{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:32:49Z","timestamp":1793039569903,"version":"4.5.0"},"reference-count":145,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T00:00:00Z","timestamp":1733184000000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["XS grant"],"award-info":[{"award-number":["XS grant"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014076","name":"Stichting ALS Nederland","doi-asserted-by":"publisher","award":["GoALS"],"award-info":[{"award-number":["GoALS"]}],"id":[{"id":"10.13039\/501100014076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014076","name":"Stichting ALS Nederland","doi-asserted-by":"publisher","award":["TOTALS"],"award-info":[{"award-number":["TOTALS"]}],"id":[{"id":"10.13039\/501100014076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014076","name":"Stichting ALS Nederland","doi-asserted-by":"publisher","award":["MUSALS"],"award-info":[{"award-number":["MUSALS"]}],"id":[{"id":"10.13039\/501100014076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014076","name":"Stichting ALS Nederland","doi-asserted-by":"publisher","award":["ATAXALS"],"award-info":[{"award-number":["ATAXALS"]}],"id":[{"id":"10.13039\/501100014076","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ALS Cure project"},{"DOI":"10.13039\/100017732","name":"E-rare3","doi-asserted-by":"crossref","award":["MAXOMOD"],"award-info":[{"award-number":["MAXOMOD"]}],"id":[{"id":"10.13039\/100017732","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Rare-3","award":["INTEGRALS"],"award-info":[{"award-number":["INTEGRALS"]}]},{"DOI":"10.13039\/100013278","name":"JPND","doi-asserted-by":"crossref","award":["TRIAGE"],"award-info":[{"award-number":["TRIAGE"]}],"id":[{"id":"10.13039\/100013278","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell. Mol. Life Sci."],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neurodegenerative disorders such as Alzheimer\u2019s disease (AD), amyotrophic lateral sclerosis (ALS) and Parkinson\u2019s disease (PD) affect millions of people worldwide. Curative treatment for these neurodegenerative disorders is still lacking and therefore a further understanding of their cause and progression is urgently needed. Extracellular vesicles (EVs) are nanosized vesicles loaded with cargo, such as proteins and miRNAs, that are released by cells and play an important role in intercellular communication. Intercellular communication through EVs can contribute to the spread of pathological proteins, such as amyloid-beta and tau, or cause pathogenesis through other mechanisms. In addition, EVs may serve as potential biomarkers for diagnosis and for monitoring disease progression. In this review, we summarize and discuss recent advances in our understanding of the role of EVs in AD, ALS an PD with an emphasis on dysregulated cargo in each disease. We highlight shared dysregulated cargo between these diseases, discuss underlying pathways, and outline future implications for therapeutic strategies.<\/jats:p>","DOI":"10.1007\/s00018-024-05522-7","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T19:48:15Z","timestamp":1733255295000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Shared and distinct changes in the molecular cargo of extracellular vesicles in different neurodegenerative diseases"],"prefix":"10.1007","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1628-9513","authenticated-orcid":false,"given":"Anna F.","family":"Wiersema","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa","family":"Rennenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7879-4291","authenticated-orcid":false,"given":"Suzy","family":"Varderidou-Minasian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1631-6440","authenticated-orcid":false,"given":"R. Jeroen","family":"Pasterkamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,3]]},"reference":[{"key":"5522_CR1","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1111\/j.1750-3639.1996.tb00878.x","volume":"6","author":"CW Cotman","year":"1996","unstructured":"Cotman CW, Su JH (1996) Mechanisms of neuronal death in Alzheimer\u2019s disease. Brain Pathol 6:493\u2013506. https:\/\/doi.org\/10.1111\/j.1750-3639.1996.tb00878.x","journal-title":"Brain Pathol"},{"key":"5522_CR2","doi-asserted-by":"publisher","first-page":"2084","DOI":"10.1016\/S0140-6736(17)31287-4","volume":"390","author":"MA van Es","year":"2017","unstructured":"van Es MA, Hardiman O, Chio A, Al-Chalabi A, Pasterkamp RJ, Veldink JH, van den Berg LH (2017) Amyotrophic lateral sclerosis. Lancet 390:2084\u20132098. https:\/\/doi.org\/10.1016\/S0140-6736(17)31287-4","journal-title":"Lancet"},{"key":"5522_CR3","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.freeradbiomed.2013.01.018","volume":"62","author":"DT Dexter","year":"2013","unstructured":"Dexter DT, Jenner P (2013) Parkinson disease: from pathology to molecular disease mechanisms. Free Radic Biol Med 62:132\u2013144. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2013.01.018","journal-title":"Free Radic Biol Med"},{"key":"5522_CR4","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1083\/jcb.201211138","volume":"200","author":"G Raposo","year":"2013","unstructured":"Raposo G, Stoorvogel W (2013) Extracellular vesicles: exosomes, microvesicles, and friends. J Cell Biol 200:373\u2013383. https:\/\/doi.org\/10.1083\/jcb.201211138","journal-title":"J Cell Biol"},{"key":"5522_CR5","doi-asserted-by":"publisher","first-page":"18","DOI":"10.4103\/1673-5374.343882","volume":"18","author":"M Garcia-Contreras","year":"2023","unstructured":"Garcia-Contreras M, Thakor A (2023) Extracellular vesicles in Alzheimer\u2019s disease: from pathology to therapeutic approaches. Neural Regen Res 18:18. https:\/\/doi.org\/10.4103\/1673-5374.343882","journal-title":"Neural Regen Res"},{"key":"5522_CR6","doi-asserted-by":"publisher","DOI":"10.1080\/20013078.2018.1535750","author":"C Th\u00e9ry","year":"2018","unstructured":"Th\u00e9ry C, Witwer KW, Aikawa E, Alcaraz MJ, Anderson JD, Andriantsitohaina R et al (2018) Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the international society for extracellular vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles. https:\/\/doi.org\/10.1080\/20013078.2018.1535750","journal-title":"J Extracell Vesicles"},{"key":"5522_CR7","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1038\/ncb1596","volume":"9","author":"H Valadi","year":"2007","unstructured":"Valadi H, Ekstr\u00f6m K, Bossios A, Sj\u00f6strand M, Lee JJ, L\u00f6tvall JO (2007) Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 9:654\u2013659. https:\/\/doi.org\/10.1038\/ncb1596","journal-title":"Nat Cell Biol"},{"key":"5522_CR8","doi-asserted-by":"publisher","first-page":"170","DOI":"10.3390\/ijms17020170","volume":"17","author":"H Kalra","year":"2016","unstructured":"Kalra H, Drummen G, Mathivanan S (2016) Focus on extracellular vesicles: introducing the next small big thing. Int J Mol Sci 17:170. https:\/\/doi.org\/10.3390\/ijms17020170","journal-title":"Int J Mol Sci"},{"key":"5522_CR9","doi-asserted-by":"publisher","first-page":"851","DOI":"10.3390\/cells9040851","volume":"9","author":"J Saint-Pol","year":"2020","unstructured":"Saint-Pol J, Gosselet F, Duban-Deweer S, Pottiez G, Karamanos Y (2020) Targeting and crossing the blood-brain barrier with extracellular vesicles. Cells 9:851. https:\/\/doi.org\/10.3390\/cells9040851","journal-title":"Cells"},{"key":"5522_CR10","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1002\/alz.12089","volume":"16","author":"S Muraoka","year":"2020","unstructured":"Muraoka S, DeLeo AM, Sethi MK, Yukawa-Takamatsu K, Yang Z, Ko J, Hogan JD, Ruan Z, You Y, Wang Y, Medalla M, Ikezu S, Chen M, Xia W, Gorantla S, Gendelman HE, Issadore D, Zaia J, Ikezu T (2020) Proteomic and biological profiling of extracellular vesicles from Alzheimer\u2019s disease human brain tissues. Alzheimer Dement 16:896\u2013907. https:\/\/doi.org\/10.1002\/alz.12089","journal-title":"Alzheimer Dement"},{"key":"5522_CR11","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00487","author":"D Sproviero","year":"2018","unstructured":"Sproviero D, La Salvia S, Giannini M, Crippa V, Gagliardi S, Bernuzzi S, Diamanti L, Ceroni M, Pansarasa O, Poletti A, Cereda C (2018) Pathological proteins are transported by extracellular vesicles of sporadic amyotrophic lateral sclerosis patients. Front Neurosci. https:\/\/doi.org\/10.3389\/fnins.2018.00487","journal-title":"Front Neurosci"},{"key":"5522_CR12","doi-asserted-by":"publisher","first-page":"3590","DOI":"10.1111\/ene.15537","volume":"29","author":"Y Yan","year":"2022","unstructured":"Yan Y, Pu J, Zheng R, Fang Y, Gu L, Guo T, Si X, Zhou C, Chen Y, Liu Y, Guan X, Xu X, Yan Y, Yin X, Zhang M, Tao Z, Zhang B (2022) Different patterns of exosomal <scp>\u03b1-synuclein<\/scp> between Parkinson\u2019s disease and probable rapid eye movement sleep behavior