{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T13:01:05Z","timestamp":1781701265386,"version":"3.54.5"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T00:00:00Z","timestamp":1728086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T00:00:00Z","timestamp":1728086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"The Program of Suzhou Health Commission","award":["GSWS2022002"],"award-info":[{"award-number":["GSWS2022002"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072425,82072498"],"award-info":[{"award-number":["82072425,82072498"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272157 , 82272512"],"award-info":[{"award-number":["82272157 , 82272512"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017128","name":"Science Fund for Distinguished Young Scholars of Anhui Province","doi-asserted-by":"publisher","award":["2108085J40"],"award-info":[{"award-number":["2108085J40"]}],"id":[{"id":"10.13039\/100017128","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018628","name":"Scientific Research Foundation of Education Department of Anhui Province of China","doi-asserted-by":"publisher","award":["2022AH010076"],"award-info":[{"award-number":["2022AH010076"]}],"id":[{"id":"10.13039\/501100018628","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020770","name":"Young Medical Key Talents Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["QNRC2016751"],"award-info":[{"award-number":["QNRC2016751"]}],"id":[{"id":"10.13039\/501100020770","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010023","name":"Natural Science Research of Jiangsu Higher Education Institutions of China","doi-asserted-by":"publisher","award":["BE2021650"],"award-info":[{"award-number":["BE2021650"]}],"id":[{"id":"10.13039\/501100010023","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","award":["ZD2022014"],"award-info":[{"award-number":["ZD2022014"]}],"id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National and Local Engineering Laboratory of New Functional Polymer Materials","award":["SDGC2205"],"award-info":[{"award-number":["SDGC2205"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell. Mol. Life Sci."],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1007\/s00018-024-05443-5","type":"journal-article","created":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T05:01:45Z","timestamp":1728104505000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["MAGL blockade alleviates steroid-induced femoral head osteonecrosis by reprogramming BMSC fate in rat"],"prefix":"10.1007","volume":"81","author":[{"given":"Ning","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lunan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaozeng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4375-2803","authenticated-orcid":false,"given":"Dechun","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,5]]},"reference":[{"key":"5443_CR1","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.2106\/jbjs.E.01041","volume":"88","author":"MA Mont","year":"2006","unstructured":"Mont MA, Jones LC, Hungerford DS (2006) Nontraumatic osteonecrosis of the femoral head: ten years later. J Bone Joint Surg Am 88:1117\u20131132. https:\/\/doi.org\/10.2106\/jbjs.E.01041","journal-title":"J Bone Joint Surg Am"},{"key":"5443_CR2","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1016\/j.bone.2015.09.005","volume":"81","author":"L Fan","year":"2015","unstructured":"Fan L, Zhang C, Yu Z, Shi