{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T16:52:10Z","timestamp":1784307130289,"version":"3.55.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:00:00Z","timestamp":1743984000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:00:00Z","timestamp":1743984000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20242BAB25539"],"award-info":[{"award-number":["20242BAB25539"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020205","name":"Health Commission of Jiangxi Province","doi-asserted-by":"publisher","award":["202310009"],"award-info":[{"award-number":["202310009"]}],"id":[{"id":"10.13039\/501100020205","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell. Mol. Life Sci."],"DOI":"10.1007\/s00018-025-05657-1","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T11:59:33Z","timestamp":1744027173000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Dietary advanced glycation end-products exacerbate sarcopenia onset by activating apoptosis through PRMT1-mediated CRTC3 arginine methylation"],"prefix":"10.1007","volume":"82","author":[{"given":"Tian-Jin","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang-Jingsi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Na","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8388-8878","authenticated-orcid":false,"given":"Fa-Xiu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,7]]},"reference":[{"key":"5657_CR1","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.3390\/nu12051293","volume":"12","author":"SK Papadopoulou","year":"2020","unstructured":"Papadopoulou SK (2020) Sarcopenia: A contemporary health problem among older adult populations. Nutrients 12:1293","journal-title":"Nutrients"},{"key":"5657_CR2","doi-asserted-by":"crossref","first-page":"101200","DOI":"10.1016\/j.arr.2020.101200","volume":"65","author":"P Wiedmer","year":"2021","unstructured":"Wiedmer P, Jung T, Castro JP, Pomatto LCD, Sun PY, Davies KJA et al (2021) Sarcopenia\u2013 Molecular mechanisms and open questions. Ageing Res Rev 65:101200","journal-title":"Ageing Res Rev"},{"key":"5657_CR3","doi-asserted-by":"crossref","first-page":"143","DOI":"10.4014\/jmb.2210.10014","volume":"33","author":"YJ Jang","year":"2023","unstructured":"Jang YJ (2023) The effects of protein and supplements on sarcopenia in human clinical studies: how older adults should consume protein and supplements. J Microbiol Biotechnol 33:143\u2013150","journal-title":"J Microbiol Biotechnol"},{"key":"5657_CR4","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.maturitas.2021.01.002","volume":"145","author":"NK Gkekas","year":"2021","unstructured":"Gkekas NK, Anagnostis P, Paraschou V, Stamiris D, Dellis S, Kenanidis E et al (2021) The effect of vitamin D plus protein supplementation on sarcopenia: A systematic review and meta-analysis of randomized controlled trials. Maturitas 145:56\u201363","journal-title":"Maturitas"},{"key":"5657_CR5","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.3390\/nu15173703","volume":"15","author":"C Cochet","year":"2023","unstructured":"Cochet C, Belloni G, Buondonno I, Chiara F, D\u2019Amelio P (2023) The role of nutrition in the treatment of sarcopenia in old patients: from restoration of mitochondrial activity to improvement of muscle performance, a systematic review. Nutrients 15:3703","journal-title":"Nutrients"},{"key":"5657_CR6","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.3390\/biomedicines11061635","volume":"11","author":"JY Jang","year":"2023","unstructured":"Jang JY, Kim D, Kim ND (2023) Pathogenesis, intervention, and current status of drug development for sarcopenia: A review. Biomedicines 11:1635","journal-title":"Biomedicines"},{"key":"5657_CR7","doi-asserted-by":"crossref","first-page":"4300","DOI":"10.3390\/ijms25084300","volume":"25","author":"A Najm","year":"2024","unstructured":"Najm A, Niculescu AG, Grumezescu AM, Beuran M (2024) Emerging therapeutic strategies in sarcopenia: an updated review on pathogenesis and treatment advances. Int J Mol Sci 25:4300","journal-title":"Int J Mol Sci"},{"key":"5657_CR8","doi-asserted-by":"crossref","first-page":"155597","DOI":"10.1016\/j.metabol.2023.155597","volume":"149","author":"Y Rolland","year":"2023","unstructured":"Rolland Y, Dray C, Vellas B, Barreto PS (2023) Current and investigational medications for the treatment of sarcopenia. Metabolism 