disorder. Eur J Neurol 29:3590\u20133599. https:\/\/doi.org\/10.1111\/ene.15537","journal-title":"Eur J Neurol"},{"key":"5522_CR13","doi-asserted-by":"publisher","first-page":"5979","DOI":"10.7150\/thno.40122","volume":"10","author":"S Varderidou-Minasian","year":"2020","unstructured":"Varderidou-Minasian S, Lorenowicz MJ (2020) Mesenchymal stromal\/stem cell-derived extracellular vesicles in tissue repair: challenges and opportunities. Theranostics 10:5979\u20135997. https:\/\/doi.org\/10.7150\/thno.40122","journal-title":"Theranostics"},{"key":"5522_CR14","doi-asserted-by":"publisher","first-page":"3805","DOI":"10.1007\/s00216-018-1052-4","volume":"410","author":"M Ding","year":"2018","unstructured":"Ding M, Wang C, Lu X, Zhang C, Zhou Z, Chen X, Zhang CY, Zen K, Zhang C (2018) Comparison of commercial exosome isolation kits for circulating exosomal microRNA profiling. Anal Bioanal Chem 410:3805\u20133814. https:\/\/doi.org\/10.1007\/s00216-018-1052-4","journal-title":"Anal Bioanal Chem"},{"key":"5522_CR15","doi-asserted-by":"publisher","DOI":"10.1002\/jex2.35","author":"DE Gomes","year":"2022","unstructured":"Gomes DE, Witwer KW (2022) L1CAM-associated extracellular vesicles: a systematic review of nomenclature, sources, separation, and characterization. J Extracell Biol. https:\/\/doi.org\/10.1002\/jex2.35","journal-title":"J Extracell Biol"},{"key":"5522_CR16","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1038\/s41592-021-01174-8","volume":"18","author":"M Norman","year":"2021","unstructured":"Norman M, Ter-Ovanesyan D, Trieu W, Lazarovits R, Kowal EJK, Lee JH, Chen-Plotkin AS, Regev A, Church GM, Walt DR (2021) L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma. Nat Method 18:631\u2013634. https:\/\/doi.org\/10.1038\/s41592-021-01174-8","journal-title":"Nat Method"},{"key":"5522_CR17","doi-asserted-by":"publisher","first-page":"721","DOI":"10.7150\/ijbs.79063","volume":"19","author":"A Cano","year":"2023","unstructured":"Cano A, Ettcheto M, Bernuz M, Puerta R, Esteban de Antonio E, S\u00e1nchez-L\u00f3pez E, Souto EB, Camins A, Mart\u00ed M, Pividori MI, Boada M, Ruiz A (2023) Extracellular vesicles, the emerging mirrors of brain physiopathology. Int J Biol Sci 19:721\u2013743. https:\/\/doi.org\/10.7150\/ijbs.79063","journal-title":"Int J Biol Sci"},{"key":"5522_CR18","unstructured":"World Health Organization (WHO), dementia, (2023). https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/dementia. Accessed 22 July 2024."},{"key":"5522_CR19","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.molmed.2005.02.009","volume":"11","author":"FM LaFerla","year":"2005","unstructured":"LaFerla FM, Oddo S (2005) Alzheimer\u2019s disease: A\u03b2, tau and synaptic dysfunction. Trend Mol Med 11:170\u2013176. https:\/\/doi.org\/10.1016\/j.molmed.2005.02.009","journal-title":"Trend Mol Med"},{"key":"5522_CR20","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1093\/brain\/awaa376","volume":"144","author":"Z Ruan","year":"2021","unstructured":"Ruan Z, Pathak D, Venkatesan Kalavai S, Yoshii-Kitahara A, Muraoka S, Bhatt N, Takamatsu-Yukawa K, Hu J, Wang Y, Hersh S, Ericsson M, Gorantla S, Gendelman HE, Kayed R, Ikezu S, Luebke JI, Ikezu T (2021) Alzheimer\u2019s disease brain-derived extracellular vesicles spread tau pathology in interneurons. Brain 144:288\u2013309. https:\/\/doi.org\/10.1093\/brain\/awaa376","journal-title":"Brain"},{"key":"5522_CR21","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/s00401-018-1868-1","volume":"136","author":"M Sardar Sinha","year":"2018","unstructured":"Sardar Sinha M, Ansell-Schultz A, Civitelli L, Hildesj\u00f6 C, Larsson M, Lannfelt L, Ingelsson M, Hallbeck M (2018) Alzheimer\u2019s disease pathology propagation by exosomes containing toxic amyloid-beta oligomers. Acta Neuropathol 136:41\u201356. https:\/\/doi.org\/10.1007\/s00401-018-1868-1","journal-title":"Acta Neuropathol"},{"key":"5522_CR22","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1038\/nrg3074","volume":"12","author":"M Esteller","year":"2011","unstructured":"Esteller M (2011) Non-coding RNAs in human disease. Nat Rev Genet 12:861\u2013874. https:\/\/doi.org\/10.1038\/nrg3074","journal-title":"Nat Rev Genet"},{"key":"5522_CR23","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s40035-019-0169-5","volume":"8","author":"A G\u00e1mez-Valero","year":"2019","unstructured":"G\u00e1mez-Valero A, Campdelacreu J, Vilas D, Ispierto L, Re\u00f1\u00e9 R, \u00c1lvarez R, Armengol MP, Borr\u00e0s FE, Beyer K (2019) Exploratory study on microRNA profiles from plasma-derived extracellular vesicles in Alzheimer\u2019s disease and dementia with Lewy bodies. Transl Neurodegener 8:31. https:\/\/doi.org\/10.1186\/s40035-019-0169-5","journal-title":"Transl Neurodegener"},{"key":"5522_CR24","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2015.00426","author":"R von Bernhardi","year":"2015","unstructured":"von Bernhardi R, Cornejo F, Parada GE, Eugen\u00edn J (2015) Role of TGF\u03b2 signaling in the pathogenesis of Alzheimer\u2019s disease. Front Cell Neurosci. https:\/\/doi.org\/10.3389\/fncel.2015.00426","journal-title":"Front Cell Neurosci"},{"key":"5522_CR25","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3390\/ph11010012","volume":"11","author":"R Peron","year":"2018","unstructured":"Peron R, Vatanabe I, Manzine P, Camins A, Cominetti M (2018) Alpha-secretase ADAM10 regulation: insights into Alzheimer\u2019s disease treatment. Pharmaceuticals 11:12. https:\/\/doi.org\/10.3390\/ph11010012","journal-title":"Pharmaceuticals"},{"key":"5522_CR26","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1007\/s12031-022-02012-y","volume":"72","author":"DY Durur","year":"2022","unstructured":"Durur DY, Tastan B, Ugur Tufekci K, Olcum M, Uzuner H, Karak\u00fclah G, Yener G, Genc S (2022) Alteration of miRNAs in small neuron-derived extracellular vesicles of Alzheimer\u2019s disease patients and the effect of extracellular vesicles on microglial immune responses. J Mol Neurosci 72:1182\u20131194. https:\/\/doi.org\/10.1007\/s12031-022-02012-y","journal-title":"J Mol Neurosci"},{"key":"5522_CR27","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.01208","author":"DJ Cha","year":"2019","unstructured":"Cha DJ, Mengel D, Mustapic M, Liu W, Selkoe DJ, Kapogiannis D, Galasko D, Rissman RA, Bennett DA, Walsh DM (2019) miR-212 and miR-132 are downregulated in neurally derived plasma exosomes of Alzheimer\u2019s patients. Front Neurosci. https:\/\/doi.org\/10.3389\/fnins.2019.01208","journal-title":"Front Neurosci"},{"key":"5522_CR28","doi-asserted-by":"publisher","first-page":"4742","DOI":"10.1093\/nar\/gks151","volume":"40","author":"A Wanet","year":"2012","unstructured":"Wanet A, Tacheny A, Arnould T, Renard P (2012) miR-212\/132 expression and functions: within and beyond the neuronal compartment. Nucl Acid Res 40:4742\u20134753. https:\/\/doi.org\/10.1093\/nar\/gks151","journal-title":"Nucl Acid Res"},{"key":"5522_CR29","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1007\/s00401-018-1880-5","volume":"136","author":"R El Fatimy","year":"2018","unstructured":"El Fatimy R, Li S, Chen Z, Mushannen T, Gongala S, Wei Z, Balu DT, Rabinovsky R, Cantlon A, Elkhal A, Selkoe DJ, Sonntag KC, Walsh DM, Krichevsky AM (2018) MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways. Acta Neuropathol 136:537\u2013555. https:\/\/doi.org\/10.1007\/s00401-018-1880-5","journal-title":"Acta Neuropathol"},{"key":"5522_CR30","doi-asserted-by":"publisher","first-page":"4952","DOI":"10.1002\/alz.13055","volume":"19","author":"A Kumar","year":"2023","unstructured":"Kumar A, Su Y, Sharma M, Singh S, Kim S, Peavey JJ, Suerken CK, Lockhart SN, Whitlow CT, Craft S, Hughes TM, Deep G (2023) MicroRNA expression in extracellular vesicles as a novel blood-based biomarker for Alzheimer\u2019s disease. Alzheimer Dement 19:4952\u20134966. https:\/\/doi.org\/10.1002\/alz.13055","journal-title":"Alzheimer Dement"},{"key":"5522_CR31","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.642079","author":"F Zhao","year":"2021","unstructured":"Zhao F, Zhao H, Fan J, Wang R, Han Z, Tao Z, Zheng Y, Yan F, Huang Y, Yu L, Zhang X, Qi X, Zhang L, Luo Y, Ma Y (2021) MiR-29a knockout aggravates neurological damage by pre-polarizing M1 microglia in experimental rat models of acute stroke. Front Genet. https:\/\/doi.org\/10.3389\/fgene.2021.642079","journal-title":"Front Genet"},{"key":"5522_CR32","doi-asserted-by":"publisher","first-page":"1458","DOI":"10.55730\/1300-0144.5484","volume":"52","author":"E Ta\u015fdelen","year":"2022","unstructured":"Ta\u015fdelen E, Kizil ET\u00d6, Aydemir ST, Yalap \u00d6E, Bing\u00f6l AP, Kutlay N (2022) Determination of miR-373 and miR-204 levels in neuronal exosomes in Alzheimer?s disease. Turk J Med Sci. 52:1458\u20131467. https:\/\/doi.org\/10.55730\/1300-0144.5484","journal-title":"Turk J Med Sci."