Z, Dang X, Wang K (2015) Transplantation of hypoxia preconditioned bone marrow mesenchymal stem cells enhances angiogenesis and osteogenesis in rabbit femoral head osteonecrosis. Bone 81:544\u2013553. https:\/\/doi.org\/10.1016\/j.bone.2015.09.005","journal-title":"Bone"},{"key":"5443_CR3","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1359\/jbmr.041233","volume":"20","author":"S Sivagurunathan","year":"2005","unstructured":"Sivagurunathan S, Muir MM, Brennan TC, Seale JP, Mason RS (2005) Influence of glucocorticoids on human osteoclast generation and activity. J Bone Min Res 20:390\u2013398. https:\/\/doi.org\/10.1359\/jbmr.041233","journal-title":"J Bone Min Res"},{"key":"5443_CR4","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1038\/s41419-021-04313-3","volume":"12","author":"H Sun","year":"2021","unstructured":"Sun H, Zhang W, Yang N, Xue Y, Wang T, Wang H, Zheng K, Wang Y, Zhu F, Yang H, Xu W, Xu Y, Geng D (2021) Activation of cannabinoid receptor 2 alleviates glucocorticoid-induced osteonecrosis of femoral head with osteogenesis and maintenance of blood supply. Cell Death Dis 12:1035. https:\/\/doi.org\/10.1038\/s41419-021-04313-3","journal-title":"Cell Death Dis"},{"key":"5443_CR5","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/s00198-004-1649-7","volume":"16","author":"X Li","year":"2005","unstructured":"Li X, Jin L, Cui Q, Wang GJ, Balian G (2005) Steroid effects on osteogenesis through mesenchymal cell gene expression. Osteoporos Int 16:101\u2013108. https:\/\/doi.org\/10.1007\/s00198-004-1649-7","journal-title":"Osteoporos Int"},{"key":"5443_CR6","doi-asserted-by":"publisher","first-page":"e832","DOI":"10.1038\/cddis.2013.348","volume":"4","author":"J Li","year":"2013","unstructured":"Li J, Zhang N, Huang X, Xu J, Fernandes JC, Dai K, Zhang X (2013) Dexamethasone shifts bone marrow stromal cells from osteoblasts to adipocytes by C\/EBPalpha promoter methylation. Cell Death Dis 4:e832. https:\/\/doi.org\/10.1038\/cddis.2013.348","journal-title":"Cell Death Dis"},{"key":"5443_CR7","doi-asserted-by":"publisher","first-page":"E587","DOI":"10.1152\/ajpendo.00219.2016","volume":"311","author":"M Piemontese","year":"2016","unstructured":"Piemontese M, Xiong J, Fujiwara Y, Thostenson JD, O\u2019Brien CA (2016) Cortical bone loss caused by glucocorticoid excess requires RANKL production by osteocytes and is associated with reduced OPG expression in mice. Am J Physiol Endocrinol Metab 311:E587\u2013593. https:\/\/doi.org\/10.1152\/ajpendo.00219.2016","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"5443_CR8","doi-asserted-by":"publisher","first-page":"e52481","DOI":"10.15252\/embr.202152481","volume":"22","author":"Y Hu","year":"2021","unstructured":"Hu Y, Li X, Zhi X, Cong W, Huang B, Chen H, Wang Y, Li Y, Wang L, Fang C, Guo J, Liu Y, Cui J, Cao L, Weng W, Zhou Q, Wang S, Chen X, Su J (2021) RANKL from bone marrow adipose lineage cells promotes osteoclast formation and bone loss. EMBO Rep 22:e52481. https:\/\/doi.org\/10.15252\/embr.202152481","journal-title":"EMBO Rep"},{"key":"5443_CR9","doi-asserted-by":"publisher","unstructured":"Yu W, Zhong L, Yao L, Wei Y, Gui T, Li Z, Kim H, Holdreith N, Jiang X, Tong W, Dyment N, Liu XS, Yang S, Choi Y, Ahn J, Qin L (2021) Bone marrow adipogenic lineage precursors promote osteoclastogenesis in bone remodeling and pathologic bone loss. J Clin Invest 