{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T23:58:09Z","timestamp":1787356689537,"version":"build-2736575974"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,5,25]],"date-time":"2024-05-25T00:00:00Z","timestamp":1716595200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,5,25]],"date-time":"2024-05-25T00:00:00Z","timestamp":1716595200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81602301"],"award-info":[{"award-number":["81602301"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972489"],"award-info":[{"award-number":["81972489"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2021MH235"],"award-info":[{"award-number":["ZR2021MH235"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shandong province college science and technology plan project","award":["J17KA254"],"award-info":[{"award-number":["J17KA254"]}]},{"name":"Clinical Research Center of Affiliated Hospital of Weifang Medical University","award":["2021wyfylcyj01"],"award-info":[{"award-number":["2021wyfylcyj01"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell. Mol. Life Sci."],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ovarian endometriosis is a common gynecological disease, and one of its most significant symptoms is infertility. In patients with endometriosis, defects in endometrial decidualization lead to impaired endometrial receptivity and embryo implantation, thus affecting early pregnancy and women\u2019s desire to have children. However, the mechanisms underlying the development of endometriosis and its associated defective decidualization are unclear. We find that NEK2 expression is increased in the ectopic and eutopic endometrium of patients with endometriosis. Meanwhile, NEK2 interacts with FOXO1 and phosphorylates FOXO1 at Ser184, inhibiting the stability of the FOXO1 protein. Importantly, NEK2-mediated phosphorylation of FOXO1 at Ser184 promotes cell proliferation, migration, invasion and impairs decidualization. Furthermore, INH1, an inhibitor of NEK2, inhibits the growth of ectopic lesions in mouse models of endometriosis and promotes endometrial decidualization in mouse models of artificially induced decidualization. Taken together, these findings indicate that NEK2 regulates the development of endometriosis and associated disorders of decidualization through the phosphorylation of FOXO1, providing a new therapeutic target for its treatment.<\/jats:p>","DOI":"10.1007\/s00018-024-05270-8","type":"journal-article","created":{"date-parts":[[2024,5,25]],"date-time":"2024-05-25T07:01:46Z","timestamp":1716620506000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["NEK2 promotes the development of ovarian endometriosis and impairs decidualization by phosphorylating FOXO1"],"prefix":"10.1007","volume":"81","author":[{"given":"Mengxue","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangyuan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shucai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aifang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengyun","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chune","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9927-3057","authenticated-orcid":false,"given":"Tingting","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,25]]},"reference":[{"key":"5270_CR1","doi-asserted-by":"crossref","unstructured":"Ye L, Whitaker LHR, Mawson RL, Hickey M (2022) Endometr BMJ 379, e068950","DOI":"10.1136\/bmj-2021-068950"},{"key":"5270_CR2","doi-asserted-by":"publisher","first-page":"e070750","DOI":"10.1136\/bmj-2022-070750","volume":"379","author":"AW Horne","year":"2022","unstructured":"Horne AW, Missmer SA (2022) Pathophysiology, diagnosis, and management of endometriosis. BMJ 