},{"key":"5522_CR33","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1136\/jnnp-2017-317492","volume":"89","author":"R Schneider","year":"2018","unstructured":"Schneider R, McKeever P, Kim T, Graff C, van Swieten JC, Karydas A, Boxer A, Rosen H, Miller BL, Laforce R Jr, Galimberti D, Masellis M, Borroni B, Zhang Z, Zinman L, Rohrer JD, Tartaglia MC, Robertson J (2018) Downregulation of exosomal miR-204-5p and miR-632 as a biomarker for FTD: a GENFI study. J Neurol Neurosurg Psychiatry 89:851\u2013858. https:\/\/doi.org\/10.1136\/jnnp-2017-317492","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"5522_CR34","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1002\/2211-5463.12345","volume":"8","author":"W Zhang","year":"2018","unstructured":"Zhang W, Zhong B, Zhang C, Luo C, Zhan Y (2018) miR-373 regulates inflammatory cytokine-mediated chondrocyte proliferation in osteoarthritis by targeting the P2X7 receptor. FEBS Open Bio 8:325\u2013331. https:\/\/doi.org\/10.1002\/2211-5463.12345","journal-title":"FEBS Open Bio"},{"key":"5522_CR35","doi-asserted-by":"publisher","first-page":"3084","DOI":"10.1007\/s12035-021-02323-y","volume":"58","author":"Z Dong","year":"2021","unstructured":"Dong Z, Gu H, Guo Q, Liang S, Xue J, Yao F, Liu X, Li F, Liu H, Sun L, Zhao K (2021) Profiling of serum exosome MiRNA reveals the potential of a MiRNA panel as diagnostic biomarker for Alzheimer\u2019s disease. Mol Neurobiol 58:3084\u20133094. https:\/\/doi.org\/10.1007\/s12035-021-02323-y","journal-title":"Mol Neurobiol"},{"key":"5522_CR36","doi-asserted-by":"publisher","first-page":"473","DOI":"10.2174\/1567202616666191111124516","volume":"16","author":"Q Ji","year":"2020","unstructured":"Ji Q, Wang X, Cai J, Du X, Sun H, Zhang N (2020) MiR-22-3p regulates amyloid \u03b2 deposit in mice model of Alzheimer\u2019s disease by targeting mitogen-activated protein kinase 14. Curr Neurovasc Res 16:473\u2013480. https:\/\/doi.org\/10.2174\/1567202616666191111124516","journal-title":"Curr Neurovasc Res"},{"key":"5522_CR37","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.neuroscience.2020.02.044","volume":"432","author":"F Li","year":"2020","unstructured":"Li F, Xie X-Y, Sui X-F, Wang P, Chen Z, Zhang J-B (2020) Profile of pathogenic proteins and MicroRNAs in plasma-derived extracellular vesicles in Alzheimer\u2019s disease: a pilot study. Neuroscience 432:240\u2013246. https:\/\/doi.org\/10.1016\/j.neuroscience.2020.02.044","journal-title":"Neuroscience"},{"key":"5522_CR38","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023789","volume":"6","author":"KE Biron","year":"2011","unstructured":"Biron KE, Dickstein DL, Gopaul R, Jefferies WA (2011) Amyloid triggers extensive cerebral angiogenesis causing blood brain barrier permeability and hypervascularity in Alzheimer\u2019s disease. PLoS ONE 6:e23789. https:\/\/doi.org\/10.1371\/journal.pone.0023789","journal-title":"PLoS ONE"},{"key":"5522_CR39","doi-asserted-by":"publisher","first-page":"227","DOI":"10.3892\/mmr.2020.11118","volume":"22","author":"D Wang","year":"2020","unstructured":"Wang D, Wang P, Bian X, Xu S, Zhou Q, Zhang Y, Ding M, Han M, Huang L, Bi J, Jia Y, Xie Z (2020) Elevated plasma levels of exosomal BACE1-AS combined with the volume and thickness of the right entorhinal cortex may serve as a biomarker for the detection of Alzheimer\u2019s disease. Mol Med Rep 22:227\u2013238. https:\/\/doi.org\/10.3892\/mmr.2020.11118","journal-title":"Mol Med Rep"},{"key":"5522_CR40","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.581882","author":"KM Kim","year":"2020","unstructured":"Kim KM, Meng Q, Perez de Acha O, Mustapic M, Cheng A, Eren E, Kundu G, Piao Y, Munk R, Wood WH, De S, Noh JH, Delannoy M, Cheng L, Abdelmohsen K, Kapogiannis D, Gorospe M (2020) Mitochondrial RNA in Alzheimer\u2019s disease circulating extracellular vesicles. Front Cell Dev Biol. https:\/\/doi.org\/10.3389\/fcell.2020.581882","journal-title":"Front Cell Dev Biol"},{"key":"5522_CR41","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1111\/j.1471-4159.2008.05347.x","volume":"106","author":"PB Shelat","year":"2008","unstructured":"Shelat PB, Chalimoniuk M, Wang J, Strosznajder JB, Lee JC, Sun AY, Simonyi A, Sun GY (2008) Amyloid beta peptide and NMDA induce ROS from NADPH oxidase and AA release from cytosolic phospholipase A 2 in cortical neurons. J Neurochem 106:45\u201355. https:\/\/doi.org\/10.1111\/j.1471-4159.2008.05347.x","journal-title":"J Neurochem"},{"key":"5522_CR42","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.766082","author":"W Cohn","year":"2021","unstructured":"Cohn W, Melnik M, Huang C, Teter B, Chandra S, Zhu C, McIntire LB, John V, Gylys KH, Bilousova T (2021) Multi-omics analysis of microglial extracellular vesicles from human Alzheimer\u2019s disease brain tissue reveals disease-associated signatures. Front Pharmacol. https:\/\/doi.org\/10.3389\/fphar.2021.766082","journal-title":"Front Pharmacol"},{"key":"5522_CR43","doi-asserted-by":"publisher","first-page":"229","DOI":"10.14336\/AD.2022.0607","volume":"14","author":"D Luo","year":"2023","unstructured":"Luo D, Liu H, Liu H, Wu W, Zhu H, Ge W, Ma C (2023) Long RNA profiles of human brain extracellular vesicles provide new insights into the pathogenesis of Alzheimer\u2019s disease. Aging Dis 14:229. https:\/\/doi.org\/10.14336\/AD.2022.0607","journal-title":"Aging Dis"},{"key":"5522_CR44","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1038\/s41592-022-01487-2","volume":"19","author":"AF Nielsen","year":"2022","unstructured":"Nielsen AF, Bindereif A, Bozzoni I, Hanan M, Hansen TB, Irimia M, Kadener S, Kristensen LS, Legnini I, Morlando M, Jarlstad Olesen MT, Pasterkamp RJ, Preibisch S, Rajewsky N, Suenkel C, Kjems J (2022) Best practice standards for circular RNA research. Nat Method 19:1208\u20131220. https:\/\/doi.org\/10.1038\/s41592-022-01487-2","journal-title":"Nat Method"},{"key":"5522_CR45","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2016.00074","author":"D van Rossum","year":"2016","unstructured":"van Rossum D, Verheijen BM, Pasterkamp RJ (2016) Circular RNAs: novel regulators of neuronal development. Front Mol Neurosci. https:\/\/doi.org\/10.3389\/fnmol.2016.00074","journal-title":"Front Mol Neurosci"},{"key":"5522_CR46","doi-asserted-by":"publisher","first-page":"18518","DOI":"10.1038\/s41598-021-97969-y","volume":"11","author":"JE Nielsen","year":"2021","unstructured":"Nielsen JE, Honor\u00e9 B, Vesterg\u00e5rd K, Maltesen RG, Christiansen G, B\u00f8ge AU, Kristensen SR, Pedersen S (2021) Shotgun-based proteomics of extracellular vesicles in Alzheimer\u2019s disease reveals biomarkers involved in immunological and coagulation pathways. Sci Rep 11:18518. https:\/\/doi.org\/10.1038\/s41598-021-97969-y","journal-title":"Sci Rep"},{"key":"5522_CR47","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1074\/jbc.RA118.005352","volume":"294","author":"WS Hur","year":"2019","unstructured":"Hur WS, Mazinani N, Lu XJD, Yefet LS, Byrnes JR, Ho L, Yeon JH, Filipenko S, Wolberg AS, Jefferies WA, Kastrup CJ (2019) Coagulation factor XIIIa cross-links amyloid \u03b2 into dimers and oligomers and to blood proteins. J Biol Chem 294:390\u2013396. https:\/\/doi.org\/10.1074\/jbc.RA118.005352","journal-title":"J Biol Chem"},{"key":"5522_CR48","doi-asserted-by":"publisher","first-page":"2878","DOI":"10.1523\/JNEUROSCI.2534-16.2017","volume":"37","author":"M Jo","year":"2017","unstructured":"Jo M, Kim J-H, Song GJ, Seo M, Hwang EM, Suk K (2017) Astrocytic orosomucoid-2 modulates microglial activation and neuroinflammation. J Neurosci 37:2878\u20132894. https:\/\/doi.org\/10.1523\/JNEUROSCI.2534-16.2017","journal-title":"J Neurosci"},{"key":"5522_CR49","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.mvr.2012.05.003","volume":"84","author":"S Zhang","year":"2012","unstructured":"Zhang S, Mark KS (2012) \u03b11-Acid glycoprotein induced effects in rat brain microvessel endothelial cells. Microvasc Res 84:161\u2013168. https:\/\/doi.org\/10.1016\/j.mvr.2012.05.003","journal-title":"Microvasc Res"},{"key":"5522_CR50","doi-asserted-by":"publisher","first-page":"3095","DOI":"10.1007\/s00018-009-0109-0","volume":"66","author":"JN Buxbaum","year":"2009","unstructured":"Buxbaum JN, Reixach N (2009) Transthyretin: the servant of many masters. Cell Mol Life Sci 66:3095\u20133101. https:\/\/doi.org\/10.1007\/s00018-009-0109-0","journal-title":"Cell Mol Life Sci"},{"key":"5522_CR51","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1002\/alz.12166","volume":"17","author":"L Jia","year":"2021","unstructured":"Jia L, Zhu M, Kong C, Pang Y, Zhang H, Qiu Q, Wei C, Tang Y, Wang Q, Li Y, Li T, Li F, Wang Q, Li Y, Wei Y, Jia J (2021) Blood neuro-exosomal synaptic proteins predict Alzheimer\u2019s disease at the asymptomatic stage. Alzheimer Dement 17:49\u201360. https:\/\/doi.org\/10.1002\/alz.12166","journal-title":"Alzheimer