131. https:\/\/doi.org\/10.1172\/jci140214","DOI":"10.1172\/jci140214"},{"key":"5443_CR10","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1002\/jcp.25395","volume":"232","author":"L Wang","year":"2017","unstructured":"Wang L, Yang L, Tian L, Mai P, Jia S, Yang L, Li L (2017) Cannabinoid receptor 1 mediates homing of bone marrow-derived mesenchymal stem cells triggered by Chronic Liver Injury. J Cell Physiol 232:110\u2013121. https:\/\/doi.org\/10.1002\/jcp.25395","journal-title":"J Cell Physiol"},{"key":"5443_CR11","doi-asserted-by":"publisher","first-page":"2978","DOI":"10.1038\/s41467-020-16789-2","volume":"11","author":"J Yin","year":"2020","unstructured":"Yin J, Kim SS, Choi E, Oh YT, Lin W, Kim TH, Sa JK, Hong JH, Park SH, Kwon HJ, Jin X, You Y, Kim JH, Kim H, Son J, Lee J, Nam DH, Choi KS, Shi B, Gwak HS, Yoo H, Iavarone A, Kim JH, Park JB (2020) ARS2\/MAGL signaling in glioblastoma stem cells promotes self-renewal and M2-like polarization of tumor-associated macrophages. Nat Commun 11:2978. https:\/\/doi.org\/10.1038\/s41467-020-16789-2","journal-title":"Nat Commun"},{"key":"5443_CR12","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.1111\/j.1476-5381.2012.01950.x","volume":"166","author":"CJ Fowler","year":"2012","unstructured":"Fowler CJ (2012) Monoacylglycerol lipase - a target for drug development? Br J Pharmacol 166:1568\u20131585. https:\/\/doi.org\/10.1111\/j.1476-5381.2012.01950.x","journal-title":"Br J Pharmacol"},{"issue":"Suppl 1","key":"5443_CR13","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1111\/j.1365-2826.2008.01675.x","volume":"20","author":"I Bab","year":"2008","unstructured":"Bab I, Ofek O, Tam J, Rehnelt J, Zimmer A (2008) Endocannabinoids and the regulation of bone metabolism. J Neuroendocrinol 20(Suppl 1):69\u201374. https:\/\/doi.org\/10.1111\/j.1365-2826.2008.01675.x","journal-title":"J Neuroendocrinol"},{"key":"5443_CR14","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.cmet.2009.07.006","volume":"10","author":"AI Idris","year":"2009","unstructured":"Idris AI, Sophocleous A, Landao-Bassonga E, Canals M, Milligan G, Baker D, van\u2019t Hof RJ, Ralston SH (2009) Cannabinoid receptor type 1 protects against age-related osteoporosis by regulating osteoblast and adipocyte differentiation in marrow stromal cells. Cell Metab 10:139\u2013147. https:\/\/doi.org\/10.1016\/j.cmet.2009.07.006","journal-title":"Cell Metab"},{"key":"5443_CR15","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1007\/s00223-006-0171-7","volume":"80","author":"A Scutt","year":"2007","unstructured":"Scutt A, Williamson EM (2007) Cannabinoids stimulate fibroblastic colony formation by bone marrow cells indirectly via CB2 receptors. Calcif Tissue Int 80:50\u201359. https:\/\/doi.org\/10.1007\/s00223-006-0171-7","journal-title":"Calcif Tissue Int"},{"key":"5443_CR16","doi-asserted-by":"publisher","first-page":"101057","DOI":"10.1016\/j.redox.2018.11.015","volume":"21","author":"X Wu","year":"2019","unstructured":"Wu X, Dai H, Liu L, Xu C, Yin Y, Yi J, Bielec MD, Han Y, Li S (2019) Citrate reduced oxidative damage in stem cells by regulating cellular redox signaling pathways and represent a potential treatment for oxidative stress-induced diseases. Redox Biol 21:101057. https:\/\/doi.org\/10.1016\/j.redox.2018.11.015","journal-title":"Redox Biol"},{"key":"5443_CR17","doi-asserted-by":"publisher","first-page":"105967","DOI":"10.1016\/j.phrs.2021.105967","volume":"174","author":"H Tao","year":"2021","unstructured":"Tao H, Li W, Zhang W, Yang C, Zhang C, Liang X, Yin