{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T16:53:29Z","timestamp":1793379209814,"version":"4.5.0"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T00:00:00Z","timestamp":1740096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T00:00:00Z","timestamp":1740096000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"the Natural Science Foundation of Xinjiang Autonomous Region","award":["2021D01C164"],"award-info":[{"award-number":["2021D01C164"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell. Mol. Life Sci."],"DOI":"10.1007\/s00018-025-05592-1","type":"journal-article","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T15:31:21Z","timestamp":1740151881000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["FOXO regulation of TXNIP induces ferroptosis in satellite cells by inhibiting glutathione metabolism, promoting Sarcopenia"],"prefix":"10.1007","volume":"82","author":[{"given":"Yasenjiang","family":"Maimaiti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukedasi","family":"Abulitifu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zulifeiya","family":"Ajimu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhichao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0561-5026","authenticated-orcid":false,"given":"Hong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,21]]},"reference":[{"key":"5592_CR1","doi-asserted-by":"crossref","unstructured":"He N, Zhang Y, Zhang L, et al (2021) Relationship between Sarcopenia and cardiovascular diseases in the elderly: an overview. Front Cardiovasc Med. 8: 743710","DOI":"10.3389\/fcvm.2021.743710"},{"key":"5592_CR2","doi-asserted-by":"publisher","first-page":"8396","DOI":"10.3390\/ijms23158396","volume":"23","author":"M Kanova","year":"2022","unstructured":"Kanova M, Kohout P (2022) Molecular mechanisms underlying intensive care unit-acquired weakness and Sarcopenia. IJMS 23:8396","journal-title":"IJMS"},{"key":"5592_CR3","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1093\/ageing\/afy169","volume":"48","author":"AJ Cruz-Jentoft","year":"2018","unstructured":"Cruz-Jentoft AJ, Bahat G, Bauer J et al (2018) Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing 48:16\u201331","journal-title":"Age Ageing"},{"key":"5592_CR4","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/j.jamda.2019.12.012","volume":"21","author":"L-K Chen","year":"2020","unstructured":"Chen L-K, Woo J, Assantachai P et al (2020) Asian Working Group for Sarcopenia: 2019 consensus update on sarcopenia diagnosis and treatment. J Am Med Dir Assoc 21:300-307.e2","journal-title":"J Am Med Dir Assoc"},{"key":"5592_CR5","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1007\/s00508-016-1087-5","volume":"128","author":"JE Morley","year":"2016","unstructured":"Morley JE (2016) Frailty and sarcopenia in elderly. Wien Klin Wochenschr 128:439\u2013445","journal-title":"Wien Klin Wochenschr"},{"key":"5592_CR6","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.cger.2016.08.002","volume":"33","author":"RJS Dhillon","year":"2017","unstructured":"Dhillon RJS, Hasni S (2017) Pathogenesis and management of Sarcopenia. Clin Geriatr Med 33:17\u201326","journal-title":"Clin Geriatr Med"},{"key":"5592_CR7","doi-asserted-by":"publisher","first-page":"882","DOI":"10.52586\/4995","volume":"26","author":"Y Shi","year":"2021","unstructured":"Shi Y, Zhou L, Yan E et al (2021) Sarcopenia and perioperative management of elderly surgical patients. Front Biosci (Landmark Ed) 26:882","journal-title":"Front Biosci (Landmark Ed)"},{"key":"5592_CR8","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1111\/age.13024","volume":"52","author":"K Doro\u017cy\u0144ska","year":"2020","unstructured":"Doro\u017cy\u0144ska K, Maj D (2020) Rabbits\u2014their domestication and molecular genetics of hair coat development