379:e070750","journal-title":"BMJ"},{"key":"5270_CR3","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1093\/humupd\/8.6.591","volume":"8","author":"C Chapron","year":"2002","unstructured":"Chapron C, Vercellini P, Barakat H, Vieira M, Dubuisson JB (2002) Management of ovarian endometriomas. Hum Reprod Update 8:591\u2013597","journal-title":"Hum Reprod Update"},{"key":"5270_CR4","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1038\/s41574-019-0245-z","volume":"15","author":"C Chapron","year":"2019","unstructured":"Chapron C, Marcellin L, Borghese B, Santulli P (2019) Rethinking mechanisms, diagnosis and management of endometriosis. Nat Rev Endocrinol 15:666\u2013682","journal-title":"Nat Rev Endocrinol"},{"key":"5270_CR5","doi-asserted-by":"crossref","unstructured":"Zondervan KT, Becker CM, Koga K, Missmer SA, Taylor RN, Vigan\u00f2 P (2018) Endometriosis. Nat Reviews Disease Primers 4","DOI":"10.1038\/s41572-018-0008-5"},{"key":"5270_CR6","doi-asserted-by":"publisher","first-page":"g1752","DOI":"10.1136\/bmj.g1752","volume":"348","author":"M Hickey","year":"2014","unstructured":"Hickey M, Ballard K, Farquhar C (2014) Endometriosis. BMJ 348:g1752","journal-title":"BMJ"},{"key":"5270_CR7","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.fertnstert.2017.05.031","volume":"108","author":"BA Lessey","year":"2017","unstructured":"Lessey BA, Kim JJ (2017) Endometrial receptivity in the eutopic endometrium of women with endometriosis: it is affected, and let me show you why. Fertil Steril 108:19\u201327","journal-title":"Fertil Steril"},{"key":"5270_CR8","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1016\/j.mam.2012.12.011","volume":"34","author":"S Zhang","year":"2013","unstructured":"Zhang S, Lin H, Kong S, Wang S, Wang H, Wang H, Armant DR (2013) Physiological and molecular determinants of embryo implantation. Mol Aspects Med 34:939\u2013980","journal-title":"Mol Aspects Med"},{"key":"5270_CR9","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1056\/NEJMra0804690","volume":"360","author":"SE Bulun","year":"2009","unstructured":"Bulun SE (2009) Endometriosis. N Engl J Med 360:268\u2013279","journal-title":"Endometr N Engl J Med"},{"key":"5270_CR10","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1210\/er.2014-1045","volume":"35","author":"B Gellersen","year":"2014","unstructured":"Gellersen B, Brosens JJ (2014) Cyclic decidualization of the human endometrium in reproductive health and failure. Endocr Rev 35:851\u2013905","journal-title":"Endocr Rev"},{"key":"5270_CR11","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.1007\/s00018-019-03395-9","volume":"77","author":"H Liu","year":"2020","unstructured":"Liu H, Huang X, Mor G, Liao A (2020) Epigenetic modifications working in the decidualization and endometrial receptivity. Cell Mol Life Sci 77:2091\u20132101","journal-title":"Cell Mol Life Sci"},{"key":"5270_CR12","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1038\/s41467-022-28608-x","volume":"13","author":"JY Yoo","year":"2022","unstructured":"Yoo JY, Kim TH, Shin JH, Marquardt RM, Muller U, Fazleabas AT, Young SL, Lessey BA, Yoon HG, Jeong JW (2022) Loss of MIG-6 results in endometrial progesterone resistance via ERBB2. Nat Commun 13:1101","journal-title":"Nat Commun"},{"key":"5270_CR13","doi-asserted-by":"crossref","unstructured":"Kim TH, Yoo JY, Choi KC, Shin JH, Leach RE, Fazleabas AT, Young SL, Lessey BA, Yoon HG, Jeong JW (2019) Loss of HDAC3 results in nonreceptive endometrium and female infertility. Sci Transl Med 11","DOI":"10.1126\/scitranslmed.aaf7533"},{"key":"5270_CR14","unstructured":"Adiguzel D, Celik-Ozenci C, Kajihara T, Brosens JJ, Ishihara O (2021) FoxO1 is a cell-specific core transcription factor for endometrial remodeling and homeostasis during menstrual cycle and early pregnancy. Hum