J, Bai J, Ge G, Zhang H, Yang X, Li H, Xu Y, Hao Y, Liu Y, Geng D (2021) Urolithin A suppresses RANKL-induced osteoclastogenesis and postmenopausal osteoporosis by, suppresses inflammation and downstream NF-\u03baB activated pyroptosis pathways. Pharmacol Res 174:105967. https:\/\/doi.org\/10.1016\/j.phrs.2021.105967","journal-title":"Pharmacol Res"},{"key":"5443_CR18","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.1007\/s00213-020-05529-5","volume":"237","author":"MV DeVuono","year":"2020","unstructured":"DeVuono MV, La Caprara O, Sullivan MT, Bath A, Petrie GN, Limebeer CL, Rock EM, Hill MN, Parker LA (2020) Role of the stress response and the endocannabinoid system in \u2206(9)-tetrahydrocannabinol (THC)-induced nausea. Psychopharmacology 237:2187\u20132199. https:\/\/doi.org\/10.1007\/s00213-020-05529-5","journal-title":"Psychopharmacology"},{"key":"5443_CR19","doi-asserted-by":"publisher","first-page":"1840","DOI":"10.1038\/s41386-018-0055-3","volume":"43","author":"A Serrano","year":"2018","unstructured":"Serrano A, Pavon FJ, Buczynski MW, Schlosburg J, Natividad LA, Polis IY, Stouffer DG, Zorrilla EP, Roberto M, Cravatt BF, Martin-Fardon R, Rodriguez F, de Fonseca LH, Parsons (2018) Deficient endocannabinoid signaling in the central amygdala contributes to alcohol dependence-related anxiety-like behavior and excessive alcohol intake. Neuropsychopharmacology 43:1840\u20131850. https:\/\/doi.org\/10.1038\/s41386-018-0055-3","journal-title":"Neuropsychopharmacology"},{"key":"5443_CR20","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1111\/bph.14453","volume":"176","author":"MA Sticht","year":"2019","unstructured":"Sticht MA, Lau DJ, Keenan CM, Cavin JB, Morena M, Vemuri VK, Makriyannis A, Cravatt BF, Sharkey KA, Hill MN (2019) Endocannabinoid regulation of homeostatic feeding and stress-induced alterations in food intake in male rats. Br J Pharmacol 176:1524\u20131540. https:\/\/doi.org\/10.1111\/bph.14453","journal-title":"Br J Pharmacol"},{"key":"5443_CR21","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1097\/aln.0000000000000422","volume":"121","author":"M Ueda","year":"2014","unstructured":"Ueda M, Iwasaki H, Wang S, Murata E, Poon KY, Mao J, Martyn JA (2014) Cannabinoid receptor type 1 antagonist, AM251, attenuates mechanical allodynia and thermal hyperalgesia after burn injury. Anesthesiology 121:1311\u20131319. https:\/\/doi.org\/10.1097\/aln.0000000000000422","journal-title":"Anesthesiology"},{"key":"5443_CR22","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1186\/s12974-020-01784-7","volume":"17","author":"N Jing","year":"2020","unstructured":"Jing N, Fang B, Li Z, Tian A (2020) Exogenous activation of cannabinoid-2 receptor modulates TLR4\/MMP9 expression in a spinal cord ischemia reperfusion rat model. J Neuroinflammation 17:101. https:\/\/doi.org\/10.1186\/s12974-020-01784-7","journal-title":"J Neuroinflammation"},{"key":"5443_CR23","doi-asserted-by":"publisher","first-page":"1919","DOI":"10.1016\/s0006-2952(97)00168-8","volume":"53","author":"JJ Fern\u00e1ndez-Ruiz","year":"1997","unstructured":"Fern\u00e1ndez-Ruiz JJ, Mu\u00f1oz RM, Romero J, Villanua MA, Makriyannis A, Ramos JA (1997) Time course of the effects of different cannabimimetics on prolactin and gonadotrophin secretion: evidence for the presence of CB1 receptors in hypothalamic structures and their involvement in the effects of cannabimimetics. Biochem Pharmacol 