Dement"},{"key":"5522_CR52","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.3390\/biomedicines9111587","volume":"9","author":"PJ Yao","year":"2021","unstructured":"Yao PJ, Eren E, Goetzl EJ, Kapogiannis D (2021) Mitochondrial electron transport chain protein abnormalities detected in plasma extracellular vesicles in Alzheimer\u2019s disease. Biomedicines 9:1587. https:\/\/doi.org\/10.3390\/biomedicines9111587","journal-title":"Biomedicines"},{"key":"5522_CR53","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1186\/s13195-022-01133-1","volume":"14","author":"H Cai","year":"2022","unstructured":"Cai H, Pang Y, Wang Q, Qin W, Wei C, Li Y, Li T, Li F, Wang Q, Li Y, Wei Y, Jia L (2022) Proteomic profiling of circulating plasma exosomes reveals novel biomarkers of Alzheimer\u2019s disease. Alzheimer Res Ther 14:181. https:\/\/doi.org\/10.1186\/s13195-022-01133-1","journal-title":"Alzheimer Res Ther"},{"key":"5522_CR54","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02884","author":"F Denorme","year":"2019","unstructured":"Denorme F, Vanhoorelbeke K, De Meyer SF (2019) von Willebrand factor and platelet glycoprotein Ib: a Thromboinflammatory Axis in stroke. Front Immunol. https:\/\/doi.org\/10.3389\/fimmu.2019.02884","journal-title":"Front Immunol"},{"key":"5522_CR55","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3233\/JAD-180035","volume":"64","author":"A Kaminari","year":"2018","unstructured":"Kaminari A, Tsilibary EC, Tzinia A (2018) A new perspective in utilizing MMP-9 as a therapeutic target for Alzheimer\u2019s disease and type 2 diabetes mellitus. J Alzheimer Dis 64:1\u201316. https:\/\/doi.org\/10.3233\/JAD-180035","journal-title":"J Alzheimer Dis"},{"key":"5522_CR56","doi-asserted-by":"publisher","first-page":"1681","DOI":"10.1002\/acn3.51155","volume":"7","author":"D Gu","year":"2020","unstructured":"Gu D, Liu F, Meng M, Zhang L, Gordon ML, Wang Y, Cai L, Zhang N (2020) Elevated matrix metalloproteinase-9 levels in neuronal extracellular vesicles in Alzheimer\u2019s disease. Ann Clin Transl Neurol 7:1681\u20131691. https:\/\/doi.org\/10.1002\/acn3.51155","journal-title":"Ann Clin Transl Neurol"},{"key":"5522_CR57","doi-asserted-by":"publisher","first-page":"2838","DOI":"10.1007\/s12035-022-02762-1","volume":"59","author":"T Soares Martins","year":"2022","unstructured":"Soares Martins T, Mar\u00e7alo R, da Cruz e Silva CB, Trindade D, Catita J, Amado F, Melo T, Rosa IM, Vogelgsang J, Wiltfang J, da Cruz e Silva OAB, Henriques AG (2022) Novel exosome biomarker candidates for Alzheimer\u2019s disease unravelled through mass spectrometry analysis. Mol Neurobiol 59:2838\u20132854. https:\/\/doi.org\/10.1007\/s12035-022-02762-1","journal-title":"Mol Neurobiol"},{"key":"5522_CR58","doi-asserted-by":"publisher","first-page":"3020","DOI":"10.1093\/brain\/awl255","volume":"129","author":"J Padmanabhan","year":"2006","unstructured":"Padmanabhan J, Levy M, Dickson DW, Potter H (2006) Alpha1-antichymotrypsin, an inflammatory protein overexpressed in Alzheimer\u2019s disease brain, induces tau phosphorylation in neurons. Brain 129:3020\u20133034. https:\/\/doi.org\/10.1093\/brain\/awl255","journal-title":"Brain"},{"key":"5522_CR59","doi-asserted-by":"publisher","first-page":"3649","DOI":"10.1016\/j.molimm.2008.04.025","volume":"45","author":"LA Trouw","year":"2008","unstructured":"Trouw LA, Nielsen HM, Minthon L, Londos E, Landberg G, Veerhuis R, Janciauskiene S, Blom AM (2008) C4b-binding protein in Alzheimer\u2019s disease: binding to A\u03b21\u201342 and to dead cells. Mol Immunol 45:3649\u20133660. https:\/\/doi.org\/10.1016\/j.molimm.2008.04.025","journal-title":"Mol Immunol"},{"key":"5522_CR60","doi-asserted-by":"publisher","first-page":"1959","DOI":"10.3390\/cells9091959","volume":"9","author":"S Muraoka","year":"2020","unstructured":"Muraoka S, Jedrychowski MP, Yanamandra K, Ikezu S, Gygi SP, Ikezu T (2020) Proteomic profiling of extracellular vesicles derived from cerebrospinal fluid of Alzheimer\u2019s disease patients: a pilot study. Cells 9:1959. https:\/\/doi.org\/10.3390\/cells9091959","journal-title":"Cells"},{"key":"5522_CR61","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.neuron.2006.07.019","volume":"51","author":"SL Karsten","year":"2006","unstructured":"Karsten SL, Sang T-K, Gehman LT, Chatterjee S, Liu J, Lawless GM, Sengupta S, Berry RW, Pomakian J, Oh HS, Schulz C, Hui K-S, Wiedau-Pazos M, Vinters HV, Binder LI, Geschwind DH, Jackson GR (2006) A genomic screen for modifiers of tauopathy identifies puromycin-sensitive aminopeptidase as an inhibitor of tau-induced neurodegeneration. Neuron 51:549\u2013560. https:\/\/doi.org\/10.1016\/j.neuron.2006.07.019","journal-title":"Neuron"},{"key":"5522_CR62","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s40478-019-0660-3","volume":"7","author":"H Gerber","year":"2019","unstructured":"Gerber H, Mosser S, Boury-Jamot B, Stumpe M, Piersigilli A, Goepfert C, Dengjel J, Albrecht U, Magara F, Fraering PC (2019) The APMAP interactome reveals new modulators of APP processing and beta-amyloid production that are altered in Alzheimer\u2019s disease. Acta Neuropathol Commun 7:13. https:\/\/doi.org\/10.1186\/s40478-019-0660-3","journal-title":"Acta Neuropathol Commun"},{"key":"5522_CR63","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1021\/bi2018078","volume":"51","author":"K Voss","year":"2012","unstructured":"Voss K, Combs B, Patterson KR, Binder LI, Gamblin TC (2012) Hsp70 alters tau function and aggregation in an isoform specific manner. Biochemistry 51:888\u2013898. https:\/\/doi.org\/10.1021\/bi2018078","journal-title":"Biochemistry"},{"key":"5522_CR64","doi-asserted-by":"publisher","first-page":"4828","DOI":"10.1002\/alz.13066","volume":"19","author":"M Chatterjee","year":"2023","unstructured":"Chatterjee M, \u00d6zdemir S, Kunadt M, Koel-Simmelink M, Boiten W, Piepkorn L, Pham TV, Chiasserini D, Piersma SR, Knol JC, M\u00f6bius W, Mollenhauer B, van der Flier WM, Jimenez CR, Teunissen CE, Jahn O, Schneider A (2023) C1q is increased in cerebrospinal fluid-derived extracellular vesicles in Alzheimer\u2019s disease: a multi-cohort proteomics and immuno-assay validation study. Alzheimer Dement 19:4828\u20134840. https:\/\/doi.org\/10.1002\/alz.13066","journal-title":"Alzheimer Dement"},{"key":"5522_CR65","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12183","author":"Y You","year":"2022","unstructured":"You Y, Muraoka S, Jedrychowski MP, Hu J, McQuade AK, Young-Pearse T, Aslebagh R, Shaffer SA, Gygi SP, Blurton-Jones M, Poon WW, Ikezu T (2022) Human neural cell type-specific extracellular vesicle proteome defines disease-related molecules associated with activated astrocytes in Alzheimer\u2019s disease brain. J Extracell Vesicles. https:\/\/doi.org\/10.1002\/jev2.12183","journal-title":"J Extracell Vesicles"},{"key":"5522_CR66","doi-asserted-by":"publisher","first-page":"4023","DOI":"10.1523\/JNEUROSCI.3442-16.2017","volume":"37","author":"C-C Liu","year":"2017","unstructured":"Liu C-C, Hu J, Zhao N, Wang J, Wang N, Cirrito JR, Kanekiyo T, Holtzman DM, Bu G (2017) Astrocytic LRP1 mediates brain A\u03b2 clearance and impacts amyloid deposition. J Neurosci 37:4023\u20134031. https:\/\/doi.org\/10.1523\/JNEUROSCI.3442-16.2017","journal-title":"J Neurosci"},{"key":"5522_CR67","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1038\/s41586-020-2156-5","volume":"580","author":"JN Rauch","year":"2020","unstructured":"Rauch JN, Luna G, Guzman E, Audouard M, Challis C, Sibih YE, Leshuk C, Hernandez I, Wegmann S, Hyman BT, Gradinaru V, Kampmann M, Kosik KS (2020) LRP1 is a master regulator of tau uptake and spread. Nature 580:381\u2013385. https:\/\/doi.org\/10.1038\/s41586-020-2156-5","journal-title":"Nature"},{"key":"5522_CR68","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1186\/s40478-021-01245-z","volume":"9","author":"C Vandendriessche","year":"2021","unstructured":"Vandendriessche C, Balusu S, Van Cauwenberghe C, Brkic M, Pauwels M, Plehiers N, Bruggeman A, Dujardin P, Van Imschoot G, Van Wonterghem E, Hendrix A, Baeke F, De Rycke R, Gevaert K, Vandenbroucke RE (2021) Importance of extracellular vesicle secretion at the blood\u2013cerebrospinal fluid interface in the pathogenesis of Alzheimer\u2019s disease. Acta Neuropathol Commun 9:143. https:\/\/doi.org\/10.1186\/s40478-021-01245-z","journal-title":"Acta Neuropathol Commun"},{"key":"5522_CR69","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.1021\/acs.jproteome.0c00934","volume":"20","author":"S Muraoka","year":"2021","unstructured":"Muraoka S, Jedrychowski MP, Iwahara N, Abdullah M, Onos KD, Keezer KJ, Hu J, Ikezu S, Howell GR, Gygi SP, Ikezu T (2021) Enrichment of neurodegenerative microglia signature in brain-derived extracellular vesicles isolated from Alzheimer\u2019s disease mouse models. J Proteom Res 20:1733\u20131743. https:\/\/doi.org\/10.1021\/acs.jproteome.0c00934","journal-title":"J