and quality. Anim Genet 52:10\u201320","journal-title":"Anim Genet"},{"key":"5592_CR9","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1002\/ctm2.694","volume":"12","author":"D Jovic","year":"2022","unstructured":"Jovic D, Liang X, Zeng H et al (2022) Single-cell RNA sequencing technologies and applications: a brief overview. Clin Transl Med 12:694","journal-title":"Clin Transl Med"},{"key":"5592_CR10","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1016\/j.molcel.2015.04.005","volume":"58","author":"AA Kolodziejczyk","year":"2015","unstructured":"Kolodziejczyk AA, Kim JK, Svensson V et al (2015) The technology and biology of single-cell RNA sequencing. Mol Cell 58:610\u2013620","journal-title":"Mol Cell"},{"key":"5592_CR11","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1080\/10410236.2022.2163108","volume":"39","author":"W Lu","year":"2022","unstructured":"Lu W, Ngai CSB, Yi L (2022) A bibliometric review of constituents, themes, and trends in online medical consultation research. Health Commun 39:229\u2013243","journal-title":"Health Commun"},{"key":"5592_CR12","first-page":"1","volume":"2022","author":"M Pan","year":"2022","unstructured":"Pan M, Zhang F, Qu K et al (2022) TXNIP: a double-edged sword in disease and therapeutic outlook. Oxid Med Cell Longev 2022:1\u201314","journal-title":"Oxid Med Cell Longev"},{"key":"5592_CR13","doi-asserted-by":"publisher","first-page":"108767","DOI":"10.1016\/j.celrep.2021.108767","volume":"34","author":"X Song","year":"2021","unstructured":"Song X, Liu J, Kuang F et al (2021) PDK4 dictates metabolic resistance to ferroptosis by suppressing pyruvate oxidation and fatty acid synthesis. Cell Rep 34:108767","journal-title":"Cell Rep"},{"key":"5592_CR14","doi-asserted-by":"publisher","first-page":"6287","DOI":"10.4049\/jimmunol.164.12.6287","volume":"164","author":"E Junn","year":"2000","unstructured":"Junn E, Han SH, Im JY et al (2000) Vitamin D3 up-regulated protein 1 mediates oxidative stress via suppressing the thioredoxin function. J Immunol 164:6287\u20136295","journal-title":"J Immunol"},{"key":"5592_CR15","doi-asserted-by":"publisher","first-page":"21645","DOI":"10.1074\/jbc.274.31.21645","volume":"274","author":"A Nishiyama","year":"1999","unstructured":"Nishiyama A, Matsui M, Iwata S et al (1999) Identification of Thioredoxin-binding Protein-2\/Vitamin D3 Up-regulated protein 1 as a negative regulator of thioredoxin function and expression. J Biol Chem 274:21645\u201321650","journal-title":"J Biol Chem"},{"key":"5592_CR16","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1038\/cr.2015.139","volume":"25","author":"W He","year":"2015","unstructured":"He W, Wan H, Hu L et al (2015) Gasdermin D is an executor of pyroptosis and required for interleukin-1\u03b2 secretion. Cell Res 25:1285\u20131298","journal-title":"Cell Res"},{"key":"5592_CR17","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.cmet.2012.07.005","volume":"16","author":"CM Oslowski","year":"2012","unstructured":"Oslowski CM, Hara T, O\u2019Sullivan-Murphy B et al (2012) Thioredoxin-interacting protein mediates ER stress-induced \u03b2 cell death through initiation of the inflammasome. Cell Metab 16:265\u2013273","journal-title":"Cell Metab"},{"key":"5592_CR18","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1038\/s12276-023-01019-8","volume":"55","author":"E-H Choi","year":"2023","unstructured":"Choi E-H, Park S-J (2023) TXNIP: a key protein in the cellular stress response pathway and a potential therapeutic target. Exp Mol Med 55:1348\u20131356","journal-title":"Exp Mol Med"},{"key":"5592_CR19","doi-asserted-by":"publisher","first-page":"111475","DOI":"10.1016\/j.mad.2021.111475","volume":"196","author":"Q He","year":"2021","unstructured":"He Q, Li Y, Zhang W et al (2021) Role and mechanism of TXNIP