","first-page":"190","volume":"1052","author":"G Sekas","year":"1985","unstructured":"Sekas G, Patton GM, Lincoln EC, Robins SJ (1985) Origin of plasma lysophosphatidylcholine: evidence for direct hepatic secretion in the rat. J Lab Clin Med 1052:190\u2013194","journal-title":"J Lab Clin Med"},{"key":"4896_CR42","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1097\/MCO.0b013e3283600d46","volume":"163","author":"MG Mehedint","year":"2013","unstructured":"Mehedint MG, Zeisel SH (2013) Choline\u2019s role in maintaining liver function: new evidence for epigenetic mechanisms. Curr Opin Clin Nutr Metab Care 163:339\u2013345. https:\/\/doi.org\/10.1097\/MCO.0b013e3283600d46","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"4896_CR43","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1194\/jlr.M011395","volume":"524","author":"L Liu","year":"2011","unstructured":"Liu L, Yu S, Khan RS, Ables GP, Bharadwaj KG, Hu Y, Huggins LA, Eriksson JW, Buckett LK, Turnbull AV, Ginsberg HN, Blaner WS, Huang LS, Goldberg IJ (2011) Dgat1 deficiency decreases Ppar expression and does not lead to lipotoxicity in cardiac and skeletal muscle. J Lipid Res 524:732\u2013744. https:\/\/doi.org\/10.1194\/jlr.M011395","journal-title":"J Lipid Res"},{"key":"4896_CR44","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1111\/tra.12608","volume":"1911","author":"C Schlegel","year":"2018","unstructured":"Schlegel C, Lapierre LA, Weis VG, Williams JA, Kaji I, Pinzon-Guzman C, Prasad N, Boone B, Jones A, Correa H, Levy SE, Han X, Wang M, Thomsen K, Acra S, Goldenring JR (2018) Reversible deficits in apical transporter trafficking associated with deficiency in diacylglycerol acyltransferase. Traffic 1911:879\u2013892. https:\/\/doi.org\/10.1111\/tra.12608","journal-title":"Traffic"},{"key":"4896_CR45","doi-asserted-by":"publisher","first-page":"2284","DOI":"10.2337\/db13-1502","volume":"637","author":"AM Hall","year":"2014","unstructured":"Hall AM, Soufi N, Chambers KT, Chen Z, Schweitzer GG, McCommis KS, Erion DM, Graham MJ, Su X, Finck BN (2014) Abrogating monoacylglycerol acyltransferase activity in liver improves glucose tolerance and hepatic insulin signaling in obese mice. Diabetes 637:2284\u20132296. https:\/\/doi.org\/10.2337\/db13-1502","journal-title":"Diabetes"},{"key":"4896_CR46","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/j.1440-1681.2008.05075.x","volume":"361","author":"MJ Watt","year":"2009","unstructured":"Watt MJ (2009) Storing up trouble: does accumulation of intramyocellular triglyceride protect skeletal muscle from insulin resistance? Clin Exp Pharmacol Physiol 361:5\u201311. https:\/\/doi.org\/10.1111\/j.1440-1681.2008.05075.x","journal-title":"Clin Exp Pharmacol Physiol"}],"container-title":["Cellular and Molecular Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-023-04896-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00018-023-04896-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-023-04896-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T17:15:47Z","timestamp":1694452547000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00018-023-04896-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,9]]},"references-count":46,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["4896"],"URL":"https:\/\/doi.org\/10.1007\/s00018-023-04896-4","relation":{},"ISSN":["1420-682X","1420-9071"],"issn-type":[{"value":"1420-682X","type":"print"},{"value":"1420-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,9]]},"assertion":[{"value":"1 March 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 July 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 July 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 August 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was performed in line with the principles of Animal Research Panel of the Committee on Research Practice. Approval was granted by Animal Ethics Committee of the Institute of Animal Science (No. IOZ20190077).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Human experiments are not involved in this article.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}],"article-number":"243"}}