Proteom Res"},{"key":"5522_CR70","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1074\/mcp.RA120.002079","volume":"19","author":"S Podvin","year":"2020","unstructured":"Podvin S, Jones A, Liu Q, Aulston B, Ransom L, Ames J, Shen G, Lietz CB, Jiang Z, O\u2019Donoghue AJ, Winston C, Ikezu T, Rissman RA, Yuan S, Hook V (2020) Dysregulation of exosome cargo by mutant tau expressed in human-induced pluripotent stem cell (iPSC) neurons revealed by proteomics analyses. Mol Cell Proteom 19:1017\u20131034. https:\/\/doi.org\/10.1074\/mcp.RA120.002079","journal-title":"Mol Cell Proteom"},{"key":"5522_CR71","doi-asserted-by":"publisher","first-page":"310","DOI":"10.3109\/17482960802566824","volume":"10","author":"A Chi\u00f2","year":"2009","unstructured":"Chi\u00f2 A, Logroscino G, Hardiman O, Swingler R, Mitchell D, Beghi E, Traynor BG (2009) On behalf of the Eurals consortium, prognostic factors in ALS: a critical review. Amyotroph Lateral Scler 10:310\u2013323. https:\/\/doi.org\/10.3109\/17482960802566824","journal-title":"Amyotroph Lateral Scler"},{"key":"5522_CR72","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.01310","author":"R Mejzini","year":"2019","unstructured":"Mejzini R, Flynn LL, Pitout IL, Fletcher S, Wilton SD, Akkari PA, Genetics ALS (2019) Mechanisms, and therapeutics: where are we now? Front Neurosci. https:\/\/doi.org\/10.3389\/fnins.2019.01310","journal-title":"Front Neurosci"},{"key":"5522_CR73","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-802973-2.00013-6","author":"EO Talbott","year":"2016","unstructured":"Talbott EO, Malek AM, Lacomis D (2016) The epidemiology of amyotrophic lateral sclerosis. Neuroepidemiology. https:\/\/doi.org\/10.1016\/B978-0-12-802973-2.00013-6","journal-title":"Neuroepidemiology"},{"key":"5522_CR74","doi-asserted-by":"publisher","first-page":"614","DOI":"10.3390\/antiox11040614","volume":"11","author":"C Peggion","year":"2022","unstructured":"Peggion C, Scalcon V, Massimino ML, Nies K, Lopreiato R, Rigobello MP, Bertoli A (2022) SOD1 in ALS: taking stock in pathogenic mechanisms and the role of glial and muscle cells. Antioxidants 11:614. https:\/\/doi.org\/10.3390\/antiox11040614","journal-title":"Antioxidants"},{"key":"5522_CR75","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1038\/s41582-018-0047-2","volume":"14","author":"R Balendra","year":"2018","unstructured":"Balendra R, Isaacs AM (2018) C9orf72-mediated ALS and FTD: multiple pathways to disease. Nat Rev Neurol 14:544\u2013558. https:\/\/doi.org\/10.1038\/s41582-018-0047-2","journal-title":"Nat Rev Neurol"},{"key":"5522_CR76","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.200116","author":"SA Banack","year":"2020","unstructured":"Banack SA, Dunlop RA, Cox PA (2020) An miRNA fingerprint using neural-enriched extracellular vesicles from blood plasma: towards a biomarker for amyotrophic lateral sclerosis\/motor neuron disease. Open Biol. https:\/\/doi.org\/10.1098\/rsob.200116","journal-title":"Open Biol"},{"key":"5522_CR77","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2022.120396","volume":"442","author":"SA Banack","year":"2022","unstructured":"Banack SA, Dunlop RA, Stommel EW, Mehta P, Cox PA (2022) miRNA extracted from extracellular vesicles is a robust biomarker of amyotrophic lateral sclerosis. J Neurol Sci 442:120396. https:\/\/doi.org\/10.1016\/j.jns.2022.120396","journal-title":"J Neurol Sci"},{"key":"5522_CR78","doi-asserted-by":"publisher","first-page":"9013","DOI":"10.1523\/JNEUROSCI.5210-12.2013","volume":"33","author":"YL Chen","year":"2013","unstructured":"Chen YL, Shen CKJ (2013) Modulation of mGluR-dependent MAP1B translation and AMPA receptor endocytosis by MicroRNA miR-146a-5p. J Neurosci 33:9013\u20139020. https:\/\/doi.org\/10.1523\/JNEUROSCI.5210-12.2013","journal-title":"J Neurosci"},{"key":"5522_CR79","doi-asserted-by":"publisher","first-page":"38951","DOI":"10.1074\/jbc.M110.178848","volume":"285","author":"JG Cui","year":"2010","unstructured":"Cui JG, Li YY, Zhao Y, Bhattacharjee S, Lukiw WJ (2010) Differential regulation of interleukin-1 receptor-associated kinase-1 (IRAK-1) and IRAK-2 by MicroRNA-146a and NF-\u03baB in stressed human astroglial cells and in Alzheimer disease. J Biol Chem 285:38951\u201338960. https:\/\/doi.org\/10.1074\/jbc.M110.178848","journal-title":"J Biol Chem"},{"key":"5522_CR80","doi-asserted-by":"publisher","first-page":"4443","DOI":"10.1007\/s00018-014-1628-x","volume":"71","author":"K Varendi","year":"2014","unstructured":"Varendi K, Kumar A, H\u00e4rma MA, Andressoo JO (2014) miR-1, miR-10b, miR-155, and miR-191 are novel regulators of BDNF. Cell Mol Life Sci 71:4443\u20134456. https:\/\/doi.org\/10.1007\/s00018-014-1628-x","journal-title":"Cell Mol Life Sci"},{"key":"5522_CR81","doi-asserted-by":"publisher","first-page":"5528","DOI":"10.1038\/s41598-023-32717-y","volume":"13","author":"JA Kim","year":"2023","unstructured":"Kim JA, Park C, Sung JJ, Seo DJ, Choi SJ, Hong YH (2023) Small RNA sequencing of circulating small extracellular vesicles microRNAs in patients with amyotrophic lateral sclerosis. Sci Rep 13:5528. https:\/\/doi.org\/10.1038\/s41598-023-32717-y","journal-title":"Sci Rep"},{"key":"5522_CR82","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.neuroscience.2023.05.030","volume":"524","author":"Y Liu","year":"2023","unstructured":"Liu Y, Ding M, Pan S, Zhou R, Yao J, Fu R, Yu H, Lu Z (2023) MicroRNA-23a-3p is upregulated in plasma exosomes of bulbar-onset ALS patients and targets ERBB4. Neuroscience 524:65\u201378. https:\/\/doi.org\/10.1016\/j.neuroscience.2023.05.030","journal-title":"Neuroscience"},{"key":"5522_CR83","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2021.739016","author":"T Lo","year":"2021","unstructured":"Lo T, Figueroa-Romero C, Hur J, Pacut C, Stoll E, Spring C, Lewis R, Nair A, Goutman SA, Sakowski SA, Nagrath S, Feldman EL (2021) Extracellular vesicles in serum and central nervous system tissues contain microRNA signatures in sporadic amyotrophic lateral sclerosis. Front Mol Neurosci. https:\/\/doi.org\/10.3389\/fnmol.2021.739016","journal-title":"Front Mol Neurosci"},{"key":"5522_CR84","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/1750-1326-4-36","volume":"4","author":"J Montag","year":"2009","unstructured":"Montag J, Hitt R, Opitz L, Schulz-Schaeffer WJ, Hunsmann G, Motzkus D (2009) Upregulation of miRNA hsa-miR-342-3p in experimental and idiopathic prion disease. Mol Neurodegener 4:36. https:\/\/doi.org\/10.1186\/1750-1326-4-36","journal-title":"Mol Neurodegener"},{"key":"5522_CR85","doi-asserted-by":"publisher","DOI":"10.1177\/17590914231197527","author":"S Marton","year":"2023","unstructured":"Marton S, Miquel E, Acosta-Rodr\u00edguez J, Fontenla S, Libisch G, Cassina P (2023) SOD1 G93A astrocyte-derived extracellular vesicles induce motor neuron death by a miRNA-155-5p-mediated mechanism. ASN Neuro. https:\/\/doi.org\/10.1177\/17590914231197527","journal-title":"ASN Neuro"},{"key":"5522_CR86","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2020.112209","volume":"395","author":"C Gomes","year":"2020","unstructured":"Gomes C, Sequeira C, Barbosa M, Cunha C, Vaz AR, Brites D (2020) Astrocyte regional diversity in ALS includes distinct aberrant phenotypes with common and causal pathological processes. Exp Cell Res 395:112209. https:\/\/doi.org\/10.1016\/j.yexcr.2020.112209","journal-title":"Exp Cell Res"},{"key":"5522_CR87","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.3390\/cells11071186","volume":"11","author":"C Gomes","year":"2022","unstructured":"Gomes C, Sequeira C, Likhite S, Dennys CN, Kolb SJ, Shaw PJ, Vaz AR, Kaspar BK, Meyer K, Brites D (2022) Neurotoxic astrocytes directly converted from sporadic and familial ALS patient fibroblasts reveal signature diversities and miR-146a theragnostic potential in specific subtypes. Cells 11:1186. https:\/\/doi.org\/10.3390\/cells11071186","journal-title":"Cells"},{"key":"5522_CR88","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1038\/nrn3302","volume":"13","author":"RJ Pasterkamp","year":"2012","unstructured":"Pasterkamp RJ (2012) Getting neural circuits into shape with semaphorins. Nat Rev Neurosci 13:605\u2013618. https:\/\/doi.org\/10.1038\/nrn3302","journal-title":"Nat Rev Neurosci"},{"key":"5522_CR89","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1016\/j.ebiom.2018.11.067","volume":"40","author":"A Varcianna","year":"2019","unstructured":"Varcianna A, Myszczynska MA, Castelli LM, O\u2019Neill B, Kim Y, Talbot J, Nyberg S, Nyamali I, Heath PR, Stopford MJ, Hautbergue GM, Ferraiuolo L (2019) Micro-RNAs secreted through astrocyte-derived extracellular vesicles cause neuronal network degeneration in C9orf72 ALS. EBioMedicine 40:626\u2013635. https:\/\/doi.org\/10.1016\/j.ebiom.2018.11.067","journal-title":"EBioMedicine"},{"key":"5522_CR90","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00574","author":"Y