in ageing-related renal fibrosis. Mech Ageing Dev 196:111475","journal-title":"Mech Ageing Dev"},{"key":"5592_CR20","doi-asserted-by":"publisher","first-page":"8106","DOI":"10.1074\/jbc.M113.511535","volume":"289","author":"KL DeBalsi","year":"2014","unstructured":"DeBalsi KL, Wong KE, Koves TR et al (2014) Targeted metabolomics connects thioredoxin-interacting protein (TXNIP) to mitochondrial fuel selection and regulation of specific oxidoreductase enzymes in skeletal muscle. J Biol Chem 289:8106\u20138120","journal-title":"J Biol Chem"},{"key":"5592_CR21","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s13059-019-1850-9","volume":"21","author":"HTN Tran","year":"2020","unstructured":"Tran HTN, Ang KS, Chevrier M et al (2020) A benchmark of batch-effect correction methods for single-cell RNA sequencing data. Genome Biol 21:12","journal-title":"Genome Biol"},{"key":"5592_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2020\/9431560","volume":"2020","author":"L Liang","year":"2020","unstructured":"Liang L, Zhu J, Chen G et al (2020) Prognostic values for the mRNA expression of the ADAMTS family of genes in gastric cancer. J Oncol 2020:1\u201324","journal-title":"J Oncol"},{"key":"5592_CR23","doi-asserted-by":"publisher","first-page":"2152","DOI":"10.1002\/jcsm.13292","volume":"14","author":"L Wang","year":"2023","unstructured":"Wang L, Gao P, Li C et al (2023) A single-cell atlas of bovine skeletal muscle reveals mechanisms regulating intramuscular adipogenesis and fibrogenesis. J Cachexia Sarcopenia Muscle 14:2152\u20132167","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"5592_CR24","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.ygeno.2021.12.011","volume":"114","author":"H Yang","year":"2022","unstructured":"Yang H, Tian W, Zhou B (2022) Sarcopenia and a 5-mRNA risk module as a combined factor to predict prognosis for patients with stomach adenocarcinoma. Genomics 114:361\u2013377","journal-title":"Genomics"},{"key":"5592_CR25","doi-asserted-by":"publisher","first-page":"102033","DOI":"10.1016\/j.redox.2021.102033","volume":"45","author":"X Dai","year":"2021","unstructured":"Dai X, Liao R, Liu C et al (2021) Epigenetic regulation of TXNIP-mediated oxidative stress and NLRP3 inflammasome activation contributes to SAHH inhibition-aggravated diabetic nephropathy. Redox Biol 45:102033","journal-title":"Redox Biol"},{"key":"5592_CR26","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.1016\/j.stem.2022.07.009","volume":"29","author":"X Hong","year":"2022","unstructured":"Hong X, Isern J, Campanario S et al (2022) Mitochondrial dynamics maintain muscle stem cell regenerative competence throughout adult life by regulating metabolism and mitophagy. Cell Stem Cell 29:1298-1314.e10","journal-title":"Cell Stem Cell"},{"key":"5592_CR27","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1038\/s41419-019-2089-9","volume":"10","author":"Z Liu","year":"2019","unstructured":"Liu Z, Yu Y, Huang Z et al (2019) CircRNA-5692 inhibits the progression of hepatocellular carcinoma by sponging miR-328-5p to enhance DAB2IP expression. Cell Death Dis 10:900","journal-title":"Cell Death Dis"},{"key":"5592_CR28","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.bbi.2020.12.009","volume":"92","author":"M Franke","year":"2021","unstructured":"Franke M, Bieber M, Kraft P et al (2021) The NLRP3 inflammasome drives inflammation in ischemia\/reperfusion injury after transient middle cerebral artery occlusion in mice. Brain Behav Immun 92:221\u2013231","journal-title":"Brain Behav Immun"},{"key":"5592_CR29","doi-asserted-by":"publisher","first-page":"113983","DOI":"10.1016\/j.bcp.2020.113983","volume":"177","author":"Z Peng","year":"2020","unstructured":"Peng Z, Li M, Tan X et al (2020) miR-211-5p alleviates focal cerebral ischemia-reperfusion