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The use of human specimens was approved by the Ethical Committee of Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico (n\u00b0 1982, 14th January 2020) and by the Ethical Committee of IRCCS Ospedale San Raffaele (IPF002-2014, 6th June 2014). Human healthy pancreatic tissues were obtained from the Diabetes Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy from multi-organ donors. The use of human specimens was approved by the Institutional Review Board. Human islets were isolated as previously described [] at the Pancreatic Islet Processing Unit, a National Transplant Center accredited facility (IT000679) [].","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"This study does not contain any individual personal data including any individual\u2019s name, images, or videos.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}],"article-number":"125"}}