Chen","year":"2019","unstructured":"Chen Y, Xia K, Chen L, Fan D (2019) Increased interleukin-6 levels in the astrocyte-derived exosomes of sporadic amyotrophic lateral sclerosis patients. Front Neurosci. https:\/\/doi.org\/10.3389\/fnins.2019.00574","journal-title":"Front Neurosci"},{"key":"5522_CR91","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1007\/s11684-021-0905-y","volume":"16","author":"Q Zhou","year":"2022","unstructured":"Zhou Q, He L, Hu J, Gao Y, Shen D, Ni Y, Qin Y, Liang H, Liu J, Le W, Chen S (2022) Increased expression of coronin-1a in amyotrophic lateral sclerosis: a potential diagnostic biomarker and therapeutic target. Front Med 16:723\u2013735. https:\/\/doi.org\/10.1007\/s11684-021-0905-y","journal-title":"Front Med"},{"key":"5522_CR92","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2021.105360","volume":"154","author":"J Root","year":"2021","unstructured":"Root J, Merino P, Nuckols A, Johnson M, Kukar T (2021) Lysosome dysfunction as a cause of neurodegenerative diseases: lessons from frontotemporal dementia and amyotrophic lateral sclerosis. Neurobiol Dis 154:105360. https:\/\/doi.org\/10.1016\/j.nbd.2021.105360","journal-title":"Neurobiol Dis"},{"key":"5522_CR93","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/s13024-021-00470-3","volume":"16","author":"L Pasetto","year":"2021","unstructured":"Pasetto L, Callegaro S, Corbelli A, Fiordaliso F, Ferrara D, Brunelli L, Sestito G, Pastorelli R, Bianchi E, Cretich M, Chiari M, Potrich C, Moglia C, Corbo M, Sorar\u00f9 G, Lunetta C, Calvo A, Chi\u00f2 A, Mora G, Pennuto M, Quattrone A, Rinaldi F, D\u2019Agostino VG, Basso M, Bonetto V (2021) Decoding distinctive features of plasma extracellular vesicles in amyotrophic lateral sclerosis. Mol Neurodegener 16:52. https:\/\/doi.org\/10.1186\/s13024-021-00470-3","journal-title":"Mol Neurodegener"},{"key":"5522_CR94","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2017.00099","author":"M Filareti","year":"2017","unstructured":"Filareti M, Luotti S, Pasetto L, Pignataro M, Paolella K, Messina P, Pupillo E, Filosto M, Lunetta C, Mandrioli J, Fuda G, Calvo A, Chi\u00f2 A, Corbo M, Bendotti C, Beghi E, Bonetto V (2017) Decreased levels of foldase and chaperone proteins are associated with an early-onset amyotrophic lateral sclerosis. Front Mol Neurosci. https:\/\/doi.org\/10.3389\/fnmol.2017.00099","journal-title":"Front Mol Neurosci"},{"key":"5522_CR95","doi-asserted-by":"publisher","first-page":"15699","DOI":"10.1074\/jbc.M112.425066","volume":"288","author":"M Basso","year":"2013","unstructured":"Basso M, Pozzi S, Tortarolo M, Fiordaliso F, Bisighini C, Pasetto L, Spaltro G, Lidonnici D, Gensano F, Battaglia E, Bendotti C, Bonetto V (2013) Mutant copper-zinc superoxide dismutase (SOD1) induces protein secretion pathway alterations and exosome release in astrocytes. J Biol Chem 288:15699\u201315711. https:\/\/doi.org\/10.1074\/jbc.M112.425066","journal-title":"J Biol Chem"},{"key":"5522_CR96","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.tcb.2018.10.004","volume":"29","author":"T Mor\u00e1n Luengo","year":"2019","unstructured":"Mor\u00e1n Luengo T, Mayer MP, R\u00fcdiger SGD (2019) The Hsp70\u2013Hsp90 chaperone cascade in protein folding. Trends Cell Biol 29:164\u2013177. https:\/\/doi.org\/10.1016\/j.tcb.2018.10.004","journal-title":"Trends Cell Biol"},{"key":"5522_CR97","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1002\/jcsm.12945","volume":"13","author":"L Le Gall","year":"2022","unstructured":"Le Gall L, Duddy WJ, Martinat C, Mariot V, Connolly O, Milla V, Anakor E, Ouandaogo ZG, Millecamps S, Lain\u00e9 J, Vijayakumar UG, Knoblach S, Raoul C, Lucas O, Loeffler JP, Bede P, Behin A, Blasco H, Bruneteau G, Del Mar Amador M, Devos D, Henriques A, Hesters A, Lacomblez L, Laforet P, Langlet T, Leblanc P, Le Forestier N, Maisonobe T, Meininger V, Robelin L, Salachas F, Stojkovic T, Querin G, Dumonceaux J, Butler Browne G, Gonz\u00e1lez De Aguilar J, Duguez S, Pradat PF (2022) Muscle cells of sporadic amyotrophic lateral sclerosis patients secrete neurotoxic vesicles. J Cachexia Sarcopenia Muscle 13:1385\u20131402. https:\/\/doi.org\/10.1002\/jcsm.12945","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"5522_CR98","doi-asserted-by":"publisher","first-page":"3744","DOI":"10.1074\/jbc.RA118.004825","volume":"294","author":"JM Silverman","year":"2019","unstructured":"Silverman JM, Christy D, Shyu CC, Moon KM, Fernando S, Gidden Z, Cowan CM, Ban Y, Stacey RG, Grad LI, McAlary L, Mackenzie IR, Foster LJ, Cashman NR (2019) CNS-derived extracellular vesicles from superoxide dismutase 1 (SOD1)G93A ALS mice originate from astrocytes and neurons and carry misfolded SOD1. J Biol Chem 294:3744\u20133759. https:\/\/doi.org\/10.1074\/jbc.RA118.004825","journal-title":"J Biol Chem"},{"key":"5522_CR99","unstructured":"Parkinson\u2019s Disease: challenges, progress, and promise, national institute of neurological disorders and stroke. (2023). https:\/\/www.ninds.nih.gov\/current-research\/focus-%20disorders\/focus-parkinsons-disease-research\/parkinsons-disease-challenges-progress-and-promise. Accessed 9 April 2024."},{"key":"5522_CR100","unstructured":"Parkinson disease. Who (2023). https:\/\/www.who.int\/news-room\/fact-%20sheets\/detail\/parkinson-disease. Accessed 9 April 2024."},{"key":"5522_CR101","unstructured":"What is Parkinson\u2019s? Parkinson\u2019s foundation (2023). https:\/\/www.parkinson.org\/understanding-parkinsons\/what-is-parkinsons. Accessed 9 April 2024."},{"issue":"4","key":"5522_CR102","first-page":"879","volume":"152","author":"M Baba","year":"1998","unstructured":"Baba M, Nakajo S, Tu PH, Tomita T, Nakaya K, Lee VM, Trojanowski JQ, Iwatsubo T (1998) Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson\u2019s disease and dementia with Lewy bodies. Am J Pathol 152(4):879","journal-title":"Am J Pathol"},{"key":"5522_CR103","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1038\/42166","volume":"388","author":"MG Spillantini","year":"1997","unstructured":"Spillantini MG, Schmidt ML, Lee VMY, Trojanowski JQ, Jakes R, Goedert M (1997) \u03b1-synuclein in Lewy bodies. Nature 388:839\u2013840. https:\/\/doi.org\/10.1038\/42166","journal-title":"Nature"},{"key":"5522_CR104","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1007\/s00401-012-1013-5","volume":"124","author":"H Houlden","year":"2012","unstructured":"Houlden H, Singleton AB (2012) The genetics and neuropathology of Parkinson\u2019s disease. Acta Neuropathol 124:325\u2013338. https:\/\/doi.org\/10.1007\/s00401-012-1013-5","journal-title":"Acta Neuropathol"},{"key":"5522_CR105","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.3390\/cells9071687","volume":"9","author":"M Pajares","year":"2020","unstructured":"Pajares M, Rojo AI, Manda G, Bosc\u00e1 L, Cuadrado A (2020) Inflammation in Parkinson\u2019s disease: mechanisms and therapeutic implications. Cells 9:1687. https:\/\/doi.org\/10.3390\/cells9071687","journal-title":"Cells"},{"key":"5522_CR106","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1038\/ncb1644","volume":"9","author":"H Plun-Favreau","year":"2007","unstructured":"Plun-Favreau H, Klupsch K, Moisoi N, Gandhi S, Kjaer S, Frith D, Harvey K, Deas E, Harvey RJ, McDonald N, Wood NW, Martins LM, Downward J (2007) The mitochondrial protease HtrA2 is regulated by Parkinson\u2019s disease-associated kinase PINK1. Nat Cell Biol 9:1243\u20131252. https:\/\/doi.org\/10.1038\/ncb1644","journal-title":"Nat Cell Biol"},{"key":"5522_CR107","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1016\/J.BBRC.2016.09.090","volume":"483","author":"C Quek","year":"2017","unstructured":"Quek C, Hill AF (2017) The role of extracellular vesicles in neurodegenerative diseases. Biochem Biophys Res Commun 483:1178\u20131186. https:\/\/doi.org\/10.1016\/J.BBRC.2016.09.090","journal-title":"Biochem Biophys Res Commun"},{"key":"5522_CR108","doi-asserted-by":"publisher","first-page":"324","DOI":"10.5607\/en.2014.23.4.324","volume":"23","author":"A Oueslati","year":"2014","unstructured":"Oueslati A, Ximerakis M, Vekrellis K (2014) Protein transmission, seeding and degradation: key steps for \u03b1-synuclein prion-like propagation. Exp Neurobiol 23:324\u2013336. https:\/\/doi.org\/10.5607\/en.2014.23.4.324","journal-title":"Exp Neurobiol"},{"key":"5522_CR109","doi-asserted-by":"publisher","first-page":"37043","DOI":"10.18632\/oncotarget.6158","volume":"6","author":"Y Gui","year":"2015","unstructured":"Gui Y, Liu H, Zhang L, Lv W, Hu X (2015) Altered microRNA profiles in cerebrospinal fluid exosome in Parkinson disease and Alzheimer disease. Oncotarget 6:37043\u201337053. https:\/\/doi.org\/10.18632\/oncotarget.6158","journal-title":"Oncotarget"},{"key":"5522_CR110","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s40035-021-00249-y","volume":"10","author":"S He","year":"2021","unstructured":"He S, Huang