Reprod UpdateMedical Mol Morphology 27:570\u2013583"},{"key":"5270_CR15","doi-asserted-by":"crossref","unstructured":"Thackray VG (2014) Fox tales: regulation of gonadotropin gene expression by forkhead transcription factors. Mol Cell Endocrinol 385, 62\u201370","DOI":"10.1016\/j.mce.2013.09.034"},{"key":"5270_CR16","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1161\/CIRCRESAHA.120.316738","volume":"128","author":"ID Kyriazis","year":"2021","unstructured":"Kyriazis ID, Hoffman M, Gaignebet L, Lucchese AM, Markopoulou E, Palioura D, Wang C, Bannister TD, Christofidou-Solomidou M, Oka SI et al (2021) KLF5 is Induced by FOXO1 and causes oxidative stress and Diabetic Cardiomyopathy. Circ Res 128:335\u2013357","journal-title":"Circ Res"},{"key":"5270_CR17","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1111\/exd.13775","volume":"27","author":"G Shi","year":"2018","unstructured":"Shi G, Liao PY, Cai XL, Pi XX, Zhang MF, Li SJ, Quan JH, Fan YM (2018) FoxO1 enhances differentiation and apoptosis in human primary keratinocytes. Exp Dermatol 27:1254\u20131260","journal-title":"Exp Dermatol"},{"key":"5270_CR18","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1016\/j.jcmgh.2020.10.006","volume":"11","author":"L Zhang","year":"2021","unstructured":"Zhang L, Zhang Z, Li C, Zhu T, Gao J, Zhou H, Zheng Y, Chang Q, Wang M, Wu J et al (2021) S100A11 promotes liver steatosis via FOXO1-Mediated autophagy and Lipogenesis. Cell Mol Gastroenterol Hepatol 11:697\u2013724","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"5270_CR19","doi-asserted-by":"publisher","first-page":"2530","DOI":"10.3389\/fimmu.2019.02530","volume":"10","author":"DT Graves","year":"2019","unstructured":"Graves DT, Milovanova TN (2019) Mucosal immunity and the FOXO1 transcription factors. Front Immunol 10:2530","journal-title":"Front Immunol"},{"key":"5270_CR20","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1093\/biolre\/ioac041","volume":"106","author":"N Kang","year":"2022","unstructured":"Kang N, Shan H, Wang J, Mei J, Jiang Y, Zhou J, Huang C, Zhang H, Zhang M, Zhen X et al (2022) Calpain7 negatively regulates human endometrial stromal cell decidualization in EMs by promoting FoxO1 nuclear exclusion via hydrolyzing AKT1. Biol Reprod 106:1112\u20131125","journal-title":"Biol Reprod"},{"key":"5270_CR21","doi-asserted-by":"publisher","first-page":"E433","DOI":"10.1210\/jc.2014-3720","volume":"100","author":"RW Su","year":"2015","unstructured":"Su RW, Strug MR, Joshi NR, Jeong JW, Miele L, Lessey BA, Young SL, Fazleabas AT (2015) Decreased notch pathway signaling in the endometrium of women with endometriosis impairs decidualization. J Clin Endocrinol Metab 100:E433\u2013442","journal-title":"J Clin Endocrinol Metab"},{"key":"5270_CR22","doi-asserted-by":"publisher","first-page":"E35","DOI":"10.1210\/jc.2011-1527","volume":"97","author":"X Yin","year":"2012","unstructured":"Yin X, Pavone ME, Lu Z, Wei J, Kim JJ (2012) Increased activation of the PI3K\/AKT pathway compromises decidualization of stromal cells from endometriosis. J Clin Endocrinol Metab 97:E35\u201343","journal-title":"J Clin Endocrinol Metab"},{"key":"5270_CR23","doi-asserted-by":"crossref","unstructured":"Bhansali RS, Rammohan M, Lee P, Laurent AP, Wen Q, Suraneni P, Yip BH, Tsai YC, Jenni S, Bornhauser B et al (2021) DYRK1A regulates B cell acute lymphoblastic leukemia through phosphorylation of FOXO1 and STAT3. J Clin Invest 131","DOI":"10.1172\/JCI135937"},{"key":"5270_CR24","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.canlet.2020.06.005","volume":"494","author":"H Yin","year":"2020","unstructured":"Yin H, Wang X, Zhang X, Zeng Y, Xu Q, Wang W, Zhou F, Zhou Y (2020) UBE2T promotes radiation resistance in non-small cell lung cancer via inducing