149:155597","journal-title":"Metabolism"},{"key":"5657_CR9","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.3390\/cells11081312","volume":"11","author":"A Twarda-Clapa","year":"2022","unstructured":"Twarda-Clapa A, Olczak A, Bialkowska AM, Koziolkiewicz M (2022) Advanced glycation end-products (AGEs): formation, chemistry, classification, receptors, and diseases related to ages. Cells 11:1312","journal-title":"Cells"},{"key":"5657_CR10","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1177\/1559827617708991","volume":"13","author":"C Prasad","year":"2019","unstructured":"Prasad C, Davis KE, Imrhan V, Juma S, Vijayagopal P (2019) Advanced glycation end-products and risks for chronic diseases: intervening through lifestyle modification. Am J Lifestyle Med 13:384\u2013404","journal-title":"Am J Lifestyle Med"},{"key":"5657_CR11","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s12551-024-01188-4","volume":"16","author":"AB Uceda","year":"2024","unstructured":"Uceda AB, Marino L, Casasnovas R, Adrover M (2024) An overview on glycation: molecular mechanisms, impact on proteins, pathogenesis, and Inhibition. Biophys Rev 16:189\u2013218","journal-title":"Biophys Rev"},{"key":"5657_CR12","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1038\/s12276-021-00613-y","volume":"53","author":"JW Hwang","year":"2021","unstructured":"Hwang JW, Cho Y, Bae GU, Kim SN, Kim YK (2021) Protein arginine methyltransferases: promising targets for cancer therapy. Exp Mol Med 53:788\u2013808","journal-title":"Exp Mol Med"},{"key":"5657_CR13","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.molcel.2005.04.003","volume":"18","author":"MT Bedford","year":"2005","unstructured":"Bedford MT, Richard S (2005) Arginine methylation an emerging regulator of protein function. Mol Cell 18:263\u2013272","journal-title":"Mol Cell"},{"key":"5657_CR14","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.molcel.2016.11.003","volume":"65","author":"RS Blanc","year":"2017","unstructured":"Blanc RS, Richard S (2017) Arginine methylation: the coming of age. Mol Cell 65:8\u201324","journal-title":"Mol Cell"},{"key":"5657_CR15","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s11658-024-00618-1","volume":"29","author":"W Liang","year":"2024","unstructured":"Liang W, Xu F, Li L, Peng C, Sun H, Qiu J et al (2024) Epigenetic control of skeletal muscle atrophy. Cell Mol Biol Lett 29:99","journal-title":"Cell Mol Biol Lett"},{"key":"5657_CR16","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1080\/15548627.2019.1569931","volume":"15","author":"S Choi","year":"2019","unstructured":"Choi S, Jeong HJ, Kim H, Choi D, Cho SC, Seong JK et al (2019) Skeletal muscle-specific Prmt1 deletion causes muscle atrophy via deregulation of the PRMT6-FOXO3 axis. Autophagy 15:1069\u20131081","journal-title":"Autophagy"},{"key":"5657_CR17","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.2337\/db15-1500","volume":"65","author":"HJ Jeong","year":"2016","unstructured":"Jeong HJ, Lee HJ, Vuong TA, Choi KS, Choi D, Koo SH et al (2016) Prmt7 deficiency causes reduced skeletal muscle oxidative metabolism and Age-Related obesity. Diabetes 65:1868\u20131882","journal-title":"Diabetes"},{"key":"5657_CR18","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nature18014","volume":"534","author":"HJ Shin","year":"2016","unstructured":"Shin HJ, Kim H, Oh S, Lee JG, Kee M, Ko HJ et al (2016) AMPK-SKP2-CARM1 signalling cascade in transcriptional regulation of autophagy. Nature 534:553\u2013557","journal-title":"Nature"},{"key":"5657_CR19","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/01926230701320337","volume":"35","author":"S Elmore","year":"2007","unstructured":"Elmore S (2007) Apoptosis: A review of programmed cell death. Toxicol Pathol 35:495\u2013516","journal-title":"Toxicol Pathol"},{"key":"5657_CR20","doi-asserted-by":"crossref","first-page":"a006080","DOI":"10.1101\/cshperspect.a006080","volume":"7","author":"DR Green","year":"2015","unstructured":"Green DR, Llambi F (2015) Cell death signaling. Cold Spring Harb Perspect Biol 7:a006080","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"5657_CR21","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/j.exger.2006.08.011","volume":"41","author":"E Marzetti","year":"2006","unstructured":"Marzetti E, Leeuwenburgh C (2006) Skeletal muscle apoptosis, sarcopenia and frailty at old age. Exp