L, Shao C, Nie T, Xia L, Cui B, Lu F, Zhu L, Chen B, Yang Q (2021) Several miRNAs derived from serum extracellular vesicles are potential biomarkers for early diagnosis and progression of Parkinson\u2019s disease. Transl Neurodegener 10:25. https:\/\/doi.org\/10.1186\/s40035-021-00249-y","journal-title":"Transl Neurodegener"},{"key":"5522_CR111","doi-asserted-by":"publisher","first-page":"2737","DOI":"10.3390\/ijms22052737","volume":"22","author":"D Sproviero","year":"2021","unstructured":"Sproviero D, Gagliardi S, Zucca S, Arigoni M, Giannini M, Garofalo M, Olivero M, Dell\u2019Orco M, Pansarasa O, Bernuzzi S, Avenali M, Cotta Ramusino M, Diamanti L, Minafra B, Perini G, Zangaglia R, Costa A, Ceroni M, Perrone-Bizzozero NI, Calogero RA, Cereda C (2021) Different miRNA profiles in plasma derived small and large extracellular vesicles from patients with neurodegenerative diseases. Int J Mol Sci 22:2737. https:\/\/doi.org\/10.3390\/ijms22052737","journal-title":"Int J Mol Sci"},{"key":"5522_CR112","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.785741","author":"D Sproviero","year":"2022","unstructured":"Sproviero D, Gagliardi S, Zucca S, Arigoni M, Giannini M, Garofalo M, Fantini V, Pansarasa O, Avenali M, Ramusino MC, Diamanti L, Minafra B, Perini G, Zangaglia R, Costa A, Ceroni M, Calogero RA, Cereda C (2022) Extracellular vesicles derived from plasma of patients with neurodegenerative disease have common transcriptomic profiling. Front Aging Neurosci. https:\/\/doi.org\/10.3389\/fnagi.2022.785741","journal-title":"Front Aging Neurosci"},{"key":"5522_CR113","doi-asserted-by":"publisher","DOI":"10.1111\/cns.14435","author":"Q Wang","year":"2024","unstructured":"Wang Q, Wang H, Zhao X, Han C, Liu C, Li Z, Du T, Sui Y, Zhang X, Zhang J, Xiao Y, Cai G, Meng F (2024) Transcriptome sequencing of circular <scp>RNA<\/scp> reveals the involvement of hsa-SCMH1_0001 in the pathogenesis of Parkinson\u2019s disease. CNS Neurosci Ther. https:\/\/doi.org\/10.1111\/cns.14435","journal-title":"CNS Neurosci Ther"},{"key":"5522_CR114","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1111\/cns.13277","volume":"26","author":"Q Wang","year":"2020","unstructured":"Wang Q, Han C, Wang K, Sui Y, Li Z, Chen N, Fan S, Shimabukuro M, Wang F, Meng F (2020) Integrated analysis of exosomal lncRNA and mRNA expression profiles reveals the involvement of lnc-MKRN2-42:1 in the pathogenesis of Parkinson\u2019s disease. CNS Neurosci Ther 26:527\u2013537. https:\/\/doi.org\/10.1111\/cns.13277","journal-title":"CNS Neurosci Ther"},{"key":"5522_CR115","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.parkreldis.2021.11.020","volume":"93","author":"I Manna","year":"2021","unstructured":"Manna I, Quattrone A, De Benedittis S, Vescio B, Iaccino E, Quattrone A (2021) Exosomal miRNA as peripheral biomarkers in Parkinson\u2019s disease and progressive supranuclear palsy: a pilot study. Parkinsonism Relat Disord 93:77\u201384. https:\/\/doi.org\/10.1016\/j.parkreldis.2021.11.020","journal-title":"Parkinsonism Relat Disord"},{"key":"5522_CR116","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2022.1037903","author":"P Bhattacharyya","year":"2023","unstructured":"Bhattacharyya P, Biswas A, Biswas SC (2023) Brain-enriched miR-128: reduced in exosomes from Parkinson\u2019s patient plasma, improves synaptic integrity, and prevents 6-OHDA mediated neuronal apoptosis. Front Cell Neurosci. https:\/\/doi.org\/10.3389\/fncel.2022.1037903","journal-title":"Front Cell Neurosci"},{"key":"5522_CR117","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.357","author":"L Caldi Gomes","year":"2021","unstructured":"Caldi Gomes L, Roser A, Jain G, Pena Centeno T, Maass F, Schilde L, May C, Schneider A, B\u00e4hr M, Marcus K, Fischer A, Lingor P (2021) MicroRNAs from extracellular vesicles as a signature for Parkinson\u2019s disease. Clin Transl Med. https:\/\/doi.org\/10.1002\/ctm2.357","journal-title":"Clin Transl Med"},{"key":"5522_CR118","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.neulet.2017.02.045","volume":"644","author":"XY Cao","year":"2017","unstructured":"Cao XY, Lu JM, Zhao ZQ, Li MC, Lu T, An XS, Xue LJ (2017) MicroRNA biomarkers of Parkinson\u2019s disease in serum exosome-like microvesicles. Neurosci Lett 644:94\u201399. https:\/\/doi.org\/10.1016\/j.neulet.2017.02.045","journal-title":"Neurosci Lett"},{"key":"5522_CR119","doi-asserted-by":"publisher","first-page":"2743","DOI":"10.3390\/ijms21082743","volume":"21","author":"M Sancandi","year":"2020","unstructured":"Sancandi M, Uysal-Onganer P, Kraev I, Mercer A, Lange S (2020) Protein deimination signatures in plasma and plasma-EVs and protein deimination in the brain vasculature in a rat model of pre-motor Parkinson\u2019s disease. Int J Mol Sci 21:2743. https:\/\/doi.org\/10.3390\/ijms21082743","journal-title":"Int J Mol Sci"},{"key":"5522_CR120","doi-asserted-by":"publisher","first-page":"2951","DOI":"10.3390\/ijms22062951","volume":"22","author":"F Anastasi","year":"2021","unstructured":"Anastasi F, Masciandaro SM, Del Carratore R, Dell\u2019Anno MT, Signore G, Falleni A, McDonnell LA, Bongioanni P (2021) Proteomics profiling of neuron-derived small extracellular vesicles from human plasma: enabling single-subject analysis. Int J Mol Sci 22:2951. https:\/\/doi.org\/10.3390\/ijms22062951","journal-title":"Int J Mol Sci"},{"key":"5522_CR121","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.2217\/epi-2019-0222","volume":"11","author":"T Zhou","year":"2019","unstructured":"Zhou T, Lin D, Chen Y, Peng S, Jing X, Lei M, Tao E, Liang Y (2019) \u03b1-synuclein accumulation in SH-SY5Y cell impairs autophagy in microglia by exosomes overloading miR-19a-3p. Epigenomics 11:1661\u20131677. https:\/\/doi.org\/10.2217\/epi-2019-0222","journal-title":"Epigenomics"},{"key":"5522_CR122","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.neuro.2017.04.007","volume":"64","author":"DS Harischandra","year":"2018","unstructured":"Harischandra DS, Ghaisas S, Rokad D, Zamanian M, Jin H, Anantharam V, Kimber M, Kanthasamy A, Kanthasamy AG (2018) Environmental neurotoxicant manganese regulates exosome-mediated extracellular miRNAs in cell culture model of Parkinson\u2019s disease: relevance to \u03b1-synuclein misfolding in metal neurotoxicity. Neurotoxicology 64:267\u2013277. https:\/\/doi.org\/10.1016\/j.neuro.2017.04.007","journal-title":"Neurotoxicology"},{"key":"5522_CR123","doi-asserted-by":"publisher","DOI":"10.3389\/FCELL.2020.564641","author":"SY Chou","year":"2020","unstructured":"Chou SY, Chan L, Chung CC, Chiu JY, Hsieh YC, Hong CT (2020) Altered insulin receptor substrate 1 phosphorylation in blood neuron-derived extracellular vesicles from patients with parkinson\u2019s disease. Front Cell Dev Biol. https:\/\/doi.org\/10.3389\/FCELL.2020.564641","journal-title":"Front Cell Dev Biol"},{"key":"5522_CR124","doi-asserted-by":"publisher","first-page":"2136","DOI":"10.1002\/mds.29601","volume":"38","author":"I Markaki","year":"2023","unstructured":"Markaki I, Paslawski W, Ntetsika T, Engesvik L, Catrina S, Svenningsson P (2023) Isolation of <scp>L1CAM<\/scp> -extracellular vesicles reveals signs of insulin resistance in Parkinson\u2019s disease. Mov Disord 38:2136\u20132137. https:\/\/doi.org\/10.1002\/mds.29601","journal-title":"Mov Disord"},{"key":"5522_CR125","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12760","author":"F Bassil","year":"2022","unstructured":"Bassil F, Delamarre A, Canron M, Dutheil N, Vital A, N\u00e9grier-Leibreich M, Bezard E, Fernagut P, Meissner WG (2022) Impaired brain insulin signalling in Parkinson\u2019s disease. Neuropathol Appl Neurobiol. https:\/\/doi.org\/10.1111\/nan.12760","journal-title":"Neuropathol Appl Neurobiol"},{"key":"5522_CR126","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2020.134866","volume":"723","author":"B Leng","year":"2020","unstructured":"Leng B, Sun H, Zhao J, Liu Y, Shen T, Liu W, Liu X, Tan M, Li F, Zhang J, Li Z (2020) Plasma exosomal prion protein levels are correlated with cognitive decline in PD patients. Neurosci Lett 723:134866. https:\/\/doi.org\/10.1016\/j.neulet.2020.134866","journal-title":"Neurosci Lett"},{"key":"5522_CR127","doi-asserted-by":"publisher","first-page":"8022","DOI":"10.3390\/ijms22158022","volume":"22","author":"S Vascellari","year":"2021","unstructured":"Vascellari S, Manzin A (2021) Parkinson\u2019s disease: a prionopathy? Int J Mol Sci 22:8022. https:\/\/doi.org\/10.3390\/ijms22158022","journal-title":"Int J Mol Sci"},{"key":"5522_CR128","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000017478","volume":"98","author":"R Jiang","year":"2019","unstructured":"Jiang R, Rong C, Ke R, Meng S, Yan X, Ke H, Wu S (2019) Differential proteomic analysis of serum exosomes reveals alterations in progression of Parkinson disease. Medicine 