epithelial-mesenchymal transition and the ubiquitination-mediated FOXO1 degradation. Cancer Lett 494:121\u2013131","journal-title":"Cancer Lett"},{"key":"5270_CR25","doi-asserted-by":"publisher","first-page":"e3088","DOI":"10.1038\/cddis.2017.467","volume":"8","author":"M Zhang","year":"2017","unstructured":"Zhang M, Zhang Q, Hu Y, Xu L, Jiang Y, Zhang C, Ding L, Jiang R, Sun J, Sun H et al (2017) miR-181a increases FoxO1 acetylation and promotes granulosa cell apoptosis via SIRT1 downregulation. Cell Death Dis 8:e3088","journal-title":"Cell Death Dis"},{"key":"5270_CR26","doi-asserted-by":"publisher","first-page":"8939","DOI":"10.7150\/thno.45178","volume":"10","author":"D Jian","year":"2020","unstructured":"Jian D, Wang Y, Jian L, Tang H, Rao L, Chen K, Jia Z, Zhang W, Liu Y, Chen X et al (2020) METTL14 aggravates endothelial inflammation and atherosclerosis by increasing FOXO1 N6-methyladeosine modifications. Theranostics 10:8939\u20138956","journal-title":"Theranostics"},{"key":"5270_CR27","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1080\/15384101.2016.1152430","volume":"15","author":"Y Fang","year":"2016","unstructured":"Fang Y, Zhang X (2016) Targeting NEK2 as a promising therapeutic approach for cancer treatment. Cell Cycle 15:895\u2013907","journal-title":"Cell Cycle"},{"key":"5270_CR28","first-page":"17","volume":"23","author":"NK Panchal","year":"2023","unstructured":"Panchal NK, Evan Prince S (2023) The NEK family of serine\/threonine kinases as a biomarker for cancer. Clin Exp Med 23:17\u201330","journal-title":"Clin Exp Med"},{"key":"5270_CR29","doi-asserted-by":"crossref","unstructured":"Zhang X, Huang X, Xu J, Li E, Lao M, Tang T, Zhang G, Guo C, Zhang X, Chen W et al (2021) NEK2 inhibition triggers anti-pancreatic cancer immunity by targeting PD-L1. Nature Communications 12","DOI":"10.1038\/s41467-021-24769-3"},{"key":"5270_CR30","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1186\/s12964-022-00898-0","volume":"20","author":"W Su","year":"2022","unstructured":"Su W, Hu H, Ding Q, Wang M, Zhu Y, Zhang Z, Geng Z, Lin S, Zhou P (2022) NEK2 promotes the migration and proliferation of ESCC via stabilization of YAP1 by phosphorylation at Thr-143. Cell Commun Signal 20:87","journal-title":"Cell Commun Signal"},{"key":"5270_CR31","doi-asserted-by":"publisher","first-page":"10666","DOI":"10.1073\/pnas.1806643115","volume":"115","author":"BK Choi","year":"2018","unstructured":"Choi BK, Dayaram T, Parikh N, Wilkins AD, Nagarajan M, Novikov IB, Bachman BJ, Jung SY, Haas PJ, Labrie JL et al (2018) Literature-based automated discovery of tumor suppressor p53 phosphorylation and inhibition by NEK2. Proc Natl Acad Sci U S A 115:10666\u201310671","journal-title":"Proc Natl Acad Sci U S A"},{"key":"5270_CR32","doi-asserted-by":"crossref","unstructured":"Au FKC, Hau BKT, Qi RZ (2020) Nek2-mediated GAS2L1 phosphorylation and centrosome-linker disassembly induce centrosome disjunction. J Cell Biol 219","DOI":"10.1083\/jcb.201909094"},{"key":"5270_CR33","doi-asserted-by":"publisher","first-page":"2334","DOI":"10.1210\/me.2007-0058","volume":"21","author":"M Takano","year":"2007","unstructured":"Takano M, Lu Z, Goto T, Fusi L, Higham J, Francis J, Withey A, Hardt J, Cloke B, Stavropoulou AV et al (2007) Transcriptional cross talk between the forkhead transcription factor forkhead box O1A and the progesterone receptor coordinates cell cycle regulation and differentiation in human endometrial stromal cells. Mol Endocrinol 21:2334\u20132349","journal-title":"Mol Endocrinol"},{"key":"5270_CR34","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s00018-022-04637-z","volume":"80","author":"Y Sun","year":"2022","unstructured":"Sun Y, Wang Q, Wang M, Sun F, Qiao P, Jiang A, Ren C, Yu Z, Yang T (2022) CHIP