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After exposure to conditioned medium (CM) from HTR-8\/SVneo\n                      <jats:sup>shNC<\/jats:sup>\n                      cells, hVSMCs exhibited a rounded morphology, indicative of dedifferentiation, while CM-HTR-8\/SVneo\n                      <jats:sup>shDAB2<\/jats:sup>\n                      cells displayed a spindle-like morphology. Furthermore, the PDC model demonstrated that CM-HTR-8\/SVneo\n                      <jats:sup>shDAB2<\/jats:sup>\n                      was less conducive to vascular remodeling. Further in-depth mechanistic investigations revealed that C-X-C motif chemokine ligand 8 (CXCL8, also known as IL8) is a pivotal regulator governing the dedifferentiation of dVSMC. DAB2 expression in EVTs is critical for orchestrating the phenotypic transition and motility of dVSMC. These processes may be intricately linked to the CXCL8\/PI3K\/AKT pathway, underscoring its central role in intricate SPA remodeling.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1007\/s00018-024-05212-4","type":"journal-article","created":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T09:01:42Z","timestamp":1712998902000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Identification of the role of DAB2 and CXCL8 in uterine spiral artery remodeling in early-onset preeclampsia"],"prefix":"10.1007","volume":"81","author":[{"given":"Yu","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shifeng","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingying","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minshan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siying","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaowei","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dunjin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9498-1684","authenticated-orcid":false,"given":"Jingsi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,13]]},"reference":[{"key":"5212_CR1","volume":"366","author":"JB Graham","year":"2019","unstructured":"Graham JB, Christopher WR, James MR, Ashley M (2019) Pre-eclampsia: pathophysiology and clinical implications. 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