Gerontol 41:1234\u20131238","journal-title":"Exp Gerontol"},{"key":"5657_CR22","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1159\/000330064","volume":"58","author":"E Marzetti","year":"2012","unstructured":"Marzetti E, Calvani R, Bernabei R, Leeuwenburgh C (2012) Apoptosis in skeletal myocytes: A potential target for interventions against sarcopenia and physical frailty\u2013 A mini-review. Gerontology 58:99\u2013106","journal-title":"Gerontology"},{"key":"5657_CR23","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1111\/acel.12399","volume":"14","author":"N Cheema","year":"2015","unstructured":"Cheema N, Herbst A, McKenzie D, Aiken JM (2015) Apoptosis and necrosis mediate skeletal muscle fiber loss in age-induced mitochondrial enzymatic abnormalities. Aging Cell 14:1085\u20131093","journal-title":"Aging Cell"},{"key":"5657_CR24","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/acel.12169","volume":"13","author":"H Wang","year":"2014","unstructured":"Wang H, Listrat A, Meunier B, Gueugneau M, Coudy-Gandilhon C, Combaret L et al (2014) Apoptosis in capillary endothelial cells in ageing skeletal muscle. Aging Cell 13:254\u2013262","journal-title":"Aging Cell"},{"key":"5657_CR25","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/jgh.12042","volume":"28","author":"M Goodwin","year":"2013","unstructured":"Goodwin M, Herath C, Jia Z, Leung C, Coughlan MT, Forbes J et al (2013) Advanced glycation end-products augment experimental hepatic fibrosis. J Gastroenterol Hepatol 28:369\u2013376","journal-title":"J Gastroenterol Hepatol"},{"key":"5657_CR26","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.3390\/biomedicines11102708","volume":"11","author":"YC Liang","year":"2023","unstructured":"Liang YC, Cheng KP, Kuo HY, Wang CT, Chou HW, Huang KL et al (2023) Calsarcin-2 May play a compensatory role in the development of obese sarcopenia. Biomedicines 11:2708","journal-title":"Biomedicines"},{"key":"5657_CR27","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3390\/antiox9040329","volume":"9","author":"F Pacifici","year":"2020","unstructured":"Pacifici F, Della-Morte D, Piermarini F, Arriga R, Scioli MG, Capuani B et al (2020) Prdx6 plays a main role in the crosstalk between aging and metabolic sarcopenia. Antioxid (Basel) 9:329","journal-title":"Antioxid (Basel)"},{"key":"5657_CR28","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1002\/jcsm.12560","volume":"11","author":"GK Shang","year":"2020","unstructured":"Shang GK, Han L, Wang ZH, Liu YP, Yan SB, Sai WW et al (2020) Sarcopenia is attenuated by TRB3 knockout in aging mice via the alleviation of atrophy and fibrosis of skeletal muscles. J Cachexia Sarcopenia Muscle 11:1104\u20131120","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"5657_CR29","doi-asserted-by":"crossref","first-page":"3974","DOI":"10.1158\/0008-5472.CAN-22-0800","volume":"82","author":"H Liu","year":"2022","unstructured":"Liu H, Lyu H, Jiang G, Chen D, Ruan S, Liu S et al (2022) ALKBH5-Mediated m6A demethylation of GLUT4 mRNA promotes Glycolysis and resistance to HER2-Targeted therapy in breast cancer. Cancer Res 82:3974\u20133986","journal-title":"Cancer Res"},{"key":"5657_CR30","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.joca.2023.09.005","volume":"32","author":"C Tseng","year":"2024","unstructured":"Tseng C, Chen B, Han Y, Wang K, Song Q, Shen H et al (2024) Advanced glycation end-products promote intervertebral disc degeneration by transactivation of matrix metallopeptidase genes. Osteoarthritis Cartilage 32:187\u2013199","journal-title":"Osteoarthritis Cartilage"},{"key":"5657_CR31","doi-asserted-by":"crossref","first-page":"111744","DOI":"10.1016\/j.mad.2022.111744","volume":"209","author":"A Granic","year":"2023","unstructured":"Granic A, Hurst C, Dismore L, Dodds RM, Witham MD, Robinson SM et al (2023) Advanced glycation end-products in skeletal muscle health and sarcopenia: A systematic review of observational studies. Mech Ageing Dev 209:111744","journal-title":"Mech Ageing Dev"},{"key":"5657_CR32","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.3390\/biomedicines10071489","volume":"10","author":"P Molinari","year":"2022","unstructured":"Molinari P, Caldiroli L, Dozio E, Rigolini R, Giubbilini P, Corsi Romanelli MM et al (2022) Association between advanced glycation end-products and sarcopenia in patients with