induces ubiquitination and degradation of HMGB1 to regulate glycolysis in ovarian endometriosis. Cell Mol Life Sci 80:13","journal-title":"Cell Mol Life Sci"},{"key":"5270_CR35","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1093\/humrep\/dev025","volume":"30","author":"D Ding","year":"2015","unstructured":"Ding D, Liu X, Duan J, Guo SW (2015) Platelets are an unindicted culprit in the development of endometriosis: clinical and experimental evidence. Hum Reprod 30:812\u2013832","journal-title":"Hum Reprod"},{"key":"5270_CR36","doi-asserted-by":"crossref","unstructured":"Wang M, Fan R, Jiang J, Sun F, Sun Y, Wang Q, Jiang A, Yu Z, Yang T (2023) PIM2 promotes the development of ovarian endometriosis by enhancing Glycolysis and fibrosis. Reprod Sci","DOI":"10.1007\/s43032-023-01208-w"},{"key":"5270_CR37","doi-asserted-by":"publisher","first-page":"8393","DOI":"10.1158\/0008-5472.CAN-08-1915","volume":"68","author":"G Wu","year":"2008","unstructured":"Wu G, Qiu XL, Zhou L, Zhu J, Chamberlin R, Lau J, Chen PL, Lee WH (2008) Small molecule targeting the Hec1\/Nek2 mitotic pathway suppresses tumor cell growth in culture and in animal. Cancer Res 68:8393\u20138399","journal-title":"Cancer Res"},{"key":"5270_CR38","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/j.fertnstert.2012.06.029","volume":"98","author":"RO Burney","year":"2012","unstructured":"Burney RO, Giudice LC (2012) Pathogenesis and pathophysiology of endometriosis. Fertil Steril 98:511\u2013519","journal-title":"Fertil Steril"},{"key":"5270_CR39","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1186\/s13046-020-01659-y","volume":"39","author":"T Xu","year":"2020","unstructured":"Xu T, Zeng Y, Shi L, Yang Q, Chen Y, Wu G, Li G, Xu S (2020) Targeting NEK2 impairs oncogenesis and radioresistance via inhibiting the Wnt1\/beta-catenin signaling pathway in cervical cancer. J Exp Clin Cancer Res 39:183","journal-title":"J Exp Clin Cancer Res"},{"key":"5270_CR40","doi-asserted-by":"publisher","first-page":"2193","DOI":"10.3892\/or.2016.5009","volume":"36","author":"S Wen","year":"2016","unstructured":"Wen S, Liu Y, Yang M, Yang K, Huang J, Feng D (2016) Increased NEK2 in hepatocellular carcinoma promotes cancer progression and drug resistance by promoting PP1\/Akt and wnt activation. Oncol Rep 36:2193\u20132199","journal-title":"Oncol Rep"},{"key":"5270_CR41","first-page":"2364","volume":"9","author":"Y Li","year":"2019","unstructured":"Li Y, Chen L, Feng L, Zhu M, Shen Q, Fang Y, Liu X, Zhang X (2019) NEK2 promotes proliferation, migration and tumor growth of gastric cancer cells via regulating KDM5B\/H3K4me3. Am J Cancer Res 9:2364\u20132378","journal-title":"Am J Cancer Res"},{"key":"5270_CR42","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.3892\/ol.2014.2396","volume":"8","author":"X Zhong","year":"2014","unstructured":"Zhong X, Guan X, Liu W, Zhang L (2014) Aberrant expression of NEK2 and its clinical significance in non-small cell lung cancer. Oncol Lett 8:1470\u20131476","journal-title":"Oncol Lett"},{"key":"5270_CR43","doi-asserted-by":"publisher","first-page":"2807","DOI":"10.1016\/j.cell.2021.04.041","volume":"184","author":"PTK Saunders","year":"2021","unstructured":"Saunders PTK, Horne AW (2021) Endometriosis: etiology, pathobiology, and therapeutic prospects. Cell 184:2807\u20132824","journal-title":"Cell"},{"key":"5270_CR44","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1210\/clinem\/dgab753","volume":"107","author":"TH Kim","year":"2022","unstructured":"Kim TH, Young SL, Sasaki T, Deaton JL, Schammel DP, Palomino WA, Jeong JW, Lessey BA (2022) Role of SIRT1 and progesterone resistance in normal and abnormal endometrium. J Clin Endocrinol Metab 107:788\u2013800","journal-title":"J Clin Endocrinol