{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T22:32:15Z","timestamp":1779921135536,"version":"3.53.1"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T00:00:00Z","timestamp":1701820800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T00:00:00Z","timestamp":1701820800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Ministry of Education Singapore","award":["T2EP30221-0012"],"award-info":[{"award-number":["T2EP30221-0012"]}]},{"DOI":"10.13039\/501100001459","name":"Singapore Ministry of Education","doi-asserted-by":"crossref","award":["T2EP30123-0014"],"award-info":[{"award-number":["T2EP30123-0014"]}],"id":[{"id":"10.13039\/501100001459","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell. Mol. Life Sci."],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1007\/s00018-023-05048-4","type":"journal-article","created":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T08:02:31Z","timestamp":1701849751000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Mfsd7b facilitates choline transport and missense mutations affect choline transport function"],"prefix":"10.1007","volume":"81","author":[{"given":"Hoa Thi Thuy","family":"Ha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viresh Krishnan","family":"Sukumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan Wei Bao","family":"Chua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dat T.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toan Q.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina Hsiu Kim","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amaury","family":"Cazenave-Gassiot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9857-2239","authenticated-orcid":false,"given":"Long N.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,12,6]]},"reference":[{"key":"5048_CR1","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1182\/blood.V95.3.1093.003k01_1093_1099","volume":"95","author":"JG Quigley","year":"2000","unstructured":"Quigley JG, Burns CC, Anderson MM, Lynch ED, Sabo KM, Overbaugh J, Abkowitz JL (2000) Cloning of the cellular receptor for feline leukemia virus subgroup C (FeLV-C), a retrovirus that induces red cell aplasia. Blood 95:1093\u20131099","journal-title":"Blood"},{"key":"5048_CR2","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/j.cell.2004.08.014","volume":"118","author":"JG Quigley","year":"2004","unstructured":"Quigley JG, Yang Z, Worthington MT, Phillips JD, Sabo KM, Sabath DE, Berg CL, Sassa S, Wood BL, Abkowitz JL (2004) Identification of a human heme exporter that is essential for erythropoiesis. Cell 118:757\u2013766","journal-title":"Cell"},{"key":"5048_CR3","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/j.ajhg.2010.10.013","volume":"87","author":"AM Rajadhyaksha","year":"2010","unstructured":"Rajadhyaksha AM, Elemento O, Puffenberger EG, Schierberl KC, Xiang JZ, Putorti ML, Berciano J, Poulin C, Brais B, Michaelides M, Weleber RG, Higgins JJ (2010) Mutations in FLVCR1 cause posterior column ataxia and retinitis pigmentosa. Am J Hum Genet 87:643\u2013654","journal-title":"Am J Hum Genet"},{"key":"5048_CR4","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/s10048-010-0271-4","volume":"12","author":"H Ishiura","year":"2011","unstructured":"Ishiura H, Fukuda Y, Mitsui J, Nakahara Y, Ahsan B, Takahashi Y, Ichikawa Y, Goto J, Sakai T, Tsuji S (2011) Posterior column ataxia with retinitis pigmentosa in a Japanese family with a novel mutation in FLVCR1. Neurogenetics 12:117\u2013121","journal-title":"Neurogenetics"},{"key":"5048_CR5","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.bcmd.2012.03.004","volume":"49","author":"I Yanatori","year":"2012","unstructured":"Yanatori I, Yasui Y, Miura K, Kishi F (2012) Mutations of FLVCR1 in posterior column ataxia and retinitis pigmentosa result in the loss of heme export activity. Blood Cells Mol Dis 49:60\u201366","journal-title":"Blood Cells Mol Dis"},{"key":"5048_CR6","doi-asserted-by":"publisher","first-page":"e1006461","DOI":"10.1371\/journal.pgen.1006461","volume":"12","author":"D Chiabrando","year":"2016","unstructured":"Chiabrando D, Castori M, di Rocco M, Ungelenk M, Giesselmann S, Di Capua M, Madeo A, Grammatico P, Bartsch S, Hubner CA, Altruda F, Silengo L, Tolosano E, Kurth I (2016) Mutations in the heme exporter FLVCR1 cause sensory neurodegeneration with loss of pain perception. PLoS Genet 12:e1006461","journal-title":"PLoS