chronic kidney disease. Biomedicines 10:1489","journal-title":"Biomedicines"},{"key":"5657_CR33","doi-asserted-by":"crossref","first-page":"e1105","DOI":"10.1210\/clinem\/dgad640","volume":"109","author":"X Zhang","year":"2024","unstructured":"Zhang X, Chen X, Li S, Gao M, Han P, Cao L et al (2024) Association between advanced glycation end-products and sarcopenia: the mediating role of osteoporosis. J Clin Endocrinol Metab 109:e1105\u2013e16","journal-title":"J Clin Endocrinol Metab"},{"key":"5657_CR34","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1080\/08952841.2019.1697161","volume":"33","author":"Y Eguchi","year":"2021","unstructured":"Eguchi Y, Toyoguchi T, Inage K, Fujimoto K, Orita S, Suzuki M et al (2021) Advanced glycation end-products are associated with sarcopenia in older women: aging marker dynamics. J Women Aging 33:328\u2013340","journal-title":"J Women Aging"},{"key":"5657_CR35","doi-asserted-by":"crossref","first-page":"109136","DOI":"10.1016\/j.celrep.2021.109136","volume":"35","author":"J Ostojic","year":"2021","unstructured":"Ostojic J, Yoon YS, Sonntag T, Nguyen B, Vaughan JM, Shokhirev M et al (2021) Transcriptional co-activator regulates melanocyte differentiation and oncogenesis by integrating cAMP and MAPK\/ERK pathways. Cell Rep 35:109136","journal-title":"Cell Rep"},{"key":"5657_CR36","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.3390\/cells11142178","volume":"11","author":"M Takeuchi","year":"2022","unstructured":"Takeuchi M, Sakasai-Sakai A, Takata T, Takino JI, Koriyama Y (2022) Effects of toxic ages (TAGE) on human health. Cells 11:2178","journal-title":"Cells"},{"key":"5657_CR37","doi-asserted-by":"crossref","first-page":"107282","DOI":"10.1016\/j.phrs.2024.107282","volume":"206","author":"M Zhou","year":"2024","unstructured":"Zhou M, Zhang Y, Shi L, Li L, Zhang D, Gong Z et al (2024) Activation and modulation of the AGEs-RAGE axis: implications for inflammatory pathologies and therapeutic interventions\u2013 A review. Pharmacol Res 206:107282","journal-title":"Pharmacol Res"},{"key":"5657_CR38","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/s41580-019-0155-x","volume":"20","author":"E Guccione","year":"2019","unstructured":"Guccione E, Richard S (2019) The regulation, functions and clinical relevance of arginine methylation. Nat Rev Mol Cell Biol 20:642\u2013657","journal-title":"Nat Rev Mol Cell Biol"},{"key":"5657_CR39","doi-asserted-by":"crossref","unstructured":"An D, Kim J, Moon B, Kim H, Nguyen H, Park S et al (2024) PRMT1-mediated methylation regulates MLL2 stability and gene expression. Nucleic Acids Res gkae1227","DOI":"10.1093\/nar\/gkae1227"},{"key":"5657_CR40","doi-asserted-by":"crossref","first-page":"102309","DOI":"10.1016\/j.jbc.2022.102309","volume":"298","author":"Q Zhu","year":"2022","unstructured":"Zhu Q, Wang D, Liang F, Tong X, Liang Z, Wang X et al (2022) Protein arginine methyltransferase PRMT1 promotes adipogenesis by modulating transcription factors C\/EBP\u03b2 and PPAR\u03b3. J Biol Chem 298:102309","journal-title":"J Biol Chem"}],"container-title":["Cellular and Molecular Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-025-05657-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00018-025-05657-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-025-05657-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T12:01:16Z","timestamp":1744027276000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00018-025-05657-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,7]]},"references-count":40,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["5657"],"URL":"https:\/\/doi.org\/10.1007\/s00018-025-05657-1","relation":{},"ISSN":["1420-9071"],"issn-type":[{"value":"1420-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,7]]},"assertion":[{"value":"19 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 March 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 March 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 April 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experiments were performed following a protocol (JPH-21-0012) approved by the Institutional Animal Care and Use Committee at Jiangxi Provincial People\u2019s Hospital.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All authors agree with the publication of this article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"142"}}