injury in rats by down-regulating the expression of COX2. Biochem Pharmacol 177:113983","journal-title":"Biochem Pharmacol"},{"key":"5592_CR30","doi-asserted-by":"publisher","first-page":"e3080","DOI":"10.1038\/cddis.2017.465","volume":"8","author":"L Gong","year":"2017","unstructured":"Gong L, Tang Y, An R et al (2017) RTN1-C mediates cerebral ischemia\/reperfusion injury via ER stress and mitochondria-associated apoptosis pathways. Cell Death Dis 8:e3080\u2013e3080","journal-title":"Cell Death Dis"},{"key":"5592_CR31","doi-asserted-by":"publisher","first-page":"1540","DOI":"10.1038\/s41590-020-0793-3","volume":"21","author":"Y-R Yu","year":"2020","unstructured":"Yu Y-R, Imrichova H, Wang H et al (2020) Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion. Nat Immunol 21:1540\u20131551","journal-title":"Nat Immunol"},{"key":"5592_CR32","doi-asserted-by":"publisher","first-page":"8961","DOI":"10.1096\/fj.201900077R","volume":"33","author":"M Guerrero-Hue","year":"2019","unstructured":"Guerrero-Hue M, Garc\u00eda-Caballero C, Palomino-Antol\u00edn A et al (2019) Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death. FASEB J 33:8961\u20138975","journal-title":"FASEB J"},{"key":"5592_CR33","doi-asserted-by":"publisher","first-page":"2339","DOI":"10.1172\/JCI96208","volume":"128","author":"L Xie","year":"2018","unstructured":"Xie L, Yin A, Nichenko AS et al (2018) Transient HIF2A inhibition promotes satellite cell proliferation and muscle regeneration. J Clin Investig 128:2339\u20132355","journal-title":"J Clin Investig"},{"key":"5592_CR34","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1002\/jgm.2675","volume":"14","author":"M Robert","year":"2012","unstructured":"Robert M, Lin Y, Bendjelloul M et al (2012) Strength and muscle specificity of a compact promoter derived from the slow troponin I gene in the context of episomal (gutless adenovirus) and integrating (lentiviral) vectors. J Gene Med 14:746\u2013760","journal-title":"J Gene Med"},{"key":"5592_CR35","doi-asserted-by":"publisher","first-page":"14165","DOI":"10.1111\/apha.14165","volume":"240","author":"E Passerieux","year":"2024","unstructured":"Passerieux E, Desplanche E, Alburquerque L et al (2024) Altered skeletal muscle function and beneficial effects of exercise training in a rat model of induced pulmonary emphysema. Acta Physiol 240:14165","journal-title":"Acta Physiol"},{"key":"5592_CR36","doi-asserted-by":"publisher","first-page":"6228","DOI":"10.1038\/s41598-019-42370-z","volume":"9","author":"T Imai","year":"2019","unstructured":"Imai T, Iwata S, Hirayama T et al (2019) Intracellular Fe2+ accumulation in endothelial cells and pericytes induces blood-brain barrier dysfunction in secondary brain injury after brain hemorrhage. Sci Rep 9:6228","journal-title":"Sci Rep"},{"key":"5592_CR37","doi-asserted-by":"publisher","first-page":"102014","DOI":"10.1016\/j.arr.2023.102014","volume":"90","author":"P-T Tseng","year":"2023","unstructured":"Tseng P-T, Zeng B-Y, Zeng B-S et al (2023) Omega-3 polyunsaturated fatty acids in sarcopenia management: a network meta-analysis of randomized controlled trials. Ageing Res Rev 90:102014","journal-title":"Ageing Res Rev"},{"key":"5592_CR38","doi-asserted-by":"publisher","first-page":"8816","DOI":"10.1021\/acs.nanolett.3c01502","volume":"23","author":"X Yu","year":"2023","unstructured":"Yu X, Wang Y, Ran L et al (2023) Tetrahedral framework nucleic acids inhibit muscular mitochondria-mediated apoptosis and ameliorate muscle atrophy in sarcopenia. Nano Lett 23:8816\u20138826","journal-title":"Nano Lett"},{"key":"5592_CR39","doi-asserted-by":"publisher","first-page":"10064","DOI":"10.4081\/ejtm.2022.10064","volume":"32","author":"M Ganassi","year":"2022","unstructured":"Ganassi M, Zammit PS (2022) Involvement of muscle satellite cell