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The procedures used in this study adhere to the tenets of the Declaration of Helsinki and informed consent was obtained from all individual participants included in the study. The studies also have been approved by a research ethics committee at the Experimental Animal Center of Central South University (XMSB-2023-0062).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors affirm that human research participants provided informed consent for publication of all the human data.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"180"}}