53:1919\u20131927. https:\/\/doi.org\/10.1016\/s0006-2952(97)00168-8","journal-title":"Biochem Pharmacol"},{"key":"5443_CR24","doi-asserted-by":"publisher","first-page":"21706","DOI":"10.18632\/aging.103976","volume":"12","author":"L Xiao","year":"2020","unstructured":"Xiao L, Zhong M, Huang Y, Zhu J, Tang W, Li D, Shi J, Lu A, Yang H, Geng D, Li H, Wang Z (2020) Puerarin alleviates osteoporosis in the ovariectomy-induced mice by suppressing osteoclastogenesis via inhibition of TRAF6\/ROS-dependent MAPK\/NF-\u03baB signaling pathways. Aging 12:21706\u201321729. https:\/\/doi.org\/10.18632\/aging.103976","journal-title":"Aging"},{"key":"5443_CR25","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1136\/gutjnl-2018-316137","volume":"68","author":"A Habib","year":"2019","unstructured":"Habib A, Chokr D, Wan J, Hegde P, Mabire M, Siebert M, Ribeiro-Parenti L, Le Gall M, Lett\u00e9ron P, Pilard N, Mansouri A, Brouillet A, Tardelli M, Weiss E, Le Faouder P, Guillou H, Cravatt BF, Moreau R, Trauner M, Lotersztajn S (2019) Inhibition of monoacylglycerol lipase, an anti-inflammatory and antifibrogenic strategy in the liver. Gut 68:522\u2013532. https:\/\/doi.org\/10.1136\/gutjnl-2018-316137","journal-title":"Gut"},{"key":"5443_CR26","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1016\/j.neuron.2017.02.002","volume":"93","author":"PV Piazza","year":"2017","unstructured":"Piazza PV, Cota D, Marsicano G (2017) The CB1 receptor as the cornerstone of Exostasis. Neuron 93:1252\u20131274. https:\/\/doi.org\/10.1016\/j.neuron.2017.02.002","journal-title":"Neuron"},{"key":"5443_CR27","doi-asserted-by":"publisher","first-page":"e12691","DOI":"10.1111\/cpr.12691","volume":"52","author":"W Yan","year":"2019","unstructured":"Yan W, Cao Y, Yang H, Han N, Zhu X, Fan Z, Du J, Zhang F (2019) CB1 enhanced the osteo\/dentinogenic differentiation ability of periodontal ligament stem cells via p38 MAPK and JNK in an inflammatory environment. Cell Prolif 52:e12691. https:\/\/doi.org\/10.1111\/cpr.12691","journal-title":"Cell Prolif"},{"key":"5443_CR28","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1186\/s13075-015-0743-x","volume":"17","author":"T Lowin","year":"2015","unstructured":"Lowin T, Straub RH (2015) Cannabinoid-based drugs targeting CB1 and TRPV1, the sympathetic nervous system, and arthritis. Arthritis Res Ther 17:226. https:\/\/doi.org\/10.1186\/s13075-015-0743-x","journal-title":"Arthritis Res Ther"},{"key":"5443_CR29","doi-asserted-by":"publisher","first-page":"4008","DOI":"10.1021\/jm058238r","volume":"49","author":"J Antel","year":"2006","unstructured":"Antel J, Gregory PC, Nordheim U (2006) CB1 cannabinoid receptor antagonists for treatment of obesity and prevention of comorbid metabolic disorders. J Med Chem 49:4008\u20134016. https:\/\/doi.org\/10.1021\/jm058238r","journal-title":"J Med Chem"},{"key":"5443_CR30","doi-asserted-by":"publisher","unstructured":"Liu X, Li Z, Liu H, Zhu Y, Xia D, Wang S, Gu R, Zhang P, Liu Y, Zhou Y (2020) Flufenamic acid inhibits adipogenic differentiation of mesenchymal stem cells by antagonizing the PI3K\/AKT signaling pathway. Stem Cells Int 2020(1540905). https:\/\/doi.org\/10.1155\/2020\/1540905","DOI":"10.1155\/2020\/1540905"},{"key":"5443_CR31","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.bone.2014.08.004","volume":"68","author":"C Shi","year":"2014","unstructured":"Shi C, Qi J, Huang P, Jiang M, Zhou Q, Zhou H, Kang H, Qian N, Yang Q, Guo L, Deng L (2014) MicroRNA-17\/20a inhibits