dysfunction in neuromuscular disorders: expanding the portfolio of satellite cell-opathies. Eur J Transl Myol 32:10064","journal-title":"Eur J Transl Myol"},{"key":"5592_CR40","doi-asserted-by":"publisher","first-page":"110939","DOI":"10.1016\/j.celrep.2022.110939","volume":"39","author":"J Zheng","year":"2022","unstructured":"Zheng J, Lou J, Li Y et al (2022) Satellite cell-specific deletion of Cipc alleviates myopathy in mdx mice. Cell Rep 39:110939","journal-title":"Cell Rep"},{"key":"5592_CR41","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1002\/jcsm.12937","volume":"13","author":"L Gonz\u00e1lez-Blanco","year":"2022","unstructured":"Gonz\u00e1lez-Blanco L, Berm\u00fadez M, Bermejo-Millo JC et al (2022) Cell interactome in sarcopenia during aging. J Cachexia Sarcopenia Muscle 13:919\u2013931","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"5592_CR42","doi-asserted-by":"publisher","first-page":"6097","DOI":"10.3390\/ijms24076097","volume":"24","author":"S Mankhong","year":"2023","unstructured":"Mankhong S, Kim S, Moon S et al (2023) Melatonin and exercise counteract sarcopenic obesity through preservation of satellite cell function. IJMS 24:6097","journal-title":"IJMS"},{"key":"5592_CR43","doi-asserted-by":"publisher","first-page":"E542","DOI":"10.1152\/ajpendo.00270.2022","volume":"324","author":"H Abuduwaili","year":"2023","unstructured":"Abuduwaili H, Kamoshita K, Ishii K et al (2023) Selenoprotein P deficiency protects against immobilization-induced muscle atrophy by suppressing atrophy-related E3 ubiquitin ligases. Am J Physiol Endocrinol Metabol 324:E542\u2013E552","journal-title":"Am J Physiol Endocrinol Metabol"},{"key":"5592_CR44","doi-asserted-by":"publisher","first-page":"5665","DOI":"10.1038\/s41467-022-33008-2","volume":"13","author":"T Sasako","year":"2022","unstructured":"Sasako T, Umehara T, Soeda K et al (2022) Deletion of skeletal muscle Akt1\/2 causes osteosarcopenia and reduces lifespan in mice. Nat Commun 13:5665","journal-title":"Nat Commun"},{"key":"5592_CR45","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1089\/ars.2019.7905","volume":"33","author":"R Brigelius-Floh\u00e9","year":"2020","unstructured":"Brigelius-Floh\u00e9 R, Floh\u00e9 L (2020) Regulatory phenomena in the glutathione peroxidase superfamily. Antioxid Redox Signal 33:498\u2013516","journal-title":"Antioxid Redox Signal"},{"key":"5592_CR46","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1089\/ars.2021.0199","volume":"36","author":"FT Ogata","year":"2022","unstructured":"Ogata FT, Sim\u00f5es Sato AY, Coppo L et al (2022) Thiol-based antioxidants and the epithelial\/mesenchymal transition in cancer. Antioxid Redox Signal 36:1037\u20131050","journal-title":"Antioxid Redox Signal"},{"key":"5592_CR47","doi-asserted-by":"publisher","first-page":"2549","DOI":"10.1080\/15548627.2020.1834711","volume":"17","author":"H-S Park","year":"2020","unstructured":"Park H-S, Song J-W, Park J-H et al (2020) TXNIP\/VDUP1 attenuates steatohepatitis via autophagy and fatty acid oxidation. Autophagy 17:2549\u20132564","journal-title":"Autophagy"},{"key":"5592_CR48","doi-asserted-by":"publisher","first-page":"102218","DOI":"10.1016\/j.isci.2021.102218","volume":"24","author":"B Noblet","year":"2021","unstructured":"Noblet B, Benhamed F, O-Sullivan I, et al (2021) Dual regulation of TxNIP by ChREBP and FoxO1 in liver. iScience 24:102218","journal-title":"iScience"},{"key":"5592_CR49","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1016\/j.jcmgh.2020.10.006","volume":"11","author":"L Zhang","year":"2021","unstructured":"Zhang L, Zhang Z, Li C et al (2021) S100A11 promotes liver steatosis via FOXO1-mediated autophagy and lipogenesis. Cell Mol Gastroenterol Hepatol 