Genet"},{"key":"5048_CR7","doi-asserted-by":"publisher","first-page":"4569","DOI":"10.1172\/JCI62422","volume":"122","author":"D Chiabrando","year":"2012","unstructured":"Chiabrando D, Marro S, Mercurio S, Giorgi C, Petrillo S, Vinchi F, Fiorito V, Fagoonee S, Camporeale A, Turco E, Merlo GR, Silengo L, Altruda F, Pinton P, Tolosano E (2012) The mitochondrial heme exporter FLVCR1b mediates erythroid differentiation. J Clin Invest 122:4569\u20134579","journal-title":"J Clin Invest"},{"key":"5048_CR8","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1126\/science.1151133","volume":"319","author":"SB Keel","year":"2008","unstructured":"Keel SB, Doty RT, Yang Z, Quigley JG, Chen J, Knoblaugh S, Kingsley PD, De Domenico I, Vaughn MB, Kaplan J, Palis J, Abkowitz JL (2008) A heme export protein is required for red blood cell differentiation and iron homeostasis. Science 319:825\u2013828","journal-title":"Science"},{"key":"5048_CR9","doi-asserted-by":"publisher","first-page":"2903","DOI":"10.1182\/blood-2012-10-465104","volume":"122","author":"JC Byon","year":"2013","unstructured":"Byon JC, Chen J, Doty RT, Abkowitz JL (2013) FLVCR is necessary for erythroid maturation, may contribute to platelet maturation, but is dispensable for normal hematopoietic stem cell function. Blood 122:2903\u20132910","journal-title":"Blood"},{"key":"5048_CR10","doi-asserted-by":"publisher","first-page":"4681","DOI":"10.1172\/JCI83054","volume":"125","author":"RT Doty","year":"2015","unstructured":"Doty RT, Phelps SR, Shadle C, Sanchez-Bonilla M, Keel SB, Abkowitz JL (2015) Coordinate expression of heme and globin is essential for effective erythropoiesis. J Clin Invest 125:4681\u20134691","journal-title":"J Clin Invest"},{"key":"5048_CR11","doi-asserted-by":"publisher","first-page":"720","DOI":"10.3324\/haematol.2014.114488","volume":"100","author":"S Mercurio","year":"2015","unstructured":"Mercurio S, Petrillo S, Chiabrando D, Bassi ZI, Gays D, Camporeale A, Vacaru A, Miniscalco B, Valperga G, Silengo L, Altruda F, Baron MH, Santoro MM, Tolosano E (2015) The heme exporter Flvcr1 regulates expansion and differentiation of committed erythroid progenitors by controlling intracellular heme accumulation. Haematologica 100:720\u2013729","journal-title":"Haematologica"},{"key":"5048_CR12","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1038\/s41418-017-0001-7","volume":"25","author":"S Petrillo","year":"2018","unstructured":"Petrillo S, Chiabrando D, Genova T, Fiorito V, Ingoglia G, Vinchi F, Mussano F, Carossa S, Silengo L, Altruda F, Merlo GR, Munaron L, Tolosano E (2018) Heme accumulation in endothelial cells impairs angiogenesis by triggering paraptosis. Cell Death Differ 25:573\u2013588","journal-title":"Cell Death Differ"},{"key":"5048_CR13","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1053\/j.gastro.2014.01.053","volume":"146","author":"F Vinchi","year":"2014","unstructured":"Vinchi F, Ingoglia G, Chiabrando D, Mercurio S, Turco E, Silengo L, Altruda F, Tolosano E (2014) Heme exporter FLVCR1a regulates heme synthesis and degradation and controls activity of cytochromes P450. Gastroenterology 146:1325\u20131338","journal-title":"Gastroenterology"},{"key":"5048_CR14","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1089\/ars.2014.6216","volume":"23","author":"V Fiorito","year":"2015","unstructured":"Fiorito V, Forni M, Silengo L, Altruda F, Tolosano E (2015) Crucial role of FLVCR1a in the maintenance of intestinal heme homeostasis. Antioxid Redox Signal 23:1410\u20131423","journal-title":"Antioxid Redox Signal"},{"key":"5048_CR15","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1016\/j.cmet.2023.02.014","volume":"35","author":"M Tsuchiya","year":"2023","unstructured":"Tsuchiya M, Tachibana N, Nagao K, Tamura T, Hamachi I (2023) Organelle-selective click labeling coupled with flow cytometry allows pooled CRISPR screening of genes involved in phosphatidylcholine metabolism. Cell Metab 35:1072-1083 e1079","journal-title":"Cell Metab"},{"key":"5048_CR16","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1016\/j.cmet.2023.04.003","volume":"35","author":"TC Kenny","year":"2023","unstructured":"Kenny TC, Khan A, Son Y, Yue L, Heissel S, Sharma A, Pasolli HA, Liu Y, Gamazon ER, Alwaseem H, Hite RK, Birsoy K (2023) Integrative genetic analysis identifies FLVCR1 as a plasma-membrane choline transporter in mammals. Cell Metab 35:1057-1071 e1012","journal-title":"Cell Metab"},{"key":"5048_CR17","doi-asserted-by":"publisher","first-page":"3466","DOI":"10.1182\/blood-2014-01-548305","volume":"123","author":"X