glucocorticoid-induced osteoclast differentiation and function through targeting RANKL expression in osteoblast cells. Bone 68:67\u201375. https:\/\/doi.org\/10.1016\/j.bone.2014.08.004","journal-title":"Bone"},{"key":"5443_CR32","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1080\/03602532.2019.1574303","volume":"51","author":"D Apostu","year":"2019","unstructured":"Apostu D, Lucaciu O, Mester A, Benea H, Oltean-Dan D, Onisor F, Baciut M, Bran S (2019) Cannabinoids and bone regeneration. Drug Metab Rev 51:65\u201375. https:\/\/doi.org\/10.1080\/03602532.2019.1574303","journal-title":"Drug Metab Rev"},{"key":"5443_CR33","doi-asserted-by":"publisher","first-page":"107814","DOI":"10.1016\/j.neuropharm.2019.107814","volume":"162","author":"M Feja","year":"2020","unstructured":"Feja M, Leigh MPK, Baindur AN, McGraw JJ, Wakabayashi KT, Cravatt BF, Bass CE (2020) The novel MAGL inhibitor MJN110 enhances responding to reward-predictive incentive cues by activation of CB1 receptors. Neuropharmacology 162:107814. https:\/\/doi.org\/10.1016\/j.neuropharm.2019.107814","journal-title":"Neuropharmacology"},{"key":"5443_CR34","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1002\/jcb.10592","volume":"90","author":"RM Porter","year":"2003","unstructured":"Porter RM, Huckle WR, Goldstein AS (2003) Effect of dexamethasone withdrawal on osteoblastic differentiation of bone marrow stromal cells. J Cell Biochem 90:13\u201322. https:\/\/doi.org\/10.1002\/jcb.10592","journal-title":"J Cell Biochem"},{"key":"5443_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11914-019-00498-x","volume":"17","author":"NE Lane","year":"2019","unstructured":"Lane NE (2019) Glucocorticoid-Induced osteoporosis: New insights into the pathophysiology and treatments. Curr Osteoporos Rep 17:1\u20137. https:\/\/doi.org\/10.1007\/s11914-019-00498-x","journal-title":"Curr Osteoporos Rep"},{"key":"5443_CR36","doi-asserted-by":"publisher","first-page":"2388","DOI":"10.1074\/jbc.M406294200","volume":"280","author":"E Smith","year":"2005","unstructured":"Smith E, Frenkel B (2005) Glucocorticoids inhibit the transcriptional activity of LEF\/TCF in differentiating osteoblasts in a glycogen synthase kinase-3beta-dependent and -independent manner. J Biol Chem 280:2388\u20132394. https:\/\/doi.org\/10.1074\/jbc.M406294200","journal-title":"J Biol Chem"},{"key":"5443_CR37","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1016\/j.bone.2011.08.022","volume":"49","author":"RW Wu","year":"2011","unstructured":"Wu RW, Lin TP, Ko JY, Yeh DW, Chen MW, Ke HC, Wu SL, Wang FS (2011) Cannabinoid receptor 1 regulates ERK and GSK-3\u03b2-dependent glucocorticoid inhibition of osteoblast differentiation in murine MC3T3-E1 cells. Bone 49:1255\u20131263. https:\/\/doi.org\/10.1016\/j.bone.2011.08.022","journal-title":"Bone"},{"key":"5443_CR38","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1007\/s11914-020-00607-1","volume":"18","author":"B Raphael-Mizrahi","year":"2020","unstructured":"Raphael-Mizrahi B, Gabet Y (2020) The cannabinoids Effect on bone formation and bone Healing. Curr Osteoporos Rep 18:433\u2013438. https:\/\/doi.org\/10.1007\/s11914-020-00607-1","journal-title":"Curr Osteoporos Rep"},{"key":"5443_CR39","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1111\/jnc.14059","volume":"142","author":"B Alonso","year":"2017","unstructured":"Alonso B, Bartolom\u00e9-Mart\u00edn D, Ferrero JJ, Ram\u00edrez-Franco J, Torres M, S\u00e1nchez-Prieto J (2017) CB1 receptors down-regulate a cAMP\/Epac2\/PLC pathway to silence the nerve terminals of cerebellar granule cells. J Neurochem 142:350\u2013364. https:\/\/doi.org\/10.1111\/jnc.14059","journal-title":"J Neurochem"},{"key":"5443_CR40","doi-asserted-by":"publisher","unstructured":"Ferreira S.G., Gon\u00e7alves F.Q., Marques J.M., \u00c2 Tom\u00e9 R, Rodrigues R.J., Nunes-Correia I., Ledent C, Harkany T., Venance L., Cunha R.A., K\u00f6falvi A. (2015) Presynaptic adenosine A2A receptors dampen cannabinoid CB1 receptor-mediated inhibition of corticostriatal glutamatergic transmission. Br J Pharmacol 172:1074\u20131086. https:\/\/doi.org\/10.1111\/bph.12970","DOI":"10.1111\/bph.12970"},{"key":"5443_CR41","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1016\/j.biopha.2018.11.103","volume":"110","author":"S Deng","year":"2019","unstructured":"Deng S, Dai G, Chen S, Nie Z, Zhou J, Fang H, Peng H (2019) Dexamethasone induces osteoblast apoptosis through ROS-PI3K\/AKT\/GSK3\u03b2 signaling pathway. Biomed Pharmacother 110:602\u2013608. https:\/\/doi.org\/10.1016\/j.biopha.2018.11.103","journal-title":"Biomed Pharmacother"},{"key":"5443_CR42","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/j.freeradbiomed.2022.11.003","volume":"193","author":"C Liu","year":"2022","unstructured":"Liu C, He P, Guo Y, Tian Q, Wang J, Wang G, Zhang Z, Li M (2022) Taurine attenuates neuronal ferroptosis by regulating GABA(B)\/AKT\/GSK3\u03b2\/\u03b2-catenin pathway after subarachnoid hemorrhage. Free Radic Biol Med 193:795\u2013807. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2022.11.003","journal-title":"Free Radic Biol Med"},{"key":"5443_CR43","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.bbrc.2019.08.024","volume":"518","author":"L Jia","year":"2019","unstructured":"Jia L, Zhang Y, Ji Y, Xiong Y, Zhang W, Wen Y, Xu X (2019) YAP balances the osteogenic and adipogenic differentiation of hPDLSCs in vitro partly through the Wnt\/\u03b2-catenin signaling pathway. Biochem Biophys Res Commun 518:154\u2013160. https:\/\/doi.org\/10.1016\/j.bbrc.2019.08.024","journal-title":"Biochem Biophys Res Commun"},{"key":"5443_CR44","doi-asserted-by":"publisher","first-page":"154189","DOI":"10.1016\/j.metabol.2020.154189","volume":"105","author":"L Tian","year":"2020","unstructured":"Tian L, Xiao H, Li M, Wu X, Xie Y, Zhou J, Zhang X, Wang B (2020) A novel Sprouty4-ERK1\/2-Wnt\/\u03b2-catenin regulatory loop in marrow stromal progenitor cells controls osteogenic and adipogenic differentiation. Metabolism 105:154189. https:\/\/doi.org\/10.1016\/j.metabol.2020.154189","journal-title":"Metabolism"},{"key":"5443_CR45","doi-asserted-by":"publisher","first-page":"118044","DOI":"10.1016\/j.lfs.2020.118044","volume":"257","author":"R Zhao","year":"2020","unstructured":"Zhao R, Tao L, Qiu S, Shen L, Tian Y, Gong Z, Tao ZB, Zhu Y (2020) Melatonin rescues glucocorticoid-induced inhibition of osteoblast differentiation in MC3T3-E1 cells via the PI3K\/AKT and BMP\/Smad signalling pathways. Life Sci 257:118044. https:\/\/doi.org\/10.1016\/j.lfs.2020.118044","journal-title":"Life Sci"},{"key":"5443_CR46","doi-asserted-by":"publisher","first-page":"4564","DOI":"10.1523\/jneurosci.0786-09.2009","volume":"29","author":"MT Viscomi","year":"2009","unstructured":"Viscomi MT, Oddi S, Latini L, Pasquariello N, Florenzano F, Bernardi G, Molinari M, Maccarrone M (2009) Selective CB2 receptor agonism protects central neurons from remote