98:e17478. https:\/\/doi.org\/10.1097\/MD.0000000000017478","journal-title":"Medicine"},{"key":"5522_CR129","doi-asserted-by":"publisher","first-page":"604","DOI":"10.3390\/cells10030604","volume":"10","author":"L Chan","year":"2021","unstructured":"Chan L, Chung CC, Chen JH, Yu RC, Hong CT (2021) Cytokine profile in plasma extracellular vesicles of Parkinson\u2019s disease and the association with cognitive function. Cells 10:604. https:\/\/doi.org\/10.3390\/cells10030604","journal-title":"Cells"},{"key":"5522_CR130","doi-asserted-by":"publisher","DOI":"10.18632\/aging.204575","author":"L Chan","year":"2023","unstructured":"Chan L, Chung CC, Yu RC, Hong CT (2023) Cytokine profiles of plasma extracellular vesicles as progression biomarkers in Parkinson\u2019s disease. Aging. https:\/\/doi.org\/10.18632\/aging.204575","journal-title":"Aging"},{"key":"5522_CR131","doi-asserted-by":"publisher","first-page":"504","DOI":"10.3390\/jcm9020504","volume":"9","author":"A Picca","year":"2020","unstructured":"Picca A, Guerra F, Calvani R, Marini F, Biancolillo A, Landi G, Beli R, Landi F, Bernabei R, Bentivoglio A, Lo Monaco M, Bucci C, Marzetti E (2020) Mitochondrial signatures in circulating extracellular vesicles of older adults with Parkinson\u2019s disease: results from the EXosomes in PArkiNson\u2019s disease (EXPAND) study. J Clin Med 9:504. https:\/\/doi.org\/10.3390\/jcm9020504","journal-title":"J Clin Med"},{"key":"5522_CR132","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/s00441-019-03128-1","volume":"379","author":"C Cocco","year":"2020","unstructured":"Cocco C, Corda G, Lisci C, Noli B, Carta M, Brancia C, Manca E, Masala C, Marrosu F, Solla P, Manconi B, Bongioanni P, Ferri GL (2020) VGF peptides as novel biomarkers in Parkinson\u2019s disease. Cell Tissue Res 379:93\u2013107. https:\/\/doi.org\/10.1007\/s00441-019-03128-1","journal-title":"Cell Tissue Res"},{"key":"5522_CR133","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2024.107603","volume":"300","author":"F Filippini","year":"2024","unstructured":"Filippini F, Galli T (2024) Unveiling defects of secretion mechanisms in Parkinson\u2019s disease. J Biol Chem 300:107603. https:\/\/doi.org\/10.1016\/j.jbc.2024.107603","journal-title":"J Biol Chem"},{"key":"5522_CR134","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1002\/mds.26686","volume":"31","author":"KB Fraser","year":"2016","unstructured":"Fraser KB, Rawlins AB, Clark RG, Alcalay RN, Standaert DG, Liu N, West AB (2016) Ser(P)-1292 LRRK2 in urinary exosomes is elevated in idiopathic Parkinson\u2019s disease. Mov Disord 31:1543\u20131550. https:\/\/doi.org\/10.1002\/mds.26686","journal-title":"Mov Disord"},{"key":"5522_CR135","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1038\/s41531-023-00445-9","volume":"9","author":"JM Taymans","year":"2023","unstructured":"Taymans JM, Mutez E, Sibran W, Vandewynckel L, Deldycke C, Bleuse S, Marchand A, Sarchione A, Leghay C, Kreisler A, Simonin C, Koprich J, Baille G, Defebvre L, Dujardin K, Dest\u00e9e A, Chartier-Harlin MC (2023) Alterations in the LRRK2-Rab pathway in urinary extracellular vesicles as Parkinson\u2019s disease and pharmacodynamic biomarkers. NPJ Parkinsons Dis 9:21. https:\/\/doi.org\/10.1038\/s41531-023-00445-9","journal-title":"NPJ Parkinsons Dis"},{"key":"5522_CR136","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/s40478-017-0492-y","volume":"5","author":"S Wang","year":"2017","unstructured":"Wang S, Liu Z, Ye T, Mabrouk OS, Maltbie T, Aasly J, West AB (2017) Elevated LRRK2 autophosphorylation in brain-derived and peripheral exosomes in LRRK2 mutation carriers. Acta Neuropathol Commun 5:86. https:\/\/doi.org\/10.1186\/s40478-017-0492-y","journal-title":"Acta Neuropathol Commun"},{"key":"5522_CR137","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2007.68","author":"IF Mata","year":"2008","unstructured":"Mata IF, Samii A, Schneer SH, Roberts JW, Griffith A, Leis BC, Schellenberg GD, Sidransky E, Bird TD, Leverenz JB, Tsuang D, Zabetian CP (2008) Glucocerebrosidase gene mutations. Arch Neurol. https:\/\/doi.org\/10.1001\/archneurol.2007.68","journal-title":"Arch Neurol"},{"key":"5522_CR138","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1008859","volume":"17","author":"KA Jewett","year":"2021","unstructured":"Jewett KA, Thomas RE, Phan CQ, Lin B, Milstein G, Yu S, Bettcher LF, Neto FC, Djukovic D, Raftery D, Pallanck LJ, Davis MY (2021) Glucocerebrosidase reduces the spread of protein aggregation in a drosophila melanogaster model of neurodegeneration by regulating proteins trafficked by extracellular vesicles. PLoS Genet 17:e1008859. https:\/\/doi.org\/10.1371\/journal.pgen.1008859","journal-title":"PLoS Genet"},{"key":"5522_CR139","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.neulet.2013.06.009","volume":"548","author":"C Chang","year":"2013","unstructured":"Chang C, Lang H, Geng N, Wang J, Li N, Wang X (2013) Exosomes of BV-2 cells induced by alpha-synuclein: Important mediator of neurodegeneration in PD. Neurosci Lett 548:190\u2013195. https:\/\/doi.org\/10.1016\/j.neulet.2013.06.009","journal-title":"Neurosci Lett"},{"key":"5522_CR140","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1089\/jir.2018.0155","volume":"39","author":"G Mahesh","year":"2019","unstructured":"Mahesh G, Biswas R (2019) MicroRNA-155: a master regulator of inflammation. J Interferon Cytokine Res 39:321\u2013330. https:\/\/doi.org\/10.1089\/jir.2018.0155","journal-title":"J Interferon Cytokine Res"},{"key":"5522_CR141","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1007\/s00401-018-1932-x","volume":"136","author":"JL Molinuevo","year":"2018","unstructured":"Molinuevo JL, Ayton S, Batrla R, Bednar MM, Bittner T, Cummings J, Fagan AM, Hampel H, Mielke MM, Mikulskis A, O\u2019Bryant S, Scheltens P, Sevigny J, Shaw LM, Soares HD, Tong G, Trojanowski JQ, Zetterberg H, Blennow K (2018) Current state of Alzheimer\u2019s fluid biomarkers. Acta Neuropathol 136:821\u2013853. https:\/\/doi.org\/10.1007\/s00401-018-1932-x","journal-title":"Acta Neuropathol"},{"key":"5522_CR142","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-024-02709-z","author":"TR Hunter","year":"2024","unstructured":"Hunter TR, Santos LE, Tovar-Moll F, De Felice FG (2024) Alzheimer\u2019s disease biomarkers and their current use in clinical research and practice. Mol Psychiatry. https:\/\/doi.org\/10.1038\/s41380-024-02709-z","journal-title":"Mol Psychiatry"},{"key":"5522_CR143","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1111\/ane.13698","volume":"146","author":"E Sturmey","year":"2022","unstructured":"Sturmey E, Malaspina A (2022) Blood biomarkers in <scp>ALS<\/scp>\u202f: challenges, applications and novel frontiers. Acta Neurol Scand 146:375\u2013388. https:\/\/doi.org\/10.1111\/ane.13698","journal-title":"Acta Neurol Scand"},{"key":"5522_CR144","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1007\/s00702-022-02498-1","volume":"129","author":"L T\u00f6nges","year":"2022","unstructured":"T\u00f6nges L, Buhmann C, Klebe S, Klucken J, Kwon EH, M\u00fcller T, Pedrosa DJ, Schr\u00f6ter N, Riederer P, Lingor P (2022) Blood-based biomarker in Parkinson\u2019s disease: potential for future applications in clinical research and practice. J Neural Transm 129:1201\u20131217. https:\/\/doi.org\/10.1007\/s00702-022-02498-1","journal-title":"J Neural Transm"},{"key":"5522_CR145","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2021.135914","volume":"755","author":"BI Arioz","year":"2021","unstructured":"Arioz BI, Tufekci KU, Olcum M, Durur DY, Akarlar BA, Ozlu N, Bagriyanik HA, Keskinoglu P, Yener G, Genc S (2021) Proteome profiling of neuron-derived exosomes in Alzheimer\u2019s disease reveals hemoglobin as a potential biomarker. Neurosci Lett 755:135914. https:\/\/doi.org\/10.1016\/j.neulet.2021.135914","journal-title":"Neurosci Lett"}],"container-title":["Cellular and Molecular Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-024-05522-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00018-024-05522-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-024-05522-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T20:03:01Z","timestamp":1733256181000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00018-024-05522-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":145,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["5522"],"URL":"https:\/\/doi.org\/10.1007\/s00018-024-05522-7","relation":{},"ISSN":["1420-682X","1420-9071"],"issn-type":[{"value":"1420-682X","type":"print"},{"value":"1420-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"18 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 October 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 November 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 December 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"R.J.P. reports to have sponsored research agreements with Amylyx.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"479"}}