Metab"},{"key":"5270_CR45","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1016\/j.fertnstert.2005.08.046","volume":"85","author":"PA Klemmt","year":"2006","unstructured":"Klemmt PA, Carver JG, Kennedy SH, Koninckx PR, Mardon HJ (2006) Stromal cells from endometriotic lesions and endometrium from women with endometriosis have reduced decidualization capacity. Fertil Steril 85:564\u2013572","journal-title":"Fertil Steril"},{"key":"5270_CR46","doi-asserted-by":"publisher","first-page":"2197","DOI":"10.1210\/endo.133.5.8404671","volume":"133","author":"B Tang","year":"1993","unstructured":"Tang B, Guller S, Gurpide E (1993) Cyclic adenosine 3\u2019,5\u2019-monophosphate induces prolactin expression in stromal cells isolated from human proliferative endometrium. Endocrinology 133:2197\u20132203","journal-title":"Endocrinology"},{"key":"5270_CR47","doi-asserted-by":"crossref","unstructured":"Zhang L, Liang B, Xu H, Gong Y, Hu W, Jin Z, Wu X, Chen X, Li M, Shi L (2022) Cinobufagin induces FOXO1-regulated apoptosis, proliferation, migration, and invasion by inhibiting G9a in non-small-cell lung cancer A549 cells. J Ethnopharmacol 291, 115095","DOI":"10.1016\/j.jep.2022.115095"},{"key":"5270_CR48","doi-asserted-by":"crossref","unstructured":"Park Y, Nnamani MC, Maziarz J, Wagner GP (2016) Cis-Regulatory Evolution of Forkhead Box O1 (FOXO1), a Terminal Selector Gene for Decidual Stromal Cell Identity. Mol Biol Evol 33, 3161\u20133169","DOI":"10.1093\/molbev\/msw193"},{"key":"5270_CR49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-1-4939-8900-3_1","volume":"1890","author":"W Link","year":"2019","unstructured":"Link W (2019) Introduction to FOXO Biology. Methods Mol Biol 1890:1\u20139","journal-title":"Methods Mol Biol"},{"key":"5270_CR50","doi-asserted-by":"publisher","first-page":"4733","DOI":"10.1038\/onc.2008.104","volume":"27","author":"P Liu","year":"2008","unstructured":"Liu P, Kao TP, Huang H (2008) CDK1 promotes cell proliferation and survival via phosphorylation and inhibition of FOXO1 transcription factor. Oncogene 27:4733\u20134744","journal-title":"Oncogene"}],"container-title":["Cellular and Molecular Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-024-05270-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00018-024-05270-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-024-05270-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,25]],"date-time":"2024-05-25T07:04:15Z","timestamp":1716620655000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00018-024-05270-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,25]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["5270"],"URL":"https:\/\/doi.org\/10.1007\/s00018-024-05270-8","relation":{},"ISSN":["1420-682X","1420-9071"],"issn-type":[{"value":"1420-682X","type":"print"},{"value":"1420-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,25]]},"assertion":[{"value":"20 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 May 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 May 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 May 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Human Investigation Ethical Committee of Affiliated Hospital of Shandong Second Medical University approved this study (approved No. wyfy-2022-ky-095). This experiment was approved by the Institutional Experimental Animal Review Board of Shandong Second Medical University (approved No. 2022SDL224).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all patients for being included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All authors consent to the publication of the article.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that there are no conflicts of interest.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"237"}}