An","year":"2014","unstructured":"An X, Schulz VP, Li J, Wu K, Liu J, Xue F, Hu J, Mohandas N, Gallagher PG (2014) Global transcriptome analyses of human and murine terminal erythroid differentiation. Blood 123:3466\u20133477","journal-title":"Blood"},{"key":"5048_CR18","doi-asserted-by":"publisher","first-page":"109252","DOI":"10.1016\/j.celrep.2021.109252","volume":"35","author":"V Fiorito","year":"2021","unstructured":"Fiorito V, Allocco AL, Petrillo S, Gazzano E, Torretta S, Marchi S, Destefanis F, Pacelli C, Audrito V, Provero P, Medico E, Chiabrando D, Porporato PE, Cancelliere C, Bardelli A, Trusolino L, Capitanio N, Deaglio S, Altruda F, Pinton P, Cardaci S, Riganti C, Tolosano E (2021) The heme synthesis-export system regulates the tricarboxylic acid cycle flux and oxidative phosphorylation. Cell Rep 35:109252","journal-title":"Cell Rep"},{"key":"5048_CR19","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1172\/JCI4165","volume":"103","author":"A Yachie","year":"1999","unstructured":"Yachie A, Niida Y, Wada T, Igarashi N, Kaneda H, Toma T, Ohta K, Kasahara Y, Koizumi S (1999) Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency. J Clin Invest 103:129\u2013135","journal-title":"J Clin Invest"},{"key":"5048_CR20","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1097\/MPH.0b013e3181fd2aae","volume":"33","author":"N Radhakrishnan","year":"2011","unstructured":"Radhakrishnan N, Yadav SP, Sachdeva A, Pruthi PK, Sawhney S, Piplani T, Wada T, Yachie A (2011) Human heme oxygenase-1 deficiency presenting with hemolysis, nephritis, and asplenia. J Pediatr Hematol Oncol 33:74\u201378","journal-title":"J Pediatr Hematol Oncol"},{"key":"5048_CR21","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1186\/s12969-020-00474-1","volume":"18","author":"AS Chau","year":"2020","unstructured":"Chau AS, Cole BL, Debley JS, Nanda K, Rosen ABI, Bamshad MJ, Nickerson DA, Torgerson TR, Allenspach EJ (2020) Heme oxygenase-1 deficiency presenting with interstitial lung disease and hemophagocytic flares. Pediatr Rheumatol Online J 18:80","journal-title":"Pediatr Rheumatol Online J"},{"key":"5048_CR22","doi-asserted-by":"publisher","first-page":"10919","DOI":"10.1073\/pnas.94.20.10919","volume":"94","author":"KD Poss","year":"1997","unstructured":"Poss KD, Tonegawa S (1997) Heme oxygenase 1 is required for mammalian iron reutilization. Proc Natl Acad Sci USA 94:10919\u201310924","journal-title":"Proc Natl Acad Sci USA"},{"key":"5048_CR23","doi-asserted-by":"publisher","first-page":"17877","DOI":"10.1074\/jbc.REV120.013529","volume":"295","author":"M Tavasoli","year":"2020","unstructured":"Tavasoli M, Lahire S, Reid T, Brodovsky M, McMaster CR (2020) Genetic diseases of the Kennedy pathways for membrane synthesis. J Biol Chem 295:17877\u201317886","journal-title":"J Biol Chem"},{"key":"5048_CR24","doi-asserted-by":"publisher","first-page":"40","DOI":"10.3389\/fnmol.2017.00040","volume":"10","author":"P Choudhary","year":"2017","unstructured":"Choudhary P, Armstrong EJ, Jorgensen CC, Piotrowski M, Barthmes M, Torella R, Johnston SE, Maruyama Y, Janiszewski JS, Storer RI, Skerratt SE, Benn CL (2017) Discovery of compounds that positively modulate the high affinity choline transporter. Front Mol Neurosci 10:40","journal-title":"Front Mol Neurosci"}],"container-title":["Cellular and Molecular Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-023-05048-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00018-023-05048-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-023-05048-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T08:05:50Z","timestamp":1701849950000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00018-023-05048-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,6]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["5048"],"URL":"https:\/\/doi.org\/10.1007\/s00018-023-05048-4","relation":{},"ISSN":["1420-682X","1420-9071"],"issn-type":[{"value":"1420-682X","type":"print"},{"value":"1420-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,6]]},"assertion":[{"value":"15 July 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 November 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 November 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 December 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors declare that there is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"3"}}