11:697\u2013724","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"5592_CR50","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s11658-017-0040-6","volume":"22","author":"X Xu","year":"2017","unstructured":"Xu X, Ji S, Li W et al (2017) LncRNA H19 promotes the differentiation of bovine skeletal muscle satellite cells by suppressing Sirt1\/FoxO1. Cell Mol Biol Lett 22:10","journal-title":"Cell Mol Biol Lett"},{"key":"5592_CR51","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1038\/s41580-021-00421-2","volume":"23","author":"P Sousa-Victor","year":"2021","unstructured":"Sousa-Victor P, Garc\u00eda-Prat L, Mu\u00f1oz-C\u00e1noves P (2021) Control of satellite cell function in muscle regeneration and its disruption in ageing. Nat Rev Mol Cell Biol 23:204\u2013226","journal-title":"Nat Rev Mol Cell Biol"},{"key":"5592_CR52","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1002\/cphy.c140068","volume":"5","author":"NA Dumont","year":"2015","unstructured":"Dumont NA, Bentzinger CF, Sincennes M, Rudnicki MA (2015) Satellite cells and skeletal muscle regeneration. Comprehens Physiol 5:1027\u20131059","journal-title":"Comprehens Physiol"},{"key":"5592_CR53","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1152\/physrev.00043.2011","volume":"93","author":"H Yin","year":"2013","unstructured":"Yin H, Price F, Rudnicki MA (2013) satellite cells and the muscle stem cell niche. Physiol Rev 93:23\u201367","journal-title":"Physiol Rev"},{"key":"5592_CR54","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1038\/s42255-021-00483-8","volume":"3","author":"CD Wiley","year":"2021","unstructured":"Wiley CD, Campisi J (2021) The metabolic roots of senescence: mechanisms and opportunities for intervention. Nat Metab 3:1290\u20131301","journal-title":"Nat Metab"},{"key":"5592_CR55","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1111\/febs.16361","volume":"290","author":"H Martini","year":"2022","unstructured":"Martini H, Passos JF (2022) Cellular senescence: all roads lead to mitochondria. FEBS J 290:1186\u20131202","journal-title":"FEBS J"},{"key":"5592_CR56","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1038\/s41556-020-00593-7","volume":"22","author":"L Garc\u00eda-Prat","year":"2020","unstructured":"Garc\u00eda-Prat L, Perdiguero E, Alonso-Mart\u00edn S et al (2020) FoxO maintains a genuine muscle stem-cell quiescent state until geriatric age. Nat Cell Biol 22:1307\u20131318","journal-title":"Nat Cell Biol"},{"key":"5592_CR57","doi-asserted-by":"publisher","first-page":"115900","DOI":"10.1016\/j.biopha.2023.115900","volume":"169","author":"M Ebrahimnezhad","year":"2023","unstructured":"Ebrahimnezhad M, Natami M, Bakhtiari GH et al (2023) FOXO1, a tiny protein with intricate interactions: promising therapeutic candidate in lung cancer. Biomed Pharmacother 169:115900","journal-title":"Biomed Pharmacother"}],"container-title":["Cellular and Molecular Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-025-05592-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00018-025-05592-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-025-05592-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T15:33:57Z","timestamp":1740152037000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00018-025-05592-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,21]]},"references-count":57,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["5592"],"URL":"https:\/\/doi.org\/10.1007\/s00018-025-05592-1","relation":{},"ISSN":["1420-9071"],"issn-type":[{"value":"1420-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,21]]},"assertion":[{"value":"29 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 December 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 January 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 February 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}],"article-number":"81"}}