axotomy-induced apoptosis through the PI3K\/Akt pathway. J Neurosci 29:4564\u20134570. https:\/\/doi.org\/10.1523\/jneurosci.0786-09.2009","journal-title":"J Neurosci"},{"key":"5443_CR47","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1007\/s11481-015-9609-x","volume":"10","author":"O Gomez","year":"2015","unstructured":"Gomez O, Sanchez-Rodriguez MA, Ortega-Gutierrez S, Vazquez-Villa H, Guaza C, Molina-Holgado F, Molina-Holgado E (2015) A basal tone of 2-Arachidonoylglycerol contributes to early oligodendrocyte progenitor proliferation by activating Phosphatidylinositol 3-Kinase (PI3K)\/AKT and the mammalian target of Rapamycin (MTOR) Pathways. J Neuroimmune Pharmacol 10:309\u2013317. https:\/\/doi.org\/10.1007\/s11481-015-9609-x","journal-title":"J Neuroimmune Pharmacol"},{"key":"5443_CR48","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.cytogfr.2023.03.002","volume":"70","author":"M Chen","year":"2023","unstructured":"Chen M, Fu W, Xu H, Liu CJ (2023) Pathogenic mechanisms of glucocorticoid-induced osteoporosis. Cytokine Growth Factor Rev 70:54\u201366. https:\/\/doi.org\/10.1016\/j.cytogfr.2023.03.002","journal-title":"Cytokine Growth Factor Rev"},{"key":"5443_CR49","doi-asserted-by":"publisher","first-page":"640867","DOI":"10.3389\/fcell.2021.640867","volume":"9","author":"H Liu","year":"2021","unstructured":"Liu H, Zhou C, Qi D, Gao Y, Zhu M, Tao T, Sun X, Xiao J (2021) Inhibiting Monoacylglycerol Lipase suppresses RANKL-Induced osteoclastogenesis and alleviates Ovariectomy-Induced Bone loss. Front Cell Dev Biol 9:640867. https:\/\/doi.org\/10.3389\/fcell.2021.640867","journal-title":"Front Cell Dev Biol"},{"key":"5443_CR50","doi-asserted-by":"publisher","unstructured":"Cheng CH, Chen LR, Chen KH (2022) Osteoporosis due to hormone imbalance: an overview of the effects of Estrogen Deficiency and glucocorticoid overuse on bone turnover. Int J Mol Sci 23. https:\/\/doi.org\/10.3390\/ijms23031376","DOI":"10.3390\/ijms23031376"}],"container-title":["Cellular and Molecular Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-024-05443-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00018-024-05443-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-024-05443-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T17:02:03Z","timestamp":1728147723000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00018-024-05443-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,5]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["5443"],"URL":"https:\/\/doi.org\/10.1007\/s00018-024-05443-5","relation":{},"ISSN":["1420-682X","1420-9071"],"issn-type":[{"value":"1420-682X","type":"print"},{"value":"1420-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,5]]},"assertion":[{"value":"13 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 August 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 October 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All experiments were conducted in the Soochow University Orthopaedic Institute. The study protocol and the use and care of animals were reviewed and approved by the Tab of Soochow University\u2019s First Affiliated Hospital\u2019s Ethics Committee, Suzhou Medical College of Soochow University (202112A0630).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors consent to publishing this work.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no conflicts of interest for this work.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"418"}}